TY  - JOUR
AU  - Glišić, Sanja
AU  - Senćanski, Milan V.
AU  - Perović, Vladimir R.
AU  - Stevanović, Strahinja
AU  - Garcia-Sosa, Alfonso T.
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1187
AB  - Arginase, a drug target for the treatment of leishmaniasis, is involved in the biosynthesis of polyamines. Flavonoids are interesting natural compounds found in many foods and some of them may inhibit this enzyme. The MetIDB database containing 5667 compounds was screened using an EIIP/AQVN filter and 3D QSAR to find the most promising candidate compounds. In addition, these top hits were screened in silico versus human arginase and an anti-target battery consisting of cytochromes P450 2a6, 2c9, 3a4, sulfotransferase, and the pregnane-X-receptor in order to flag their possible interactions with these proteins involved in the metabolism of substances. The resulting compounds may have promise to be further developed for the treatment of leishmaniasis.
T2  - Molecules
T1  - Arginase Flavonoid Anti-Leishmanial in Silico Inhibitors Flagged against Anti-Targets
VL  - 21
IS  - 5
SP  - 589
DO  - 10.3390/molecules21050589
ER  - 

@article{
author = "Glišić, Sanja and Senćanski, Milan V. and Perović, Vladimir R. and Stevanović, Strahinja and Garcia-Sosa, Alfonso T.",
year = "2016",
abstract = "Arginase, a drug target for the treatment of leishmaniasis, is involved in the biosynthesis of polyamines. Flavonoids are interesting natural compounds found in many foods and some of them may inhibit this enzyme. The MetIDB database containing 5667 compounds was screened using an EIIP/AQVN filter and 3D QSAR to find the most promising candidate compounds. In addition, these top hits were screened in silico versus human arginase and an anti-target battery consisting of cytochromes P450 2a6, 2c9, 3a4, sulfotransferase, and the pregnane-X-receptor in order to flag their possible interactions with these proteins involved in the metabolism of substances. The resulting compounds may have promise to be further developed for the treatment of leishmaniasis.",
journal = "Molecules",
title = "Arginase Flavonoid Anti-Leishmanial in Silico Inhibitors Flagged against Anti-Targets",
volume = "21",
number = "5",
pages = "589",
doi = "10.3390/molecules21050589"
}

Glišić, S., Senćanski, M. V., Perović, V. R., Stevanović, S.,& Garcia-Sosa, A. T.. (2016). Arginase Flavonoid Anti-Leishmanial in Silico Inhibitors Flagged against Anti-Targets. in Molecules, 21(5), 589.
https://doi.org/10.3390/molecules21050589

Glišić S, Senćanski MV, Perović VR, Stevanović S, Garcia-Sosa AT. Arginase Flavonoid Anti-Leishmanial in Silico Inhibitors Flagged against Anti-Targets. in Molecules. 2016;21(5):589.
doi:10.3390/molecules21050589 .

Glišić, Sanja, Senćanski, Milan V., Perović, Vladimir R., Stevanović, Strahinja, Garcia-Sosa, Alfonso T., "Arginase Flavonoid Anti-Leishmanial in Silico Inhibitors Flagged against Anti-Targets" in Molecules, 21, no. 5 (2016):589,
https://doi.org/10.3390/molecules21050589 . .