TY  - JOUR
AU  - Milovanović, Stoja
AU  - Marković, Darka
AU  - Mraković, Ana Đ.
AU  - Kuska, Robert
AU  - Žižović, Irena T.
AU  - Frerich, Sulamith
AU  - Ivanović, Jasna
PY  - 2019
UR  - https://linkinghub.elsevier.com/retrieve/pii/S0928493117342169
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8041
AB  - Amorphous, medical grade poly(D,L-lactic acid) (PLA) and poly(D,L-lactic-co-glycolic acid) (PLGA) were used to develop systems for controlled release of a natural bioactive substance - thymol. Supercritical carbon dioxide (scCO2) was successfully used both as an impregnation medium for thymol incorporation into the polymer matrix and a foaming agent in a single-step batch process. Impregnation of samples using low to moderate scCO2 densities (273 kg/m3 and 630 kg/m3) and short processing times (2 h and 4 h) enabled thymol loading of 0.92%–6.62% and formation of microcellular foams upon system depressurization. Thymol effect on structural and thermal properties on foamed samples was proven by FTIR and DSC. The effect of CO2 under elevated pressure on the neat polymers was analysed by high pressure DSC. Foaming of polymers with lower molecular weight by CO2 of higher density yielded foams with smaller pores. All tested foams released thymol in a controlled manner in phosphate buffered saline (PBS) at 37 °C within 3 to 6 weeks. Higher loading and lower cell density favoured thymol release rate, while its concentration in PBS for the tested period depended on foam interaction with the medium. Representative PLGA foam sample with the highest thymol loading (6.62%) showed controlled thymol release within 72 h in mediums having pH values from 1.1 to 7.4. © 2019 Elsevier B.V.
T2  - Materials Science and Engineering: C
T1  - Supercritical CO2 - assisted production of PLA and PLGA foams for controlled thymol release
VL  - 99
SP  - 394
EP  - 404
DO  - 10.1016/j.msec.2019.01.106
ER  - 

@article{
author = "Milovanović, Stoja and Marković, Darka and Mraković, Ana Đ. and Kuska, Robert and Žižović, Irena T. and Frerich, Sulamith and Ivanović, Jasna",
year = "2019",
abstract = "Amorphous, medical grade poly(D,L-lactic acid) (PLA) and poly(D,L-lactic-co-glycolic acid) (PLGA) were used to develop systems for controlled release of a natural bioactive substance - thymol. Supercritical carbon dioxide (scCO2) was successfully used both as an impregnation medium for thymol incorporation into the polymer matrix and a foaming agent in a single-step batch process. Impregnation of samples using low to moderate scCO2 densities (273 kg/m3 and 630 kg/m3) and short processing times (2 h and 4 h) enabled thymol loading of 0.92%–6.62% and formation of microcellular foams upon system depressurization. Thymol effect on structural and thermal properties on foamed samples was proven by FTIR and DSC. The effect of CO2 under elevated pressure on the neat polymers was analysed by high pressure DSC. Foaming of polymers with lower molecular weight by CO2 of higher density yielded foams with smaller pores. All tested foams released thymol in a controlled manner in phosphate buffered saline (PBS) at 37 °C within 3 to 6 weeks. Higher loading and lower cell density favoured thymol release rate, while its concentration in PBS for the tested period depended on foam interaction with the medium. Representative PLGA foam sample with the highest thymol loading (6.62%) showed controlled thymol release within 72 h in mediums having pH values from 1.1 to 7.4. © 2019 Elsevier B.V.",
journal = "Materials Science and Engineering: C",
title = "Supercritical CO2 - assisted production of PLA and PLGA foams for controlled thymol release",
volume = "99",
pages = "394-404",
doi = "10.1016/j.msec.2019.01.106"
}

Milovanović, S., Marković, D., Mraković, A. Đ., Kuska, R., Žižović, I. T., Frerich, S.,& Ivanović, J.. (2019). Supercritical CO2 - assisted production of PLA and PLGA foams for controlled thymol release. in Materials Science and Engineering: C, 99, 394-404.
https://doi.org/10.1016/j.msec.2019.01.106

Milovanović S, Marković D, Mraković AĐ, Kuska R, Žižović IT, Frerich S, Ivanović J. Supercritical CO2 - assisted production of PLA and PLGA foams for controlled thymol release. in Materials Science and Engineering: C. 2019;99:394-404.
doi:10.1016/j.msec.2019.01.106 .

Milovanović, Stoja, Marković, Darka, Mraković, Ana Đ., Kuska, Robert, Žižović, Irena T., Frerich, Sulamith, Ivanović, Jasna, "Supercritical CO2 - assisted production of PLA and PLGA foams for controlled thymol release" in Materials Science and Engineering: C, 99 (2019):394-404,
https://doi.org/10.1016/j.msec.2019.01.106 . .

