TY  - JOUR
AU  - Fontbonne, C.
AU  - Ujić, Predrag
AU  - de Oliveira Santos, F.
AU  - Flechard, Xavier
AU  - Rotaru, Florin
AU  - Achouri, Lynda N.
AU  - Girard Alcindor, V.
AU  - Bastin, Beyhan
AU  - Boulay, Francois
AU  - Briand, J. B.
AU  - Sanchez-Benitez, Angel Miguel
AU  - Bouzomita, H.
AU  - Borcea, Catalin
AU  - Borcea, Ruxandra
AU  - Blank, Bertram B.
AU  - Carniol, Benjamin
AU  - Čeliković, Igor T.
AU  - Delahaye, Pierre
AU  - Delaunay, F.
AU  - Etasse, David
AU  - Fremont, Georges
AU  - de France, Gilles
AU  - Fontbonne, Jean Marc
AU  - Grinyer, G. F.
AU  - Harang, J.
AU  - Hommet, Jean
AU  - Jevremović, Aleksandar M.
AU  - Lewitowicz, Marek
AU  - Martel, Ismael
AU  - Mrazek, Jaromir
AU  - Parlog, Marian
AU  - Poincheval, J.
AU  - Ramos, Diego
AU  - Spitaels, C.
AU  - Stanoiu, Mihai
AU  - Thomas, Jean-Charles
AU  - Toprek, Dragan
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1864
AB  - The half-life of Ne-19 was measured using a real-time digital multiparametric acquisition system, providing an accurate time stamp and relevant information on the detector signals for each decay event. An exhaustive offline analysis of the data gave unique access to experimental effects potentially biasing the measurement. After establishing the influence factors impacting the measurement such as after-pulses, pile-up, gain, and baseline fluctuations, their effects were accurately estimated and the event selection optimized. The resulting half-life, 17.2569 +/- 0.0019((stat)) +/- 0.0009((syst)) s, is the most precise up to now for Ne-19. It is found to be in agreement with two recent precise measurements and not consistent with the most recent one [L.J. Broussard et al., Phys. Rev. Lett. 112, 212301 (2014)] by 3.0 standard deviations. The full potential of the technique for nuclei with half-lives of a few seconds is discussed.
T2  - Physical Review C
T1  - High precision measurement of the Ne-19 beta-decay half-life using real-time digital acquisition
VL  - 96
IS  - 6
DO  - 10.1103/PhysRevC.96.065501
ER  - 

@article{
author = "Fontbonne, C. and Ujić, Predrag and de Oliveira Santos, F. and Flechard, Xavier and Rotaru, Florin and Achouri, Lynda N. and Girard Alcindor, V. and Bastin, Beyhan and Boulay, Francois and Briand, J. B. and Sanchez-Benitez, Angel Miguel and Bouzomita, H. and Borcea, Catalin and Borcea, Ruxandra and Blank, Bertram B. and Carniol, Benjamin and Čeliković, Igor T. and Delahaye, Pierre and Delaunay, F. and Etasse, David and Fremont, Georges and de France, Gilles and Fontbonne, Jean Marc and Grinyer, G. F. and Harang, J. and Hommet, Jean and Jevremović, Aleksandar M. and Lewitowicz, Marek and Martel, Ismael and Mrazek, Jaromir and Parlog, Marian and Poincheval, J. and Ramos, Diego and Spitaels, C. and Stanoiu, Mihai and Thomas, Jean-Charles and Toprek, Dragan",
year = "2017",
abstract = "The half-life of Ne-19 was measured using a real-time digital multiparametric acquisition system, providing an accurate time stamp and relevant information on the detector signals for each decay event. An exhaustive offline analysis of the data gave unique access to experimental effects potentially biasing the measurement. After establishing the influence factors impacting the measurement such as after-pulses, pile-up, gain, and baseline fluctuations, their effects were accurately estimated and the event selection optimized. The resulting half-life, 17.2569 +/- 0.0019((stat)) +/- 0.0009((syst)) s, is the most precise up to now for Ne-19. It is found to be in agreement with two recent precise measurements and not consistent with the most recent one [L.J. Broussard et al., Phys. Rev. Lett. 112, 212301 (2014)] by 3.0 standard deviations. The full potential of the technique for nuclei with half-lives of a few seconds is discussed.",
journal = "Physical Review C",
title = "High precision measurement of the Ne-19 beta-decay half-life using real-time digital acquisition",
volume = "96",
number = "6",
doi = "10.1103/PhysRevC.96.065501"
}

