TY  - JOUR
AU  - Tomić, Aleksandra
AU  - Zafirović, Sonja
AU  - Gluvić, Zoran
AU  - Samardžić, Vladimir
AU  - Mačvanin, Mirjana
AU  - Radunović, Maja
AU  - Isenović, Esma R.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11875
AB  - Background:Subacute thyroiditis (SAT) is an organ-specific disease that various drugs, including COVID-19vaccines, can trigger. COVID-19 infection has been associated with thyroid gland damage and disease SARS-CoV-2direct action, euthyroid sick syndrome, and immune-mediated mechanisms are all potential mechanisms of thyroiddamage. It denotes thyroid gland inflammation, most commonly of viral origin, and belongs to the transitory, self-limiting thyroid gland diseases group, causing complications in approximately 15% of patients in the formof permanent hypothyroidism. Some authors say SAT is the most common thyroid disease associated withCOVID-19.Purpose:The occurrence of SAT many weeks after administering the second COVID-19 vaccine is rare and has limiteddocumentation in academic literature. This study aims to present the occurrence of SAT after administering the COVID-19vaccine. We present the case of a 37-year-old man who developed SAT 23 days after receiving the second dose of PfizerBioNTech’s COVID-19 mRNA vaccine.Research design and study sample:Due to neck pain and an elevated body temperature (up to 38.2°C), a 37-year-old male subject presented for examination 23 days after receiving the second Pfizer BioNTech mRNA vaccineagainst SARS-CoV-2 viral infection. The patient deniedever having an autoimmune disease or any other disease.Painful neck palpation and afirm, slightly enlarged thyroid gland with no surrounding lymphadenopathy wereidentified during the exam. The heart rate was 104 beatsper minute. All of the remaining physicalfindings werenormal.Data collection and/or Analysis:Data collected during the disease are integral to the medical record.Results:Hematology and biochemistry analyses at the initial and follow-up visits revealed minor leukocytosis, normocyticanaemia, and thrombocytosis, followed by a mild increase in lactate dehydrogenase and decreased iron levels. The patient’sthyroid function and morphology had recovered entirely from post-vaccine SAT.Conclusions: Results from this study emphasise the need for healthcare professionals to promptly report any case of SATrelated to COVID-19 vaccination. Further investigation is warranted to understand the immunopathogenesis of COVID-19-associated thyroiditis and the impact of COVID-19 immunization on this condition.
T2  - Antiviral Therapy
T1  - Subacute thyroiditis following COVID-19 vaccination: Case presentation
VL  - 28
IS  - 5
DO  - 10.1177/13596535231208831
ER  - 

@article{
author = "Tomić, Aleksandra and Zafirović, Sonja and Gluvić, Zoran and Samardžić, Vladimir and Mačvanin, Mirjana and Radunović, Maja and Isenović, Esma R.",
year = "2023",
abstract = "Background:Subacute thyroiditis (SAT) is an organ-specific disease that various drugs, including COVID-19vaccines, can trigger. COVID-19 infection has been associated with thyroid gland damage and disease SARS-CoV-2direct action, euthyroid sick syndrome, and immune-mediated mechanisms are all potential mechanisms of thyroiddamage. It denotes thyroid gland inflammation, most commonly of viral origin, and belongs to the transitory, self-limiting thyroid gland diseases group, causing complications in approximately 15% of patients in the formof permanent hypothyroidism. Some authors say SAT is the most common thyroid disease associated withCOVID-19.Purpose:The occurrence of SAT many weeks after administering the second COVID-19 vaccine is rare and has limiteddocumentation in academic literature. This study aims to present the occurrence of SAT after administering the COVID-19vaccine. We present the case of a 37-year-old man who developed SAT 23 days after receiving the second dose of PfizerBioNTech’s COVID-19 mRNA vaccine.Research design and study sample:Due to neck pain and an elevated body temperature (up to 38.2°C), a 37-year-old male subject presented for examination 23 days after receiving the second Pfizer BioNTech mRNA vaccineagainst SARS-CoV-2 viral infection. The patient deniedever having an autoimmune disease or any other disease.Painful neck palpation and afirm, slightly enlarged thyroid gland with no surrounding lymphadenopathy wereidentified during the exam. The heart rate was 104 beatsper minute. All of the remaining physicalfindings werenormal.Data collection and/or Analysis:Data collected during the disease are integral to the medical record.Results:Hematology and biochemistry analyses at the initial and follow-up visits revealed minor leukocytosis, normocyticanaemia, and thrombocytosis, followed by a mild increase in lactate dehydrogenase and decreased iron levels. The patient’sthyroid function and morphology had recovered entirely from post-vaccine SAT.Conclusions: Results from this study emphasise the need for healthcare professionals to promptly report any case of SATrelated to COVID-19 vaccination. Further investigation is warranted to understand the immunopathogenesis of COVID-19-associated thyroiditis and the impact of COVID-19 immunization on this condition.",
journal = "Antiviral Therapy",
title = "Subacute thyroiditis following COVID-19 vaccination: Case presentation",
volume = "28",
number = "5",
doi = "10.1177/13596535231208831"
}

Tomić, A., Zafirović, S., Gluvić, Z., Samardžić, V., Mačvanin, M., Radunović, M.,& Isenović, E. R.. (2023). Subacute thyroiditis following COVID-19 vaccination: Case presentation. in Antiviral Therapy, 28(5).
https://doi.org/10.1177/13596535231208831

Tomić A, Zafirović S, Gluvić Z, Samardžić V, Mačvanin M, Radunović M, Isenović ER. Subacute thyroiditis following COVID-19 vaccination: Case presentation. in Antiviral Therapy. 2023;28(5).
doi:10.1177/13596535231208831 .

Tomić, Aleksandra, Zafirović, Sonja, Gluvić, Zoran, Samardžić, Vladimir, Mačvanin, Mirjana, Radunović, Maja, Isenović, Esma R., "Subacute thyroiditis following COVID-19 vaccination: Case presentation" in Antiviral Therapy, 28, no. 5 (2023),
https://doi.org/10.1177/13596535231208831 . .

TY  - CONF
AU  - Tomasović, Martina
AU  - Sinik, Marija
AU  - Joksimović, Bojan
AU  - Lacković, Milena
AU  - Samardžić, Vladimir
AU  - Vujović, Marina
AU  - Gluvić, Zoran
AU  - Obradović, Milan
AU  - Zafirović, Sonja
AU  - Isenović, Esma R.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12029
AB  - Propylthiouracil (PTU) sometimes induces autoimmune syndromes, such as PTU–induced lupus or vasculitis. Here we present hands and feet vasculitis-like skin changes observed several days after PTU introduction in a patient who suffered from serious diffuse toxic goiter. Because of segmental distribution, normal liver function test, and no signs of clinical deterioration, it was decided to continue PTU management and observe the patient. Primarily maculopapular rash became vesicular shortly after and then scaly. After two weeks, skin changes were entirely restored with no scaring. Taking into account thorough epidemiological survey, clinical course, and performed diagnostics, presented skin changes were diagnosed as Hand, Foot, and Mouth disease (HFMD). Clinicians must be aware of the side effects of used drugs, especially after their introduction. Some clinical presentations could only resemble expected or well-known side-effects, intolerance, or hypersensitivity to the used drug. Every clinical presentation associated with any drug introduction must be thoroughly evaluated. The presented case revealed that skin changes of HFMD mimicked PTU-induced vasculitis.
C3  - Endocrine Abstracts
T1  - Hand and foot skin changes resembling PTU-induced vasculitis in a young male with diffuse toxic goiter- a case report
DO  - 10.1530/endoabs.81.EP1030
ER  - 

@conference{
author = "Tomasović, Martina and Sinik, Marija and Joksimović, Bojan and Lacković, Milena and Samardžić, Vladimir and Vujović, Marina and Gluvić, Zoran and Obradović, Milan and Zafirović, Sonja and Isenović, Esma R.",
year = "2022",
abstract = "Propylthiouracil (PTU) sometimes induces autoimmune syndromes, such as PTU–induced lupus or vasculitis. Here we present hands and feet vasculitis-like skin changes observed several days after PTU introduction in a patient who suffered from serious diffuse toxic goiter. Because of segmental distribution, normal liver function test, and no signs of clinical deterioration, it was decided to continue PTU management and observe the patient. Primarily maculopapular rash became vesicular shortly after and then scaly. After two weeks, skin changes were entirely restored with no scaring. Taking into account thorough epidemiological survey, clinical course, and performed diagnostics, presented skin changes were diagnosed as Hand, Foot, and Mouth disease (HFMD). Clinicians must be aware of the side effects of used drugs, especially after their introduction. Some clinical presentations could only resemble expected or well-known side-effects, intolerance, or hypersensitivity to the used drug. Every clinical presentation associated with any drug introduction must be thoroughly evaluated. The presented case revealed that skin changes of HFMD mimicked PTU-induced vasculitis.",
journal = "Endocrine Abstracts",
title = "Hand and foot skin changes resembling PTU-induced vasculitis in a young male with diffuse toxic goiter- a case report",
doi = "10.1530/endoabs.81.EP1030"
}

