Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200017 (University of Belgrade, Institute of Nuclear Sciences 'Vinča', Belgrade-Vinča)

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Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200017 (University of Belgrade, Institute of Nuclear Sciences 'Vinča', Belgrade-Vinča) (en)
Ministarstvo prosvete, nauke i tehnološkog razvoja Republike Srbije, Ugovor br. 451-03-68/2020-14/200017 (Univerzitet u Beogradu, Institut za nuklearne nauke Vinča, Beograd-Vinča) (sr_RS)
Министарство просвете, науке и технолошког развоја Републике Србије, Уговор бр. 451-03-68/2020-14/200017 (Универзитет у Београду, Институт за нуклеарне науке Винча, Београд-Винча) (sr)
Authors

Publications

Non-coding RNA and cholesteatoma

Jovanović, Ivan; Živković, Maja; Ješić, Snežana; Stanković, Aleksandra

TY  - JOUR
AU  - Jovanović, Ivan
AU  - Živković, Maja
AU  - Ješić, Snežana
AU  - Stanković, Aleksandra
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10115
AB  - Objective Cholesteatoma is a challenging chronic pathology of the middle ear for which pharmacologic therapies have not been developed yet. Cholesteatoma occurrence depends on the interplay between genetic and environmental factors while master regulators orchestrating disease progression are still unknown. Therefore, in this review, we will discuss the diagnostic and therapeutic potential of non-coding RNAs (ncRNA) as a new class of regulatory molecules. Methods We have comprehensively reviewed all articles investigating ncRNAs, specifically micro RNAs (miRNAs) and long ncRNAs (lncRNA/circRNA) in cholesteatoma tissue. Results Candidate miRNA approaches indicated that miR-21 and let-7a are the major miRNAs involved in cholesteatoma growth, migration, proliferation, bone destruction, and apoptosis. Regulatory potential for the same biological processes was also observed for miR-203a. The NF-kB/miR-802/PTEN regulatory network was in relation to observed miR-21 activity in cholesteatoma as well. High throughput approaches revealed additional ncRNAs implicated in cholesteatoma pathology. Competitive endogenous RNA (ceRNA) analysis highlighted lncRNA/circRNA that could be “endogenous sponge” for miR-21 and let-7a based on the hypothesis that RNA transcripts can communicate with and regulate each other by using shared miRNA response elements. Conclusion In this review, we summarize the discoveries and role of ncRNA in major pathways in cholesteatoma and highlight the potential of miRNA-based therapeutics in the treatment of cholesteatoma. Level of Evidence: NA.
T2  - Laryngoscope Investigative Otolaryngology
T2  - Laryngoscope Investigative Otolaryngology
T1  - Non-coding RNA and cholesteatoma
DO  - 10.1002/lio2.728
ER  - 
@article{
author = "Jovanović, Ivan and Živković, Maja and Ješić, Snežana and Stanković, Aleksandra",
abstract = "Objective Cholesteatoma is a challenging chronic pathology of the middle ear for which pharmacologic therapies have not been developed yet. Cholesteatoma occurrence depends on the interplay between genetic and environmental factors while master regulators orchestrating disease progression are still unknown. Therefore, in this review, we will discuss the diagnostic and therapeutic potential of non-coding RNAs (ncRNA) as a new class of regulatory molecules. Methods We have comprehensively reviewed all articles investigating ncRNAs, specifically micro RNAs (miRNAs) and long ncRNAs (lncRNA/circRNA) in cholesteatoma tissue. Results Candidate miRNA approaches indicated that miR-21 and let-7a are the major miRNAs involved in cholesteatoma growth, migration, proliferation, bone destruction, and apoptosis. Regulatory potential for the same biological processes was also observed for miR-203a. The NF-kB/miR-802/PTEN regulatory network was in relation to observed miR-21 activity in cholesteatoma as well. High throughput approaches revealed additional ncRNAs implicated in cholesteatoma pathology. Competitive endogenous RNA (ceRNA) analysis highlighted lncRNA/circRNA that could be “endogenous sponge” for miR-21 and let-7a based on the hypothesis that RNA transcripts can communicate with and regulate each other by using shared miRNA response elements. Conclusion In this review, we summarize the discoveries and role of ncRNA in major pathways in cholesteatoma and highlight the potential of miRNA-based therapeutics in the treatment of cholesteatoma. Level of Evidence: NA.",
journal = "Laryngoscope Investigative Otolaryngology, Laryngoscope Investigative Otolaryngology",
title = "Non-coding RNA and cholesteatoma",
doi = "10.1002/lio2.728"
}
Jovanović, I., Živković, M., Ješić, S.,& Stanković, A..Non-coding RNA and cholesteatoma. in Laryngoscope Investigative Otolaryngology.
https://doi.org/10.1002/lio2.728
Jovanović I, Živković M, Ješić S, Stanković A. Non-coding RNA and cholesteatoma. in Laryngoscope Investigative Otolaryngology..
doi:10.1002/lio2.728 .
Jovanović, Ivan, Živković, Maja, Ješić, Snežana, Stanković, Aleksandra, "Non-coding RNA and cholesteatoma" in Laryngoscope Investigative Otolaryngology,
https://doi.org/10.1002/lio2.728 . .

Properties of free-standing graphene oxide/silver nanowires films and effects of chemical reduction and gamma irradiation

Mišović, Aleksandra; Bajuk-Bogdanović, Danica V.; Kepić, Dejan; Pavlović, Vladimir B.; Huskić, Miroslav; Hasheminejad, Navid; Vuye, Cedric; Zorić, Nemanja; Jovanović, Svetlana P.

(2022)

TY  - JOUR
AU  - Mišović, Aleksandra
AU  - Bajuk-Bogdanović, Danica V.
AU  - Kepić, Dejan
AU  - Pavlović, Vladimir B.
AU  - Huskić, Miroslav
AU  - Hasheminejad, Navid
AU  - Vuye, Cedric
AU  - Zorić, Nemanja
AU  - Jovanović, Svetlana P.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10078
AB  - The need for stable, chemical resistant and conductive materials is on the rise in recent times. Graphene shows promising electrical conductivity and chemical stability, but the production of a continual, conductive layer is limited and expensive. Silver nanowires (AgNWs) are both conducive and economically viable, but they are sensitive to water and oxygen. In this study, graphene oxide (GO) and AgNWs were synthesized and combined in different mass ratios (3:1, 2.5:1.5, and 1:1) to obtain chemically stable composites with improved electrical properties. Composites were reduced using ascorbic acid. With the increase of AgNWs to GO mass ratio, the surface of the free-standing composite film improved: the root mean square roughness was lowered from 376 nm for GO to 168 nm for the composite with the mass ratio of GO:AgNWs 1:1, while the sheet resistance was lowered from 146 × 106 Ω/□ to 4 Ω/□. For the first time, the effects of gamma irradiation on the structure of the composites were studied. Doses of 15, 25, and 35 kGy were applied.
T2  - Synthetic Metals
T1  - Properties of free-standing graphene oxide/silver nanowires films and effects of chemical reduction and gamma irradiation
VL  - 283
SP  - 116980
DO  - 10.1016/j.synthmet.2021.116980
ER  - 
@article{
author = "Mišović, Aleksandra and Bajuk-Bogdanović, Danica V. and Kepić, Dejan and Pavlović, Vladimir B. and Huskić, Miroslav and Hasheminejad, Navid and Vuye, Cedric and Zorić, Nemanja and Jovanović, Svetlana P.",
year = "2022",
abstract = "The need for stable, chemical resistant and conductive materials is on the rise in recent times. Graphene shows promising electrical conductivity and chemical stability, but the production of a continual, conductive layer is limited and expensive. Silver nanowires (AgNWs) are both conducive and economically viable, but they are sensitive to water and oxygen. In this study, graphene oxide (GO) and AgNWs were synthesized and combined in different mass ratios (3:1, 2.5:1.5, and 1:1) to obtain chemically stable composites with improved electrical properties. Composites were reduced using ascorbic acid. With the increase of AgNWs to GO mass ratio, the surface of the free-standing composite film improved: the root mean square roughness was lowered from 376 nm for GO to 168 nm for the composite with the mass ratio of GO:AgNWs 1:1, while the sheet resistance was lowered from 146 × 106 Ω/□ to 4 Ω/□. For the first time, the effects of gamma irradiation on the structure of the composites were studied. Doses of 15, 25, and 35 kGy were applied.",
journal = "Synthetic Metals",
title = "Properties of free-standing graphene oxide/silver nanowires films and effects of chemical reduction and gamma irradiation",
volume = "283",
pages = "116980",
doi = "10.1016/j.synthmet.2021.116980"
}
Mišović, A., Bajuk-Bogdanović, D. V., Kepić, D., Pavlović, V. B., Huskić, M., Hasheminejad, N., Vuye, C., Zorić, N.,& Jovanović, S. P.. (2022). Properties of free-standing graphene oxide/silver nanowires films and effects of chemical reduction and gamma irradiation. in Synthetic Metals, 283, 116980.
https://doi.org/10.1016/j.synthmet.2021.116980
Mišović A, Bajuk-Bogdanović DV, Kepić D, Pavlović VB, Huskić M, Hasheminejad N, Vuye C, Zorić N, Jovanović SP. Properties of free-standing graphene oxide/silver nanowires films and effects of chemical reduction and gamma irradiation. in Synthetic Metals. 2022;283:116980.
doi:10.1016/j.synthmet.2021.116980 .
Mišović, Aleksandra, Bajuk-Bogdanović, Danica V., Kepić, Dejan, Pavlović, Vladimir B., Huskić, Miroslav, Hasheminejad, Navid, Vuye, Cedric, Zorić, Nemanja, Jovanović, Svetlana P., "Properties of free-standing graphene oxide/silver nanowires films and effects of chemical reduction and gamma irradiation" in Synthetic Metals, 283 (2022):116980,
https://doi.org/10.1016/j.synthmet.2021.116980 . .

Milovanović, Dubravka; Rajčić, Boris; Petronić, Sanja; Radulović, Aleksandra; Radak, Bojan; Gaković, Biljana; Zamfirescu, Marian; Albu, Catalina; Savović, Jelena

(2022)

TY  - JOUR
AU  - Milovanović, Dubravka
AU  - Rajčić, Boris
AU  - Petronić, Sanja
AU  - Radulović, Aleksandra
AU  - Radak, Bojan
AU  - Gaković, Biljana
AU  - Zamfirescu, Marian
AU  - Albu, Catalina
AU  - Savović, Jelena
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10116
AB  - The surface of a titanium-based alloy Ti6Al4V was subjected to modifications by a near-IR femtosecond Ti:Sapphire laser, emitting at 775 nm pulses of 200 fs duration, in single-pulse and multi-pulse regimes, with up to 400 accumulated pulses, and pulse energies ranging from 2.5 to 250 $$\upmu $$J. The whole range of induced effects is presented, from gentle ablation and pattern occurrence to substantial crater formation. Very observable laser-induced parallel periodic surface structures are reported, appearing both within the damage spot area, with low fluences, and at the peripheries of the craters, with higher fluences—but also on crater walls, and inside the crater structures. Damage threshold fluences $$({F}_{\mathrm{th}})$$and the incubation factor $$(\zeta )$$were also determined.
T2  - The European Physical Journal D
VL  - 76
IS  - 1
SP  - 2
DO  - 10.1140/epjd/s10053-021-00308-z
ER  - 
@article{
author = "Milovanović, Dubravka and Rajčić, Boris and Petronić, Sanja and Radulović, Aleksandra and Radak, Bojan and Gaković, Biljana and Zamfirescu, Marian and Albu, Catalina and Savović, Jelena",
year = "2022",
abstract = "The surface of a titanium-based alloy Ti6Al4V was subjected to modifications by a near-IR femtosecond Ti:Sapphire laser, emitting at 775 nm pulses of 200 fs duration, in single-pulse and multi-pulse regimes, with up to 400 accumulated pulses, and pulse energies ranging from 2.5 to 250 $$\upmu $$J. The whole range of induced effects is presented, from gentle ablation and pattern occurrence to substantial crater formation. Very observable laser-induced parallel periodic surface structures are reported, appearing both within the damage spot area, with low fluences, and at the peripheries of the craters, with higher fluences—but also on crater walls, and inside the crater structures. Damage threshold fluences $$({F}_{\mathrm{th}})$$and the incubation factor $$(\zeta )$$were also determined.",
journal = "The European Physical Journal D",
volume = "76",
number = "1",
pages = "2",
doi = "10.1140/epjd/s10053-021-00308-z"
}
Milovanović, D., Rajčić, B., Petronić, S., Radulović, A., Radak, B., Gaković, B., Zamfirescu, M., Albu, C.,& Savović, J.. (2022). in The European Physical Journal D, 76(1), 2.
https://doi.org/10.1140/epjd/s10053-021-00308-z
Milovanović D, Rajčić B, Petronić S, Radulović A, Radak B, Gaković B, Zamfirescu M, Albu C, Savović J. in The European Physical Journal D. 2022;76(1):2.
doi:10.1140/epjd/s10053-021-00308-z .
Milovanović, Dubravka, Rajčić, Boris, Petronić, Sanja, Radulović, Aleksandra, Radak, Bojan, Gaković, Biljana, Zamfirescu, Marian, Albu, Catalina, Savović, Jelena, in The European Physical Journal D, 76, no. 1 (2022):2,
https://doi.org/10.1140/epjd/s10053-021-00308-z . .

Tag Variants of LGALS-3 Containing Haplotype Block in Advanced Carotid Atherosclerosis

Đorđević, Ana; Živković, Maja; Končar, Igor; Stanković, Aleksandra; Kuveljić, Jovana; Đurić, Tamara

(2022)

