Molecular mechanisms of redox signalling in homeostasis: adaptation and pathology

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Molecular mechanisms of redox signalling in homeostasis: adaptation and pathology (en)
Молекуларни механизми редокс сигналинга у хомеостази, адаптацији и патологији (sr)
Molekularni mehanizmi redoks signalinga u homeostazi, adaptaciji i patologiji (sr_RS)
Authors

Publications

Protective effects of whey on rat liver damage induced by chronic alcohol intake

Radić, Ivan; Mijović, Milica; Tatalović, Nikola R.; Mitić, Miloš; Lukić, Vera; Joksimović, Bojan; Petrović, Zorica; Ristić, Siniša; Veličković, Stefan; Nestorović, Vojkan; Ćorac, Aleksandar M.; Mirić, Mirjana; Adžić, Miroslav; Blagojević, Duško P.; Popović, Ljiljana M.; Janićijević-Hudomal, Snežana

(2019)

TY  - JOUR
AU  - Radić, Ivan
AU  - Mijović, Milica
AU  - Tatalović, Nikola R.
AU  - Mitić, Miloš
AU  - Lukić, Vera
AU  - Joksimović, Bojan
AU  - Petrović, Zorica
AU  - Ristić, Siniša
AU  - Veličković, Stefan
AU  - Nestorović, Vojkan
AU  - Ćorac, Aleksandar M.
AU  - Mirić, Mirjana
AU  - Adžić, Miroslav
AU  - Blagojević, Duško P.
AU  - Popović, Ljiljana M.
AU  - Janićijević-Hudomal, Snežana
PY  - 2019
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/8541
AB  - In 2012, alcohol liver disease resulted in 3.3 million—5.9% of global deaths. This study introduced whey protection capacity against chronic alcohol-induced liver injury. Rats were orally administered to 12% ethanol solution in water (ad libitum, average 8.14 g of ethanol/kg body weight (b.w.)/day) alone or combined with whey (per os, 2 g/kg b.w./day). After 6-week treatment, chronic ethanol consumption induced significant histopathological liver changes: congestion, central vein dilation, hepatic portal vein branch dilation, Kupffer cells hyperplasia, fatty liver changes, and hepatocytes focal necrosis. Ethanol significantly increased liver catalase activity and glutathione reductase protein expression without significant effects on antioxidative enzymes: glutathione peroxidase (GPx), copper–zinc-containing superoxide dismutase (CuZnSOD) and manganese-containing superoxide dismutase (MnSOD). Co-treatment with whey significantly attenuated pathohistological changes induced by ethanol ingestion and increased GSH-Px and nuclear factor kappa B (NF-κB) protein expression. Our results showed positive effects of whey on liver chronically exposed to ethanol, which seem to be associated with NF-κB-GPx signaling. © The Author(s) 2019.
T2  - Human & Experimental Toxicology
T1  - Protective effects of whey on rat liver damage induced by chronic alcohol intake
VL  - 38
IS  - 6
SP  - 632
EP  - 645
DO  - 10.1177/0960327119829518
ER  - 
@article{
author = "Radić, Ivan and Mijović, Milica and Tatalović, Nikola R. and Mitić, Miloš and Lukić, Vera and Joksimović, Bojan and Petrović, Zorica and Ristić, Siniša and Veličković, Stefan and Nestorović, Vojkan and Ćorac, Aleksandar M. and Mirić, Mirjana and Adžić, Miroslav and Blagojević, Duško P. and Popović, Ljiljana M. and Janićijević-Hudomal, Snežana",
year = "2019",
abstract = "In 2012, alcohol liver disease resulted in 3.3 million—5.9% of global deaths. This study introduced whey protection capacity against chronic alcohol-induced liver injury. Rats were orally administered to 12% ethanol solution in water (ad libitum, average 8.14 g of ethanol/kg body weight (b.w.)/day) alone or combined with whey (per os, 2 g/kg b.w./day). After 6-week treatment, chronic ethanol consumption induced significant histopathological liver changes: congestion, central vein dilation, hepatic portal vein branch dilation, Kupffer cells hyperplasia, fatty liver changes, and hepatocytes focal necrosis. Ethanol significantly increased liver catalase activity and glutathione reductase protein expression without significant effects on antioxidative enzymes: glutathione peroxidase (GPx), copper–zinc-containing superoxide dismutase (CuZnSOD) and manganese-containing superoxide dismutase (MnSOD). Co-treatment with whey significantly attenuated pathohistological changes induced by ethanol ingestion and increased GSH-Px and nuclear factor kappa B (NF-κB) protein expression. Our results showed positive effects of whey on liver chronically exposed to ethanol, which seem to be associated with NF-κB-GPx signaling. © The Author(s) 2019.",
journal = "Human & Experimental Toxicology",
title = "Protective effects of whey on rat liver damage induced by chronic alcohol intake",
volume = "38",
number = "6",
pages = "632-645",
doi = "10.1177/0960327119829518"
}
Radić, I., Mijović, M., Tatalović, N. R., Mitić, M., Lukić, V., Joksimović, B., Petrović, Z., Ristić, S., Veličković, S., Nestorović, V., Ćorac, A. M., Mirić, M., Adžić, M., Blagojević, D. P., Popović, L. M.,& Janićijević-Hudomal, S.. (2019). Protective effects of whey on rat liver damage induced by chronic alcohol intake. in Human & Experimental Toxicology, 38(6), 632-645.
https://doi.org/10.1177/0960327119829518
Radić I, Mijović M, Tatalović NR, Mitić M, Lukić V, Joksimović B, Petrović Z, Ristić S, Veličković S, Nestorović V, Ćorac AM, Mirić M, Adžić M, Blagojević DP, Popović LM, Janićijević-Hudomal S. Protective effects of whey on rat liver damage induced by chronic alcohol intake. in Human & Experimental Toxicology. 2019;38(6):632-645.
doi:10.1177/0960327119829518 .
Radić, Ivan, Mijović, Milica, Tatalović, Nikola R., Mitić, Miloš, Lukić, Vera, Joksimović, Bojan, Petrović, Zorica, Ristić, Siniša, Veličković, Stefan, Nestorović, Vojkan, Ćorac, Aleksandar M., Mirić, Mirjana, Adžić, Miroslav, Blagojević, Duško P., Popović, Ljiljana M., Janićijević-Hudomal, Snežana, "Protective effects of whey on rat liver damage induced by chronic alcohol intake" in Human & Experimental Toxicology, 38, no. 6 (2019):632-645,
https://doi.org/10.1177/0960327119829518 . .
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Influence of absorbed radiation dose following computed tomography on the antioxidative status in rabbit testicles

