Genetska epidemiologija i farmakogenomika vaskularnih oboljenja

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Genetska epidemiologija i farmakogenomika vaskularnih oboljenja (en)
Генетска eпидемиологија и фармакогеномика васкуларних обољења (sr)
Genetska epidemiologija i farmakogenomika vaskularnih oboljenja (sr_RS)
Authors

Publications

Plasma Levels of Matrix Metalloproteinase-8 in Patients With Carotid Atherosclerosis

Đurić, Tamara; Živković, Maja; Stanković, Aleksandra; Kolaković, Ana; Jekić, Đole; Selaković, Vesna; Alavantić, Dragan

(2010)

TY  - JOUR
AU  - Đurić, Tamara
AU  - Živković, Maja
AU  - Stanković, Aleksandra
AU  - Kolaković, Ana
AU  - Jekić, Đole
AU  - Selaković, Vesna
AU  - Alavantić, Dragan
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4129
AB  - Matrix metalloproteinases (MMPs) are involved in the remodeling of the extracellular matrix (ECM) in the arterial wall during atherogenesis. Collagens are the most abundant proteins in the ECM. MMP-8 is expressed by cells associated with the development of the atherosclerotic plaque. It cleaves collagen type I three times more potently than two other interstitial collagenases MMP-1 and MMP-13. The aim of this study was to investigate whether plasma MMP-8 values are associated with occurrence of carotid plaque (CP) and possible correlations with clinical and biochemical parameters in carotid atherosclerosis (CA) patients. Total plasma MMP-8 levels were quantified by ELISA in 63 patients with ultrasonographic evidence of CP presence and 12 controls. Plasma MMP-8 values were significantly higher in patients with CA compared with controls (median 23.36 ng/ml vs. 13.02 ng/ml, P LT 0.001) but they did not differ significantly according to gender, smoking and hypertensive status, associated diseases, and use of statins. Statistically significant positive correlations were observed between MMP-8 plasma values and C reactive protein (r=0.41, P=0.001), urea (r=0.50, P LT 0.001), aspartate transaminase (r=0.48, P=0.001), and creatinine levels (r=0.38, P=0.006). These results suggest association of MMP-8 plasma levels with occurrence of CP and correlation with certain biochemical markers. J. Clin. Lab. Anal. 24:246-251, 2010. (C) 2010 Wiley-Liss, Inc.
T2  - Journal of Clinical Laboratory Analysis
T1  - Plasma Levels of Matrix Metalloproteinase-8 in Patients With Carotid Atherosclerosis
VL  - 24
IS  - 4
SP  - 246
EP  - 251
DO  - 10.1002/jcla.20393
ER  - 
@article{
author = "Đurić, Tamara and Živković, Maja and Stanković, Aleksandra and Kolaković, Ana and Jekić, Đole and Selaković, Vesna and Alavantić, Dragan",
year = "2010",
