Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200017 (University of Belgrade, Institute of Nuclear Sciences 'Vinča', Belgrade-Vinča)

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Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200017 (University of Belgrade, Institute of Nuclear Sciences 'Vinča', Belgrade-Vinča) (en)
Ministarstvo prosvete, nauke i tehnološkog razvoja Republike Srbije, Ugovor br. 451-03-68/2020-14/200017 (Univerzitet u Beogradu, Institut za nuklearne nauke Vinča, Beograd-Vinča) (sr_RS)
Министарство просвете, науке и технолошког развоја Републике Србије, Уговор бр. 451-03-68/2020-14/200017 (Универзитет у Београду, Институт за нуклеарне науке Винча, Београд-Винча) (sr)
Authors

Publications

Meta-signature guided investigation of miRNA candidates as potential biomarkers of oral cancer

Stojković, Goran; Jovanović, Ivan; Dimitrijević, Milovan; Jovanović, Jasmina; Tomanović, Nada; Stanković, Aleksandra; Arsović, Nenad; Boričić, Ivan; Zeljić, Katarina

TY  - JOUR
AU  - Stojković, Goran
AU  - Jovanović, Ivan
AU  - Dimitrijević, Milovan
AU  - Jovanović, Jasmina
AU  - Tomanović, Nada
AU  - Stanković, Aleksandra
AU  - Arsović, Nenad
AU  - Boričić, Ivan
AU  - Zeljić, Katarina
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10217
AB  - Objectives This study aimed to experimentally validate dysregulated expression of miRNA candidates selected through updated meta-analysis of most commonly deregulated miRNAs in oral cancer and to explore their diagnostic and prognostic potential. Materials and methods Five miRNAs (miR-31-3p, miR-135b-5p, miR-18a-5p, miR-30a-5p and miR-139-5p) from updated meta-signature were selected for validation by qRT-PCR method in 35 oral cancer clinical specimens and adjacent non-cancerous tissue. Results Updated meta-analysis has identified 13 most commonly deregulated miRNAs in oral cancer. Seven miRNAs were consistently up-regulated (miR-21-5p, miR-31-3p, miR-135b-5p, miR-31-5p, miR-424-5p, miR-18a-5p and miR-21-3p), while five were down-regulated (miR-139-5p, miR-30a-3p, miR-375-3p, miR-376c-3p and miR-30a-5p). Increased expression of miR-31-3p and miR-135b-5p, and decreased expression of miR-139-5p and miR-30a-5p were confirmed in oral cancer compared to adjacent non-cancerous tissue. A three miRNAs combination (miR-31-3p, miR-139-5p and miR-30a-5p) gave the most promising diagnostic potential for discriminating oral cancer from non-cancerous tissue (AUC: 0.780 [95% CI: 0.673–0.886], p < 0.0005, sensitivity 94.3%, specificity 51.4%). High expression of miR-135b-5p, miR-18a-5p and miR-30a-5p was associated with poor survival (p = 0.003, p = 0.048, p = 0.016 respectively). Conclusion miR-31-3p, miR-139-5p and miR-30a-5p panel was confirmed as a potential diagnostic biomarker when distinguishing oral cancer from non-cancerous tissue. miR-135b-5p, miR-18a-5p and miR-30a-5p might serve as potential biomarkers of poor survival of oral cancer patients.
T2  - Oral Diseases
T1  - Meta-signature guided investigation of miRNA candidates as potential biomarkers of oral cancer
DO  - 10.1111/odi.14185
ER  - 
@article{
author = "Stojković, Goran and Jovanović, Ivan and Dimitrijević, Milovan and Jovanović, Jasmina and Tomanović, Nada and Stanković, Aleksandra and Arsović, Nenad and Boričić, Ivan and Zeljić, Katarina",
abstract = "Objectives This study aimed to experimentally validate dysregulated expression of miRNA candidates selected through updated meta-analysis of most commonly deregulated miRNAs in oral cancer and to explore their diagnostic and prognostic potential. Materials and methods Five miRNAs (miR-31-3p, miR-135b-5p, miR-18a-5p, miR-30a-5p and miR-139-5p) from updated meta-signature were selected for validation by qRT-PCR method in 35 oral cancer clinical specimens and adjacent non-cancerous tissue. Results Updated meta-analysis has identified 13 most commonly deregulated miRNAs in oral cancer. Seven miRNAs were consistently up-regulated (miR-21-5p, miR-31-3p, miR-135b-5p, miR-31-5p, miR-424-5p, miR-18a-5p and miR-21-3p), while five were down-regulated (miR-139-5p, miR-30a-3p, miR-375-3p, miR-376c-3p and miR-30a-5p). Increased expression of miR-31-3p and miR-135b-5p, and decreased expression of miR-139-5p and miR-30a-5p were confirmed in oral cancer compared to adjacent non-cancerous tissue. A three miRNAs combination (miR-31-3p, miR-139-5p and miR-30a-5p) gave the most promising diagnostic potential for discriminating oral cancer from non-cancerous tissue (AUC: 0.780 [95% CI: 0.673–0.886], p < 0.0005, sensitivity 94.3%, specificity 51.4%). High expression of miR-135b-5p, miR-18a-5p and miR-30a-5p was associated with poor survival (p = 0.003, p = 0.048, p = 0.016 respectively). Conclusion miR-31-3p, miR-139-5p and miR-30a-5p panel was confirmed as a potential diagnostic biomarker when distinguishing oral cancer from non-cancerous tissue. miR-135b-5p, miR-18a-5p and miR-30a-5p might serve as potential biomarkers of poor survival of oral cancer patients.",
journal = "Oral Diseases",
title = "Meta-signature guided investigation of miRNA candidates as potential biomarkers of oral cancer",
doi = "10.1111/odi.14185"
}
Stojković, G., Jovanović, I., Dimitrijević, M., Jovanović, J., Tomanović, N., Stanković, A., Arsović, N., Boričić, I.,& Zeljić, K..Meta-signature guided investigation of miRNA candidates as potential biomarkers of oral cancer. in Oral Diseases.
https://doi.org/10.1111/odi.14185
Stojković G, Jovanović I, Dimitrijević M, Jovanović J, Tomanović N, Stanković A, Arsović N, Boričić I, Zeljić K. Meta-signature guided investigation of miRNA candidates as potential biomarkers of oral cancer. in Oral Diseases..
doi:10.1111/odi.14185 .
Stojković, Goran, Jovanović, Ivan, Dimitrijević, Milovan, Jovanović, Jasmina, Tomanović, Nada, Stanković, Aleksandra, Arsović, Nenad, Boričić, Ivan, Zeljić, Katarina, "Meta-signature guided investigation of miRNA candidates as potential biomarkers of oral cancer" in Oral Diseases,
https://doi.org/10.1111/odi.14185 . .

Non-coding RNA and cholesteatoma

Jovanović, Ivan G.; Živković, Maja; Ješić, Snežana; Stanković, Aleksandra

TY  - JOUR
AU  - Jovanović, Ivan G.
AU  - Živković, Maja
AU  - Ješić, Snežana
AU  - Stanković, Aleksandra
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10115
AB  - Objective Cholesteatoma is a challenging chronic pathology of the middle ear for which pharmacologic therapies have not been developed yet. Cholesteatoma occurrence depends on the interplay between genetic and environmental factors while master regulators orchestrating disease progression are still unknown. Therefore, in this review, we will discuss the diagnostic and therapeutic potential of non-coding RNAs (ncRNA) as a new class of regulatory molecules. Methods We have comprehensively reviewed all articles investigating ncRNAs, specifically micro RNAs (miRNAs) and long ncRNAs (lncRNA/circRNA) in cholesteatoma tissue. Results Candidate miRNA approaches indicated that miR-21 and let-7a are the major miRNAs involved in cholesteatoma growth, migration, proliferation, bone destruction, and apoptosis. Regulatory potential for the same biological processes was also observed for miR-203a. The NF-kB/miR-802/PTEN regulatory network was in relation to observed miR-21 activity in cholesteatoma as well. High throughput approaches revealed additional ncRNAs implicated in cholesteatoma pathology. Competitive endogenous RNA (ceRNA) analysis highlighted lncRNA/circRNA that could be “endogenous sponge” for miR-21 and let-7a based on the hypothesis that RNA transcripts can communicate with and regulate each other by using shared miRNA response elements. Conclusion In this review, we summarize the discoveries and role of ncRNA in major pathways in cholesteatoma and highlight the potential of miRNA-based therapeutics in the treatment of cholesteatoma. Level of Evidence: NA.
T2  - Laryngoscope Investigative Otolaryngology
T2  - Laryngoscope Investigative Otolaryngology
T1  - Non-coding RNA and cholesteatoma
DO  - 10.1002/lio2.728
ER  - 
@article{
author = "Jovanović, Ivan G. and Živković, Maja and Ješić, Snežana and Stanković, Aleksandra",
abstract = "Objective Cholesteatoma is a challenging chronic pathology of the middle ear for which pharmacologic therapies have not been developed yet. Cholesteatoma occurrence depends on the interplay between genetic and environmental factors while master regulators orchestrating disease progression are still unknown. Therefore, in this review, we will discuss the diagnostic and therapeutic potential of non-coding RNAs (ncRNA) as a new class of regulatory molecules. Methods We have comprehensively reviewed all articles investigating ncRNAs, specifically micro RNAs (miRNAs) and long ncRNAs (lncRNA/circRNA) in cholesteatoma tissue. Results Candidate miRNA approaches indicated that miR-21 and let-7a are the major miRNAs involved in cholesteatoma growth, migration, proliferation, bone destruction, and apoptosis. Regulatory potential for the same biological processes was also observed for miR-203a. The NF-kB/miR-802/PTEN regulatory network was in relation to observed miR-21 activity in cholesteatoma as well. High throughput approaches revealed additional ncRNAs implicated in cholesteatoma pathology. Competitive endogenous RNA (ceRNA) analysis highlighted lncRNA/circRNA that could be “endogenous sponge” for miR-21 and let-7a based on the hypothesis that RNA transcripts can communicate with and regulate each other by using shared miRNA response elements. Conclusion In this review, we summarize the discoveries and role of ncRNA in major pathways in cholesteatoma and highlight the potential of miRNA-based therapeutics in the treatment of cholesteatoma. Level of Evidence: NA.",
journal = "Laryngoscope Investigative Otolaryngology, Laryngoscope Investigative Otolaryngology",
title = "Non-coding RNA and cholesteatoma",
doi = "10.1002/lio2.728"
}
Jovanović, I. G., Živković, M., Ješić, S.,& Stanković, A..Non-coding RNA and cholesteatoma. in Laryngoscope Investigative Otolaryngology.
https://doi.org/10.1002/lio2.728
Jovanović IG, Živković M, Ješić S, Stanković A. Non-coding RNA and cholesteatoma. in Laryngoscope Investigative Otolaryngology..
doi:10.1002/lio2.728 .
Jovanović, Ivan G., Živković, Maja, Ješić, Snežana, Stanković, Aleksandra, "Non-coding RNA and cholesteatoma" in Laryngoscope Investigative Otolaryngology,
https://doi.org/10.1002/lio2.728 . .
1

Use neural network in photoacoustic measurement of thermoelastic properties of aluminum foil

Đorđević, Кatarina Lj.; Galović, Slobodanka; Popović, Marica N.; Nešić, Mioljub V.; Stanimirović, Ivanka P.; Stanimirović, Zdravko I.; Markushev, Dragan D.

(2022)

TY  - JOUR
AU  - Đorđević, Кatarina Lj.
AU  - Galović, Slobodanka
AU  - Popović, Marica N.
AU  - Nešić, Mioljub V.
AU  - Stanimirović, Ivanka P.
AU  - Stanimirović, Zdravko I.
AU  - Markushev, Dragan D.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10364
AB  - The objective of this paper is to present methodology of the precise and reliable determination of thermal diffusivity and linear coefficient of thermal expansion of the photoacoustic signal recorded (obtained) using open photoacoustic cell where thickness of the sample served as a control parameter. The methodology was based on the application of neural networks that were trained on numerical experiments and optimized by adding Gaussian noise to the training base that corresponded in percentage to maximum measurement uncertainty. By comparing the predictions of the neural network with theoretical fitting curve for experimental results for the aluminum sample that was 197 μm thick, it was shown that the proposed methodology achieves high precision in the determination of thermoelastic and geometrical properties of the sample.
T2  - Measurement
T1  - Use neural network in photoacoustic measurement of thermoelastic properties of aluminum foil
SP  - 111537
DO  - 10.1016/j.measurement.2022.111537
ER  - 
@article{
author = "Đorđević, Кatarina Lj. and Galović, Slobodanka and Popović, Marica N. and Nešić, Mioljub V. and Stanimirović, Ivanka P. and Stanimirović, Zdravko I. and Markushev, Dragan D.",
year = "2022",
abstract = "The objective of this paper is to present methodology of the precise and reliable determination of thermal diffusivity and linear coefficient of thermal expansion of the photoacoustic signal recorded (obtained) using open photoacoustic cell where thickness of the sample served as a control parameter. The methodology was based on the application of neural networks that were trained on numerical experiments and optimized by adding Gaussian noise to the training base that corresponded in percentage to maximum measurement uncertainty. By comparing the predictions of the neural network with theoretical fitting curve for experimental results for the aluminum sample that was 197 μm thick, it was shown that the proposed methodology achieves high precision in the determination of thermoelastic and geometrical properties of the sample.",
journal = "Measurement",
title = "Use neural network in photoacoustic measurement of thermoelastic properties of aluminum foil",
pages = "111537",
doi = "10.1016/j.measurement.2022.111537"
}
Đorđević, К. Lj., Galović, S., Popović, M. N., Nešić, M. V., Stanimirović, I. P., Stanimirović, Z. I.,& Markushev, D. D.. (2022). Use neural network in photoacoustic measurement of thermoelastic properties of aluminum foil. in Measurement, 111537.
https://doi.org/10.1016/j.measurement.2022.111537
Đorđević КL, Galović S, Popović MN, Nešić MV, Stanimirović IP, Stanimirović ZI, Markushev DD. Use neural network in photoacoustic measurement of thermoelastic properties of aluminum foil. in Measurement. 2022;:111537.
doi:10.1016/j.measurement.2022.111537 .
Đorđević, Кatarina Lj., Galović, Slobodanka, Popović, Marica N., Nešić, Mioljub V., Stanimirović, Ivanka P., Stanimirović, Zdravko I., Markushev, Dragan D., "Use neural network in photoacoustic measurement of thermoelastic properties of aluminum foil" in Measurement (2022):111537,
https://doi.org/10.1016/j.measurement.2022.111537 . .

