TY  - JOUR
AU  - Đurđić, Slađana
AU  - Stanković, Vesna
AU  - Perić, Marko R.
AU  - Ognjanović, Miloš
AU  - Švorc, Lubomir
AU  - Mutić, Jelena J.
AU  - Stanković, Dalibor M.
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8615
AB  - In present work boron doped diamond (BDD) electrode was applied for studying electrochemical behavior, as well as for quantitative determination of natural alkaloid, tubocurarine (arrow poison/ TUB). Electrochemical behavior was investigated using several organic solvents and aqueous buffers, at different pHs, as supporting electrolytes. After selection of the most appropriate supporting electrolyte and investigation of its electrochemical behavior, analytical procedures for quantitative analysis of TUB were developed in an acetonitrile/methanol (80:20) mixture and in 1 mol L−1 nitric acid, which had linear quantification ranges from 4 × 10−6 to 1 × 10−4 mol L−1 (LOD = 3.07 × 10−6 mol L−1) and 4 × 10−6 to 9 × 10−5 mol L−1 (LOD = 2.45 × 10−6 mol L−1 and 5.28 × 10−7 mol L−1, depending on the selected peak), respectively. The oxidation mechanism of TUB was proposed from the theoretical aspect. Remarkable selectivity and good sensitivity were obtained after the TUB quantification method was optimized, allowing application of the developed method for TUB quantification in biological fluids, with excellent reproducibility, accuracy and precision.
T2  - Journal of The Electrochemical Society
T1  - Electrochemistry of the Arrow Poison, Tubocurarine, Using Boron Doped Diamond Electrode: Experimental and Theoretical Approaches
VL  - 166
IS  - 14
SP  - G157
EP  - G161
DO  - 10.1149/2.1241914jes
ER  - 

@article{
author = "Đurđić, Slađana and Stanković, Vesna and Perić, Marko R. and Ognjanović, Miloš and Švorc, Lubomir and Mutić, Jelena J. and Stanković, Dalibor M.",
year = "2019",
abstract = "In present work boron doped diamond (BDD) electrode was applied for studying electrochemical behavior, as well as for quantitative determination of natural alkaloid, tubocurarine (arrow poison/ TUB). Electrochemical behavior was investigated using several organic solvents and aqueous buffers, at different pHs, as supporting electrolytes. After selection of the most appropriate supporting electrolyte and investigation of its electrochemical behavior, analytical procedures for quantitative analysis of TUB were developed in an acetonitrile/methanol (80:20) mixture and in 1 mol L−1 nitric acid, which had linear quantification ranges from 4 × 10−6 to 1 × 10−4 mol L−1 (LOD = 3.07 × 10−6 mol L−1) and 4 × 10−6 to 9 × 10−5 mol L−1 (LOD = 2.45 × 10−6 mol L−1 and 5.28 × 10−7 mol L−1, depending on the selected peak), respectively. The oxidation mechanism of TUB was proposed from the theoretical aspect. Remarkable selectivity and good sensitivity were obtained after the TUB quantification method was optimized, allowing application of the developed method for TUB quantification in biological fluids, with excellent reproducibility, accuracy and precision.",
journal = "Journal of The Electrochemical Society",
title = "Electrochemistry of the Arrow Poison, Tubocurarine, Using Boron Doped Diamond Electrode: Experimental and Theoretical Approaches",
volume = "166",
number = "14",
pages = "G157-G161",
doi = "10.1149/2.1241914jes"
}

Đurđić, S., Stanković, V., Perić, M. R., Ognjanović, M., Švorc, L., Mutić, J. J.,& Stanković, D. M.. (2019). Electrochemistry of the Arrow Poison, Tubocurarine, Using Boron Doped Diamond Electrode: Experimental and Theoretical Approaches. in Journal of The Electrochemical Society, 166(14), G157-G161.
https://doi.org/10.1149/2.1241914jes

Đurđić S, Stanković V, Perić MR, Ognjanović M, Švorc L, Mutić JJ, Stanković DM. Electrochemistry of the Arrow Poison, Tubocurarine, Using Boron Doped Diamond Electrode: Experimental and Theoretical Approaches. in Journal of The Electrochemical Society. 2019;166(14):G157-G161.
doi:10.1149/2.1241914jes .