abstract = "Matrix metalloproteinases (MMPs) are involved in the remodeling of the extracellular matrix (ECM) in the arterial wall during atherogenesis. Collagens are the most abundant proteins in the ECM. MMP-8 is expressed by cells associated with the development of the atherosclerotic plaque. It cleaves collagen type I three times more potently than two other interstitial collagenases MMP-1 and MMP-13. The aim of this study was to investigate whether plasma MMP-8 values are associated with occurrence of carotid plaque (CP) and possible correlations with clinical and biochemical parameters in carotid atherosclerosis (CA) patients. Total plasma MMP-8 levels were quantified by ELISA in 63 patients with ultrasonographic evidence of CP presence and 12 controls. Plasma MMP-8 values were significantly higher in patients with CA compared with controls (median 23.36 ng/ml vs. 13.02 ng/ml, P LT 0.001) but they did not differ significantly according to gender, smoking and hypertensive status, associated diseases, and use of statins. Statistically significant positive correlations were observed between MMP-8 plasma values and C reactive protein (r=0.41, P=0.001), urea (r=0.50, P LT 0.001), aspartate transaminase (r=0.48, P=0.001), and creatinine levels (r=0.38, P=0.006). These results suggest association of MMP-8 plasma levels with occurrence of CP and correlation with certain biochemical markers. J. Clin. Lab. Anal. 24:246-251, 2010. (C) 2010 Wiley-Liss, Inc.",
journal = "Journal of Clinical Laboratory Analysis",
title = "Plasma Levels of Matrix Metalloproteinase-8 in Patients With Carotid Atherosclerosis",
volume = "24",
number = "4",
pages = "246-251",
doi = "10.1002/jcla.20393"
}
Đurić, T., Živković, M., Stanković, A., Kolaković, A., Jekić, Đ., Selaković, V.,& Alavantić, D.. (2010). Plasma Levels of Matrix Metalloproteinase-8 in Patients With Carotid Atherosclerosis. in Journal of Clinical Laboratory Analysis, 24(4), 246-251.
https://doi.org/10.1002/jcla.20393
Đurić T, Živković M, Stanković A, Kolaković A, Jekić Đ, Selaković V, Alavantić D. Plasma Levels of Matrix Metalloproteinase-8 in Patients With Carotid Atherosclerosis. in Journal of Clinical Laboratory Analysis. 2010;24(4):246-251.
doi:10.1002/jcla.20393 .
Đurić, Tamara, Živković, Maja, Stanković, Aleksandra, Kolaković, Ana, Jekić, Đole, Selaković, Vesna, Alavantić, Dragan, "Plasma Levels of Matrix Metalloproteinase-8 in Patients With Carotid Atherosclerosis" in Journal of Clinical Laboratory Analysis, 24, no. 4 (2010):246-251,
https://doi.org/10.1002/jcla.20393 . .
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Uloga receptora aktiviranih proliferatorom peroksizoma u mehanizmu insulinske osetljivosti

