TY  - JOUR
AU  - Jokić, Bojan M.
AU  - Mitrić, Miodrag
AU  - Popović, Maja
AU  - Sima, L.
AU  - Petrescu, S. M.
AU  - Petrović, R.
AU  - Janaćković, Đorđe T.
PY  - 2011
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4518
AB  - In this work, the influence of the morphology of hydroxyapatite particles on silicon substitution through hydrothermal synthesis performed under the same conditions was investigated. Spherical- and whisker-like hydroxyapatite particles were obtained starting from calcium-nitrate, sodium dihydrogen phosphate, disodium-ethylenediaminetetraacetic acid and urea (used only for the synthesis of whisker-like particles) dissolved in aqueous solutions. Silicon was introduced into the solution using tetraethylorthosilicate. X-ray diffraction, infrared spectroscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy and transmission electron microscopy indicate that silicon doping induce different phase compositions and bioactivity of spherical- and whisker-like hydroxyapatite particles obtained under the same hydrothermal conditions. Silicon-substituted, spherical hydroxyapatites particles showed greater phase transformation to silicon-substituted alpha- calcium-phosphate compared with whiskers-like hydroxyapatite particles synthesized with the same amount of added silicon. Metabolic activity assay performed with SaOs2 osteosarcoma cells showed better biocompatibility of annealed biphasic spherical-like particles compared with annealed whiskerlike particles while dried spherical-like particles induce high cytotoxicity effect.
T2  - Journal of Materials Science: Materials in Medicine
T1  - The influence of silicon substitution on the properties of spherical- and whisker-like biphasic alpha-calcium-phosphate/hydroxyapatite particles
VL  - 22
IS  - 10
SP  - 2175
EP  - 2185
DO  - 10.1007/s10856-011-4412-6
ER  - 

@article{
author = "Jokić, Bojan M. and Mitrić, Miodrag and Popović, Maja and Sima, L. and Petrescu, S. M. and Petrović, R. and Janaćković, Đorđe T.",
year = "2011",
abstract = "In this work, the influence of the morphology of hydroxyapatite particles on silicon substitution through hydrothermal synthesis performed under the same conditions was investigated. Spherical- and whisker-like hydroxyapatite particles were obtained starting from calcium-nitrate, sodium dihydrogen phosphate, disodium-ethylenediaminetetraacetic acid and urea (used only for the synthesis of whisker-like particles) dissolved in aqueous solutions. Silicon was introduced into the solution using tetraethylorthosilicate. X-ray diffraction, infrared spectroscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy and transmission electron microscopy indicate that silicon doping induce different phase compositions and bioactivity of spherical- and whisker-like hydroxyapatite particles obtained under the same hydrothermal conditions. Silicon-substituted, spherical hydroxyapatites particles showed greater phase transformation to silicon-substituted alpha- calcium-phosphate compared with whiskers-like hydroxyapatite particles synthesized with the same amount of added silicon. Metabolic activity assay performed with SaOs2 osteosarcoma cells showed better biocompatibility of annealed biphasic spherical-like particles compared with annealed whiskerlike particles while dried spherical-like particles induce high cytotoxicity effect.",
journal = "Journal of Materials Science: Materials in Medicine",
title = "The influence of silicon substitution on the properties of spherical- and whisker-like biphasic alpha-calcium-phosphate/hydroxyapatite particles",
volume = "22",
number = "10",
pages = "2175-2185",
doi = "10.1007/s10856-011-4412-6"
}

Jokić, B. M., Mitrić, M., Popović, M., Sima, L., Petrescu, S. M., Petrović, R.,& Janaćković, Đ. T.. (2011). The influence of silicon substitution on the properties of spherical- and whisker-like biphasic alpha-calcium-phosphate/hydroxyapatite particles. in Journal of Materials Science: Materials in Medicine, 22(10), 2175-2185.
https://doi.org/10.1007/s10856-011-4412-6

Jokić BM, Mitrić M, Popović M, Sima L, Petrescu SM, Petrović R, Janaćković ĐT. The influence of silicon substitution on the properties of spherical- and whisker-like biphasic alpha-calcium-phosphate/hydroxyapatite particles. in Journal of Materials Science: Materials in Medicine. 2011;22(10):2175-2185.
doi:10.1007/s10856-011-4412-6 .

Jokić, Bojan M., Mitrić, Miodrag, Popović, Maja, Sima, L., Petrescu, S. M., Petrović, R., Janaćković, Đorđe T., "The influence of silicon substitution on the properties of spherical- and whisker-like biphasic alpha-calcium-phosphate/hydroxyapatite particles" in Journal of Materials Science: Materials in Medicine, 22, no. 10 (2011):2175-2185,
https://doi.org/10.1007/s10856-011-4412-6 . .