Mitrović, Marko B.; Tatalović, Nikola R.; Nikolić-Kokić, Aleksandra L.; Ciraj-Bjelac, Olivera; Krstić, Nikola E.; Oreščanin-Dušić, Zorana S.; Krstić, Dragana Ž.; Jovanović, Zoran M.; Blagojević, Duško P.; Lazarević-Macanović, Mirjana V.

(2018)

TY  - JOUR
AU  - Mitrović, Marko B.
AU  - Tatalović, Nikola R.
AU  - Nikolić-Kokić, Aleksandra L.
AU  - Ciraj-Bjelac, Olivera
AU  - Krstić, Nikola E.
AU  - Oreščanin-Dušić, Zorana S.
AU  - Krstić, Dragana Ž.
AU  - Jovanović, Zoran M.
AU  - Blagojević, Duško P.
AU  - Lazarević-Macanović, Mirjana V.
PY  - 2018
UR  - http://www.doiserbia.nb.rs/Article.aspx?ID=0354-46641800029M
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/8001
AB  - In recent years, computed tomography (CT) has become very common in veterinary medicine. It is well known that testicles are organs with high radiosensitivity and their function can be impaired even after exposure to low radiation doses. In this work, we calculated the absorbed radiation doses after CT was performed with different voltage/current levels and correlated it with the activity of antioxidant enzymes in rabbit testicles. Two hours after CT, the activities of catalase (CAT) and glutathione peroxidase (GSH-Px) were increased in the testicles of animals that received an absorbed dose of 29.2 mGy. The same changes, along with elevated glutathione reductase (GR) activity, were observed after 7 days in animals that received the highest absorbed dose (46.3 mGy). It would appear that absorbed doses above 27.8 mGy provoked the antioxidant reaction but the time scale of the reaction was dose-dependent. Examination of the obtained results revealed that the main denominator of CT influence was a higher current. Our results suggest that CT influences the antioxidant status in rabbit testicles. The changes in antioxidant enzyme activities were dose- and time-dependent and influenced by the applied current. © 2018 by the Serbian Biological Society.
T2  - Archives of Biological Sciences
T1  - Influence of absorbed radiation dose following computed tomography on the antioxidative status in rabbit testicles
VL  - 70
IS  - 4
SP  - 675
EP  - 680
DO  - 10.2298/ABS180413029M
ER  - 
@article{
author = "Mitrović, Marko B. and Tatalović, Nikola R. and Nikolić-Kokić, Aleksandra L. and Ciraj-Bjelac, Olivera and Krstić, Nikola E. and Oreščanin-Dušić, Zorana S. and Krstić, Dragana Ž. and Jovanović, Zoran M. and Blagojević, Duško P. and Lazarević-Macanović, Mirjana V.",
year = "2018",
abstract = "In recent years, computed tomography (CT) has become very common in veterinary medicine. It is well known that testicles are organs with high radiosensitivity and their function can be impaired even after exposure to low radiation doses. In this work, we calculated the absorbed radiation doses after CT was performed with different voltage/current levels and correlated it with the activity of antioxidant enzymes in rabbit testicles. Two hours after CT, the activities of catalase (CAT) and glutathione peroxidase (GSH-Px) were increased in the testicles of animals that received an absorbed dose of 29.2 mGy. The same changes, along with elevated glutathione reductase (GR) activity, were observed after 7 days in animals that received the highest absorbed dose (46.3 mGy). It would appear that absorbed doses above 27.8 mGy provoked the antioxidant reaction but the time scale of the reaction was dose-dependent. Examination of the obtained results revealed that the main denominator of CT influence was a higher current. Our results suggest that CT influences the antioxidant status in rabbit testicles. The changes in antioxidant enzyme activities were dose- and time-dependent and influenced by the applied current. © 2018 by the Serbian Biological Society.",
journal = "Archives of Biological Sciences",
title = "Influence of absorbed radiation dose following computed tomography on the antioxidative status in rabbit testicles",
volume = "70",
number = "4",
pages = "675-680",
doi = "10.2298/ABS180413029M"
}
Mitrović, M. B., Tatalović, N. R., Nikolić-Kokić, A. L., Ciraj-Bjelac, O., Krstić, N. E., Oreščanin-Dušić, Z. S., Krstić, D. Ž., Jovanović, Z. M., Blagojević, D. P.,& Lazarević-Macanović, M. V.. (2018). Influence of absorbed radiation dose following computed tomography on the antioxidative status in rabbit testicles. in Archives of Biological Sciences, 70(4), 675-680.
https://doi.org/10.2298/ABS180413029M
Mitrović MB, Tatalović NR, Nikolić-Kokić AL, Ciraj-Bjelac O, Krstić NE, Oreščanin-Dušić ZS, Krstić DŽ, Jovanović ZM, Blagojević DP, Lazarević-Macanović MV. Influence of absorbed radiation dose following computed tomography on the antioxidative status in rabbit testicles. in Archives of Biological Sciences. 2018;70(4):675-680.
doi:10.2298/ABS180413029M .
Mitrović, Marko B., Tatalović, Nikola R., Nikolić-Kokić, Aleksandra L., Ciraj-Bjelac, Olivera, Krstić, Nikola E., Oreščanin-Dušić, Zorana S., Krstić, Dragana Ž., Jovanović, Zoran M., Blagojević, Duško P., Lazarević-Macanović, Mirjana V., "Influence of absorbed radiation dose following computed tomography on the antioxidative status in rabbit testicles" in Archives of Biological Sciences, 70, no. 4 (2018):675-680,
https://doi.org/10.2298/ABS180413029M . .
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Coordination and redox interactions of β-lactam antibiotics with Cu2+ in physiological settings and the impact on antibacterial activity