Soskić, Sanja S.; Stanković, Aleksandra; Isenović, Esma R.; Alavantić, Dragan

(2010)

TY  - JOUR
AU  - Soskić, Sanja S.
AU  - Stanković, Aleksandra
AU  - Isenović, Esma R.
AU  - Alavantić, Dragan
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10329
AB  - Diabetes mellitus tipa 2 je hronično, progresivno, poligeno oboljenje koje karakteriše povećan nivo glukoze u cirkulaciji kao i drugi biohemijski poremećaji u organizmu. Nedavno otkriveni receptori aktivirani proliferatorom peroksizoma su transkripcioni faktori koji pripadaju superfamiliji nukleusnih receptora. Dva člana ove familije su receptori aktivirani proliferatorom peroksizoma alfa i gama koji predstavljaju nove gene kandidate za nastanak dijabetesa tipa 2 i metaboličkog sindroma (okarakterisanog kao predijabetesno stanje). Od velikog je značaja fiziološka uloga receptora aktiviranih proliferatorom peroksizoma gama kako u metabolizmu lipida i glukoze tako i u mehanizmu insulinske osetljivosti kome treba dati jedno od centralnih mesta u terapiji dijabetesa tipa 2.
AB  - Type 2 diabetes mellitus is a chronic, progressive, polygenic disease which is characterised by increased glucose levels in circulation and also by many other biochemical disturbances in diabetic patients. Recently discovered, peroxisomal proliferator-activated receptors are transcription factors and members of superfamily of nuclear receptors. Two members of this family peroxisomal proliferator-activated receptors alpha and gamma are novel candidate genes for the onset of type 2 diabetes and metabolic syndrome which is characterised as prediabetic condition. It is of great importance to understand physiological role of peroxisomal proliferator-activated receptors gamma as in lipid and glucose metabolism as in a mechanism of insulin sensitivity which is to be given one of the major role in therapy of type 2 diabetes.
T2  - Materia medica
T1  - Uloga receptora aktiviranih proliferatorom peroksizoma u mehanizmu insulinske osetljivosti
T1  - Role of peroxisomal proliferators: Activated receptors in mechanism of insulin sensitivity
VL  - 26
IS  - 1
SP  - 25
EP  - 31
UR  - https://hdl.handle.net/21.15107/rcub_vinar_10329
ER  - 
@article{
author = "Soskić, Sanja S. and Stanković, Aleksandra and Isenović, Esma R. and Alavantić, Dragan",
year = "2010",
abstract = "Diabetes mellitus tipa 2 je hronično, progresivno, poligeno oboljenje koje karakteriše povećan nivo glukoze u cirkulaciji kao i drugi biohemijski poremećaji u organizmu. Nedavno otkriveni receptori aktivirani proliferatorom peroksizoma su transkripcioni faktori koji pripadaju superfamiliji nukleusnih receptora. Dva člana ove familije su receptori aktivirani proliferatorom peroksizoma alfa i gama koji predstavljaju nove gene kandidate za nastanak dijabetesa tipa 2 i metaboličkog sindroma (okarakterisanog kao predijabetesno stanje). Od velikog je značaja fiziološka uloga receptora aktiviranih proliferatorom peroksizoma gama kako u metabolizmu lipida i glukoze tako i u mehanizmu insulinske osetljivosti kome treba dati jedno od centralnih mesta u terapiji dijabetesa tipa 2., Type 2 diabetes mellitus is a chronic, progressive, polygenic disease which is characterised by increased glucose levels in circulation and also by many other biochemical disturbances in diabetic patients. Recently discovered, peroxisomal proliferator-activated receptors are transcription factors and members of superfamily of nuclear receptors. Two members of this family peroxisomal proliferator-activated receptors alpha and gamma are novel candidate genes for the onset of type 2 diabetes and metabolic syndrome which is characterised as prediabetic condition. It is of great importance to understand physiological role of peroxisomal proliferator-activated receptors gamma as in lipid and glucose metabolism as in a mechanism of insulin sensitivity which is to be given one of the major role in therapy of type 2 diabetes.",
journal = "Materia medica",
title = "Uloga receptora aktiviranih proliferatorom peroksizoma u mehanizmu insulinske osetljivosti, Role of peroxisomal proliferators: Activated receptors in mechanism of insulin sensitivity",
volume = "26",
number = "1",
pages = "25-31",
url = "https://hdl.handle.net/21.15107/rcub_vinar_10329"
}
Soskić, S. S., Stanković, A., Isenović, E. R.,& Alavantić, D.. (2010). Uloga receptora aktiviranih proliferatorom peroksizoma u mehanizmu insulinske osetljivosti. in Materia medica, 26(1), 25-31.
https://hdl.handle.net/21.15107/rcub_vinar_10329
Soskić SS, Stanković A, Isenović ER, Alavantić D. Uloga receptora aktiviranih proliferatorom peroksizoma u mehanizmu insulinske osetljivosti. in Materia medica. 2010;26(1):25-31.
https://hdl.handle.net/21.15107/rcub_vinar_10329 .
Soskić, Sanja S., Stanković, Aleksandra, Isenović, Esma R., Alavantić, Dragan, "Uloga receptora aktiviranih proliferatorom peroksizoma u mehanizmu insulinske osetljivosti" in Materia medica, 26, no. 1 (2010):25-31,
https://hdl.handle.net/21.15107/rcub_vinar_10329 .

The IL-6-174G/C polymorphism and renal scarring in children with first acute pyelonephritis

Spasojević-Dimitrijeva, Brankica; Živković, Maja; Stanković, Aleksandra; Stojković, Ljiljana S.; Kostić, Mirjana M.

(2010)

