TY  - JOUR
AU  - Hrnčić, Dragan
AU  - Rašić-Marković, Aleksandra
AU  - Lekovic, J.
AU  - Krstić, Danijela Z.
AU  - Čolović, Mirjana B.
AU  - Macut, D.
AU  - Šušić, Veselinka
AU  - Đurić, Dragan M.
AU  - Stanojlović, Olivera
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6049
AB  - The aim of the study was to examine the effects of chronic exercise training on seizures induced by homocysteine thiolactone (HCT) in adult rats. Rats were assigned to: sedentary control; exercise control; sedentary +HCT; exercise + HCT group. Animals in the exercise groups ran 30 min daily on a treadmill for 30 consecutive days (belt speed 20 m/min), while sedentary rats spent the same time on the treadmill (speed 0 m/min). On the 31st day, the HCT groups received HCT (8.0 mmol/kg), while the control groups received vehicle. Afterwards, convulsive behavior and EEG activity were registered. Lipid peroxidation, superoxide dismutase (SOD) and catalase (CAT) activity were ascertained in the rat hippocampus. No signs of seizures were registered in sedentary and exercise control rats. Seizure latency was increased, while number of seizure episodes and spike-and-wave discharges (SWD) in EEG were decreased in the exercise + HCT compared to the sedentary +HCT group. Seizure incidence, the severity thereof and duration of SWDs were not significantly different between these groups. Exercise partly prevented increase of lipid peroxidation and decrease of the SOD and CAT activity after HCT administration. These results indicate beneficial effects of exercise in model of HCT induced seizures in rats, what could be, at least in part, a consequence of improved antioxidant enzymes activity.
T2  - International Journal of Sports Medicine
T1  - Exercise Decreases Susceptibility to Homocysteine Seizures: the Role of Oxidative Stress
VL  - 35
IS  - 7
SP  - 544
EP  - 550
DO  - 10.1055/s-0033-1357162
ER  - 

@article{
author = "Hrnčić, Dragan and Rašić-Marković, Aleksandra and Lekovic, J. and Krstić, Danijela Z. and Čolović, Mirjana B. and Macut, D. and Šušić, Veselinka and Đurić, Dragan M. and Stanojlović, Olivera",
year = "2014",
abstract = "The aim of the study was to examine the effects of chronic exercise training on seizures induced by homocysteine thiolactone (HCT) in adult rats. Rats were assigned to: sedentary control; exercise control; sedentary +HCT; exercise + HCT group. Animals in the exercise groups ran 30 min daily on a treadmill for 30 consecutive days (belt speed 20 m/min), while sedentary rats spent the same time on the treadmill (speed 0 m/min). On the 31st day, the HCT groups received HCT (8.0 mmol/kg), while the control groups received vehicle. Afterwards, convulsive behavior and EEG activity were registered. Lipid peroxidation, superoxide dismutase (SOD) and catalase (CAT) activity were ascertained in the rat hippocampus. No signs of seizures were registered in sedentary and exercise control rats. Seizure latency was increased, while number of seizure episodes and spike-and-wave discharges (SWD) in EEG were decreased in the exercise + HCT compared to the sedentary +HCT group. Seizure incidence, the severity thereof and duration of SWDs were not significantly different between these groups. Exercise partly prevented increase of lipid peroxidation and decrease of the SOD and CAT activity after HCT administration. These results indicate beneficial effects of exercise in model of HCT induced seizures in rats, what could be, at least in part, a consequence of improved antioxidant enzymes activity.",
journal = "International Journal of Sports Medicine",
title = "Exercise Decreases Susceptibility to Homocysteine Seizures: the Role of Oxidative Stress",
volume = "35",
number = "7",
pages = "544-550",
doi = "10.1055/s-0033-1357162"
}

Hrnčić, D., Rašić-Marković, A., Lekovic, J., Krstić, D. Z., Čolović, M. B., Macut, D., Šušić, V., Đurić, D. M.,& Stanojlović, O.. (2014). Exercise Decreases Susceptibility to Homocysteine Seizures: the Role of Oxidative Stress. in International Journal of Sports Medicine, 35(7), 544-550.
https://doi.org/10.1055/s-0033-1357162

Hrnčić D, Rašić-Marković A, Lekovic J, Krstić DZ, Čolović MB, Macut D, Šušić V, Đurić DM, Stanojlović O. Exercise Decreases Susceptibility to Homocysteine Seizures: the Role of Oxidative Stress. in International Journal of Sports Medicine. 2014;35(7):544-550.
doi:10.1055/s-0033-1357162 .

Hrnčić, Dragan, Rašić-Marković, Aleksandra, Lekovic, J., Krstić, Danijela Z., Čolović, Mirjana B., Macut, D., Šušić, Veselinka, Đurić, Dragan M., Stanojlović, Olivera, "Exercise Decreases Susceptibility to Homocysteine Seizures: the Role of Oxidative Stress" in International Journal of Sports Medicine, 35, no. 7 (2014):544-550,
https://doi.org/10.1055/s-0033-1357162 . .