Fontbonne, C., Ujić, P., de Oliveira Santos, F., Flechard, X., Rotaru, F., Achouri, L. N., Girard Alcindor, V., Bastin, B., Boulay, F., Briand, J. B., Sanchez-Benitez, A. M., Bouzomita, H., Borcea, C., Borcea, R., Blank, B. B., Carniol, B., Čeliković, I. T., Delahaye, P., Delaunay, F., Etasse, D., Fremont, G., de France, G., Fontbonne, J. M., Grinyer, G. F., Harang, J., Hommet, J., Jevremović, A. M., Lewitowicz, M., Martel, I., Mrazek, J., Parlog, M., Poincheval, J., Ramos, D., Spitaels, C., Stanoiu, M., Thomas, J.,& Toprek, D.. (2017). High precision measurement of the Ne-19 beta-decay half-life using real-time digital acquisition. in Physical Review C, 96(6).
https://doi.org/10.1103/PhysRevC.96.065501

Fontbonne C, Ujić P, de Oliveira Santos F, Flechard X, Rotaru F, Achouri LN, Girard Alcindor V, Bastin B, Boulay F, Briand JB, Sanchez-Benitez AM, Bouzomita H, Borcea C, Borcea R, Blank BB, Carniol B, Čeliković IT, Delahaye P, Delaunay F, Etasse D, Fremont G, de France G, Fontbonne JM, Grinyer GF, Harang J, Hommet J, Jevremović AM, Lewitowicz M, Martel I, Mrazek J, Parlog M, Poincheval J, Ramos D, Spitaels C, Stanoiu M, Thomas J, Toprek D. High precision measurement of the Ne-19 beta-decay half-life using real-time digital acquisition. in Physical Review C. 2017;96(6).
doi:10.1103/PhysRevC.96.065501 .

Fontbonne, C., Ujić, Predrag, de Oliveira Santos, F., Flechard, Xavier, Rotaru, Florin, Achouri, Lynda N., Girard Alcindor, V., Bastin, Beyhan, Boulay, Francois, Briand, J. B., Sanchez-Benitez, Angel Miguel, Bouzomita, H., Borcea, Catalin, Borcea, Ruxandra, Blank, Bertram B., Carniol, Benjamin, Čeliković, Igor T., Delahaye, Pierre, Delaunay, F., Etasse, David, Fremont, Georges, de France, Gilles, Fontbonne, Jean Marc, Grinyer, G. F., Harang, J., Hommet, Jean, Jevremović, Aleksandar M., Lewitowicz, Marek, Martel, Ismael, Mrazek, Jaromir, Parlog, Marian, Poincheval, J., Ramos, Diego, Spitaels, C., Stanoiu, Mihai, Thomas, Jean-Charles, Toprek, Dragan, "High precision measurement of the Ne-19 beta-decay half-life using real-time digital acquisition" in Physical Review C, 96, no. 6 (2017),
https://doi.org/10.1103/PhysRevC.96.065501 . .

TY  - JOUR
AU  - Keta, Otilija D.
AU  - Todorović, Danijela V.
AU  - Bulat, Tanja M.
AU  - Cirrone, Giuseppe Antonio Pablo
AU  - Romano, Francesco
AU  - Cuttone, Giacomo
AU  - Petrović, Ivan M.
AU  - Ristić-Fira, Aleksandra
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1573
AB  - The aim of this study was to investigate effects of irradiations with the therapeutic proton and carbon ion beams in two non-small cell lung cancers, CRL5876 adenocarcinoma and HTB177 large cell lung carcinoma. The DNA damage response dynamics, cell cycle regulation, and cell death pathway activation were followed. Viability of both cell lines was lower after carbon ions compared to the therapeutic proton irradiations. HTB177 cells showed higher recovery than CRL5876 cells seven days following the treatments, but the survival rates of both cell lines were lower after exposure to carbon ions with respect to therapeutic protons. When analyzing cell cycle distribution of both CRL5876 and HTB177 cells, it was noticed that therapeutic protons predominantly induced G1 arrest, while the cells after carbon ions were arrested in G2/M phase. The results illustrated that differences in the levels of phosphorylated H2AX, a double-strand break marker, exist after therapeutic proton and carbon ion irradiations. We also observed dose- and time-dependent increase in the p53 and p21 levels after applied irradiations. Carbon ions caused larger increase in the quantity of p53 and p21 compared to therapeutic protons. These results suggested that various repair mechanisms were induced in the treated cells. Considering the fact that we have not observed any distinct change in the Bax/Bcl-2 ratio following irradiations, it seemed that different types of cell death were involved in the response to the two types of irradiations that were applied.
T2  - Experimental Biology and Medicine
T1  - Comparison of human lung cancer cell radiosensitivity after irradiations with therapeutic protons and carbon ions
VL  - 242
IS  - 10
SP  - 1015
EP  - 1024
DO  - 10.1177/1535370216669611
ER  - 

