TY  - JOUR
AU  - Gavrilović, Ljubica
AU  - Popović, Nataša M.
AU  - Stojiljković, Vesna
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Pavlović, Ivan
AU  - Pajović, Snežana B.
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9617
AB  - This study aimed to investigate the effects of chronic restraint stress (CRS) on the protein levels of dopamine-β-hydroxylase (DBH), noradrenaline transporter (NET), vesicular monoamine transporter 2 (VMAT2) and brain-derived neurotrophic factor (BDNF), as well as the concentration of noradrenaline (NA) in the rat hippocampus. The investigated parameters were quantified by Western blot analyses and ELISA kits. We found that CRS increased the protein levels of DBH by 30 %, VMAT2 by 11 %, BDNF by 11 % and the concentration of NA by 104 %, but decreased the protein levels of NET by 16 % in the hippocampus of chronically stressed rats. The molecular mechanisms by which CRS increased the hippocampal NA level are an important adaptive phenomenon of the noradrenergic system in the stress condition. © 2020 Charles University. All rights reserved.
T2  - Folia Biologica (Czech Republic)
T1  - Changes of Hippocampal Noradrenergic Capacity in Stress Condition
VL  - 66
IS  - 2
SP  - 81
EP  - 84
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9617
ER  - 

@article{
author = "Gavrilović, Ljubica and Popović, Nataša M. and Stojiljković, Vesna and Pejić, Snežana and Todorović, Ana and Pavlović, Ivan and Pajović, Snežana B.",
year = "2020",
abstract = "This study aimed to investigate the effects of chronic restraint stress (CRS) on the protein levels of dopamine-β-hydroxylase (DBH), noradrenaline transporter (NET), vesicular monoamine transporter 2 (VMAT2) and brain-derived neurotrophic factor (BDNF), as well as the concentration of noradrenaline (NA) in the rat hippocampus. The investigated parameters were quantified by Western blot analyses and ELISA kits. We found that CRS increased the protein levels of DBH by 30 %, VMAT2 by 11 %, BDNF by 11 % and the concentration of NA by 104 %, but decreased the protein levels of NET by 16 % in the hippocampus of chronically stressed rats. The molecular mechanisms by which CRS increased the hippocampal NA level are an important adaptive phenomenon of the noradrenergic system in the stress condition. © 2020 Charles University. All rights reserved.",
journal = "Folia Biologica (Czech Republic)",
title = "Changes of Hippocampal Noradrenergic Capacity in Stress Condition",
volume = "66",
number = "2",
pages = "81-84",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9617"
}

Gavrilović, L., Popović, N. M., Stojiljković, V., Pejić, S., Todorović, A., Pavlović, I.,& Pajović, S. B.. (2020). Changes of Hippocampal Noradrenergic Capacity in Stress Condition. in Folia Biologica (Czech Republic), 66(2), 81-84.
https://hdl.handle.net/21.15107/rcub_vinar_9617

Gavrilović L, Popović NM, Stojiljković V, Pejić S, Todorović A, Pavlović I, Pajović SB. Changes of Hippocampal Noradrenergic Capacity in Stress Condition. in Folia Biologica (Czech Republic). 2020;66(2):81-84.
https://hdl.handle.net/21.15107/rcub_vinar_9617 .

Gavrilović, Ljubica, Popović, Nataša M., Stojiljković, Vesna, Pejić, Snežana, Todorović, Ana, Pavlović, Ivan, Pajović, Snežana B., "Changes of Hippocampal Noradrenergic Capacity in Stress Condition" in Folia Biologica (Czech Republic), 66, no. 2 (2020):81-84,
https://hdl.handle.net/21.15107/rcub_vinar_9617 .

TY  - JOUR
AU  - Popović, Nataša M.
AU  - Stojiljković, Vesna
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Pavlović, Ivan
AU  - Gavrilović, Ljubica
AU  - Pajović, Snežana B.
PY  - 2019
UR  - https://www.hindawi.com/journals/omcl/2019/8745376/
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8085
AB  - This study examined the effects of lithium on gene expression and activity of the antioxidant enzymes copper zinc superoxide dismutase (SOD1), manganese superoxide dismutase (SOD2), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) in the hippocampus of chronically stressed rats. In addition, we examined the effects of lithium on anxiety behaviors, hippocampal concentrations of dopamine (DA) and malondialdehyde (MDA), protein levels of brain-derived neurotrophic factor (BDNF), tyrosine hydroxylase (TH), dopamine transporter (DAT), and catechol-O-methyltransferase (COMT), as well as activity of monoamine oxidase (MAO) in chronically stressed rats. The investigated parameters were quantified by real-time RT-PCR, Western blot analyses, and assays of enzyme activities. We found that lithium did not change gene expression of SOD1, CAT, GPx, and GR but decreased gene expression of SOD2 in chronically stressed rats. A very important result in this study was that lithium treatment decreased the enzyme activities of SOD1 and SOD2 but increased the enzyme activities of GPx and GR in stress condition, which indicates the control of redox balance. The reduced concentration of MDA confirms this. In addition, we found that lithium treatment decreased high protein levels of BDNF and DAT in chronically stressed rats to the level found in unstressed animals. Also, lithium treatment increased the expression of TH but decreased the enzyme activity of MAO B, which contributed to the increase of hippocampal concentration of DA in chronically stressed rats to the level of unstressed animals. Finally, lithium treatment in animals exposed to chronic stress increased the time spent in open arms. Lithium-induced modulation of hippocampal antioxidant status and attenuation of oxidative stress stabilized behavior in animals with high anxiety index. In addition, reduced oxidative stress was followed by the changes of both turnover of DA and levels of BDNF protein in chronically stressed rats treated with lithium. These findings may be important in preclinical research of the effects of lithium on oxidative stress level in pathological conditions.
T2  - Oxidative Medicine and Cellular Longevity
T1  - Modulation of Hippocampal Antioxidant Defense System in Chronically Stressed Rats by Lithium
VL  - 2019
SP  - 1
EP  - 11
DO  - 10.1155/2019/8745376
ER  - 