Influence of data scaling and normalization on overall neural network performances in photoacoustics

Đorđević, Katarina Lj.; Jordović-Pavlović, Miroslava I.; Ćojbašić, Ž. M.; Galović, Slobodanka; Popović, Marica N.; Nešić, Mioljub V.; Markushev, Dragan D.

(2022)

TY  - JOUR
AU  - Đorđević, Katarina Lj.
AU  - Jordović-Pavlović, Miroslava I.
AU  - Ćojbašić, Ž. M.
AU  - Galović, Slobodanka
AU  - Popović, Marica N.
AU  - Nešić, Mioljub V.
AU  - Markushev, Dragan D.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10359
AB  - In this paper, the influence of the input and output data scaling and normalization on the neural network overall performances is investigated aimed at inverse problem-solving in photoacoustics of semiconductors. The logarithmic scaling of the photoacoustic signal amplitudes as input data and numerical scaling of the sample thermal parameters as output data are presented as useful tools trying to reach maximal network precision. Max and min–max normalizations to the input data are presented to change their numerical values in the dataset to common scales, without distorting differences. It was demonstrated in theory that the largest network prediction error of all targeted parameters is obtained by a network with non-scaled output data. Also, it was found out that the best network prediction was achieved with min–max normalization of the input data and network predicted output data scale within the range of [1–10]. Network training and prediction performances analyzed with experimental input data show that the benefits and improvements of input and output scaling and normalization are not guaranteed but are strongly dependent on a specific problem to be solved.
T2  - Optical and Quantum Electronics
T1  - Influence of data scaling and normalization on overall neural network performances in photoacoustics
VL  - 54
IS  - 8
SP  - 501
DO  - 10.1007/s11082-022-03799-1
ER  - 
@article{
author = "Đorđević, Katarina Lj. and Jordović-Pavlović, Miroslava I. and Ćojbašić, Ž. M. and Galović, Slobodanka and Popović, Marica N. and Nešić, Mioljub V. and Markushev, Dragan D.",
year = "2022",
abstract = "In this paper, the influence of the input and output data scaling and normalization on the neural network overall performances is investigated aimed at inverse problem-solving in photoacoustics of semiconductors. The logarithmic scaling of the photoacoustic signal amplitudes as input data and numerical scaling of the sample thermal parameters as output data are presented as useful tools trying to reach maximal network precision. Max and min–max normalizations to the input data are presented to change their numerical values in the dataset to common scales, without distorting differences. It was demonstrated in theory that the largest network prediction error of all targeted parameters is obtained by a network with non-scaled output data. Also, it was found out that the best network prediction was achieved with min–max normalization of the input data and network predicted output data scale within the range of [1–10]. Network training and prediction performances analyzed with experimental input data show that the benefits and improvements of input and output scaling and normalization are not guaranteed but are strongly dependent on a specific problem to be solved.",
journal = "Optical and Quantum Electronics",
title = "Influence of data scaling and normalization on overall neural network performances in photoacoustics",
volume = "54",
number = "8",
pages = "501",
doi = "10.1007/s11082-022-03799-1"
}
Đorđević, K. Lj., Jordović-Pavlović, M. I., Ćojbašić, Ž. M., Galović, S., Popović, M. N., Nešić, M. V.,& Markushev, D. D.. (2022). Influence of data scaling and normalization on overall neural network performances in photoacoustics. in Optical and Quantum Electronics, 54(8), 501.
https://doi.org/10.1007/s11082-022-03799-1
Đorđević KL, Jordović-Pavlović MI, Ćojbašić ŽM, Galović S, Popović MN, Nešić MV, Markushev DD. Influence of data scaling and normalization on overall neural network performances in photoacoustics. in Optical and Quantum Electronics. 2022;54(8):501.
doi:10.1007/s11082-022-03799-1 .
Đorđević, Katarina Lj., Jordović-Pavlović, Miroslava I., Ćojbašić, Ž. M., Galović, Slobodanka, Popović, Marica N., Nešić, Mioljub V., Markushev, Dragan D., "Influence of data scaling and normalization on overall neural network performances in photoacoustics" in Optical and Quantum Electronics, 54, no. 8 (2022):501,
https://doi.org/10.1007/s11082-022-03799-1 . .

Novel approach for strontium preconcentration from seawater and rapid determination of 89,90Sr in emergency situations

Coha, Ivana; Smičiklas, Ivana; Tucaković, Ivana; Jović, Mihajlo; Šljivić-Ivanović, Marija; Grahek, Željko

(2022)

TY  - JOUR
AU  - Coha, Ivana
AU  - Smičiklas, Ivana
AU  - Tucaković, Ivana
AU  - Jović, Mihajlo
AU  - Šljivić-Ivanović, Marija
AU  - Grahek, Željko
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10357
AB  - A novel approach for rapid 89,90Sr determination in seawater samples is developed. For the first time in the radioanalytical application, the features of the synthetic zeolite Z4A and a highly selective material for Sr separation were synergically employed. Seawater composition significantly reduces Sr yield on highly selective solid-phase extraction materials, making the preconcentration step essentially important but laborious and time-consuming. To address this issue, the ability of zeolite 4A to concentrate the Sr from the seawater matrix was employed. With the proposed method, two important goals were achieved: (i) simple preconcentration of Sr that can be conducted directly at the sampling site, enabling a rapid procedure for 89,90Sr determination in emergencies, and (ii) high and stable Sr recoveries (89 ± 4%) necessary for lowering detection limits. Strontium is effectively separated from 1 L of seawater in less than 1.5 h, which is especially important in emergency situations, such as the Fukushima Daiichi Nuclear Power Plant accident. Minimum detectable activities achieved for 89Sr:90Sr activity ratio ∼10:1 were 0.74 Bq/L for 89Sr, and 1.47 Bq/L for 90Sr, detected by Cherenkov counting, 36–38 h after separation, and 30 min counting time.
T2  - Talanta
T1  - Novel approach for strontium preconcentration from seawater and rapid determination of 89,90Sr in emergency situations
VL  - 250
SP  - 123722
DO  - 10.1016/j.talanta.2022.123722
ER  - 
@article{
author = "Coha, Ivana and Smičiklas, Ivana and Tucaković, Ivana and Jović, Mihajlo and Šljivić-Ivanović, Marija and Grahek, Željko",
year = "2022",
abstract = "A novel approach for rapid 89,90Sr determination in seawater samples is developed. For the first time in the radioanalytical application, the features of the synthetic zeolite Z4A and a highly selective material for Sr separation were synergically employed. Seawater composition significantly reduces Sr yield on highly selective solid-phase extraction materials, making the preconcentration step essentially important but laborious and time-consuming. To address this issue, the ability of zeolite 4A to concentrate the Sr from the seawater matrix was employed. With the proposed method, two important goals were achieved: (i) simple preconcentration of Sr that can be conducted directly at the sampling site, enabling a rapid procedure for 89,90Sr determination in emergencies, and (ii) high and stable Sr recoveries (89 ± 4%) necessary for lowering detection limits. Strontium is effectively separated from 1 L of seawater in less than 1.5 h, which is especially important in emergency situations, such as the Fukushima Daiichi Nuclear Power Plant accident. Minimum detectable activities achieved for 89Sr:90Sr activity ratio ∼10:1 were 0.74 Bq/L for 89Sr, and 1.47 Bq/L for 90Sr, detected by Cherenkov counting, 36–38 h after separation, and 30 min counting time.",
journal = "Talanta",
title = "Novel approach for strontium preconcentration from seawater and rapid determination of 89,90Sr in emergency situations",
volume = "250",
pages = "123722",
doi = "10.1016/j.talanta.2022.123722"
}
Coha, I., Smičiklas, I., Tucaković, I., Jović, M., Šljivić-Ivanović, M.,& Grahek, Ž.. (2022). Novel approach for strontium preconcentration from seawater and rapid determination of 89,90Sr in emergency situations. in Talanta, 250, 123722.
https://doi.org/10.1016/j.talanta.2022.123722
Coha I, Smičiklas I, Tucaković I, Jović M, Šljivić-Ivanović M, Grahek Ž. Novel approach for strontium preconcentration from seawater and rapid determination of 89,90Sr in emergency situations. in Talanta. 2022;250:123722.
doi:10.1016/j.talanta.2022.123722 .
Coha, Ivana, Smičiklas, Ivana, Tucaković, Ivana, Jović, Mihajlo, Šljivić-Ivanović, Marija, Grahek, Željko, "Novel approach for strontium preconcentration from seawater and rapid determination of 89,90Sr in emergency situations" in Talanta, 250 (2022):123722,
https://doi.org/10.1016/j.talanta.2022.123722 . .

Obesity-related prepartal insulin resistance in dairy cows is associated with increased lipin 1 and decreased FATP 1 expression in skeletal muscle

Prodanović, Radiša; Kirovski, Danijela; Vujanac, Ivan; Đorđević, Ana; Romić, Snježana Đ.; Pantelić, Marija; Korićanac, Goran

(2022)

TY  - JOUR
AU  - Prodanović, Radiša
AU  - Kirovski, Danijela
AU  - Vujanac, Ivan
AU  - Đorđević, Ana
AU  - Romić, Snježana Đ.
AU  - Pantelić, Marija
AU  - Korićanac, Goran
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10356
AB  - A number of alterations have been identified in lipid metabolism within adipose tissue and liver in obesity. Less is known about the capacity of skeletal muscle for the metabolism of fatty acids in obesity-related insulin resistance, though it is evident that dry cow muscles may contain increased triglyceride content. The current study was therefore undertaken to evaluate the skeletal muscle expression of proteins of the fatty acid metabolism in dry cows with different body condition scores (BCS). Sixteen Holstein-Friesian close-up cows were divided into 2 equal groups based on their BCS as optimal (3.25 ≤ BCS ≤ 3.5) and high (4.0 ≤ BCS ≤ 4.25). Blood samples collection and skeletal muscle biopsies were carried out at day 10 before calving. Blood serum was assayed for concentration of resistin using a bovine specific ELISA. Protein expression of insulin receptor beta subunit (IRβ), glucose transporter 4 (GLUT4), fatty acid translocase (FAT/CD36), fatty acid transporter 1 (FATP1), carnitine palmitoyltransferase 1 (CPT1), AMP-acitvated protein kinase (AMPK) and lipin 1 were analyzed in semitendinosus muscle by immunoblot. Resistin differed non-significantly between high-BCS and optimal-BCS cows. Insulin-resistant lipid metabolism in obese cows was paralleled with increased skeletal muscle expression of lipin 1 and GLUT4, and decreased expression of IRβ and FATP1. These data suggest that in obesity-related insulin resistance, metabolic capacity in dry cow skeletal muscles appears to be organized towards the synthesis of signaling intermediates rather than fatty acids oxidation and that altered fatty acid uptake does not contribute to this disposition.
T2  - Research in Veterinary Science
T1  - Obesity-related prepartal insulin resistance in dairy cows is associated with increased lipin 1 and decreased FATP 1 expression in skeletal muscle
VL  - 150
SP  - 189
EP  - 194
DO  - 10.1016/j.rvsc.2022.04.012
ER  - 
@article{
author = "Prodanović, Radiša and Kirovski, Danijela and Vujanac, Ivan and Đorđević, Ana and Romić, Snježana Đ. and Pantelić, Marija and Korićanac, Goran",
year = "2022",
abstract = "A number of alterations have been identified in lipid metabolism within adipose tissue and liver in obesity. Less is known about the capacity of skeletal muscle for the metabolism of fatty acids in obesity-related insulin resistance, though it is evident that dry cow muscles may contain increased triglyceride content. The current study was therefore undertaken to evaluate the skeletal muscle expression of proteins of the fatty acid metabolism in dry cows with different body condition scores (BCS). Sixteen Holstein-Friesian close-up cows were divided into 2 equal groups based on their BCS as optimal (3.25 ≤ BCS ≤ 3.5) and high (4.0 ≤ BCS ≤ 4.25). Blood samples collection and skeletal muscle biopsies were carried out at day 10 before calving. Blood serum was assayed for concentration of resistin using a bovine specific ELISA. Protein expression of insulin receptor beta subunit (IRβ), glucose transporter 4 (GLUT4), fatty acid translocase (FAT/CD36), fatty acid transporter 1 (FATP1), carnitine palmitoyltransferase 1 (CPT1), AMP-acitvated protein kinase (AMPK) and lipin 1 were analyzed in semitendinosus muscle by immunoblot. Resistin differed non-significantly between high-BCS and optimal-BCS cows. Insulin-resistant lipid metabolism in obese cows was paralleled with increased skeletal muscle expression of lipin 1 and GLUT4, and decreased expression of IRβ and FATP1. These data suggest that in obesity-related insulin resistance, metabolic capacity in dry cow skeletal muscles appears to be organized towards the synthesis of signaling intermediates rather than fatty acids oxidation and that altered fatty acid uptake does not contribute to this disposition.",
journal = "Research in Veterinary Science",
title = "Obesity-related prepartal insulin resistance in dairy cows is associated with increased lipin 1 and decreased FATP 1 expression in skeletal muscle",
volume = "150",
pages = "189-194",
doi = "10.1016/j.rvsc.2022.04.012"
}
Prodanović, R., Kirovski, D., Vujanac, I., Đorđević, A., Romić, S. Đ., Pantelić, M.,& Korićanac, G.. (2022). Obesity-related prepartal insulin resistance in dairy cows is associated with increased lipin 1 and decreased FATP 1 expression in skeletal muscle. in Research in Veterinary Science, 150, 189-194.
https://doi.org/10.1016/j.rvsc.2022.04.012
Prodanović R, Kirovski D, Vujanac I, Đorđević A, Romić SĐ, Pantelić M, Korićanac G. Obesity-related prepartal insulin resistance in dairy cows is associated with increased lipin 1 and decreased FATP 1 expression in skeletal muscle. in Research in Veterinary Science. 2022;150:189-194.
doi:10.1016/j.rvsc.2022.04.012 .
Prodanović, Radiša, Kirovski, Danijela, Vujanac, Ivan, Đorđević, Ana, Romić, Snježana Đ., Pantelić, Marija, Korićanac, Goran, "Obesity-related prepartal insulin resistance in dairy cows is associated with increased lipin 1 and decreased FATP 1 expression in skeletal muscle" in Research in Veterinary Science, 150 (2022):189-194,
https://doi.org/10.1016/j.rvsc.2022.04.012 . .