@article{
author = "Keta, Otilija D. and Todorović, Danijela V. and Bulat, Tanja M. and Cirrone, Giuseppe Antonio Pablo and Romano, Francesco and Cuttone, Giacomo and Petrović, Ivan M. and Ristić-Fira, Aleksandra",
year = "2017",
abstract = "The aim of this study was to investigate effects of irradiations with the therapeutic proton and carbon ion beams in two non-small cell lung cancers, CRL5876 adenocarcinoma and HTB177 large cell lung carcinoma. The DNA damage response dynamics, cell cycle regulation, and cell death pathway activation were followed. Viability of both cell lines was lower after carbon ions compared to the therapeutic proton irradiations. HTB177 cells showed higher recovery than CRL5876 cells seven days following the treatments, but the survival rates of both cell lines were lower after exposure to carbon ions with respect to therapeutic protons. When analyzing cell cycle distribution of both CRL5876 and HTB177 cells, it was noticed that therapeutic protons predominantly induced G1 arrest, while the cells after carbon ions were arrested in G2/M phase. The results illustrated that differences in the levels of phosphorylated H2AX, a double-strand break marker, exist after therapeutic proton and carbon ion irradiations. We also observed dose- and time-dependent increase in the p53 and p21 levels after applied irradiations. Carbon ions caused larger increase in the quantity of p53 and p21 compared to therapeutic protons. These results suggested that various repair mechanisms were induced in the treated cells. Considering the fact that we have not observed any distinct change in the Bax/Bcl-2 ratio following irradiations, it seemed that different types of cell death were involved in the response to the two types of irradiations that were applied.",
journal = "Experimental Biology and Medicine",
title = "Comparison of human lung cancer cell radiosensitivity after irradiations with therapeutic protons and carbon ions",
volume = "242",
number = "10",
pages = "1015-1024",
doi = "10.1177/1535370216669611"
}

Keta, O. D., Todorović, D. V., Bulat, T. M., Cirrone, G. A. P., Romano, F., Cuttone, G., Petrović, I. M.,& Ristić-Fira, A.. (2017). Comparison of human lung cancer cell radiosensitivity after irradiations with therapeutic protons and carbon ions. in Experimental Biology and Medicine, 242(10), 1015-1024.
https://doi.org/10.1177/1535370216669611

Keta OD, Todorović DV, Bulat TM, Cirrone GAP, Romano F, Cuttone G, Petrović IM, Ristić-Fira A. Comparison of human lung cancer cell radiosensitivity after irradiations with therapeutic protons and carbon ions. in Experimental Biology and Medicine. 2017;242(10):1015-1024.
doi:10.1177/1535370216669611 .

Keta, Otilija D., Todorović, Danijela V., Bulat, Tanja M., Cirrone, Giuseppe Antonio Pablo, Romano, Francesco, Cuttone, Giacomo, Petrović, Ivan M., Ristić-Fira, Aleksandra, "Comparison of human lung cancer cell radiosensitivity after irradiations with therapeutic protons and carbon ions" in Experimental Biology and Medicine, 242, no. 10 (2017):1015-1024,
https://doi.org/10.1177/1535370216669611 . .

