TY  - JOUR
AU  - Vučina, Jurij L.
AU  - Lukić, Dragoljub M.
PY  - 2002
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10145
AB  - The paper deals with production and application of open radioactive sources in modern diagnostic and therapeutic nuclear medicine. In principle, besides adequate physical, chemical and biological properties a reliable route for the routine production of both radionuclide and radiopharmaceutical should be on disposal. The favorite route are radionuclidic generators as they enable simple production of shorter-lived radionuclides at relatively low costs. The main radionuclide in diagnosis is technetium-99m. Its advantages are favorable nuclear properties, availability of large activities of high quality 99m Tc at reasonable prices by using (n,f)99Mo/ 99m Tc generators and versatile chemistry. It is used in the investigation of practically all organs and tissues in the human body. Among the beta- emitters the radionuclides of rhenium have been recently proposed as suitable candidates for therapeutic applications. The most important is 188Re which is obtained from 188W/ 188Re generator. Some of the important radiopharmaceuticals labeled with rhenium radionuclides used for certain specific indications are also shown. The activities performed in the Laboratory for Radioisotopes (Vinča Institute of Nuclear Sciences) are also enclosed.
AB  - Prikazani su neki od najvažnijih aspekata proizvodnje i primene otvorenih izvora radioaktivnog zračenja u dijagnostičkoj i terapijskoj nuklearnoj medicini. Pored fizičkih, bitne su i hemijske i biohemijske osobine datog radionuklida odnosno radiofarmaceutika. Uslov za redovnu primenu su i dostupnost, kvalitet i cena. Radionuklidni generatori predstavljaju vrlo pogodan izvor dobijanja radionuklida kraćih vremena poluraspada. Najvažniji dijagnostički radionuklid je 99m Tc. Odlične fizičke osobine, visok kvalitet i laka dostupnost po prihvatljivim cenama korišćenjem molibden-99/tehnecijum- 99m generatora i razvijena hemija doveli su do toga da ovaj radionuklid postane praktično nezamenjiv u ispitivanju skoro svih organa i tkiva u ljudskom organizmu. Dati su savremeni trendovi u razvoju proizvodnje radionuklida i radiofarmaceutika za primenu u terapijske svrhe. Prikazani su načini dobijanja radionuklida renijuma (186Re i 188Re) sa posebnim naglaskom na 188W/ 188Re generatoru. Dati su hemijski oblici i indikacije za primenu nekih radioaktivnih lekova obeleženih ovim radionuklidima. Prikazana su istraživanja sprovedena u Laboratoriji za radioizotope (Institut za nuklearne nauke «Vinča»).
T2  - Facta Universitatis, Series: Physics, Chemistry and Technology
T1  - Radionuclidic generators for the production of technetium-99m and rhenium-188
T1  - Radionuklidni generatori za dobijanje tehnecijuma-99m i renijuma-188
VL  - 2
IS  - 4
SP  - 235
EP  - 243
DO  - 10.2298/FUPCT0204235V
ER  - 

@article{
author = "Vučina, Jurij L. and Lukić, Dragoljub M.",
year = "2002",
abstract = "The paper deals with production and application of open radioactive sources in modern diagnostic and therapeutic nuclear medicine. In principle, besides adequate physical, chemical and biological properties a reliable route for the routine production of both radionuclide and radiopharmaceutical should be on disposal. The favorite route are radionuclidic generators as they enable simple production of shorter-lived radionuclides at relatively low costs. The main radionuclide in diagnosis is technetium-99m. Its advantages are favorable nuclear properties, availability of large activities of high quality 99m Tc at reasonable prices by using (n,f)99Mo/ 99m Tc generators and versatile chemistry. It is used in the investigation of practically all organs and tissues in the human body. Among the beta- emitters the radionuclides of rhenium have been recently proposed as suitable candidates for therapeutic applications. The most important is 188Re which is obtained from 188W/ 188Re generator. Some of the important radiopharmaceuticals labeled with rhenium radionuclides used for certain specific indications are also shown. The activities performed in the Laboratory for Radioisotopes (Vinča Institute of Nuclear Sciences) are also enclosed., Prikazani su neki od najvažnijih aspekata proizvodnje i primene otvorenih izvora radioaktivnog zračenja u dijagnostičkoj i terapijskoj nuklearnoj medicini. Pored fizičkih, bitne su i hemijske i biohemijske osobine datog radionuklida odnosno radiofarmaceutika. Uslov za redovnu primenu su i dostupnost, kvalitet i cena. Radionuklidni generatori predstavljaju vrlo pogodan izvor dobijanja radionuklida kraćih vremena poluraspada. Najvažniji dijagnostički radionuklid je 99m Tc. Odlične fizičke osobine, visok kvalitet i laka dostupnost po prihvatljivim cenama korišćenjem molibden-99/tehnecijum- 99m generatora i razvijena hemija doveli su do toga da ovaj radionuklid postane praktično nezamenjiv u ispitivanju skoro svih organa i tkiva u ljudskom organizmu. Dati su savremeni trendovi u razvoju proizvodnje radionuklida i radiofarmaceutika za primenu u terapijske svrhe. Prikazani su načini dobijanja radionuklida renijuma (186Re i 188Re) sa posebnim naglaskom na 188W/ 188Re generatoru. Dati su hemijski oblici i indikacije za primenu nekih radioaktivnih lekova obeleženih ovim radionuklidima. Prikazana su istraživanja sprovedena u Laboratoriji za radioizotope (Institut za nuklearne nauke «Vinča»).",
journal = "Facta Universitatis, Series: Physics, Chemistry and Technology",
title = "Radionuclidic generators for the production of technetium-99m and rhenium-188, Radionuklidni generatori za dobijanje tehnecijuma-99m i renijuma-188",
volume = "2",
number = "4",
pages = "235-243",
doi = "10.2298/FUPCT0204235V"
}

Vučina, J. L.,& Lukić, D. M.. (2002). Radionuclidic generators for the production of technetium-99m and rhenium-188. in Facta Universitatis, Series: Physics, Chemistry and Technology, 2(4), 235-243.
https://doi.org/10.2298/FUPCT0204235V

Vučina JL, Lukić DM. Radionuclidic generators for the production of technetium-99m and rhenium-188. in Facta Universitatis, Series: Physics, Chemistry and Technology. 2002;2(4):235-243.
doi:10.2298/FUPCT0204235V .

Vučina, Jurij L., Lukić, Dragoljub M., "Radionuclidic generators for the production of technetium-99m and rhenium-188" in Facta Universitatis, Series: Physics, Chemistry and Technology, 2, no. 4 (2002):235-243,
https://doi.org/10.2298/FUPCT0204235V . .