TY  - JOUR
AU  - Spasojević-Dimitrijeva, Brankica
AU  - Živković, Maja
AU  - Stanković, Aleksandra
AU  - Stojković, Ljiljana S.
AU  - Kostić, Mirjana M.
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4085
AB  - Urinary tract infections (UTI) are common in infants and children and may result in serious complications, such as renal scarring, hypertension, and renal failure. Identification of the new markers in relation to acute pyelonephritis (APN) and its treatment is essential for designing interventions that would minimize tissue damage. This prospective study investigated the first UTI infection in 71 children (age range: 1-24 months) in respect to interleukin-6 (IL-6) -174G/C polymorphism and renal scarring. The patients were divided into an APN group and a lower UTI group according to dimercaptosuccinic acid (DMSA). The IL-6 -174G/C genotypes were determined by tetra-primer ARMSPCR. Serum IL-6 was significantly higher in the APN group than in the group with lower UTI (p LT 0.05). In both groups, the -174G/C genotype and allele frequencies did not differ significantly from the control group. The highest white blood cell (WBC) count was observed in the CC genotype (p LT 0.05). A non-significant trend toward higher serum IL-6 was observed in children with CC genotype. On follow-up DMSA imaging performed 6 months later, renal scarring was detected in 36.9% of APN children. We did not find the significant association of IL-6 -174G/C polymorphism with APN and/or postinfectious renal scarring. These results indicate that serum IL-6 concentrations were significantly higher in children with APN than in patients with lower UTI.
T2  - Pediatric Nephrology
T1  - The IL-6-174G/C polymorphism and renal scarring in children with first acute pyelonephritis
VL  - 25
IS  - 10
SP  - 2099
EP  - 2106
DO  - 10.1007/s00467-010-1587-x
ER  - 
@article{
author = "Spasojević-Dimitrijeva, Brankica and Živković, Maja and Stanković, Aleksandra and Stojković, Ljiljana S. and Kostić, Mirjana M.",
year = "2010",
abstract = "Urinary tract infections (UTI) are common in infants and children and may result in serious complications, such as renal scarring, hypertension, and renal failure. Identification of the new markers in relation to acute pyelonephritis (APN) and its treatment is essential for designing interventions that would minimize tissue damage. This prospective study investigated the first UTI infection in 71 children (age range: 1-24 months) in respect to interleukin-6 (IL-6) -174G/C polymorphism and renal scarring. The patients were divided into an APN group and a lower UTI group according to dimercaptosuccinic acid (DMSA). The IL-6 -174G/C genotypes were determined by tetra-primer ARMSPCR. Serum IL-6 was significantly higher in the APN group than in the group with lower UTI (p LT 0.05). In both groups, the -174G/C genotype and allele frequencies did not differ significantly from the control group. The highest white blood cell (WBC) count was observed in the CC genotype (p LT 0.05). A non-significant trend toward higher serum IL-6 was observed in children with CC genotype. On follow-up DMSA imaging performed 6 months later, renal scarring was detected in 36.9% of APN children. We did not find the significant association of IL-6 -174G/C polymorphism with APN and/or postinfectious renal scarring. These results indicate that serum IL-6 concentrations were significantly higher in children with APN than in patients with lower UTI.",
journal = "Pediatric Nephrology",
title = "The IL-6-174G/C polymorphism and renal scarring in children with first acute pyelonephritis",
volume = "25",
number = "10",
pages = "2099-2106",
doi = "10.1007/s00467-010-1587-x"
}
Spasojević-Dimitrijeva, B., Živković, M., Stanković, A., Stojković, L. S.,& Kostić, M. M.. (2010). The IL-6-174G/C polymorphism and renal scarring in children with first acute pyelonephritis. in Pediatric Nephrology, 25(10), 2099-2106.
https://doi.org/10.1007/s00467-010-1587-x
Spasojević-Dimitrijeva B, Živković M, Stanković A, Stojković LS, Kostić MM. The IL-6-174G/C polymorphism and renal scarring in children with first acute pyelonephritis. in Pediatric Nephrology. 2010;25(10):2099-2106.
doi:10.1007/s00467-010-1587-x .
Spasojević-Dimitrijeva, Brankica, Živković, Maja, Stanković, Aleksandra, Stojković, Ljiljana S., Kostić, Mirjana M., "The IL-6-174G/C polymorphism and renal scarring in children with first acute pyelonephritis" in Pediatric Nephrology, 25, no. 10 (2010):2099-2106,
https://doi.org/10.1007/s00467-010-1587-x . .
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Matrix metalloproteinase-9-1562 C/T gene polymorphism in Serbian patients with multiple sclerosis

Živković, Maja; Đurić, Tamara; Dinčić, Evica; Raičević, Ranko; Alavantić, Dragan; Stanković, Aleksandra

(2007)