Biochemical changes in cancer cells induced by photoactive nanosystem based on carbon dots loaded with Ru-complex

Nešić, Maja D.; Dučić, Tanja; Gonçalves, Mara; Stepić, Milutin; Algarra, Manuel; Soto, Juan; Gemović, Branislava S.; Bandosz, Teresa J.; Petković, Marijana

(2022)

TY  - JOUR
AU  - Nešić, Maja D.
AU  - Dučić, Tanja
AU  - Gonçalves, Mara
AU  - Stepić, Milutin
AU  - Algarra, Manuel
AU  - Soto, Juan
AU  - Gemović, Branislava S.
AU  - Bandosz, Teresa J.
AU  - Petković, Marijana
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10267
AB  - Carbon dots (CDs) and N-carbon dots (N-CDs) loaded with Ru-complex (CDs@RuCN, N-CDs@RuCN, respectively) were investigated as media imposing biochemical changes induced by UV illumination of ovarian cancer, A2780, and osteosarcoma, CAL72, cells. Synchrotron radiation-based Fourier Transform Infrared Spectroscopy was performed, and the spectra were subjected to a Principal Component Analysis. The CDs@RuCN and N-CDs@RuCN effects on cancer cells were analyzed by the theoretical modelling of the stability of the composite systems and a protein database search. Moreover, a detailed evaluation of surface and optical properties of CDs@RuCN and N-CDs@RuCN was carried out. Results demonstrated selective action of the CDs@RuCN and N-CDs@RuCN-based photodynamic therapy, with N-CDs@RuCN being the most active in inducing changes in A2780 and CDs@RuCN in CAL72 cells. We assume that different surface charges of nanoparticles led to direct interactions of N-CDs@RuCN with a Wnt signalling pathway in A2780 and those of CDs@RuCN with PI3–K/Akt in CAL72 cells and that further biochemical changes occurred upon light illumination.
T2  - Chemico-Biological Interactions
T1  - Biochemical changes in cancer cells induced by photoactive nanosystem based on carbon dots loaded with Ru-complex
VL  - 360
SP  - 109950
DO  - 10.1016/j.cbi.2022.109950
ER  - 
@article{
author = "Nešić, Maja D. and Dučić, Tanja and Gonçalves, Mara and Stepić, Milutin and Algarra, Manuel and Soto, Juan and Gemović, Branislava S. and Bandosz, Teresa J. and Petković, Marijana",
year = "2022",
abstract = "Carbon dots (CDs) and N-carbon dots (N-CDs) loaded with Ru-complex (CDs@RuCN, N-CDs@RuCN, respectively) were investigated as media imposing biochemical changes induced by UV illumination of ovarian cancer, A2780, and osteosarcoma, CAL72, cells. Synchrotron radiation-based Fourier Transform Infrared Spectroscopy was performed, and the spectra were subjected to a Principal Component Analysis. The CDs@RuCN and N-CDs@RuCN effects on cancer cells were analyzed by the theoretical modelling of the stability of the composite systems and a protein database search. Moreover, a detailed evaluation of surface and optical properties of CDs@RuCN and N-CDs@RuCN was carried out. Results demonstrated selective action of the CDs@RuCN and N-CDs@RuCN-based photodynamic therapy, with N-CDs@RuCN being the most active in inducing changes in A2780 and CDs@RuCN in CAL72 cells. We assume that different surface charges of nanoparticles led to direct interactions of N-CDs@RuCN with a Wnt signalling pathway in A2780 and those of CDs@RuCN with PI3–K/Akt in CAL72 cells and that further biochemical changes occurred upon light illumination.",
journal = "Chemico-Biological Interactions",
title = "Biochemical changes in cancer cells induced by photoactive nanosystem based on carbon dots loaded with Ru-complex",
volume = "360",
pages = "109950",
doi = "10.1016/j.cbi.2022.109950"
}
Nešić, M. D., Dučić, T., Gonçalves, M., Stepić, M., Algarra, M., Soto, J., Gemović, B. S., Bandosz, T. J.,& Petković, M.. (2022). Biochemical changes in cancer cells induced by photoactive nanosystem based on carbon dots loaded with Ru-complex. in Chemico-Biological Interactions, 360, 109950.
https://doi.org/10.1016/j.cbi.2022.109950
Nešić MD, Dučić T, Gonçalves M, Stepić M, Algarra M, Soto J, Gemović BS, Bandosz TJ, Petković M. Biochemical changes in cancer cells induced by photoactive nanosystem based on carbon dots loaded with Ru-complex. in Chemico-Biological Interactions. 2022;360:109950.
doi:10.1016/j.cbi.2022.109950 .
Nešić, Maja D., Dučić, Tanja, Gonçalves, Mara, Stepić, Milutin, Algarra, Manuel, Soto, Juan, Gemović, Branislava S., Bandosz, Teresa J., Petković, Marijana, "Biochemical changes in cancer cells induced by photoactive nanosystem based on carbon dots loaded with Ru-complex" in Chemico-Biological Interactions, 360 (2022):109950,
https://doi.org/10.1016/j.cbi.2022.109950 . .
1

Combined analysis of KRAS mutation and p16INK4a and p14ARF methylation status in locally advanced rectal carcinoma treated with preoperative chemoradiotherapy

Kožik, Bojana; Krajnović, Milena M.; Kokanov, Nikola; Jovanović-Ćupić, Snežana P.; Božović, Ana M.; Todorović, Lidija; Mandušić, Vesna

(2022)

TY  - JOUR
AU  - Kožik, Bojana
AU  - Krajnović, Milena M.
AU  - Kokanov, Nikola
AU  - Jovanović-Ćupić, Snežana P.
AU  - Božović, Ana M.
AU  - Todorović, Lidija
AU  - Mandušić, Vesna
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10354
AB  - Paper description:Patient responses to standard treatment of advanced stages of rectal carcinoma are variable, which emphasizes the need to define reliable predictive and prognostic molecular parameters.We propose a model of simultaneous analysis of KRAS gene mutation status and p16INK4a and p14ARF gene promoter methylation status in pre-treatment tumor biopsies.The simultaneous presence of p14ARF methylation and KRAS mutation was associated with more aggressive tumor behavior. The concurrent presence of alterations in all three examined genes was associated with shorter overall survival.Combined analysis of examined gene alterations revealed patient subgroups with a distinct pattern of tumor response and disease outcome.Abstract: Current management of locally advanced rectal carcinoma (LARC) involves preoperative chemoradiotherapy (preCRT) before surgery. Despite improved local control rate, the response to preCRT of individual patients is variable and may reflect heterogeneous biological properties among tumors of the same clinical stage. Identifying novel molecular parameters with predictive and/or prognostic value is of great clinical importance for a personalized therapeutic approach. In this study, KRAS mutation status was analyzed by direct sequencing, while methylation-specific polymerase chain reaction (MSP) was used to examine p16INK4a and p14ARF gene methylation status in pretreatment tumor biopsies of 60 patients with LARC. The examined molecular changes of KRAS, p16INK4a and p14ARF genes were mutually independent (p16INK4a/KRAS, P=0.272; p14ARF/KRAS, P=0.923; p16INK4a/p14ARF, P=0.715). However, the simultaneous presence of p14ARF methylation and KRAS mutation was associated with a more frequent appearance of local recurrences and distant metastasis (P=0.027). Moreover, patients with the simultaneous presence of p16INK4a and p14ARF methylation and KRAS mutation had significantly shorter overall survival (P=0.011). The obtained results strongly suggest that combined analyses of examined genetic and epigenetic molecular alterations could contribute to the identification of LARC patient subgroups with more aggressive tumor behavior and worse disease outcome.
T2  - Archives of Biological Sciences
T1  - Combined analysis of KRAS mutation and p16INK4a and p14ARF methylation status in locally advanced rectal carcinoma treated with preoperative chemoradiotherapy
VL  - 74
IS  - 2
SP  - 127
EP  - 134
DO  - 10.2298/ABS220222011K
ER  - 
@article{
author = "Kožik, Bojana and Krajnović, Milena M. and Kokanov, Nikola and Jovanović-Ćupić, Snežana P. and Božović, Ana M. and Todorović, Lidija and Mandušić, Vesna",
year = "2022",
abstract = "Paper description:Patient responses to standard treatment of advanced stages of rectal carcinoma are variable, which emphasizes the need to define reliable predictive and prognostic molecular parameters.We propose a model of simultaneous analysis of KRAS gene mutation status and p16INK4a and p14ARF gene promoter methylation status in pre-treatment tumor biopsies.The simultaneous presence of p14ARF methylation and KRAS mutation was associated with more aggressive tumor behavior. The concurrent presence of alterations in all three examined genes was associated with shorter overall survival.Combined analysis of examined gene alterations revealed patient subgroups with a distinct pattern of tumor response and disease outcome.Abstract: Current management of locally advanced rectal carcinoma (LARC) involves preoperative chemoradiotherapy (preCRT) before surgery. Despite improved local control rate, the response to preCRT of individual patients is variable and may reflect heterogeneous biological properties among tumors of the same clinical stage. Identifying novel molecular parameters with predictive and/or prognostic value is of great clinical importance for a personalized therapeutic approach. In this study, KRAS mutation status was analyzed by direct sequencing, while methylation-specific polymerase chain reaction (MSP) was used to examine p16INK4a and p14ARF gene methylation status in pretreatment tumor biopsies of 60 patients with LARC. The examined molecular changes of KRAS, p16INK4a and p14ARF genes were mutually independent (p16INK4a/KRAS, P=0.272; p14ARF/KRAS, P=0.923; p16INK4a/p14ARF, P=0.715). However, the simultaneous presence of p14ARF methylation and KRAS mutation was associated with a more frequent appearance of local recurrences and distant metastasis (P=0.027). Moreover, patients with the simultaneous presence of p16INK4a and p14ARF methylation and KRAS mutation had significantly shorter overall survival (P=0.011). The obtained results strongly suggest that combined analyses of examined genetic and epigenetic molecular alterations could contribute to the identification of LARC patient subgroups with more aggressive tumor behavior and worse disease outcome.",
journal = "Archives of Biological Sciences",
title = "Combined analysis of KRAS mutation and p16INK4a and p14ARF methylation status in locally advanced rectal carcinoma treated with preoperative chemoradiotherapy",
volume = "74",
number = "2",
pages = "127-134",
doi = "10.2298/ABS220222011K"
}
Kožik, B., Krajnović, M. M., Kokanov, N., Jovanović-Ćupić, S. P., Božović, A. M., Todorović, L.,& Mandušić, V.. (2022). Combined analysis of KRAS mutation and p16INK4a and p14ARF methylation status in locally advanced rectal carcinoma treated with preoperative chemoradiotherapy. in Archives of Biological Sciences, 74(2), 127-134.
https://doi.org/10.2298/ABS220222011K
Kožik B, Krajnović MM, Kokanov N, Jovanović-Ćupić SP, Božović AM, Todorović L, Mandušić V. Combined analysis of KRAS mutation and p16INK4a and p14ARF methylation status in locally advanced rectal carcinoma treated with preoperative chemoradiotherapy. in Archives of Biological Sciences. 2022;74(2):127-134.
doi:10.2298/ABS220222011K .
Kožik, Bojana, Krajnović, Milena M., Kokanov, Nikola, Jovanović-Ćupić, Snežana P., Božović, Ana M., Todorović, Lidija, Mandušić, Vesna, "Combined analysis of KRAS mutation and p16INK4a and p14ARF methylation status in locally advanced rectal carcinoma treated with preoperative chemoradiotherapy" in Archives of Biological Sciences, 74, no. 2 (2022):127-134,
https://doi.org/10.2298/ABS220222011K . .

Photoacoustic Analysis of Illuminated Si-TiO2 Sample Bending Along the Heat-Flow Axes

Aleksić, Sanja M.; Markushev, Dragana K.; Markushev, Dragan D.; Pantić, Dragan S.; Lukić, D. V.; Popović, Marica N.; Galović, Slobodanka

(2022)

TY  - JOUR
AU  - Aleksić, Sanja M.
AU  - Markushev, Dragana K.
AU  - Markushev, Dragan D.
AU  - Pantić, Dragan S.
AU  - Lukić, D. V.
AU  - Popović, Marica N.
AU  - Galović, Slobodanka
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10166
AB  - This paper describes the influence of thin transparent film on thermal and elastic characteristics of the two-layer sample consisting of the silicon substrate and thin TiO2 film using analysis of photoacoustic signals and their components in the 20 Hz – 20 kHz frequency domain. Through thermoelastic component changes, it was found that the thin film significantly changes the thermal state of the substrate and makes the degree of its bending increase drastically. The relationships between the thermoelastic component, the displacement along the heat flux axis and the difference of carrier density and temperatures on the different sides of the sample are described. It has been shown that the addition of a thin transparent film to a silicon substrate can effectively reduce the influence of photogenerated carriers in the substrate, especially on its degree of flexibility and restore it efficiently.
T2  - Silicon
T1  - Photoacoustic Analysis of Illuminated Si-TiO2 Sample Bending Along the Heat-Flow Axes
DO  - 10.1007/s12633-022-01723-6
ER  - 
@article{
author = "Aleksić, Sanja M. and Markushev, Dragana K. and Markushev, Dragan D. and Pantić, Dragan S. and Lukić, D. V. and Popović, Marica N. and Galović, Slobodanka",
year = "2022",
abstract = "This paper describes the influence of thin transparent film on thermal and elastic characteristics of the two-layer sample consisting of the silicon substrate and thin TiO2 film using analysis of photoacoustic signals and their components in the 20 Hz – 20 kHz frequency domain. Through thermoelastic component changes, it was found that the thin film significantly changes the thermal state of the substrate and makes the degree of its bending increase drastically. The relationships between the thermoelastic component, the displacement along the heat flux axis and the difference of carrier density and temperatures on the different sides of the sample are described. It has been shown that the addition of a thin transparent film to a silicon substrate can effectively reduce the influence of photogenerated carriers in the substrate, especially on its degree of flexibility and restore it efficiently.",
journal = "Silicon",
title = "Photoacoustic Analysis of Illuminated Si-TiO2 Sample Bending Along the Heat-Flow Axes",
doi = "10.1007/s12633-022-01723-6"
}
Aleksić, S. M., Markushev, D. K., Markushev, D. D., Pantić, D. S., Lukić, D. V., Popović, M. N.,& Galović, S.. (2022). Photoacoustic Analysis of Illuminated Si-TiO2 Sample Bending Along the Heat-Flow Axes. in Silicon.
https://doi.org/10.1007/s12633-022-01723-6
Aleksić SM, Markushev DK, Markushev DD, Pantić DS, Lukić DV, Popović MN, Galović S. Photoacoustic Analysis of Illuminated Si-TiO2 Sample Bending Along the Heat-Flow Axes. in Silicon. 2022;.
doi:10.1007/s12633-022-01723-6 .
Aleksić, Sanja M., Markushev, Dragana K., Markushev, Dragan D., Pantić, Dragan S., Lukić, D. V., Popović, Marica N., Galović, Slobodanka, "Photoacoustic Analysis of Illuminated Si-TiO2 Sample Bending Along the Heat-Flow Axes" in Silicon (2022),
https://doi.org/10.1007/s12633-022-01723-6 . .