TY  - JOUR
AU  - Đorđević, Ana
AU  - Živković, Maja
AU  - Končar, Igor
AU  - Stanković, Aleksandra
AU  - Kuveljić, Jovana
AU  - Đurić, Tamara
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10046
AB  - ObjectivesGalectin-3 affects a variety of biological processes. It is encoded by LGALS-3, located in unique haplotype block in Caucasians. Most of the studies regarding the gal-3 role in atherosclerosis are focused exclusively on protein/mRNA levels. Genetic analyses of LGALS-3 are scarce. We sought to thoroughly examine the genetic background of gal-3 and to analyze tag variants that cover more than 80% variability of the LGALS-3 containing hap-block in association with carotid plaque presence (CPP). According to Tagger server, rs4040064 G/T, rs11628437 G/A and rs7159490 C/T cover 82% (r2 > 0.8) of the genetic variance of this hap-block. Our aims were to investigate possible association of rs4040064, rs11628437 and rs7159490 haplotypes with CPP in patients with advanced carotid atherosclerosis (CA) and to analyze their possible effect on LGALS-3 mRNA expression in carotid plaques.Materials and methodsStudy group consisted of 468 patients and 296 controls. Rs4040064, rs11628437, rs7159490 and LGALS-3 mRNA expression were detected by TaqMan® technology.ResultsWe have found that haplotype TAC was associated with the cerebrovascular insult (CVI) occurrence (OR = 1.68, 95% CI = 1.09-2.58, p = 0.02), compared to the referent haplotype. OR was adjusted for hypertension, age and BMI. TAC also showed higher, but not statistically significant, LGALS-3 expression in carotid plaques.ConclusionsOur results suggest that rs4040064, rs11628437 and rs7159490 bear no association with CPP, neither they affect LGALS-3 mRNA in carotid plaques. However, we showed a significant association of haplotype TAC with the CVI occurrence in CA patients from Serbia. Replication and validation of our results are required.
T2  - Journal of Stroke and Cerebrovascular Diseases
T2  - Journal of Stroke and Cerebrovascular DiseasesJournal of Stroke and Cerebrovascular Diseases
T1  - Tag Variants of LGALS-3 Containing Haplotype Block in Advanced Carotid Atherosclerosis
VL  - 31
IS  - 1
SP  - 106212
DO  - 10.1016/j.jstrokecerebrovasdis.2021.106212
ER  - 
@article{
author = "Đorđević, Ana and Živković, Maja and Končar, Igor and Stanković, Aleksandra and Kuveljić, Jovana and Đurić, Tamara",
year = "2022",
abstract = "ObjectivesGalectin-3 affects a variety of biological processes. It is encoded by LGALS-3, located in unique haplotype block in Caucasians. Most of the studies regarding the gal-3 role in atherosclerosis are focused exclusively on protein/mRNA levels. Genetic analyses of LGALS-3 are scarce. We sought to thoroughly examine the genetic background of gal-3 and to analyze tag variants that cover more than 80% variability of the LGALS-3 containing hap-block in association with carotid plaque presence (CPP). According to Tagger server, rs4040064 G/T, rs11628437 G/A and rs7159490 C/T cover 82% (r2 > 0.8) of the genetic variance of this hap-block. Our aims were to investigate possible association of rs4040064, rs11628437 and rs7159490 haplotypes with CPP in patients with advanced carotid atherosclerosis (CA) and to analyze their possible effect on LGALS-3 mRNA expression in carotid plaques.Materials and methodsStudy group consisted of 468 patients and 296 controls. Rs4040064, rs11628437, rs7159490 and LGALS-3 mRNA expression were detected by TaqMan® technology.ResultsWe have found that haplotype TAC was associated with the cerebrovascular insult (CVI) occurrence (OR = 1.68, 95% CI = 1.09-2.58, p = 0.02), compared to the referent haplotype. OR was adjusted for hypertension, age and BMI. TAC also showed higher, but not statistically significant, LGALS-3 expression in carotid plaques.ConclusionsOur results suggest that rs4040064, rs11628437 and rs7159490 bear no association with CPP, neither they affect LGALS-3 mRNA in carotid plaques. However, we showed a significant association of haplotype TAC with the CVI occurrence in CA patients from Serbia. Replication and validation of our results are required.",
journal = "Journal of Stroke and Cerebrovascular Diseases, Journal of Stroke and Cerebrovascular DiseasesJournal of Stroke and Cerebrovascular Diseases",
title = "Tag Variants of LGALS-3 Containing Haplotype Block in Advanced Carotid Atherosclerosis",
volume = "31",
number = "1",
pages = "106212",
doi = "10.1016/j.jstrokecerebrovasdis.2021.106212"
}
Đorđević, A., Živković, M., Končar, I., Stanković, A., Kuveljić, J.,& Đurić, T.. (2022). Tag Variants of LGALS-3 Containing Haplotype Block in Advanced Carotid Atherosclerosis. in Journal of Stroke and Cerebrovascular Diseases, 31(1), 106212.
https://doi.org/10.1016/j.jstrokecerebrovasdis.2021.106212
Đorđević A, Živković M, Končar I, Stanković A, Kuveljić J, Đurić T. Tag Variants of LGALS-3 Containing Haplotype Block in Advanced Carotid Atherosclerosis. in Journal of Stroke and Cerebrovascular Diseases. 2022;31(1):106212.
doi:10.1016/j.jstrokecerebrovasdis.2021.106212 .
Đorđević, Ana, Živković, Maja, Končar, Igor, Stanković, Aleksandra, Kuveljić, Jovana, Đurić, Tamara, "Tag Variants of LGALS-3 Containing Haplotype Block in Advanced Carotid Atherosclerosis" in Journal of Stroke and Cerebrovascular Diseases, 31, no. 1 (2022):106212,
https://doi.org/10.1016/j.jstrokecerebrovasdis.2021.106212 . .

Low optical losses in plasmonic TiN thin films implanted with silver and gold

Novaković, Mirjana M.; Popović, Maja; Noga, Pavol; Vana, Dušan; Ronning, Carsten

(2022)

TY  - JOUR
AU  - Novaković, Mirjana M.
AU  - Popović, Maja
AU  - Noga, Pavol
AU  - Vana, Dušan
AU  - Ronning, Carsten
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10106
AB  - Titanium-nitride (TiN) is known as a very promising plasmonic material, which offers many advantages compared to conventional metals commonly used in practical devices. Despite many improvements, TiN still suffers from high losses in the near-infrared (NIR) spectral region, making it less suitable for real-life applications. In this study, we have investigated the effects of pure silver implanted as well as silver/gold co-implanted TiN thin films on their optical properties, which we analyzed by spectroscopic ellipsometry. We demonstrate that the presence of silver and gold drastically changes both the real and imaginary part of the dielectric function. The implanted films exhibit optical losses several times lower compared to as-deposited TiN. The changes are in particular more pronounced for the samples with Au/Ag co-implantations, reaching nearly the same optical values as those of pure gold and being only slightly larger than that of silver. Thus, such an optical tuning of TiN opens new horizons and provide high potential for its implementation into plasmonic applications.
T2  - Optical Materials
T1  - Low optical losses in plasmonic TiN thin films implanted with silver and gold
VL  - 123
SP  - 111936
DO  - 10.1016/j.optmat.2021.111936
ER  - 
@article{
author = "Novaković, Mirjana M. and Popović, Maja and Noga, Pavol and Vana, Dušan and Ronning, Carsten",
year = "2022",
abstract = "Titanium-nitride (TiN) is known as a very promising plasmonic material, which offers many advantages compared to conventional metals commonly used in practical devices. Despite many improvements, TiN still suffers from high losses in the near-infrared (NIR) spectral region, making it less suitable for real-life applications. In this study, we have investigated the effects of pure silver implanted as well as silver/gold co-implanted TiN thin films on their optical properties, which we analyzed by spectroscopic ellipsometry. We demonstrate that the presence of silver and gold drastically changes both the real and imaginary part of the dielectric function. The implanted films exhibit optical losses several times lower compared to as-deposited TiN. The changes are in particular more pronounced for the samples with Au/Ag co-implantations, reaching nearly the same optical values as those of pure gold and being only slightly larger than that of silver. Thus, such an optical tuning of TiN opens new horizons and provide high potential for its implementation into plasmonic applications.",
journal = "Optical Materials",
title = "Low optical losses in plasmonic TiN thin films implanted with silver and gold",
volume = "123",
pages = "111936",
doi = "10.1016/j.optmat.2021.111936"
}
Novaković, M. M., Popović, M., Noga, P., Vana, D.,& Ronning, C.. (2022). Low optical losses in plasmonic TiN thin films implanted with silver and gold. in Optical Materials, 123, 111936.
https://doi.org/10.1016/j.optmat.2021.111936
Novaković MM, Popović M, Noga P, Vana D, Ronning C. Low optical losses in plasmonic TiN thin films implanted with silver and gold. in Optical Materials. 2022;123:111936.
doi:10.1016/j.optmat.2021.111936 .
Novaković, Mirjana M., Popović, Maja, Noga, Pavol, Vana, Dušan, Ronning, Carsten, "Low optical losses in plasmonic TiN thin films implanted with silver and gold" in Optical Materials, 123 (2022):111936,
https://doi.org/10.1016/j.optmat.2021.111936 . .

Stimuli-responsive copolymeric hydrogels based on oligo(ethylene glycol) dimethacrylate for biomedical applications: An optimisation study of pH and thermoresponsive behaviour

Krstić, Marko Z.; Rogić Miladinović, Z.; Barudžija, Tanja S.; Mladenović, Aleksandar R.; Suljovrujić, Edin H.

(2022)

TY  - JOUR
AU  - Krstić, Marko Z.
AU  - Rogić Miladinović, Z.
AU  - Barudžija, Tanja S.
AU  - Mladenović, Aleksandar R.
AU  - Suljovrujić, Edin H.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10097
AB  - Di(meth)acrylate (D(M)A) systems with pendant oligo(ethylene glycol) (OEG) chains are promising biomedical candidates. Homopolymeric P(OEG)D(M)A hydrogels have significant thermoresponsiveness demonstrated mainly at elevated temperatures which makes this class of materials unsuitable for bio-applications. Copolymerisation with less hydrophilic 2-hydroxyethyl methacrylate (HEMA) was performed in an effort to shift volume phase transition (VPT) closer to physiological temperatures and to widen their application as thermoresponsive materials. Various monomer-solvent mixtures, consisting of different mole ratios of OEGDMA and HEMA monomers (100/0, 50/50, 27.5/72.5, and 12.5/87.5) and water/ethanol as solvent, were exposed to gamma radiation up to 6, 12, 25, and 50 kGy. Furthermore, in an attempt to obtain multi- (thermo- and pH-) responsive hydrogels for biomedical applications new P(OEGDMA/HEMA/IA) terpolymers containing a small share (2.5, and 5 wt%) of itaconic acid (IA) were synthesised. The successful fabrication of the hydrogels was confirmed by gel measurements and FTIR spectroscopy. Swelling measurements indicated that obtained networks possessed tuneable thermal behaviour and swelling properties which could be significantly altered by hydrogel composition. The porous architecture was investigated using SEM, confirming swelling results. Cytotoxicity revealed relatively high cell viability for all hydrogels, indicating satisfactory in vitro biocompatibility. Therefore, new OEGDMA based hydrogels showed potential for biomedical applications.
T2  - Reactive and Functional Polymers
T1  - Stimuli-responsive copolymeric hydrogels based on oligo(ethylene glycol) dimethacrylate for biomedical applications: An optimisation study of pH and thermoresponsive behaviour
VL  - 170
SP  - 105140
DO  - 10.1016/j.reactfunctpolym.2021.105140
ER  - 
@article{
author = "Krstić, Marko Z. and Rogić Miladinović, Z. and Barudžija, Tanja S. and Mladenović, Aleksandar R. and Suljovrujić, Edin H.",
year = "2022",
abstract = "Di(meth)acrylate (D(M)A) systems with pendant oligo(ethylene glycol) (OEG) chains are promising biomedical candidates. Homopolymeric P(OEG)D(M)A hydrogels have significant thermoresponsiveness demonstrated mainly at elevated temperatures which makes this class of materials unsuitable for bio-applications. Copolymerisation with less hydrophilic 2-hydroxyethyl methacrylate (HEMA) was performed in an effort to shift volume phase transition (VPT) closer to physiological temperatures and to widen their application as thermoresponsive materials. Various monomer-solvent mixtures, consisting of different mole ratios of OEGDMA and HEMA monomers (100/0, 50/50, 27.5/72.5, and 12.5/87.5) and water/ethanol as solvent, were exposed to gamma radiation up to 6, 12, 25, and 50 kGy. Furthermore, in an attempt to obtain multi- (thermo- and pH-) responsive hydrogels for biomedical applications new P(OEGDMA/HEMA/IA) terpolymers containing a small share (2.5, and 5 wt%) of itaconic acid (IA) were synthesised. The successful fabrication of the hydrogels was confirmed by gel measurements and FTIR spectroscopy. Swelling measurements indicated that obtained networks possessed tuneable thermal behaviour and swelling properties which could be significantly altered by hydrogel composition. The porous architecture was investigated using SEM, confirming swelling results. Cytotoxicity revealed relatively high cell viability for all hydrogels, indicating satisfactory in vitro biocompatibility. Therefore, new OEGDMA based hydrogels showed potential for biomedical applications.",
journal = "Reactive and Functional Polymers",
title = "Stimuli-responsive copolymeric hydrogels based on oligo(ethylene glycol) dimethacrylate for biomedical applications: An optimisation study of pH and thermoresponsive behaviour",
volume = "170",
pages = "105140",
doi = "10.1016/j.reactfunctpolym.2021.105140"
}
Krstić, M. Z., Rogić Miladinović, Z., Barudžija, T. S., Mladenović, A. R.,& Suljovrujić, E. H.. (2022). Stimuli-responsive copolymeric hydrogels based on oligo(ethylene glycol) dimethacrylate for biomedical applications: An optimisation study of pH and thermoresponsive behaviour. in Reactive and Functional Polymers, 170, 105140.
https://doi.org/10.1016/j.reactfunctpolym.2021.105140
Krstić MZ, Rogić Miladinović Z, Barudžija TS, Mladenović AR, Suljovrujić EH. Stimuli-responsive copolymeric hydrogels based on oligo(ethylene glycol) dimethacrylate for biomedical applications: An optimisation study of pH and thermoresponsive behaviour. in Reactive and Functional Polymers. 2022;170:105140.
doi:10.1016/j.reactfunctpolym.2021.105140 .
Krstić, Marko Z., Rogić Miladinović, Z., Barudžija, Tanja S., Mladenović, Aleksandar R., Suljovrujić, Edin H., "Stimuli-responsive copolymeric hydrogels based on oligo(ethylene glycol) dimethacrylate for biomedical applications: An optimisation study of pH and thermoresponsive behaviour" in Reactive and Functional Polymers, 170 (2022):105140,
https://doi.org/10.1016/j.reactfunctpolym.2021.105140 . .

A comparison of alpha-particle and gamma-ray spectrometry methods for determination of 235U, 238U and 226Ra activity concentration in samples of coal, slag and fly-ash

Vukanac, Ivana; Šešlak, Bojan Ž.; Kandić, Aleksandar; Čeliković, Igor T.; Mladenović-Nikolić, Nataša; Milanović, Tamara; Obradović, Zorica; Đurašević, Mirjana

(2022)

TY  - JOUR
AU  - Vukanac, Ivana
AU  - Šešlak, Bojan Ž.
AU  - Kandić, Aleksandar
AU  - Čeliković, Igor T.
AU  - Mladenović-Nikolić, Nataša
AU  - Milanović, Tamara
AU  - Obradović, Zorica
AU  - Đurašević, Mirjana
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10096
AB  - In order to compare alpha-particle and gamma-ray spectrometry, the activity concentrations of 235U, 238U and 226Ra in samples of coal, slag and fly-ash from the thermal power plant “Nikola Tesla A”, Serbia, were determined by these two methods. Methods were compared and discussed from the point of view of its precision, difficulty to apply and complexity. Gamma-ray spectrometry was performed with HPGe (High Purity Germanium) spectrometer, while alpha activity was measured by PIPS (Passivated Implanted Planar Silicon) detector. For the alpha-particle spectrometry, the chemical procedures applied were chromatographic resin extraction for uranium isotopes and micro-coprecipitation for 226Ra. Thin alpha sources were prepared by electrodeposition and filtration through polypropylene membrane filter for uranium determination, while filtration technique was performed for radium sources. For the evaluation of the statistical difference between individual measurement results obtained by application of two methods Z - test was used. In order to evaluate the difference between two methods used, paired samples t-test and F-test were applied. Results show that there is no statistical difference between two methods used and that gamma-ray spectrometry is a valid alternative to time consuming alpha spectrometry.
T2  - Radiation Physics and Chemistry
T1  - A comparison of alpha-particle and gamma-ray spectrometry methods for determination of 235U, 238U and 226Ra activity concentration in samples of coal, slag and fly-ash
VL  - 193
SP  - 109933
DO  - 10.1016/j.radphyschem.2021.109933
ER  - 
@article{
author = "Vukanac, Ivana and Šešlak, Bojan Ž. and Kandić, Aleksandar and Čeliković, Igor T. and Mladenović-Nikolić, Nataša and Milanović, Tamara and Obradović, Zorica and Đurašević, Mirjana",
year = "2022",
abstract = "In order to compare alpha-particle and gamma-ray spectrometry, the activity concentrations of 235U, 238U and 226Ra in samples of coal, slag and fly-ash from the thermal power plant “Nikola Tesla A”, Serbia, were determined by these two methods. Methods were compared and discussed from the point of view of its precision, difficulty to apply and complexity. Gamma-ray spectrometry was performed with HPGe (High Purity Germanium) spectrometer, while alpha activity was measured by PIPS (Passivated Implanted Planar Silicon) detector. For the alpha-particle spectrometry, the chemical procedures applied were chromatographic resin extraction for uranium isotopes and micro-coprecipitation for 226Ra. Thin alpha sources were prepared by electrodeposition and filtration through polypropylene membrane filter for uranium determination, while filtration technique was performed for radium sources. For the evaluation of the statistical difference between individual measurement results obtained by application of two methods Z - test was used. In order to evaluate the difference between two methods used, paired samples t-test and F-test were applied. Results show that there is no statistical difference between two methods used and that gamma-ray spectrometry is a valid alternative to time consuming alpha spectrometry.",
journal = "Radiation Physics and Chemistry",
title = "A comparison of alpha-particle and gamma-ray spectrometry methods for determination of 235U, 238U and 226Ra activity concentration in samples of coal, slag and fly-ash",
volume = "193",
pages = "109933",
doi = "10.1016/j.radphyschem.2021.109933"
}
Vukanac, I., Šešlak, B. Ž., Kandić, A., Čeliković, I. T., Mladenović-Nikolić, N., Milanović, T., Obradović, Z.,& Đurašević, M.. (2022). A comparison of alpha-particle and gamma-ray spectrometry methods for determination of 235U, 238U and 226Ra activity concentration in samples of coal, slag and fly-ash. in Radiation Physics and Chemistry, 193, 109933.
https://doi.org/10.1016/j.radphyschem.2021.109933
Vukanac I, Šešlak BŽ, Kandić A, Čeliković IT, Mladenović-Nikolić N, Milanović T, Obradović Z, Đurašević M. A comparison of alpha-particle and gamma-ray spectrometry methods for determination of 235U, 238U and 226Ra activity concentration in samples of coal, slag and fly-ash. in Radiation Physics and Chemistry. 2022;193:109933.
doi:10.1016/j.radphyschem.2021.109933 .
Vukanac, Ivana, Šešlak, Bojan Ž., Kandić, Aleksandar, Čeliković, Igor T., Mladenović-Nikolić, Nataša, Milanović, Tamara, Obradović, Zorica, Đurašević, Mirjana, "A comparison of alpha-particle and gamma-ray spectrometry methods for determination of 235U, 238U and 226Ra activity concentration in samples of coal, slag and fly-ash" in Radiation Physics and Chemistry, 193 (2022):109933,
https://doi.org/10.1016/j.radphyschem.2021.109933 . .