@article{
author = "Popović, Nataša M. and Stojiljković, Vesna and Pejić, Snežana and Todorović, Ana and Pavlović, Ivan and Gavrilović, Ljubica and Pajović, Snežana B.",
year = "2019",
abstract = "This study examined the effects of lithium on gene expression and activity of the antioxidant enzymes copper zinc superoxide dismutase (SOD1), manganese superoxide dismutase (SOD2), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) in the hippocampus of chronically stressed rats. In addition, we examined the effects of lithium on anxiety behaviors, hippocampal concentrations of dopamine (DA) and malondialdehyde (MDA), protein levels of brain-derived neurotrophic factor (BDNF), tyrosine hydroxylase (TH), dopamine transporter (DAT), and catechol-O-methyltransferase (COMT), as well as activity of monoamine oxidase (MAO) in chronically stressed rats. The investigated parameters were quantified by real-time RT-PCR, Western blot analyses, and assays of enzyme activities. We found that lithium did not change gene expression of SOD1, CAT, GPx, and GR but decreased gene expression of SOD2 in chronically stressed rats. A very important result in this study was that lithium treatment decreased the enzyme activities of SOD1 and SOD2 but increased the enzyme activities of GPx and GR in stress condition, which indicates the control of redox balance. The reduced concentration of MDA confirms this. In addition, we found that lithium treatment decreased high protein levels of BDNF and DAT in chronically stressed rats to the level found in unstressed animals. Also, lithium treatment increased the expression of TH but decreased the enzyme activity of MAO B, which contributed to the increase of hippocampal concentration of DA in chronically stressed rats to the level of unstressed animals. Finally, lithium treatment in animals exposed to chronic stress increased the time spent in open arms. Lithium-induced modulation of hippocampal antioxidant status and attenuation of oxidative stress stabilized behavior in animals with high anxiety index. In addition, reduced oxidative stress was followed by the changes of both turnover of DA and levels of BDNF protein in chronically stressed rats treated with lithium. These findings may be important in preclinical research of the effects of lithium on oxidative stress level in pathological conditions.",
journal = "Oxidative Medicine and Cellular Longevity",
title = "Modulation of Hippocampal Antioxidant Defense System in Chronically Stressed Rats by Lithium",
volume = "2019",
pages = "1-11",
doi = "10.1155/2019/8745376"
}

Popović, N. M., Stojiljković, V., Pejić, S., Todorović, A., Pavlović, I., Gavrilović, L.,& Pajović, S. B.. (2019). Modulation of Hippocampal Antioxidant Defense System in Chronically Stressed Rats by Lithium. in Oxidative Medicine and Cellular Longevity, 2019, 1-11.
https://doi.org/10.1155/2019/8745376

Popović NM, Stojiljković V, Pejić S, Todorović A, Pavlović I, Gavrilović L, Pajović SB. Modulation of Hippocampal Antioxidant Defense System in Chronically Stressed Rats by Lithium. in Oxidative Medicine and Cellular Longevity. 2019;2019:1-11.
doi:10.1155/2019/8745376 .

Popović, Nataša M., Stojiljković, Vesna, Pejić, Snežana, Todorović, Ana, Pavlović, Ivan, Gavrilović, Ljubica, Pajović, Snežana B., "Modulation of Hippocampal Antioxidant Defense System in Chronically Stressed Rats by Lithium" in Oxidative Medicine and Cellular Longevity, 2019 (2019):1-11,
https://doi.org/10.1155/2019/8745376 . .

TY  - JOUR
AU  - Todorović, Ana
AU  - Pejić, Snežana
AU  - Gavrilović, Ljubica
AU  - Pavlović, Ivan
AU  - Stojiljković, Vesna
AU  - Popović, Nataša M.
AU  - Pajović, Snežana B.
PY  - 2019
UR  - https://www.mdpi.com/2076-3921/8/4/97
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8403
AB  - We previously found that compared to patients with benign uterine diseases (polyps, myomas), patients with premalignant (hyperplasia simplex and complex) and malignant (adenocarcinoma) lesions had enhanced lipid peroxidation and altered uterine antioxidant enzyme (AOE) activities. To further elucidate the mechanism of the observed changes, we examined protein and mRNA levels of copper-zinc superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and transcription factor Nrf2. We also examined correlations of AOE expression with AOE activity, lipid hydroperoxides (LOOH) level, and level of Nrf2. Our results showed decreased CuZnSOD, CAT, and Nrf2 levels, and increased GPx and GR levels in hyperplasias, while in patients with adenocarcinoma, the level of CAT was decreased and GR was increased, compared to benign groups. Similar changes in mRNA levels were also detected, indicating predominantly translational control of the AOE expression. The positive correlation of enzyme expression/activity was recorded for CuZnSOD, GPx, and GR, but only among groups with benign diseases. Only GR and GPx expressions were positively correlated with LOOH. Nrf2 protein was positively correlated with mRNA levels of CuZnSOD and GR. Observed results indicate involvement of diverse redox mechanisms in etiopathogenesis of different gynecological diseases, and may improve redox-based approaches in current clinical practice.
T2  - Antioxidants
T1  - Expression of Antioxidant Enzymes in Patients with Uterine Polyp, Myoma, Hyperplasia, and Adenocarcinoma
VL  - 8
IS  - 4
SP  - 97
DO  - 10.3390/antiox8040097
ER  - 

@article{
author = "Todorović, Ana and Pejić, Snežana and Gavrilović, Ljubica and Pavlović, Ivan and Stojiljković, Vesna and Popović, Nataša M. and Pajović, Snežana B.",
year = "2019",
abstract = "We previously found that compared to patients with benign uterine diseases (polyps, myomas), patients with premalignant (hyperplasia simplex and complex) and malignant (adenocarcinoma) lesions had enhanced lipid peroxidation and altered uterine antioxidant enzyme (AOE) activities. To further elucidate the mechanism of the observed changes, we examined protein and mRNA levels of copper-zinc superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and transcription factor Nrf2. We also examined correlations of AOE expression with AOE activity, lipid hydroperoxides (LOOH) level, and level of Nrf2. Our results showed decreased CuZnSOD, CAT, and Nrf2 levels, and increased GPx and GR levels in hyperplasias, while in patients with adenocarcinoma, the level of CAT was decreased and GR was increased, compared to benign groups. Similar changes in mRNA levels were also detected, indicating predominantly translational control of the AOE expression. The positive correlation of enzyme expression/activity was recorded for CuZnSOD, GPx, and GR, but only among groups with benign diseases. Only GR and GPx expressions were positively correlated with LOOH. Nrf2 protein was positively correlated with mRNA levels of CuZnSOD and GR. Observed results indicate involvement of diverse redox mechanisms in etiopathogenesis of different gynecological diseases, and may improve redox-based approaches in current clinical practice.",
journal = "Antioxidants",
title = "Expression of Antioxidant Enzymes in Patients with Uterine Polyp, Myoma, Hyperplasia, and Adenocarcinoma",
volume = "8",
number = "4",
pages = "97",
doi = "10.3390/antiox8040097"
}

Todorović, A., Pejić, S., Gavrilović, L., Pavlović, I., Stojiljković, V., Popović, N. M.,& Pajović, S. B.. (2019). Expression of Antioxidant Enzymes in Patients with Uterine Polyp, Myoma, Hyperplasia, and Adenocarcinoma. in Antioxidants, 8(4), 97.
https://doi.org/10.3390/antiox8040097

Todorović A, Pejić S, Gavrilović L, Pavlović I, Stojiljković V, Popović NM, Pajović SB. Expression of Antioxidant Enzymes in Patients with Uterine Polyp, Myoma, Hyperplasia, and Adenocarcinoma. in Antioxidants. 2019;8(4):97.
doi:10.3390/antiox8040097 .