Božić, Bojana; Korać, Jelena; Stanković, Dalibor M.; Stanić, Marina; Romanović, Mima Č.; Bogdanović-Pristov, Jelena; Spasić, Snežana D.; Popović-Bijelić, Ana D.; Spasojević, Ivan; Bajčetić, Milica

(2018)

TY  - JOUR
AU  - Božić, Bojana
AU  - Korać, Jelena
AU  - Stanković, Dalibor M.
AU  - Stanić, Marina
AU  - Romanović, Mima Č.
AU  - Bogdanović-Pristov, Jelena
AU  - Spasić, Snežana D.
AU  - Popović-Bijelić, Ana D.
AU  - Spasojević, Ivan
AU  - Bajčetić, Milica
PY  - 2018
UR  - https://linkinghub.elsevier.com/retrieve/pii/S0891584918311213
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/7896
AB  - An increase in the copper pool in body fluids has been related to a number of pathological conditions, including infections. Copper ions may affect antibiotics via the formation of coordination bonds and/or redox reactions. Herein, we analyzed the interactions of Cu2+ with eight β-lactam antibiotics using UV–Vis spectrophotometry, EPR spectroscopy, and electrochemical methods. Penicillin G did not show any detectable interactions with Cu2+. Ampicillin, amoxicillin and cephalexin formed stable colored complexes with octahedral coordination environment of Cu2+ with tetragonal distortion, and primary amine group as the site of coordinate bond formation. These β-lactams increased the solubility of Cu2+ in the phosphate buffer. Ceftazidime and Cu2+ formed a complex with a similar geometry and gave rise to an organic radical. Ceftriaxone-Cu2+ complex appears to exhibit different geometry. All complexes showed 1:1 stoichiometry. Cefaclor reduced Cu2+ to Cu1+ that further reacted with molecular oxygen to produce hydrogen peroxide. Finally, meropenem underwent degradation in the presence of copper. The analysis of activity against Escherichia coli and Staphylococcus aureus showed that the effects of meropenem, amoxicillin, ampicillin, and ceftriaxone were significantly hindered in the presence of copper ions. The interactions with copper ions should be taken into account regarding the problem of antibiotic resistance and in the selection of the most efficient antimicrobial therapy for patients with altered copper homeostasis. © 2018 Elsevier Inc.
T2  - Free Radical Biology and Medicine
T1  - Coordination and redox interactions of β-lactam antibiotics with Cu2+ in physiological settings and the impact on antibacterial activity
VL  - 129
SP  - 279
EP  - 285
DO  - 10.1016/j.freeradbiomed.2018.09.038
ER  - 
@article{
author = "Božić, Bojana and Korać, Jelena and Stanković, Dalibor M. and Stanić, Marina and Romanović, Mima Č. and Bogdanović-Pristov, Jelena and Spasić, Snežana D. and Popović-Bijelić, Ana D. and Spasojević, Ivan and Bajčetić, Milica",
year = "2018",
abstract = "An increase in the copper pool in body fluids has been related to a number of pathological conditions, including infections. Copper ions may affect antibiotics via the formation of coordination bonds and/or redox reactions. Herein, we analyzed the interactions of Cu2+ with eight β-lactam antibiotics using UV–Vis spectrophotometry, EPR spectroscopy, and electrochemical methods. Penicillin G did not show any detectable interactions with Cu2+. Ampicillin, amoxicillin and cephalexin formed stable colored complexes with octahedral coordination environment of Cu2+ with tetragonal distortion, and primary amine group as the site of coordinate bond formation. These β-lactams increased the solubility of Cu2+ in the phosphate buffer. Ceftazidime and Cu2+ formed a complex with a similar geometry and gave rise to an organic radical. Ceftriaxone-Cu2+ complex appears to exhibit different geometry. All complexes showed 1:1 stoichiometry. Cefaclor reduced Cu2+ to Cu1+ that further reacted with molecular oxygen to produce hydrogen peroxide. Finally, meropenem underwent degradation in the presence of copper. The analysis of activity against Escherichia coli and Staphylococcus aureus showed that the effects of meropenem, amoxicillin, ampicillin, and ceftriaxone were significantly hindered in the presence of copper ions. The interactions with copper ions should be taken into account regarding the problem of antibiotic resistance and in the selection of the most efficient antimicrobial therapy for patients with altered copper homeostasis. © 2018 Elsevier Inc.",
journal = "Free Radical Biology and Medicine",
title = "Coordination and redox interactions of β-lactam antibiotics with Cu2+ in physiological settings and the impact on antibacterial activity",
volume = "129",
pages = "279-285",
doi = "10.1016/j.freeradbiomed.2018.09.038"
}
Božić, B., Korać, J., Stanković, D. M., Stanić, M., Romanović, M. Č., Bogdanović-Pristov, J., Spasić, S. D., Popović-Bijelić, A. D., Spasojević, I.,& Bajčetić, M.. (2018). Coordination and redox interactions of β-lactam antibiotics with Cu2+ in physiological settings and the impact on antibacterial activity. in Free Radical Biology and Medicine, 129, 279-285.
https://doi.org/10.1016/j.freeradbiomed.2018.09.038
Božić B, Korać J, Stanković DM, Stanić M, Romanović MČ, Bogdanović-Pristov J, Spasić SD, Popović-Bijelić AD, Spasojević I, Bajčetić M. Coordination and redox interactions of β-lactam antibiotics with Cu2+ in physiological settings and the impact on antibacterial activity. in Free Radical Biology and Medicine. 2018;129:279-285.
doi:10.1016/j.freeradbiomed.2018.09.038 .
Božić, Bojana, Korać, Jelena, Stanković, Dalibor M., Stanić, Marina, Romanović, Mima Č., Bogdanović-Pristov, Jelena, Spasić, Snežana D., Popović-Bijelić, Ana D., Spasojević, Ivan, Bajčetić, Milica, "Coordination and redox interactions of β-lactam antibiotics with Cu2+ in physiological settings and the impact on antibacterial activity" in Free Radical Biology and Medicine, 129 (2018):279-285,
https://doi.org/10.1016/j.freeradbiomed.2018.09.038 . .
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The effects of whey and pumpkin seed oil on blood biochemical parameters of liver function and lipid profile in rats chronically drinking low concentrations of ethanol

Radić, Ivan; Nestorović, Vojkan; Mijović, Milica; Tatalović, Nikola R.; Joksimović, Bojan; Lukić, Vera; Mitić, Miloš; Adžić, Miroslav; Blagojević, Duško P.; Veličković, Stefan; Bulajić, Sonja; Đerković, Branislav; Mirić, Mirjana; Janićijević-Hudomal, Snežana

(2018)

