@article{
author = "Popović, Milan and Paskas, Svetlana and Živković, Maja and Đurić-Delić, Tamara and Stanković, Aleksandra and Burysek, L.",
year = "2009",
abstract = "We studied the effect of HCMV (AD-169) on the regulation of PAR1 reporter activity in HUVEC. In HUVEC, HCMV significantly induced activation of PAR1 reporter constructs carrying AP-2-like and two complexes of AP-2/Sp1-binding elements. Shorter constructs with no AP-2-like binding elements had lower activity upon virus inoculation. Moreover, activity of the shortest construct without binding elements was not significantly increased in virus-exposed cells. Furthermore, in HCMV-exposed cells, activity of the PARI reporter was significantly augmented upon p52/RelB transfection. Taken together, the data indicate that activity of the PAR1 promoter is highly dependent on AP-2/Sp1 binding elements and mediated by p52/RelB regulatory factors.",
journal = "Archives of Biological Sciences",
title = "In Hcmv-Exposed Huvec, P52/Relb Regulatory Factors Mediate Activation of the Human Par1 Gene Promoter",
volume = "61",
number = "4",
pages = "613-618",
doi = "10.2298/ABS0904613P"
}