Tomasović, M., Sinik, M., Joksimović, B., Lacković, M., Samardžić, V., Vujović, M., Gluvić, Z., Obradović, M., Zafirović, S.,& Isenović, E. R.. (2022). Hand and foot skin changes resembling PTU-induced vasculitis in a young male with diffuse toxic goiter- a case report. in Endocrine Abstracts.
https://doi.org/10.1530/endoabs.81.EP1030

Tomasović M, Sinik M, Joksimović B, Lacković M, Samardžić V, Vujović M, Gluvić Z, Obradović M, Zafirović S, Isenović ER. Hand and foot skin changes resembling PTU-induced vasculitis in a young male with diffuse toxic goiter- a case report. in Endocrine Abstracts. 2022;.
doi:10.1530/endoabs.81.EP1030 .

Tomasović, Martina, Sinik, Marija, Joksimović, Bojan, Lacković, Milena, Samardžić, Vladimir, Vujović, Marina, Gluvić, Zoran, Obradović, Milan, Zafirović, Sonja, Isenović, Esma R., "Hand and foot skin changes resembling PTU-induced vasculitis in a young male with diffuse toxic goiter- a case report" in Endocrine Abstracts (2022),
https://doi.org/10.1530/endoabs.81.EP1030 . .

TY  - CONF
AU  - Tomasović, M.
AU  - Šinik, M.
AU  - Joksimović, Bojan
AU  - Lačković, M.
AU  - Samardžić, Vladimir
AU  - Gluvić, Zoran
AU  - Vujović, M.
AU  - Zafirović, Sonja
AU  - Mačvanin, Mirjana
AU  - Isenović, Esma R.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12034
AB  - Uvod i cilj. Hipotiroza je često endokrinološko oboljenje, sa širokim spektrom kliničke prezentacije: od asimptomatske do multiorganske, koja prognostički može biti ozbiljna. Atipične prezentacije hipotiroze retko mogu biti i inicijalne, poput perikardnog izliva (PI). Prikazujemo bolesnika sa novodijagnostikovanom primarnom hipotirozom, prezentovanom simptomima i znacima srčane insuficijencije, sa ehokardiografski detektovanim PI. Metode. Bolesnik je obrađen klinički, elektrokardiografski, laboratorijski i ultrasonografski (štitasta žlezda i srce). Rezultati. Muškarac star 47 godina se javlja u hitnu internističku ambulantu zbog otoka nogu, lica i zamaranja, trajanja oko godinu dana. Anamnestički bez poznatih komorbiditeta. Objektivno se kod hipometaboličnog bolesnika sa JVP 1+, bez prisustva Bekove trijade, detektuju pretibijalni edemi, bez drugog patološkog nalaza po sistemima. TA 110/70 mmHg, P 56/min. EKG: sinusni ritam, frekvence oko 55/min, niže voltaže, bez ST i T promena. U laboratorijskim analizama beleže se blaga normocitna anemija, HLP 2b i povišene vrednosti CK i transaminaza. TFT ukazuju na autoimunsku primarnu hipotirozu (TSH 35, FT4 <1.93, Anti TPO 234). Ehokardiografski nalaz ukazuje na cirkularni PI, bez znakova preteće tamponade, dok ultrazvuk štitaste žlezde odgovara hroničnom tiroiditisu. Vrednosti tumorskih i sistemskih autoimunskih markera su bez odstupanja. Započinje se postepenom supstitucijom levotiroksinom. Kontrolna ehokardiografska studija (pet nedelja nakon inicijalne) ukazuje na smanjenje PI, dok se laboratorijski registruje pad nivoa TSH (6.35). Zaključak. PI je retka inicijalna prezentacija hipotiroze, koja ako se prepozna blagovremeno, sprečava razvoj ozbiljnog kardiovaskularnog morbiditeta. Potrebno je, posebno kod mlađih bolesnika, razmotriti postojanje pridruženih uzroka PI (SBVT, maligne i infektivne bolesti), koji se klinički mogu prezentovati mitigirano.
C3  - KES2022 : 8. Kongres endokrinologa Srbije sa međunarodnim učešćem : Program i zbornik sažetaka
T1  - Perikardni izliv kao inicijalna prezentacija novodijagnostikovane primarne hipotiroze – prikaz slučaja
SP  - 134
EP  - 134
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12034
ER  - 

@conference{
author = "Tomasović, M. and Šinik, M. and Joksimović, Bojan and Lačković, M. and Samardžić, Vladimir and Gluvić, Zoran and Vujović, M. and Zafirović, Sonja and Mačvanin, Mirjana and Isenović, Esma R.",
year = "2022",
abstract = "Uvod i cilj. Hipotiroza je često endokrinološko oboljenje, sa širokim spektrom kliničke prezentacije: od asimptomatske do multiorganske, koja prognostički može biti ozbiljna. Atipične prezentacije hipotiroze retko mogu biti i inicijalne, poput perikardnog izliva (PI). Prikazujemo bolesnika sa novodijagnostikovanom primarnom hipotirozom, prezentovanom simptomima i znacima srčane insuficijencije, sa ehokardiografski detektovanim PI. Metode. Bolesnik je obrađen klinički, elektrokardiografski, laboratorijski i ultrasonografski (štitasta žlezda i srce). Rezultati. Muškarac star 47 godina se javlja u hitnu internističku ambulantu zbog otoka nogu, lica i zamaranja, trajanja oko godinu dana. Anamnestički bez poznatih komorbiditeta. Objektivno se kod hipometaboličnog bolesnika sa JVP 1+, bez prisustva Bekove trijade, detektuju pretibijalni edemi, bez drugog patološkog nalaza po sistemima. TA 110/70 mmHg, P 56/min. EKG: sinusni ritam, frekvence oko 55/min, niže voltaže, bez ST i T promena. U laboratorijskim analizama beleže se blaga normocitna anemija, HLP 2b i povišene vrednosti CK i transaminaza. TFT ukazuju na autoimunsku primarnu hipotirozu (TSH 35, FT4 <1.93, Anti TPO 234). Ehokardiografski nalaz ukazuje na cirkularni PI, bez znakova preteće tamponade, dok ultrazvuk štitaste žlezde odgovara hroničnom tiroiditisu. Vrednosti tumorskih i sistemskih autoimunskih markera su bez odstupanja. Započinje se postepenom supstitucijom levotiroksinom. Kontrolna ehokardiografska studija (pet nedelja nakon inicijalne) ukazuje na smanjenje PI, dok se laboratorijski registruje pad nivoa TSH (6.35). Zaključak. PI je retka inicijalna prezentacija hipotiroze, koja ako se prepozna blagovremeno, sprečava razvoj ozbiljnog kardiovaskularnog morbiditeta. Potrebno je, posebno kod mlađih bolesnika, razmotriti postojanje pridruženih uzroka PI (SBVT, maligne i infektivne bolesti), koji se klinički mogu prezentovati mitigirano.",
journal = "KES2022 : 8. Kongres endokrinologa Srbije sa međunarodnim učešćem : Program i zbornik sažetaka",
title = "Perikardni izliv kao inicijalna prezentacija novodijagnostikovane primarne hipotiroze – prikaz slučaja",
pages = "134-134",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12034"
}

Tomasović, M., Šinik, M., Joksimović, B., Lačković, M., Samardžić, V., Gluvić, Z., Vujović, M., Zafirović, S., Mačvanin, M.,& Isenović, E. R.. (2022). Perikardni izliv kao inicijalna prezentacija novodijagnostikovane primarne hipotiroze – prikaz slučaja. in KES2022 : 8. Kongres endokrinologa Srbije sa međunarodnim učešćem : Program i zbornik sažetaka, 134-134.
https://hdl.handle.net/21.15107/rcub_vinar_12034

Tomasović M, Šinik M, Joksimović B, Lačković M, Samardžić V, Gluvić Z, Vujović M, Zafirović S, Mačvanin M, Isenović ER. Perikardni izliv kao inicijalna prezentacija novodijagnostikovane primarne hipotiroze – prikaz slučaja. in KES2022 : 8. Kongres endokrinologa Srbije sa međunarodnim učešćem : Program i zbornik sažetaka. 2022;:134-134.
https://hdl.handle.net/21.15107/rcub_vinar_12034 .