Todorović, Ana, Pejić, Snežana, Gavrilović, Ljubica, Pavlović, Ivan, Stojiljković, Vesna, Popović, Nataša M., Pajović, Snežana B., "Expression of Antioxidant Enzymes in Patients with Uterine Polyp, Myoma, Hyperplasia, and Adenocarcinoma" in Antioxidants, 8, no. 4 (2019):97,
https://doi.org/10.3390/antiox8040097 . .

TY  - JOUR
AU  - Popović, Nataša M.
AU  - Pajović, Snežana B.
AU  - Stojiljković, Vesna
AU  - Todorović, Ana
AU  - Pejić, Snežana
AU  - Pavlović, Ivan
AU  - Gavrilović, Ljubica
PY  - 2018
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8404
AB  - The effects of chronic restraint stress (CRS, 2 h during 14 days) on gene expression of tyrosine hydroxylase (TH), catechol-O-methyltransferase (COMT), and glutathione peroxidase (GPx) were studied in the rat hippocampus. Changes in the dopamine (DA) concentration and activities of monoamine oxidases (MAO A and MAO B) and GPx in this cerebral structure of chronically stressed rats were also examined. The investigated parameters were quantified using real-time RT-PCR, Western blot analyses, and assay of enzymatic activity. We found that CRS decreased the TH protein level and DA concentration, which probably confirms the statement that de novo synthesis of DA is suppressed under stress conditions. The increased activities of MAO B, as well as the increased level of COMT protein, are believed to be related to intensified DA catabolism conditions. Also, a decreased activity of GPx in the hippocampus of chronically stressed animals was found. The increased enzymatic activity of MAO B negatively correlated with the reduced activity of GPx under the above-mentioned stress conditions. These events in the hippocampus of chronically stressed animals could synergistically cause oxidative damage to the mitochondria. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
T2  - Neurophysiology
T1  - Activities of the Dopaminergic System and Glutathione Antioxidant System in the Hippocampus of Stressed rats
VL  - 50
IS  - 5
SP  - 332
EP  - 338
DO  - 10.1007/s11062-019-09758-z
ER  - 

@article{
author = "Popović, Nataša M. and Pajović, Snežana B. and Stojiljković, Vesna and Todorović, Ana and Pejić, Snežana and Pavlović, Ivan and Gavrilović, Ljubica",
year = "2018",
abstract = "The effects of chronic restraint stress (CRS, 2 h during 14 days) on gene expression of tyrosine hydroxylase (TH), catechol-O-methyltransferase (COMT), and glutathione peroxidase (GPx) were studied in the rat hippocampus. Changes in the dopamine (DA) concentration and activities of monoamine oxidases (MAO A and MAO B) and GPx in this cerebral structure of chronically stressed rats were also examined. The investigated parameters were quantified using real-time RT-PCR, Western blot analyses, and assay of enzymatic activity. We found that CRS decreased the TH protein level and DA concentration, which probably confirms the statement that de novo synthesis of DA is suppressed under stress conditions. The increased activities of MAO B, as well as the increased level of COMT protein, are believed to be related to intensified DA catabolism conditions. Also, a decreased activity of GPx in the hippocampus of chronically stressed animals was found. The increased enzymatic activity of MAO B negatively correlated with the reduced activity of GPx under the above-mentioned stress conditions. These events in the hippocampus of chronically stressed animals could synergistically cause oxidative damage to the mitochondria. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.",
journal = "Neurophysiology",
title = "Activities of the Dopaminergic System and Glutathione Antioxidant System in the Hippocampus of Stressed rats",
volume = "50",
number = "5",
pages = "332-338",
doi = "10.1007/s11062-019-09758-z"
}

Popović, N. M., Pajović, S. B., Stojiljković, V., Todorović, A., Pejić, S., Pavlović, I.,& Gavrilović, L.. (2018). Activities of the Dopaminergic System and Glutathione Antioxidant System in the Hippocampus of Stressed rats. in Neurophysiology, 50(5), 332-338.
https://doi.org/10.1007/s11062-019-09758-z

Popović NM, Pajović SB, Stojiljković V, Todorović A, Pejić S, Pavlović I, Gavrilović L. Activities of the Dopaminergic System and Glutathione Antioxidant System in the Hippocampus of Stressed rats. in Neurophysiology. 2018;50(5):332-338.
doi:10.1007/s11062-019-09758-z .

Popović, Nataša M., Pajović, Snežana B., Stojiljković, Vesna, Todorović, Ana, Pejić, Snežana, Pavlović, Ivan, Gavrilović, Ljubica, "Activities of the Dopaminergic System and Glutathione Antioxidant System in the Hippocampus of Stressed rats" in Neurophysiology, 50, no. 5 (2018):332-338,
https://doi.org/10.1007/s11062-019-09758-z . .

TY  - CONF
AU  - Stojiljković, Vesna
AU  - Gavrilović, Ljubica
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Popović, Nataša M.
AU  - Pavlović, Ivan
AU  - Pajović, Snežana B.
PY  - 2017
UR  - http://www.rad-proceedings.org/paper.php?id=152
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7995
AB  - Celiac disease (CD) is an autoimmune disorder provoked by the wheat gluten and related proteins from other grains. The only treatment for the patients is a lifelong gluten free diet (GFD). Oxidative stress has been implicated in the pathogenesis of CD. The aim of this study was to examine the modulation of the biochemical response to oxidative stress in children affected by CD. The study involved peripheral blood samples and small intestinal biopsies from 69 children diagnosed with CD. According to the histological findings, patients were divided into following groups: Marsh 0: normal mucosa with no signs of inflammation (n=31); Marsh 1: mucosa was characterized by intraepithelial lymphocytosis (n=5); Marsh 2: intraepithelial lymphocytosis was accompanied by crypt hyperplasia (n=4); Marsh 3a: mucosa showed partial villous atrophy (n=20); Marsh 3b: subtotal villous atrophy was present (n=9). For the statistical purposes groups Marsh 1 and Marsh 2 were treated as one (Marsh 1+2, n=9). The activities and protein levels of copper, zinc superoxide dismutase (CuZnSOD) and manganese SOD (MnSOD), as well as the concentrations of lipid hydroperoxides (LOOH) were determined in intestinal biopsies, while in the peripheral blood, MnSOD activity was not measured, due to the methodological obstacles. CuZnSOD activity in the blood varied significantly between the analyzed groups. Marsh 3a and Marsh 3b had increased CuZnSOD activity comparing to the Marsh 0 (P < 0.05). LOOH concentration also varied significantly. LOOH level was higher in the blood of Marsh 3a (P < 0.001) and Marsh 3b (P < 0.05), than in Marsh 0. In the biopsy samples, MnSOD activity and LOOH concentration showed significant differences between the groups, while no significant difference was found for CuZnSOD activity. In comparison to Marsh 0, MnSOD activity was significantly elevated in Marsh 3a (P < 0.01). Significant increase in LOOH concentration was found in Marsh 3a (P < 0.001) and Marsh 3b (P < 0.01), comparing to Marsh 0. In addition, Marsh 3a group had higher LOOH concentration than Marsh 1+2. Relative MnSOD and CuZnSOD protein level in the peripheral blood and intestinal mucosa did not vary significantly between the analyzed groups. Positive correlations were found between the severity of mucosal lesion and CuZnSOD activity (P < 0.001), as well as LOOH concentration (P < 0.001) in the peripheral blood. Similar correlations were found also in intestinal mucosa: MnSOD: P < 0.05; CuZnSOD: P < 0.05; LOOH: P < 0.001. Our results show that oxidant/antioxidant balance is disturbed in CD patients with mucosal lesions. An increase in SOD activity as a consequence of oxidant pressure is not enough to maintain the normal level of free radicals, which leads to enhanced lipid peroxidation. These processes persist even in some patients on a long-term GFD.
PB  - RAD Association
C3  - RAD Conference Proceedings
T1  - Superoxide dismutase and lipid peroxidation in children affected by celiac disease
VL  - 2
SP  - 237
EP  - 242
DO  - 10.21175/RadProc.2017.49
ER  - 