TY  - JOUR
AU  - Hagen, T. W.
AU  - Görgen, Andreas
AU  - Korten, Wolfram
AU  - Grente, Lucie
AU  - Salsac, Marie Delphine
AU  - Farget, Fanny
AU  - Ragnarsson, Ingemar
AU  - Braunroth, Thomas
AU  - Bruyneel, Bart
AU  - Čeliković, Igor T.
AU  - Clement, Emmanuel
AU  - de France, Gilles
AU  - Delaune, Olivier
AU  - Dewald, Alfred
AU  - Dijon, A.
AU  - Hackstein, Matthias
AU  - Jacquot, Bertrand
AU  - Litzinger, J.
AU  - Ljungvall, Joa
AU  - Louchart, C.
AU  - Michelagnoli, Caterina
AU  - Napoli, Daniel R.
AU  - Recchia, Francesco
AU  - Rother, Wolfram
AU  - Sahin, Eda
AU  - Siem, Sunniva
AU  - Sulignano, Barbara
AU  - Theisen, Christophe
AU  - Valiente-Dobon, Jose Javier
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1452
AB  - Lifetimes of excited states in Y-99, Y-101, Nb-101, Nb-103, and Nb-105 were measured in an experiment using the recoil distance Doppler shift method at GANIL (Grand Accelerateur National dIons Lourds). The neutron-rich nuclei were produced in fission reactions between a U-238 beam and a Be-9 target. Prompt gamma rays were measured with the EXOGAM array and correlated with fission fragments that were identified in mass and atomic number with the VAMOS++ spectrometer. The measured lifetimes, together with branching ratios, provide B(M1) and B(E2) values for the strongly coupled rotational bands built on the [422] 5/2(+) ground state in the Y and Nb nuclei with neutron number N GT = 60. The comparison of the experimental results with triaxial particle-rotor calculations provides information about the evolution of the nuclear shape in this mass region.
T2  - Physical Review C
T1  - Evolution of nuclear shapes in odd-mass yttrium and niobium isotopes from lifetime measurements following fission reactions
VL  - 95
IS  - 3
DO  - 10.1103/PhysRevC.95.034302
ER  - 

@article{
author = "Hagen, T. W. and Görgen, Andreas and Korten, Wolfram and Grente, Lucie and Salsac, Marie Delphine and Farget, Fanny and Ragnarsson, Ingemar and Braunroth, Thomas and Bruyneel, Bart and Čeliković, Igor T. and Clement, Emmanuel and de France, Gilles and Delaune, Olivier and Dewald, Alfred and Dijon, A. and Hackstein, Matthias and Jacquot, Bertrand and Litzinger, J. and Ljungvall, Joa and Louchart, C. and Michelagnoli, Caterina and Napoli, Daniel R. and Recchia, Francesco and Rother, Wolfram and Sahin, Eda and Siem, Sunniva and Sulignano, Barbara and Theisen, Christophe and Valiente-Dobon, Jose Javier",
year = "2017",
abstract = "Lifetimes of excited states in Y-99, Y-101, Nb-101, Nb-103, and Nb-105 were measured in an experiment using the recoil distance Doppler shift method at GANIL (Grand Accelerateur National dIons Lourds). The neutron-rich nuclei were produced in fission reactions between a U-238 beam and a Be-9 target. Prompt gamma rays were measured with the EXOGAM array and correlated with fission fragments that were identified in mass and atomic number with the VAMOS++ spectrometer. The measured lifetimes, together with branching ratios, provide B(M1) and B(E2) values for the strongly coupled rotational bands built on the [422] 5/2(+) ground state in the Y and Nb nuclei with neutron number N GT = 60. The comparison of the experimental results with triaxial particle-rotor calculations provides information about the evolution of the nuclear shape in this mass region.",
journal = "Physical Review C",
title = "Evolution of nuclear shapes in odd-mass yttrium and niobium isotopes from lifetime measurements following fission reactions",
volume = "95",
number = "3",
doi = "10.1103/PhysRevC.95.034302"
}