TY  - JOUR
AU  - Mladenovic, D.
AU  - Hrnčić, Dragan
AU  - Rašić-Marković, Aleksandra
AU  - Puškaš, Nela
AU  - Petrovic, S.
AU  - Stanojlović, Olivera
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5226
AB  - Thioacetamide (TAA) is widely used as a model of hepatic encephalopathy (HE). The aim of our study was to investigate the effects of TAA on electroencephalographic (EEG) changes in rats and to compare them with human HE. Male Wistar rats were divided into groups: (1) saline-treated group and (2) TAA-treated groups: TAA(300) (300 mg/kg), TAA(600) (600 mg/kg), and TAA(900) (900 mg/kg). Daily dose of TAA (300 mg/kg) was administered intraperitoneally once (TAA(300)), twice (TAA(600)), or thrice (TAA(900)) in subsequent days. EEG changes were recorded about 24 h after the last dose of TAA. Absolute and relative power density in alpha bands were significantly higher in TAA(300) versus control group. In TAA(300), absolute beta power density was higher and relative beta power density was lower versus control group. Absolute alpha, theta, delta, and relative theta power were significantly lower, while relative power in delta band was significantly higher in TAA(900) versus control group (p LT 0.01). In conclusion, decrease in EEG voltage with an increase in delta relative power, which correspond to the EEG manifestations of severe HE in humans, was observed in TAA(900) group. Electrical activity in TAA(300) group correlates with mild HE in humans.
T2  - Human and Experimental Toxicology
T1  - Spectral analysis of thioacetamide-induced electroencephalographic changes in rats
VL  - 32
IS  - 1
SP  - 90
EP  - 100
DO  - 10.1177/0960327112456312
ER  - 

@article{
author = "Mladenovic, D. and Hrnčić, Dragan and Rašić-Marković, Aleksandra and Puškaš, Nela and Petrovic, S. and Stanojlović, Olivera",
year = "2013",
abstract = "Thioacetamide (TAA) is widely used as a model of hepatic encephalopathy (HE). The aim of our study was to investigate the effects of TAA on electroencephalographic (EEG) changes in rats and to compare them with human HE. Male Wistar rats were divided into groups: (1) saline-treated group and (2) TAA-treated groups: TAA(300) (300 mg/kg), TAA(600) (600 mg/kg), and TAA(900) (900 mg/kg). Daily dose of TAA (300 mg/kg) was administered intraperitoneally once (TAA(300)), twice (TAA(600)), or thrice (TAA(900)) in subsequent days. EEG changes were recorded about 24 h after the last dose of TAA. Absolute and relative power density in alpha bands were significantly higher in TAA(300) versus control group. In TAA(300), absolute beta power density was higher and relative beta power density was lower versus control group. Absolute alpha, theta, delta, and relative theta power were significantly lower, while relative power in delta band was significantly higher in TAA(900) versus control group (p LT 0.01). In conclusion, decrease in EEG voltage with an increase in delta relative power, which correspond to the EEG manifestations of severe HE in humans, was observed in TAA(900) group. Electrical activity in TAA(300) group correlates with mild HE in humans.",
journal = "Human and Experimental Toxicology",
title = "Spectral analysis of thioacetamide-induced electroencephalographic changes in rats",
volume = "32",
number = "1",
pages = "90-100",
doi = "10.1177/0960327112456312"
}

Mladenovic, D., Hrnčić, D., Rašić-Marković, A., Puškaš, N., Petrovic, S.,& Stanojlović, O.. (2013). Spectral analysis of thioacetamide-induced electroencephalographic changes in rats. in Human and Experimental Toxicology, 32(1), 90-100.
https://doi.org/10.1177/0960327112456312

Mladenovic D, Hrnčić D, Rašić-Marković A, Puškaš N, Petrovic S, Stanojlović O. Spectral analysis of thioacetamide-induced electroencephalographic changes in rats. in Human and Experimental Toxicology. 2013;32(1):90-100.
doi:10.1177/0960327112456312 .

Mladenovic, D., Hrnčić, Dragan, Rašić-Marković, Aleksandra, Puškaš, Nela, Petrovic, S., Stanojlović, Olivera, "Spectral analysis of thioacetamide-induced electroencephalographic changes in rats" in Human and Experimental Toxicology, 32, no. 1 (2013):90-100,
https://doi.org/10.1177/0960327112456312 . .