TY  - JOUR
AU  - Živković, Maja
AU  - Đurić, Tamara
AU  - Dinčić, Evica
AU  - Raičević, Ranko
AU  - Alavantić, Dragan
AU  - Stanković, Aleksandra
PY  - 2007
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3299
AB  - Matrix metalloproteinase-9 (MMP-9) is suggested to play a role in MS by mediating T cell migration across subendothelial basement membrane and by contribution to myelin breakdown. We studied the association of MMP-9 -1562 C/T gene polymorphisms with MS susceptibility and severity in 187 patients from Serbia. The significant decrease in T allele carriership (p=0.01), was found in female NIS patients, In addition, a trend toward lower MSSS in T allele carriers was noticed (CC, mean 5.7 +/- 2.5 vs. CT+TT, mean 4.9 +/- 2.5). Further studies in different populations are needed to resolve the potential influence of MMP-9 gene polymorphism on MS. (C) 2007 Elsevier B.V. All rights reserved.
T2  - Journal of Neuroimmunology
T1  - Matrix metalloproteinase-9-1562 C/T gene polymorphism in Serbian patients with multiple sclerosis
VL  - 189
IS  - 1-2
SP  - 147
EP  - 150
DO  - 10.1016/j.jneuroim.2007.06.022
ER  - 
@article{
author = "Živković, Maja and Đurić, Tamara and Dinčić, Evica and Raičević, Ranko and Alavantić, Dragan and Stanković, Aleksandra",
year = "2007",
abstract = "Matrix metalloproteinase-9 (MMP-9) is suggested to play a role in MS by mediating T cell migration across subendothelial basement membrane and by contribution to myelin breakdown. We studied the association of MMP-9 -1562 C/T gene polymorphisms with MS susceptibility and severity in 187 patients from Serbia. The significant decrease in T allele carriership (p=0.01), was found in female NIS patients, In addition, a trend toward lower MSSS in T allele carriers was noticed (CC, mean 5.7 +/- 2.5 vs. CT+TT, mean 4.9 +/- 2.5). Further studies in different populations are needed to resolve the potential influence of MMP-9 gene polymorphism on MS. (C) 2007 Elsevier B.V. All rights reserved.",
journal = "Journal of Neuroimmunology",
title = "Matrix metalloproteinase-9-1562 C/T gene polymorphism in Serbian patients with multiple sclerosis",
volume = "189",
number = "1-2",
pages = "147-150",
doi = "10.1016/j.jneuroim.2007.06.022"
}
Živković, M., Đurić, T., Dinčić, E., Raičević, R., Alavantić, D.,& Stanković, A.. (2007). Matrix metalloproteinase-9-1562 C/T gene polymorphism in Serbian patients with multiple sclerosis. in Journal of Neuroimmunology, 189(1-2), 147-150.
https://doi.org/10.1016/j.jneuroim.2007.06.022
Živković M, Đurić T, Dinčić E, Raičević R, Alavantić D, Stanković A. Matrix metalloproteinase-9-1562 C/T gene polymorphism in Serbian patients with multiple sclerosis. in Journal of Neuroimmunology. 2007;189(1-2):147-150.
doi:10.1016/j.jneuroim.2007.06.022 .
Živković, Maja, Đurić, Tamara, Dinčić, Evica, Raičević, Ranko, Alavantić, Dragan, Stanković, Aleksandra, "Matrix metalloproteinase-9-1562 C/T gene polymorphism in Serbian patients with multiple sclerosis" in Journal of Neuroimmunology, 189, no. 1-2 (2007):147-150,
https://doi.org/10.1016/j.jneuroim.2007.06.022 . .
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Apolipoprotein B gene polymorphisms in patients from Serbia with ischemic cerebrovascular disease

Stanković, Aleksandra; Stanković, Sanja; Jovanovic-Markovic, Zagorka; Živković, Maja; Đurić, Tamara; Glišić, Sanja; Alavantić, Dragan

(2007)