Hagen, T. W., Görgen, A., Korten, W., Grente, L., Salsac, M. D., Farget, F., Ragnarsson, I., Braunroth, T., Bruyneel, B., Čeliković, I. T., Clement, E., de France, G., Delaune, O., Dewald, A., Dijon, A., Hackstein, M., Jacquot, B., Litzinger, J., Ljungvall, J., Louchart, C., Michelagnoli, C., Napoli, D. R., Recchia, F., Rother, W., Sahin, E., Siem, S., Sulignano, B., Theisen, C.,& Valiente-Dobon, J. J.. (2017). Evolution of nuclear shapes in odd-mass yttrium and niobium isotopes from lifetime measurements following fission reactions. in Physical Review C, 95(3).
https://doi.org/10.1103/PhysRevC.95.034302

Hagen TW, Görgen A, Korten W, Grente L, Salsac MD, Farget F, Ragnarsson I, Braunroth T, Bruyneel B, Čeliković IT, Clement E, de France G, Delaune O, Dewald A, Dijon A, Hackstein M, Jacquot B, Litzinger J, Ljungvall J, Louchart C, Michelagnoli C, Napoli DR, Recchia F, Rother W, Sahin E, Siem S, Sulignano B, Theisen C, Valiente-Dobon JJ. Evolution of nuclear shapes in odd-mass yttrium and niobium isotopes from lifetime measurements following fission reactions. in Physical Review C. 2017;95(3).
doi:10.1103/PhysRevC.95.034302 .

Hagen, T. W., Görgen, Andreas, Korten, Wolfram, Grente, Lucie, Salsac, Marie Delphine, Farget, Fanny, Ragnarsson, Ingemar, Braunroth, Thomas, Bruyneel, Bart, Čeliković, Igor T., Clement, Emmanuel, de France, Gilles, Delaune, Olivier, Dewald, Alfred, Dijon, A., Hackstein, Matthias, Jacquot, Bertrand, Litzinger, J., Ljungvall, Joa, Louchart, C., Michelagnoli, Caterina, Napoli, Daniel R., Recchia, Francesco, Rother, Wolfram, Sahin, Eda, Siem, Sunniva, Sulignano, Barbara, Theisen, Christophe, Valiente-Dobon, Jose Javier, "Evolution of nuclear shapes in odd-mass yttrium and niobium isotopes from lifetime measurements following fission reactions" in Physical Review C, 95, no. 3 (2017),
https://doi.org/10.1103/PhysRevC.95.034302 . .

TY  - JOUR
AU  - Žakula, Jelena
AU  - Korićanac, Lela
AU  - Keta, Otilija D.
AU  - Todorović, Danijela V.
AU  - Cirrone, Giuseppe Antonio Pablo
AU  - Romano, Francesco
AU  - Cuttone, Giacomo
AU  - Petrović, Ivan M.
AU  - Ristić-Fira, Aleksandra
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1290
AB  - Background and objectives: The main goal when treating malignancies with radiation is to deprive tumour cells of their reproductive potential. One approach is to induce tumour cell apoptosis. This study was conducted to evaluate the ability of carbon ions (C-12) to induce apoptosis and cell cycle arrest in human HTB140 melanoma cells. Methods: In this in vitro study, human melanoma HTB140 cells were irradiated with the 62 MeV/n carbon (C-12) ion beam, having two different linear energy transfer (LET) values: 197 and 382 keV/mu m. The dose range was 2 to 16 Gy. Cell viability was estimated by the sulforhodamine B assay seven days after irradiation. The cell cycle and apoptosis were evaluated 48 h after irradiation using flow cytometry. At the same time point, protein and gene expression of apoptotic regulators were estimated using the Western blot and q-PCR methods, respectively. Results: Cell viability experiments indicated strong anti-tumour effects of C-12 ions. The analysis of cell cycle showed that C-12 ions blocked HTB140 cells in G2 phase and induced the dose dependent increase of apoptosis. The maximum value of 21.8 per cent was attained after irradiation with LET of 197 keV/mu m at the dose level of 16 Gy. Pro-apoptotic effects of C-12 ions were confirmed by changes of key apoptotic molecules: the p53, Bax, Bcl-2, poly ADP ribose polymerase (PARP) as well as nuclear factor kappa B (NF kappa B). At the level of protein expression, the results indicated significant increases of p53, NF kappa B and Bax/Bcl-2 ratio and PARP cleavage. The Bax/Bcl-2 mRNA ratio was also increased, while no change was detected in the level of NF kappa B mRNA. Interpretation and conclusions: The present results indicated that anti-tumour effects of C-12 ions in human melanoma HTB140 cells were accomplished through induction of the mitochondrial apoptotic pathway as well as G2 arrest.
T2  - Indian Journal of Medical Research
T1  - Carbon ions of different linear energy transfer (LET) values induce apoptosis and G2 cell cycle arrest in radio-resistant melanoma cells
VL  - 143
SP  - 120
EP  - 128
DO  - 10.4103/0971-5916.191811
ER  - 