Đurđić, Slađana, Stanković, Vesna, Perić, Marko R., Ognjanović, Miloš, Švorc, Lubomir, Mutić, Jelena J., Stanković, Dalibor M., "Electrochemistry of the Arrow Poison, Tubocurarine, Using Boron Doped Diamond Electrode: Experimental and Theoretical Approaches" in Journal of The Electrochemical Society, 166, no. 14 (2019):G157-G161,
https://doi.org/10.1149/2.1241914jes . .

TY  - JOUR
AU  - Cinkova, Kristina
AU  - Kianičkova, Kristina
AU  - Stanković, Dalibor M.
AU  - Vojs, Marian
AU  - Marton, Marian
AU  - Švorc, Lubomir
PY  - 2018
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7662
AB  - In this work, the electrochemical oxidation and subsequent determination of uric acid was investigated using boron-doped diamond electrodes with various B/C ratios (0-2000 ppm). The cyclic voltammetric study showed one irreversible oxidation peak at +(1.1-1.25) V (vs. Ag/AgCl/3 M KCl) in the presence of Britton-Robinson buffer (pH 2.25) depending on the boron content. Employing differential pulse voltammetry using the 2000 ppm boron-doped diamond electrode the acquired analytical parameters were as follows: a limit of detection of 7.7 M, a limit of quantification of 26 M and intra-day repeatability (relative standard deviation of 2.9% for n = 15). After performing an interference study, the method was applied to the determination of uric acid in biological samples (human urine). The uric acid concentrations determined in the urine samples were compared with the reference values stated in the literature. The proposed methodology using boron-doped diamond electrodes could find applications in uric acid sensing within clinical, pharmaceutical and environmental analysis.
T2  - Analytical Methods
T1  - The doping level of boron-doped diamond electrodes affects the voltammetric sensing of uric acid
VL  - 10
IS  - 9
SP  - 991
EP  - 996
DO  - 10.1039/C7AY02720F
ER  - 

@article{
author = "Cinkova, Kristina and Kianičkova, Kristina and Stanković, Dalibor M. and Vojs, Marian and Marton, Marian and Švorc, Lubomir",
year = "2018",
abstract = "In this work, the electrochemical oxidation and subsequent determination of uric acid was investigated using boron-doped diamond electrodes with various B/C ratios (0-2000 ppm). The cyclic voltammetric study showed one irreversible oxidation peak at +(1.1-1.25) V (vs. Ag/AgCl/3 M KCl) in the presence of Britton-Robinson buffer (pH 2.25) depending on the boron content. Employing differential pulse voltammetry using the 2000 ppm boron-doped diamond electrode the acquired analytical parameters were as follows: a limit of detection of 7.7 M, a limit of quantification of 26 M and intra-day repeatability (relative standard deviation of 2.9% for n = 15). After performing an interference study, the method was applied to the determination of uric acid in biological samples (human urine). The uric acid concentrations determined in the urine samples were compared with the reference values stated in the literature. The proposed methodology using boron-doped diamond electrodes could find applications in uric acid sensing within clinical, pharmaceutical and environmental analysis.",
journal = "Analytical Methods",
title = "The doping level of boron-doped diamond electrodes affects the voltammetric sensing of uric acid",
volume = "10",
number = "9",
pages = "991-996",
doi = "10.1039/C7AY02720F"
}

Cinkova, K., Kianičkova, K., Stanković, D. M., Vojs, M., Marton, M.,& Švorc, L.. (2018). The doping level of boron-doped diamond electrodes affects the voltammetric sensing of uric acid. in Analytical Methods, 10(9), 991-996.
https://doi.org/10.1039/C7AY02720F

Cinkova K, Kianičkova K, Stanković DM, Vojs M, Marton M, Švorc L. The doping level of boron-doped diamond electrodes affects the voltammetric sensing of uric acid. in Analytical Methods. 2018;10(9):991-996.
doi:10.1039/C7AY02720F .