@conference{
author = "Stojiljković, Vesna and Gavrilović, Ljubica and Pejić, Snežana and Todorović, Ana and Popović, Nataša M. and Pavlović, Ivan and Pajović, Snežana B.",
year = "2017",
abstract = "Celiac disease (CD) is an autoimmune disorder provoked by the wheat gluten and related proteins from other grains. The only treatment for the patients is a lifelong gluten free diet (GFD). Oxidative stress has been implicated in the pathogenesis of CD. The aim of this study was to examine the modulation of the biochemical response to oxidative stress in children affected by CD. The study involved peripheral blood samples and small intestinal biopsies from 69 children diagnosed with CD. According to the histological findings, patients were divided into following groups: Marsh 0: normal mucosa with no signs of inflammation (n=31); Marsh 1: mucosa was characterized by intraepithelial lymphocytosis (n=5); Marsh 2: intraepithelial lymphocytosis was accompanied by crypt hyperplasia (n=4); Marsh 3a: mucosa showed partial villous atrophy (n=20); Marsh 3b: subtotal villous atrophy was present (n=9). For the statistical purposes groups Marsh 1 and Marsh 2 were treated as one (Marsh 1+2, n=9). The activities and protein levels of copper, zinc superoxide dismutase (CuZnSOD) and manganese SOD (MnSOD), as well as the concentrations of lipid hydroperoxides (LOOH) were determined in intestinal biopsies, while in the peripheral blood, MnSOD activity was not measured, due to the methodological obstacles. CuZnSOD activity in the blood varied significantly between the analyzed groups. Marsh 3a and Marsh 3b had increased CuZnSOD activity comparing to the Marsh 0 (P < 0.05). LOOH concentration also varied significantly. LOOH level was higher in the blood of Marsh 3a (P < 0.001) and Marsh 3b (P < 0.05), than in Marsh 0. In the biopsy samples, MnSOD activity and LOOH concentration showed significant differences between the groups, while no significant difference was found for CuZnSOD activity. In comparison to Marsh 0, MnSOD activity was significantly elevated in Marsh 3a (P < 0.01). Significant increase in LOOH concentration was found in Marsh 3a (P < 0.001) and Marsh 3b (P < 0.01), comparing to Marsh 0. In addition, Marsh 3a group had higher LOOH concentration than Marsh 1+2. Relative MnSOD and CuZnSOD protein level in the peripheral blood and intestinal mucosa did not vary significantly between the analyzed groups. Positive correlations were found between the severity of mucosal lesion and CuZnSOD activity (P < 0.001), as well as LOOH concentration (P < 0.001) in the peripheral blood. Similar correlations were found also in intestinal mucosa: MnSOD: P < 0.05; CuZnSOD: P < 0.05; LOOH: P < 0.001. Our results show that oxidant/antioxidant balance is disturbed in CD patients with mucosal lesions. An increase in SOD activity as a consequence of oxidant pressure is not enough to maintain the normal level of free radicals, which leads to enhanced lipid peroxidation. These processes persist even in some patients on a long-term GFD.",
publisher = "RAD Association",
journal = "RAD Conference Proceedings",
title = "Superoxide dismutase and lipid peroxidation in children affected by celiac disease",
volume = "2",
pages = "237-242",
doi = "10.21175/RadProc.2017.49"
}

Stojiljković, V., Gavrilović, L., Pejić, S., Todorović, A., Popović, N. M., Pavlović, I.,& Pajović, S. B.. (2017). Superoxide dismutase and lipid peroxidation in children affected by celiac disease. in RAD Conference Proceedings
RAD Association., 2, 237-242.
https://doi.org/10.21175/RadProc.2017.49

Stojiljković V, Gavrilović L, Pejić S, Todorović A, Popović NM, Pavlović I, Pajović SB. Superoxide dismutase and lipid peroxidation in children affected by celiac disease. in RAD Conference Proceedings. 2017;2:237-242.
doi:10.21175/RadProc.2017.49 .

Stojiljković, Vesna, Gavrilović, Ljubica, Pejić, Snežana, Todorović, Ana, Popović, Nataša M., Pavlović, Ivan, Pajović, Snežana B., "Superoxide dismutase and lipid peroxidation in children affected by celiac disease" in RAD Conference Proceedings, 2 (2017):237-242,
https://doi.org/10.21175/RadProc.2017.49 . .

TY  - CONF
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Stojiljković, Vesna
AU  - Gavrilović, Ljubica
AU  - Popović, Nataša M.
AU  - Pavlović, Ivan
AU  - Pajović, Snežana B.
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7131
AB  - Endometrial hyperplasia complex is gynecological disorder characterized by morphological irregularities of glands shape and size. Antioxidant enzymes (AOE), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR), have an essential role in preventing oxidative damage in cell caused by reactive oxygen species (ROS). In this study, we examined the AO status in hyperplastic tissue of patients in menstrual cycle (follicular and luteal phase) and in postmenopause, as well as the relationship between sex hormones and AO parameters. The phase-related activity of GPx and GR in examined patients was significantly different than in healthy women. A significant negative correlation between FSH/LH level and GPx activiy was observed. Endometrial hyperplasias are considered as precancerous lesions and are treated either conservatively or surgicaly, and also by radiation therapy. Since the effects of these therapies are associated with AO and hormonal changes, our results may contribute to the prediction of potential therapeutic efficacy and to selection of the most effective treatment for hyperplasia complex.
C3  - RAD Conference Proceedings
T1  - Antioxidant Enzymes in Women with Hyperplasia Complex: Relation with Sex Hormones
SP  - 467
EP  - 470
UR  - https://hdl.handle.net/21.15107/rcub_vinar_7131
ER  - 

