TY  - JOUR
AU  - Fdez-Arroyabe, Pablo
AU  - Kourtidis, Konstantinos
AU  - Haldoupis, Christos
AU  - Savoska, Snezana
AU  - Matthews, James
AU  - Mir, Lluis M.
AU  - Kassomenos, Pavlos
AU  - Cifra, Michal
AU  - Barbosa, Susana
AU  - Chen, Xuemeng
AU  - Dragović, Snežana D.
AU  - Consoulas, Christos
AU  - Hunting, Ellard R.
AU  - Robert, Daniel
AU  - van der Velde, Oscar A.
AU  - Apollonio, Francesca
AU  - Odzimek, Anna
AU  - Chilingarian, Ashot
AU  - Royé, Dominic
AU  - Mkrtchyan, Hripsime
AU  - Price, Colin
AU  - Bór, József
AU  - Oikonomou, Christina
AU  - Birsan, Marius-Victor
AU  - Crespo-Facorro, Benedicto
AU  - Đorđević, Milan
AU  - Salcines, Ciro
AU  - López-Jiménez, Amparo
AU  - Donner, Reik V.
AU  - Vana, Marko
AU  - Pedersen, Jens Olaf Pepke
AU  - Vorenhout, Michel
AU  - Rycroft, Michael
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9673
AB  - There is an increasing interest to study the interactions between atmospheric electrical parameters and living organisms at multiple scales. So far, relatively few studies have been published that focus on possible biological effects of atmospheric electric and magnetic fields. To foster future work in this area of multidisciplinary research, here we present a glossary of relevant terms. Its main purpose is to facilitate the process of learning and communication among the different scientific disciplines working on this topic. While some definitions come from existing sources, other concepts have been re-defined to better reflect the existing and emerging scientific needs of this multidisciplinary and transdisciplinary area of research.
T2  - International Journal of Biometeorology
T1  - Glossary on atmospheric electricity and its effects on biology
VL  - 65
IS  - 1
SP  - 5
EP  - 29
DO  - 10.1007/s00484-020-02013-9
ER  - 

@article{
author = "Fdez-Arroyabe, Pablo and Kourtidis, Konstantinos and Haldoupis, Christos and Savoska, Snezana and Matthews, James and Mir, Lluis M. and Kassomenos, Pavlos and Cifra, Michal and Barbosa, Susana and Chen, Xuemeng and Dragović, Snežana D. and Consoulas, Christos and Hunting, Ellard R. and Robert, Daniel and van der Velde, Oscar A. and Apollonio, Francesca and Odzimek, Anna and Chilingarian, Ashot and Royé, Dominic and Mkrtchyan, Hripsime and Price, Colin and Bór, József and Oikonomou, Christina and Birsan, Marius-Victor and Crespo-Facorro, Benedicto and Đorđević, Milan and Salcines, Ciro and López-Jiménez, Amparo and Donner, Reik V. and Vana, Marko and Pedersen, Jens Olaf Pepke and Vorenhout, Michel and Rycroft, Michael",
year = "2021",
abstract = "There is an increasing interest to study the interactions between atmospheric electrical parameters and living organisms at multiple scales. So far, relatively few studies have been published that focus on possible biological effects of atmospheric electric and magnetic fields. To foster future work in this area of multidisciplinary research, here we present a glossary of relevant terms. Its main purpose is to facilitate the process of learning and communication among the different scientific disciplines working on this topic. While some definitions come from existing sources, other concepts have been re-defined to better reflect the existing and emerging scientific needs of this multidisciplinary and transdisciplinary area of research.",
journal = "International Journal of Biometeorology",
title = "Glossary on atmospheric electricity and its effects on biology",
volume = "65",
number = "1",
pages = "5-29",
doi = "10.1007/s00484-020-02013-9"
}