@article{
author = "Žakula, Jelena and Korićanac, Lela and Keta, Otilija D. and Todorović, Danijela V. and Cirrone, Giuseppe Antonio Pablo and Romano, Francesco and Cuttone, Giacomo and Petrović, Ivan M. and Ristić-Fira, Aleksandra",
year = "2016",
abstract = "Background and objectives: The main goal when treating malignancies with radiation is to deprive tumour cells of their reproductive potential. One approach is to induce tumour cell apoptosis. This study was conducted to evaluate the ability of carbon ions (C-12) to induce apoptosis and cell cycle arrest in human HTB140 melanoma cells. Methods: In this in vitro study, human melanoma HTB140 cells were irradiated with the 62 MeV/n carbon (C-12) ion beam, having two different linear energy transfer (LET) values: 197 and 382 keV/mu m. The dose range was 2 to 16 Gy. Cell viability was estimated by the sulforhodamine B assay seven days after irradiation. The cell cycle and apoptosis were evaluated 48 h after irradiation using flow cytometry. At the same time point, protein and gene expression of apoptotic regulators were estimated using the Western blot and q-PCR methods, respectively. Results: Cell viability experiments indicated strong anti-tumour effects of C-12 ions. The analysis of cell cycle showed that C-12 ions blocked HTB140 cells in G2 phase and induced the dose dependent increase of apoptosis. The maximum value of 21.8 per cent was attained after irradiation with LET of 197 keV/mu m at the dose level of 16 Gy. Pro-apoptotic effects of C-12 ions were confirmed by changes of key apoptotic molecules: the p53, Bax, Bcl-2, poly ADP ribose polymerase (PARP) as well as nuclear factor kappa B (NF kappa B). At the level of protein expression, the results indicated significant increases of p53, NF kappa B and Bax/Bcl-2 ratio and PARP cleavage. The Bax/Bcl-2 mRNA ratio was also increased, while no change was detected in the level of NF kappa B mRNA. Interpretation and conclusions: The present results indicated that anti-tumour effects of C-12 ions in human melanoma HTB140 cells were accomplished through induction of the mitochondrial apoptotic pathway as well as G2 arrest.",
journal = "Indian Journal of Medical Research",
title = "Carbon ions of different linear energy transfer (LET) values induce apoptosis and G2 cell cycle arrest in radio-resistant melanoma cells",
volume = "143",
pages = "120-128",
doi = "10.4103/0971-5916.191811"
}

Žakula, J., Korićanac, L., Keta, O. D., Todorović, D. V., Cirrone, G. A. P., Romano, F., Cuttone, G., Petrović, I. M.,& Ristić-Fira, A.. (2016). Carbon ions of different linear energy transfer (LET) values induce apoptosis and G2 cell cycle arrest in radio-resistant melanoma cells. in Indian Journal of Medical Research, 143, 120-128.
https://doi.org/10.4103/0971-5916.191811

Žakula J, Korićanac L, Keta OD, Todorović DV, Cirrone GAP, Romano F, Cuttone G, Petrović IM, Ristić-Fira A. Carbon ions of different linear energy transfer (LET) values induce apoptosis and G2 cell cycle arrest in radio-resistant melanoma cells. in Indian Journal of Medical Research. 2016;143:120-128.
doi:10.4103/0971-5916.191811 .

Žakula, Jelena, Korićanac, Lela, Keta, Otilija D., Todorović, Danijela V., Cirrone, Giuseppe Antonio Pablo, Romano, Francesco, Cuttone, Giacomo, Petrović, Ivan M., Ristić-Fira, Aleksandra, "Carbon ions of different linear energy transfer (LET) values induce apoptosis and G2 cell cycle arrest in radio-resistant melanoma cells" in Indian Journal of Medical Research, 143 (2016):120-128,
https://doi.org/10.4103/0971-5916.191811 . .