Development and Validation of an Open-Source Finite-Volume Method Solver for Viscoplastic Flows

Mirkov, Nikola S.; Ouyahia, Seif Eddine; Lahlou, Sara; Pezo, Milada L.; Jovanović, Rastko D.

(2022)

TY  - CHAP
AU  - Mirkov, Nikola S.
AU  - Ouyahia, Seif Eddine
AU  - Lahlou, Sara
AU  - Pezo, Milada L.
AU  - Jovanović, Rastko D.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10065
AB  - In the present paper, we discuss implementation details of a free and open-source numerical solver based on the finite volume method for numerical simulation of viscoplastic non-Newtonian fluids. In addition to the fact that they are involved in many industrial applications, both their physical properties and their rheological behavior make them challenging for numerical simulation. Viscoplastic fluids are known to behave as solid unless the shear stress reaches a critical level, known as yield-stress, beyond which they behave as liquid. In most cases, both yielded and unyielded regions coexist in the fluid domain. In mathematical model of viscoplastic fluid, the constitutive equation is a non-differentiable function. This is often overcome by using the approximate constitutive equation that has a regularized form, e.g. the Papanastasiou regularization model. Using the same approach, we assess the influence of regularization parameters on simulation convergence and results accuracy. In this study, we give implementation details of viscoplastic fluid models in freeCappuccino open-source Computational Fluid Dynamics code. Moreover, we perform validation on several well known benchmark cases and compare proposed approach with those existing in published literature. We also perform a parametric analysis and show the effect of Reynolds and Bingham numbers on the extent of the yielded regions. Conclusions of the study have relevance in practical application of computational fluid dynamics to viscoplastic fluids in particular and to non-Newtonian fluids in general. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.
T2  - Lecture Notes in Networks and Systems
T1  - Development and Validation of an Open-Source Finite-Volume Method Solver for Viscoplastic Flows
VL  - 323
SP  - 223
EP  - 238
DO  - 10.1007/978-3-030-86009-7_12
ER  - 
@inbook{
author = "Mirkov, Nikola S. and Ouyahia, Seif Eddine and Lahlou, Sara and Pezo, Milada L. and Jovanović, Rastko D.",
year = "2022",
abstract = "In the present paper, we discuss implementation details of a free and open-source numerical solver based on the finite volume method for numerical simulation of viscoplastic non-Newtonian fluids. In addition to the fact that they are involved in many industrial applications, both their physical properties and their rheological behavior make them challenging for numerical simulation. Viscoplastic fluids are known to behave as solid unless the shear stress reaches a critical level, known as yield-stress, beyond which they behave as liquid. In most cases, both yielded and unyielded regions coexist in the fluid domain. In mathematical model of viscoplastic fluid, the constitutive equation is a non-differentiable function. This is often overcome by using the approximate constitutive equation that has a regularized form, e.g. the Papanastasiou regularization model. Using the same approach, we assess the influence of regularization parameters on simulation convergence and results accuracy. In this study, we give implementation details of viscoplastic fluid models in freeCappuccino open-source Computational Fluid Dynamics code. Moreover, we perform validation on several well known benchmark cases and compare proposed approach with those existing in published literature. We also perform a parametric analysis and show the effect of Reynolds and Bingham numbers on the extent of the yielded regions. Conclusions of the study have relevance in practical application of computational fluid dynamics to viscoplastic fluids in particular and to non-Newtonian fluids in general. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.",
journal = "Lecture Notes in Networks and Systems",
booktitle = "Development and Validation of an Open-Source Finite-Volume Method Solver for Viscoplastic Flows",
volume = "323",
pages = "223-238",
doi = "10.1007/978-3-030-86009-7_12"
}
Mirkov, N. S., Ouyahia, S. E., Lahlou, S., Pezo, M. L.,& Jovanović, R. D.. (2022). Development and Validation of an Open-Source Finite-Volume Method Solver for Viscoplastic Flows. in Lecture Notes in Networks and Systems, 323, 223-238.
https://doi.org/10.1007/978-3-030-86009-7_12
Mirkov NS, Ouyahia SE, Lahlou S, Pezo ML, Jovanović RD. Development and Validation of an Open-Source Finite-Volume Method Solver for Viscoplastic Flows. in Lecture Notes in Networks and Systems. 2022;323:223-238.
doi:10.1007/978-3-030-86009-7_12 .
Mirkov, Nikola S., Ouyahia, Seif Eddine, Lahlou, Sara, Pezo, Milada L., Jovanović, Rastko D., "Development and Validation of an Open-Source Finite-Volume Method Solver for Viscoplastic Flows" in Lecture Notes in Networks and Systems, 323 (2022):223-238,
https://doi.org/10.1007/978-3-030-86009-7_12 . .

Simple and effective one-step production of high-quality mesoporous pyrolytic char from waste tires: Rhodamine B adsorption kinetics and density functional theory (DFT) study

Pijović, Milena; Manić, Nebojša; Vasić Anićijević, Dragana D.; Krstić, Aleksandar; Mitrić, Miodrag; Matić, Tamara; Janković, Bojan

(2022)

TY  - JOUR
AU  - Pijović, Milena
AU  - Manić, Nebojša
AU  - Vasić Anićijević, Dragana D.
AU  - Krstić, Aleksandar
AU  - Mitrić, Miodrag
AU  - Matić, Tamara
AU  - Janković, Bojan
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10077
AB  - Pyrolytic tire (PT) chars were first produced from waste car tires (WCT) through carbonization process at 800 °C, for different retention times. Then, best PT-char sample by its physicochemical properties (WCT 800(1 h)) was further tested for its ability to adsorb Rhodamine B (RhB) dye from aqueous solutions. Structural characterization of synthesized material showed existence of graphene-based material, with average pore diameter of 22.8 nm and specific surface area of 55.8 m2·g−1. Obtained carbon material meets specifications of commercial carbon black (CB). The yield of 33.6% of CB recovered has been achieved. Under the optimal conditions, 99.57% of RhB was removed. Adsorption of RhB obeys pseudo second-order model and Langmuir isotherm model. DFT (the density functional theory) was revealed that effective bonding of RhB onto WCT 800 originates from π-electron interactions with aromatic moieties and chemical (or at least the electrostatic) interactions, between positive nitrogen and electron-rich surface groups.
T2  - Diamond and Related Materials
T1  - Simple and effective one-step production of high-quality mesoporous pyrolytic char from waste tires: Rhodamine B adsorption kinetics and density functional theory (DFT) study
VL  - 121
SP  - 108768
DO  - 10.1016/j.diamond.2021.108768
ER  - 
@article{
author = "Pijović, Milena and Manić, Nebojša and Vasić Anićijević, Dragana D. and Krstić, Aleksandar and Mitrić, Miodrag and Matić, Tamara and Janković, Bojan",
year = "2022",
abstract = "Pyrolytic tire (PT) chars were first produced from waste car tires (WCT) through carbonization process at 800 °C, for different retention times. Then, best PT-char sample by its physicochemical properties (WCT 800(1 h)) was further tested for its ability to adsorb Rhodamine B (RhB) dye from aqueous solutions. Structural characterization of synthesized material showed existence of graphene-based material, with average pore diameter of 22.8 nm and specific surface area of 55.8 m2·g−1. Obtained carbon material meets specifications of commercial carbon black (CB). The yield of 33.6% of CB recovered has been achieved. Under the optimal conditions, 99.57% of RhB was removed. Adsorption of RhB obeys pseudo second-order model and Langmuir isotherm model. DFT (the density functional theory) was revealed that effective bonding of RhB onto WCT 800 originates from π-electron interactions with aromatic moieties and chemical (or at least the electrostatic) interactions, between positive nitrogen and electron-rich surface groups.",
journal = "Diamond and Related Materials",
title = "Simple and effective one-step production of high-quality mesoporous pyrolytic char from waste tires: Rhodamine B adsorption kinetics and density functional theory (DFT) study",
volume = "121",
pages = "108768",
doi = "10.1016/j.diamond.2021.108768"
}
Pijović, M., Manić, N., Vasić Anićijević, D. D., Krstić, A., Mitrić, M., Matić, T.,& Janković, B.. (2022). Simple and effective one-step production of high-quality mesoporous pyrolytic char from waste tires: Rhodamine B adsorption kinetics and density functional theory (DFT) study. in Diamond and Related Materials, 121, 108768.
https://doi.org/10.1016/j.diamond.2021.108768
Pijović M, Manić N, Vasić Anićijević DD, Krstić A, Mitrić M, Matić T, Janković B. Simple and effective one-step production of high-quality mesoporous pyrolytic char from waste tires: Rhodamine B adsorption kinetics and density functional theory (DFT) study. in Diamond and Related Materials. 2022;121:108768.
doi:10.1016/j.diamond.2021.108768 .
Pijović, Milena, Manić, Nebojša, Vasić Anićijević, Dragana D., Krstić, Aleksandar, Mitrić, Miodrag, Matić, Tamara, Janković, Bojan, "Simple and effective one-step production of high-quality mesoporous pyrolytic char from waste tires: Rhodamine B adsorption kinetics and density functional theory (DFT) study" in Diamond and Related Materials, 121 (2022):108768,
https://doi.org/10.1016/j.diamond.2021.108768 . .

Laser-induced breakdown spectroscopy analysis of water solutions deposited on PTFE surface: Influence of copper oxide nanoparticles and NELIBS effect

Kiris, Vasili; Savović, Jelena; Nevar, Alena; Kuzmanović, Miroslav; Nedelko, Mikhail; Ranković, Dragan; Tarasenko, Nikolai

(2022)

TY  - JOUR
AU  - Kiris, Vasili
AU  - Savović, Jelena
AU  - Nevar, Alena
AU  - Kuzmanović, Miroslav
AU  - Nedelko, Mikhail
AU  - Ranković, Dragan
AU  - Tarasenko, Nikolai
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10059
AB  - The analytical potential of LIBS for the analysis of liquid solutions was evaluated using two experimental setups, one based on a TEA CO2 laser and the other in which Nd:YAG laser was used. Polytetrafluoroethylene (PTFE) was used as a substrate on which a 10 μL drop of analyte solutions with different concentrations of analyte elements, Be, Cr, Ni, Co, Pb, Tl, and V, were deposited and dried. The samples were deposited either directly on the PTFE or over the pre-deposited layer of copper oxide nanoparticles to study the influence of nanoparticles (NPs) on the ablation and plasma excitation. The obtained results imply that the presence of Cu oxide NPs does not significantly affect the analytical performance of LIBS based on TEA CO2 laser for analysis of solutions. At the same time, it was shown that plasma created by TEA CO2 laser radiation efficiently excited ablated material, making metal elements detectable in the sub-ppm concentration range. On the other hand, Cu oxide NPs significantly influence the formation and the analytical properties of plasma induced by Nd:YAG laser. Without the presence of NPs, the intensities of analyte lines were very low, unsuitable for spectrochemical analysis. At the optimal surface concentration of NPs, 0.36 mg/cm2, the intensity of analyte lines was increased more than ten times. Limits of detection of Be and Cr were 5.3 ppb and 33 ppb, with good linearity of curves of growth.
T2  - Spectrochimica Acta Part B: Atomic Spectroscopy
T1  - Laser-induced breakdown spectroscopy analysis of water solutions deposited on PTFE surface: Influence of copper oxide nanoparticles and NELIBS effect
VL  - 187
SP  - 106333
DO  - 10.1016/j.sab.2021.106333
ER  - 
@article{
author = "Kiris, Vasili and Savović, Jelena and Nevar, Alena and Kuzmanović, Miroslav and Nedelko, Mikhail and Ranković, Dragan and Tarasenko, Nikolai",
year = "2022",
abstract = "The analytical potential of LIBS for the analysis of liquid solutions was evaluated using two experimental setups, one based on a TEA CO2 laser and the other in which Nd:YAG laser was used. Polytetrafluoroethylene (PTFE) was used as a substrate on which a 10 μL drop of analyte solutions with different concentrations of analyte elements, Be, Cr, Ni, Co, Pb, Tl, and V, were deposited and dried. The samples were deposited either directly on the PTFE or over the pre-deposited layer of copper oxide nanoparticles to study the influence of nanoparticles (NPs) on the ablation and plasma excitation. The obtained results imply that the presence of Cu oxide NPs does not significantly affect the analytical performance of LIBS based on TEA CO2 laser for analysis of solutions. At the same time, it was shown that plasma created by TEA CO2 laser radiation efficiently excited ablated material, making metal elements detectable in the sub-ppm concentration range. On the other hand, Cu oxide NPs significantly influence the formation and the analytical properties of plasma induced by Nd:YAG laser. Without the presence of NPs, the intensities of analyte lines were very low, unsuitable for spectrochemical analysis. At the optimal surface concentration of NPs, 0.36 mg/cm2, the intensity of analyte lines was increased more than ten times. Limits of detection of Be and Cr were 5.3 ppb and 33 ppb, with good linearity of curves of growth.",
journal = "Spectrochimica Acta Part B: Atomic Spectroscopy",
title = "Laser-induced breakdown spectroscopy analysis of water solutions deposited on PTFE surface: Influence of copper oxide nanoparticles and NELIBS effect",
volume = "187",
pages = "106333",
doi = "10.1016/j.sab.2021.106333"
}
Kiris, V., Savović, J., Nevar, A., Kuzmanović, M., Nedelko, M., Ranković, D.,& Tarasenko, N.. (2022). Laser-induced breakdown spectroscopy analysis of water solutions deposited on PTFE surface: Influence of copper oxide nanoparticles and NELIBS effect. in Spectrochimica Acta Part B: Atomic Spectroscopy, 187, 106333.
https://doi.org/10.1016/j.sab.2021.106333
Kiris V, Savović J, Nevar A, Kuzmanović M, Nedelko M, Ranković D, Tarasenko N. Laser-induced breakdown spectroscopy analysis of water solutions deposited on PTFE surface: Influence of copper oxide nanoparticles and NELIBS effect. in Spectrochimica Acta Part B: Atomic Spectroscopy. 2022;187:106333.
doi:10.1016/j.sab.2021.106333 .
Kiris, Vasili, Savović, Jelena, Nevar, Alena, Kuzmanović, Miroslav, Nedelko, Mikhail, Ranković, Dragan, Tarasenko, Nikolai, "Laser-induced breakdown spectroscopy analysis of water solutions deposited on PTFE surface: Influence of copper oxide nanoparticles and NELIBS effect" in Spectrochimica Acta Part B: Atomic Spectroscopy, 187 (2022):106333,
https://doi.org/10.1016/j.sab.2021.106333 . .