TY  - JOUR
AU  - Mladenovic, Dusan
AU  - Krstić, Danijela Z.
AU  - Čolović, Mirjana B.
AU  - Radosavljevic, Tatjana
AU  - Rašić-Marković, Aleksandra
AU  - Hrnčić, Dragan
AU  - Macut, Djuro
AU  - Stanojlović, Olivera
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4696
AB  - Thioacetamide (TAA) exerts hepatotoxic, neurotoxic and carcinogenic effects. The aim of our study was to investigate the effects of TAA on lipid peroxidation and catalase activity in various rat brain regions. Male Wistar rats were divided into following groups: 1. control, saline-treated; 2. thioacetamide-treated groups, TAA(300) (300 mg/kg), TAA(600) (600 mg/kg) and TAA(900) (900 mg/kg). Daily dose of TAA (300 mg/kg) was administered intraperitoneally once (TAA(300)), twice (TAA(600)) and three times (TAA(900)) in consecutive days. Brain samples were collected 24 h after the last dose of TAA and malondialdehyde (MDA) level and catalase activity were determined in cortex, brainstem and hippocampus. MDA level was significantly increased while catalase activity was significantly lower in all brain regions in TAA(900) group in comparison with control group. In TAA(600) MDA level was increased in the brainstem and cortex when compared to control (p LT 0.01). The same dose of TAA(600) mg/kg induced a significant decline in catalase activity in the brainstem and cortex and an increase in its activity in the hippocampus when compared to control (p LT 0.01). In TAA(300) an increase in MDA level was evident only in the brainstem. Catalase activity was significantly higher in the cortex and hippocampus in TAA(300) group in comparison with control (p LT 0.01). Based on these results, it may be concluded that various rat brain regions have different sensitivity to TAA-induced lipid peroxidation with hippocampus being less sensitive than cerebral cortex and brainstem.
T2  - Medicinal Chemistry
T1  - Different Sensitivity of Various Brain Structures to Thioacetamide-Induced Lipid Peroxidation
VL  - 8
IS  - 1
SP  - 52
EP  - 58
DO  - 10.2174/157340612799278603
ER  - 

@article{
author = "Mladenovic, Dusan and Krstić, Danijela Z. and Čolović, Mirjana B. and Radosavljevic, Tatjana and Rašić-Marković, Aleksandra and Hrnčić, Dragan and Macut, Djuro and Stanojlović, Olivera",
year = "2012",
abstract = "Thioacetamide (TAA) exerts hepatotoxic, neurotoxic and carcinogenic effects. The aim of our study was to investigate the effects of TAA on lipid peroxidation and catalase activity in various rat brain regions. Male Wistar rats were divided into following groups: 1. control, saline-treated; 2. thioacetamide-treated groups, TAA(300) (300 mg/kg), TAA(600) (600 mg/kg) and TAA(900) (900 mg/kg). Daily dose of TAA (300 mg/kg) was administered intraperitoneally once (TAA(300)), twice (TAA(600)) and three times (TAA(900)) in consecutive days. Brain samples were collected 24 h after the last dose of TAA and malondialdehyde (MDA) level and catalase activity were determined in cortex, brainstem and hippocampus. MDA level was significantly increased while catalase activity was significantly lower in all brain regions in TAA(900) group in comparison with control group. In TAA(600) MDA level was increased in the brainstem and cortex when compared to control (p LT 0.01). The same dose of TAA(600) mg/kg induced a significant decline in catalase activity in the brainstem and cortex and an increase in its activity in the hippocampus when compared to control (p LT 0.01). In TAA(300) an increase in MDA level was evident only in the brainstem. Catalase activity was significantly higher in the cortex and hippocampus in TAA(300) group in comparison with control (p LT 0.01). Based on these results, it may be concluded that various rat brain regions have different sensitivity to TAA-induced lipid peroxidation with hippocampus being less sensitive than cerebral cortex and brainstem.",
journal = "Medicinal Chemistry",
title = "Different Sensitivity of Various Brain Structures to Thioacetamide-Induced Lipid Peroxidation",
volume = "8",
number = "1",
pages = "52-58",
doi = "10.2174/157340612799278603"
}

Mladenovic, D., Krstić, D. Z., Čolović, M. B., Radosavljevic, T., Rašić-Marković, A., Hrnčić, D., Macut, D.,& Stanojlović, O.. (2012). Different Sensitivity of Various Brain Structures to Thioacetamide-Induced Lipid Peroxidation. in Medicinal Chemistry, 8(1), 52-58.
https://doi.org/10.2174/157340612799278603

Mladenovic D, Krstić DZ, Čolović MB, Radosavljevic T, Rašić-Marković A, Hrnčić D, Macut D, Stanojlović O. Different Sensitivity of Various Brain Structures to Thioacetamide-Induced Lipid Peroxidation. in Medicinal Chemistry. 2012;8(1):52-58.
doi:10.2174/157340612799278603 .

Mladenovic, Dusan, Krstić, Danijela Z., Čolović, Mirjana B., Radosavljevic, Tatjana, Rašić-Marković, Aleksandra, Hrnčić, Dragan, Macut, Djuro, Stanojlović, Olivera, "Different Sensitivity of Various Brain Structures to Thioacetamide-Induced Lipid Peroxidation" in Medicinal Chemistry, 8, no. 1 (2012):52-58,
https://doi.org/10.2174/157340612799278603 . .