TY  - JOUR
AU  - Petrović, Voin
AU  - Petrović, Sandra
AU  - Joksić, Gordana
AU  - Savić, Jasmina
AU  - Čolović, Mirjana B.
AU  - Cinellu, Maria Agostina
AU  - Massai, Lara
AU  - Messori, Luigi
AU  - Vasić, Vesna M.
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/140
AB  - Na+/K+-ATPase is in charge of maintaining the ionic and osmotic intracellular balance by using ATP as an energy source to drive excess Na+ ions out of the cell in exchange for K+ ions. We explored whether three representative cytotoxic gold(III) compounds might interfere with Na+/K+-ATPase and cause its inhibition at pharmacologically relevant concentrations. The tested complexes were [Au(bipy)(OH)(2)][PF6] (bipy = 2,2-bipyridine), [Au (py(dmb)-H)(CH3COO)(2)] (py(dmb)-H = deprotonated 6-(1,1-dimethylbenzyl)-pyridine), and [Au(bipy(dmb)-H)(OH)][PF6] (bipy(dmb)-H = deprotonated 6-(1,1-dimethylbenzyl)-2,2-bipyridine). We found that all of them caused a pronounced and similar inhibition of Na+/K+-ATPase activity. Inhibition was found to be non-competitive and reversible. Remarkably, treatment with cysteine resulted in reversal or prevention of Na+/K+-ATPase inhibition. It is very likely that the described effects may contribute to the overall cytotoxic profile of these gold complexes. (C) 2014 Elsevier Inc. All rights reserved.
T2  - Journal of Inorganic Biochemistry
T1  - Inhibition of Na+/K+-ATPase and cytotoxicity of a few selected gold(III) complexes
VL  - 140
SP  - 228
EP  - 235
DO  - 10.1016/j.jinorgbio.2014.07.015
ER  - 

@article{
author = "Petrović, Voin and Petrović, Sandra and Joksić, Gordana and Savić, Jasmina and Čolović, Mirjana B. and Cinellu, Maria Agostina and Massai, Lara and Messori, Luigi and Vasić, Vesna M.",
year = "2014",
abstract = "Na+/K+-ATPase is in charge of maintaining the ionic and osmotic intracellular balance by using ATP as an energy source to drive excess Na+ ions out of the cell in exchange for K+ ions. We explored whether three representative cytotoxic gold(III) compounds might interfere with Na+/K+-ATPase and cause its inhibition at pharmacologically relevant concentrations. The tested complexes were [Au(bipy)(OH)(2)][PF6] (bipy = 2,2-bipyridine), [Au (py(dmb)-H)(CH3COO)(2)] (py(dmb)-H = deprotonated 6-(1,1-dimethylbenzyl)-pyridine), and [Au(bipy(dmb)-H)(OH)][PF6] (bipy(dmb)-H = deprotonated 6-(1,1-dimethylbenzyl)-2,2-bipyridine). We found that all of them caused a pronounced and similar inhibition of Na+/K+-ATPase activity. Inhibition was found to be non-competitive and reversible. Remarkably, treatment with cysteine resulted in reversal or prevention of Na+/K+-ATPase inhibition. It is very likely that the described effects may contribute to the overall cytotoxic profile of these gold complexes. (C) 2014 Elsevier Inc. All rights reserved.",
journal = "Journal of Inorganic Biochemistry",
title = "Inhibition of Na+/K+-ATPase and cytotoxicity of a few selected gold(III) complexes",
volume = "140",
pages = "228-235",
doi = "10.1016/j.jinorgbio.2014.07.015"
}

Petrović, V., Petrović, S., Joksić, G., Savić, J., Čolović, M. B., Cinellu, M. A., Massai, L., Messori, L.,& Vasić, V. M.. (2014). Inhibition of Na+/K+-ATPase and cytotoxicity of a few selected gold(III) complexes. in Journal of Inorganic Biochemistry, 140, 228-235.
https://doi.org/10.1016/j.jinorgbio.2014.07.015

Petrović V, Petrović S, Joksić G, Savić J, Čolović MB, Cinellu MA, Massai L, Messori L, Vasić VM. Inhibition of Na+/K+-ATPase and cytotoxicity of a few selected gold(III) complexes. in Journal of Inorganic Biochemistry. 2014;140:228-235.
doi:10.1016/j.jinorgbio.2014.07.015 .

Petrović, Voin, Petrović, Sandra, Joksić, Gordana, Savić, Jasmina, Čolović, Mirjana B., Cinellu, Maria Agostina, Massai, Lara, Messori, Luigi, Vasić, Vesna M., "Inhibition of Na+/K+-ATPase and cytotoxicity of a few selected gold(III) complexes" in Journal of Inorganic Biochemistry, 140 (2014):228-235,
https://doi.org/10.1016/j.jinorgbio.2014.07.015 . .