TY  - JOUR
AU  - Stanković, Aleksandra
AU  - Stanković, Sanja
AU  - Jovanovic-Markovic, Zagorka
AU  - Živković, Maja
AU  - Đurić, Tamara
AU  - Glišić, Sanja
AU  - Alavantić, Dragan
PY  - 2007
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3419
AB  - The plasma concentration of apoB has recently been reported to be the best lipid predictor of coronary heart disease. The possible associations of genetic markers in the apolipoprotein B gene (Xbal, EcoRI, MspI, Ins/Del, and 4311 A/G polymorphisms) were evaluated in patients with ischemic cerebrovascular disease (ICVD) and controls of equivalent BMI. The odds ratio for ICVD in the X+X+ genotype was 2.22, 95% CI 1.24-3.96 (P LT 0.05), while that for ICVD in the Ins/Ins genotype was 2.82, 95% CI 1.57-5.06 (P LT 0.05). The patients had significantly higher frequency of the 4311 A allele compared to the controls (P LT 0.01). Our results support the assumption that apoB gene polymorphisms may contribute to the extent of cerebrovascular disease risk.
T2  - Archives of Biological Sciences
T1  - Apolipoprotein B gene polymorphisms in patients from Serbia with ischemic cerebrovascular disease
VL  - 59
IS  - 4
SP  - 303
EP  - 309
DO  - 10.2298/ABS0704303S
ER  - 
@article{
author = "Stanković, Aleksandra and Stanković, Sanja and Jovanovic-Markovic, Zagorka and Živković, Maja and Đurić, Tamara and Glišić, Sanja and Alavantić, Dragan",
year = "2007",
abstract = "The plasma concentration of apoB has recently been reported to be the best lipid predictor of coronary heart disease. The possible associations of genetic markers in the apolipoprotein B gene (Xbal, EcoRI, MspI, Ins/Del, and 4311 A/G polymorphisms) were evaluated in patients with ischemic cerebrovascular disease (ICVD) and controls of equivalent BMI. The odds ratio for ICVD in the X+X+ genotype was 2.22, 95% CI 1.24-3.96 (P LT 0.05), while that for ICVD in the Ins/Ins genotype was 2.82, 95% CI 1.57-5.06 (P LT 0.05). The patients had significantly higher frequency of the 4311 A allele compared to the controls (P LT 0.01). Our results support the assumption that apoB gene polymorphisms may contribute to the extent of cerebrovascular disease risk.",
journal = "Archives of Biological Sciences",
title = "Apolipoprotein B gene polymorphisms in patients from Serbia with ischemic cerebrovascular disease",
volume = "59",
number = "4",
pages = "303-309",
doi = "10.2298/ABS0704303S"
}
Stanković, A., Stanković, S., Jovanovic-Markovic, Z., Živković, M., Đurić, T., Glišić, S.,& Alavantić, D.. (2007). Apolipoprotein B gene polymorphisms in patients from Serbia with ischemic cerebrovascular disease. in Archives of Biological Sciences, 59(4), 303-309.
https://doi.org/10.2298/ABS0704303S
Stanković A, Stanković S, Jovanovic-Markovic Z, Živković M, Đurić T, Glišić S, Alavantić D. Apolipoprotein B gene polymorphisms in patients from Serbia with ischemic cerebrovascular disease. in Archives of Biological Sciences. 2007;59(4):303-309.
doi:10.2298/ABS0704303S .
Stanković, Aleksandra, Stanković, Sanja, Jovanovic-Markovic, Zagorka, Živković, Maja, Đurić, Tamara, Glišić, Sanja, Alavantić, Dragan, "Apolipoprotein B gene polymorphisms in patients from Serbia with ischemic cerebrovascular disease" in Archives of Biological Sciences, 59, no. 4 (2007):303-309,
https://doi.org/10.2298/ABS0704303S . .
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Association of ACE I/D and MMP-3 5A/6A gene polymorphisms with hypertension in men from Serbia

Živković, Maja; Đurić, Tamara; Alavantić, Dragan; Mecanin, Sanja; Stanković, Aleksandra

(2006)