Cinkova, Kristina, Kianičkova, Kristina, Stanković, Dalibor M., Vojs, Marian, Marton, Marian, Švorc, Lubomir, "The doping level of boron-doped diamond electrodes affects the voltammetric sensing of uric acid" in Analytical Methods, 10, no. 9 (2018):991-996,
https://doi.org/10.1039/C7AY02720F . .

TY  - JOUR
AU  - Samiec, Petr
AU  - Švorc, Lubomir
AU  - Stanković, Dalibor M.
AU  - Vojs, Marian
AU  - Marton, Marian
AU  - Navratilova, Zuzana
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8853
AB  - The boron-doped diamond electrodes (BDDEs) with different dopant levels were applied as advanced, mercury-free and modification-free electroanalytical platforms for simple and reliable quantification of benzodiazepines, bromazepam (BZ) and alprazolam (ALZ). Cyclic voltammetric measurements revealed that the electrode reactions of both analytes were manifested by one irreversible and diffusion-controlled reduction peak at -1.10V in Britton-Robinson buffer of pH 11 for BZ using lab-made BDDE with 1000 ppm B/C ratio and -0.84V in BR buffer of pH 5 for ALZ using commercial BDDE with 1000 ppm B/C ratio. Differential pulse voltammetry was used for construction of calibration curves for BZ and ALZ, respectively, with the analytical parameters as follows: the linear dynamic ranges of 1 x 10(-6)-1 x 10(-4) and 8 x 10(-7)-1 x 10(-4) mol/L, the detection limit of 3.1 x 10(-7) and 6.4 x 10(-7) mol/L and the excellent repeatability with the relative standard deviation below 3% for both drugs. The developed methods were applied to analysis of the pharmaceutical tablets with the recoveries from 97.33 to 100.85% for BZ and from 94.14 to 101.32% for ALZ. The usage of BDDEs as advanced electrochemical sensors in drug analysis represents a facile and effective analytical approach which may replace mercury-based sensors and chemically modified electrodes in previous benzodiazepines sensing. (C) 2017 Elsevier B.V. All rights reserved.
T2  - Sensors and Actuators B: Chemical
T1  - Mercury-free and modification-free electroanalytical approach towards bromazepam and alprazolam sensing: A facile and efficient assay for their quantification in pharmaceuticals using boron-doped diamond electrodes
VL  - 245
SP  - 963
EP  - 971
DO  - 10.1016/j.snb.2017.02.023
ER  - 

@article{
author = "Samiec, Petr and Švorc, Lubomir and Stanković, Dalibor M. and Vojs, Marian and Marton, Marian and Navratilova, Zuzana",
year = "2017",
abstract = "The boron-doped diamond electrodes (BDDEs) with different dopant levels were applied as advanced, mercury-free and modification-free electroanalytical platforms for simple and reliable quantification of benzodiazepines, bromazepam (BZ) and alprazolam (ALZ). Cyclic voltammetric measurements revealed that the electrode reactions of both analytes were manifested by one irreversible and diffusion-controlled reduction peak at -1.10V in Britton-Robinson buffer of pH 11 for BZ using lab-made BDDE with 1000 ppm B/C ratio and -0.84V in BR buffer of pH 5 for ALZ using commercial BDDE with 1000 ppm B/C ratio. Differential pulse voltammetry was used for construction of calibration curves for BZ and ALZ, respectively, with the analytical parameters as follows: the linear dynamic ranges of 1 x 10(-6)-1 x 10(-4) and 8 x 10(-7)-1 x 10(-4) mol/L, the detection limit of 3.1 x 10(-7) and 6.4 x 10(-7) mol/L and the excellent repeatability with the relative standard deviation below 3% for both drugs. The developed methods were applied to analysis of the pharmaceutical tablets with the recoveries from 97.33 to 100.85% for BZ and from 94.14 to 101.32% for ALZ. The usage of BDDEs as advanced electrochemical sensors in drug analysis represents a facile and effective analytical approach which may replace mercury-based sensors and chemically modified electrodes in previous benzodiazepines sensing. (C) 2017 Elsevier B.V. All rights reserved.",
journal = "Sensors and Actuators B: Chemical",
title = "Mercury-free and modification-free electroanalytical approach towards bromazepam and alprazolam sensing: A facile and efficient assay for their quantification in pharmaceuticals using boron-doped diamond electrodes",
volume = "245",
pages = "963-971",
doi = "10.1016/j.snb.2017.02.023"
}