@conference{
author = "Pejić, Snežana and Todorović, Ana and Stojiljković, Vesna and Gavrilović, Ljubica and Popović, Nataša M. and Pavlović, Ivan and Pajović, Snežana B.",
year = "2015",
abstract = "Endometrial hyperplasia complex is gynecological disorder characterized by morphological irregularities of glands shape and size. Antioxidant enzymes (AOE), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR), have an essential role in preventing oxidative damage in cell caused by reactive oxygen species (ROS). In this study, we examined the AO status in hyperplastic tissue of patients in menstrual cycle (follicular and luteal phase) and in postmenopause, as well as the relationship between sex hormones and AO parameters. The phase-related activity of GPx and GR in examined patients was significantly different than in healthy women. A significant negative correlation between FSH/LH level and GPx activiy was observed. Endometrial hyperplasias are considered as precancerous lesions and are treated either conservatively or surgicaly, and also by radiation therapy. Since the effects of these therapies are associated with AO and hormonal changes, our results may contribute to the prediction of potential therapeutic efficacy and to selection of the most effective treatment for hyperplasia complex.",
journal = "RAD Conference Proceedings",
title = "Antioxidant Enzymes in Women with Hyperplasia Complex: Relation with Sex Hormones",
pages = "467-470",
url = "https://hdl.handle.net/21.15107/rcub_vinar_7131"
}

Pejić, S., Todorović, A., Stojiljković, V., Gavrilović, L., Popović, N. M., Pavlović, I.,& Pajović, S. B.. (2015). Antioxidant Enzymes in Women with Hyperplasia Complex: Relation with Sex Hormones. in RAD Conference Proceedings, 467-470.
https://hdl.handle.net/21.15107/rcub_vinar_7131

Pejić S, Todorović A, Stojiljković V, Gavrilović L, Popović NM, Pavlović I, Pajović SB. Antioxidant Enzymes in Women with Hyperplasia Complex: Relation with Sex Hormones. in RAD Conference Proceedings. 2015;:467-470.
https://hdl.handle.net/21.15107/rcub_vinar_7131 .

Pejić, Snežana, Todorović, Ana, Stojiljković, Vesna, Gavrilović, Ljubica, Popović, Nataša M., Pavlović, Ivan, Pajović, Snežana B., "Antioxidant Enzymes in Women with Hyperplasia Complex: Relation with Sex Hormones" in RAD Conference Proceedings (2015):467-470,
https://hdl.handle.net/21.15107/rcub_vinar_7131 .

TY  - CHAP
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Stojiljković, Vesna
AU  - Pavlović, Ivan
AU  - Gavrilović, Ljubica
AU  - Popović, Nataša M.
AU  - Pajović, Snežana B.
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8408
AB  - Cancer of the reproductive tract is an important source of morbidity and mortality among women worldwide. Factors affecting endometrial cancer and endometrial hyperplasia are known to be similar. Endometrial hyperplasia is abnormal proliferation of the glands and the stroma resulting in architectural and cytological modifications. Due to hormonal changes, this condition is most common among women who are nearing the menopause or have reached the menopause. Antioxidant system has a role in preventing cancer initiation and promotion. Since the carcinogenesis occurs in several stages, it is likely that the antioxidant defense depends on the type of cell and tissue. The objective of this study was to investigate whether antioxidant enzymes activities and lipid hydroperoxides concentration in patients with endometrial hyperplasia are influenced by the changes in sex hormones level (estradiol, progesterone, FSH, and LH) during the menstrual cycle and in postmenopause. The material we used consisted of blood and endometrial tissue specimens of women diagnosed with endometrial hyperplasia simplex. Patients were divided in groups depending on the phase of the menstrual cycle: follicular phase, luteal phase and postmenopause. The activities of antioxidant enzymes and the lipid hydroperoxides level were compared among the phases to test the differences and a linear regression model was used to evaluate the associations between hormone levels and antioxidant/oxidant variables. In the blood of examined patients, we observed a phase-related changes of LOOH concentrations. Significant negative correlation between FSH concentration and GR activity (r= -0.42, p<0.05) and significant positive correlation between LH and LOOH concentrations (r= 0.038, p<0.05) was found. In hyperplasia simplex tissue we recorded significant phase-related changes of LOOH level as well as of AO enzyme activities. SOD and CAT had similar activity pattern, which was higher in luteal phase and in postmenopause, compared to follicular phase (p<0.05). GPx and GR activities did not show any statistical difference. Also, negative correlation between progesterone and GR activity (r=-0.036, p<0.05) was observed. Hormonal influence on AO system is of importance in gynecological diseases etiology since they may promote cell proliferation but are also used in conservative therapy, especially for hyperplasia simplex. However, the role of ROS production as a risk factor for endometrial hyperplasia still needs to be clarified as well as the role of AO status in response to gonadotropins and sex steroids.
T2  - Basic Principles and Clinical Significance of Oxidative Stress, (ed.) Sivakumar Joghi Thatha Gowder
T1  - Antioxidant Status and Sex Hormones in Women with Simple Endometrial Hyperplasia
IS  - Ch. 9
SP  - 243
EP  - 279
DO  - 10.5772/60853
ER  - 

@inbook{
editor = "Gowder, Sivakumar Joghi Thatha",
author = "Pejić, Snežana and Todorović, Ana and Stojiljković, Vesna and Pavlović, Ivan and Gavrilović, Ljubica and Popović, Nataša M. and Pajović, Snežana B.",
year = "2015",
abstract = "Cancer of the reproductive tract is an important source of morbidity and mortality among women worldwide. Factors affecting endometrial cancer and endometrial hyperplasia are known to be similar. Endometrial hyperplasia is abnormal proliferation of the glands and the stroma resulting in architectural and cytological modifications. Due to hormonal changes, this condition is most common among women who are nearing the menopause or have reached the menopause. Antioxidant system has a role in preventing cancer initiation and promotion. Since the carcinogenesis occurs in several stages, it is likely that the antioxidant defense depends on the type of cell and tissue. The objective of this study was to investigate whether antioxidant enzymes activities and lipid hydroperoxides concentration in patients with endometrial hyperplasia are influenced by the changes in sex hormones level (estradiol, progesterone, FSH, and LH) during the menstrual cycle and in postmenopause. The material we used consisted of blood and endometrial tissue specimens of women diagnosed with endometrial hyperplasia simplex. Patients were divided in groups depending on the phase of the menstrual cycle: follicular phase, luteal phase and postmenopause. The activities of antioxidant enzymes and the lipid hydroperoxides level were compared among the phases to test the differences and a linear regression model was used to evaluate the associations between hormone levels and antioxidant/oxidant variables. In the blood of examined patients, we observed a phase-related changes of LOOH concentrations. Significant negative correlation between FSH concentration and GR activity (r= -0.42, p<0.05) and significant positive correlation between LH and LOOH concentrations (r= 0.038, p<0.05) was found. In hyperplasia simplex tissue we recorded significant phase-related changes of LOOH level as well as of AO enzyme activities. SOD and CAT had similar activity pattern, which was higher in luteal phase and in postmenopause, compared to follicular phase (p<0.05). GPx and GR activities did not show any statistical difference. Also, negative correlation between progesterone and GR activity (r=-0.036, p<0.05) was observed. Hormonal influence on AO system is of importance in gynecological diseases etiology since they may promote cell proliferation but are also used in conservative therapy, especially for hyperplasia simplex. However, the role of ROS production as a risk factor for endometrial hyperplasia still needs to be clarified as well as the role of AO status in response to gonadotropins and sex steroids.",
journal = "Basic Principles and Clinical Significance of Oxidative Stress, (ed.) Sivakumar Joghi Thatha Gowder",
booktitle = "Antioxidant Status and Sex Hormones in Women with Simple Endometrial Hyperplasia",
number = "Ch. 9",
pages = "243-279",
doi = "10.5772/60853"
}

