TY  - JOUR
AU  - Ilić, Radovan D.
AU  - Spasić-Jokić, Vesna
AU  - Beličev, Petar
AU  - Dragovic, M
PY  - 2005
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6497
AB  - This paper describes the application of the SRNA Monte Carlo package for proton transport simulations in complex geometry and different material compositions. The SRNA package was developed for 3D dose distribution calculation in proton therapy and dosimetry and it was based on the theory of multiple scattering. The decay of proton induced compound nuclei was simulated by the Russian MSDM model and our own using ICRU 63 data. The developed package consists of two codes: the SRNA-2KG, which simulates proton transport in combinatorial geometry and the SRNA-VOX, which uses the voxelized geometry using the CT data and conversion of the Hounsfields data to tissue elemental composition. Transition probabilities for both codes are prepared by the SRNADAT code. The simulation of the proton beam characterization by multi-layer Faraday cup, spatial distribution of positron emitters obtained by the SRNA-2KG code and intercomparison of computational codes in radiation dosimetry, indicate immediate application of the Monte Carlo techniques in clinical practice. In this paper, we briefly present the physical model implemented in the SRNA package, the ISTAR proton dose planning software, as well as the results of the numerical experiments with proton beams to obtain 3D dose distribution in the eye and breast tumour.
T2  - Physics in Medicine and Biology
T1  - Monte Carlo SRNA-VOX code for 3D proton dose distribution in voxelized geometry using CT data
VL  - 50
IS  - 5
SP  - 1011
EP  - 1017
DO  - 10.1088/0031-9155/50/5/023
ER  - 

@article{
author = "Ilić, Radovan D. and Spasić-Jokić, Vesna and Beličev, Petar and Dragovic, M",
year = "2005",
abstract = "This paper describes the application of the SRNA Monte Carlo package for proton transport simulations in complex geometry and different material compositions. The SRNA package was developed for 3D dose distribution calculation in proton therapy and dosimetry and it was based on the theory of multiple scattering. The decay of proton induced compound nuclei was simulated by the Russian MSDM model and our own using ICRU 63 data. The developed package consists of two codes: the SRNA-2KG, which simulates proton transport in combinatorial geometry and the SRNA-VOX, which uses the voxelized geometry using the CT data and conversion of the Hounsfields data to tissue elemental composition. Transition probabilities for both codes are prepared by the SRNADAT code. The simulation of the proton beam characterization by multi-layer Faraday cup, spatial distribution of positron emitters obtained by the SRNA-2KG code and intercomparison of computational codes in radiation dosimetry, indicate immediate application of the Monte Carlo techniques in clinical practice. In this paper, we briefly present the physical model implemented in the SRNA package, the ISTAR proton dose planning software, as well as the results of the numerical experiments with proton beams to obtain 3D dose distribution in the eye and breast tumour.",
journal = "Physics in Medicine and Biology",
title = "Monte Carlo SRNA-VOX code for 3D proton dose distribution in voxelized geometry using CT data",
volume = "50",
number = "5",
pages = "1011-1017",
doi = "10.1088/0031-9155/50/5/023"
}

Ilić, R. D., Spasić-Jokić, V., Beličev, P.,& Dragovic, M.. (2005). Monte Carlo SRNA-VOX code for 3D proton dose distribution in voxelized geometry using CT data. in Physics in Medicine and Biology, 50(5), 1011-1017.
https://doi.org/10.1088/0031-9155/50/5/023

Ilić RD, Spasić-Jokić V, Beličev P, Dragovic M. Monte Carlo SRNA-VOX code for 3D proton dose distribution in voxelized geometry using CT data. in Physics in Medicine and Biology. 2005;50(5):1011-1017.
doi:10.1088/0031-9155/50/5/023 .

Ilić, Radovan D., Spasić-Jokić, Vesna, Beličev, Petar, Dragovic, M, "Monte Carlo SRNA-VOX code for 3D proton dose distribution in voxelized geometry using CT data" in Physics in Medicine and Biology, 50, no. 5 (2005):1011-1017,
https://doi.org/10.1088/0031-9155/50/5/023 . .

TY  - JOUR
AU  - Spaic, R
AU  - Ilic, R
AU  - Dragovic, M
AU  - Petrovic, B
PY  - 2005
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6274
AB  - An accurate calculation of the absorbed dose at the cellular level can lead to the optimization of the administered activity and the best clinical response in radionuclide therapy. This paper describes the implementation of dose-volume histograms (DVHs) for dosimetry at the cellular level in radionuclide therapy. The FOTELP code, based on Monte Carlo simulations of photon and electron transport, was used on a three-dimensional multicellular tumor model, which includes tumor morphometry and cell-labeling parameters. Differential and cumulated DVHs were generated for different radionuclides (Cu-67, I-131, Sm-153, Y-90, and Re-188) and labeled cell densities (10, 20, 40, 80, and 100%). DVHs were generated as a percentage of tumor cells in the function of a relative absorbed dose, defined as a cell-absorbed dose divided by an average tumor-absorbed dose. DVHs for high-energy beta emitters, such as Re-188 and Y-90, were very close to the average tumor-absorbed dose. For low-energy beta emitters, such as Cu-67 and I-131, spectra showed that many cells absorbed a much lower dose than the average tumor-absorbed dose. Nonhomogeneity of the radionuclide distribution in tumor, presented by labeled cell density, had a greater influence on DVHs for low-energy beta emitters. Radionuclide therapy plans can be optimized using DVHs.
T2  - Cancer Biotherapy and Radiopharmaceuticals
T1  - Generation of dose-volume histograms using Monte Carlo simulations on a multicellular model in radionuclide therapy
VL  - 20
IS  - 3
SP  - 320
EP  - 324
DO  - 10.1089/cbr.2005.20.320
ER  - 

