TY  - JOUR
AU  - Rakić-Kostić, Tijana M.
AU  - Bogojeski, Jovana V.
AU  - Popović, Iva A.
AU  - Nešić, Maja D.
AU  - Rajčić, Boris
AU  - Nišavić, Marija
AU  - Petković, Marijana
AU  - Veličković, Suzana
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1362
AB  - This paper presents optimization of matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometer (MS) instrumental parameters for the analysis of chloro(2,2 , 2 -terpyridine) palladium(II) chloride dihydrate complex applying design of experiments methodology (DoE). This complex is of interest for potential use in the cancer therapy. DoE methodology was proved to succeed in optimization of many complex analytical problems. However, it has been poorly used for MALDI-TOF-MS optimization up to now. The theoretical mathematical relationships which explain the influence of important experimental factors (laser energy, grid voltage and number of laser shots) on the selected responses (signal to noise - S/N ratio and the resolution - R of the leading peak) is established. The optimal instrumental settings providing maximal S/N and R are identified and experimentally verified.
T2  - Hemijska industrija
T1  - Experimental design for optimizing MALDI-TOF-MS analysis of palladium complexes
VL  - 71
IS  - 4
SP  - 281
EP  - 288
DO  - 10.2298/HEMIND160614038R
ER  - 

@article{
author = "Rakić-Kostić, Tijana M. and Bogojeski, Jovana V. and Popović, Iva A. and Nešić, Maja D. and Rajčić, Boris and Nišavić, Marija and Petković, Marijana and Veličković, Suzana",
year = "2017",
abstract = "This paper presents optimization of matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometer (MS) instrumental parameters for the analysis of chloro(2,2 , 2 -terpyridine) palladium(II) chloride dihydrate complex applying design of experiments methodology (DoE). This complex is of interest for potential use in the cancer therapy. DoE methodology was proved to succeed in optimization of many complex analytical problems. However, it has been poorly used for MALDI-TOF-MS optimization up to now. The theoretical mathematical relationships which explain the influence of important experimental factors (laser energy, grid voltage and number of laser shots) on the selected responses (signal to noise - S/N ratio and the resolution - R of the leading peak) is established. The optimal instrumental settings providing maximal S/N and R are identified and experimentally verified.",
journal = "Hemijska industrija",
title = "Experimental design for optimizing MALDI-TOF-MS analysis of palladium complexes",
volume = "71",
number = "4",
pages = "281-288",
doi = "10.2298/HEMIND160614038R"
}

Rakić-Kostić, T. M., Bogojeski, J. V., Popović, I. A., Nešić, M. D., Rajčić, B., Nišavić, M., Petković, M.,& Veličković, S.. (2017). Experimental design for optimizing MALDI-TOF-MS analysis of palladium complexes. in Hemijska industrija, 71(4), 281-288.
https://doi.org/10.2298/HEMIND160614038R

Rakić-Kostić TM, Bogojeski JV, Popović IA, Nešić MD, Rajčić B, Nišavić M, Petković M, Veličković S. Experimental design for optimizing MALDI-TOF-MS analysis of palladium complexes. in Hemijska industrija. 2017;71(4):281-288.
doi:10.2298/HEMIND160614038R .

Rakić-Kostić, Tijana M., Bogojeski, Jovana V., Popović, Iva A., Nešić, Maja D., Rajčić, Boris, Nišavić, Marija, Petković, Marijana, Veličković, Suzana, "Experimental design for optimizing MALDI-TOF-MS analysis of palladium complexes" in Hemijska industrija, 71, no. 4 (2017):281-288,
https://doi.org/10.2298/HEMIND160614038R . .