Gowder, S. J. T., Pejić, S., Todorović, A., Stojiljković, V., Pavlović, I., Gavrilović, L., Popović, N. M.,& Pajović, S. B.. (2015). Antioxidant Status and Sex Hormones in Women with Simple Endometrial Hyperplasia. in Basic Principles and Clinical Significance of Oxidative Stress, (ed.) Sivakumar Joghi Thatha Gowder(Ch. 9), 243-279.
https://doi.org/10.5772/60853

Gowder SJT, Pejić S, Todorović A, Stojiljković V, Pavlović I, Gavrilović L, Popović NM, Pajović SB. Antioxidant Status and Sex Hormones in Women with Simple Endometrial Hyperplasia. in Basic Principles and Clinical Significance of Oxidative Stress, (ed.) Sivakumar Joghi Thatha Gowder. 2015;(Ch. 9):243-279.
doi:10.5772/60853 .

Gowder, Sivakumar Joghi Thatha, Pejić, Snežana, Todorović, Ana, Stojiljković, Vesna, Pavlović, Ivan, Gavrilović, Ljubica, Popović, Nataša M., Pajović, Snežana B., "Antioxidant Status and Sex Hormones in Women with Simple Endometrial Hyperplasia" in Basic Principles and Clinical Significance of Oxidative Stress, (ed.) Sivakumar Joghi Thatha Gowder, no. Ch. 9 (2015):243-279,
https://doi.org/10.5772/60853 . .

TY  - JOUR
AU  - Pejić, Snežana
AU  - Kasapović, Jelena
AU  - Todorović, Ana
AU  - Stojiljković, Vesna
AU  - Gavrilović, Ljubica
AU  - Popović, Nataša M.
AU  - Pajović, Snežana B.
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5705
AB  - Objective: To investigate whether antioxidant enzyme activities (superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase) and lipid hydroperoxide levels in patients with endometrial polyps are influenced by the changes in sex hormones (estradiol, progesterone, FSH, and LH) during the menstrual cycle and in postmenopause. Study design: The material consisted of blood and endometrial tissue specimens from women diagnosed with endometrial polyps. Patients were divided into groups depending on the phase of the menstrual cycle - follicular or luteal - and the postmenopause. The activities of antioxidant enzymes and the lipid hydroperoxide levels were compared among the phases and a linear regression model was used to evaluate the associations between hormones and antioxidant/oxidant variables. Results: In the blood of examined women, a significant difference in superoxide dismutase activity and lipid hydroperoxide levels was recorded among the phases. There was also a positive correlation between the estradiol concentration and superoxide dismutase. In polyp tissue, we recorded a phase-related difference in superoxide dismutase and glutathione peroxidase activities as well as in the lipid hydroperoxide levels. A negative correlation was observed between FSH/LH and glutathione peroxidase, and between LH and superoxide dismutase. Conclusion: Antioxidant enzymes and lipid hydroperoxide levels in patients with endometrial polyps are influenced by the changes in sex hormones during the menstrual cycle and after the menopause, pointing to a role of the observed relationship in polyp etiology. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
T2  - European Journal of Obstetrics Gynecology and Reproductive Biology
T1  - Antioxidant enzymes in women with endometrial polyps: relation with sex hormones
VL  - 170
IS  - 1
SP  - 241
EP  - 246
DO  - 10.1016/j.ejogrb.2013.06.024
ER  - 

@article{
author = "Pejić, Snežana and Kasapović, Jelena and Todorović, Ana and Stojiljković, Vesna and Gavrilović, Ljubica and Popović, Nataša M. and Pajović, Snežana B.",
year = "2013",
abstract = "Objective: To investigate whether antioxidant enzyme activities (superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase) and lipid hydroperoxide levels in patients with endometrial polyps are influenced by the changes in sex hormones (estradiol, progesterone, FSH, and LH) during the menstrual cycle and in postmenopause. Study design: The material consisted of blood and endometrial tissue specimens from women diagnosed with endometrial polyps. Patients were divided into groups depending on the phase of the menstrual cycle - follicular or luteal - and the postmenopause. The activities of antioxidant enzymes and the lipid hydroperoxide levels were compared among the phases and a linear regression model was used to evaluate the associations between hormones and antioxidant/oxidant variables. Results: In the blood of examined women, a significant difference in superoxide dismutase activity and lipid hydroperoxide levels was recorded among the phases. There was also a positive correlation between the estradiol concentration and superoxide dismutase. In polyp tissue, we recorded a phase-related difference in superoxide dismutase and glutathione peroxidase activities as well as in the lipid hydroperoxide levels. A negative correlation was observed between FSH/LH and glutathione peroxidase, and between LH and superoxide dismutase. Conclusion: Antioxidant enzymes and lipid hydroperoxide levels in patients with endometrial polyps are influenced by the changes in sex hormones during the menstrual cycle and after the menopause, pointing to a role of the observed relationship in polyp etiology. (C) 2013 Elsevier Ireland Ltd. All rights reserved.",
journal = "European Journal of Obstetrics Gynecology and Reproductive Biology",
title = "Antioxidant enzymes in women with endometrial polyps: relation with sex hormones",
volume = "170",
number = "1",
pages = "241-246",
doi = "10.1016/j.ejogrb.2013.06.024"
}

Pejić, S., Kasapović, J., Todorović, A., Stojiljković, V., Gavrilović, L., Popović, N. M.,& Pajović, S. B.. (2013). Antioxidant enzymes in women with endometrial polyps: relation with sex hormones. in European Journal of Obstetrics Gynecology and Reproductive Biology, 170(1), 241-246.
https://doi.org/10.1016/j.ejogrb.2013.06.024

Pejić S, Kasapović J, Todorović A, Stojiljković V, Gavrilović L, Popović NM, Pajović SB. Antioxidant enzymes in women with endometrial polyps: relation with sex hormones. in European Journal of Obstetrics Gynecology and Reproductive Biology. 2013;170(1):241-246.
doi:10.1016/j.ejogrb.2013.06.024 .

