TY  - JOUR
AU  - Nićiforović, Ana
AU  - Adžić, Miroslav
AU  - Spasić, Snežana D.
AU  - Radojčić, Marija
PY  - 2007
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3353
AB  - The anti proliferative and cytotoxic potential of the natural anthracycline aloin from Aloe vera was tested on human uterine carcinoma HeLaS3 cells. Aloin showed a pronounced antiproliferative effect at physiological concentration (IC50 =97 mu M), caused cell cycle arrest in the S phase and markedly increased HeLaS3 cell apoptosis (to 24%). In the concentration range of 20-100 mu M, its action was accompanied by remarkable changes in the activity of almost all antioxidant enzymes: MnSOD activity was increased many fold, while CuZnSOD and iNOS activities were inhibited. Moreover, inhibition of CuZnSOD was shown to occur by direct aloin interaction with the enzyme. As catalase activity was not changed, it is suggested that such conditions were responsible for antiproliferative and cytotoxic effects owing to accumulation of H2O2. Aloin alone was a more potent proapoptotic agent than a 2 Gy fractional dose of ionizing radiation or a combination of the two. Compared to other currently used therapeutics, aloin, due to its less undesirable side effects and antimetastatic potential, may prove to be the agent of choice on which clinical protocols for the treatment of human cervical carcinoma should rely in future.
T2  - Cancer Biology and Therapy
T1  - Antitumor effects of a natural anthracycline analog (Aloin) involve altered activity of antioxidant enzymes in HeLaS3 cells
VL  - 6
IS  - 8
SP  - 1200
EP  - 1205
DO  - 10.4161/cbt.6.8.4383
UR  - https://hdl.handle.net/21.15107/rcub_vinar_3353
ER  - 

@article{
author = "Nićiforović, Ana and Adžić, Miroslav and Spasić, Snežana D. and Radojčić, Marija",
year = "2007",
abstract = "The anti proliferative and cytotoxic potential of the natural anthracycline aloin from Aloe vera was tested on human uterine carcinoma HeLaS3 cells. Aloin showed a pronounced antiproliferative effect at physiological concentration (IC50 =97 mu M), caused cell cycle arrest in the S phase and markedly increased HeLaS3 cell apoptosis (to 24%). In the concentration range of 20-100 mu M, its action was accompanied by remarkable changes in the activity of almost all antioxidant enzymes: MnSOD activity was increased many fold, while CuZnSOD and iNOS activities were inhibited. Moreover, inhibition of CuZnSOD was shown to occur by direct aloin interaction with the enzyme. As catalase activity was not changed, it is suggested that such conditions were responsible for antiproliferative and cytotoxic effects owing to accumulation of H2O2. Aloin alone was a more potent proapoptotic agent than a 2 Gy fractional dose of ionizing radiation or a combination of the two. Compared to other currently used therapeutics, aloin, due to its less undesirable side effects and antimetastatic potential, may prove to be the agent of choice on which clinical protocols for the treatment of human cervical carcinoma should rely in future.",
journal = "Cancer Biology and Therapy",
title = "Antitumor effects of a natural anthracycline analog (Aloin) involve altered activity of antioxidant enzymes in HeLaS3 cells",
volume = "6",
number = "8",
pages = "1200-1205",
doi = "10.4161/cbt.6.8.4383",
url = "https://hdl.handle.net/21.15107/rcub_vinar_3353"
}

Nićiforović, A., Adžić, M., Spasić, S. D.,& Radojčić, M.. (2007). Antitumor effects of a natural anthracycline analog (Aloin) involve altered activity of antioxidant enzymes in HeLaS3 cells. in Cancer Biology and Therapy, 6(8), 1200-1205.
https://doi.org/10.4161/cbt.6.8.4383
https://hdl.handle.net/21.15107/rcub_vinar_3353

Nićiforović A, Adžić M, Spasić SD, Radojčić M. Antitumor effects of a natural anthracycline analog (Aloin) involve altered activity of antioxidant enzymes in HeLaS3 cells. in Cancer Biology and Therapy. 2007;6(8):1200-1205.
doi:10.4161/cbt.6.8.4383
https://hdl.handle.net/21.15107/rcub_vinar_3353 .

Nićiforović, Ana, Adžić, Miroslav, Spasić, Snežana D., Radojčić, Marija, "Antitumor effects of a natural anthracycline analog (Aloin) involve altered activity of antioxidant enzymes in HeLaS3 cells" in Cancer Biology and Therapy, 6, no. 8 (2007):1200-1205,
https://doi.org/10.4161/cbt.6.8.4383 .,
https://hdl.handle.net/21.15107/rcub_vinar_3353 .