Tomasović, M., Šinik, M., Joksimović, Bojan, Lačković, M., Samardžić, Vladimir, Gluvić, Zoran, Vujović, M., Zafirović, Sonja, Mačvanin, Mirjana, Isenović, Esma R., "Perikardni izliv kao inicijalna prezentacija novodijagnostikovane primarne hipotiroze – prikaz slučaja" in KES2022 : 8. Kongres endokrinologa Srbije sa međunarodnim učešćem : Program i zbornik sažetaka (2022):134-134,
https://hdl.handle.net/21.15107/rcub_vinar_12034 .

TY  - CONF
AU  - Gluvić, Zoran
AU  - Lačković, Milena
AU  - Samardžić, Vladimir
AU  - Tomašević, Ratko
AU  - Pavlović, Aleksandar
AU  - Obradović, Milan
AU  - Zafirović, Sonja
AU  - Mladenović, Violeta
AU  - Radenković, Saša
AU  - Isenović, Esma R.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12035
C3  - 4. Srpski kongres o menopauzi i involutivnom hipoandrogenizmu : Knjiga apstrakata
T1  - Nealkoholna masna bolest jetre: klinički multidisciplinarni pristup- institucionalna adaptacija postojećim Vodičima kliničke prakse
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12035
ER  - 

@conference{
author = "Gluvić, Zoran and Lačković, Milena and Samardžić, Vladimir and Tomašević, Ratko and Pavlović, Aleksandar and Obradović, Milan and Zafirović, Sonja and Mladenović, Violeta and Radenković, Saša and Isenović, Esma R.",
year = "2022",
journal = "4. Srpski kongres o menopauzi i involutivnom hipoandrogenizmu : Knjiga apstrakata",
title = "Nealkoholna masna bolest jetre: klinički multidisciplinarni pristup- institucionalna adaptacija postojećim Vodičima kliničke prakse",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12035"
}

Gluvić, Z., Lačković, M., Samardžić, V., Tomašević, R., Pavlović, A., Obradović, M., Zafirović, S., Mladenović, V., Radenković, S.,& Isenović, E. R.. (2022). Nealkoholna masna bolest jetre: klinički multidisciplinarni pristup- institucionalna adaptacija postojećim Vodičima kliničke prakse. in 4. Srpski kongres o menopauzi i involutivnom hipoandrogenizmu : Knjiga apstrakata.
https://hdl.handle.net/21.15107/rcub_vinar_12035

Gluvić Z, Lačković M, Samardžić V, Tomašević R, Pavlović A, Obradović M, Zafirović S, Mladenović V, Radenković S, Isenović ER. Nealkoholna masna bolest jetre: klinički multidisciplinarni pristup- institucionalna adaptacija postojećim Vodičima kliničke prakse. in 4. Srpski kongres o menopauzi i involutivnom hipoandrogenizmu : Knjiga apstrakata. 2022;.
https://hdl.handle.net/21.15107/rcub_vinar_12035 .

Gluvić, Zoran, Lačković, Milena, Samardžić, Vladimir, Tomašević, Ratko, Pavlović, Aleksandar, Obradović, Milan, Zafirović, Sonja, Mladenović, Violeta, Radenković, Saša, Isenović, Esma R., "Nealkoholna masna bolest jetre: klinički multidisciplinarni pristup- institucionalna adaptacija postojećim Vodičima kliničke prakse" in 4. Srpski kongres o menopauzi i involutivnom hipoandrogenizmu : Knjiga apstrakata (2022),
https://hdl.handle.net/21.15107/rcub_vinar_12035 .

TY  - CONF
AU  - Samardžić, Vladimir
AU  - Lačković, Milena
AU  - Joksimović, Bojan
AU  - Šinik, M.
AU  - Miladinović, M.
AU  - Zorić, G.
AU  - Obradović, Milan
AU  - Zafirović, Sonja
AU  - Isenović, Esma R.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12036
AB  - Definisanje malignog potencijala tiroidnih nodusa (TN) je najznačajnija odrednica u njihovoj evaluaciji. Primena imidžing metoda, kao i biohemijskih, citoloških i molekularno bioloških alata doprinosi razlikovanju benignih od malignih TN i tako delimično smanjuje broj nepotrebno tiroidektomsanih pacijenata. Jasno je da idealni biomarker ili metoda za definisanje prirode TN ne postoji, ali smo svedoci nastojanja kliničara da detektuju biomarker ili biomarkere koji bi samostalno ili u kombinaciji sa drugim alatima omogućili još kvalitetniju regrutaciju ispitanika kojima je tiroidektomija zaista potrebna. Studija Samardžića i aut. je analizirala biomarkere u ispirku bioptata TN i pokazala da nivo tiroglobulina u ispirku (TGw) pozitivno koreliše sa Bethesda kategorijom citološkog nalaza bioptata TN, dok nivo NOw pozitivno koreliše sa EU-TIRADS kategorijama. Tako se kod četvoro od petoro tiroidektomisanih ispitanika registrovala pripadnost EU-TIRADS kategorijama 4 i 5. Potencijal NOw i TGw kao pomoćnog alata za preciziranje prirode TN je nedvosmislen, te u budućim kliničkim studijama treba analizirati njihovu pojedinačnu i pridruženu prediktivnost u definisanju malignih TN na većoj populaciji ispitanika.
PB  - Beograd : Srpsko Tiroidno Društvo
C3  - 7. Srpski kongres o štitastoj žlezdi : Finalni program i Zbornik sažetaka
T1  - Azot-monoksid- biomarker u dijagnostici tiroidnih nodusa
SP  - 19
EP  - 19
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12036
ER  - 

@conference{
author = "Samardžić, Vladimir and Lačković, Milena and Joksimović, Bojan and Šinik, M. and Miladinović, M. and Zorić, G. and Obradović, Milan and Zafirović, Sonja and Isenović, Esma R.",
year = "2022",
abstract = "Definisanje malignog potencijala tiroidnih nodusa (TN) je najznačajnija odrednica u njihovoj evaluaciji. Primena imidžing metoda, kao i biohemijskih, citoloških i molekularno bioloških alata doprinosi razlikovanju benignih od malignih TN i tako delimično smanjuje broj nepotrebno tiroidektomsanih pacijenata. Jasno je da idealni biomarker ili metoda za definisanje prirode TN ne postoji, ali smo svedoci nastojanja kliničara da detektuju biomarker ili biomarkere koji bi samostalno ili u kombinaciji sa drugim alatima omogućili još kvalitetniju regrutaciju ispitanika kojima je tiroidektomija zaista potrebna. Studija Samardžića i aut. je analizirala biomarkere u ispirku bioptata TN i pokazala da nivo tiroglobulina u ispirku (TGw) pozitivno koreliše sa Bethesda kategorijom citološkog nalaza bioptata TN, dok nivo NOw pozitivno koreliše sa EU-TIRADS kategorijama. Tako se kod četvoro od petoro tiroidektomisanih ispitanika registrovala pripadnost EU-TIRADS kategorijama 4 i 5. Potencijal NOw i TGw kao pomoćnog alata za preciziranje prirode TN je nedvosmislen, te u budućim kliničkim studijama treba analizirati njihovu pojedinačnu i pridruženu prediktivnost u definisanju malignih TN na većoj populaciji ispitanika.",
publisher = "Beograd : Srpsko Tiroidno Društvo",
journal = "7. Srpski kongres o štitastoj žlezdi : Finalni program i Zbornik sažetaka",
title = "Azot-monoksid- biomarker u dijagnostici tiroidnih nodusa",
pages = "19-19",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12036"
}

Samardžić, V., Lačković, M., Joksimović, B., Šinik, M., Miladinović, M., Zorić, G., Obradović, M., Zafirović, S.,& Isenović, E. R.. (2022). Azot-monoksid- biomarker u dijagnostici tiroidnih nodusa. in 7. Srpski kongres o štitastoj žlezdi : Finalni program i Zbornik sažetaka
Beograd : Srpsko Tiroidno Društvo., 19-19.
https://hdl.handle.net/21.15107/rcub_vinar_12036

Samardžić V, Lačković M, Joksimović B, Šinik M, Miladinović M, Zorić G, Obradović M, Zafirović S, Isenović ER. Azot-monoksid- biomarker u dijagnostici tiroidnih nodusa. in 7. Srpski kongres o štitastoj žlezdi : Finalni program i Zbornik sažetaka. 2022;:19-19.
https://hdl.handle.net/21.15107/rcub_vinar_12036 .