TY  - JOUR
AU  - Živković, Maja
AU  - Đurić, Tamara
AU  - Alavantić, Dragan
AU  - Mecanin, Sanja
AU  - Stanković, Aleksandra
PY  - 2006
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12037
AB  - The ACE and MMP-3 loci are involved in the vascular remodeling, increased intima media thickness and arterial stiffness associated with hypertension. We determined ACE I/D and MMP-3 5A/6A gene polymorphisms in 231 Caucasian males (126/105, hypertensive/normotensive). Owing to age-related differences hypertension, the sample was truncated with respect to age (the cut-off point was the age of 40). Our results indicate that ACE I/D and MMP-3 5A/6A polymorphisms are likely to be risk factors for hypertension in men from Serbia = 40 years of age. In the same group, the combined effect of DD/6A+ genotypes on hypertension was more pronounced than their separate effect.
AB  - ACE и MMP-3 су укључени у процесе ремоделовања зида крвних судова, задебљања интима-медије и губитка еластичности артерија који су повезани са хипертензијом. Утврђивање генотипова полиморфизама I/D и 5A/6A у генима за ACE и MMP-3 је урађено на узорку од 231 мушкарца, Кавказоида (126/105, хипертензивни/нормотензивни). Обзиром на повезаност настанка хипертензије са годинама старости испитивана популација је подељена у две старосне групе (до и преко 40-е године старости). Наши резултати указују да су полиморфизми у генима за ACE (I/D) и MMP-3 (5A/6A) могући фактори ризика за настанак хипертензије код мушкараца = 40 година старости у популацији Србије. У истој старосној групи заједнички утицај генотипова DD/6A+ на настанак хипертензије је био већи од њиховог појединачног утицаја.
T2  - Archives of Biological Sciences
T1  - Association of ACE I/D and MMP-3 5A/6A gene polymorphisms with hypertension in men from Serbia
T1  - Асоцијација полиморфизама I/D и 5A/6A у генима за ACE и MMP-3 СА хипертензијом код мушкараца у Србији
VL  - 58
IS  - 4
SP  - 205
EP  - 210
DO  - 10.2298/ABS0604205Z
ER  - 
@article{
author = "Živković, Maja and Đurić, Tamara and Alavantić, Dragan and Mecanin, Sanja and Stanković, Aleksandra",
year = "2006",
abstract = "The ACE and MMP-3 loci are involved in the vascular remodeling, increased intima media thickness and arterial stiffness associated with hypertension. We determined ACE I/D and MMP-3 5A/6A gene polymorphisms in 231 Caucasian males (126/105, hypertensive/normotensive). Owing to age-related differences hypertension, the sample was truncated with respect to age (the cut-off point was the age of 40). Our results indicate that ACE I/D and MMP-3 5A/6A polymorphisms are likely to be risk factors for hypertension in men from Serbia = 40 years of age. In the same group, the combined effect of DD/6A+ genotypes on hypertension was more pronounced than their separate effect., ACE и MMP-3 су укључени у процесе ремоделовања зида крвних судова, задебљања интима-медије и губитка еластичности артерија који су повезани са хипертензијом. Утврђивање генотипова полиморфизама I/D и 5A/6A у генима за ACE и MMP-3 је урађено на узорку од 231 мушкарца, Кавказоида (126/105, хипертензивни/нормотензивни). Обзиром на повезаност настанка хипертензије са годинама старости испитивана популација је подељена у две старосне групе (до и преко 40-е године старости). Наши резултати указују да су полиморфизми у генима за ACE (I/D) и MMP-3 (5A/6A) могући фактори ризика за настанак хипертензије код мушкараца = 40 година старости у популацији Србије. У истој старосној групи заједнички утицај генотипова DD/6A+ на настанак хипертензије је био већи од њиховог појединачног утицаја.",
journal = "Archives of Biological Sciences",
title = "Association of ACE I/D and MMP-3 5A/6A gene polymorphisms with hypertension in men from Serbia, Асоцијација полиморфизама I/D и 5A/6A у генима за ACE и MMP-3 СА хипертензијом код мушкараца у Србији",
volume = "58",
number = "4",
pages = "205-210",
doi = "10.2298/ABS0604205Z"
}
Živković, M., Đurić, T., Alavantić, D., Mecanin, S.,& Stanković, A.. (2006). Association of ACE I/D and MMP-3 5A/6A gene polymorphisms with hypertension in men from Serbia. in Archives of Biological Sciences, 58(4), 205-210.
https://doi.org/10.2298/ABS0604205Z
Živković M, Đurić T, Alavantić D, Mecanin S, Stanković A. Association of ACE I/D and MMP-3 5A/6A gene polymorphisms with hypertension in men from Serbia. in Archives of Biological Sciences. 2006;58(4):205-210.
doi:10.2298/ABS0604205Z .
Živković, Maja, Đurić, Tamara, Alavantić, Dragan, Mecanin, Sanja, Stanković, Aleksandra, "Association of ACE I/D and MMP-3 5A/6A gene polymorphisms with hypertension in men from Serbia" in Archives of Biological Sciences, 58, no. 4 (2006):205-210,
https://doi.org/10.2298/ABS0604205Z . .
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