TY  - JOUR
AU  - Radić, Ivan
AU  - Nestorović, Vojkan
AU  - Mijović, Milica
AU  - Tatalović, Nikola R.
AU  - Joksimović, Bojan
AU  - Lukić, Vera
AU  - Mitić, Miloš
AU  - Adžić, Miroslav
AU  - Blagojević, Duško P.
AU  - Veličković, Stefan
AU  - Bulajić, Sonja
AU  - Đerković, Branislav
AU  - Mirić, Mirjana
AU  - Janićijević-Hudomal, Snežana
PY  - 2018
UR  - http://www.doiserbia.nb.rs/Article.aspx?ID=0354-46641800014R
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/7931
AB  - We studied the effects of whey and pumpkin seed oil supplementation on the biochemical parameters in blood serum of male rats after chronic ad libitum alcohol consumption. The levels of AST, ALT, total bilirubin, ALP, LDH, triglycerides, total cholesterol, HDL, LDL, VLDL, triglyceride/HDL ratio, total cholesterol/HDL ratio (cholesterol ratio) and LDL/HDL ratio (index of atherosclerosis) were determined in rats after six weeks of treatment with: (i) ethanol (12% ethanol, ad libitum), (ii) whey (2 g/kg per day), (iii) pumpkin seed oil (2 mL/kg per day), (iv) both ethanol and whey, and (v) both ethanol and pumpkin seed oil. The results showed no changes in the levels of AST, ALT, total bilirubin, ALP, total cholesterol, HDL and VLDL in alcoholic rats when compared to the controls (fed with a standard laboratory diet ad libitum) and rats supplemented with whey and pumpkin seed oil. Our results suggest that alcohol consumption in small doses for 6 weeks changes lipid metabolism and significantly elevates the LDL/HDL ratio (index of atherosclerosis) but does not induce extensive liver damage. Ethanol consumption in our experimental conditions lowered the triglyceride level as well as the triglyceride/HDL ratio, suggesting lipid redistribution and the induction of some cardio-protective effect. However, ethanol induced a higher index of atherosclerosis. Pumpkin seed oil showed some protective potential in alcoholic rats by lowering the total cholesterol/HDL ratio, but it elevated the LDH. Whey consumption prevented elevation of the atherosclerosis index, pointing to its protective role, probably through the redistribution of lipids. However, whey in combination with ethanol elevated LDH.
T2  - Archives of Biological Sciences
T1  - The effects of whey and pumpkin seed oil on blood biochemical parameters of liver function and lipid profile in rats chronically drinking low concentrations of ethanol
VL  - 70
IS  - 3
SP  - 531
EP  - 541
DO  - 10.2298/ABS180320014R
ER  - 
@article{
author = "Radić, Ivan and Nestorović, Vojkan and Mijović, Milica and Tatalović, Nikola R. and Joksimović, Bojan and Lukić, Vera and Mitić, Miloš and Adžić, Miroslav and Blagojević, Duško P. and Veličković, Stefan and Bulajić, Sonja and Đerković, Branislav and Mirić, Mirjana and Janićijević-Hudomal, Snežana",
year = "2018",
abstract = "We studied the effects of whey and pumpkin seed oil supplementation on the biochemical parameters in blood serum of male rats after chronic ad libitum alcohol consumption. The levels of AST, ALT, total bilirubin, ALP, LDH, triglycerides, total cholesterol, HDL, LDL, VLDL, triglyceride/HDL ratio, total cholesterol/HDL ratio (cholesterol ratio) and LDL/HDL ratio (index of atherosclerosis) were determined in rats after six weeks of treatment with: (i) ethanol (12% ethanol, ad libitum), (ii) whey (2 g/kg per day), (iii) pumpkin seed oil (2 mL/kg per day), (iv) both ethanol and whey, and (v) both ethanol and pumpkin seed oil. The results showed no changes in the levels of AST, ALT, total bilirubin, ALP, total cholesterol, HDL and VLDL in alcoholic rats when compared to the controls (fed with a standard laboratory diet ad libitum) and rats supplemented with whey and pumpkin seed oil. Our results suggest that alcohol consumption in small doses for 6 weeks changes lipid metabolism and significantly elevates the LDL/HDL ratio (index of atherosclerosis) but does not induce extensive liver damage. Ethanol consumption in our experimental conditions lowered the triglyceride level as well as the triglyceride/HDL ratio, suggesting lipid redistribution and the induction of some cardio-protective effect. However, ethanol induced a higher index of atherosclerosis. Pumpkin seed oil showed some protective potential in alcoholic rats by lowering the total cholesterol/HDL ratio, but it elevated the LDH. Whey consumption prevented elevation of the atherosclerosis index, pointing to its protective role, probably through the redistribution of lipids. However, whey in combination with ethanol elevated LDH.",
journal = "Archives of Biological Sciences",
title = "The effects of whey and pumpkin seed oil on blood biochemical parameters of liver function and lipid profile in rats chronically drinking low concentrations of ethanol",
volume = "70",
number = "3",
pages = "531-541",
doi = "10.2298/ABS180320014R"
}
Radić, I., Nestorović, V., Mijović, M., Tatalović, N. R., Joksimović, B., Lukić, V., Mitić, M., Adžić, M., Blagojević, D. P., Veličković, S., Bulajić, S., Đerković, B., Mirić, M.,& Janićijević-Hudomal, S.. (2018). The effects of whey and pumpkin seed oil on blood biochemical parameters of liver function and lipid profile in rats chronically drinking low concentrations of ethanol. in Archives of Biological Sciences, 70(3), 531-541.
https://doi.org/10.2298/ABS180320014R
Radić I, Nestorović V, Mijović M, Tatalović NR, Joksimović B, Lukić V, Mitić M, Adžić M, Blagojević DP, Veličković S, Bulajić S, Đerković B, Mirić M, Janićijević-Hudomal S. The effects of whey and pumpkin seed oil on blood biochemical parameters of liver function and lipid profile in rats chronically drinking low concentrations of ethanol. in Archives of Biological Sciences. 2018;70(3):531-541.
doi:10.2298/ABS180320014R .
Radić, Ivan, Nestorović, Vojkan, Mijović, Milica, Tatalović, Nikola R., Joksimović, Bojan, Lukić, Vera, Mitić, Miloš, Adžić, Miroslav, Blagojević, Duško P., Veličković, Stefan, Bulajić, Sonja, Đerković, Branislav, Mirić, Mirjana, Janićijević-Hudomal, Snežana, "The effects of whey and pumpkin seed oil on blood biochemical parameters of liver function and lipid profile in rats chronically drinking low concentrations of ethanol" in Archives of Biological Sciences, 70, no. 3 (2018):531-541,
https://doi.org/10.2298/ABS180320014R . .
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Influence of Radiation Dose in Computed Tomography on Antioxidant Enzyme Activity in Rabbit Erythrocytes

Mitrović, Marko B.; Ciraj-Bjelac, Olivera; Oreščanin-Dušić, Zorana S.; Blagojević, Duško P.; Nikolić-Kokić, Aleksandra L.; Tatalović, Nikola R.; Krstić, Nikola E.; Lazarević-Macanović, Mirjana V.