Pejić, Snežana, Kasapović, Jelena, Todorović, Ana, Stojiljković, Vesna, Gavrilović, Ljubica, Popović, Nataša M., Pajović, Snežana B., "Antioxidant enzymes in women with endometrial polyps: relation with sex hormones" in European Journal of Obstetrics Gynecology and Reproductive Biology, 170, no. 1 (2013):241-246,
https://doi.org/10.1016/j.ejogrb.2013.06.024 . .

TY  - JOUR
AU  - Kasapović, Jelena
AU  - Stojiljković, Vesna
AU  - Gavrilović, Ljubica
AU  - Popović, Nataša M.
AU  - Milićević, Zorka T.
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4959
AB  - Reactive oxygen species (ROS) are independently recognized to play a significant role in radiation-induced damage on healthy tissue and in aging process. However, an age-related alteration of antioxidant (AO) system in radiation response in humans is poorly investigated. The aim of this paper was to evaluate the irradiation effects on the activities and expression of AO system in the blood of healthy women during aging. Blood samples were irradiated with curative and palliative doses of 2Gy or 9Gy gamma-rays. AO capacity for detoxification of O-2 center dot(-) and H2O2 in response to 2Gy gamma-irradiation decreases in women above 58 years, while in response to 9Gy shows signs of weakening after 45 years of age. Due to reduction of AO capacity during aging, cytotoxic effects of curative and palliative doses of irradiation, mediated by ROS, may significantly increase in older subjects, while removal of H2O2 excess could reduce them.
T2  - Scientific World Journal
T1  - Antioxidant Protection against Curative and Palliative Doses of Ionizing Irradiation in Human Blood Decreases with Aging
DO  - 10.1100/2012/982594
ER  - 

@article{
author = "Kasapović, Jelena and Stojiljković, Vesna and Gavrilović, Ljubica and Popović, Nataša M. and Milićević, Zorka T.",
year = "2012",
abstract = "Reactive oxygen species (ROS) are independently recognized to play a significant role in radiation-induced damage on healthy tissue and in aging process. However, an age-related alteration of antioxidant (AO) system in radiation response in humans is poorly investigated. The aim of this paper was to evaluate the irradiation effects on the activities and expression of AO system in the blood of healthy women during aging. Blood samples were irradiated with curative and palliative doses of 2Gy or 9Gy gamma-rays. AO capacity for detoxification of O-2 center dot(-) and H2O2 in response to 2Gy gamma-irradiation decreases in women above 58 years, while in response to 9Gy shows signs of weakening after 45 years of age. Due to reduction of AO capacity during aging, cytotoxic effects of curative and palliative doses of irradiation, mediated by ROS, may significantly increase in older subjects, while removal of H2O2 excess could reduce them.",
journal = "Scientific World Journal",
title = "Antioxidant Protection against Curative and Palliative Doses of Ionizing Irradiation in Human Blood Decreases with Aging",
doi = "10.1100/2012/982594"
}

Kasapović, J., Stojiljković, V., Gavrilović, L., Popović, N. M.,& Milićević, Z. T.. (2012). Antioxidant Protection against Curative and Palliative Doses of Ionizing Irradiation in Human Blood Decreases with Aging. in Scientific World Journal.
https://doi.org/10.1100/2012/982594

Kasapović J, Stojiljković V, Gavrilović L, Popović NM, Milićević ZT. Antioxidant Protection against Curative and Palliative Doses of Ionizing Irradiation in Human Blood Decreases with Aging. in Scientific World Journal. 2012;.
doi:10.1100/2012/982594 .

Kasapović, Jelena, Stojiljković, Vesna, Gavrilović, Ljubica, Popović, Nataša M., Milićević, Zorka T., "Antioxidant Protection against Curative and Palliative Doses of Ionizing Irradiation in Human Blood Decreases with Aging" in Scientific World Journal (2012),
https://doi.org/10.1100/2012/982594 . .

TY  - JOUR
AU  - Stojiljković, Vesna
AU  - Pejić, Snežana
AU  - Kasapović, Jelena
AU  - Gavrilović, Ljubica
AU  - Stojiljković, Stanimir
AU  - Nikolić, Dragan
AU  - Pajović, Snežana B.
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4758
AB  - The celiac disease is an autoimmune gastrointestinal disorder caused by gluten from wheat, rye or barley. In genetically predisposed persons, gluten induces the immune-mediated inflammation of small intestinal mucosa. Histological lesions include intraepithelial lymphocytosis, crypt hypertrophy and villous atrophy, resulting in malabsorption of micro- and macronutrients. The only treatment for celiac patients is a permanent gluten-free diet (GFD). Reactive oxygen species (ROS) and oxidative stress are strongly associated with the celiac disease. Glutathione (GSH) is a main detoxifier of endogenous and exogenous ROS in the intestine. In order to explain the role of glutathione redox cycle in celiac patients, we examined the activities of GSH-related antioxidant (AO) enzymes glutathione peroxidase (GPx) and glutathione reductase (GR), as well as the concentration of GSH in small intestinal biopsies and peripheral blood of children affected by the celiac disease. The concentration of lipid hydroperoxides (LOOH) as markers of oxidative damage was measured in the same samples. The results clearly demonstrate a significant malfunction of GSH redox cycle with a concomitant decrease in the capacity to regenerate GSH and detoxify LOOH in celiac patients, even after several years of GFD. The oral administration of GSH and a diet rich in natural antioxidants, as well as appropriate dietary supplements, could be of great benefit to the patients.
T2  - Anais de Academia Brasileira de Ciencias
T1  - Glutathione redox cycle in small intestinal mucosa and peripheral blood of pediatric celiac disease patients
VL  - 84
IS  - 1
SP  - 175
EP  - 184
DO  - 10.1590/S0001-37652012000100018
ER  - 

@article{
author = "Stojiljković, Vesna and Pejić, Snežana and Kasapović, Jelena and Gavrilović, Ljubica and Stojiljković, Stanimir and Nikolić, Dragan and Pajović, Snežana B.",
year = "2012",
abstract = "The celiac disease is an autoimmune gastrointestinal disorder caused by gluten from wheat, rye or barley. In genetically predisposed persons, gluten induces the immune-mediated inflammation of small intestinal mucosa. Histological lesions include intraepithelial lymphocytosis, crypt hypertrophy and villous atrophy, resulting in malabsorption of micro- and macronutrients. The only treatment for celiac patients is a permanent gluten-free diet (GFD). Reactive oxygen species (ROS) and oxidative stress are strongly associated with the celiac disease. Glutathione (GSH) is a main detoxifier of endogenous and exogenous ROS in the intestine. In order to explain the role of glutathione redox cycle in celiac patients, we examined the activities of GSH-related antioxidant (AO) enzymes glutathione peroxidase (GPx) and glutathione reductase (GR), as well as the concentration of GSH in small intestinal biopsies and peripheral blood of children affected by the celiac disease. The concentration of lipid hydroperoxides (LOOH) as markers of oxidative damage was measured in the same samples. The results clearly demonstrate a significant malfunction of GSH redox cycle with a concomitant decrease in the capacity to regenerate GSH and detoxify LOOH in celiac patients, even after several years of GFD. The oral administration of GSH and a diet rich in natural antioxidants, as well as appropriate dietary supplements, could be of great benefit to the patients.",
journal = "Anais de Academia Brasileira de Ciencias",
title = "Glutathione redox cycle in small intestinal mucosa and peripheral blood of pediatric celiac disease patients",
volume = "84",
number = "1",
pages = "175-184",
doi = "10.1590/S0001-37652012000100018"
}