TEA CO2 Laser – Polymethyl Methacrylate Interaction: LIBS Hydrogen Analysis

Trtica, Milan; Kuzmanović, Miroslav; Savović, Jelena; Ranković, Dragan

(2022)

TY  - JOUR
AU  - Trtica, Milan
AU  - Kuzmanović, Miroslav
AU  - Savović, Jelena
AU  - Ranković, Dragan
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9972
AB  - The interaction of a Transversely Excited Atmospheric (TEA) CO2 laser with a polymer polymethyl methacrylate (PMMA) sample in a vacuum ambiance was studied. The main goal was to demonstrate the feasibility of laser-induced breakdown spectroscopy (LIBS) to detect hydrogen. The generation of plasma over the PMMA surface, using a low laser intensity of ∼ 48 MW/cm2 and fluence of ∼ 16.5 J/cm2, required the application of a metal sub-target. Besides hydrogen, the recorded spectra were dominated by atomic lines of carbon and oxygen and band emission of the C2 and CN molecules. The electron number density and temperature (ionic, vibrational, and rotational) were evaluated to characterize the laser-induced plasma. In addition, PMMA micro-damages (diameter ∼ 45 µm) created by a multipulse laser ablation could find potential applications in sensor technologies.
T2  - Applied Surface Science
T1  - TEA CO2 Laser – Polymethyl Methacrylate Interaction: LIBS Hydrogen Analysis
VL  - 572
SP  - 151424
DO  - 10.1016/j.apsusc.2021.151424
ER  - 
@article{
author = "Trtica, Milan and Kuzmanović, Miroslav and Savović, Jelena and Ranković, Dragan",
year = "2022",
abstract = "The interaction of a Transversely Excited Atmospheric (TEA) CO2 laser with a polymer polymethyl methacrylate (PMMA) sample in a vacuum ambiance was studied. The main goal was to demonstrate the feasibility of laser-induced breakdown spectroscopy (LIBS) to detect hydrogen. The generation of plasma over the PMMA surface, using a low laser intensity of ∼ 48 MW/cm2 and fluence of ∼ 16.5 J/cm2, required the application of a metal sub-target. Besides hydrogen, the recorded spectra were dominated by atomic lines of carbon and oxygen and band emission of the C2 and CN molecules. The electron number density and temperature (ionic, vibrational, and rotational) were evaluated to characterize the laser-induced plasma. In addition, PMMA micro-damages (diameter ∼ 45 µm) created by a multipulse laser ablation could find potential applications in sensor technologies.",
journal = "Applied Surface Science",
title = "TEA CO2 Laser – Polymethyl Methacrylate Interaction: LIBS Hydrogen Analysis",
volume = "572",
pages = "151424",
doi = "10.1016/j.apsusc.2021.151424"
}
Trtica, M., Kuzmanović, M., Savović, J.,& Ranković, D.. (2022). TEA CO2 Laser – Polymethyl Methacrylate Interaction: LIBS Hydrogen Analysis. in Applied Surface Science, 572, 151424.
https://doi.org/10.1016/j.apsusc.2021.151424
Trtica M, Kuzmanović M, Savović J, Ranković D. TEA CO2 Laser – Polymethyl Methacrylate Interaction: LIBS Hydrogen Analysis. in Applied Surface Science. 2022;572:151424.
doi:10.1016/j.apsusc.2021.151424 .
Trtica, Milan, Kuzmanović, Miroslav, Savović, Jelena, Ranković, Dragan, "TEA CO2 Laser – Polymethyl Methacrylate Interaction: LIBS Hydrogen Analysis" in Applied Surface Science, 572 (2022):151424,
https://doi.org/10.1016/j.apsusc.2021.151424 . .

Shedding Light on Graphene Quantum Dots: Key Synthetic Strategies, Characterization Tools, and Cutting-Edge Applications

Dorontić, Slađana; Jovanović, Svetlana P.; Bonasera, Aurelio

(2021)

TY  - JOUR
AU  - Dorontić, Slađana
AU  - Jovanović, Svetlana P.
AU  - Bonasera, Aurelio
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10040
AB  - During the last 20 years, the scientific community has shown growing interest towards carbonaceous nanomaterials due to their appealing mechanical, thermal, and optical features, depending on the specific nanoforms. Among these, graphene quantum dots (GQDs) recently emerged as one of the most promising nanomaterials due to their outstanding electrical properties, chemical stability, and intense and tunable photoluminescence, as it is witnessed by a booming number of reported applications, ranging from the biological field to the photovoltaic market. To date, a plethora of synthetic protocols have been investigated to modulate the portfolio of features that GQDs possess and to facilitate the use of these materials for target applications. Considering the number of publications and the rapid evolution of this flourishing field of research, this review aims at providing a broad overview of the most widely established synthetic protocols and offering a detailed review of some specific applications that are attracting researchers’ interest.
T2  - Materials
T1  - Shedding Light on Graphene Quantum Dots: Key Synthetic Strategies, Characterization Tools, and Cutting-Edge Applications
VL  - 14
IS  - 20
SP  - 6153
DO  - 10.3390/ma14206153
ER  - 
@article{
author = "Dorontić, Slađana and Jovanović, Svetlana P. and Bonasera, Aurelio",
year = "2021",
abstract = "During the last 20 years, the scientific community has shown growing interest towards carbonaceous nanomaterials due to their appealing mechanical, thermal, and optical features, depending on the specific nanoforms. Among these, graphene quantum dots (GQDs) recently emerged as one of the most promising nanomaterials due to their outstanding electrical properties, chemical stability, and intense and tunable photoluminescence, as it is witnessed by a booming number of reported applications, ranging from the biological field to the photovoltaic market. To date, a plethora of synthetic protocols have been investigated to modulate the portfolio of features that GQDs possess and to facilitate the use of these materials for target applications. Considering the number of publications and the rapid evolution of this flourishing field of research, this review aims at providing a broad overview of the most widely established synthetic protocols and offering a detailed review of some specific applications that are attracting researchers’ interest.",
journal = "Materials",
title = "Shedding Light on Graphene Quantum Dots: Key Synthetic Strategies, Characterization Tools, and Cutting-Edge Applications",
volume = "14",
number = "20",
pages = "6153",
doi = "10.3390/ma14206153"
}
Dorontić, S., Jovanović, S. P.,& Bonasera, A.. (2021). Shedding Light on Graphene Quantum Dots: Key Synthetic Strategies, Characterization Tools, and Cutting-Edge Applications. in Materials, 14(20), 6153.
https://doi.org/10.3390/ma14206153
Dorontić S, Jovanović SP, Bonasera A. Shedding Light on Graphene Quantum Dots: Key Synthetic Strategies, Characterization Tools, and Cutting-Edge Applications. in Materials. 2021;14(20):6153.
doi:10.3390/ma14206153 .
Dorontić, Slađana, Jovanović, Svetlana P., Bonasera, Aurelio, "Shedding Light on Graphene Quantum Dots: Key Synthetic Strategies, Characterization Tools, and Cutting-Edge Applications" in Materials, 14, no. 20 (2021):6153,
https://doi.org/10.3390/ma14206153 . .

Graphene quantum dot antioxidant and proautophagic actions protect SH-SY5Y neuroblastoma cells from oxidative stress-mediated apoptotic death

Krunić, Matija; Ristić, Biljana; Bošnjak, Mihajlo; Paunović, Verica; Tovilović-Kovačević, Gordana; Zogović, Nevena; Mirčić, Aleksandar; Marković, Zoran; Todorović-Marković, Biljana; Jovanović, Svetlana P.; Kleut, Duška; Mojović, Miloš; Nakarada, Đura; Marković, Olivera; Vuković, Irena; Harhaji-Trajković, Ljubica; Trajković, Vladimir

(2021)

TY  - JOUR
AU  - Krunić, Matija
AU  - Ristić, Biljana
AU  - Bošnjak, Mihajlo
AU  - Paunović, Verica
AU  - Tovilović-Kovačević, Gordana
AU  - Zogović, Nevena
AU  - Mirčić, Aleksandar
AU  - Marković, Zoran
AU  - Todorović-Marković, Biljana
AU  - Jovanović, Svetlana P.
AU  - Kleut, Duška
AU  - Mojović, Miloš
AU  - Nakarada, Đura
AU  - Marković, Olivera
AU  - Vuković, Irena
AU  - Harhaji-Trajković, Ljubica
AU  - Trajković, Vladimir
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9980
AB  - We investigated the ability of graphene quantum dot (GQD) nanoparticles to protect SH-SY5Y human neuroblastoma cells from oxidative/nitrosative stress induced by iron-nitrosyl complex sodium nitroprusside (SNP).GQD reduced SNP cytotoxicity by preventing mitochondrial depolarization, caspase-2 activation, and subsequent apoptotic death. Although GQD diminished the levels of nitric oxide (NO) in SNP-exposed cells, NO scavengers displayed only a slight protective effect, suggesting that NO quenching was not the main protective mechanism of GQD. GQD also reduced SNP-triggered increase in the intracellular levels of hydroxyl radical (•OH), superoxide anion (O2•- ), and lipid peroxidation. Nonselective antioxidants, •OH scavenging, and iron chelators, but not superoxide dismutase, mimicked GQD cytoprotective activity, indicating that GQD protect cells by neutralizing •OH generated in the presence of SNP-released iron. Cellular internalization of GQD was required for optimal protection, since a removal of extracellular GQD by extensive washing only partly diminished their protective effect. Moreover, GQD cooperated with SNP to induce autophagy, as confirmed by the inhibition of autophagylimiting Akt/PRAS40/mTOR signaling and increase in autophagy gene transcription, protein levels of proautophagic beclin-1 and LC3-II, formation of autophagic vesicles, and degradation of autophagic target p62. The antioxidant activity of GQD was not involved in autophagy induction, as antioxidants N-acetylcysteine and dimethyl sulfoxide failed to stimulate autophagy in SNP-exposed cells. Pharmacological inhibitors of early (wortmannin, 3-methyladenine) or late stages of autophagy (NH4Cl) efficiently reduced the protective effect of GQD. Therefore, the ability of GQD to prevent the in vitro neurotoxicity of SNP depends on both •OH/NO scavenging and induction of cytoprotective autophagy.
T2  - Free Radical Biology and Medicine
T1  - Graphene quantum dot antioxidant and proautophagic actions protect SH-SY5Y neuroblastoma cells from oxidative stress-mediated apoptotic death
VL  - 177
SP  - 167
EP  - 180
DO  - 10.1016/j.freeradbiomed.2021.10.025
ER  - 
@article{
author = "Krunić, Matija and Ristić, Biljana and Bošnjak, Mihajlo and Paunović, Verica and Tovilović-Kovačević, Gordana and Zogović, Nevena and Mirčić, Aleksandar and Marković, Zoran and Todorović-Marković, Biljana and Jovanović, Svetlana P. and Kleut, Duška and Mojović, Miloš and Nakarada, Đura and Marković, Olivera and Vuković, Irena and Harhaji-Trajković, Ljubica and Trajković, Vladimir",
year = "2021",
abstract = "We investigated the ability of graphene quantum dot (GQD) nanoparticles to protect SH-SY5Y human neuroblastoma cells from oxidative/nitrosative stress induced by iron-nitrosyl complex sodium nitroprusside (SNP).GQD reduced SNP cytotoxicity by preventing mitochondrial depolarization, caspase-2 activation, and subsequent apoptotic death. Although GQD diminished the levels of nitric oxide (NO) in SNP-exposed cells, NO scavengers displayed only a slight protective effect, suggesting that NO quenching was not the main protective mechanism of GQD. GQD also reduced SNP-triggered increase in the intracellular levels of hydroxyl radical (•OH), superoxide anion (O2•- ), and lipid peroxidation. Nonselective antioxidants, •OH scavenging, and iron chelators, but not superoxide dismutase, mimicked GQD cytoprotective activity, indicating that GQD protect cells by neutralizing •OH generated in the presence of SNP-released iron. Cellular internalization of GQD was required for optimal protection, since a removal of extracellular GQD by extensive washing only partly diminished their protective effect. Moreover, GQD cooperated with SNP to induce autophagy, as confirmed by the inhibition of autophagylimiting Akt/PRAS40/mTOR signaling and increase in autophagy gene transcription, protein levels of proautophagic beclin-1 and LC3-II, formation of autophagic vesicles, and degradation of autophagic target p62. The antioxidant activity of GQD was not involved in autophagy induction, as antioxidants N-acetylcysteine and dimethyl sulfoxide failed to stimulate autophagy in SNP-exposed cells. Pharmacological inhibitors of early (wortmannin, 3-methyladenine) or late stages of autophagy (NH4Cl) efficiently reduced the protective effect of GQD. Therefore, the ability of GQD to prevent the in vitro neurotoxicity of SNP depends on both •OH/NO scavenging and induction of cytoprotective autophagy.",
journal = "Free Radical Biology and Medicine",
title = "Graphene quantum dot antioxidant and proautophagic actions protect SH-SY5Y neuroblastoma cells from oxidative stress-mediated apoptotic death",
volume = "177",
pages = "167-180",
doi = "10.1016/j.freeradbiomed.2021.10.025"
}
Krunić, M., Ristić, B., Bošnjak, M., Paunović, V., Tovilović-Kovačević, G., Zogović, N., Mirčić, A., Marković, Z., Todorović-Marković, B., Jovanović, S. P., Kleut, D., Mojović, M., Nakarada, Đ., Marković, O., Vuković, I., Harhaji-Trajković, L.,& Trajković, V.. (2021). Graphene quantum dot antioxidant and proautophagic actions protect SH-SY5Y neuroblastoma cells from oxidative stress-mediated apoptotic death. in Free Radical Biology and Medicine, 177, 167-180.
https://doi.org/10.1016/j.freeradbiomed.2021.10.025
Krunić M, Ristić B, Bošnjak M, Paunović V, Tovilović-Kovačević G, Zogović N, Mirčić A, Marković Z, Todorović-Marković B, Jovanović SP, Kleut D, Mojović M, Nakarada Đ, Marković O, Vuković I, Harhaji-Trajković L, Trajković V. Graphene quantum dot antioxidant and proautophagic actions protect SH-SY5Y neuroblastoma cells from oxidative stress-mediated apoptotic death. in Free Radical Biology and Medicine. 2021;177:167-180.
doi:10.1016/j.freeradbiomed.2021.10.025 .
Krunić, Matija, Ristić, Biljana, Bošnjak, Mihajlo, Paunović, Verica, Tovilović-Kovačević, Gordana, Zogović, Nevena, Mirčić, Aleksandar, Marković, Zoran, Todorović-Marković, Biljana, Jovanović, Svetlana P., Kleut, Duška, Mojović, Miloš, Nakarada, Đura, Marković, Olivera, Vuković, Irena, Harhaji-Trajković, Ljubica, Trajković, Vladimir, "Graphene quantum dot antioxidant and proautophagic actions protect SH-SY5Y neuroblastoma cells from oxidative stress-mediated apoptotic death" in Free Radical Biology and Medicine, 177 (2021):167-180,
https://doi.org/10.1016/j.freeradbiomed.2021.10.025 . .