Fdez-Arroyabe, P., Kourtidis, K., Haldoupis, C., Savoska, S., Matthews, J., Mir, L. M., Kassomenos, P., Cifra, M., Barbosa, S., Chen, X., Dragović, S. D., Consoulas, C., Hunting, E. R., Robert, D., van der Velde, O. A., Apollonio, F., Odzimek, A., Chilingarian, A., Royé, D., Mkrtchyan, H., Price, C., Bór, J., Oikonomou, C., Birsan, M., Crespo-Facorro, B., Đorđević, M., Salcines, C., López-Jiménez, A., Donner, R. V., Vana, M., Pedersen, J. O. P., Vorenhout, M.,& Rycroft, M.. (2021). Glossary on atmospheric electricity and its effects on biology. in International Journal of Biometeorology, 65(1), 5-29.
https://doi.org/10.1007/s00484-020-02013-9

Fdez-Arroyabe P, Kourtidis K, Haldoupis C, Savoska S, Matthews J, Mir LM, Kassomenos P, Cifra M, Barbosa S, Chen X, Dragović SD, Consoulas C, Hunting ER, Robert D, van der Velde OA, Apollonio F, Odzimek A, Chilingarian A, Royé D, Mkrtchyan H, Price C, Bór J, Oikonomou C, Birsan M, Crespo-Facorro B, Đorđević M, Salcines C, López-Jiménez A, Donner RV, Vana M, Pedersen JOP, Vorenhout M, Rycroft M. Glossary on atmospheric electricity and its effects on biology. in International Journal of Biometeorology. 2021;65(1):5-29.
doi:10.1007/s00484-020-02013-9 .

Fdez-Arroyabe, Pablo, Kourtidis, Konstantinos, Haldoupis, Christos, Savoska, Snezana, Matthews, James, Mir, Lluis M., Kassomenos, Pavlos, Cifra, Michal, Barbosa, Susana, Chen, Xuemeng, Dragović, Snežana D., Consoulas, Christos, Hunting, Ellard R., Robert, Daniel, van der Velde, Oscar A., Apollonio, Francesca, Odzimek, Anna, Chilingarian, Ashot, Royé, Dominic, Mkrtchyan, Hripsime, Price, Colin, Bór, József, Oikonomou, Christina, Birsan, Marius-Victor, Crespo-Facorro, Benedicto, Đorđević, Milan, Salcines, Ciro, López-Jiménez, Amparo, Donner, Reik V., Vana, Marko, Pedersen, Jens Olaf Pepke, Vorenhout, Michel, Rycroft, Michael, "Glossary on atmospheric electricity and its effects on biology" in International Journal of Biometeorology, 65, no. 1 (2021):5-29,
https://doi.org/10.1007/s00484-020-02013-9 . .

TY  - JOUR
AU  - Jovanović, Mirna
AU  - Zhukovsky, Daniil
AU  - Podolski-Renić, Ana
AU  - Domračeva, Ilona
AU  - Žalubovskis, Raivis
AU  - Senćanski, Milan V.
AU  - Glišić, Sanja
AU  - Sharoyko, Vladimir
AU  - Tennikova, Tatiana
AU  - Dar'in, Dmitry
AU  - Pešić, Milica
AU  - Krasavin, Mikhail
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8532
AB  - A series of peptidomimetic compounds incorporating an electrophilic moiety was synthesized using the Ugi reaction. These compounds (termed the Ugi Michael acceptors or UMAs) were designed to target the selenocysteine catalytic residue of thioredoxin reductase 1 (TrxR1), a promising cancer target. The compounds were assessed for their potential to inhibit TrxR1 using human neuroblastoma (SH-SY5Y) cell lysate. Based on this initial screening, six compounds were selected for testing against recombinant rat TrxR1 and in the insulin assay to reveal low-micromolar to submicromolar potency of these inhibitors. The same frontrunner compounds were evaluated for their ability to exert antiproliferative activity and induce cell death and this activity was compared to the UMA effects on the levels of reactive oxygen and nitrogen species (RONS). Collectively, the UMA compounds class presented itself as a rich source of leads for TrxR1 inhibitor discovery for anticancer application. Compound 7 (DVD-445) was nominated a lead for further optimization. © 2019 Elsevier Masson SAS
T2  - European Journal of Medicinal Chemistry
T1  - Novel electrophilic amides amenable by the Ugi reaction perturb thioredoxin system via thioredoxin reductase 1 (TrxR1) inhibition: Identification of DVD-445 as a new lead compound for anticancer therapy
VL  - 181
SP  - 111580
DO  - 10.1016/j.ejmech.2019.111580
ER  - 

