TY  - JOUR
AU  - Spirou, Spiridon
AU  - Costa Lima, Sofia
AU  - Bouziotis, Penelope
AU  - Vranješ-Đurić, Sanja
AU  - Efthimiadou, Eleni
AU  - Laurenzana, Anna
AU  - Barbosa, Ana
AU  - Garcia-Alonso, Ignacio
AU  - Jones, Carlton
AU  - Janković, Drina
AU  - Gobbo, Oliviero
PY  - 2018
UR  - http://www.mdpi.com/2079-4991/8/5/306
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7707
AB  - Magnetic nanoparticle (MNP)-mediated hyperthermia (MH) coupled with radiation therapy (RT) is a novel approach that has the potential to overcome various practical difficulties encountered in cancer treatment. In this work, we present recommendations for the in vitro and in vivo testing and application of the two treatment techniques. These recommendations were developed by the members of Working Group 3 of COST Action TD 1402: Multifunctional Nanoparticles for Magnetic Hyperthermia and Indirect Radiation Therapy (“Radiomag”). The purpose of the recommendations is not to provide definitive answers and directions but, rather, to outline those tests and considerations that a researcher must address in order to perform in vitro and in vivo studies. The recommendations are divided into 5 parts: (a) in vitro evaluation of MNPs; (b) in vitro evaluation of MNP-cell interactions; (c) in vivo evaluation of the MNPs; (d) MH combined with RT; and (e) pharmacokinetic studies of MNPs. Synthesis and characterization of the MNPs, as well as RT protocols, are beyond the scope of this work.
T2  - Nanomaterials
T1  - Recommendations for In Vitro and In Vivo Testing of Magnetic Nanoparticle Hyperthermia Combined with Radiation Therapy
VL  - 8
IS  - 5
SP  - 306
DO  - 10.3390/nano8050306
ER  - 

@article{
author = "Spirou, Spiridon and Costa Lima, Sofia and Bouziotis, Penelope and Vranješ-Đurić, Sanja and Efthimiadou, Eleni and Laurenzana, Anna and Barbosa, Ana and Garcia-Alonso, Ignacio and Jones, Carlton and Janković, Drina and Gobbo, Oliviero",
year = "2018",
abstract = "Magnetic nanoparticle (MNP)-mediated hyperthermia (MH) coupled with radiation therapy (RT) is a novel approach that has the potential to overcome various practical difficulties encountered in cancer treatment. In this work, we present recommendations for the in vitro and in vivo testing and application of the two treatment techniques. These recommendations were developed by the members of Working Group 3 of COST Action TD 1402: Multifunctional Nanoparticles for Magnetic Hyperthermia and Indirect Radiation Therapy (“Radiomag”). The purpose of the recommendations is not to provide definitive answers and directions but, rather, to outline those tests and considerations that a researcher must address in order to perform in vitro and in vivo studies. The recommendations are divided into 5 parts: (a) in vitro evaluation of MNPs; (b) in vitro evaluation of MNP-cell interactions; (c) in vivo evaluation of the MNPs; (d) MH combined with RT; and (e) pharmacokinetic studies of MNPs. Synthesis and characterization of the MNPs, as well as RT protocols, are beyond the scope of this work.",
journal = "Nanomaterials",
title = "Recommendations for In Vitro and In Vivo Testing of Magnetic Nanoparticle Hyperthermia Combined with Radiation Therapy",
volume = "8",
number = "5",
pages = "306",
doi = "10.3390/nano8050306"
}

Spirou, S., Costa Lima, S., Bouziotis, P., Vranješ-Đurić, S., Efthimiadou, E., Laurenzana, A., Barbosa, A., Garcia-Alonso, I., Jones, C., Janković, D.,& Gobbo, O.. (2018). Recommendations for In Vitro and In Vivo Testing of Magnetic Nanoparticle Hyperthermia Combined with Radiation Therapy. in Nanomaterials, 8(5), 306.
https://doi.org/10.3390/nano8050306

Spirou S, Costa Lima S, Bouziotis P, Vranješ-Đurić S, Efthimiadou E, Laurenzana A, Barbosa A, Garcia-Alonso I, Jones C, Janković D, Gobbo O. Recommendations for In Vitro and In Vivo Testing of Magnetic Nanoparticle Hyperthermia Combined with Radiation Therapy. in Nanomaterials. 2018;8(5):306.
doi:10.3390/nano8050306 .

Spirou, Spiridon, Costa Lima, Sofia, Bouziotis, Penelope, Vranješ-Đurić, Sanja, Efthimiadou, Eleni, Laurenzana, Anna, Barbosa, Ana, Garcia-Alonso, Ignacio, Jones, Carlton, Janković, Drina, Gobbo, Oliviero, "Recommendations for In Vitro and In Vivo Testing of Magnetic Nanoparticle Hyperthermia Combined with Radiation Therapy" in Nanomaterials, 8, no. 5 (2018):306,
https://doi.org/10.3390/nano8050306 . .