Samiec, P., Švorc, L., Stanković, D. M., Vojs, M., Marton, M.,& Navratilova, Z.. (2017). Mercury-free and modification-free electroanalytical approach towards bromazepam and alprazolam sensing: A facile and efficient assay for their quantification in pharmaceuticals using boron-doped diamond electrodes. in Sensors and Actuators B: Chemical, 245, 963-971.
https://doi.org/10.1016/j.snb.2017.02.023

Samiec P, Švorc L, Stanković DM, Vojs M, Marton M, Navratilova Z. Mercury-free and modification-free electroanalytical approach towards bromazepam and alprazolam sensing: A facile and efficient assay for their quantification in pharmaceuticals using boron-doped diamond electrodes. in Sensors and Actuators B: Chemical. 2017;245:963-971.
doi:10.1016/j.snb.2017.02.023 .

Samiec, Petr, Švorc, Lubomir, Stanković, Dalibor M., Vojs, Marian, Marton, Marian, Navratilova, Zuzana, "Mercury-free and modification-free electroanalytical approach towards bromazepam and alprazolam sensing: A facile and efficient assay for their quantification in pharmaceuticals using boron-doped diamond electrodes" in Sensors and Actuators B: Chemical, 245 (2017):963-971,
https://doi.org/10.1016/j.snb.2017.02.023 . .

TY  - JOUR
AU  - Stanković, Dalibor M.
AU  - Ognjanović, Miloš
AU  - Fabian, Martin
AU  - Švorc, Lubomir
AU  - Mariano, Jose F. M. L.
AU  - Antić, Bratislav
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1853
AB  - In the present paper, the electrochemical behavior and the properties of two modified glassy carbon (GC) electrodes used for quantification of gallic acid in sweet wines were compared. A comparative study was conducted between titanium nitride- or wolfram carbide-doped reduced graphene oxide, labeled as TNrGO and WCrGO, respectively, modified GC electrodes, which are promising composite nanomaterials for electroanalytical applications. For the first time, WCrGO was synthesized and its electroanalytical properties compared with those of TNrGO. Results showed that the proposed materials exhibited enhanced characteristics, e.g., low limits of detection (1.1 mu M and 3.1 mu M for TNrGO and WCrGO, respectively), wide linear ranges (for TNrGO 4.5-76 mu M and for WCrGO 10-100 mu M), low adsorption, and low background current, which make them promising candidates for electrochemical sensing applications.
T2  - Analytical Biochemistry
T1  - Design of titanium nitride- and wolfram carbide-doped RGO/GC electrodes for determination of gallic acid
VL  - 539
SP  - 104
EP  - 112
DO  - 10.1016/j.ab.2017.10.018
ER  - 

@article{
author = "Stanković, Dalibor M. and Ognjanović, Miloš and Fabian, Martin and Švorc, Lubomir and Mariano, Jose F. M. L. and Antić, Bratislav",
year = "2017",
abstract = "In the present paper, the electrochemical behavior and the properties of two modified glassy carbon (GC) electrodes used for quantification of gallic acid in sweet wines were compared. A comparative study was conducted between titanium nitride- or wolfram carbide-doped reduced graphene oxide, labeled as TNrGO and WCrGO, respectively, modified GC electrodes, which are promising composite nanomaterials for electroanalytical applications. For the first time, WCrGO was synthesized and its electroanalytical properties compared with those of TNrGO. Results showed that the proposed materials exhibited enhanced characteristics, e.g., low limits of detection (1.1 mu M and 3.1 mu M for TNrGO and WCrGO, respectively), wide linear ranges (for TNrGO 4.5-76 mu M and for WCrGO 10-100 mu M), low adsorption, and low background current, which make them promising candidates for electrochemical sensing applications.",
journal = "Analytical Biochemistry",
title = "Design of titanium nitride- and wolfram carbide-doped RGO/GC electrodes for determination of gallic acid",
volume = "539",
pages = "104-112",
doi = "10.1016/j.ab.2017.10.018"
}