Enhancement of the thermoelastic component of the photoacoustic signal of silicon membranes coated with a thin TiO2 film

Markushev, Dragana K.; Markushev, Dragan D.; Aleksić, Sanja M.; Pantić, Dragan S.; Galović, Slobodanka; Lukić, D V; Ordonez-Miranda, Jose

(2022)

TY  - JOUR
AU  - Markushev, Dragana K.
AU  - Markushev, Dragan D.
AU  - Aleksić, Sanja M.
AU  - Pantić, Dragan S.
AU  - Galović, Slobodanka
AU  - Lukić, D V
AU  - Ordonez-Miranda, Jose
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10198
AB  - The reduction of the photogenerated charge carriers' influence in periodically illuminated thin silicon membranes is investigated by using the experimental setup of an open photoacoustic cell in the standard range of modulation frequencies from 20 Hz to 20 kHz. It is confirmed that the deposition of a 200 nm thin film of titanium dioxide on the 30- and 50 μm silicon membrane leads to a large increase of the thermoelastic component of the photoacoustic signal, which restores the flexibility lost to the membrane under the influence of photogenerated carriers. The effect of the thermoelastic component enhancement is analyzed by observing the displacement of the tested samples along the heat propagation axis, depending on the carrier density and temperature differences on the illuminated and unilluminated sides, for different membrane thicknesses and a constant film thickness. It is found that the effect of enhancement of several orders of magnitude is more visible in thinner membranes due to higher ratios between the film and membrane thicknesses.
T2  - Journal of Applied Physics
T1  - Enhancement of the thermoelastic component of the photoacoustic signal of silicon membranes coated with a thin TiO2 film
VL  - 131
IS  - 8
SP  - 085105
DO  - 10.1063/5.0079902
ER  - 
@article{
author = "Markushev, Dragana K. and Markushev, Dragan D. and Aleksić, Sanja M. and Pantić, Dragan S. and Galović, Slobodanka and Lukić, D V and Ordonez-Miranda, Jose",
year = "2022",
abstract = "The reduction of the photogenerated charge carriers' influence in periodically illuminated thin silicon membranes is investigated by using the experimental setup of an open photoacoustic cell in the standard range of modulation frequencies from 20 Hz to 20 kHz. It is confirmed that the deposition of a 200 nm thin film of titanium dioxide on the 30- and 50 μm silicon membrane leads to a large increase of the thermoelastic component of the photoacoustic signal, which restores the flexibility lost to the membrane under the influence of photogenerated carriers. The effect of the thermoelastic component enhancement is analyzed by observing the displacement of the tested samples along the heat propagation axis, depending on the carrier density and temperature differences on the illuminated and unilluminated sides, for different membrane thicknesses and a constant film thickness. It is found that the effect of enhancement of several orders of magnitude is more visible in thinner membranes due to higher ratios between the film and membrane thicknesses.",
journal = "Journal of Applied Physics",
title = "Enhancement of the thermoelastic component of the photoacoustic signal of silicon membranes coated with a thin TiO2 film",
volume = "131",
number = "8",
pages = "085105",
doi = "10.1063/5.0079902"
}
Markushev, D. K., Markushev, D. D., Aleksić, S. M., Pantić, D. S., Galović, S., Lukić, D. V.,& Ordonez-Miranda, J.. (2022). Enhancement of the thermoelastic component of the photoacoustic signal of silicon membranes coated with a thin TiO2 film. in Journal of Applied Physics, 131(8), 085105.
https://doi.org/10.1063/5.0079902
Markushev DK, Markushev DD, Aleksić SM, Pantić DS, Galović S, Lukić DV, Ordonez-Miranda J. Enhancement of the thermoelastic component of the photoacoustic signal of silicon membranes coated with a thin TiO2 film. in Journal of Applied Physics. 2022;131(8):085105.
doi:10.1063/5.0079902 .
Markushev, Dragana K., Markushev, Dragan D., Aleksić, Sanja M., Pantić, Dragan S., Galović, Slobodanka, Lukić, D V, Ordonez-Miranda, Jose, "Enhancement of the thermoelastic component of the photoacoustic signal of silicon membranes coated with a thin TiO2 film" in Journal of Applied Physics, 131, no. 8 (2022):085105,
https://doi.org/10.1063/5.0079902 . .
1

Electronic characterization of plasma-thick n-type silicon using neural networks and photoacoustic response

Đorđević, Katarina Lj.; Galović, Slobodanka; Ćojbašić, Žarko М.; Markushev, Dragan D.; Markushev, Dragana K.; Aleksić, Sanja M.; Pantić, Damjan S.

(2022)

TY  - JOUR
AU  - Đorđević, Katarina Lj.
AU  - Galović, Slobodanka
AU  - Ćojbašić, Žarko М.
AU  - Markushev, Dragan D.
AU  - Markushev, Dragana K.
AU  - Aleksić, Sanja M.
AU  - Pantić, Damjan S.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10349
AB  - In this paper, electronic semiconductor characterization using reverse-back procedure was applied to different photoacoustic responses aiming to find effective ambipolar diffusion coefficient and a bulk lifetime of the minority carriers. The main idea was to find the small fluctuations in investigated parameters due to detecting possible unwanted sample contaminations and temperature variations during the measurements. The mentioned procedure was based on the application of neural networks. Knowing that in experiments the contaminated surfaces of the sample can play a significant role in the global recombination process that we are measuring and that the unintentionally introduced defects of the sample crystal lattice could vary the carrier lifetime by several orders of magnitude, a method of PA signal adjustment by the reverse-back procedure is developed, based on the changes of the carrier electronic parameters.
T2  - Optical and Quantum Electronics
T1  - Electronic characterization of plasma-thick n-type silicon using neural networks and photoacoustic response
VL  - 54
IS  - 8
SP  - 485
DO  - 10.1007/s11082-022-03808-3
ER  - 
@article{
author = "Đorđević, Katarina Lj. and Galović, Slobodanka and Ćojbašić, Žarko М. and Markushev, Dragan D. and Markushev, Dragana K. and Aleksić, Sanja M. and Pantić, Damjan S.",
year = "2022",
abstract = "In this paper, electronic semiconductor characterization using reverse-back procedure was applied to different photoacoustic responses aiming to find effective ambipolar diffusion coefficient and a bulk lifetime of the minority carriers. The main idea was to find the small fluctuations in investigated parameters due to detecting possible unwanted sample contaminations and temperature variations during the measurements. The mentioned procedure was based on the application of neural networks. Knowing that in experiments the contaminated surfaces of the sample can play a significant role in the global recombination process that we are measuring and that the unintentionally introduced defects of the sample crystal lattice could vary the carrier lifetime by several orders of magnitude, a method of PA signal adjustment by the reverse-back procedure is developed, based on the changes of the carrier electronic parameters.",
journal = "Optical and Quantum Electronics",
title = "Electronic characterization of plasma-thick n-type silicon using neural networks and photoacoustic response",
volume = "54",
number = "8",
pages = "485",
doi = "10.1007/s11082-022-03808-3"
}
Đorđević, K. Lj., Galović, S., Ćojbašić, Ž. М., Markushev, D. D., Markushev, D. K., Aleksić, S. M.,& Pantić, D. S.. (2022). Electronic characterization of plasma-thick n-type silicon using neural networks and photoacoustic response. in Optical and Quantum Electronics, 54(8), 485.
https://doi.org/10.1007/s11082-022-03808-3
Đorđević KL, Galović S, Ćojbašić ŽМ, Markushev DD, Markushev DK, Aleksić SM, Pantić DS. Electronic characterization of plasma-thick n-type silicon using neural networks and photoacoustic response. in Optical and Quantum Electronics. 2022;54(8):485.
doi:10.1007/s11082-022-03808-3 .
Đorđević, Katarina Lj., Galović, Slobodanka, Ćojbašić, Žarko М., Markushev, Dragan D., Markushev, Dragana K., Aleksić, Sanja M., Pantić, Damjan S., "Electronic characterization of plasma-thick n-type silicon using neural networks and photoacoustic response" in Optical and Quantum Electronics, 54, no. 8 (2022):485,
https://doi.org/10.1007/s11082-022-03808-3 . .

Photothermal Response of Polymeric Materials Including Complex Heat Capacity

Đorđević, Katarina Lj.; Miličević, Dejan S.; Galović, Slobodanka; Suljovrujić, Edin H.; Jaćimovski, Stevo K.; Furundžić, Draško; Popović, Marica N.

(2022)

TY  - JOUR
AU  - Đorđević, Katarina Lj.
AU  - Miličević, Dejan S.
AU  - Galović, Slobodanka
AU  - Suljovrujić, Edin H.
AU  - Jaćimovski, Stevo K.
AU  - Furundžić, Draško
AU  - Popović, Marica N.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10196
AB  - The paper presents a generalized model of the photothermal response of a polymer sample. The model is based on a linear non-Fourier heat conduction equation that considers thermal memory and complex heat capacity. The physical meaning of imaginary heat capacity is discussed from the point of view of non-equilibrium thermodynamics. The derived heat conduction equation introduces two additional dynamic properties of a medium to time-varying heat conduction: inertial and kinetic relaxation time. The influence of these relaxation times on photothermal response is analyzed. It is shown that the derived model could explain the measured photoacoustic response of different semi-crystalline polyethylenes (PEs). The obtained results show that photothermal techniques can be employed to estimate relaxation phenomena in polymeric materials when the frequency scale of the experiment is greater than the inverse value of any relaxation time. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
T2  - International Journal of Thermophysics
T1  - Photothermal Response of Polymeric Materials Including Complex Heat Capacity
VL  - 43
IS  - 5
SP  - 68
DO  - 10.1007/s10765-022-02985-3
ER  - 
@article{
author = "Đorđević, Katarina Lj. and Miličević, Dejan S. and Galović, Slobodanka and Suljovrujić, Edin H. and Jaćimovski, Stevo K. and Furundžić, Draško and Popović, Marica N.",
year = "2022",
abstract = "The paper presents a generalized model of the photothermal response of a polymer sample. The model is based on a linear non-Fourier heat conduction equation that considers thermal memory and complex heat capacity. The physical meaning of imaginary heat capacity is discussed from the point of view of non-equilibrium thermodynamics. The derived heat conduction equation introduces two additional dynamic properties of a medium to time-varying heat conduction: inertial and kinetic relaxation time. The influence of these relaxation times on photothermal response is analyzed. It is shown that the derived model could explain the measured photoacoustic response of different semi-crystalline polyethylenes (PEs). The obtained results show that photothermal techniques can be employed to estimate relaxation phenomena in polymeric materials when the frequency scale of the experiment is greater than the inverse value of any relaxation time. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.",
journal = "International Journal of Thermophysics",
title = "Photothermal Response of Polymeric Materials Including Complex Heat Capacity",
volume = "43",
number = "5",
pages = "68",
doi = "10.1007/s10765-022-02985-3"
}
Đorđević, K. Lj., Miličević, D. S., Galović, S., Suljovrujić, E. H., Jaćimovski, S. K., Furundžić, D.,& Popović, M. N.. (2022). Photothermal Response of Polymeric Materials Including Complex Heat Capacity. in International Journal of Thermophysics, 43(5), 68.
https://doi.org/10.1007/s10765-022-02985-3
Đorđević KL, Miličević DS, Galović S, Suljovrujić EH, Jaćimovski SK, Furundžić D, Popović MN. Photothermal Response of Polymeric Materials Including Complex Heat Capacity. in International Journal of Thermophysics. 2022;43(5):68.
doi:10.1007/s10765-022-02985-3 .
Đorđević, Katarina Lj., Miličević, Dejan S., Galović, Slobodanka, Suljovrujić, Edin H., Jaćimovski, Stevo K., Furundžić, Draško, Popović, Marica N., "Photothermal Response of Polymeric Materials Including Complex Heat Capacity" in International Journal of Thermophysics, 43, no. 5 (2022):68,
https://doi.org/10.1007/s10765-022-02985-3 . .
1

Tag Variants of LGALS-3 Containing Haplotype Block in Advanced Carotid Atherosclerosis

Đorđević, Ana; Živković, Maja; Končar, Igor; Stanković, Aleksandra; Kuveljić, Jovana; Đurić, Tamara

(2022)

