TY  - JOUR
AU  - Nićiforović, Ana
AU  - Adžić, Miroslav
AU  - Zarić, Božidarka
AU  - Radojčić, Marija
PY  - 2007
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6723
AB  - Naturally occurring phytoanthracycline, aloin, was used to radiosensitize HeLaS3 human cervix carcinoma cells. The results indicated that the cytotoxic adjuvant effect of aloin was synergistic with gammaionizing radiation at all drug concentrations and comparable to the cytotoxicity of 5-10 Gy ionizing radiation alone. Radiosensitization of HeLaS3 cells was achieved by 60 mu M aloin, which reduced the IC50 dose of ionizing radiation from 3.4 to 2 Gy. Ionizing radiation and aloin alone or in combination are shown to cause perturbation of the HeLaS3 cell-cycle and increase the percentage of cells in the DNA synthesis (S) phase of the cell cycle. While either of the agents applied alone causes programmed cell death by apoptosis, the simultaneous cell damage by both agents through the altered redox balance compromised cell capacity to conduct this program and led to synergic cytotoxic cell death by necrosis.
T2  - Russian Journal of Physical Chemistry A
T1  - Adjuvant antiproliferative and cytotoxic effect of aloin in irradiated HeLaS3 cells
VL  - 81
IS  - 9
SP  - 1463
EP  - 1466
DO  - 10.1134/S0036024407090221
ER  - 

@article{
author = "Nićiforović, Ana and Adžić, Miroslav and Zarić, Božidarka and Radojčić, Marija",
year = "2007",
abstract = "Naturally occurring phytoanthracycline, aloin, was used to radiosensitize HeLaS3 human cervix carcinoma cells. The results indicated that the cytotoxic adjuvant effect of aloin was synergistic with gammaionizing radiation at all drug concentrations and comparable to the cytotoxicity of 5-10 Gy ionizing radiation alone. Radiosensitization of HeLaS3 cells was achieved by 60 mu M aloin, which reduced the IC50 dose of ionizing radiation from 3.4 to 2 Gy. Ionizing radiation and aloin alone or in combination are shown to cause perturbation of the HeLaS3 cell-cycle and increase the percentage of cells in the DNA synthesis (S) phase of the cell cycle. While either of the agents applied alone causes programmed cell death by apoptosis, the simultaneous cell damage by both agents through the altered redox balance compromised cell capacity to conduct this program and led to synergic cytotoxic cell death by necrosis.",
journal = "Russian Journal of Physical Chemistry A",
title = "Adjuvant antiproliferative and cytotoxic effect of aloin in irradiated HeLaS3 cells",
volume = "81",
number = "9",
pages = "1463-1466",
doi = "10.1134/S0036024407090221"
}

Nićiforović, A., Adžić, M., Zarić, B.,& Radojčić, M.. (2007). Adjuvant antiproliferative and cytotoxic effect of aloin in irradiated HeLaS3 cells. in Russian Journal of Physical Chemistry A, 81(9), 1463-1466.
https://doi.org/10.1134/S0036024407090221

Nićiforović A, Adžić M, Zarić B, Radojčić M. Adjuvant antiproliferative and cytotoxic effect of aloin in irradiated HeLaS3 cells. in Russian Journal of Physical Chemistry A. 2007;81(9):1463-1466.
doi:10.1134/S0036024407090221 .

Nićiforović, Ana, Adžić, Miroslav, Zarić, Božidarka, Radojčić, Marija, "Adjuvant antiproliferative and cytotoxic effect of aloin in irradiated HeLaS3 cells" in Russian Journal of Physical Chemistry A, 81, no. 9 (2007):1463-1466,
https://doi.org/10.1134/S0036024407090221 . .