(2017)

TY  - JOUR
AU  - Mitrović, Marko B.
AU  - Ciraj-Bjelac, Olivera
AU  - Oreščanin-Dušić, Zorana S.
AU  - Blagojević, Duško P.
AU  - Nikolić-Kokić, Aleksandra L.
AU  - Tatalović, Nikola R.
AU  - Krstić, Nikola E.
AU  - Lazarević-Macanović, Mirjana V.
PY  - 2017
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/1934
AB  - The objective of this study was to assess the radiation dose in computed tomography examinations of rabbits using different examination protocols and to correlate these values with the activity of antioxidant enzymes in their red blood cells following irradiation. The presented results revealed that a single, routine computed tomography scan exposure led to a different response of the activity of antioxidant enzymes in red blood cells regarding both dose and time. The results indicate that there is a dose threshold that is about 25 mGy. Doses below that level do not produce any significant changes in the level of antioxidant enzymes activity. On the other hand, the level just above that threshold had a significant impact on the antioxidant defence, but in a relatively short time period (2 hours after exposure), compared to the higher dose that requires a longer adaptive period.
T2  - Nuclear technology and radiation protection
T1  - Influence of Radiation Dose in Computed Tomography on Antioxidant Enzyme Activity in Rabbit Erythrocytes
VL  - 32
IS  - 4
SP  - 342
EP  - 349
DO  - 10.2298/NTRP1704342M
ER  - 
@article{
author = "Mitrović, Marko B. and Ciraj-Bjelac, Olivera and Oreščanin-Dušić, Zorana S. and Blagojević, Duško P. and Nikolić-Kokić, Aleksandra L. and Tatalović, Nikola R. and Krstić, Nikola E. and Lazarević-Macanović, Mirjana V.",
year = "2017",
abstract = "The objective of this study was to assess the radiation dose in computed tomography examinations of rabbits using different examination protocols and to correlate these values with the activity of antioxidant enzymes in their red blood cells following irradiation. The presented results revealed that a single, routine computed tomography scan exposure led to a different response of the activity of antioxidant enzymes in red blood cells regarding both dose and time. The results indicate that there is a dose threshold that is about 25 mGy. Doses below that level do not produce any significant changes in the level of antioxidant enzymes activity. On the other hand, the level just above that threshold had a significant impact on the antioxidant defence, but in a relatively short time period (2 hours after exposure), compared to the higher dose that requires a longer adaptive period.",
journal = "Nuclear technology and radiation protection",
title = "Influence of Radiation Dose in Computed Tomography on Antioxidant Enzyme Activity in Rabbit Erythrocytes",
volume = "32",
number = "4",
pages = "342-349",
doi = "10.2298/NTRP1704342M"
}
Mitrović, M. B., Ciraj-Bjelac, O., Oreščanin-Dušić, Z. S., Blagojević, D. P., Nikolić-Kokić, A. L., Tatalović, N. R., Krstić, N. E.,& Lazarević-Macanović, M. V.. (2017). Influence of Radiation Dose in Computed Tomography on Antioxidant Enzyme Activity in Rabbit Erythrocytes. in Nuclear technology and radiation protection, 32(4), 342-349.
https://doi.org/10.2298/NTRP1704342M
Mitrović MB, Ciraj-Bjelac O, Oreščanin-Dušić ZS, Blagojević DP, Nikolić-Kokić AL, Tatalović NR, Krstić NE, Lazarević-Macanović MV. Influence of Radiation Dose in Computed Tomography on Antioxidant Enzyme Activity in Rabbit Erythrocytes. in Nuclear technology and radiation protection. 2017;32(4):342-349.
doi:10.2298/NTRP1704342M .
Mitrović, Marko B., Ciraj-Bjelac, Olivera, Oreščanin-Dušić, Zorana S., Blagojević, Duško P., Nikolić-Kokić, Aleksandra L., Tatalović, Nikola R., Krstić, Nikola E., Lazarević-Macanović, Mirjana V., "Influence of Radiation Dose in Computed Tomography on Antioxidant Enzyme Activity in Rabbit Erythrocytes" in Nuclear technology and radiation protection, 32, no. 4 (2017):342-349,
https://doi.org/10.2298/NTRP1704342M . .
1
1

Mechanisms of redox interactions of bilirubin with copper and the effects of penicillamine

Božić, Bojana; Korać, Jelena; Stanković, Dalibor M.; Stanić, Marina; Popović-Bijelić, Ana D.; Bogdanović-Pristov, Jelena; Spasojević, Ivan; Bajčetić, Milica