TY  - JOUR
AU  - Đorđević, Ana
AU  - Živković, Maja
AU  - Končar, Igor
AU  - Stanković, Aleksandra
AU  - Kuveljić, Jovana
AU  - Đurić, Tamara
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10046
AB  - ObjectivesGalectin-3 affects a variety of biological processes. It is encoded by LGALS-3, located in unique haplotype block in Caucasians. Most of the studies regarding the gal-3 role in atherosclerosis are focused exclusively on protein/mRNA levels. Genetic analyses of LGALS-3 are scarce. We sought to thoroughly examine the genetic background of gal-3 and to analyze tag variants that cover more than 80% variability of the LGALS-3 containing hap-block in association with carotid plaque presence (CPP). According to Tagger server, rs4040064 G/T, rs11628437 G/A and rs7159490 C/T cover 82% (r2 > 0.8) of the genetic variance of this hap-block. Our aims were to investigate possible association of rs4040064, rs11628437 and rs7159490 haplotypes with CPP in patients with advanced carotid atherosclerosis (CA) and to analyze their possible effect on LGALS-3 mRNA expression in carotid plaques.Materials and methodsStudy group consisted of 468 patients and 296 controls. Rs4040064, rs11628437, rs7159490 and LGALS-3 mRNA expression were detected by TaqMan® technology.ResultsWe have found that haplotype TAC was associated with the cerebrovascular insult (CVI) occurrence (OR = 1.68, 95% CI = 1.09-2.58, p = 0.02), compared to the referent haplotype. OR was adjusted for hypertension, age and BMI. TAC also showed higher, but not statistically significant, LGALS-3 expression in carotid plaques.ConclusionsOur results suggest that rs4040064, rs11628437 and rs7159490 bear no association with CPP, neither they affect LGALS-3 mRNA in carotid plaques. However, we showed a significant association of haplotype TAC with the CVI occurrence in CA patients from Serbia. Replication and validation of our results are required.
T2  - Journal of Stroke and Cerebrovascular Diseases
T2  - Journal of Stroke and Cerebrovascular DiseasesJournal of Stroke and Cerebrovascular Diseases
T1  - Tag Variants of LGALS-3 Containing Haplotype Block in Advanced Carotid Atherosclerosis
VL  - 31
IS  - 1
SP  - 106212
DO  - 10.1016/j.jstrokecerebrovasdis.2021.106212
ER  - 
@article{
author = "Đorđević, Ana and Živković, Maja and Končar, Igor and Stanković, Aleksandra and Kuveljić, Jovana and Đurić, Tamara",
year = "2022",
abstract = "ObjectivesGalectin-3 affects a variety of biological processes. It is encoded by LGALS-3, located in unique haplotype block in Caucasians. Most of the studies regarding the gal-3 role in atherosclerosis are focused exclusively on protein/mRNA levels. Genetic analyses of LGALS-3 are scarce. We sought to thoroughly examine the genetic background of gal-3 and to analyze tag variants that cover more than 80% variability of the LGALS-3 containing hap-block in association with carotid plaque presence (CPP). According to Tagger server, rs4040064 G/T, rs11628437 G/A and rs7159490 C/T cover 82% (r2 > 0.8) of the genetic variance of this hap-block. Our aims were to investigate possible association of rs4040064, rs11628437 and rs7159490 haplotypes with CPP in patients with advanced carotid atherosclerosis (CA) and to analyze their possible effect on LGALS-3 mRNA expression in carotid plaques.Materials and methodsStudy group consisted of 468 patients and 296 controls. Rs4040064, rs11628437, rs7159490 and LGALS-3 mRNA expression were detected by TaqMan® technology.ResultsWe have found that haplotype TAC was associated with the cerebrovascular insult (CVI) occurrence (OR = 1.68, 95% CI = 1.09-2.58, p = 0.02), compared to the referent haplotype. OR was adjusted for hypertension, age and BMI. TAC also showed higher, but not statistically significant, LGALS-3 expression in carotid plaques.ConclusionsOur results suggest that rs4040064, rs11628437 and rs7159490 bear no association with CPP, neither they affect LGALS-3 mRNA in carotid plaques. However, we showed a significant association of haplotype TAC with the CVI occurrence in CA patients from Serbia. Replication and validation of our results are required.",
journal = "Journal of Stroke and Cerebrovascular Diseases, Journal of Stroke and Cerebrovascular DiseasesJournal of Stroke and Cerebrovascular Diseases",
title = "Tag Variants of LGALS-3 Containing Haplotype Block in Advanced Carotid Atherosclerosis",
volume = "31",
number = "1",
pages = "106212",
doi = "10.1016/j.jstrokecerebrovasdis.2021.106212"
}
Đorđević, A., Živković, M., Končar, I., Stanković, A., Kuveljić, J.,& Đurić, T.. (2022). Tag Variants of LGALS-3 Containing Haplotype Block in Advanced Carotid Atherosclerosis. in Journal of Stroke and Cerebrovascular Diseases, 31(1), 106212.
https://doi.org/10.1016/j.jstrokecerebrovasdis.2021.106212
Đorđević A, Živković M, Končar I, Stanković A, Kuveljić J, Đurić T. Tag Variants of LGALS-3 Containing Haplotype Block in Advanced Carotid Atherosclerosis. in Journal of Stroke and Cerebrovascular Diseases. 2022;31(1):106212.
doi:10.1016/j.jstrokecerebrovasdis.2021.106212 .
Đorđević, Ana, Živković, Maja, Končar, Igor, Stanković, Aleksandra, Kuveljić, Jovana, Đurić, Tamara, "Tag Variants of LGALS-3 Containing Haplotype Block in Advanced Carotid Atherosclerosis" in Journal of Stroke and Cerebrovascular Diseases, 31, no. 1 (2022):106212,
https://doi.org/10.1016/j.jstrokecerebrovasdis.2021.106212 . .

Metabolomic profiling relates tianeptine effectiveness with hippocampal GABA, myo-inositol, cholesterol, and fatty acid metabolism restoration in socially isolated rats

Perić, Ivana; Lješević, Marija; Beškoski, Vladimir P.; Nikolić, Milan; Filipović, Dragana

(2022)

TY  - JOUR
AU  - Perić, Ivana
AU  - Lješević, Marija
AU  - Beškoski, Vladimir P.
AU  - Nikolić, Milan
AU  - Filipović, Dragana
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10355
AB  - Discovering biomarkers of major depressive disorder (MDD) can give a deeper understanding of this mood disorder and improve the ability to screen for, diagnose, and treat MDD.
T2  - Psychopharmacology
T1  - Metabolomic profiling relates tianeptine effectiveness with hippocampal GABA, myo-inositol, cholesterol, and fatty acid metabolism restoration in socially isolated rats
DO  - 10.1007/s00213-022-06180-y
ER  - 
@article{
author = "Perić, Ivana and Lješević, Marija and Beškoski, Vladimir P. and Nikolić, Milan and Filipović, Dragana",
year = "2022",
abstract = "Discovering biomarkers of major depressive disorder (MDD) can give a deeper understanding of this mood disorder and improve the ability to screen for, diagnose, and treat MDD.",
journal = "Psychopharmacology",
title = "Metabolomic profiling relates tianeptine effectiveness with hippocampal GABA, myo-inositol, cholesterol, and fatty acid metabolism restoration in socially isolated rats",
doi = "10.1007/s00213-022-06180-y"
}
Perić, I., Lješević, M., Beškoski, V. P., Nikolić, M.,& Filipović, D.. (2022). Metabolomic profiling relates tianeptine effectiveness with hippocampal GABA, myo-inositol, cholesterol, and fatty acid metabolism restoration in socially isolated rats. in Psychopharmacology.
https://doi.org/10.1007/s00213-022-06180-y
Perić I, Lješević M, Beškoski VP, Nikolić M, Filipović D. Metabolomic profiling relates tianeptine effectiveness with hippocampal GABA, myo-inositol, cholesterol, and fatty acid metabolism restoration in socially isolated rats. in Psychopharmacology. 2022;.
doi:10.1007/s00213-022-06180-y .
Perić, Ivana, Lješević, Marija, Beškoski, Vladimir P., Nikolić, Milan, Filipović, Dragana, "Metabolomic profiling relates tianeptine effectiveness with hippocampal GABA, myo-inositol, cholesterol, and fatty acid metabolism restoration in socially isolated rats" in Psychopharmacology (2022),
https://doi.org/10.1007/s00213-022-06180-y . .

Interfacial charge transfer complex formation between silver nanoparticles and aromatic amino acids

Sredojević, Dušan; Stavrić, Srđan; Lazić, Vesna; Ahrenkiel, S. Phillip; Nedeljković, Jovan

(2022)

TY  - JOUR
AU  - Sredojević, Dušan
AU  - Stavrić, Srđan
AU  - Lazić, Vesna
AU  - Ahrenkiel, S. Phillip
AU  - Nedeljković, Jovan
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10352
AB  - The optical properties of surface-modified silver nanoparticles (Ag NPs) with aromatic amino acids tryptophan (Trp) and histidine (His) were examined using the cluster model for density functional theory (DFT) and time-dependent density functional theory (TD-DFT) calculations. Also, the redistribution of electronic charges upon chemisorption of ligand molecules onto silver's surfaces is determined. The obtained theoretical data, on one side, undoubtedly indicate the the formation of an interfacial charge transfer (ICT) complex between silver and this type of ligand, and, on the other side, partial oxidation of surface silver atoms accompanied by an increase of electron density in ligand molecules. The ICT complex formation, based on noble metal nanoparticles, has never been reported previously to the best of our knowledge. The experimental spectroscopic measurements support the theoretical data. A new absorption band in the visible spectral range appears upon surface modification of Ag NPs, and, when exposed to air, oxidation of surface-modified Ag NPs is significantly faster than the oxidation of the unmodified ones.
T2  - Physical Chemistry Chemical Physics
T2  - Physical Chemistry Chemical PhysicsPhys. Chem. Chem. Phys.
T1  - Interfacial charge transfer complex formation between silver nanoparticles and aromatic amino acids
VL  - 24
IS  - 27
SP  - 16493
EP  - 16500
DO  - 10.1039/D2CP02041F
ER  - 
@article{
author = "Sredojević, Dušan and Stavrić, Srđan and Lazić, Vesna and Ahrenkiel, S. Phillip and Nedeljković, Jovan",
year = "2022",
abstract = "The optical properties of surface-modified silver nanoparticles (Ag NPs) with aromatic amino acids tryptophan (Trp) and histidine (His) were examined using the cluster model for density functional theory (DFT) and time-dependent density functional theory (TD-DFT) calculations. Also, the redistribution of electronic charges upon chemisorption of ligand molecules onto silver's surfaces is determined. The obtained theoretical data, on one side, undoubtedly indicate the the formation of an interfacial charge transfer (ICT) complex between silver and this type of ligand, and, on the other side, partial oxidation of surface silver atoms accompanied by an increase of electron density in ligand molecules. The ICT complex formation, based on noble metal nanoparticles, has never been reported previously to the best of our knowledge. The experimental spectroscopic measurements support the theoretical data. A new absorption band in the visible spectral range appears upon surface modification of Ag NPs, and, when exposed to air, oxidation of surface-modified Ag NPs is significantly faster than the oxidation of the unmodified ones.",
journal = "Physical Chemistry Chemical Physics, Physical Chemistry Chemical PhysicsPhys. Chem. Chem. Phys.",
title = "Interfacial charge transfer complex formation between silver nanoparticles and aromatic amino acids",
volume = "24",
number = "27",
pages = "16493-16500",
doi = "10.1039/D2CP02041F"
}
Sredojević, D., Stavrić, S., Lazić, V., Ahrenkiel, S. P.,& Nedeljković, J.. (2022). Interfacial charge transfer complex formation between silver nanoparticles and aromatic amino acids. in Physical Chemistry Chemical Physics, 24(27), 16493-16500.
https://doi.org/10.1039/D2CP02041F
Sredojević D, Stavrić S, Lazić V, Ahrenkiel SP, Nedeljković J. Interfacial charge transfer complex formation between silver nanoparticles and aromatic amino acids. in Physical Chemistry Chemical Physics. 2022;24(27):16493-16500.
doi:10.1039/D2CP02041F .
Sredojević, Dušan, Stavrić, Srđan, Lazić, Vesna, Ahrenkiel, S. Phillip, Nedeljković, Jovan, "Interfacial charge transfer complex formation between silver nanoparticles and aromatic amino acids" in Physical Chemistry Chemical Physics, 24, no. 27 (2022):16493-16500,
https://doi.org/10.1039/D2CP02041F . .

Self-aggregation of soil humic acids with respect to their structural characteristics

Jovanović, Uroš D.; Marković, Mirjana; Čokeša, Đuro; Živković, Nikola V.; Radmanović, Svjetlana B.

(2022)

TY  - JOUR
AU  - Jovanović, Uroš D.
AU  - Marković, Mirjana
AU  - Čokeša, Đuro
AU  - Živković, Nikola V.
AU  - Radmanović, Svjetlana B.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10351
AB  - The main goal of this work was to estimate the influence of carboxyl and phenolic groups, as well as aromatic, aliphatic and polysaccharide components, on the soil humic acids (HA) self-aggregation process. Soil HAs (leptosol and regosol) were separated using base resin getting fractions with different functional group contents. Blocking of carboxyl groups was performed using the esterification procedure to estimate the participation of each functional group in the HA aggregation. The presence of HA structural components was evaluated by potentiometric titration and ATR-FTIR. The aggregation was monitored at pH 3 using dynamic light scattering. Results indicated that the higher group content, the HA aggregation is less pronounced. A significant positive correlation of aliphatic C and aggregate size revealed their dominant influence in the HA self-aggregation. A lower abundance of aliphatic C in HA fractions could be considered as not sufficient to start the process. An increase of aromatic C in esters likely pointed out to its participation in hydrophobic bonding and, consequently, more pronounced aggregation. The relation of HA self-aggregate size with carboxyl and phenolic group, as well as aliphatic C, at low pH, could be considered universal regardless of the structural characteristics of the original or modified HA forms.
T2  - Journal of the Serbian Chemical Society
T1  - Self-aggregation of soil humic acids with respect to their structural characteristics
VL  - 87
IS  - 6
SP  - 761
EP  - 773
DO  - 10.2298/JSC211125010J
ER  - 
@article{
author = "Jovanović, Uroš D. and Marković, Mirjana and Čokeša, Đuro and Živković, Nikola V. and Radmanović, Svjetlana B.",
year = "2022",
abstract = "The main goal of this work was to estimate the influence of carboxyl and phenolic groups, as well as aromatic, aliphatic and polysaccharide components, on the soil humic acids (HA) self-aggregation process. Soil HAs (leptosol and regosol) were separated using base resin getting fractions with different functional group contents. Blocking of carboxyl groups was performed using the esterification procedure to estimate the participation of each functional group in the HA aggregation. The presence of HA structural components was evaluated by potentiometric titration and ATR-FTIR. The aggregation was monitored at pH 3 using dynamic light scattering. Results indicated that the higher group content, the HA aggregation is less pronounced. A significant positive correlation of aliphatic C and aggregate size revealed their dominant influence in the HA self-aggregation. A lower abundance of aliphatic C in HA fractions could be considered as not sufficient to start the process. An increase of aromatic C in esters likely pointed out to its participation in hydrophobic bonding and, consequently, more pronounced aggregation. The relation of HA self-aggregate size with carboxyl and phenolic group, as well as aliphatic C, at low pH, could be considered universal regardless of the structural characteristics of the original or modified HA forms.",
journal = "Journal of the Serbian Chemical Society",
title = "Self-aggregation of soil humic acids with respect to their structural characteristics",
volume = "87",
number = "6",
pages = "761-773",
doi = "10.2298/JSC211125010J"
}
Jovanović, U. D., Marković, M., Čokeša, Đ., Živković, N. V.,& Radmanović, S. B.. (2022). Self-aggregation of soil humic acids with respect to their structural characteristics. in Journal of the Serbian Chemical Society, 87(6), 761-773.
https://doi.org/10.2298/JSC211125010J
Jovanović UD, Marković M, Čokeša Đ, Živković NV, Radmanović SB. Self-aggregation of soil humic acids with respect to their structural characteristics. in Journal of the Serbian Chemical Society. 2022;87(6):761-773.
doi:10.2298/JSC211125010J .
Jovanović, Uroš D., Marković, Mirjana, Čokeša, Đuro, Živković, Nikola V., Radmanović, Svjetlana B., "Self-aggregation of soil humic acids with respect to their structural characteristics" in Journal of the Serbian Chemical Society, 87, no. 6 (2022):761-773,
https://doi.org/10.2298/JSC211125010J . .

