TY  - JOUR
AU  - Petringa, Giada
AU  - Calvaruso, Marco
AU  - Conte, Valeria
AU  - Bláha, Pavel
AU  - Bravatà, Valentina
AU  - Cammarata, Francesco Paolo
AU  - Cuttone, Giacomo
AU  - Forte, Giusi Irma
AU  - Keta, Otilija D.
AU  - Manti, Lorenzo
AU  - Minafra, Luigi
AU  - Petković, Vladana
AU  - Petrović, Ivan M.
AU  - Richiusa, Selene
AU  - Ristić-Fira, Aleksandra
AU  - Russo, Giorgio
AU  - Cirrone, Giuseppe Antonio Pablo
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9958
AB  - CATANA (Centro di AdroTerapia ed Applicazioni Nucleari Avanzate) was the first Italian protontherapy facility dedicated to the treatment of ocular neoplastic pathologies. It is in operation at the LNS Laboratories of the Italian Institute for Nuclear Physics (INFN-LNS) and to date, 500 patients have been successfully treated. Even though proton therapy has demonstrated success in clinical settings, there is still a need for more accurate models because they are crucial for the estimation of clinically relevant RBE values. Since RBE can vary depending on several physical and biological parameters, there is a clear need for more experimental data to generate predictions. Establishing a database of cell survival experiments is therefore useful to accurately predict the effects of irradiations on both cancerous and normal tissue. The main aim of this work was to compare RBE values obtained from in-vitro experimental data with predictions made by the LEM II (Local Effect Model), Monte Carlo approaches, and semi-empirical models based on LET experimental measurements. For this purpose, the 92.1 uveal melanoma and ARPE-19 cells derived from normal retinal pigmented epithelium were selected and irradiated in the middle of clinical SOBP of the CATANA proton therapy facility. The remarkable results show the potentiality of using microdosimetric spectrum, Monte Carlo simulations and LEM model to predict not only the RBE but also the survival curves.
T2  - Applied Sciences
T1  - Radiobiological Outcomes, Microdosimetric Evaluations and Monte Carlo Predictions in Eye Proton Therapy
VL  - 11
IS  - 19
SP  - 8822
DO  - 10.3390/app11198822
ER  - 

@article{
author = "Petringa, Giada and Calvaruso, Marco and Conte, Valeria and Bláha, Pavel and Bravatà, Valentina and Cammarata, Francesco Paolo and Cuttone, Giacomo and Forte, Giusi Irma and Keta, Otilija D. and Manti, Lorenzo and Minafra, Luigi and Petković, Vladana and Petrović, Ivan M. and Richiusa, Selene and Ristić-Fira, Aleksandra and Russo, Giorgio and Cirrone, Giuseppe Antonio Pablo",
year = "2021",
abstract = "CATANA (Centro di AdroTerapia ed Applicazioni Nucleari Avanzate) was the first Italian protontherapy facility dedicated to the treatment of ocular neoplastic pathologies. It is in operation at the LNS Laboratories of the Italian Institute for Nuclear Physics (INFN-LNS) and to date, 500 patients have been successfully treated. Even though proton therapy has demonstrated success in clinical settings, there is still a need for more accurate models because they are crucial for the estimation of clinically relevant RBE values. Since RBE can vary depending on several physical and biological parameters, there is a clear need for more experimental data to generate predictions. Establishing a database of cell survival experiments is therefore useful to accurately predict the effects of irradiations on both cancerous and normal tissue. The main aim of this work was to compare RBE values obtained from in-vitro experimental data with predictions made by the LEM II (Local Effect Model), Monte Carlo approaches, and semi-empirical models based on LET experimental measurements. For this purpose, the 92.1 uveal melanoma and ARPE-19 cells derived from normal retinal pigmented epithelium were selected and irradiated in the middle of clinical SOBP of the CATANA proton therapy facility. The remarkable results show the potentiality of using microdosimetric spectrum, Monte Carlo simulations and LEM model to predict not only the RBE but also the survival curves.",
journal = "Applied Sciences",
title = "Radiobiological Outcomes, Microdosimetric Evaluations and Monte Carlo Predictions in Eye Proton Therapy",
volume = "11",
number = "19",
pages = "8822",
doi = "10.3390/app11198822"
}

Petringa, G., Calvaruso, M., Conte, V., Bláha, P., Bravatà, V., Cammarata, F. P., Cuttone, G., Forte, G. I., Keta, O. D., Manti, L., Minafra, L., Petković, V., Petrović, I. M., Richiusa, S., Ristić-Fira, A., Russo, G.,& Cirrone, G. A. P.. (2021). Radiobiological Outcomes, Microdosimetric Evaluations and Monte Carlo Predictions in Eye Proton Therapy. in Applied Sciences, 11(19), 8822.
https://doi.org/10.3390/app11198822

Petringa G, Calvaruso M, Conte V, Bláha P, Bravatà V, Cammarata FP, Cuttone G, Forte GI, Keta OD, Manti L, Minafra L, Petković V, Petrović IM, Richiusa S, Ristić-Fira A, Russo G, Cirrone GAP. Radiobiological Outcomes, Microdosimetric Evaluations and Monte Carlo Predictions in Eye Proton Therapy. in Applied Sciences. 2021;11(19):8822.
doi:10.3390/app11198822 .

Petringa, Giada, Calvaruso, Marco, Conte, Valeria, Bláha, Pavel, Bravatà, Valentina, Cammarata, Francesco Paolo, Cuttone, Giacomo, Forte, Giusi Irma, Keta, Otilija D., Manti, Lorenzo, Minafra, Luigi, Petković, Vladana, Petrović, Ivan M., Richiusa, Selene, Ristić-Fira, Aleksandra, Russo, Giorgio, Cirrone, Giuseppe Antonio Pablo, "Radiobiological Outcomes, Microdosimetric Evaluations and Monte Carlo Predictions in Eye Proton Therapy" in Applied Sciences, 11, no. 19 (2021):8822,
https://doi.org/10.3390/app11198822 . .