TY  - JOUR
AU  - Todorović, Ana
AU  - Bobić, Katarina
AU  - Veljković, Filip
AU  - Pejić, Snežana
AU  - Glumac, Sofija
AU  - Stanković, Sanja
AU  - Milovanović, Tijana
AU  - Vukoje, Ivana
AU  - Nedeljković, Jovan
AU  - Radojević Škodrić, Sanja
AU  - Pajović, Snežana B.
AU  - Drakulić, Dunja
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13090
AB  - Nanoparticles (NPs), a distinct class of particles ranging in size from 1 to 100 nm, are one of the most promising technologies of the 21st century, and titanium dioxide NPs (TiO2 NPs) are among the most widely produced and used NPs globally. The increased application of TiO2 NPs raises concerns regarding their global safety and risks of exposure. Many animal studies have reported the accumulation of TiO2 NPs in female reproductive organs; however, evidence of the resultant toxicity remains ambiguous. Since the surface area and chemical modifications of NPs can significantly change their cytotoxicity, we aimed to compare the toxic effects of pristine TiO2 powder with surface-modified TiO2 powders with salicylic acid (TiO2/SA) and 5-aminosalicylic acid (TiO2/5-ASA) on the ovaries, oviducts, and uterus on the 14th day following acute oral treatment. The results, based on alterations in food and water intake, body mass, organ-to-body mass ratio, hormonal status, histological features of tissues of interest, and antioxidant parameters, suggest that the modification with 5-ASA can mitigate some of the observed toxic effects of TiO2 powder and encourage future investigations to create NPs that can potentially reduce the harmful effects of TiO2 NPs while preserving their positive impacts.
T2  - Antioxidants
T1  - Comparable Toxicity of Surface-Modified TiO2 Nanoparticles: An In Vivo Experimental Study on Reproductive Toxicity in Rats
VL  - 13
IS  - 2
SP  - 231
DO  - 10.3390/antiox13020231
ER  - 

@article{
author = "Todorović, Ana and Bobić, Katarina and Veljković, Filip and Pejić, Snežana and Glumac, Sofija and Stanković, Sanja and Milovanović, Tijana and Vukoje, Ivana and Nedeljković, Jovan and Radojević Škodrić, Sanja and Pajović, Snežana B. and Drakulić, Dunja",
year = "2024",
abstract = "Nanoparticles (NPs), a distinct class of particles ranging in size from 1 to 100 nm, are one of the most promising technologies of the 21st century, and titanium dioxide NPs (TiO2 NPs) are among the most widely produced and used NPs globally. The increased application of TiO2 NPs raises concerns regarding their global safety and risks of exposure. Many animal studies have reported the accumulation of TiO2 NPs in female reproductive organs; however, evidence of the resultant toxicity remains ambiguous. Since the surface area and chemical modifications of NPs can significantly change their cytotoxicity, we aimed to compare the toxic effects of pristine TiO2 powder with surface-modified TiO2 powders with salicylic acid (TiO2/SA) and 5-aminosalicylic acid (TiO2/5-ASA) on the ovaries, oviducts, and uterus on the 14th day following acute oral treatment. The results, based on alterations in food and water intake, body mass, organ-to-body mass ratio, hormonal status, histological features of tissues of interest, and antioxidant parameters, suggest that the modification with 5-ASA can mitigate some of the observed toxic effects of TiO2 powder and encourage future investigations to create NPs that can potentially reduce the harmful effects of TiO2 NPs while preserving their positive impacts.",
journal = "Antioxidants",
title = "Comparable Toxicity of Surface-Modified TiO2 Nanoparticles: An In Vivo Experimental Study on Reproductive Toxicity in Rats",
volume = "13",
number = "2",
pages = "231",
doi = "10.3390/antiox13020231"
}

Todorović, A., Bobić, K., Veljković, F., Pejić, S., Glumac, S., Stanković, S., Milovanović, T., Vukoje, I., Nedeljković, J., Radojević Škodrić, S., Pajović, S. B.,& Drakulić, D.. (2024). Comparable Toxicity of Surface-Modified TiO2 Nanoparticles: An In Vivo Experimental Study on Reproductive Toxicity in Rats. in Antioxidants, 13(2), 231.
https://doi.org/10.3390/antiox13020231

Todorović A, Bobić K, Veljković F, Pejić S, Glumac S, Stanković S, Milovanović T, Vukoje I, Nedeljković J, Radojević Škodrić S, Pajović SB, Drakulić D. Comparable Toxicity of Surface-Modified TiO2 Nanoparticles: An In Vivo Experimental Study on Reproductive Toxicity in Rats. in Antioxidants. 2024;13(2):231.
doi:10.3390/antiox13020231 .

Todorović, Ana, Bobić, Katarina, Veljković, Filip, Pejić, Snežana, Glumac, Sofija, Stanković, Sanja, Milovanović, Tijana, Vukoje, Ivana, Nedeljković, Jovan, Radojević Škodrić, Sanja, Pajović, Snežana B., Drakulić, Dunja, "Comparable Toxicity of Surface-Modified TiO2 Nanoparticles: An In Vivo Experimental Study on Reproductive Toxicity in Rats" in Antioxidants, 13, no. 2 (2024):231,
https://doi.org/10.3390/antiox13020231 . .