Samardžić, Vladimir, Lačković, Milena, Joksimović, Bojan, Šinik, M., Miladinović, M., Zorić, G., Obradović, Milan, Zafirović, Sonja, Isenović, Esma R., "Azot-monoksid- biomarker u dijagnostici tiroidnih nodusa" in 7. Srpski kongres o štitastoj žlezdi : Finalni program i Zbornik sažetaka (2022):19-19,
https://hdl.handle.net/21.15107/rcub_vinar_12036 .

TY  - JOUR
AU  - Gluvić, Zoran
AU  - Obradović, Milan M.
AU  - Stewart, Alan J.
AU  - Essack, Magbubah
AU  - Pitt, Samantha J.
AU  - Samardžić, Vladimir
AU  - Soskić, Sanja S.
AU  - Gojobori, Takashi
AU  - Isenović, Esma R.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10047
AB  - Levothyroxine (LT4) is used to treat frequently encountered endocrinopathies such as thyroid diseases. It is regularly used in clinical (overt) hypothyroidism cases and subclinical (latent) hypothyroidism cases in the last decade. Suppressive LT4 therapy is also part of the medical regimen used to manage thyroid malignancies after a thyroidectomy. LT4 treatment possesses dual effects: substituting new-onset thyroid hormone deficiency and suppressing the local and distant malignancy spreading in cancer. It is the practice to administer LT4 in less-than-high suppressive doses for growth control of thyroid nodules and goiter, even in patients with preserved thyroid function. Despite its approved safety for clinical use, LT4 can sometimes induce side-effects, more often recorded with patients under treatment with LT4 suppressive doses than in unintentionally LT4-overdosed patients. Cardiac arrhythmias and the deterioration of osteoporosis are the most frequently documented side-effects of LT4 therapy. It also lowers the threshold for the onset or aggravation of cardiac arrhythmias for patients with pre-existing heart diseases. To improve the quality of life in LT4-substituted patients, clinicians often prescribe higher doses of LT4 to reach low normal TSH levels to achieve cellular euthyroidism. In such circumstances, the risk of cardiac arrhythmias, particularly atrial fibrillation, increases, and the combined use of LT4 and triiodothyronine further complicates such risk. This review summarizes the relevant available data related to LT4 suppressive treatment and the associated risk of cardiac arrhythmia.
T2  - Frontiers in Endocrinology
T1  - Levothyroxine Treatment and the Risk of Cardiac Arrhythmias – Focus on the Patient Submitted to Thyroid Surgery
VL  - 12
SP  - 1415
DO  - 10.3389/fendo.2021.758043
ER  - 

@article{
author = "Gluvić, Zoran and Obradović, Milan M. and Stewart, Alan J. and Essack, Magbubah and Pitt, Samantha J. and Samardžić, Vladimir and Soskić, Sanja S. and Gojobori, Takashi and Isenović, Esma R.",
year = "2021",
abstract = "Levothyroxine (LT4) is used to treat frequently encountered endocrinopathies such as thyroid diseases. It is regularly used in clinical (overt) hypothyroidism cases and subclinical (latent) hypothyroidism cases in the last decade. Suppressive LT4 therapy is also part of the medical regimen used to manage thyroid malignancies after a thyroidectomy. LT4 treatment possesses dual effects: substituting new-onset thyroid hormone deficiency and suppressing the local and distant malignancy spreading in cancer. It is the practice to administer LT4 in less-than-high suppressive doses for growth control of thyroid nodules and goiter, even in patients with preserved thyroid function. Despite its approved safety for clinical use, LT4 can sometimes induce side-effects, more often recorded with patients under treatment with LT4 suppressive doses than in unintentionally LT4-overdosed patients. Cardiac arrhythmias and the deterioration of osteoporosis are the most frequently documented side-effects of LT4 therapy. It also lowers the threshold for the onset or aggravation of cardiac arrhythmias for patients with pre-existing heart diseases. To improve the quality of life in LT4-substituted patients, clinicians often prescribe higher doses of LT4 to reach low normal TSH levels to achieve cellular euthyroidism. In such circumstances, the risk of cardiac arrhythmias, particularly atrial fibrillation, increases, and the combined use of LT4 and triiodothyronine further complicates such risk. This review summarizes the relevant available data related to LT4 suppressive treatment and the associated risk of cardiac arrhythmia.",
journal = "Frontiers in Endocrinology",
title = "Levothyroxine Treatment and the Risk of Cardiac Arrhythmias – Focus on the Patient Submitted to Thyroid Surgery",
volume = "12",
pages = "1415",
doi = "10.3389/fendo.2021.758043"
}

Gluvić, Z., Obradović, M. M., Stewart, A. J., Essack, M., Pitt, S. J., Samardžić, V., Soskić, S. S., Gojobori, T.,& Isenović, E. R.. (2021). Levothyroxine Treatment and the Risk of Cardiac Arrhythmias – Focus on the Patient Submitted to Thyroid Surgery. in Frontiers in Endocrinology, 12, 1415.
https://doi.org/10.3389/fendo.2021.758043

Gluvić Z, Obradović MM, Stewart AJ, Essack M, Pitt SJ, Samardžić V, Soskić SS, Gojobori T, Isenović ER. Levothyroxine Treatment and the Risk of Cardiac Arrhythmias – Focus on the Patient Submitted to Thyroid Surgery. in Frontiers in Endocrinology. 2021;12:1415.
doi:10.3389/fendo.2021.758043 .

Gluvić, Zoran, Obradović, Milan M., Stewart, Alan J., Essack, Magbubah, Pitt, Samantha J., Samardžić, Vladimir, Soskić, Sanja S., Gojobori, Takashi, Isenović, Esma R., "Levothyroxine Treatment and the Risk of Cardiac Arrhythmias – Focus on the Patient Submitted to Thyroid Surgery" in Frontiers in Endocrinology, 12 (2021):1415,
https://doi.org/10.3389/fendo.2021.758043 . .

TY  - CONF
AU  - Mitrović, Bojan
AU  - Samardžić, Vladimir
AU  - Gluvić, Zoran
AU  - Tomasević, Ratko
AU  - Obradović, Milan
AU  - Sudar-Milovanović, Emina
AU  - Isenović, Esma R.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12030
AB  - Introduction  Non-alcoholic fatty liver disease (NAFLD) is a component of metabolic syndrome (MetS). Hence, it is frequently associated with type 2 diabetes mellitus (T2DM). The low-grade inflammation associated with NAFLD usually explained the changes in serum iron metabolism. This study aims to assess the link between liver steatosis severity and serum iron, ferritin, and transferrin levels.  Material and methods  A case-control study involved 30 non-obese subjects (BMI 18.5–30 kg/m2), who suffered from T2DM for less than 5 years. Such subjects are regularly under treatment by metformin (M) and sulphonylurea (SU) derivates. Liver steatosis severity is determined by ultrasonography and presented as grades 1, 2, and 3 (initial, moderate, and advanced liver steatosis), respectively, according to Singh et al. criteria (Singh et al. Indian J Endocr Metab 2013;17: 990–5).  Results  In the observed population, 14 (47%), 11 (36%), and 5 (17%) subjects are determined to grade 1, 2, and 3 liver steatosis severity groups, respectively. The mean values of iron homeostasis markers have not differed from normal values. Liver steatosis severity grades positively correlated with serum ferritin levels, and this correlation is not revealed in the cases with serum iron and transferrin levels.  Conclusion  The low grade of liver steatosis has predominated in non-obese T2DM subjects under treatment with M and SU, irrespective of glycemic control quality. An increase in liver steatosis severity follows the ascending trend of ferritin levels. Further studies are needed to elucidate the impact of the quality of T2DM control on liver steatosis severity and iron metabolism markers.
C3  - Endocrine Abstracts
T1  - Serum ferritin levels correlate with ultrasonography-determined liver steatosis severity in type 2 diabetes patients with NAFLD
DO  - 10.1530/endoabs.73.AEP294
ER  - 