@article{
author = "Jovanović, Mirna and Zhukovsky, Daniil and Podolski-Renić, Ana and Domračeva, Ilona and Žalubovskis, Raivis and Senćanski, Milan V. and Glišić, Sanja and Sharoyko, Vladimir and Tennikova, Tatiana and Dar'in, Dmitry and Pešić, Milica and Krasavin, Mikhail",
year = "2019",
abstract = "A series of peptidomimetic compounds incorporating an electrophilic moiety was synthesized using the Ugi reaction. These compounds (termed the Ugi Michael acceptors or UMAs) were designed to target the selenocysteine catalytic residue of thioredoxin reductase 1 (TrxR1), a promising cancer target. The compounds were assessed for their potential to inhibit TrxR1 using human neuroblastoma (SH-SY5Y) cell lysate. Based on this initial screening, six compounds were selected for testing against recombinant rat TrxR1 and in the insulin assay to reveal low-micromolar to submicromolar potency of these inhibitors. The same frontrunner compounds were evaluated for their ability to exert antiproliferative activity and induce cell death and this activity was compared to the UMA effects on the levels of reactive oxygen and nitrogen species (RONS). Collectively, the UMA compounds class presented itself as a rich source of leads for TrxR1 inhibitor discovery for anticancer application. Compound 7 (DVD-445) was nominated a lead for further optimization. © 2019 Elsevier Masson SAS",
journal = "European Journal of Medicinal Chemistry",
title = "Novel electrophilic amides amenable by the Ugi reaction perturb thioredoxin system via thioredoxin reductase 1 (TrxR1) inhibition: Identification of DVD-445 as a new lead compound for anticancer therapy",
volume = "181",
pages = "111580",
doi = "10.1016/j.ejmech.2019.111580"
}

Jovanović, M., Zhukovsky, D., Podolski-Renić, A., Domračeva, I., Žalubovskis, R., Senćanski, M. V., Glišić, S., Sharoyko, V., Tennikova, T., Dar'in, D., Pešić, M.,& Krasavin, M.. (2019). Novel electrophilic amides amenable by the Ugi reaction perturb thioredoxin system via thioredoxin reductase 1 (TrxR1) inhibition: Identification of DVD-445 as a new lead compound for anticancer therapy. in European Journal of Medicinal Chemistry, 181, 111580.
https://doi.org/10.1016/j.ejmech.2019.111580

Jovanović M, Zhukovsky D, Podolski-Renić A, Domračeva I, Žalubovskis R, Senćanski MV, Glišić S, Sharoyko V, Tennikova T, Dar'in D, Pešić M, Krasavin M. Novel electrophilic amides amenable by the Ugi reaction perturb thioredoxin system via thioredoxin reductase 1 (TrxR1) inhibition: Identification of DVD-445 as a new lead compound for anticancer therapy. in European Journal of Medicinal Chemistry. 2019;181:111580.
doi:10.1016/j.ejmech.2019.111580 .

Jovanović, Mirna, Zhukovsky, Daniil, Podolski-Renić, Ana, Domračeva, Ilona, Žalubovskis, Raivis, Senćanski, Milan V., Glišić, Sanja, Sharoyko, Vladimir, Tennikova, Tatiana, Dar'in, Dmitry, Pešić, Milica, Krasavin, Mikhail, "Novel electrophilic amides amenable by the Ugi reaction perturb thioredoxin system via thioredoxin reductase 1 (TrxR1) inhibition: Identification of DVD-445 as a new lead compound for anticancer therapy" in European Journal of Medicinal Chemistry, 181 (2019):111580,
https://doi.org/10.1016/j.ejmech.2019.111580 . .