Stanković, D. M., Ognjanović, M., Fabian, M., Švorc, L., Mariano, J. F. M. L.,& Antić, B.. (2017). Design of titanium nitride- and wolfram carbide-doped RGO/GC electrodes for determination of gallic acid. in Analytical Biochemistry, 539, 104-112.
https://doi.org/10.1016/j.ab.2017.10.018

Stanković DM, Ognjanović M, Fabian M, Švorc L, Mariano JFML, Antić B. Design of titanium nitride- and wolfram carbide-doped RGO/GC electrodes for determination of gallic acid. in Analytical Biochemistry. 2017;539:104-112.
doi:10.1016/j.ab.2017.10.018 .

Stanković, Dalibor M., Ognjanović, Miloš, Fabian, Martin, Švorc, Lubomir, Mariano, Jose F. M. L., Antić, Bratislav, "Design of titanium nitride- and wolfram carbide-doped RGO/GC electrodes for determination of gallic acid" in Analytical Biochemistry, 539 (2017):104-112,
https://doi.org/10.1016/j.ab.2017.10.018 . .

TY  - JOUR
AU  - Švorc, Lubomir
AU  - Borovska, Katarina
AU  - Cinkova, Kristina
AU  - Stanković, Dalibor M.
AU  - Plankova, Alexandra
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7183
AB  - An innovative, rapid and simple electrochemical approach for the reliable quantification of cytostatic drug flutamide (FLU) in various matrices is herein proposed. This platform involves coupling of differential pulse (DPV) and square-wave voltammetry (SWV) with a boron-doped diamond (BDD) electrode as the working electrode and 0.1 M sulphuric acid as the supporting electrolyte. For the first time, the voltammetric profile of FLU was manifested by three irreversible and diffusion-controlled oxidation peaks at + 1.1 (P1), + 1.4 (P2) and + 1.9 V (P3). The analytical performance evaluation was assessed for all three peaks, using both pulse voltammetric techniques with the optimized operating parameters and the highest sensitivity of 1.76 nA/mu M was accomplished for P2 using DPV and 3.54 nA/mu M for P3 using SWV. The corresponding linear concentration ranges were found to be 0.99-42.9 and 4.8-35.5 mu M with the detection limits of 0.42 and 0.18 mu M, respectively. The repeatability varied, depending on the oxidation peaks of FLU, with the relative standard deviations in the range of 3.3-8.8% and 2.9-9.3% for DPV and SWV, respectively. The proposed electrochemical platform was successfully applied in the analysis of pharmaceutical formulations, spiked human urine and water samples with the significant mean recoveries. Using BDD electrode, the current work establishes an advanced, simple and rapid alternative platform to so far used toxic mercury-based electrodes and time demanding chemically modified electrodes in cytostatic sensing. Besides, BDD electrode represents a comfortable electrochemical sensor for routine analysis in pharmaceutical, clinical and environmental chemistry. (C) 2017 Elsevier Ltd. All rights reserved.
T2  - Electrochimica Acta
T1  - Advanced electrochemical platform for determination of cytostatic drug flutamide in various matrices using a boron-doped diamond electrode
VL  - 251
SP  - 621
EP  - 630
DO  - 10.1016/j.electacta.2017.08.077
ER  - 