TY  - JOUR
AU  - Radović, Marko
AU  - Adamović, Tijana
AU  - Pavlović, Jelena
AU  - Rusmirović, Jelena
AU  - Tadić, Vanja
AU  - Branković, Zorica
AU  - Ivanović, Jasna
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8438
AB  - Supercritical CO2 impregnation process was used for the first time to fabricate biodegradable gelatin-chitosan (G/Ch) films containing clove oil (CO) for potential use in active food packaging. All the impregnations were carried out at moderately low temperature (40 °C). Aiming to maximize CO loading in the films with acceptable morphological, structural and thermal properties, CO2 pressure, impregnation time and G:Ch mass ratio were varied. Gelatin fraction in the films of 25-50 wt.%, scCO2 pressures of 10-20 MPa and impregnation time of 2-6 h impregnation favoured the CO loading. Processing of the film with equal gelatin to chitosan mass ratio (G/Ch50:50) at 10 MPa for 2 h yielded sufficiently high loading (56 mg CO/gfilm) without an adverse effect on morphological properties. The G/Ch50:50 film was therefore chosen for structural and thermal analyses. ATR-FTIR analysis confirmed successful CO incorporation into the G/Ch50:50 and its interaction with the film. Plasticizing effect of scCO2 and CO on the film was evidenced by DSC. Incorporation of 56 mg CO/gfilm into the G/Ch50:50 didn't affect thermal stability of the film. Beside environmental benefits, supercritical impregnation process enables fast fabrication of G/Ch bio-composite films containing CO, thermally stable to 110 °C, which is suitable for most of food packaging applications. © 2019, CI and CEQ. All rights reserved.
T2  - Chemical Industry and Chemical Engineering Quarterly / CICEQ
T1  - Supercritical CO2 impregnation of Gelatin-Chitosan films with clove essential oil and characterization thereof
VL  - 25
IS  - 2
SP  - 119
EP  - 130
DO  - 10.2298/CICEQ180323025R
ER  - 

@article{
author = "Radović, Marko and Adamović, Tijana and Pavlović, Jelena and Rusmirović, Jelena and Tadić, Vanja and Branković, Zorica and Ivanović, Jasna",
year = "2019",
abstract = "Supercritical CO2 impregnation process was used for the first time to fabricate biodegradable gelatin-chitosan (G/Ch) films containing clove oil (CO) for potential use in active food packaging. All the impregnations were carried out at moderately low temperature (40 °C). Aiming to maximize CO loading in the films with acceptable morphological, structural and thermal properties, CO2 pressure, impregnation time and G:Ch mass ratio were varied. Gelatin fraction in the films of 25-50 wt.%, scCO2 pressures of 10-20 MPa and impregnation time of 2-6 h impregnation favoured the CO loading. Processing of the film with equal gelatin to chitosan mass ratio (G/Ch50:50) at 10 MPa for 2 h yielded sufficiently high loading (56 mg CO/gfilm) without an adverse effect on morphological properties. The G/Ch50:50 film was therefore chosen for structural and thermal analyses. ATR-FTIR analysis confirmed successful CO incorporation into the G/Ch50:50 and its interaction with the film. Plasticizing effect of scCO2 and CO on the film was evidenced by DSC. Incorporation of 56 mg CO/gfilm into the G/Ch50:50 didn't affect thermal stability of the film. Beside environmental benefits, supercritical impregnation process enables fast fabrication of G/Ch bio-composite films containing CO, thermally stable to 110 °C, which is suitable for most of food packaging applications. © 2019, CI and CEQ. All rights reserved.",
journal = "Chemical Industry and Chemical Engineering Quarterly / CICEQ",
title = "Supercritical CO2 impregnation of Gelatin-Chitosan films with clove essential oil and characterization thereof",
volume = "25",
number = "2",
pages = "119-130",
doi = "10.2298/CICEQ180323025R"
}

Radović, M., Adamović, T., Pavlović, J., Rusmirović, J., Tadić, V., Branković, Z.,& Ivanović, J.. (2019). Supercritical CO2 impregnation of Gelatin-Chitosan films with clove essential oil and characterization thereof. in Chemical Industry and Chemical Engineering Quarterly / CICEQ, 25(2), 119-130.
https://doi.org/10.2298/CICEQ180323025R

Radović M, Adamović T, Pavlović J, Rusmirović J, Tadić V, Branković Z, Ivanović J. Supercritical CO2 impregnation of Gelatin-Chitosan films with clove essential oil and characterization thereof. in Chemical Industry and Chemical Engineering Quarterly / CICEQ. 2019;25(2):119-130.
doi:10.2298/CICEQ180323025R .