@conference{
author = "Mitrović, Bojan and Samardžić, Vladimir and Gluvić, Zoran and Tomasević, Ratko and Obradović, Milan and Sudar-Milovanović, Emina and Isenović, Esma R.",
year = "2021",
abstract = "Introduction  Non-alcoholic fatty liver disease (NAFLD) is a component of metabolic syndrome (MetS). Hence, it is frequently associated with type 2 diabetes mellitus (T2DM). The low-grade inflammation associated with NAFLD usually explained the changes in serum iron metabolism. This study aims to assess the link between liver steatosis severity and serum iron, ferritin, and transferrin levels.  Material and methods  A case-control study involved 30 non-obese subjects (BMI 18.5–30 kg/m2), who suffered from T2DM for less than 5 years. Such subjects are regularly under treatment by metformin (M) and sulphonylurea (SU) derivates. Liver steatosis severity is determined by ultrasonography and presented as grades 1, 2, and 3 (initial, moderate, and advanced liver steatosis), respectively, according to Singh et al. criteria (Singh et al. Indian J Endocr Metab 2013;17: 990–5).  Results  In the observed population, 14 (47%), 11 (36%), and 5 (17%) subjects are determined to grade 1, 2, and 3 liver steatosis severity groups, respectively. The mean values of iron homeostasis markers have not differed from normal values. Liver steatosis severity grades positively correlated with serum ferritin levels, and this correlation is not revealed in the cases with serum iron and transferrin levels.  Conclusion  The low grade of liver steatosis has predominated in non-obese T2DM subjects under treatment with M and SU, irrespective of glycemic control quality. An increase in liver steatosis severity follows the ascending trend of ferritin levels. Further studies are needed to elucidate the impact of the quality of T2DM control on liver steatosis severity and iron metabolism markers.",
journal = "Endocrine Abstracts",
title = "Serum ferritin levels correlate with ultrasonography-determined liver steatosis severity in type 2 diabetes patients with NAFLD",
doi = "10.1530/endoabs.73.AEP294"
}

Mitrović, B., Samardžić, V., Gluvić, Z., Tomasević, R., Obradović, M., Sudar-Milovanović, E.,& Isenović, E. R.. (2021). Serum ferritin levels correlate with ultrasonography-determined liver steatosis severity in type 2 diabetes patients with NAFLD. in Endocrine Abstracts.
https://doi.org/10.1530/endoabs.73.AEP294

Mitrović B, Samardžić V, Gluvić Z, Tomasević R, Obradović M, Sudar-Milovanović E, Isenović ER. Serum ferritin levels correlate with ultrasonography-determined liver steatosis severity in type 2 diabetes patients with NAFLD. in Endocrine Abstracts. 2021;.
doi:10.1530/endoabs.73.AEP294 .

Mitrović, Bojan, Samardžić, Vladimir, Gluvić, Zoran, Tomasević, Ratko, Obradović, Milan, Sudar-Milovanović, Emina, Isenović, Esma R., "Serum ferritin levels correlate with ultrasonography-determined liver steatosis severity in type 2 diabetes patients with NAFLD" in Endocrine Abstracts (2021),
https://doi.org/10.1530/endoabs.73.AEP294 . .

TY  - JOUR
AU  - Samardžić, Vladimir
AU  - Banjac, Katarina
AU  - Obradović, Milan
AU  - Gluvić, Zoran
AU  - Isenović, Esma R.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9697
AB  - Thyroid nodules are among highly prevalent thyroid diseases. To make a distinction between benign and malignant thyroid nodules are of cumbersome significance for each endocrinologist. There is no unique and completely accurate diagnostic test, method, or even biomarker that points to a malignant thyroid nodule. Many studies in modern thyroidology are conducted to determine the usefulness of individual biomarkers, which could help clinicians detect thyroid nodules' potential malignant nature. One interesting biomarker with a promising diagnostic potential for the thyroid gland pathological conditions is nitric oxide (NO). Inducible nitric oxide synthase expression is increased in thyroiditis cases and even more in thyroid carcinoma cases, directly connected with increased NO levels in both pathological conditions. We hypothesize that the basal levels of nitrite/nitrate in serum and biopsy washout could indicate nodules' malignant nature.
T2  - Medical Hypotheses
T1  - Could the level of nitrite/nitrate contribute to malignant thyroid nodule diagnostics?
VL  - 150
SP  - 110569
DO  - 10.1016/j.mehy.2021.110569
ER  - 

@article{
author = "Samardžić, Vladimir and Banjac, Katarina and Obradović, Milan and Gluvić, Zoran and Isenović, Esma R.",
year = "2021",
abstract = "Thyroid nodules are among highly prevalent thyroid diseases. To make a distinction between benign and malignant thyroid nodules are of cumbersome significance for each endocrinologist. There is no unique and completely accurate diagnostic test, method, or even biomarker that points to a malignant thyroid nodule. Many studies in modern thyroidology are conducted to determine the usefulness of individual biomarkers, which could help clinicians detect thyroid nodules' potential malignant nature. One interesting biomarker with a promising diagnostic potential for the thyroid gland pathological conditions is nitric oxide (NO). Inducible nitric oxide synthase expression is increased in thyroiditis cases and even more in thyroid carcinoma cases, directly connected with increased NO levels in both pathological conditions. We hypothesize that the basal levels of nitrite/nitrate in serum and biopsy washout could indicate nodules' malignant nature.",
journal = "Medical Hypotheses",
title = "Could the level of nitrite/nitrate contribute to malignant thyroid nodule diagnostics?",
volume = "150",
pages = "110569",
doi = "10.1016/j.mehy.2021.110569"
}

Samardžić, V., Banjac, K., Obradović, M., Gluvić, Z.,& Isenović, E. R.. (2021). Could the level of nitrite/nitrate contribute to malignant thyroid nodule diagnostics?. in Medical Hypotheses, 150, 110569.
https://doi.org/10.1016/j.mehy.2021.110569

Samardžić V, Banjac K, Obradović M, Gluvić Z, Isenović ER. Could the level of nitrite/nitrate contribute to malignant thyroid nodule diagnostics?. in Medical Hypotheses. 2021;150:110569.
doi:10.1016/j.mehy.2021.110569 .

Samardžić, Vladimir, Banjac, Katarina, Obradović, Milan, Gluvić, Zoran, Isenović, Esma R., "Could the level of nitrite/nitrate contribute to malignant thyroid nodule diagnostics?" in Medical Hypotheses, 150 (2021):110569,
https://doi.org/10.1016/j.mehy.2021.110569 . .

TY  - JOUR
AU  - Gluvić, Zoran
AU  - Sudar-Milovanović, Emina
AU  - Samardžić, Vladimir S.
AU  - Obradović, Milan M.
AU  - Jevremović, Danimir P.
AU  - Radenković, Saša P.
AU  - Isenović, Esma R.
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8369
AB  - Primary hypothyroidism can affect lipid metabolism, cardiovascular (CV) function, and overall patients’ quality of life (QoL). Decrease in serum nitric oxide (NO) levels could promote the atherosclerosis acceleration in hypothyroid patients. Our hypothesis is that serum NO level is altered in hypothyroidism; more specifically, we hypothesize that the early vascular changes that can be observed in hypothyroidism could be due to these alterations and that serum NO levels are associated with lipid levels in female patients diagnosed with subclinical hypothyroidism (SCH) or clinical hypothyroidism (CH). Furthermore, since serum NO level is an early marker of atherosclerosis and related CV disorders, which are commonly present and follow hypothyreosis and greatly contribute to overall QoL, we further hypothesized that NO level would correlate with Thyroid Symptom Questionnaire (TSQ) and General Health Questionnaire 12 (GHQ12) scores in hypothyroid patients. A collaterally of our hypothesis was that levothyroxine (LT4) treatment would affect serum NO levels as well as TSQ and GHQ12 scores. Therefore, we have analyzed lipid profile, the level of NO and QoL scores in female patients diagnosed with SCH and CH in order to determine the correlation between NO and generic and thyroid disease symptoms in treatment naïve SCH and CH patients and after LT4 treatment and laboratory euthyroidism achievement. As a consequence of our hypothesis is that measurement of serum NO level in SCH and CH patients may be an innovative way to improve LT4 treatment efficacy. This assumption could have a practical significance for future investigations regarding the management of hypothyroidism treatment protocols in current guidelines. © 2019 Elsevier Ltd
T2  - Medical Hypotheses
T1  - Serum nitric oxide levels correlate with quality of life questionnaires scores of hypothyroid females
VL  - 131
SP  - 109299
DO  - 10.1016/j.mehy.2019.109299
ER  - 