@article{
author = "Švorc, Lubomir and Borovska, Katarina and Cinkova, Kristina and Stanković, Dalibor M. and Plankova, Alexandra",
year = "2017",
abstract = "An innovative, rapid and simple electrochemical approach for the reliable quantification of cytostatic drug flutamide (FLU) in various matrices is herein proposed. This platform involves coupling of differential pulse (DPV) and square-wave voltammetry (SWV) with a boron-doped diamond (BDD) electrode as the working electrode and 0.1 M sulphuric acid as the supporting electrolyte. For the first time, the voltammetric profile of FLU was manifested by three irreversible and diffusion-controlled oxidation peaks at + 1.1 (P1), + 1.4 (P2) and + 1.9 V (P3). The analytical performance evaluation was assessed for all three peaks, using both pulse voltammetric techniques with the optimized operating parameters and the highest sensitivity of 1.76 nA/mu M was accomplished for P2 using DPV and 3.54 nA/mu M for P3 using SWV. The corresponding linear concentration ranges were found to be 0.99-42.9 and 4.8-35.5 mu M with the detection limits of 0.42 and 0.18 mu M, respectively. The repeatability varied, depending on the oxidation peaks of FLU, with the relative standard deviations in the range of 3.3-8.8% and 2.9-9.3% for DPV and SWV, respectively. The proposed electrochemical platform was successfully applied in the analysis of pharmaceutical formulations, spiked human urine and water samples with the significant mean recoveries. Using BDD electrode, the current work establishes an advanced, simple and rapid alternative platform to so far used toxic mercury-based electrodes and time demanding chemically modified electrodes in cytostatic sensing. Besides, BDD electrode represents a comfortable electrochemical sensor for routine analysis in pharmaceutical, clinical and environmental chemistry. (C) 2017 Elsevier Ltd. All rights reserved.",
journal = "Electrochimica Acta",
title = "Advanced electrochemical platform for determination of cytostatic drug flutamide in various matrices using a boron-doped diamond electrode",
volume = "251",
pages = "621-630",
doi = "10.1016/j.electacta.2017.08.077"
}

Švorc, L., Borovska, K., Cinkova, K., Stanković, D. M.,& Plankova, A.. (2017). Advanced electrochemical platform for determination of cytostatic drug flutamide in various matrices using a boron-doped diamond electrode. in Electrochimica Acta, 251, 621-630.
https://doi.org/10.1016/j.electacta.2017.08.077

Švorc L, Borovska K, Cinkova K, Stanković DM, Plankova A. Advanced electrochemical platform for determination of cytostatic drug flutamide in various matrices using a boron-doped diamond electrode. in Electrochimica Acta. 2017;251:621-630.
doi:10.1016/j.electacta.2017.08.077 .

Švorc, Lubomir, Borovska, Katarina, Cinkova, Kristina, Stanković, Dalibor M., Plankova, Alexandra, "Advanced electrochemical platform for determination of cytostatic drug flutamide in various matrices using a boron-doped diamond electrode" in Electrochimica Acta, 251 (2017):621-630,
https://doi.org/10.1016/j.electacta.2017.08.077 . .

TY  - JOUR
AU  - Stanković, Dalibor M.
AU  - Švorc, Lubomir
AU  - Mariano, Jose F. M. L.
AU  - Ortner, Astrid
AU  - Kalcher, Kurt
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1771
AB  - Colchicine (COLC) is a natural toxic product and secondary metabolite most commonly used to treat gout. In this study, its electrochemical behavior and determination was investigated by employing modification-free boron-doped diamond electrode (BDDE). Besides, its interaction with DNA was monitored using electrochemical methods. It was found that oxidation of this compound proceeds in two steps, where first sharp and well defined oxidation peak occurs at potential of around 1.19V, and second one at around 1.37V, in Britton-Robinson buffer solution at pH7.5. Wide dynamic range from 1 to 100 mu M was obtained with a detection limit (3 sigma(intercept)/slope) of a 0.26 mu M, based on the evaluation of first oxidation peak using differential pulse voltammetry. The proposed method was also found to be suitable for monitoring interaction of this drug with DNA as important segment for medical use. Concerning the validation, the analytical procedure shows excellent selectivity and sensitivity toward COLC detection and after method development it was successfully used for its quantification in pharmaceutical preparation and human serum sample, with satisfactory recovery. Obviously, this approach can be promising replacement for time-consuming and expensive separation methods.
T2  - Electroanalysis
T1  - Electrochemical Determination of Natural Drug Colchicine in Pharmaceuticals and Human Serum Sample and its Interaction with DNA
VL  - 29
IS  - 10
SP  - 2276
EP  - 2281
DO  - 10.1002/elan.201700233
ER  - 