(2017)

TY  - JOUR
AU  - Božić, Bojana
AU  - Korać, Jelena
AU  - Stanković, Dalibor M.
AU  - Stanić, Marina
AU  - Popović-Bijelić, Ana D.
AU  - Bogdanović-Pristov, Jelena
AU  - Spasojević, Ivan
AU  - Bajčetić, Milica
PY  - 2017
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/1878
AB  - Toxic effects of unconjugated bilirubin (BR) in neonatal hyperbilirubinemia have been related to redox and/or coordinate interactions with Cu2+. However, the development and mechanisms of such interactions at physiological pH have not been resolved. This study shows that BR reduces Cu2+ to Cu1+ in 1:1 stoichiometry. Apparently, BR undergoes degradation, i.e. BR and Cu2+ do not form stable complexes. The binding of Cu2+ to inorganic phosphates, liposomal phosphate groups, or to chelating drug penicillamine, impedes redox interactions with BR. Cu1+ undergoes spontaneous oxidation by O-2 resulting in hydrogen peroxide accumulation and hydroxyl radical production. In relation to this, copper and BR induced synergistic oxidative/damaging effects on erythrocytes membrane, which were alleviated by penicillamine. The production of reactive oxygen species by BR and copper represents a plausible cause of BR toxic effects and cell damage in hyperbilirubinemia. Further examination of therapeutic potentials of copper chelators in the treatment of severe neonatal hyperbilirubinemia is needed.
T2  - Chemico-biological Interactions
T1  - Mechanisms of redox interactions of bilirubin with copper and the effects of penicillamine
VL  - 278
SP  - 129
EP  - 134
DO  - 10.1016/j.cbi.2017.10.022
ER  - 
@article{
author = "Božić, Bojana and Korać, Jelena and Stanković, Dalibor M. and Stanić, Marina and Popović-Bijelić, Ana D. and Bogdanović-Pristov, Jelena and Spasojević, Ivan and Bajčetić, Milica",
year = "2017",
abstract = "Toxic effects of unconjugated bilirubin (BR) in neonatal hyperbilirubinemia have been related to redox and/or coordinate interactions with Cu2+. However, the development and mechanisms of such interactions at physiological pH have not been resolved. This study shows that BR reduces Cu2+ to Cu1+ in 1:1 stoichiometry. Apparently, BR undergoes degradation, i.e. BR and Cu2+ do not form stable complexes. The binding of Cu2+ to inorganic phosphates, liposomal phosphate groups, or to chelating drug penicillamine, impedes redox interactions with BR. Cu1+ undergoes spontaneous oxidation by O-2 resulting in hydrogen peroxide accumulation and hydroxyl radical production. In relation to this, copper and BR induced synergistic oxidative/damaging effects on erythrocytes membrane, which were alleviated by penicillamine. The production of reactive oxygen species by BR and copper represents a plausible cause of BR toxic effects and cell damage in hyperbilirubinemia. Further examination of therapeutic potentials of copper chelators in the treatment of severe neonatal hyperbilirubinemia is needed.",
journal = "Chemico-biological Interactions",
title = "Mechanisms of redox interactions of bilirubin with copper and the effects of penicillamine",
volume = "278",
pages = "129-134",
doi = "10.1016/j.cbi.2017.10.022"
}
Božić, B., Korać, J., Stanković, D. M., Stanić, M., Popović-Bijelić, A. D., Bogdanović-Pristov, J., Spasojević, I.,& Bajčetić, M.. (2017). Mechanisms of redox interactions of bilirubin with copper and the effects of penicillamine. in Chemico-biological Interactions, 278, 129-134.
https://doi.org/10.1016/j.cbi.2017.10.022
Božić B, Korać J, Stanković DM, Stanić M, Popović-Bijelić AD, Bogdanović-Pristov J, Spasojević I, Bajčetić M. Mechanisms of redox interactions of bilirubin with copper and the effects of penicillamine. in Chemico-biological Interactions. 2017;278:129-134.
doi:10.1016/j.cbi.2017.10.022 .
Božić, Bojana, Korać, Jelena, Stanković, Dalibor M., Stanić, Marina, Popović-Bijelić, Ana D., Bogdanović-Pristov, Jelena, Spasojević, Ivan, Bajčetić, Milica, "Mechanisms of redox interactions of bilirubin with copper and the effects of penicillamine" in Chemico-biological Interactions, 278 (2017):129-134,
https://doi.org/10.1016/j.cbi.2017.10.022 . .
3
2
3

Fullerenol C-60(OH)(24) nanoparticles decrease relaxing effects of dimethyl sulfoxide on rat uterus spontaneous contraction

Slavic, Marija; Đorđević, Aleksandar N.; Radojicic, Ratko; Milovanović, Slobodan; Oreščanin-Dušić, Zorana S.; Rakočević, Zlatko Lj.; Spasic, Mihajlo B.; Blagojević, Duško P.