RASSF1A and p16 promoter methylation and treatment response in chronic hepatitis C genotype 1b patients treated with pegylated interferon/ribavirin

Kokanov, Nikola; Krajnović, Milena M.; Jovanović-Ćupić, Snežana P.; Kožik, Bojana; Petrović, Nina; Božović, Ana M.; Mandušić, Vesna

(2022)

TY  - JOUR
AU  - Kokanov, Nikola
AU  - Krajnović, Milena M.
AU  - Jovanović-Ćupić, Snežana P.
AU  - Kožik, Bojana
AU  - Petrović, Nina
AU  - Božović, Ana M.
AU  - Mandušić, Vesna
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10273
AB  - Prevention of chronic hepatitis C (CHC) and its complications is based on antiviral therapy and early detection of reliable molecular markers in persons under risk. We investigated whether the methylation status of RASSF1A and p16 genes, alone or in combination with host and viral factors, affects the response to therapy with pegylated interferon/ribavirin (PEG-IFN/RBV). Methylation-specific polymerase chain reaction (MSP) was used to determine the methylation status of the target promoter sequences of RASSF1A and p16 in circulating-free DNA from the peripheral blood of 49 patients with CHC genotype 1b. The methylation status of the examined genes did not affect the response to therapy. However, the simultaneous presence of either RASSF1A or p16 methylation and the CC genotype of IL28B was significantly related to a sustained virologic response (P=0.009 and P=0.032, respectively). After Bonferroni correction, only the result concerning the RASSF1A gene remained significant (P<0.0125). Methylation of RASSF1A was associated with the CC genotype of the IL28B gene (P=0.024) and a higher viral load (≥400 000 IU/mL, P=0.009). Our results suggest that combined analysis of RASSF1A gene methylation and IL28B rs12979860 polymorphism could potentially help in the prediction of therapy response in CHC genotype 1b patients.
T2  - Archives of Biological Sciences
T1  - RASSF1A and p16 promoter methylation and treatment response in chronic hepatitis C genotype 1b patients treated with pegylated interferon/ribavirin
VL  - 74
IS  - 1
SP  - 57
EP  - 66
DO  - 10.2298/ABS211208004K
ER  - 
@article{
author = "Kokanov, Nikola and Krajnović, Milena M. and Jovanović-Ćupić, Snežana P. and Kožik, Bojana and Petrović, Nina and Božović, Ana M. and Mandušić, Vesna",
year = "2022",
abstract = "Prevention of chronic hepatitis C (CHC) and its complications is based on antiviral therapy and early detection of reliable molecular markers in persons under risk. We investigated whether the methylation status of RASSF1A and p16 genes, alone or in combination with host and viral factors, affects the response to therapy with pegylated interferon/ribavirin (PEG-IFN/RBV). Methylation-specific polymerase chain reaction (MSP) was used to determine the methylation status of the target promoter sequences of RASSF1A and p16 in circulating-free DNA from the peripheral blood of 49 patients with CHC genotype 1b. The methylation status of the examined genes did not affect the response to therapy. However, the simultaneous presence of either RASSF1A or p16 methylation and the CC genotype of IL28B was significantly related to a sustained virologic response (P=0.009 and P=0.032, respectively). After Bonferroni correction, only the result concerning the RASSF1A gene remained significant (P<0.0125). Methylation of RASSF1A was associated with the CC genotype of the IL28B gene (P=0.024) and a higher viral load (≥400 000 IU/mL, P=0.009). Our results suggest that combined analysis of RASSF1A gene methylation and IL28B rs12979860 polymorphism could potentially help in the prediction of therapy response in CHC genotype 1b patients.",
journal = "Archives of Biological Sciences",
title = "RASSF1A and p16 promoter methylation and treatment response in chronic hepatitis C genotype 1b patients treated with pegylated interferon/ribavirin",
volume = "74",
number = "1",
pages = "57-66",
doi = "10.2298/ABS211208004K"
}
Kokanov, N., Krajnović, M. M., Jovanović-Ćupić, S. P., Kožik, B., Petrović, N., Božović, A. M.,& Mandušić, V.. (2022). RASSF1A and p16 promoter methylation and treatment response in chronic hepatitis C genotype 1b patients treated with pegylated interferon/ribavirin. in Archives of Biological Sciences, 74(1), 57-66.
https://doi.org/10.2298/ABS211208004K
Kokanov N, Krajnović MM, Jovanović-Ćupić SP, Kožik B, Petrović N, Božović AM, Mandušić V. RASSF1A and p16 promoter methylation and treatment response in chronic hepatitis C genotype 1b patients treated with pegylated interferon/ribavirin. in Archives of Biological Sciences. 2022;74(1):57-66.
doi:10.2298/ABS211208004K .
Kokanov, Nikola, Krajnović, Milena M., Jovanović-Ćupić, Snežana P., Kožik, Bojana, Petrović, Nina, Božović, Ana M., Mandušić, Vesna, "RASSF1A and p16 promoter methylation and treatment response in chronic hepatitis C genotype 1b patients treated with pegylated interferon/ribavirin" in Archives of Biological Sciences, 74, no. 1 (2022):57-66,
https://doi.org/10.2298/ABS211208004K . .

Antioxidant and cytotoxic activity of red wine after in vitro simulated digestion in the presence of complex food matrix

Đorđević, Neda O.; Stanisavljević, Nemanja; Todorović Vukotić, Nevena; Novović, Katarina; Žakula, Jelena; Stanković, Dalibor; Pajović, Snežana B.

(2022)

TY  - JOUR
AU  - Đorđević, Neda O.
AU  - Stanisavljević, Nemanja
AU  - Todorović Vukotić, Nevena
AU  - Novović, Katarina
AU  - Žakula, Jelena
AU  - Stanković, Dalibor
AU  - Pajović, Snežana B.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10353
AB  - The beneficial effect of moderate wine consumption is attributed to its micronutrients, especially polyphenols and largely depends on the digestion process. This work aimed to examine the influence of in vitro simulated digestion in the presence of complex food matrix on antioxidant and cytotoxic activity of red wine. The obtained results showed that total phenolic content of wine sample after in vitro digestion was higher compared to undigested wine, while the antioxidant activity of these samples was similar before and after digestion. Furthermore, it has been noticed that digested wine showed cytotoxic activity on SKBR3 breast adenocarcinoma cells near 20% after 72 h of treatment. This pioneering study that examined biological potential of in vitro digested wine in the presence of complex food matrix indicate that antioxidant and cytotoxic activity of red wine is preserved after digestion.
T2  - Natural Product Research
T1  - Antioxidant and cytotoxic activity of red wine after in vitro simulated digestion in the presence of complex food matrix
SP  - 1
EP  - 6
DO  - 10.1080/14786419.2022.2095380
ER  - 
@article{
author = "Đorđević, Neda O. and Stanisavljević, Nemanja and Todorović Vukotić, Nevena and Novović, Katarina and Žakula, Jelena and Stanković, Dalibor and Pajović, Snežana B.",
year = "2022",
abstract = "The beneficial effect of moderate wine consumption is attributed to its micronutrients, especially polyphenols and largely depends on the digestion process. This work aimed to examine the influence of in vitro simulated digestion in the presence of complex food matrix on antioxidant and cytotoxic activity of red wine. The obtained results showed that total phenolic content of wine sample after in vitro digestion was higher compared to undigested wine, while the antioxidant activity of these samples was similar before and after digestion. Furthermore, it has been noticed that digested wine showed cytotoxic activity on SKBR3 breast adenocarcinoma cells near 20% after 72 h of treatment. This pioneering study that examined biological potential of in vitro digested wine in the presence of complex food matrix indicate that antioxidant and cytotoxic activity of red wine is preserved after digestion.",
journal = "Natural Product Research",
title = "Antioxidant and cytotoxic activity of red wine after in vitro simulated digestion in the presence of complex food matrix",
pages = "1-6",
doi = "10.1080/14786419.2022.2095380"
}
Đorđević, N. O., Stanisavljević, N., Todorović Vukotić, N., Novović, K., Žakula, J., Stanković, D.,& Pajović, S. B.. (2022). Antioxidant and cytotoxic activity of red wine after in vitro simulated digestion in the presence of complex food matrix. in Natural Product Research, 1-6.
https://doi.org/10.1080/14786419.2022.2095380
Đorđević NO, Stanisavljević N, Todorović Vukotić N, Novović K, Žakula J, Stanković D, Pajović SB. Antioxidant and cytotoxic activity of red wine after in vitro simulated digestion in the presence of complex food matrix. in Natural Product Research. 2022;:1-6.
doi:10.1080/14786419.2022.2095380 .
Đorđević, Neda O., Stanisavljević, Nemanja, Todorović Vukotić, Nevena, Novović, Katarina, Žakula, Jelena, Stanković, Dalibor, Pajović, Snežana B., "Antioxidant and cytotoxic activity of red wine after in vitro simulated digestion in the presence of complex food matrix" in Natural Product Research (2022):1-6,
https://doi.org/10.1080/14786419.2022.2095380 . .

Co(III), Ni(II) and Cu(II) complexes with a tetradentate Schiff base ligand: synthesis, characterization, electrochemical behavior, binding assessment and in vitro cytotoxicity

Mirković, Marija; Radović, Magdalena; Stanković, Dalibor M.; Vranješ-Đurić, Sanja; Janković, Drina; Petrović, Djordje; Mihajlović-Lalić, Ljiljana E.; Prijović, Željko; Milanović, Zorana

(2022)

TY  - JOUR
AU  - Mirković, Marija
AU  - Radović, Magdalena
AU  - Stanković, Dalibor M.
AU  - Vranješ-Đurić, Sanja
AU  - Janković, Drina
AU  - Petrović, Djordje
AU  - Mihajlović-Lalić, Ljiljana E.
AU  - Prijović, Željko
AU  - Milanović, Zorana
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10169
AB  - Two new Schiff base cobalt(III) ([Co(LH)Cl2], 1) and nickel(II) ([Ni(LH)ClO4], 2) complexes with a diimine-dioxime ligand, (4,9-diaza-3,10-diethyl-3,9-dodecadiene-2,11-dione bis oxime (LH2)), were synthesized and characterized. The compounds were obtained in MeOH from corresponding metal salts and LH2 in molar ratio 1:1 and further characterized by mass spectrometry, IR spectroscopy, electrochemistry, and elemental analysis. Previously reported copper(II) analog ([Cu2(LH)2]·(ClO4)2, 3) was joined to 1 and 2, and the three metal analogs, 1–3, were further investigated in terms of their electrochemical behavior. Binding studies of the complexes with deoxyribonucleic acid (DNA) and human serum albumin (HSA) were carried out using both spectrophotometric and electrochemical methods. All three complexes exhibit binding affinity towards the DNA chain through intercalative interactions. The binding reaction with HSA showed for 1 and 3 decrease in the peak current obtained in the case of complexes before the addition of HSA, while the Ni complex–HSA possesses the same electroactivity as starting complex. The cytotoxicity of LH2 as well as its metal complexes, and cisplatin were evaluated on CT-26 mouse colon carcinoma and human LS174T cancer cell lines employing MTT assay. The copper(II) complex exhibited very promising anticancer activity compared with cisplatin.
T2  - Journal of Coordination Chemistry
T1  - Co(III), Ni(II) and Cu(II) complexes with a tetradentate Schiff base ligand: synthesis, characterization, electrochemical behavior, binding assessment and in vitro cytotoxicity
SP  - 1
EP  - 14
DO  - 10.1080/00958972.2022.2032683
ER  - 
@article{
author = "Mirković, Marija and Radović, Magdalena and Stanković, Dalibor M. and Vranješ-Đurić, Sanja and Janković, Drina and Petrović, Djordje and Mihajlović-Lalić, Ljiljana E. and Prijović, Željko and Milanović, Zorana",
year = "2022",
abstract = "Two new Schiff base cobalt(III) ([Co(LH)Cl2], 1) and nickel(II) ([Ni(LH)ClO4], 2) complexes with a diimine-dioxime ligand, (4,9-diaza-3,10-diethyl-3,9-dodecadiene-2,11-dione bis oxime (LH2)), were synthesized and characterized. The compounds were obtained in MeOH from corresponding metal salts and LH2 in molar ratio 1:1 and further characterized by mass spectrometry, IR spectroscopy, electrochemistry, and elemental analysis. Previously reported copper(II) analog ([Cu2(LH)2]·(ClO4)2, 3) was joined to 1 and 2, and the three metal analogs, 1–3, were further investigated in terms of their electrochemical behavior. Binding studies of the complexes with deoxyribonucleic acid (DNA) and human serum albumin (HSA) were carried out using both spectrophotometric and electrochemical methods. All three complexes exhibit binding affinity towards the DNA chain through intercalative interactions. The binding reaction with HSA showed for 1 and 3 decrease in the peak current obtained in the case of complexes before the addition of HSA, while the Ni complex–HSA possesses the same electroactivity as starting complex. The cytotoxicity of LH2 as well as its metal complexes, and cisplatin were evaluated on CT-26 mouse colon carcinoma and human LS174T cancer cell lines employing MTT assay. The copper(II) complex exhibited very promising anticancer activity compared with cisplatin.",
journal = "Journal of Coordination Chemistry",
title = "Co(III), Ni(II) and Cu(II) complexes with a tetradentate Schiff base ligand: synthesis, characterization, electrochemical behavior, binding assessment and in vitro cytotoxicity",
pages = "1-14",
doi = "10.1080/00958972.2022.2032683"
}
Mirković, M., Radović, M., Stanković, D. M., Vranješ-Đurić, S., Janković, D., Petrović, D., Mihajlović-Lalić, L. E., Prijović, Ž.,& Milanović, Z.. (2022). Co(III), Ni(II) and Cu(II) complexes with a tetradentate Schiff base ligand: synthesis, characterization, electrochemical behavior, binding assessment and in vitro cytotoxicity. in Journal of Coordination Chemistry, 1-14.
https://doi.org/10.1080/00958972.2022.2032683
Mirković M, Radović M, Stanković DM, Vranješ-Đurić S, Janković D, Petrović D, Mihajlović-Lalić LE, Prijović Ž, Milanović Z. Co(III), Ni(II) and Cu(II) complexes with a tetradentate Schiff base ligand: synthesis, characterization, electrochemical behavior, binding assessment and in vitro cytotoxicity. in Journal of Coordination Chemistry. 2022;:1-14.
doi:10.1080/00958972.2022.2032683 .
Mirković, Marija, Radović, Magdalena, Stanković, Dalibor M., Vranješ-Đurić, Sanja, Janković, Drina, Petrović, Djordje, Mihajlović-Lalić, Ljiljana E., Prijović, Željko, Milanović, Zorana, "Co(III), Ni(II) and Cu(II) complexes with a tetradentate Schiff base ligand: synthesis, characterization, electrochemical behavior, binding assessment and in vitro cytotoxicity" in Journal of Coordination Chemistry (2022):1-14,
https://doi.org/10.1080/00958972.2022.2032683 . .
1