Facile synthesis of L-cysteine functionalized graphene quantum dots as a bioimaging and photosensitive agent

Milenković, Mila; Mišović, Aleksandra; Jovanović, Dragana J.; Popović-Bijelić, Ana D.; Ciasca, Gabriele; Romanò, Sabrina; Bonasera, Aurelio; Mojsin, Marija; Pejić, Jelena; Stevanović, Milena; Jovanović, Svetlana P.

(2021)

TY  - JOUR
AU  - Milenković, Mila
AU  - Mišović, Aleksandra
AU  - Jovanović, Dragana J.
AU  - Popović-Bijelić, Ana D.
AU  - Ciasca, Gabriele
AU  - Romanò, Sabrina
AU  - Bonasera, Aurelio
AU  - Mojsin, Marija
AU  - Pejić, Jelena
AU  - Stevanović, Milena
AU  - Jovanović, Svetlana P.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9873
AB  - Nowadays, a larger number of aggressive and corrosive chemical reagents as well as toxic solvents are used to achieve structural modification and cleaning of the final products. These lead to the production of residual, waste chemicals, which are often reactive, cancerogenic, and toxic to the environment. This study shows a new approach to the modification of graphene quantum dots (GQDs) using gamma irradiation where the usage of reagents was avoided. We achieved the incorporation of S and N atoms in the GQD structure by selecting an aqueous solution of L-cysteine as an irradiation medium. GQDs were exposed to gamma-irradiation at doses of 25, 50 and 200 kGy. After irradiation, the optical, structural, and morphological properties, as well as the possibility of their use as an agent in bioimaging and photodynamic therapy, were studied. We measured an enhanced quantum yield of photoluminescence with the highest dose of 25 kGy (21.60%). Both S- and N-functional groups were detected in all gamma-irradiated GQDs: amino, amide, thiol, and thione. Spin trap electron paramagnetic resonance showed that GQDs irradiated with 25 kGy can generate singlet oxygen upon illumination. Bioimaging on HeLa cells showed the best visibility for cells treated with GQDs irradiated with 25 kGy, while cytotoxicity was not detected after treatment of HeLa cells with gamma-irradiated GQDs.
T2  - Nanomaterials
T1  - Facile synthesis of L-cysteine functionalized graphene quantum dots as a bioimaging and photosensitive agent
VL  - 11
IS  - 8
SP  - 1879
DO  - 10.3390/nano11081879
ER  - 
@article{
author = "Milenković, Mila and Mišović, Aleksandra and Jovanović, Dragana J. and Popović-Bijelić, Ana D. and Ciasca, Gabriele and Romanò, Sabrina and Bonasera, Aurelio and Mojsin, Marija and Pejić, Jelena and Stevanović, Milena and Jovanović, Svetlana P.",
year = "2021",
abstract = "Nowadays, a larger number of aggressive and corrosive chemical reagents as well as toxic solvents are used to achieve structural modification and cleaning of the final products. These lead to the production of residual, waste chemicals, which are often reactive, cancerogenic, and toxic to the environment. This study shows a new approach to the modification of graphene quantum dots (GQDs) using gamma irradiation where the usage of reagents was avoided. We achieved the incorporation of S and N atoms in the GQD structure by selecting an aqueous solution of L-cysteine as an irradiation medium. GQDs were exposed to gamma-irradiation at doses of 25, 50 and 200 kGy. After irradiation, the optical, structural, and morphological properties, as well as the possibility of their use as an agent in bioimaging and photodynamic therapy, were studied. We measured an enhanced quantum yield of photoluminescence with the highest dose of 25 kGy (21.60%). Both S- and N-functional groups were detected in all gamma-irradiated GQDs: amino, amide, thiol, and thione. Spin trap electron paramagnetic resonance showed that GQDs irradiated with 25 kGy can generate singlet oxygen upon illumination. Bioimaging on HeLa cells showed the best visibility for cells treated with GQDs irradiated with 25 kGy, while cytotoxicity was not detected after treatment of HeLa cells with gamma-irradiated GQDs.",
journal = "Nanomaterials",
title = "Facile synthesis of L-cysteine functionalized graphene quantum dots as a bioimaging and photosensitive agent",
volume = "11",
number = "8",
pages = "1879",
doi = "10.3390/nano11081879"
}
Milenković, M., Mišović, A., Jovanović, D. J., Popović-Bijelić, A. D., Ciasca, G., Romanò, S., Bonasera, A., Mojsin, M., Pejić, J., Stevanović, M.,& Jovanović, S. P.. (2021). Facile synthesis of L-cysteine functionalized graphene quantum dots as a bioimaging and photosensitive agent. in Nanomaterials, 11(8), 1879.
https://doi.org/10.3390/nano11081879
Milenković M, Mišović A, Jovanović DJ, Popović-Bijelić AD, Ciasca G, Romanò S, Bonasera A, Mojsin M, Pejić J, Stevanović M, Jovanović SP. Facile synthesis of L-cysteine functionalized graphene quantum dots as a bioimaging and photosensitive agent. in Nanomaterials. 2021;11(8):1879.
doi:10.3390/nano11081879 .
Milenković, Mila, Mišović, Aleksandra, Jovanović, Dragana J., Popović-Bijelić, Ana D., Ciasca, Gabriele, Romanò, Sabrina, Bonasera, Aurelio, Mojsin, Marija, Pejić, Jelena, Stevanović, Milena, Jovanović, Svetlana P., "Facile synthesis of L-cysteine functionalized graphene quantum dots as a bioimaging and photosensitive agent" in Nanomaterials, 11, no. 8 (2021):1879,
https://doi.org/10.3390/nano11081879 . .
1
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A comprehensive review on selected graphene synthesis methods: from electrochemical exfoliation through rapid thermal annealing towards biomass pyrolysis

Prekodravac, Jovana ; Kepić, Dejan P.; Colmenares, Juan Carlos; Giannakoudakis, Dimitrios A.; Jovanović, Svetlana P.

(2021)

TY  - JOUR
AU  - Prekodravac, Jovana 
AU  - Kepić, Dejan P.
AU  - Colmenares, Juan Carlos
AU  - Giannakoudakis, Dimitrios A.
AU  - Jovanović, Svetlana P.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9837
AB  - The progressive development of technology and industry in the new millennium emergently requires finding a balance between economic progress and new smart materials. Graphene as a carbon allotrope since the discovery has attracted enormous attention due to several extraordinary properties that originate from its physical and chemical assets. However, the most important obstacle in graphene assembly still is the production of high-quality graphene on a large scale using cost-effective methods. The presented review article aims to give information on a turning point in graphene synthesis, with reference to a detailed analysis of electrochemical exfoliation, rapid thermal annealing and biomass pyrolysis. Selected methods for graphene and graphene-based nanomaterials production were not covered in the literature to their maximum potential, from our point of view. Through an overview of the selected synthesis methods, we explored their prospects and limitations regarding precursor type and reaction conditions. Furthermore, through several important characterization techniques for graphene, we reveal the details of the properties of graphene and graphene-based nanomaterials obtained through selected methods. Finally, a particular potential application depending on nanomaterial properties obtained through selected methods was pointed out.
T2  - Journal of Materials Chemistry C
T1  - A comprehensive review on selected graphene synthesis methods: from electrochemical exfoliation through rapid thermal annealing towards biomass pyrolysis
VL  - 9
IS  - 21
SP  - 6722
EP  - 6748
DO  - 10.1039/D1TC01316E
ER  - 
@article{
author = "Prekodravac, Jovana  and Kepić, Dejan P. and Colmenares, Juan Carlos and Giannakoudakis, Dimitrios A. and Jovanović, Svetlana P.",
year = "2021",
abstract = "The progressive development of technology and industry in the new millennium emergently requires finding a balance between economic progress and new smart materials. Graphene as a carbon allotrope since the discovery has attracted enormous attention due to several extraordinary properties that originate from its physical and chemical assets. However, the most important obstacle in graphene assembly still is the production of high-quality graphene on a large scale using cost-effective methods. The presented review article aims to give information on a turning point in graphene synthesis, with reference to a detailed analysis of electrochemical exfoliation, rapid thermal annealing and biomass pyrolysis. Selected methods for graphene and graphene-based nanomaterials production were not covered in the literature to their maximum potential, from our point of view. Through an overview of the selected synthesis methods, we explored their prospects and limitations regarding precursor type and reaction conditions. Furthermore, through several important characterization techniques for graphene, we reveal the details of the properties of graphene and graphene-based nanomaterials obtained through selected methods. Finally, a particular potential application depending on nanomaterial properties obtained through selected methods was pointed out.",
journal = "Journal of Materials Chemistry C",
title = "A comprehensive review on selected graphene synthesis methods: from electrochemical exfoliation through rapid thermal annealing towards biomass pyrolysis",
volume = "9",
number = "21",
pages = "6722-6748",
doi = "10.1039/D1TC01316E"
}
Prekodravac, J., Kepić, D. P., Colmenares, J. C., Giannakoudakis, D. A.,& Jovanović, S. P.. (2021). A comprehensive review on selected graphene synthesis methods: from electrochemical exfoliation through rapid thermal annealing towards biomass pyrolysis. in Journal of Materials Chemistry C, 9(21), 6722-6748.
https://doi.org/10.1039/D1TC01316E
Prekodravac J, Kepić DP, Colmenares JC, Giannakoudakis DA, Jovanović SP. A comprehensive review on selected graphene synthesis methods: from electrochemical exfoliation through rapid thermal annealing towards biomass pyrolysis. in Journal of Materials Chemistry C. 2021;9(21):6722-6748.
doi:10.1039/D1TC01316E .
Prekodravac, Jovana , Kepić, Dejan P., Colmenares, Juan Carlos, Giannakoudakis, Dimitrios A., Jovanović, Svetlana P., "A comprehensive review on selected graphene synthesis methods: from electrochemical exfoliation through rapid thermal annealing towards biomass pyrolysis" in Journal of Materials Chemistry C, 9, no. 21 (2021):6722-6748,
https://doi.org/10.1039/D1TC01316E . .
2
6
2
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Recent advances in the label-free characterization of exosomes for cancer liquid biopsy: From scattering and spectroscopy to nanoindentation and nanodevices

Di Santo, Riccardo; Romanò, Sabrina; Mazzini, Alberto; Jovanović, Svetlana P.; Nocca, Giuseppina; Campi, Gaetano; Papi, Massimiliano; De Spirito, Marco; Di Giacinto, Flavio; Ciasca, Gabriele

(2021)

TY  - JOUR
AU  - Di Santo, Riccardo
AU  - Romanò, Sabrina
AU  - Mazzini, Alberto
AU  - Jovanović, Svetlana P.
AU  - Nocca, Giuseppina
AU  - Campi, Gaetano
AU  - Papi, Massimiliano
AU  - De Spirito, Marco
AU  - Di Giacinto, Flavio
AU  - Ciasca, Gabriele
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9832
AB  - Exosomes (EXOs) are nano-sized vesicles secreted by most cell types. They are abundant in bio-fluids and harbor specific molecular constituents from their parental cells. Due to these characteristics, EXOs have a great potential in cancer diagnostics for liquid biopsy and personalized medicine. Despite this unique potential, EXOs are not yet widely applied in clinical settings, with two main factors hindering their translational process in diagnostics. Firstly, conventional extraction methods are time-consuming, require large sample volumes and expensive equipment, and often do not provide high-purity samples. Secondly, characterization methods have some limitations, because they are often qualitative, need extensive labeling or complex sampling procedures that can induce artifacts. In this context, novel label-free approaches are rapidly emerging, and are holding potential to revolutionize EXO diagnostics. These methods include the use of nanodevices for EXO purification, and vibrational spectroscopies, scattering, and nanoindentation for characterization. In this progress report, we summarize recent key advances in label-free techniques for EXO purification and characterization. We point out that these methods contribute to reducing costs and processing times, provide complementary information compared to the conventional characterization techniques, and enhance flexibility, thus favoring the discovery of novel and unexplored EXO-based biomarkers. In this process, the impact of nanotechnology is systematically highlighted, showing how the effectiveness of these techniques can be enhanced using nanomaterials, such as plasmonic nanoparticles and nanostructured surfaces, which enable the exploitation of advanced physical phenomena occurring at the nanoscale level.
T2  - Nanomaterials
T1  - Recent advances in the label-free characterization of exosomes for cancer liquid biopsy: From scattering and spectroscopy to nanoindentation and nanodevices
VL  - 11
IS  - 6
SP  - 1476
DO  - 10.3390/nano11061476
ER  - 
@article{
author = "Di Santo, Riccardo and Romanò, Sabrina and Mazzini, Alberto and Jovanović, Svetlana P. and Nocca, Giuseppina and Campi, Gaetano and Papi, Massimiliano and De Spirito, Marco and Di Giacinto, Flavio and Ciasca, Gabriele",
year = "2021",
abstract = "Exosomes (EXOs) are nano-sized vesicles secreted by most cell types. They are abundant in bio-fluids and harbor specific molecular constituents from their parental cells. Due to these characteristics, EXOs have a great potential in cancer diagnostics for liquid biopsy and personalized medicine. Despite this unique potential, EXOs are not yet widely applied in clinical settings, with two main factors hindering their translational process in diagnostics. Firstly, conventional extraction methods are time-consuming, require large sample volumes and expensive equipment, and often do not provide high-purity samples. Secondly, characterization methods have some limitations, because they are often qualitative, need extensive labeling or complex sampling procedures that can induce artifacts. In this context, novel label-free approaches are rapidly emerging, and are holding potential to revolutionize EXO diagnostics. These methods include the use of nanodevices for EXO purification, and vibrational spectroscopies, scattering, and nanoindentation for characterization. In this progress report, we summarize recent key advances in label-free techniques for EXO purification and characterization. We point out that these methods contribute to reducing costs and processing times, provide complementary information compared to the conventional characterization techniques, and enhance flexibility, thus favoring the discovery of novel and unexplored EXO-based biomarkers. In this process, the impact of nanotechnology is systematically highlighted, showing how the effectiveness of these techniques can be enhanced using nanomaterials, such as plasmonic nanoparticles and nanostructured surfaces, which enable the exploitation of advanced physical phenomena occurring at the nanoscale level.",
journal = "Nanomaterials",
title = "Recent advances in the label-free characterization of exosomes for cancer liquid biopsy: From scattering and spectroscopy to nanoindentation and nanodevices",
volume = "11",
number = "6",
pages = "1476",
doi = "10.3390/nano11061476"
}
Di Santo, R., Romanò, S., Mazzini, A., Jovanović, S. P., Nocca, G., Campi, G., Papi, M., De Spirito, M., Di Giacinto, F.,& Ciasca, G.. (2021). Recent advances in the label-free characterization of exosomes for cancer liquid biopsy: From scattering and spectroscopy to nanoindentation and nanodevices. in Nanomaterials, 11(6), 1476.
https://doi.org/10.3390/nano11061476
Di Santo R, Romanò S, Mazzini A, Jovanović SP, Nocca G, Campi G, Papi M, De Spirito M, Di Giacinto F, Ciasca G. Recent advances in the label-free characterization of exosomes for cancer liquid biopsy: From scattering and spectroscopy to nanoindentation and nanodevices. in Nanomaterials. 2021;11(6):1476.
doi:10.3390/nano11061476 .
Di Santo, Riccardo, Romanò, Sabrina, Mazzini, Alberto, Jovanović, Svetlana P., Nocca, Giuseppina, Campi, Gaetano, Papi, Massimiliano, De Spirito, Marco, Di Giacinto, Flavio, Ciasca, Gabriele, "Recent advances in the label-free characterization of exosomes for cancer liquid biopsy: From scattering and spectroscopy to nanoindentation and nanodevices" in Nanomaterials, 11, no. 6 (2021):1476,
https://doi.org/10.3390/nano11061476 . .
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Enhanced visible light-triggered antibacterial activity of carbon quantum dots/polyurethane nanocomposites by gamma rays induced pre-treatment