@article{
author = "Stanković, Dalibor M. and Švorc, Lubomir and Mariano, Jose F. M. L. and Ortner, Astrid and Kalcher, Kurt",
year = "2017",
abstract = "Colchicine (COLC) is a natural toxic product and secondary metabolite most commonly used to treat gout. In this study, its electrochemical behavior and determination was investigated by employing modification-free boron-doped diamond electrode (BDDE). Besides, its interaction with DNA was monitored using electrochemical methods. It was found that oxidation of this compound proceeds in two steps, where first sharp and well defined oxidation peak occurs at potential of around 1.19V, and second one at around 1.37V, in Britton-Robinson buffer solution at pH7.5. Wide dynamic range from 1 to 100 mu M was obtained with a detection limit (3 sigma(intercept)/slope) of a 0.26 mu M, based on the evaluation of first oxidation peak using differential pulse voltammetry. The proposed method was also found to be suitable for monitoring interaction of this drug with DNA as important segment for medical use. Concerning the validation, the analytical procedure shows excellent selectivity and sensitivity toward COLC detection and after method development it was successfully used for its quantification in pharmaceutical preparation and human serum sample, with satisfactory recovery. Obviously, this approach can be promising replacement for time-consuming and expensive separation methods.",
journal = "Electroanalysis",
title = "Electrochemical Determination of Natural Drug Colchicine in Pharmaceuticals and Human Serum Sample and its Interaction with DNA",
volume = "29",
number = "10",
pages = "2276-2281",
doi = "10.1002/elan.201700233"
}

Stanković, D. M., Švorc, L., Mariano, J. F. M. L., Ortner, A.,& Kalcher, K.. (2017). Electrochemical Determination of Natural Drug Colchicine in Pharmaceuticals and Human Serum Sample and its Interaction with DNA. in Electroanalysis, 29(10), 2276-2281.
https://doi.org/10.1002/elan.201700233

Stanković DM, Švorc L, Mariano JFML, Ortner A, Kalcher K. Electrochemical Determination of Natural Drug Colchicine in Pharmaceuticals and Human Serum Sample and its Interaction with DNA. in Electroanalysis. 2017;29(10):2276-2281.
doi:10.1002/elan.201700233 .

Stanković, Dalibor M., Švorc, Lubomir, Mariano, Jose F. M. L., Ortner, Astrid, Kalcher, Kurt, "Electrochemical Determination of Natural Drug Colchicine in Pharmaceuticals and Human Serum Sample and its Interaction with DNA" in Electroanalysis, 29, no. 10 (2017):2276-2281,
https://doi.org/10.1002/elan.201700233 . .

TY  - JOUR
AU  - Samiec, Petr
AU  - Švorc, Lubomir
AU  - Stanković, Dalibor M.
AU  - Vojs, Marian
AU  - Marton, Marian
AU  - Navratilova, Zuzana
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1504
AB  - The boron-doped diamond electrodes (BDDEs) with different dopant levels were applied as advanced, mercury-free and modification-free electroanalytical platforms for simple and reliable quantification of benzodiazepines, bromazepam (BZ) and alprazolam (ALZ). Cyclic voltammetric measurements revealed that the electrode reactions of both analytes were manifested by one irreversible and diffusion-controlled reduction peak at -1.10V in Britton-Robinson buffer of pH 11 for BZ using lab-made BDDE with 1000 ppm B/C ratio and -0.84V in BR buffer of pH 5 for ALZ using commercial BDDE with 1000 ppm B/C ratio. Differential pulse voltammetry was used for construction of calibration curves for BZ and ALZ, respectively, with the analytical parameters as follows: the linear dynamic ranges of 1 x 10(-6)-1 x 10(-4) and 8 x 10(-7)-1 x 10(-4) mol/L, the detection limit of 3.1 x 10(-7) and 6.4 x 10(-7) mol/L and the excellent repeatability with the relative standard deviation below 3% for both drugs. The developed methods were applied to analysis of the pharmaceutical tablets with the recoveries from 97.33 to 100.85% for BZ and from 94.14 to 101.32% for ALZ. The usage of BDDEs as advanced electrochemical sensors in drug analysis represents a facile and effective analytical approach which may replace mercury-based sensors and chemically modified electrodes in previous benzodiazepines sensing. (C) 2017 Elsevier B.V. All rights reserved.
T2  - Sensors and Actuators B: Chemical
T1  - Mercury-free and modification-free electroanalytical approach towards bromazepam and alprazolam sensing: A facile and efficient assay for their quantification in pharmaceuticals using boron-doped diamond electrodes
VL  - 245
SP  - 963
EP  - 971
DO  - 10.1016/j.snb.2017.02.023
ER  - 