Antioxidant defense system in the prefrontal cortex of chronically stressed rats treated with lithium

Gavrilović, Ljubica; Popović, Nataša; Stojiljković, Vesna; Pejić, Snežana; Todorović, Ana; Vujović, Predrag; Pajović, Snežana B.

(2022)

TY  - JOUR
AU  - Gavrilović, Ljubica
AU  - Popović, Nataša
AU  - Stojiljković, Vesna
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Vujović, Predrag
AU  - Pajović, Snežana B.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10235
AB  - Background This study aimed to investigate the effects of lithium treatment on gene expression and activity of the prefrontal antioxidant enzymes: copper, zinc superoxide dismutase (SOD1), manganes superoxide dismutase (SOD2), catalase (CAT), and glutathione peroxidase (GPx) in animals exposed to chronic restraint stress (CRS). Methods The investigated parameters were quantified using real-time RT-PCR, Western blot analyses, and assays of enzyme activities. Results We found that lithium treatment decreased gene expression of SOD2, as well as the activities of SOD1 and SOD2 in chronically stressed rats to the levels found in unstressed animals. However, lithium treatment in animals exposed to CRS increased prefrontal GPx activity to the levels found in unstressed animals. Conclusions These findings confirm that treatment with lithium induced the modulation of prefrontal antioxidant status in chronically stressed rats. Our results may be very important in biomedical research for understanding the role of lithium in maintaining the stability of prefrontal antioxidant defense system in neuropsychiatric disorders caused by chronic stress.
T2  - PeerJ
T1  - Antioxidant defense system in the prefrontal cortex of chronically stressed rats treated with lithium
VL  - 10
SP  - e13020
DO  - 10.7717/peerj.13020
ER  - 
@article{
author = "Gavrilović, Ljubica and Popović, Nataša and Stojiljković, Vesna and Pejić, Snežana and Todorović, Ana and Vujović, Predrag and Pajović, Snežana B.",
year = "2022",
abstract = "Background This study aimed to investigate the effects of lithium treatment on gene expression and activity of the prefrontal antioxidant enzymes: copper, zinc superoxide dismutase (SOD1), manganes superoxide dismutase (SOD2), catalase (CAT), and glutathione peroxidase (GPx) in animals exposed to chronic restraint stress (CRS). Methods The investigated parameters were quantified using real-time RT-PCR, Western blot analyses, and assays of enzyme activities. Results We found that lithium treatment decreased gene expression of SOD2, as well as the activities of SOD1 and SOD2 in chronically stressed rats to the levels found in unstressed animals. However, lithium treatment in animals exposed to CRS increased prefrontal GPx activity to the levels found in unstressed animals. Conclusions These findings confirm that treatment with lithium induced the modulation of prefrontal antioxidant status in chronically stressed rats. Our results may be very important in biomedical research for understanding the role of lithium in maintaining the stability of prefrontal antioxidant defense system in neuropsychiatric disorders caused by chronic stress.",
journal = "PeerJ",
title = "Antioxidant defense system in the prefrontal cortex of chronically stressed rats treated with lithium",
volume = "10",
pages = "e13020",
doi = "10.7717/peerj.13020"
}
Gavrilović, L., Popović, N., Stojiljković, V., Pejić, S., Todorović, A., Vujović, P.,& Pajović, S. B.. (2022). Antioxidant defense system in the prefrontal cortex of chronically stressed rats treated with lithium. in PeerJ, 10, e13020.
https://doi.org/10.7717/peerj.13020
Gavrilović L, Popović N, Stojiljković V, Pejić S, Todorović A, Vujović P, Pajović SB. Antioxidant defense system in the prefrontal cortex of chronically stressed rats treated with lithium. in PeerJ. 2022;10:e13020.
doi:10.7717/peerj.13020 .
Gavrilović, Ljubica, Popović, Nataša, Stojiljković, Vesna, Pejić, Snežana, Todorović, Ana, Vujović, Predrag, Pajović, Snežana B., "Antioxidant defense system in the prefrontal cortex of chronically stressed rats treated with lithium" in PeerJ, 10 (2022):e13020,
https://doi.org/10.7717/peerj.13020 . .

Improvement of antibacterial activity of Ag-poly(vinyl-alcohol)/chitosan hydrogel by optimizing the procedure of radiolytic synthesis

Krstić, Jelena; Radosavljević, Aleksandra; Spasojević, Jelena; Nikolić, Nikolina; Jovanović, Uroš D.; Abazović, Nadica; Kačarević-Popović, Zorica

(2022)

TY  - JOUR
AU  - Krstić, Jelena
AU  - Radosavljević, Aleksandra
AU  - Spasojević, Jelena
AU  - Nikolić, Nikolina
AU  - Jovanović, Uroš D.
AU  - Abazović, Nadica
AU  - Kačarević-Popović, Zorica
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10183
AB  - Hydrogels consisting of radiation-degraded chitosan, poly(vinyl alcohol), and Ag nano-filler, were prepared by γ-irradiation in two-stage and single-stage procedures to examine the role of the synthesis procedure in improving the antibacterial activity. The light scattering method showed that radiation-degradation of chitosan occurred both by breaking the glucoside bonds and by Maillard's reaction. Elemental analysis indicated a reduction in the degree of deacetylation after degradation. The product of Amadori rearrangement and pigmented product melanoidins were determined by 1H NMR, FTIR, UV–Vis, and fluorescence spectroscopy. Enhancement of in vitro antibacterial activity of nanocomposites against Staphylococcus aureus and Escherichia coli was achieved by a single-stage procedure which results in greater mobility of radiation-modified chitosan in the network. This allows the exploitation of its potential, which is reflected in the possibility of the complexing of ultrasmall molecular Ag clusters. These complexes have a considerably stronger antibacterial effect. Ag in molecular form was confirmed by XPS analysis.
T2  - Radiation Physics and Chemistry
T1  - Improvement of antibacterial activity of Ag-poly(vinyl-alcohol)/chitosan hydrogel by optimizing the procedure of radiolytic synthesis
VL  - 194
SP  - 110045
DO  - 10.1016/j.radphyschem.2022.110045
ER  - 
@article{
author = "Krstić, Jelena and Radosavljević, Aleksandra and Spasojević, Jelena and Nikolić, Nikolina and Jovanović, Uroš D. and Abazović, Nadica and Kačarević-Popović, Zorica",
year = "2022",
abstract = "Hydrogels consisting of radiation-degraded chitosan, poly(vinyl alcohol), and Ag nano-filler, were prepared by γ-irradiation in two-stage and single-stage procedures to examine the role of the synthesis procedure in improving the antibacterial activity. The light scattering method showed that radiation-degradation of chitosan occurred both by breaking the glucoside bonds and by Maillard's reaction. Elemental analysis indicated a reduction in the degree of deacetylation after degradation. The product of Amadori rearrangement and pigmented product melanoidins were determined by 1H NMR, FTIR, UV–Vis, and fluorescence spectroscopy. Enhancement of in vitro antibacterial activity of nanocomposites against Staphylococcus aureus and Escherichia coli was achieved by a single-stage procedure which results in greater mobility of radiation-modified chitosan in the network. This allows the exploitation of its potential, which is reflected in the possibility of the complexing of ultrasmall molecular Ag clusters. These complexes have a considerably stronger antibacterial effect. Ag in molecular form was confirmed by XPS analysis.",
journal = "Radiation Physics and Chemistry",
title = "Improvement of antibacterial activity of Ag-poly(vinyl-alcohol)/chitosan hydrogel by optimizing the procedure of radiolytic synthesis",
volume = "194",
pages = "110045",
doi = "10.1016/j.radphyschem.2022.110045"
}
Krstić, J., Radosavljević, A., Spasojević, J., Nikolić, N., Jovanović, U. D., Abazović, N.,& Kačarević-Popović, Z.. (2022). Improvement of antibacterial activity of Ag-poly(vinyl-alcohol)/chitosan hydrogel by optimizing the procedure of radiolytic synthesis. in Radiation Physics and Chemistry, 194, 110045.
https://doi.org/10.1016/j.radphyschem.2022.110045
Krstić J, Radosavljević A, Spasojević J, Nikolić N, Jovanović UD, Abazović N, Kačarević-Popović Z. Improvement of antibacterial activity of Ag-poly(vinyl-alcohol)/chitosan hydrogel by optimizing the procedure of radiolytic synthesis. in Radiation Physics and Chemistry. 2022;194:110045.
doi:10.1016/j.radphyschem.2022.110045 .
Krstić, Jelena, Radosavljević, Aleksandra, Spasojević, Jelena, Nikolić, Nikolina, Jovanović, Uroš D., Abazović, Nadica, Kačarević-Popović, Zorica, "Improvement of antibacterial activity of Ag-poly(vinyl-alcohol)/chitosan hydrogel by optimizing the procedure of radiolytic synthesis" in Radiation Physics and Chemistry, 194 (2022):110045,
https://doi.org/10.1016/j.radphyschem.2022.110045 . .

Development and Validation of an Open-Source Finite-Volume Method Solver for Viscoplastic Flows

Mirkov, Nikola S.; Ouyahia, Seif Eddine; Lahlou, Sara; Pezo, Milada L.; Jovanović, Rastko D.

(2022)

TY  - CHAP
AU  - Mirkov, Nikola S.
AU  - Ouyahia, Seif Eddine
AU  - Lahlou, Sara
AU  - Pezo, Milada L.
AU  - Jovanović, Rastko D.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10065
AB  - In the present paper, we discuss implementation details of a free and open-source numerical solver based on the finite volume method for numerical simulation of viscoplastic non-Newtonian fluids. In addition to the fact that they are involved in many industrial applications, both their physical properties and their rheological behavior make them challenging for numerical simulation. Viscoplastic fluids are known to behave as solid unless the shear stress reaches a critical level, known as yield-stress, beyond which they behave as liquid. In most cases, both yielded and unyielded regions coexist in the fluid domain. In mathematical model of viscoplastic fluid, the constitutive equation is a non-differentiable function. This is often overcome by using the approximate constitutive equation that has a regularized form, e.g. the Papanastasiou regularization model. Using the same approach, we assess the influence of regularization parameters on simulation convergence and results accuracy. In this study, we give implementation details of viscoplastic fluid models in freeCappuccino open-source Computational Fluid Dynamics code. Moreover, we perform validation on several well known benchmark cases and compare proposed approach with those existing in published literature. We also perform a parametric analysis and show the effect of Reynolds and Bingham numbers on the extent of the yielded regions. Conclusions of the study have relevance in practical application of computational fluid dynamics to viscoplastic fluids in particular and to non-Newtonian fluids in general. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.
T2  - Lecture Notes in Networks and Systems
T1  - Development and Validation of an Open-Source Finite-Volume Method Solver for Viscoplastic Flows
VL  - 323
SP  - 223
EP  - 238
DO  - 10.1007/978-3-030-86009-7_12
ER  - 
@inbook{
author = "Mirkov, Nikola S. and Ouyahia, Seif Eddine and Lahlou, Sara and Pezo, Milada L. and Jovanović, Rastko D.",
year = "2022",
abstract = "In the present paper, we discuss implementation details of a free and open-source numerical solver based on the finite volume method for numerical simulation of viscoplastic non-Newtonian fluids. In addition to the fact that they are involved in many industrial applications, both their physical properties and their rheological behavior make them challenging for numerical simulation. Viscoplastic fluids are known to behave as solid unless the shear stress reaches a critical level, known as yield-stress, beyond which they behave as liquid. In most cases, both yielded and unyielded regions coexist in the fluid domain. In mathematical model of viscoplastic fluid, the constitutive equation is a non-differentiable function. This is often overcome by using the approximate constitutive equation that has a regularized form, e.g. the Papanastasiou regularization model. Using the same approach, we assess the influence of regularization parameters on simulation convergence and results accuracy. In this study, we give implementation details of viscoplastic fluid models in freeCappuccino open-source Computational Fluid Dynamics code. Moreover, we perform validation on several well known benchmark cases and compare proposed approach with those existing in published literature. We also perform a parametric analysis and show the effect of Reynolds and Bingham numbers on the extent of the yielded regions. Conclusions of the study have relevance in practical application of computational fluid dynamics to viscoplastic fluids in particular and to non-Newtonian fluids in general. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.",
journal = "Lecture Notes in Networks and Systems",
booktitle = "Development and Validation of an Open-Source Finite-Volume Method Solver for Viscoplastic Flows",
volume = "323",
pages = "223-238",
doi = "10.1007/978-3-030-86009-7_12"
}
Mirkov, N. S., Ouyahia, S. E., Lahlou, S., Pezo, M. L.,& Jovanović, R. D.. (2022). Development and Validation of an Open-Source Finite-Volume Method Solver for Viscoplastic Flows. in Lecture Notes in Networks and Systems, 323, 223-238.
https://doi.org/10.1007/978-3-030-86009-7_12
Mirkov NS, Ouyahia SE, Lahlou S, Pezo ML, Jovanović RD. Development and Validation of an Open-Source Finite-Volume Method Solver for Viscoplastic Flows. in Lecture Notes in Networks and Systems. 2022;323:223-238.
doi:10.1007/978-3-030-86009-7_12 .
Mirkov, Nikola S., Ouyahia, Seif Eddine, Lahlou, Sara, Pezo, Milada L., Jovanović, Rastko D., "Development and Validation of an Open-Source Finite-Volume Method Solver for Viscoplastic Flows" in Lecture Notes in Networks and Systems, 323 (2022):223-238,
https://doi.org/10.1007/978-3-030-86009-7_12 . .