Budimir, Milica; Marković, Zoran M.; Vajdak, Jan; Jovanović, Svetlana P.; Kubat, Pavel; Humpoliček, Petr; Mičušik, Matej; Danko, Martin; Barras, Alexandre; Milivojević, Dušan; Špitalsky, Zdenko; Boukherroub, Rabah; Todorović-Marković, Biljana

(2021)

TY  - JOUR
AU  - Budimir, Milica
AU  - Marković, Zoran M.
AU  - Vajdak, Jan
AU  - Jovanović, Svetlana P.
AU  - Kubat, Pavel
AU  - Humpoliček, Petr
AU  - Mičušik, Matej
AU  - Danko, Martin
AU  - Barras, Alexandre
AU  - Milivojević, Dušan
AU  - Špitalsky, Zdenko
AU  - Boukherroub, Rabah
AU  - Todorović-Marković, Biljana
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9746
AB  - Persistent microbial contamination of medical implant surfaces is becoming a serious threat to public health. This is principally due to antibiotic-resistant bacterial strains and the formation of bacterial biofilms. The development of novel antibacterial materials that will effectively fight both Gram-positive and Gram-negative bacteria and prevent biofilm formation represents a big challenge for researchers in the last few decades. In the present work, we report an antibacterial hydrophobic carbon quantum dots/polyurethane nanocomposite (hCQD-PU), with enhanced antibacterial properties induced by pre-treatment with gamma-irradiation. Hydrophobic quantum dots (hCQDs), which are capable of generating reactive oxygen species (ROS) upon irradiation with low-power blue light (470 nm), have been integrated into the polyurethane (PU) polymer matrix to form a photoactive nanocomposite. To modify its physical and chemical properties and improve its antibacterial efficacy, various doses of gamma irradiation (1, 10, and 200 kGy) in the air environment were applied to the formed nanocomposite. Gamma-irradiation pre-treatment significantly influenced the rise in ROS production, therefore, the prooxidative activity under the blue-light illumination of hCQD-PU was also significantly improved. The best antibacterial activity was demonstrated by the hCQD-PU nanocomposite irradiated with a dose of 200 kGy, with the complete eradication of Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli) bacteria after 15 min of exposure to the blue lamp. © 2021 Elsevier Ltd
T2  - Radiation Physics and Chemistry
T1  - Enhanced visible light-triggered antibacterial activity of carbon quantum dots/polyurethane nanocomposites by gamma rays induced pre-treatment
VL  - 185
SP  - 109499
DO  - 10.1016/j.radphyschem.2021.109499
ER  - 
@article{
author = "Budimir, Milica and Marković, Zoran M. and Vajdak, Jan and Jovanović, Svetlana P. and Kubat, Pavel and Humpoliček, Petr and Mičušik, Matej and Danko, Martin and Barras, Alexandre and Milivojević, Dušan and Špitalsky, Zdenko and Boukherroub, Rabah and Todorović-Marković, Biljana",
year = "2021",
abstract = "Persistent microbial contamination of medical implant surfaces is becoming a serious threat to public health. This is principally due to antibiotic-resistant bacterial strains and the formation of bacterial biofilms. The development of novel antibacterial materials that will effectively fight both Gram-positive and Gram-negative bacteria and prevent biofilm formation represents a big challenge for researchers in the last few decades. In the present work, we report an antibacterial hydrophobic carbon quantum dots/polyurethane nanocomposite (hCQD-PU), with enhanced antibacterial properties induced by pre-treatment with gamma-irradiation. Hydrophobic quantum dots (hCQDs), which are capable of generating reactive oxygen species (ROS) upon irradiation with low-power blue light (470 nm), have been integrated into the polyurethane (PU) polymer matrix to form a photoactive nanocomposite. To modify its physical and chemical properties and improve its antibacterial efficacy, various doses of gamma irradiation (1, 10, and 200 kGy) in the air environment were applied to the formed nanocomposite. Gamma-irradiation pre-treatment significantly influenced the rise in ROS production, therefore, the prooxidative activity under the blue-light illumination of hCQD-PU was also significantly improved. The best antibacterial activity was demonstrated by the hCQD-PU nanocomposite irradiated with a dose of 200 kGy, with the complete eradication of Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli) bacteria after 15 min of exposure to the blue lamp. © 2021 Elsevier Ltd",
journal = "Radiation Physics and Chemistry",
title = "Enhanced visible light-triggered antibacterial activity of carbon quantum dots/polyurethane nanocomposites by gamma rays induced pre-treatment",
volume = "185",
pages = "109499",
doi = "10.1016/j.radphyschem.2021.109499"
}
Budimir, M., Marković, Z. M., Vajdak, J., Jovanović, S. P., Kubat, P., Humpoliček, P., Mičušik, M., Danko, M., Barras, A., Milivojević, D., Špitalsky, Z., Boukherroub, R.,& Todorović-Marković, B.. (2021). Enhanced visible light-triggered antibacterial activity of carbon quantum dots/polyurethane nanocomposites by gamma rays induced pre-treatment. in Radiation Physics and Chemistry, 185, 109499.
https://doi.org/10.1016/j.radphyschem.2021.109499
Budimir M, Marković ZM, Vajdak J, Jovanović SP, Kubat P, Humpoliček P, Mičušik M, Danko M, Barras A, Milivojević D, Špitalsky Z, Boukherroub R, Todorović-Marković B. Enhanced visible light-triggered antibacterial activity of carbon quantum dots/polyurethane nanocomposites by gamma rays induced pre-treatment. in Radiation Physics and Chemistry. 2021;185:109499.
doi:10.1016/j.radphyschem.2021.109499 .
Budimir, Milica, Marković, Zoran M., Vajdak, Jan, Jovanović, Svetlana P., Kubat, Pavel, Humpoliček, Petr, Mičušik, Matej, Danko, Martin, Barras, Alexandre, Milivojević, Dušan, Špitalsky, Zdenko, Boukherroub, Rabah, Todorović-Marković, Biljana, "Enhanced visible light-triggered antibacterial activity of carbon quantum dots/polyurethane nanocomposites by gamma rays induced pre-treatment" in Radiation Physics and Chemistry, 185 (2021):109499,
https://doi.org/10.1016/j.radphyschem.2021.109499 . .
1
1

Radonski ravnotežni faktor u izabranim rezidencijalnim i radnim objektima u Srbiji i Crnoj Gori

Čeliković, Igor T.; Zekić, Ranko; Svrkota, Nikola; Vukanac, Ivana; Živanović, Miloš Z.; Krneta-Nikolić, Jelena D.; Vukotić, Perko; Pantelić, Gordana K.

(Institut za nuklearne nauke "Vinča", 2021)

TY  - CONF
AU  - Čeliković, Igor T.
AU  - Zekić, Ranko
AU  - Svrkota, Nikola
AU  - Vukanac, Ivana
AU  - Živanović, Miloš Z.
AU  - Krneta-Nikolić, Jelena D.
AU  - Vukotić, Perko
AU  - Pantelić, Gordana K.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10002
AB  - U radu su prikazani rezultati merenja radonskog ravnotežnog faktora aktivnom metodom na 5 lokacija u Crnoj Gori i Srbiji. Dobijeni rezultati su u rasponu od 0.36 do 0.7, što je u proseku veće od preporučene vrednosti od 0.4. Na istim lokacijama su izvršena interkomparativna merenja koncentracije radona (uređajima Alpha Guard Pro, RAD7 i RTM1688-2), ravnotežne ekvivalentne koncentracije radona (uređajima RNWL i RPM2200) i radonskog ravnotežnog faktora. Slaganje rezultata je testirano Z-testom koji ukazuje da ne postoji statistički značajno odstupanje između rezultata dobijenih različitim mernim uređajima, odnosno ne postoji nekonzistentnost između različitih metodologija merenja kao ni potrebe za harmonizacijom različitih procedura merenja.
AB  - In this contribution, the results of radon equilibrium factor measurement in selected dwelling and workplaces in Montenegro and Serbia are presented. Radon equilibrium factor was derived from measurements of indoor radon concentration and equilibrium equivalent radon concentration. Measurements were performed one day for each of 5 locations by using different active devices. Obtained radon equilibrium factors range from 0.36 to 0.7 which is in average larger than worldwide average of 0.4 Results are not surprising since measuring locations were kept closed during the measuring time, reducing therefore ventilation rate which as a consequence has an increase of equilibrium factor. Individual measuring results of indoor radon concentrations, equilibrium equivalent radon concentrations and radon equilibrium factors obtained with different detectors systems from 2 research teams was tested using Z – test. Obtained Z – score for each measurement vas below critical value, indication that there is no statistical difference between different measuring devices.
PB  - Institut za nuklearne nauke "Vinča"
PB  - Društvo za zaštitu od zračenja Srbije i Crne Gore
C3  - 31. симпозијум ДЗЗСЦГ : зборник радова
T1  - Radonski ravnotežni faktor u izabranim rezidencijalnim i radnim objektima u Srbiji i Crnoj Gori
T1  - Radon Equilibrium Factor in Selected Dwellings and Workplaces in Montenegro and Serbia
SP  - 121
EP  - 127
ER  - 
@conference{
author = "Čeliković, Igor T. and Zekić, Ranko and Svrkota, Nikola and Vukanac, Ivana and Živanović, Miloš Z. and Krneta-Nikolić, Jelena D. and Vukotić, Perko and Pantelić, Gordana K.",
year = "2021",
abstract = "U radu su prikazani rezultati merenja radonskog ravnotežnog faktora aktivnom metodom na 5 lokacija u Crnoj Gori i Srbiji. Dobijeni rezultati su u rasponu od 0.36 do 0.7, što je u proseku veće od preporučene vrednosti od 0.4. Na istim lokacijama su izvršena interkomparativna merenja koncentracije radona (uređajima Alpha Guard Pro, RAD7 i RTM1688-2), ravnotežne ekvivalentne koncentracije radona (uređajima RNWL i RPM2200) i radonskog ravnotežnog faktora. Slaganje rezultata je testirano Z-testom koji ukazuje da ne postoji statistički značajno odstupanje između rezultata dobijenih različitim mernim uređajima, odnosno ne postoji nekonzistentnost između različitih metodologija merenja kao ni potrebe za harmonizacijom različitih procedura merenja., In this contribution, the results of radon equilibrium factor measurement in selected dwelling and workplaces in Montenegro and Serbia are presented. Radon equilibrium factor was derived from measurements of indoor radon concentration and equilibrium equivalent radon concentration. Measurements were performed one day for each of 5 locations by using different active devices. Obtained radon equilibrium factors range from 0.36 to 0.7 which is in average larger than worldwide average of 0.4 Results are not surprising since measuring locations were kept closed during the measuring time, reducing therefore ventilation rate which as a consequence has an increase of equilibrium factor. Individual measuring results of indoor radon concentrations, equilibrium equivalent radon concentrations and radon equilibrium factors obtained with different detectors systems from 2 research teams was tested using Z – test. Obtained Z – score for each measurement vas below critical value, indication that there is no statistical difference between different measuring devices.",
publisher = "Institut za nuklearne nauke "Vinča", Društvo za zaštitu od zračenja Srbije i Crne Gore",
journal = "31. симпозијум ДЗЗСЦГ : зборник радова",
title = "Radonski ravnotežni faktor u izabranim rezidencijalnim i radnim objektima u Srbiji i Crnoj Gori, Radon Equilibrium Factor in Selected Dwellings and Workplaces in Montenegro and Serbia",
pages = "121-127"
}
Čeliković, I. T., Zekić, R., Svrkota, N., Vukanac, I., Živanović, M. Z., Krneta-Nikolić, J. D., Vukotić, P.,& Pantelić, G. K.. (2021). Radonski ravnotežni faktor u izabranim rezidencijalnim i radnim objektima u Srbiji i Crnoj Gori. in 31. симпозијум ДЗЗСЦГ : зборник радова
Institut za nuklearne nauke "Vinča"., 121-127.
Čeliković IT, Zekić R, Svrkota N, Vukanac I, Živanović MZ, Krneta-Nikolić JD, Vukotić P, Pantelić GK. Radonski ravnotežni faktor u izabranim rezidencijalnim i radnim objektima u Srbiji i Crnoj Gori. in 31. симпозијум ДЗЗСЦГ : зборник радова. 2021;:121-127..
Čeliković, Igor T., Zekić, Ranko, Svrkota, Nikola, Vukanac, Ivana, Živanović, Miloš Z., Krneta-Nikolić, Jelena D., Vukotić, Perko, Pantelić, Gordana K., "Radonski ravnotežni faktor u izabranim rezidencijalnim i radnim objektima u Srbiji i Crnoj Gori" in 31. симпозијум ДЗЗСЦГ : зборник радова (2021):121-127.

Application of Copper Mining Waste in Radionuclide and Heavy Metal Immobilization

Dimović, Slavko; Jelić, Ivana; Šljivić-Ivanović, Marija; Štirbanović, Zoran; Gardić, Vojka; Marković, Radmila; Savić, Aleksandar R.; Zakić, Dimitrije

(2021)

TY  - JOUR
AU  - Dimović, Slavko
AU  - Jelić, Ivana
AU  - Šljivić-Ivanović, Marija
AU  - Štirbanović, Zoran
AU  - Gardić, Vojka
AU  - Marković, Radmila
AU  - Savić, Aleksandar R.
AU  - Zakić, Dimitrije
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10031
AB  - Copper slag flotation tailings (CSFT), as the end waste from copper mining, are evaluated for radionuclide and heavy metal immobilization. Characterization of CSFT based on grain size and mineral composition, surface functional groups, pH and electrical conductivity in aqueous media, thermogravimetric analysis (TGA), determination of characteristic temperatures in sample melting process, leachability, and toxicity tests is conducted. The screening sorption of Mn(II), Co(II), Ni(II), Zn(II), Cd(II), and Pb(II) inactive isotopes from single-component solutions is performed. The Cd(II) ions show better sorption potential than other ions, with a sorption capacity of 0.08 mmol g−1 at the highest initial concentration. Sorption decreases in the sequence Cd(II) > Pb(II) > Zn(II) > Mn(II) > Ni(II) > Co(II) at all initial concentrations. Although CSFT shows lower sorption capability than synthetic sorbents based on fayalite and magnetite, its inexpensiveness and substantial accessible amount represent great advantages in wider utilization.
T2  - Clean - Soil, Air, Water
T1  - Application of Copper Mining Waste in Radionuclide and Heavy Metal Immobilization
IS  - 10
SP  - 2000419
DO  - 10.1002/clen.202000419
ER  - 
@article{
author = "Dimović, Slavko and Jelić, Ivana and Šljivić-Ivanović, Marija and Štirbanović, Zoran and Gardić, Vojka and Marković, Radmila and Savić, Aleksandar R. and Zakić, Dimitrije",
year = "2021",
abstract = "Copper slag flotation tailings (CSFT), as the end waste from copper mining, are evaluated for radionuclide and heavy metal immobilization. Characterization of CSFT based on grain size and mineral composition, surface functional groups, pH and electrical conductivity in aqueous media, thermogravimetric analysis (TGA), determination of characteristic temperatures in sample melting process, leachability, and toxicity tests is conducted. The screening sorption of Mn(II), Co(II), Ni(II), Zn(II), Cd(II), and Pb(II) inactive isotopes from single-component solutions is performed. The Cd(II) ions show better sorption potential than other ions, with a sorption capacity of 0.08 mmol g−1 at the highest initial concentration. Sorption decreases in the sequence Cd(II) > Pb(II) > Zn(II) > Mn(II) > Ni(II) > Co(II) at all initial concentrations. Although CSFT shows lower sorption capability than synthetic sorbents based on fayalite and magnetite, its inexpensiveness and substantial accessible amount represent great advantages in wider utilization.",
journal = "Clean - Soil, Air, Water",
title = "Application of Copper Mining Waste in Radionuclide and Heavy Metal Immobilization",
number = "10",
pages = "2000419",
doi = "10.1002/clen.202000419"
}
Dimović, S., Jelić, I., Šljivić-Ivanović, M., Štirbanović, Z., Gardić, V., Marković, R., Savić, A. R.,& Zakić, D.. (2021). Application of Copper Mining Waste in Radionuclide and Heavy Metal Immobilization. in Clean - Soil, Air, Water(10), 2000419.
https://doi.org/10.1002/clen.202000419
Dimović S, Jelić I, Šljivić-Ivanović M, Štirbanović Z, Gardić V, Marković R, Savić AR, Zakić D. Application of Copper Mining Waste in Radionuclide and Heavy Metal Immobilization. in Clean - Soil, Air, Water. 2021;(10):2000419.
doi:10.1002/clen.202000419 .
Dimović, Slavko, Jelić, Ivana, Šljivić-Ivanović, Marija, Štirbanović, Zoran, Gardić, Vojka, Marković, Radmila, Savić, Aleksandar R., Zakić, Dimitrije, "Application of Copper Mining Waste in Radionuclide and Heavy Metal Immobilization" in Clean - Soil, Air, Water, no. 10 (2021):2000419,
https://doi.org/10.1002/clen.202000419 . .