Radović, Marko, Adamović, Tijana, Pavlović, Jelena, Rusmirović, Jelena, Tadić, Vanja, Branković, Zorica, Ivanović, Jasna, "Supercritical CO2 impregnation of Gelatin-Chitosan films with clove essential oil and characterization thereof" in Chemical Industry and Chemical Engineering Quarterly / CICEQ, 25, no. 2 (2019):119-130,
https://doi.org/10.2298/CICEQ180323025R . .

TY  - JOUR
AU  - Brašanac-Vukanović, Snežana
AU  - Mutić, Jelena J.
AU  - Stanković, Dalibor M.
AU  - Arsić, Ivana A.
AU  - Blagojević, Nada Z.
AU  - Vukašinović-Pešić, Vesna L.
AU  - Tadić, Vanja M.
PY  - 2018
UR  - http://www.mdpi.com/1420-3049/23/8/1864
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7848
AB  - The aim of this study was to establish correlation of chemical composition and antioxidant activity of bilberry plants from Montenegro. Total phenolic, tannin, flavonoid, procyanidin and anthocyanin contents were determined in fruits and leaves extracts using spectrophotometric methods, while the measurements of metal content was carried out in an Inductively Coupled Atomic Emission Spectrometer. Qualitative and quantitative analyses of major phenolics were achieved by HPLC. In the investigated extracts, the most abundant phenolic was chlorogenic acid, followed by protocatechuic acid, while resveratrol, isoquercetin, quecetin and hyperoside were also present in significant quantities. Antioxidant potential was evaluated using two in vitro assays—FRAP and DPPH—being in the accordance with the cyclic voltammetry tests, performed as well. The results revealed that all the investigated extracts were rich in phenolic and essential mineral constituents, with significant antioxidant activity, depending on the polyphenolic and mineral contents, which was confirmed by principal component analysis.
T2  - Molecules
T1  - Wild Bilberry (Vaccinium myrtillus L., Ericaceae) from Montenegro as a Source of Antioxidants for Use in the Production of Nutraceuticals
VL  - 23
IS  - 8
SP  - 1864
DO  - 10.3390/molecules23081864
ER  - 

@article{
author = "Brašanac-Vukanović, Snežana and Mutić, Jelena J. and Stanković, Dalibor M. and Arsić, Ivana A. and Blagojević, Nada Z. and Vukašinović-Pešić, Vesna L. and Tadić, Vanja M.",
year = "2018",
abstract = "The aim of this study was to establish correlation of chemical composition and antioxidant activity of bilberry plants from Montenegro. Total phenolic, tannin, flavonoid, procyanidin and anthocyanin contents were determined in fruits and leaves extracts using spectrophotometric methods, while the measurements of metal content was carried out in an Inductively Coupled Atomic Emission Spectrometer. Qualitative and quantitative analyses of major phenolics were achieved by HPLC. In the investigated extracts, the most abundant phenolic was chlorogenic acid, followed by protocatechuic acid, while resveratrol, isoquercetin, quecetin and hyperoside were also present in significant quantities. Antioxidant potential was evaluated using two in vitro assays—FRAP and DPPH—being in the accordance with the cyclic voltammetry tests, performed as well. The results revealed that all the investigated extracts were rich in phenolic and essential mineral constituents, with significant antioxidant activity, depending on the polyphenolic and mineral contents, which was confirmed by principal component analysis.",
journal = "Molecules",
title = "Wild Bilberry (Vaccinium myrtillus L., Ericaceae) from Montenegro as a Source of Antioxidants for Use in the Production of Nutraceuticals",
volume = "23",
number = "8",
pages = "1864",
doi = "10.3390/molecules23081864"
}

Brašanac-Vukanović, S., Mutić, J. J., Stanković, D. M., Arsić, I. A., Blagojević, N. Z., Vukašinović-Pešić, V. L.,& Tadić, V. M.. (2018). Wild Bilberry (Vaccinium myrtillus L., Ericaceae) from Montenegro as a Source of Antioxidants for Use in the Production of Nutraceuticals. in Molecules, 23(8), 1864.
https://doi.org/10.3390/molecules23081864

Brašanac-Vukanović S, Mutić JJ, Stanković DM, Arsić IA, Blagojević NZ, Vukašinović-Pešić VL, Tadić VM. Wild Bilberry (Vaccinium myrtillus L., Ericaceae) from Montenegro as a Source of Antioxidants for Use in the Production of Nutraceuticals. in Molecules. 2018;23(8):1864.
doi:10.3390/molecules23081864 .

Brašanac-Vukanović, Snežana, Mutić, Jelena J., Stanković, Dalibor M., Arsić, Ivana A., Blagojević, Nada Z., Vukašinović-Pešić, Vesna L., Tadić, Vanja M., "Wild Bilberry (Vaccinium myrtillus L., Ericaceae) from Montenegro as a Source of Antioxidants for Use in the Production of Nutraceuticals" in Molecules, 23, no. 8 (2018):1864,
https://doi.org/10.3390/molecules23081864 . .