Determination of the drag coefficient of lattice structures under wind load using porous media approach

Pezo, Milada L.; Mirkov, Nikola S.; Bakić, Vukman

(2022)

TY  - JOUR
AU  - Pezo, Milada L.
AU  - Mirkov, Nikola S.
AU  - Bakić, Vukman
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10176
AB  - The power transmitters, guyed masts and other lattice structures are exposed to wind action. The aerodynamic forces acting on tall tower constructions have crucial importance on the stability of the structure. The lattice structure drag coefficient determination is the subject of the international standards ESDU 81027 and 81028 and Eurocode 3 Part 3.1, but it can also be determined by numerical methods. For that purpose modelling using CFD proved to be both accurate and reliable. In this study the fluid-flow around the segment of a power transmitter was simulated by a 3-D model, where the geometry of the segment is approximated with a porous structure having the appropriate factor of porosity, in order to simplify the geometry. We have used three representative models of turbulence, standard k-? model, RNG k-? model, and Reynolds stress model. Drag coefficient values are extracted from the flow field and compared for all studied cases and with available experimental results from the wind tunnel. Simulations were performed for four wind velocities between 10 m/s and 30 m/s. The results are supplemented by the ones obtained by artificial neural network. The aim of this study is to show how the simple turbulence model coupled with approximated geometry can be used in the analysis of the aerodynamic forces acting on the lattice structure.
T2  - Thermal Science
T1  - Determination of the drag coefficient of lattice structures under wind load using porous media approach
VL  - 26
IS  - 1 Part A
SP  - 309
EP  - 317
DO  - 10.2298/TSCI210511233P
ER  - 
@article{
author = "Pezo, Milada L. and Mirkov, Nikola S. and Bakić, Vukman",
year = "2022",
abstract = "The power transmitters, guyed masts and other lattice structures are exposed to wind action. The aerodynamic forces acting on tall tower constructions have crucial importance on the stability of the structure. The lattice structure drag coefficient determination is the subject of the international standards ESDU 81027 and 81028 and Eurocode 3 Part 3.1, but it can also be determined by numerical methods. For that purpose modelling using CFD proved to be both accurate and reliable. In this study the fluid-flow around the segment of a power transmitter was simulated by a 3-D model, where the geometry of the segment is approximated with a porous structure having the appropriate factor of porosity, in order to simplify the geometry. We have used three representative models of turbulence, standard k-? model, RNG k-? model, and Reynolds stress model. Drag coefficient values are extracted from the flow field and compared for all studied cases and with available experimental results from the wind tunnel. Simulations were performed for four wind velocities between 10 m/s and 30 m/s. The results are supplemented by the ones obtained by artificial neural network. The aim of this study is to show how the simple turbulence model coupled with approximated geometry can be used in the analysis of the aerodynamic forces acting on the lattice structure.",
journal = "Thermal Science",
title = "Determination of the drag coefficient of lattice structures under wind load using porous media approach",
volume = "26",
number = "1 Part A",
pages = "309-317",
doi = "10.2298/TSCI210511233P"
}
Pezo, M. L., Mirkov, N. S.,& Bakić, V.. (2022). Determination of the drag coefficient of lattice structures under wind load using porous media approach. in Thermal Science, 26(1 Part A), 309-317.
https://doi.org/10.2298/TSCI210511233P
Pezo ML, Mirkov NS, Bakić V. Determination of the drag coefficient of lattice structures under wind load using porous media approach. in Thermal Science. 2022;26(1 Part A):309-317.
doi:10.2298/TSCI210511233P .
Pezo, Milada L., Mirkov, Nikola S., Bakić, Vukman, "Determination of the drag coefficient of lattice structures under wind load using porous media approach" in Thermal Science, 26, no. 1 Part A (2022):309-317,
https://doi.org/10.2298/TSCI210511233P . .

Influence of boron doping on characteristics of glucose-based hydrothermal carbons

Kalijadis, Ana; Maletić, Marina M.; Bjelajac, Anđelika Z.; Babić, Biljana M.; Minović Arsić, Tamara Z.; Vukčević, Marija M.

(2022)

TY  - JOUR
AU  - Kalijadis, Ana
AU  - Maletić, Marina M.
AU  - Bjelajac, Anđelika Z.
AU  - Babić, Biljana M.
AU  - Minović Arsić, Tamara Z.
AU  - Vukčević, Marija M.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10339
AB  - In this study, the influence of boron doping on structural and surface properties of carbon material synthesized by a hydrothermal method was investigated, and the obtained results were compared with the previously published influence that boron has on characteristics of carbonized boron-doped hydrothermal carbons (CHTCB). Hydrothermal carbons doped with boron (HTCB) were obtained by the hydrothermal synthesis of glucose solutions with different nominal concentrations of boric acid. It was found that glucose based hydrothermal carbon does not have developed porosity, and the presence of boron in their structure has insignificant influence on it. On the contrary, additional carbonization increases the specific surface area of the undoped sample, while an increase in boron content drastically decreases the specific surface area. Boron doping leads to a decrease in the amount of surface oxygen groups, for both, hydrothermally synthesized and additionally carbonized materials. Raman analysis showed that the boron content does not affect a structural arrangement of the HTCB samples, and Raman structural parameters show a higher degree of disorder, compared to the CHTCB samples. Comparison of structural and surface characteristics of hydrothermal carbons and carbonized materials contributes to the study of the so far, insufficiently clarified influence that boron incorporation has on the material characteristics. © 2022 Serbian Chemical Society. All rights reserved.
T2  - Journal of the Serbian Chemical Society
T1  - Influence of boron doping on characteristics of glucose-based hydrothermal carbons
VL  - 87
IS  - 6
SP  - 749
EP  - 760
DO  - 10.2298/JSC211011001K
ER  - 
@article{
author = "Kalijadis, Ana and Maletić, Marina M. and Bjelajac, Anđelika Z. and Babić, Biljana M. and Minović Arsić, Tamara Z. and Vukčević, Marija M.",
year = "2022",
abstract = "In this study, the influence of boron doping on structural and surface properties of carbon material synthesized by a hydrothermal method was investigated, and the obtained results were compared with the previously published influence that boron has on characteristics of carbonized boron-doped hydrothermal carbons (CHTCB). Hydrothermal carbons doped with boron (HTCB) were obtained by the hydrothermal synthesis of glucose solutions with different nominal concentrations of boric acid. It was found that glucose based hydrothermal carbon does not have developed porosity, and the presence of boron in their structure has insignificant influence on it. On the contrary, additional carbonization increases the specific surface area of the undoped sample, while an increase in boron content drastically decreases the specific surface area. Boron doping leads to a decrease in the amount of surface oxygen groups, for both, hydrothermally synthesized and additionally carbonized materials. Raman analysis showed that the boron content does not affect a structural arrangement of the HTCB samples, and Raman structural parameters show a higher degree of disorder, compared to the CHTCB samples. Comparison of structural and surface characteristics of hydrothermal carbons and carbonized materials contributes to the study of the so far, insufficiently clarified influence that boron incorporation has on the material characteristics. © 2022 Serbian Chemical Society. All rights reserved.",
journal = "Journal of the Serbian Chemical Society",
title = "Influence of boron doping on characteristics of glucose-based hydrothermal carbons",
volume = "87",
number = "6",
pages = "749-760",
doi = "10.2298/JSC211011001K"
}
Kalijadis, A., Maletić, M. M., Bjelajac, A. Z., Babić, B. M., Minović Arsić, T. Z.,& Vukčević, M. M.. (2022). Influence of boron doping on characteristics of glucose-based hydrothermal carbons. in Journal of the Serbian Chemical Society, 87(6), 749-760.
https://doi.org/10.2298/JSC211011001K
Kalijadis A, Maletić MM, Bjelajac AZ, Babić BM, Minović Arsić TZ, Vukčević MM. Influence of boron doping on characteristics of glucose-based hydrothermal carbons. in Journal of the Serbian Chemical Society. 2022;87(6):749-760.
doi:10.2298/JSC211011001K .
Kalijadis, Ana, Maletić, Marina M., Bjelajac, Anđelika Z., Babić, Biljana M., Minović Arsić, Tamara Z., Vukčević, Marija M., "Influence of boron doping on characteristics of glucose-based hydrothermal carbons" in Journal of the Serbian Chemical Society, 87, no. 6 (2022):749-760,
https://doi.org/10.2298/JSC211011001K . .

Impact properties of Kolon/PVB fabrics reinforced with rice-husk silica particles

Obradović, Vera; Vuksanović, Marija M.; Tomić, Nataša; Petrović, Miloš; Marinković, Aleksandar; Stojanović, Dušica; Radojević, Vesna; Jančić-Heinemann, Radmila; Uskoković, Petar

(2022)

TY  - JOUR
AU  - Obradović, Vera
AU  - Vuksanović, Marija M.
AU  - Tomić, Nataša
AU  - Petrović, Miloš
AU  - Marinković, Aleksandar
AU  - Stojanović, Dušica
AU  - Radojević, Vesna
AU  - Jančić-Heinemann, Radmila
AU  - Uskoković, Petar
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10337
AB  - This study presents the impact properties of the new form of hybrid thermoplastic composites. The Kolon fabrics were impregnated with the 10 wt% poly (vinyl butyral) (PVB)/ethanol solution with the addition of silica (SiO2) particles originating from rice husk or layered double hydroxide modified silica particles (FeAl-LDH@SiO2) as reinforcement. All the composites consisted of one layer of the impregnated fabric where the silica particles concentrations were 0.5 wt% and 1.0 wt% regarding PVB. The impact properties of the composite samples were analyzed by the controlled energy puncture impact tester. The structures of the composite samples were determined by the attenuated total reflection Fourier-transform infrared spectroscopy (ATR-FTIR) and field emission scanning electron microscopy (FE-SEM). The results showed that the Kolon/PVB/1 wt% FeAl-LDH@SiO2 sample yielded the maximum impact force.
T2  - Materials Letters
T1  - Impact properties of Kolon/PVB fabrics reinforced with rice-husk silica particles
VL  - 324
SP  - 132668
DO  - 10.1016/j.matlet.2022.132668
ER  - 
@article{
author = "Obradović, Vera and Vuksanović, Marija M. and Tomić, Nataša and Petrović, Miloš and Marinković, Aleksandar and Stojanović, Dušica and Radojević, Vesna and Jančić-Heinemann, Radmila and Uskoković, Petar",
year = "2022",
abstract = "This study presents the impact properties of the new form of hybrid thermoplastic composites. The Kolon fabrics were impregnated with the 10 wt% poly (vinyl butyral) (PVB)/ethanol solution with the addition of silica (SiO2) particles originating from rice husk or layered double hydroxide modified silica particles (FeAl-LDH@SiO2) as reinforcement. All the composites consisted of one layer of the impregnated fabric where the silica particles concentrations were 0.5 wt% and 1.0 wt% regarding PVB. The impact properties of the composite samples were analyzed by the controlled energy puncture impact tester. The structures of the composite samples were determined by the attenuated total reflection Fourier-transform infrared spectroscopy (ATR-FTIR) and field emission scanning electron microscopy (FE-SEM). The results showed that the Kolon/PVB/1 wt% FeAl-LDH@SiO2 sample yielded the maximum impact force.",
journal = "Materials Letters",
title = "Impact properties of Kolon/PVB fabrics reinforced with rice-husk silica particles",
volume = "324",
pages = "132668",
doi = "10.1016/j.matlet.2022.132668"
}
Obradović, V., Vuksanović, M. M., Tomić, N., Petrović, M., Marinković, A., Stojanović, D., Radojević, V., Jančić-Heinemann, R.,& Uskoković, P.. (2022). Impact properties of Kolon/PVB fabrics reinforced with rice-husk silica particles. in Materials Letters, 324, 132668.
https://doi.org/10.1016/j.matlet.2022.132668
Obradović V, Vuksanović MM, Tomić N, Petrović M, Marinković A, Stojanović D, Radojević V, Jančić-Heinemann R, Uskoković P. Impact properties of Kolon/PVB fabrics reinforced with rice-husk silica particles. in Materials Letters. 2022;324:132668.
doi:10.1016/j.matlet.2022.132668 .
Obradović, Vera, Vuksanović, Marija M., Tomić, Nataša, Petrović, Miloš, Marinković, Aleksandar, Stojanović, Dušica, Radojević, Vesna, Jančić-Heinemann, Radmila, Uskoković, Petar, "Impact properties of Kolon/PVB fabrics reinforced with rice-husk silica particles" in Materials Letters, 324 (2022):132668,
https://doi.org/10.1016/j.matlet.2022.132668 . .