Triple-temperature readout in luminescence thermometry with Cr3+-doped Mg2SiO4 operating from cryogenic to physiologically relevant temperatures

Ristić, Zoran; Đorđević, Vesna R.; Medić, Mina; Kuzman, Sanja; Sekulić, Milica; Antić, Željka; Dramićanin, Miroslav

(2021)

TY  - JOUR
AU  - Ristić, Zoran
AU  - Đorđević, Vesna R.
AU  - Medić, Mina
AU  - Kuzman, Sanja
AU  - Sekulić, Milica
AU  - Antić, Željka
AU  - Dramićanin, Miroslav
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9624
AB  - Cr3+-doped Mg2SiO4 orthorhombic nanoparticles are synthesized by a combustion method. The 3d3 electron configuration of the Cr3+ ion results in the deep-red emission from optical transitions between d-d orbitals. Two overlapping emissions from the Cr3+ spin-forbidden 2Eg→ 4A2g and the spin-allowed 4T2g→ 4A2g electronic transitions are influenced by the strong crystal field in Mg2SiO4 and, thus, are suitable for ratiometric luminescence thermometry. The temperature-induced changes in Cr3+-doped Mg2SiO4 emission are tested for use in luminescence thermometry from cryogenic to physiologically relevant temperatures (10-350 K) by three approaches: (a) temperature-induced changes of emission intensity; (b) temperature-dependent luminescence lifetime; and (c) temperature-induced changes of emission band position. The second approach offers applicable thermometry at cryogenic temperatures, starting from temperatures as low as 50 K, while all three approaches offer applicable thermometry at physiologically relevant temperatures with relative sensitivities of 0.7% K-1 for emission intensity, 0.8% K-1 for lifetime and 0.85% K-1 for band position at 310 K. © 2021 IOP Publishing Ltd.
T2  - Measurement Science and Technology
T1  - Triple-temperature readout in luminescence thermometry with Cr3+-doped Mg2SiO4 operating from cryogenic to physiologically relevant temperatures
VL  - 32
IS  - 5
SP  - 054004
DO  - 10.1088/1361-6501/abdc9a
ER  - 
@article{
author = "Ristić, Zoran and Đorđević, Vesna R. and Medić, Mina and Kuzman, Sanja and Sekulić, Milica and Antić, Željka and Dramićanin, Miroslav",
year = "2021",
abstract = "Cr3+-doped Mg2SiO4 orthorhombic nanoparticles are synthesized by a combustion method. The 3d3 electron configuration of the Cr3+ ion results in the deep-red emission from optical transitions between d-d orbitals. Two overlapping emissions from the Cr3+ spin-forbidden 2Eg→ 4A2g and the spin-allowed 4T2g→ 4A2g electronic transitions are influenced by the strong crystal field in Mg2SiO4 and, thus, are suitable for ratiometric luminescence thermometry. The temperature-induced changes in Cr3+-doped Mg2SiO4 emission are tested for use in luminescence thermometry from cryogenic to physiologically relevant temperatures (10-350 K) by three approaches: (a) temperature-induced changes of emission intensity; (b) temperature-dependent luminescence lifetime; and (c) temperature-induced changes of emission band position. The second approach offers applicable thermometry at cryogenic temperatures, starting from temperatures as low as 50 K, while all three approaches offer applicable thermometry at physiologically relevant temperatures with relative sensitivities of 0.7% K-1 for emission intensity, 0.8% K-1 for lifetime and 0.85% K-1 for band position at 310 K. © 2021 IOP Publishing Ltd.",
journal = "Measurement Science and Technology",
title = "Triple-temperature readout in luminescence thermometry with Cr3+-doped Mg2SiO4 operating from cryogenic to physiologically relevant temperatures",
volume = "32",
number = "5",
pages = "054004",
doi = "10.1088/1361-6501/abdc9a"
}
Ristić, Z., Đorđević, V. R., Medić, M., Kuzman, S., Sekulić, M., Antić, Ž.,& Dramićanin, M.. (2021). Triple-temperature readout in luminescence thermometry with Cr3+-doped Mg2SiO4 operating from cryogenic to physiologically relevant temperatures. in Measurement Science and Technology, 32(5), 054004.
https://doi.org/10.1088/1361-6501/abdc9a
Ristić Z, Đorđević VR, Medić M, Kuzman S, Sekulić M, Antić Ž, Dramićanin M. Triple-temperature readout in luminescence thermometry with Cr3+-doped Mg2SiO4 operating from cryogenic to physiologically relevant temperatures. in Measurement Science and Technology. 2021;32(5):054004.
doi:10.1088/1361-6501/abdc9a .
Ristić, Zoran, Đorđević, Vesna R., Medić, Mina, Kuzman, Sanja, Sekulić, Milica, Antić, Željka, Dramićanin, Miroslav, "Triple-temperature readout in luminescence thermometry with Cr3+-doped Mg2SiO4 operating from cryogenic to physiologically relevant temperatures" in Measurement Science and Technology, 32, no. 5 (2021):054004,
https://doi.org/10.1088/1361-6501/abdc9a . .
9
8

Controllable ablative machining of Al/Ti and Ti/Al nano-layers on a Si substrate by single-pulse femtosecond laser irradiation

Gaković, Biljana M.; Kudryashov, S. I.; Danilov, P. A.; Milovanović, D.; Panjan, P.; Bezhanov, S. G.; Uryupin, S. A.; Ionin, A. A.

(2021)

TY  - JOUR
AU  - Gaković, Biljana M.
AU  - Kudryashov, S. I.
AU  - Danilov, P. A.
AU  - Milovanović, D.
AU  - Panjan, P.
AU  - Bezhanov, S. G.
AU  - Uryupin, S. A.
AU  - Ionin, A. A.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10012
AB  - Results concerning the controllable ablation of nano-layered thin films (NLTF) by femtosecond laser pulses are presented. Investigated samples were titanium-aluminum bilayers, deposited on a silicon substrate, with the top titanium or aluminum layer of variable thickness on the surface. Irradiation was done in ambient air with single femtosecond laser pulses under standard laboratory conditions. The samples were analyzed by complementary methods of optical and scanning electron microscopy and optical profilometry, exhibiting laser-fluence-dependent ablative removal either of the top layer or the entire bilayer or even partial ablation of the underlying silicon substrate. The removal (spallation) threshold fluences for the topmost layer are scalable versus its thickness almost irrespectively of its material, being rather selective for the Ti-coated samples and much less selective for the Al-coated samples. The removal of the entire bilayers was found to be strongly influenced by electronic properties of the underlying metallic layer, dictating the NLTF-Si adhesion, heat conduction, and capacity in the NLTFs toward the NLTF-Si interface and beyond, as well as by their thermophysical characteristics, e.g., almost twice higher melting temperature and enthalpy for Ti. As a result, precise fs-laser machining of the entire NLTFs is pronounced and selective for the samples with the fusible Al at the low-adhesion Al-Si interfaces, compared with the incomplete NLTF removal from the high-adhesion and refractory Ti-Si interfaces.
T2  - Applied Optics
T1  - Controllable ablative machining of Al/Ti and Ti/Al nano-layers on a Si substrate by single-pulse femtosecond laser irradiation
VL  - 60
IS  - 31
SP  - H12
EP  - H19
DO  - 10.1364/AO.432691
ER  - 
@article{
author = "Gaković, Biljana M. and Kudryashov, S. I. and Danilov, P. A. and Milovanović, D. and Panjan, P. and Bezhanov, S. G. and Uryupin, S. A. and Ionin, A. A.",
year = "2021",
abstract = "Results concerning the controllable ablation of nano-layered thin films (NLTF) by femtosecond laser pulses are presented. Investigated samples were titanium-aluminum bilayers, deposited on a silicon substrate, with the top titanium or aluminum layer of variable thickness on the surface. Irradiation was done in ambient air with single femtosecond laser pulses under standard laboratory conditions. The samples were analyzed by complementary methods of optical and scanning electron microscopy and optical profilometry, exhibiting laser-fluence-dependent ablative removal either of the top layer or the entire bilayer or even partial ablation of the underlying silicon substrate. The removal (spallation) threshold fluences for the topmost layer are scalable versus its thickness almost irrespectively of its material, being rather selective for the Ti-coated samples and much less selective for the Al-coated samples. The removal of the entire bilayers was found to be strongly influenced by electronic properties of the underlying metallic layer, dictating the NLTF-Si adhesion, heat conduction, and capacity in the NLTFs toward the NLTF-Si interface and beyond, as well as by their thermophysical characteristics, e.g., almost twice higher melting temperature and enthalpy for Ti. As a result, precise fs-laser machining of the entire NLTFs is pronounced and selective for the samples with the fusible Al at the low-adhesion Al-Si interfaces, compared with the incomplete NLTF removal from the high-adhesion and refractory Ti-Si interfaces.",
journal = "Applied Optics",
title = "Controllable ablative machining of Al/Ti and Ti/Al nano-layers on a Si substrate by single-pulse femtosecond laser irradiation",
volume = "60",
number = "31",
pages = "H12-H19",
doi = "10.1364/AO.432691"
}
Gaković, B. M., Kudryashov, S. I., Danilov, P. A., Milovanović, D., Panjan, P., Bezhanov, S. G., Uryupin, S. A.,& Ionin, A. A.. (2021). Controllable ablative machining of Al/Ti and Ti/Al nano-layers on a Si substrate by single-pulse femtosecond laser irradiation. in Applied Optics, 60(31), H12-H19.
https://doi.org/10.1364/AO.432691
Gaković BM, Kudryashov SI, Danilov PA, Milovanović D, Panjan P, Bezhanov SG, Uryupin SA, Ionin AA. Controllable ablative machining of Al/Ti and Ti/Al nano-layers on a Si substrate by single-pulse femtosecond laser irradiation. in Applied Optics. 2021;60(31):H12-H19.
doi:10.1364/AO.432691 .
Gaković, Biljana M., Kudryashov, S. I., Danilov, P. A., Milovanović, D., Panjan, P., Bezhanov, S. G., Uryupin, S. A., Ionin, A. A., "Controllable ablative machining of Al/Ti and Ti/Al nano-layers on a Si substrate by single-pulse femtosecond laser irradiation" in Applied Optics, 60, no. 31 (2021):H12-H19,
https://doi.org/10.1364/AO.432691 . .

The morphological and compositional changes of bimetallic Ti/Al thin film induced by ultra-short laser pulses

Gaković, Biljana M.; Danilov, Pavel A.; Kudryashov, Sergey I.; Milovanović, Dubravka S.; Radulović, Aleksandra ; Panjan, Peter; Ionin, Andrey A.

(2021)

TY  - JOUR
AU  - Gaković, Biljana M.
AU  - Danilov, Pavel A.
AU  - Kudryashov, Sergey I.
AU  - Milovanović, Dubravka S.
AU  - Radulović, Aleksandra 
AU  - Panjan, Peter
AU  - Ionin, Andrey A.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10038
AB  - Results regarding morphological and compositional changes of bimetallic thin film (BMTF), composed of aluminium (Al) and titanium (Ti) nano-layers, by single fs laser pulses, are presented. Laser irradiation was conducted in the air with focused, linearly polarized laser pulses, the duration being 300 fs, wavelength 515 nm, and pulse energy up to 1.2μJ. Effects of the variations of the pulse energy on the changes were studied. In the experiment, single pulse energy values from 0.03 to 0.08 μ J caused ablation–photomechanical spallation of the upper part of BMTF layer from the Si substrate, without ablation of the whole film. Irradiation at higher pulse energies gradually removed the whole BMTF and even a part of the Si substrate. We explained the influence of different electron–phonon dynamics, in the case of multilayered thin films composed of Al and Ti, on BMTF ablation. Damage/ablation threshold, which is minimal pulse energy/fluence sufficient for starting ablation, was calculated. Graphic abstract: [Figure not available: see fulltext.] © 2021, The Author(s), under exclusive licence to EDP Sciences, SIF and Springer-Verlag GmbH Germany, part of Springer Nature.
T2  - European Physical Journal D
T1  - The morphological and compositional changes of bimetallic Ti/Al thin film induced by ultra-short laser pulses
VL  - 75
IS  - 11
DO  - 10.1140/epjd/s10053-021-00292-4
ER  - 
@article{
author = "Gaković, Biljana M. and Danilov, Pavel A. and Kudryashov, Sergey I. and Milovanović, Dubravka S. and Radulović, Aleksandra  and Panjan, Peter and Ionin, Andrey A.",
year = "2021",
abstract = "Results regarding morphological and compositional changes of bimetallic thin film (BMTF), composed of aluminium (Al) and titanium (Ti) nano-layers, by single fs laser pulses, are presented. Laser irradiation was conducted in the air with focused, linearly polarized laser pulses, the duration being 300 fs, wavelength 515 nm, and pulse energy up to 1.2μJ. Effects of the variations of the pulse energy on the changes were studied. In the experiment, single pulse energy values from 0.03 to 0.08 μ J caused ablation–photomechanical spallation of the upper part of BMTF layer from the Si substrate, without ablation of the whole film. Irradiation at higher pulse energies gradually removed the whole BMTF and even a part of the Si substrate. We explained the influence of different electron–phonon dynamics, in the case of multilayered thin films composed of Al and Ti, on BMTF ablation. Damage/ablation threshold, which is minimal pulse energy/fluence sufficient for starting ablation, was calculated. Graphic abstract: [Figure not available: see fulltext.] © 2021, The Author(s), under exclusive licence to EDP Sciences, SIF and Springer-Verlag GmbH Germany, part of Springer Nature.",
journal = "European Physical Journal D",
title = "The morphological and compositional changes of bimetallic Ti/Al thin film induced by ultra-short laser pulses",
volume = "75",
number = "11",
doi = "10.1140/epjd/s10053-021-00292-4"
}
Gaković, B. M., Danilov, P. A., Kudryashov, S. I., Milovanović, D. S., Radulović, A., Panjan, P.,& Ionin, A. A.. (2021). The morphological and compositional changes of bimetallic Ti/Al thin film induced by ultra-short laser pulses. in European Physical Journal D, 75(11).
https://doi.org/10.1140/epjd/s10053-021-00292-4
Gaković BM, Danilov PA, Kudryashov SI, Milovanović DS, Radulović A, Panjan P, Ionin AA. The morphological and compositional changes of bimetallic Ti/Al thin film induced by ultra-short laser pulses. in European Physical Journal D. 2021;75(11).
doi:10.1140/epjd/s10053-021-00292-4 .
Gaković, Biljana M., Danilov, Pavel A., Kudryashov, Sergey I., Milovanović, Dubravka S., Radulović, Aleksandra , Panjan, Peter, Ionin, Andrey A., "The morphological and compositional changes of bimetallic Ti/Al thin film induced by ultra-short laser pulses" in European Physical Journal D, 75, no. 11 (2021),
https://doi.org/10.1140/epjd/s10053-021-00292-4 . .