@article{
author = "Gluvić, Zoran and Sudar-Milovanović, Emina and Samardžić, Vladimir S. and Obradović, Milan M. and Jevremović, Danimir P. and Radenković, Saša P. and Isenović, Esma R.",
year = "2019",
abstract = "Primary hypothyroidism can affect lipid metabolism, cardiovascular (CV) function, and overall patients’ quality of life (QoL). Decrease in serum nitric oxide (NO) levels could promote the atherosclerosis acceleration in hypothyroid patients. Our hypothesis is that serum NO level is altered in hypothyroidism; more specifically, we hypothesize that the early vascular changes that can be observed in hypothyroidism could be due to these alterations and that serum NO levels are associated with lipid levels in female patients diagnosed with subclinical hypothyroidism (SCH) or clinical hypothyroidism (CH). Furthermore, since serum NO level is an early marker of atherosclerosis and related CV disorders, which are commonly present and follow hypothyreosis and greatly contribute to overall QoL, we further hypothesized that NO level would correlate with Thyroid Symptom Questionnaire (TSQ) and General Health Questionnaire 12 (GHQ12) scores in hypothyroid patients. A collaterally of our hypothesis was that levothyroxine (LT4) treatment would affect serum NO levels as well as TSQ and GHQ12 scores. Therefore, we have analyzed lipid profile, the level of NO and QoL scores in female patients diagnosed with SCH and CH in order to determine the correlation between NO and generic and thyroid disease symptoms in treatment naïve SCH and CH patients and after LT4 treatment and laboratory euthyroidism achievement. As a consequence of our hypothesis is that measurement of serum NO level in SCH and CH patients may be an innovative way to improve LT4 treatment efficacy. This assumption could have a practical significance for future investigations regarding the management of hypothyroidism treatment protocols in current guidelines. © 2019 Elsevier Ltd",
journal = "Medical Hypotheses",
title = "Serum nitric oxide levels correlate with quality of life questionnaires scores of hypothyroid females",
volume = "131",
pages = "109299",
doi = "10.1016/j.mehy.2019.109299"
}

Gluvić, Z., Sudar-Milovanović, E., Samardžić, V. S., Obradović, M. M., Jevremović, D. P., Radenković, S. P.,& Isenović, E. R.. (2019). Serum nitric oxide levels correlate with quality of life questionnaires scores of hypothyroid females. in Medical Hypotheses, 131, 109299.
https://doi.org/10.1016/j.mehy.2019.109299

Gluvić Z, Sudar-Milovanović E, Samardžić VS, Obradović MM, Jevremović DP, Radenković SP, Isenović ER. Serum nitric oxide levels correlate with quality of life questionnaires scores of hypothyroid females. in Medical Hypotheses. 2019;131:109299.
doi:10.1016/j.mehy.2019.109299 .

Gluvić, Zoran, Sudar-Milovanović, Emina, Samardžić, Vladimir S., Obradović, Milan M., Jevremović, Danimir P., Radenković, Saša P., Isenović, Esma R., "Serum nitric oxide levels correlate with quality of life questionnaires scores of hypothyroid females" in Medical Hypotheses, 131 (2019):109299,
https://doi.org/10.1016/j.mehy.2019.109299 . .

TY  - JOUR
AU  - Gluvić, Zoran
AU  - Obradović, Milan M.
AU  - Lačković, Milena
AU  - Samardžić, Vladimir S.
AU  - Tica Jevtic, Jelena
AU  - Essack, Magbubah
AU  - Bajić, Vladimir B.
AU  - Isenović, Esma R.
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8484
AB  - What is known and objective: The HbA1C marker used in assessing diabetes control quality is not sufficient in diabetes patients with thalassaemia. Case description: A male diabetic patient with thalassaemia was hospitalized due to distal neuropathic pain, right toe trophic ulcer, unacceptable five-point glycaemic profile and recommended HbA1C value. After simultaneously initiated insulin therapy and management of ulcer by hyperbaric oxygen, the patient showed improved glycaemic control and ulcer healing, which led to the patient's discharge. What is new and conclusion: In thalassaemia and haemoglobinopathies, due to discrepancies in the five-point glycaemic profile and HbA1C values, it is necessary to measure HbA1C with a different method or to determine HbA1C and fructosamine simultaneously. © 2019 The Authors. Journal of Clinical Pharmacy and Therapeutics Published by John Wiley & Sons Ltd.
T2  - Journal of Clinical Pharmacy and Therapeutics
T1  - HbA1C as a marker of retrograde glycaemic control in diabetes patient with co-existed beta-thalassaemia: A case report and a literature review
VL  - 45
IS  - 2
SP  - 379
EP  - 383
DO  - 10.1111/jcpt.13073
ER  - 

@article{
author = "Gluvić, Zoran and Obradović, Milan M. and Lačković, Milena and Samardžić, Vladimir S. and Tica Jevtic, Jelena and Essack, Magbubah and Bajić, Vladimir B. and Isenović, Esma R.",
year = "2019",
abstract = "What is known and objective: The HbA1C marker used in assessing diabetes control quality is not sufficient in diabetes patients with thalassaemia. Case description: A male diabetic patient with thalassaemia was hospitalized due to distal neuropathic pain, right toe trophic ulcer, unacceptable five-point glycaemic profile and recommended HbA1C value. After simultaneously initiated insulin therapy and management of ulcer by hyperbaric oxygen, the patient showed improved glycaemic control and ulcer healing, which led to the patient's discharge. What is new and conclusion: In thalassaemia and haemoglobinopathies, due to discrepancies in the five-point glycaemic profile and HbA1C values, it is necessary to measure HbA1C with a different method or to determine HbA1C and fructosamine simultaneously. © 2019 The Authors. Journal of Clinical Pharmacy and Therapeutics Published by John Wiley & Sons Ltd.",
journal = "Journal of Clinical Pharmacy and Therapeutics",
title = "HbA1C as a marker of retrograde glycaemic control in diabetes patient with co-existed beta-thalassaemia: A case report and a literature review",
volume = "45",
number = "2",
pages = "379-383",
doi = "10.1111/jcpt.13073"
}

Gluvić, Z., Obradović, M. M., Lačković, M., Samardžić, V. S., Tica Jevtic, J., Essack, M., Bajić, V. B.,& Isenović, E. R.. (2019). HbA1C as a marker of retrograde glycaemic control in diabetes patient with co-existed beta-thalassaemia: A case report and a literature review. in Journal of Clinical Pharmacy and Therapeutics, 45(2), 379-383.
https://doi.org/10.1111/jcpt.13073

Gluvić Z, Obradović MM, Lačković M, Samardžić VS, Tica Jevtic J, Essack M, Bajić VB, Isenović ER. HbA1C as a marker of retrograde glycaemic control in diabetes patient with co-existed beta-thalassaemia: A case report and a literature review. in Journal of Clinical Pharmacy and Therapeutics. 2019;45(2):379-383.
doi:10.1111/jcpt.13073 .

Gluvić, Zoran, Obradović, Milan M., Lačković, Milena, Samardžić, Vladimir S., Tica Jevtic, Jelena, Essack, Magbubah, Bajić, Vladimir B., Isenović, Esma R., "HbA1C as a marker of retrograde glycaemic control in diabetes patient with co-existed beta-thalassaemia: A case report and a literature review" in Journal of Clinical Pharmacy and Therapeutics, 45, no. 2 (2019):379-383,
https://doi.org/10.1111/jcpt.13073 . .