(2013)

TY  - JOUR
AU  - Slavic, Marija
AU  - Đorđević, Aleksandar N.
AU  - Radojicic, Ratko
AU  - Milovanović, Slobodan
AU  - Oreščanin-Dušić, Zorana S.
AU  - Rakočević, Zlatko Lj.
AU  - Spasic, Mihajlo B.
AU  - Blagojević, Duško P.
PY  - 2013
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/5496
AB  - Dimethyl sulfoxide (DMSO) is a widely used solvent and cryoprotectant that can cause impaired blood flow, reduction in intracranial pressure, tissue edema, inflammatory reactions, inhibition of vascular smooth muscle cell migration and proliferation, processes which can lead to atherosclerosis of the coronary, peripheral and cerebral circulation. Although the adverse effects are rare when DMSO is administered in clinically established concentrations, there is no safe antagonist for an overdose. In this work, we treated isolated spontaneous and calcium-induced contractile active rat uteri (Wistar, virgo intacta), with DMSO and fullerenol C-60(OH)(24) nanoparticle (FNP) in DMSO. FNP is a water-soluble derivative of fullerene C-60. Its size is a 1.1 nm in diameter and is a very promising candidate for a drug carrier in nanomedicine. FNP also displays free radical scavenging activity. DMSO decreased both spontaneous and calcium-induced contractions. In contrast, FNP only decreased spontaneous contraction. FNP decreased copper-zinc superoxide dismutase activity and prevented the DMSO-induced increase in glutathione reductase activity. Atomic force microscopy detected that FNP aggregated with calcium ions. Our results indicate that FNP has properties that make it a good candidate to be a modulator of DMSO activity which could minimize side effects of the latter.
T2  - Journal of Nanoparticle Research
T1  - Fullerenol C-60(OH)(24) nanoparticles decrease relaxing effects of dimethyl sulfoxide on rat uterus spontaneous contraction
VL  - 15
IS  - 5
DO  - 10.1007/s11051-013-1650-1
ER  - 
@article{
author = "Slavic, Marija and Đorđević, Aleksandar N. and Radojicic, Ratko and Milovanović, Slobodan and Oreščanin-Dušić, Zorana S. and Rakočević, Zlatko Lj. and Spasic, Mihajlo B. and Blagojević, Duško P.",
year = "2013",
abstract = "Dimethyl sulfoxide (DMSO) is a widely used solvent and cryoprotectant that can cause impaired blood flow, reduction in intracranial pressure, tissue edema, inflammatory reactions, inhibition of vascular smooth muscle cell migration and proliferation, processes which can lead to atherosclerosis of the coronary, peripheral and cerebral circulation. Although the adverse effects are rare when DMSO is administered in clinically established concentrations, there is no safe antagonist for an overdose. In this work, we treated isolated spontaneous and calcium-induced contractile active rat uteri (Wistar, virgo intacta), with DMSO and fullerenol C-60(OH)(24) nanoparticle (FNP) in DMSO. FNP is a water-soluble derivative of fullerene C-60. Its size is a 1.1 nm in diameter and is a very promising candidate for a drug carrier in nanomedicine. FNP also displays free radical scavenging activity. DMSO decreased both spontaneous and calcium-induced contractions. In contrast, FNP only decreased spontaneous contraction. FNP decreased copper-zinc superoxide dismutase activity and prevented the DMSO-induced increase in glutathione reductase activity. Atomic force microscopy detected that FNP aggregated with calcium ions. Our results indicate that FNP has properties that make it a good candidate to be a modulator of DMSO activity which could minimize side effects of the latter.",
journal = "Journal of Nanoparticle Research",
title = "Fullerenol C-60(OH)(24) nanoparticles decrease relaxing effects of dimethyl sulfoxide on rat uterus spontaneous contraction",
volume = "15",
number = "5",
doi = "10.1007/s11051-013-1650-1"
}
Slavic, M., Đorđević, A. N., Radojicic, R., Milovanović, S., Oreščanin-Dušić, Z. S., Rakočević, Z. Lj., Spasic, M. B.,& Blagojević, D. P.. (2013). Fullerenol C-60(OH)(24) nanoparticles decrease relaxing effects of dimethyl sulfoxide on rat uterus spontaneous contraction. in Journal of Nanoparticle Research, 15(5).
https://doi.org/10.1007/s11051-013-1650-1
Slavic M, Đorđević AN, Radojicic R, Milovanović S, Oreščanin-Dušić ZS, Rakočević ZL, Spasic MB, Blagojević DP. Fullerenol C-60(OH)(24) nanoparticles decrease relaxing effects of dimethyl sulfoxide on rat uterus spontaneous contraction. in Journal of Nanoparticle Research. 2013;15(5).
doi:10.1007/s11051-013-1650-1 .
Slavic, Marija, Đorđević, Aleksandar N., Radojicic, Ratko, Milovanović, Slobodan, Oreščanin-Dušić, Zorana S., Rakočević, Zlatko Lj., Spasic, Mihajlo B., Blagojević, Duško P., "Fullerenol C-60(OH)(24) nanoparticles decrease relaxing effects of dimethyl sulfoxide on rat uterus spontaneous contraction" in Journal of Nanoparticle Research, 15, no. 5 (2013),
https://doi.org/10.1007/s11051-013-1650-1 . .
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15