TY  - JOUR
AU  - Mark, Daniel
AU  - Haeberle, Stefan
AU  - Zengerle, Roland
AU  - Ducree, Jens
AU  - Vladisavljević, Goran T.
PY  - 2009
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3735
AB  - A centrifugally driven pulse-free flow has been used for generation of tripolyphosphate (TPP)-gelated chitosan beads with tunable diameters ranging from 148 to 257 pm. The production process requires a single motor as the sole actively actuated component. The 2% (w/w) chitosan solution was extruded through a polymeric nozzle with an inner diameter of 127 mu m in the centrifugal field ranging from 93 to 452g and the drops were collected in an Eppendorf tube containing 10% (w/w) TPP Solution at pH 4.0. The reproducibility of the bead diameters out of different nozzles was very good with overall CVs of the bead diameters down to 15% and the production rate was 45 beads per second per nozzle at 44 Hz rotor frequency. The production rate was proportional to the sixth power of the rotor frequency, which was explained by the non-Newtonian behaviour of the chitosan solution with a flow behaviour index of 0.466. An analytical model for the bead diameter and production rate has been presented and validated by the experimental data. The shrinkage of chitosan drops during gelation was estimated from the observations and the theoretical model. (C) 2009 Elsevier Inc. All rights reserved
T2  - Journal of Colloid and Interface Science
T1  - Manufacture of chitosan microbeads using centrifugally driven flow of gel-forming solutions through a polymeric micronozzle
VL  - 336
IS  - 2
SP  - 634
EP  - 641
DO  - 10.1016/j.jcis.2009.04.029
ER  - 

@article{
author = "Mark, Daniel and Haeberle, Stefan and Zengerle, Roland and Ducree, Jens and Vladisavljević, Goran T.",
year = "2009",
abstract = "A centrifugally driven pulse-free flow has been used for generation of tripolyphosphate (TPP)-gelated chitosan beads with tunable diameters ranging from 148 to 257 pm. The production process requires a single motor as the sole actively actuated component. The 2% (w/w) chitosan solution was extruded through a polymeric nozzle with an inner diameter of 127 mu m in the centrifugal field ranging from 93 to 452g and the drops were collected in an Eppendorf tube containing 10% (w/w) TPP Solution at pH 4.0. The reproducibility of the bead diameters out of different nozzles was very good with overall CVs of the bead diameters down to 15% and the production rate was 45 beads per second per nozzle at 44 Hz rotor frequency. The production rate was proportional to the sixth power of the rotor frequency, which was explained by the non-Newtonian behaviour of the chitosan solution with a flow behaviour index of 0.466. An analytical model for the bead diameter and production rate has been presented and validated by the experimental data. The shrinkage of chitosan drops during gelation was estimated from the observations and the theoretical model. (C) 2009 Elsevier Inc. All rights reserved",
journal = "Journal of Colloid and Interface Science",
title = "Manufacture of chitosan microbeads using centrifugally driven flow of gel-forming solutions through a polymeric micronozzle",
volume = "336",
number = "2",
pages = "634-641",
doi = "10.1016/j.jcis.2009.04.029"
}

Mark, D., Haeberle, S., Zengerle, R., Ducree, J.,& Vladisavljević, G. T.. (2009). Manufacture of chitosan microbeads using centrifugally driven flow of gel-forming solutions through a polymeric micronozzle. in Journal of Colloid and Interface Science, 336(2), 634-641.
https://doi.org/10.1016/j.jcis.2009.04.029

Mark D, Haeberle S, Zengerle R, Ducree J, Vladisavljević GT. Manufacture of chitosan microbeads using centrifugally driven flow of gel-forming solutions through a polymeric micronozzle. in Journal of Colloid and Interface Science. 2009;336(2):634-641.
doi:10.1016/j.jcis.2009.04.029 .

Mark, Daniel, Haeberle, Stefan, Zengerle, Roland, Ducree, Jens, Vladisavljević, Goran T., "Manufacture of chitosan microbeads using centrifugally driven flow of gel-forming solutions through a polymeric micronozzle" in Journal of Colloid and Interface Science, 336, no. 2 (2009):634-641,
https://doi.org/10.1016/j.jcis.2009.04.029 . .