TY  - JOUR
AU  - Gluvić, Zoran
AU  - Mitrović, Bojan
AU  - Lačković, Milena
AU  - Samardžić, Vladimir
AU  - Jakšić, Dunja
AU  - Pavlović, Aleksandar
AU  - Tomašević, Ratko
AU  - Obradović, Milan M.
AU  - Isenović, Esma R.
PY  - 2018
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10153
AB  - Staphylococcal toxic shock syndrome (STSS) is typically detected in newborns and children but can be seen in adults occasionally. In such a case, it points out usually on some immune system dysfunction. We present a case of a critically-ill adult male with STSS and symptoms and signs of serious systemic infection (hemodynamic instability, acute renal failure, mental confusion). After the completion of applied treatment (antistaphylococcal antimicrobials, hemodialysis, vasopressor, supportive, and symptomatic therapy), complete restoration of presented patients' derangements was achieved. Timely diagnosis and appropriate treatment is the mainstay in the management of STSS in adults.
AB  - Stafilokokni toksični šok sindrom (STŠS) se obično javlja kod novorođenčadi i dece, ali se povremeno može javiti i kod odraslih. U tom slučaju, obično ukazuje na disfunkciju imunog sistema. Prikazan je slučaj kritično-obolelog odraslog muškarca sa STŠS i simptomima i znacima životno-ugrožavajuće sistemske infekcije (hemodinamska nestabilnost, akutna insuficijencija bubrega, konfuzija). Nakon završenog lečenja (anti-stafilokoni antibiotici, hemodijaliza, vazopresori, suportivna i simptomatska terapija), postignuta je potpuna remisija kod obolelog. Pravovremena dijagnostika i adekvatan tretman je glavno uporište u lečenju STŠS kod odraslih.
T2  - Materia medica
T1  - An old fox is trapped: The staphylococcal toxic shock syndrome in male adult: Case report
T1  - Uhvaćen je stari lisac - stafilokokni toksični šok sindrom kod odraslog muškarca - prikaz slučaja
VL  - 34
IS  - 3
SP  - 1608
EP  - 1612
DO  - 10.5937/MatMed1801608G
ER  - 

@article{
author = "Gluvić, Zoran and Mitrović, Bojan and Lačković, Milena and Samardžić, Vladimir and Jakšić, Dunja and Pavlović, Aleksandar and Tomašević, Ratko and Obradović, Milan M. and Isenović, Esma R.",
year = "2018",
abstract = "Staphylococcal toxic shock syndrome (STSS) is typically detected in newborns and children but can be seen in adults occasionally. In such a case, it points out usually on some immune system dysfunction. We present a case of a critically-ill adult male with STSS and symptoms and signs of serious systemic infection (hemodynamic instability, acute renal failure, mental confusion). After the completion of applied treatment (antistaphylococcal antimicrobials, hemodialysis, vasopressor, supportive, and symptomatic therapy), complete restoration of presented patients' derangements was achieved. Timely diagnosis and appropriate treatment is the mainstay in the management of STSS in adults., Stafilokokni toksični šok sindrom (STŠS) se obično javlja kod novorođenčadi i dece, ali se povremeno može javiti i kod odraslih. U tom slučaju, obično ukazuje na disfunkciju imunog sistema. Prikazan je slučaj kritično-obolelog odraslog muškarca sa STŠS i simptomima i znacima životno-ugrožavajuće sistemske infekcije (hemodinamska nestabilnost, akutna insuficijencija bubrega, konfuzija). Nakon završenog lečenja (anti-stafilokoni antibiotici, hemodijaliza, vazopresori, suportivna i simptomatska terapija), postignuta je potpuna remisija kod obolelog. Pravovremena dijagnostika i adekvatan tretman je glavno uporište u lečenju STŠS kod odraslih.",
journal = "Materia medica",
title = "An old fox is trapped: The staphylococcal toxic shock syndrome in male adult: Case report, Uhvaćen je stari lisac - stafilokokni toksični šok sindrom kod odraslog muškarca - prikaz slučaja",
volume = "34",
number = "3",
pages = "1608-1612",
doi = "10.5937/MatMed1801608G"
}

Gluvić, Z., Mitrović, B., Lačković, M., Samardžić, V., Jakšić, D., Pavlović, A., Tomašević, R., Obradović, M. M.,& Isenović, E. R.. (2018). An old fox is trapped: The staphylococcal toxic shock syndrome in male adult: Case report. in Materia medica, 34(3), 1608-1612.
https://doi.org/10.5937/MatMed1801608G

Gluvić Z, Mitrović B, Lačković M, Samardžić V, Jakšić D, Pavlović A, Tomašević R, Obradović MM, Isenović ER. An old fox is trapped: The staphylococcal toxic shock syndrome in male adult: Case report. in Materia medica. 2018;34(3):1608-1612.
doi:10.5937/MatMed1801608G .

Gluvić, Zoran, Mitrović, Bojan, Lačković, Milena, Samardžić, Vladimir, Jakšić, Dunja, Pavlović, Aleksandar, Tomašević, Ratko, Obradović, Milan M., Isenović, Esma R., "An old fox is trapped: The staphylococcal toxic shock syndrome in male adult: Case report" in Materia medica, 34, no. 3 (2018):1608-1612,
https://doi.org/10.5937/MatMed1801608G . .

TY  - JOUR
AU  - Gluvić, Zoran
AU  - Samardžić, Vladimir
AU  - Zarić, Božidarka
AU  - Đurković, Veslinka
AU  - Mladenović, Violeta
AU  - Stojanović, Marko
AU  - Isenović, Esma R.
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12032
AB  - Congenital adrenal hyperplasia (CAH) is a rare genetic disorder which is caused by autosomal recessive mutations in genes, encoding enzymes involved in the process of glyco- and/ or the mineralocorticoid synthesis. It is most common 21-hydroxylase deficiency. Renal disease in patients with CAH is not common but is usually associated with hypertension. Here we present the case of hypotensive terminal chronic renal diseases, which required the support of hemodialysis in patients with noncompliance CAH intermediation with a loss of salt. Also, we analyzed the influence of hemodialysis treatment on biochemical indicators of quality of CAH treatment.
AB  - Kongenitalna adrenalna hiperplazija (KAH) je redak genetski poremećaj, koji je uzrokovan autozomno recesivnom mutacijom gena, koji enkodiraju enzime uključene u procesu glikoi/ili mineralokortikoidne sinteze. Najčešće se javlja deficit 21-hidroksilaze. Bubrežna bolest kod obolelih od KAH nije česta, a obično se povezuje sa hipertenzijom. Prikazuje se slučaj hipotenzivne terminalne hronične bubrežne bolesti, koja je zahtevala hemodijaliznu potporu kod nekomplijantnog bolesnika sa KAH sa gubitkom soli. Takođe, prikazan je uticaj hemodijaliznog tretmana na biohemijske pokazatelje kvaliteta tretmana KAH.
T2  - Medical investigation
T1  - Terminal chronic kidney disease with arterial hypotension in a patient with classic congenital adrenal hyperplasia
T1  - Terminalna hronična bolest bubrega sa arterijskom hipotenzijom kod obolelog od klasične kongenitalne adrenalne hiperplazije
VL  - 51
IS  - 3
SP  - 29
EP  - 33
DO  - 10.5937/MedIst1703029G
ER  - 

@article{
author = "Gluvić, Zoran and Samardžić, Vladimir and Zarić, Božidarka and Đurković, Veslinka and Mladenović, Violeta and Stojanović, Marko and Isenović, Esma R.",
year = "2017",
abstract = "Congenital adrenal hyperplasia (CAH) is a rare genetic disorder which is caused by autosomal recessive mutations in genes, encoding enzymes involved in the process of glyco- and/ or the mineralocorticoid synthesis. It is most common 21-hydroxylase deficiency. Renal disease in patients with CAH is not common but is usually associated with hypertension. Here we present the case of hypotensive terminal chronic renal diseases, which required the support of hemodialysis in patients with noncompliance CAH intermediation with a loss of salt. Also, we analyzed the influence of hemodialysis treatment on biochemical indicators of quality of CAH treatment., Kongenitalna adrenalna hiperplazija (KAH) je redak genetski poremećaj, koji je uzrokovan autozomno recesivnom mutacijom gena, koji enkodiraju enzime uključene u procesu glikoi/ili mineralokortikoidne sinteze. Najčešće se javlja deficit 21-hidroksilaze. Bubrežna bolest kod obolelih od KAH nije česta, a obično se povezuje sa hipertenzijom. Prikazuje se slučaj hipotenzivne terminalne hronične bubrežne bolesti, koja je zahtevala hemodijaliznu potporu kod nekomplijantnog bolesnika sa KAH sa gubitkom soli. Takođe, prikazan je uticaj hemodijaliznog tretmana na biohemijske pokazatelje kvaliteta tretmana KAH.",
journal = "Medical investigation",
title = "Terminal chronic kidney disease with arterial hypotension in a patient with classic congenital adrenal hyperplasia, Terminalna hronična bolest bubrega sa arterijskom hipotenzijom kod obolelog od klasične kongenitalne adrenalne hiperplazije",
volume = "51",
number = "3",
pages = "29-33",
doi = "10.5937/MedIst1703029G"
}

Gluvić, Z., Samardžić, V., Zarić, B., Đurković, V., Mladenović, V., Stojanović, M.,& Isenović, E. R.. (2017). Terminal chronic kidney disease with arterial hypotension in a patient with classic congenital adrenal hyperplasia. in Medical investigation, 51(3), 29-33.
https://doi.org/10.5937/MedIst1703029G

Gluvić Z, Samardžić V, Zarić B, Đurković V, Mladenović V, Stojanović M, Isenović ER. Terminal chronic kidney disease with arterial hypotension in a patient with classic congenital adrenal hyperplasia. in Medical investigation. 2017;51(3):29-33.
doi:10.5937/MedIst1703029G .

