TY  - JOUR
AU  - Novaković, Slađana B.
AU  - Bogdanović, Goran A.
AU  - Ratković, Zoran
AU  - Blagojević, Stefan
AU  - Matić, Sanja Lj.
AU  - Muškinja, Jovana
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13183
AB  - Two series of new ferrocenyl pyrazolines have been synthesized by the reac-tion of ferrocenyl chalcones and their analogues with hydrazine hydrate in thepresence of corresponding carboxylic acid. Single-crystal X-ray crystallographicdata were used for detailed analysis of the interesting versatility of four com-pounds in the formation of intermolecular interactions. The analysis revealedan excellent structural flexibility of the present ferrocenyl pyrazoline moleculesfor the non-covalent interactions, with a particular contribution of the ferro-cene units. In addition, for comparison with crystallographic findings, weinvestigated the protective effect of all compounds on DNA against hydroxyland peroxyl radicals induced by Fe2+,H2O2, and 2,20-azobis(2-amidinopro-pane) dihydrochloride (AAPH). The results indicated that all compoundsshowed rather similar DNA protective activity, which was comparable withquercetin as a well-known protective compound. This similarity in antigeno-toxic action could be explained by the established excellent structural flexibil-ity of ferrocenyl pyrazolines for the formation of different intermolecularinteractions as important structural property for molecular recognition.
T2  - Applied Organometallic Chemistry
T1  - Synthesis, structural properties and DNA protective activity of ferrocenyl N-acyl pyrazolines
DO  - 10.1002/aoc.7464
ER  - 

@article{
author = "Novaković, Slađana B. and Bogdanović, Goran A. and Ratković, Zoran and Blagojević, Stefan and Matić, Sanja Lj. and Muškinja, Jovana",
year = "2024",
abstract = "Two series of new ferrocenyl pyrazolines have been synthesized by the reac-tion of ferrocenyl chalcones and their analogues with hydrazine hydrate in thepresence of corresponding carboxylic acid. Single-crystal X-ray crystallographicdata were used for detailed analysis of the interesting versatility of four com-pounds in the formation of intermolecular interactions. The analysis revealedan excellent structural flexibility of the present ferrocenyl pyrazoline moleculesfor the non-covalent interactions, with a particular contribution of the ferro-cene units. In addition, for comparison with crystallographic findings, weinvestigated the protective effect of all compounds on DNA against hydroxyland peroxyl radicals induced by Fe2+,H2O2, and 2,20-azobis(2-amidinopro-pane) dihydrochloride (AAPH). The results indicated that all compoundsshowed rather similar DNA protective activity, which was comparable withquercetin as a well-known protective compound. This similarity in antigeno-toxic action could be explained by the established excellent structural flexibil-ity of ferrocenyl pyrazolines for the formation of different intermolecularinteractions as important structural property for molecular recognition.",
journal = "Applied Organometallic Chemistry",
title = "Synthesis, structural properties and DNA protective activity of ferrocenyl N-acyl pyrazolines",
doi = "10.1002/aoc.7464"
}

Novaković, S. B., Bogdanović, G. A., Ratković, Z., Blagojević, S., Matić, S. Lj.,& Muškinja, J.. (2024). Synthesis, structural properties and DNA protective activity of ferrocenyl N-acyl pyrazolines. in Applied Organometallic Chemistry.
https://doi.org/10.1002/aoc.7464

Novaković SB, Bogdanović GA, Ratković Z, Blagojević S, Matić SL, Muškinja J. Synthesis, structural properties and DNA protective activity of ferrocenyl N-acyl pyrazolines. in Applied Organometallic Chemistry. 2024;.
doi:10.1002/aoc.7464 .

Novaković, Slađana B., Bogdanović, Goran A., Ratković, Zoran, Blagojević, Stefan, Matić, Sanja Lj., Muškinja, Jovana, "Synthesis, structural properties and DNA protective activity of ferrocenyl N-acyl pyrazolines" in Applied Organometallic Chemistry (2024),
https://doi.org/10.1002/aoc.7464 . .