Stojiljković, V., Pejić, S., Kasapović, J., Gavrilović, L., Stojiljković, S., Nikolić, D.,& Pajović, S. B.. (2012). Glutathione redox cycle in small intestinal mucosa and peripheral blood of pediatric celiac disease patients. in Anais de Academia Brasileira de Ciencias, 84(1), 175-184.
https://doi.org/10.1590/S0001-37652012000100018

Stojiljković V, Pejić S, Kasapović J, Gavrilović L, Stojiljković S, Nikolić D, Pajović SB. Glutathione redox cycle in small intestinal mucosa and peripheral blood of pediatric celiac disease patients. in Anais de Academia Brasileira de Ciencias. 2012;84(1):175-184.
doi:10.1590/S0001-37652012000100018 .

Stojiljković, Vesna, Pejić, Snežana, Kasapović, Jelena, Gavrilović, Ljubica, Stojiljković, Stanimir, Nikolić, Dragan, Pajović, Snežana B., "Glutathione redox cycle in small intestinal mucosa and peripheral blood of pediatric celiac disease patients" in Anais de Academia Brasileira de Ciencias, 84, no. 1 (2012):175-184,
https://doi.org/10.1590/S0001-37652012000100018 . .

TY  - JOUR
AU  - Perendija, Branka R.
AU  - Despotović, Svetlana G.
AU  - Radovanovic, Tijana B.
AU  - Gavric, Jelena P.
AU  - Mitić, Slavica S. Borkovic
AU  - Pavlović, Slađan
AU  - Ognjanovic, Branka I.
AU  - Simic, Snezana B.
AU  - Pajović, Snežana B.
AU  - Saičić, Zorica S.
PY  - 2011
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4652
AB  - We investigated the biochemical and ultrastructural changes in the liver of the freshwater fish, European perch (Perca fluviatilis), in response to Aphanizomenon flos-aquae bloom in the Gruza Reservoir, Serbia. The activities of total manganese- and copper zinc-containing superoxide dismutase (Tot SOD, Mn-SOD, Cu/Zn-SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR) and biotransformation phase II enzyme glutathione-S-transferase (GST), as well as concentrations of total glutathione (GSH) and sulfhydryl (-SH) groups were examined before and during the bloom period. Mn-SOD activity was significantly higher, while the activities of Cu/Zn-SOD, CAT and GSH-Px and the concentration of the -SH groups were significantly lower during the bloom. The ultrastructure of the liver revealed necrotic and apoptotic damage to the hepatocytes during the bloom period. Our work represents the first study to report the influences of an Aphanizomenon flos-aquae bloom in the Gruza Reservoir on antioxidant biomarkers and on histopathological alterations in the liver of the freshwater fish European perch (Perca fluviatilis).
T2  - Archives of Biological Sciences
T1  - Biochemical and Ultrastructural Changes in the Liver of European Perch (Perca Fluviatilis L.) in Response to Cyanobacterial Bloom in the Gruza Reservoir
VL  - 63
IS  - 4
SP  - 979
EP  - 989
DO  - 10.2298/ABS1104979P
ER  - 

@article{
author = "Perendija, Branka R. and Despotović, Svetlana G. and Radovanovic, Tijana B. and Gavric, Jelena P. and Mitić, Slavica S. Borkovic and Pavlović, Slađan and Ognjanovic, Branka I. and Simic, Snezana B. and Pajović, Snežana B. and Saičić, Zorica S.",
year = "2011",
abstract = "We investigated the biochemical and ultrastructural changes in the liver of the freshwater fish, European perch (Perca fluviatilis), in response to Aphanizomenon flos-aquae bloom in the Gruza Reservoir, Serbia. The activities of total manganese- and copper zinc-containing superoxide dismutase (Tot SOD, Mn-SOD, Cu/Zn-SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR) and biotransformation phase II enzyme glutathione-S-transferase (GST), as well as concentrations of total glutathione (GSH) and sulfhydryl (-SH) groups were examined before and during the bloom period. Mn-SOD activity was significantly higher, while the activities of Cu/Zn-SOD, CAT and GSH-Px and the concentration of the -SH groups were significantly lower during the bloom. The ultrastructure of the liver revealed necrotic and apoptotic damage to the hepatocytes during the bloom period. Our work represents the first study to report the influences of an Aphanizomenon flos-aquae bloom in the Gruza Reservoir on antioxidant biomarkers and on histopathological alterations in the liver of the freshwater fish European perch (Perca fluviatilis).",
journal = "Archives of Biological Sciences",
title = "Biochemical and Ultrastructural Changes in the Liver of European Perch (Perca Fluviatilis L.) in Response to Cyanobacterial Bloom in the Gruza Reservoir",
volume = "63",
number = "4",
pages = "979-989",
doi = "10.2298/ABS1104979P"
}

Perendija, B. R., Despotović, S. G., Radovanovic, T. B., Gavric, J. P., Mitić, S. S. B., Pavlović, S., Ognjanovic, B. I., Simic, S. B., Pajović, S. B.,& Saičić, Z. S.. (2011). Biochemical and Ultrastructural Changes in the Liver of European Perch (Perca Fluviatilis L.) in Response to Cyanobacterial Bloom in the Gruza Reservoir. in Archives of Biological Sciences, 63(4), 979-989.
https://doi.org/10.2298/ABS1104979P

Perendija BR, Despotović SG, Radovanovic TB, Gavric JP, Mitić SSB, Pavlović S, Ognjanovic BI, Simic SB, Pajović SB, Saičić ZS. Biochemical and Ultrastructural Changes in the Liver of European Perch (Perca Fluviatilis L.) in Response to Cyanobacterial Bloom in the Gruza Reservoir. in Archives of Biological Sciences. 2011;63(4):979-989.
doi:10.2298/ABS1104979P .

Perendija, Branka R., Despotović, Svetlana G., Radovanovic, Tijana B., Gavric, Jelena P., Mitić, Slavica S. Borkovic, Pavlović, Slađan, Ognjanovic, Branka I., Simic, Snezana B., Pajović, Snežana B., Saičić, Zorica S., "Biochemical and Ultrastructural Changes in the Liver of European Perch (Perca Fluviatilis L.) in Response to Cyanobacterial Bloom in the Gruza Reservoir" in Archives of Biological Sciences, 63, no. 4 (2011):979-989,
https://doi.org/10.2298/ABS1104979P . .