@article{
author = "Samiec, Petr and Švorc, Lubomir and Stanković, Dalibor M. and Vojs, Marian and Marton, Marian and Navratilova, Zuzana",
year = "2017",
abstract = "The boron-doped diamond electrodes (BDDEs) with different dopant levels were applied as advanced, mercury-free and modification-free electroanalytical platforms for simple and reliable quantification of benzodiazepines, bromazepam (BZ) and alprazolam (ALZ). Cyclic voltammetric measurements revealed that the electrode reactions of both analytes were manifested by one irreversible and diffusion-controlled reduction peak at -1.10V in Britton-Robinson buffer of pH 11 for BZ using lab-made BDDE with 1000 ppm B/C ratio and -0.84V in BR buffer of pH 5 for ALZ using commercial BDDE with 1000 ppm B/C ratio. Differential pulse voltammetry was used for construction of calibration curves for BZ and ALZ, respectively, with the analytical parameters as follows: the linear dynamic ranges of 1 x 10(-6)-1 x 10(-4) and 8 x 10(-7)-1 x 10(-4) mol/L, the detection limit of 3.1 x 10(-7) and 6.4 x 10(-7) mol/L and the excellent repeatability with the relative standard deviation below 3% for both drugs. The developed methods were applied to analysis of the pharmaceutical tablets with the recoveries from 97.33 to 100.85% for BZ and from 94.14 to 101.32% for ALZ. The usage of BDDEs as advanced electrochemical sensors in drug analysis represents a facile and effective analytical approach which may replace mercury-based sensors and chemically modified electrodes in previous benzodiazepines sensing. (C) 2017 Elsevier B.V. All rights reserved.",
journal = "Sensors and Actuators B: Chemical",
title = "Mercury-free and modification-free electroanalytical approach towards bromazepam and alprazolam sensing: A facile and efficient assay for their quantification in pharmaceuticals using boron-doped diamond electrodes",
volume = "245",
pages = "963-971",
doi = "10.1016/j.snb.2017.02.023"
}

Samiec, P., Švorc, L., Stanković, D. M., Vojs, M., Marton, M.,& Navratilova, Z.. (2017). Mercury-free and modification-free electroanalytical approach towards bromazepam and alprazolam sensing: A facile and efficient assay for their quantification in pharmaceuticals using boron-doped diamond electrodes. in Sensors and Actuators B: Chemical, 245, 963-971.
https://doi.org/10.1016/j.snb.2017.02.023

Samiec P, Švorc L, Stanković DM, Vojs M, Marton M, Navratilova Z. Mercury-free and modification-free electroanalytical approach towards bromazepam and alprazolam sensing: A facile and efficient assay for their quantification in pharmaceuticals using boron-doped diamond electrodes. in Sensors and Actuators B: Chemical. 2017;245:963-971.
doi:10.1016/j.snb.2017.02.023 .

Samiec, Petr, Švorc, Lubomir, Stanković, Dalibor M., Vojs, Marian, Marton, Marian, Navratilova, Zuzana, "Mercury-free and modification-free electroanalytical approach towards bromazepam and alprazolam sensing: A facile and efficient assay for their quantification in pharmaceuticals using boron-doped diamond electrodes" in Sensors and Actuators B: Chemical, 245 (2017):963-971,
https://doi.org/10.1016/j.snb.2017.02.023 . .