Analysis of lead-based archaeological pottery glazes by laser induced breakdown spectroscopy

Kuzmanović, Miroslav M.; Stancalie, Andrei; Milovanović, Dubravka S.; Staicu, Angela; Damjanović-Vasilić, Ljiljana; Ranković, Dragan; Savović, Jelena

(2021)

TY  - JOUR
AU  - Kuzmanović, Miroslav M.
AU  - Stancalie, Andrei
AU  - Milovanović, Dubravka S.
AU  - Staicu, Angela
AU  - Damjanović-Vasilić, Ljiljana
AU  - Ranković, Dragan
AU  - Savović, Jelena
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9644
AB  - The aim of this study was to demonstrate the potential of Laser-Induced Breakdown Spectroscopy (LIBS) in the analysis of pottery shards, which are commonly the most abundant artefacts recovered at archaeological sites. The analytical capability of LIBS in identification of elements characteristic to inorganic pigments used for decoration was assessed. Based on the specific elements detected in the LIBS spectra of glazes, correlations between the elemental composition of the glaze and the colours of the glazed surface were established. The results were in accordance with the previously reported Energy Dispersive X-ray Fluorescence (EDXRF) and Raman analyses of some of the samples, and with the presently performed XRF analysis. Two important parameters for plasma characterization, temperature and electron number density, were estimated from the spectral data. A potential use of LIBS for depth profiling was also investigated by analysing the silicon to aluminium intensity ratio as a function of the number of laser shots applied. Profilometry analysis of the damages created on the glazed surfaces by laser shots was used to estimate the average ablation depth and ablated mass.
T2  - Optics & Laser Technology
T1  - Analysis of lead-based archaeological pottery glazes by laser induced breakdown spectroscopy
VL  - 134
SP  - 106599
DO  - 10.1016/j.optlastec.2020.106599
ER  - 
@article{
author = "Kuzmanović, Miroslav M. and Stancalie, Andrei and Milovanović, Dubravka S. and Staicu, Angela and Damjanović-Vasilić, Ljiljana and Ranković, Dragan and Savović, Jelena",
year = "2021",
abstract = "The aim of this study was to demonstrate the potential of Laser-Induced Breakdown Spectroscopy (LIBS) in the analysis of pottery shards, which are commonly the most abundant artefacts recovered at archaeological sites. The analytical capability of LIBS in identification of elements characteristic to inorganic pigments used for decoration was assessed. Based on the specific elements detected in the LIBS spectra of glazes, correlations between the elemental composition of the glaze and the colours of the glazed surface were established. The results were in accordance with the previously reported Energy Dispersive X-ray Fluorescence (EDXRF) and Raman analyses of some of the samples, and with the presently performed XRF analysis. Two important parameters for plasma characterization, temperature and electron number density, were estimated from the spectral data. A potential use of LIBS for depth profiling was also investigated by analysing the silicon to aluminium intensity ratio as a function of the number of laser shots applied. Profilometry analysis of the damages created on the glazed surfaces by laser shots was used to estimate the average ablation depth and ablated mass.",
journal = "Optics & Laser Technology",
title = "Analysis of lead-based archaeological pottery glazes by laser induced breakdown spectroscopy",
volume = "134",
pages = "106599",
doi = "10.1016/j.optlastec.2020.106599"
}
Kuzmanović, M. M., Stancalie, A., Milovanović, D. S., Staicu, A., Damjanović-Vasilić, L., Ranković, D.,& Savović, J.. (2021). Analysis of lead-based archaeological pottery glazes by laser induced breakdown spectroscopy. in Optics & Laser Technology, 134, 106599.
https://doi.org/10.1016/j.optlastec.2020.106599
Kuzmanović MM, Stancalie A, Milovanović DS, Staicu A, Damjanović-Vasilić L, Ranković D, Savović J. Analysis of lead-based archaeological pottery glazes by laser induced breakdown spectroscopy. in Optics & Laser Technology. 2021;134:106599.
doi:10.1016/j.optlastec.2020.106599 .
Kuzmanović, Miroslav M., Stancalie, Andrei, Milovanović, Dubravka S., Staicu, Angela, Damjanović-Vasilić, Ljiljana, Ranković, Dragan, Savović, Jelena, "Analysis of lead-based archaeological pottery glazes by laser induced breakdown spectroscopy" in Optics & Laser Technology, 134 (2021):106599,
https://doi.org/10.1016/j.optlastec.2020.106599 . .

Walnut Supplementation Restores the SIRT1-FoxO3a-MnSOD/Catalase Axis in the Heart, Promotes an Anti-Inflammatory Fatty Acid Profile in Plasma, and Lowers Blood Pressure on Fructose-Rich Diet

Bošković, Maja; Živković, Maja; Korićanac, Goran; Stanišić, Jelena; Zec, Manja; Krga, Irena S.; Stanković, Aleksandra

(2021)

TY  - JOUR
AU  - Bošković, Maja
AU  - Živković, Maja
AU  - Korićanac, Goran
AU  - Stanišić, Jelena
AU  - Zec, Manja
AU  - Krga, Irena S.
AU  - Stanković, Aleksandra
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9809
AB  - The benefits of walnut (Juglans regia) consumption for metabolic health are known, but the molecular background underlying their putative antioxidant and anti-inflammatory/immunomodulatory effects is underexplored. We assessed that walnut supplementation (6 weeks) reverted unfavorable changes of the SIRT1/FoxO3a/MnSOD/catalase axis in the heart induced by fructose-rich diet (FRD). Intriguingly, Nox4 was increased by both FRD and walnut supplementation. FRD increased the cytosolic fraction and decreased the nuclear fraction of the uniquely elucidated ChREBP in the heart. The ChREBP nuclear fraction was decreased in control rats subjected to walnuts. In addition, walnut consumption was associated with a reduction in systolic BP in FRD and a decrease in fatty acid AA/EPA and AA/DHA ratios in plasma. In summary, the protective effect of walnut supplementation was detected in male rats following the fructose-induced decrease in antioxidative/anti-inflammatory capacity of cardiac tissue and increase in plasma predictors of low-grade inflammation. The current results provide a novel insight into the relationship between nutrients, cellular energy homeostasis, and the modulators of inflammatory/immune response in metabolic syndrome, emphasizing the heart and highlighting a track for translation into nutrition and dietary therapeutic approaches against metabolic disease.
T2  - Oxidative Medicine and Cellular Longevity
T1  - Walnut Supplementation Restores the SIRT1-FoxO3a-MnSOD/Catalase Axis in the Heart, Promotes an Anti-Inflammatory Fatty Acid Profile in Plasma, and Lowers Blood Pressure on Fructose-Rich Diet
VL  - 2021
SP  - e5543025
DO  - 10.1155/2021/5543025
ER  - 
@article{
author = "Bošković, Maja and Živković, Maja and Korićanac, Goran and Stanišić, Jelena and Zec, Manja and Krga, Irena S. and Stanković, Aleksandra",
year = "2021",
abstract = "The benefits of walnut (Juglans regia) consumption for metabolic health are known, but the molecular background underlying their putative antioxidant and anti-inflammatory/immunomodulatory effects is underexplored. We assessed that walnut supplementation (6 weeks) reverted unfavorable changes of the SIRT1/FoxO3a/MnSOD/catalase axis in the heart induced by fructose-rich diet (FRD). Intriguingly, Nox4 was increased by both FRD and walnut supplementation. FRD increased the cytosolic fraction and decreased the nuclear fraction of the uniquely elucidated ChREBP in the heart. The ChREBP nuclear fraction was decreased in control rats subjected to walnuts. In addition, walnut consumption was associated with a reduction in systolic BP in FRD and a decrease in fatty acid AA/EPA and AA/DHA ratios in plasma. In summary, the protective effect of walnut supplementation was detected in male rats following the fructose-induced decrease in antioxidative/anti-inflammatory capacity of cardiac tissue and increase in plasma predictors of low-grade inflammation. The current results provide a novel insight into the relationship between nutrients, cellular energy homeostasis, and the modulators of inflammatory/immune response in metabolic syndrome, emphasizing the heart and highlighting a track for translation into nutrition and dietary therapeutic approaches against metabolic disease.",
journal = "Oxidative Medicine and Cellular Longevity",
title = "Walnut Supplementation Restores the SIRT1-FoxO3a-MnSOD/Catalase Axis in the Heart, Promotes an Anti-Inflammatory Fatty Acid Profile in Plasma, and Lowers Blood Pressure on Fructose-Rich Diet",
volume = "2021",
pages = "e5543025",
doi = "10.1155/2021/5543025"
}
Bošković, M., Živković, M., Korićanac, G., Stanišić, J., Zec, M., Krga, I. S.,& Stanković, A.. (2021). Walnut Supplementation Restores the SIRT1-FoxO3a-MnSOD/Catalase Axis in the Heart, Promotes an Anti-Inflammatory Fatty Acid Profile in Plasma, and Lowers Blood Pressure on Fructose-Rich Diet. in Oxidative Medicine and Cellular Longevity, 2021, e5543025.
https://doi.org/10.1155/2021/5543025
Bošković M, Živković M, Korićanac G, Stanišić J, Zec M, Krga IS, Stanković A. Walnut Supplementation Restores the SIRT1-FoxO3a-MnSOD/Catalase Axis in the Heart, Promotes an Anti-Inflammatory Fatty Acid Profile in Plasma, and Lowers Blood Pressure on Fructose-Rich Diet. in Oxidative Medicine and Cellular Longevity. 2021;2021:e5543025.
doi:10.1155/2021/5543025 .
Bošković, Maja, Živković, Maja, Korićanac, Goran, Stanišić, Jelena, Zec, Manja, Krga, Irena S., Stanković, Aleksandra, "Walnut Supplementation Restores the SIRT1-FoxO3a-MnSOD/Catalase Axis in the Heart, Promotes an Anti-Inflammatory Fatty Acid Profile in Plasma, and Lowers Blood Pressure on Fructose-Rich Diet" in Oxidative Medicine and Cellular Longevity, 2021 (2021):e5543025,
https://doi.org/10.1155/2021/5543025 . .
2
1

The association of glutathione S-transferase T1 and M1 deletions with myocardial infarction

Živković, Maja; Bubić, Maja; Kolaković, Ana; Dekleva, Milica; Stanković, Goran; Stanković, Aleksandra; Đurić, Tamara

(2021)

TY  - JOUR
AU  - Živković, Maja
AU  - Bubić, Maja
AU  - Kolaković, Ana
AU  - Dekleva, Milica
AU  - Stanković, Goran
AU  - Stanković, Aleksandra
AU  - Đurić, Tamara
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9842
AB  - Glutathione S-transferases (GSTs) are the family of enzymes involved in the second line of defense against oxidative stress (OS). The lack of GSTT1/GSTM1 enzyme quantity or activity, due to the presence of homozygous deletion compromises antioxidative defense resulting in OS. OS is the critical mechanism in the pathophysiology of atherosclerosis, coronary artery disease, and myocardial infarction (MI). The increase in reactive oxygen species together with the process of apoptosis plays a role in left ventricular remodeling (LVR) after MI. The associations of GSTT1 and GSTM1 gene polymorphisms with the risk of MI are inconsistent. The aim was to analyze the association of GSTT1/GSTM1 null genotypes with first MI and LVR 8 months after the MI. The study involved 330 controls and 438 consecutive patients with symptoms and signs of first MI. The subgroup of 150 MI patients was prospectively followed up for 6 months. Evidence of maladaptive LVR was obtained by 2D Doppler echocardiography 3-5 days and 6 months after the MI. A multiplex polymerase chain reaction was used to detect the deletion in GSTT1 and GSTM1 genes. GSTM1 null genotype was significantly and independently associated with first MI (adjusted OR = 1.45 95% CI 1.03-2.03, p = 0.03). Association of double null genotypes with maladaptive LVR in patients 6 months after the first MI was no longer significant after adjustment for factors that differed significantly between patients with and without maladaptive LVR. This study demonstrated the association of GSTM1 null genotypes with the risk of MI in the Serbian population.
T2  - Free Radical Research
T1  - The association of glutathione S-transferase T1 and M1 deletions with myocardial infarction
VL  - 55
IS  - 3
SP  - 267
EP  - 274
DO  - 10.1080/10715762.2021.1931166
ER  - 
@article{
author = "Živković, Maja and Bubić, Maja and Kolaković, Ana and Dekleva, Milica and Stanković, Goran and Stanković, Aleksandra and Đurić, Tamara",
year = "2021",
abstract = "Glutathione S-transferases (GSTs) are the family of enzymes involved in the second line of defense against oxidative stress (OS). The lack of GSTT1/GSTM1 enzyme quantity or activity, due to the presence of homozygous deletion compromises antioxidative defense resulting in OS. OS is the critical mechanism in the pathophysiology of atherosclerosis, coronary artery disease, and myocardial infarction (MI). The increase in reactive oxygen species together with the process of apoptosis plays a role in left ventricular remodeling (LVR) after MI. The associations of GSTT1 and GSTM1 gene polymorphisms with the risk of MI are inconsistent. The aim was to analyze the association of GSTT1/GSTM1 null genotypes with first MI and LVR 8 months after the MI. The study involved 330 controls and 438 consecutive patients with symptoms and signs of first MI. The subgroup of 150 MI patients was prospectively followed up for 6 months. Evidence of maladaptive LVR was obtained by 2D Doppler echocardiography 3-5 days and 6 months after the MI. A multiplex polymerase chain reaction was used to detect the deletion in GSTT1 and GSTM1 genes. GSTM1 null genotype was significantly and independently associated with first MI (adjusted OR = 1.45 95% CI 1.03-2.03, p = 0.03). Association of double null genotypes with maladaptive LVR in patients 6 months after the first MI was no longer significant after adjustment for factors that differed significantly between patients with and without maladaptive LVR. This study demonstrated the association of GSTM1 null genotypes with the risk of MI in the Serbian population.",
journal = "Free Radical Research",
title = "The association of glutathione S-transferase T1 and M1 deletions with myocardial infarction",
volume = "55",
number = "3",
pages = "267-274",
doi = "10.1080/10715762.2021.1931166"
}
Živković, M., Bubić, M., Kolaković, A., Dekleva, M., Stanković, G., Stanković, A.,& Đurić, T.. (2021). The association of glutathione S-transferase T1 and M1 deletions with myocardial infarction. in Free Radical Research, 55(3), 267-274.
https://doi.org/10.1080/10715762.2021.1931166
Živković M, Bubić M, Kolaković A, Dekleva M, Stanković G, Stanković A, Đurić T. The association of glutathione S-transferase T1 and M1 deletions with myocardial infarction. in Free Radical Research. 2021;55(3):267-274.
doi:10.1080/10715762.2021.1931166 .
Živković, Maja, Bubić, Maja, Kolaković, Ana, Dekleva, Milica, Stanković, Goran, Stanković, Aleksandra, Đurić, Tamara, "The association of glutathione S-transferase T1 and M1 deletions with myocardial infarction" in Free Radical Research, 55, no. 3 (2021):267-274,
https://doi.org/10.1080/10715762.2021.1931166 . .