@article{
author = "Spaic, R and Ilic, R and Dragovic, M and Petrovic, B",
year = "2005",
abstract = "An accurate calculation of the absorbed dose at the cellular level can lead to the optimization of the administered activity and the best clinical response in radionuclide therapy. This paper describes the implementation of dose-volume histograms (DVHs) for dosimetry at the cellular level in radionuclide therapy. The FOTELP code, based on Monte Carlo simulations of photon and electron transport, was used on a three-dimensional multicellular tumor model, which includes tumor morphometry and cell-labeling parameters. Differential and cumulated DVHs were generated for different radionuclides (Cu-67, I-131, Sm-153, Y-90, and Re-188) and labeled cell densities (10, 20, 40, 80, and 100%). DVHs were generated as a percentage of tumor cells in the function of a relative absorbed dose, defined as a cell-absorbed dose divided by an average tumor-absorbed dose. DVHs for high-energy beta emitters, such as Re-188 and Y-90, were very close to the average tumor-absorbed dose. For low-energy beta emitters, such as Cu-67 and I-131, spectra showed that many cells absorbed a much lower dose than the average tumor-absorbed dose. Nonhomogeneity of the radionuclide distribution in tumor, presented by labeled cell density, had a greater influence on DVHs for low-energy beta emitters. Radionuclide therapy plans can be optimized using DVHs.",
journal = "Cancer Biotherapy and Radiopharmaceuticals",
title = "Generation of dose-volume histograms using Monte Carlo simulations on a multicellular model in radionuclide therapy",
volume = "20",
number = "3",
pages = "320-324",
doi = "10.1089/cbr.2005.20.320"
}

Spaic, R., Ilic, R., Dragovic, M.,& Petrovic, B.. (2005). Generation of dose-volume histograms using Monte Carlo simulations on a multicellular model in radionuclide therapy. in Cancer Biotherapy and Radiopharmaceuticals, 20(3), 320-324.
https://doi.org/10.1089/cbr.2005.20.320

Spaic R, Ilic R, Dragovic M, Petrovic B. Generation of dose-volume histograms using Monte Carlo simulations on a multicellular model in radionuclide therapy. in Cancer Biotherapy and Radiopharmaceuticals. 2005;20(3):320-324.
doi:10.1089/cbr.2005.20.320 .

Spaic, R, Ilic, R, Dragovic, M, Petrovic, B, "Generation of dose-volume histograms using Monte Carlo simulations on a multicellular model in radionuclide therapy" in Cancer Biotherapy and Radiopharmaceuticals, 20, no. 3 (2005):320-324,
https://doi.org/10.1089/cbr.2005.20.320 . .

TY  - CONF
AU  - Spaic, R
AU  - Ilic, R
AU  - Dragovic, M
AU  - Petrovic, B
PY  - 2004
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6464
C3  - European Journal of Nuclear Medicine and Molecular Imaging
T1  - Dose volume histograms in radionuclide therapy planning systems at cellular level
VL  - 31
SP  - S475
EP  - S476
UR  - https://hdl.handle.net/21.15107/rcub_vinar_6464
ER  - 

@conference{
author = "Spaic, R and Ilic, R and Dragovic, M and Petrovic, B",
year = "2004",
journal = "European Journal of Nuclear Medicine and Molecular Imaging",
title = "Dose volume histograms in radionuclide therapy planning systems at cellular level",
volume = "31",
pages = "S475-S476",
url = "https://hdl.handle.net/21.15107/rcub_vinar_6464"
}

Spaic, R., Ilic, R., Dragovic, M.,& Petrovic, B.. (2004). Dose volume histograms in radionuclide therapy planning systems at cellular level. in European Journal of Nuclear Medicine and Molecular Imaging, 31, S475-S476.
https://hdl.handle.net/21.15107/rcub_vinar_6464

Spaic R, Ilic R, Dragovic M, Petrovic B. Dose volume histograms in radionuclide therapy planning systems at cellular level. in European Journal of Nuclear Medicine and Molecular Imaging. 2004;31:S475-S476.
https://hdl.handle.net/21.15107/rcub_vinar_6464 .

Spaic, R, Ilic, R, Dragovic, M, Petrovic, B, "Dose volume histograms in radionuclide therapy planning systems at cellular level" in European Journal of Nuclear Medicine and Molecular Imaging, 31 (2004):S475-S476,
https://hdl.handle.net/21.15107/rcub_vinar_6464 .