Gluvić, Zoran, Samardžić, Vladimir, Zarić, Božidarka, Đurković, Veslinka, Mladenović, Violeta, Stojanović, Marko, Isenović, Esma R., "Terminal chronic kidney disease with arterial hypotension in a patient with classic congenital adrenal hyperplasia" in Medical investigation, 51, no. 3 (2017):29-33,
https://doi.org/10.5937/MedIst1703029G . .

TY  - JOUR
AU  - Popin-Tarić, Marija
AU  - Gluvić, Zoran
AU  - Mitrović, Bojan
AU  - Samardžić, Vladimir
AU  - Lačković, Milena
AU  - Vasić-Vlaisavljević, Anita
AU  - Stanojević, Aleksandar
AU  - Kulić, Adrijana
AU  - Libek, Vesna
AU  - Resanović, Ivana
AU  - Isenović, Esma R.
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10156
AB  - U okviru ovog rada prikazan je slučaj bolesnika sa komplikovanim akutnim dislipidemijskim pankreatitisom u čijem je zbrinjavanju učestvovao tim, koji su činili endokrinolozi, gastroenterolozi i transfuziolozi. Dislipidemija, prevashodno tip IV dislipidemije, predstavlja čest uzrok nastanka akutnog pankreatitisa u populaciji mladih ljudi, posebno u slučajevima nezadovoljavajuće komplijanse (neredovno uzimanje preporučenih fibrata i nepridržavanje higijensko-dijetetskog režima). Tretman akutnog pankreatitisa se nezavisno od etiologije, zbog težine stanja, kompleksnosti lečenja i monitoringa bolesnika, sprovodi u Jedinicama intenzivnog lečenja. U slučajevima kada je dislipidemija uzrok akutnog pankreatitisa, često se u sklopu akutnog zbrinjavanja sprovodi i terapijska izmena plazme, kojom se brzo i značajno koriguju nivoi lipida, prevashodno triglicerida. Terapijska izmena plazme zahteva aktivnost transfuzioloških ekipa, koje su u manjim centrima, često nedostupne.
AB  - This article presents a case of patient with acute and complicated dyslipidaemic pancreatitis, managed by team, consisted of the endocrinologists, gastroenterologists and transfusiologists. Dyslipidaemia, predominantly type IV, is a common cause of acute pancreatitis in young patients, especially in the cases of poor compliance (irregular taking of recommended fibrates and failure to comply with the dietary regime). The treatment of acute pancreatitis, regardless of the aetiology, is due to the severity of the condition, the complexity of the treatment, and the monitoring of patients, in the Intensive Care Units. In cases where dyslipidaemia is the cause of acute pancreatitis, in the context of acute care, a therapeutic plasma exchange is often performed. It rapidly and significantly corrects lipid levels, primarily triglycerides. Therapeutic plasma exchange requires the activity of transfusiology team, which are often unavailable in smaller hospitals.
T2  - Materia medica
T1  - Prikaz timskog zbrinjavanja obolelog od akutnog teškog dislipidemijskog pankreatitisa - iskustvo jednog tercijernog zdravstvenog centra
T1  - The team management of patient suffered of acute severe dyslipidaemic pancreatitis: The experience of one tertiary health centre
VL  - 33
IS  - 3
SP  - 1557
EP  - 1562
DO  - 10.5937/MatMed1703557P
ER  - 

@article{
author = "Popin-Tarić, Marija and Gluvić, Zoran and Mitrović, Bojan and Samardžić, Vladimir and Lačković, Milena and Vasić-Vlaisavljević, Anita and Stanojević, Aleksandar and Kulić, Adrijana and Libek, Vesna and Resanović, Ivana and Isenović, Esma R.",
year = "2017",
abstract = "U okviru ovog rada prikazan je slučaj bolesnika sa komplikovanim akutnim dislipidemijskim pankreatitisom u čijem je zbrinjavanju učestvovao tim, koji su činili endokrinolozi, gastroenterolozi i transfuziolozi. Dislipidemija, prevashodno tip IV dislipidemije, predstavlja čest uzrok nastanka akutnog pankreatitisa u populaciji mladih ljudi, posebno u slučajevima nezadovoljavajuće komplijanse (neredovno uzimanje preporučenih fibrata i nepridržavanje higijensko-dijetetskog režima). Tretman akutnog pankreatitisa se nezavisno od etiologije, zbog težine stanja, kompleksnosti lečenja i monitoringa bolesnika, sprovodi u Jedinicama intenzivnog lečenja. U slučajevima kada je dislipidemija uzrok akutnog pankreatitisa, često se u sklopu akutnog zbrinjavanja sprovodi i terapijska izmena plazme, kojom se brzo i značajno koriguju nivoi lipida, prevashodno triglicerida. Terapijska izmena plazme zahteva aktivnost transfuzioloških ekipa, koje su u manjim centrima, često nedostupne., This article presents a case of patient with acute and complicated dyslipidaemic pancreatitis, managed by team, consisted of the endocrinologists, gastroenterologists and transfusiologists. Dyslipidaemia, predominantly type IV, is a common cause of acute pancreatitis in young patients, especially in the cases of poor compliance (irregular taking of recommended fibrates and failure to comply with the dietary regime). The treatment of acute pancreatitis, regardless of the aetiology, is due to the severity of the condition, the complexity of the treatment, and the monitoring of patients, in the Intensive Care Units. In cases where dyslipidaemia is the cause of acute pancreatitis, in the context of acute care, a therapeutic plasma exchange is often performed. It rapidly and significantly corrects lipid levels, primarily triglycerides. Therapeutic plasma exchange requires the activity of transfusiology team, which are often unavailable in smaller hospitals.",
journal = "Materia medica",
title = "Prikaz timskog zbrinjavanja obolelog od akutnog teškog dislipidemijskog pankreatitisa - iskustvo jednog tercijernog zdravstvenog centra, The team management of patient suffered of acute severe dyslipidaemic pancreatitis: The experience of one tertiary health centre",
volume = "33",
number = "3",
pages = "1557-1562",
doi = "10.5937/MatMed1703557P"
}

Popin-Tarić, M., Gluvić, Z., Mitrović, B., Samardžić, V., Lačković, M., Vasić-Vlaisavljević, A., Stanojević, A., Kulić, A., Libek, V., Resanović, I.,& Isenović, E. R.. (2017). Prikaz timskog zbrinjavanja obolelog od akutnog teškog dislipidemijskog pankreatitisa - iskustvo jednog tercijernog zdravstvenog centra. in Materia medica, 33(3), 1557-1562.
https://doi.org/10.5937/MatMed1703557P

Popin-Tarić M, Gluvić Z, Mitrović B, Samardžić V, Lačković M, Vasić-Vlaisavljević A, Stanojević A, Kulić A, Libek V, Resanović I, Isenović ER. Prikaz timskog zbrinjavanja obolelog od akutnog teškog dislipidemijskog pankreatitisa - iskustvo jednog tercijernog zdravstvenog centra. in Materia medica. 2017;33(3):1557-1562.
doi:10.5937/MatMed1703557P .

Popin-Tarić, Marija, Gluvić, Zoran, Mitrović, Bojan, Samardžić, Vladimir, Lačković, Milena, Vasić-Vlaisavljević, Anita, Stanojević, Aleksandar, Kulić, Adrijana, Libek, Vesna, Resanović, Ivana, Isenović, Esma R., "Prikaz timskog zbrinjavanja obolelog od akutnog teškog dislipidemijskog pankreatitisa - iskustvo jednog tercijernog zdravstvenog centra" in Materia medica, 33, no. 3 (2017):1557-1562,
https://doi.org/10.5937/MatMed1703557P . .

TY  - JOUR
AU  - Mitrović, Bojan
AU  - Gluvić, Zoran
AU  - Obradović, Milan M.
AU  - Lačković, Milena
AU  - Samardžić, Vladimir
AU  - Ćirić, Jasmina
AU  - Isenović, Esma R.
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10311
AB  - Primarni hipotireoidizam negativno utiče na kvalitet života obolelih. Poboljšanje kvaliteta života očekuje se uspostavljanjem eutireoidnog stanja primenom levotiroksina. Kvalitet života se može "proceniti" primenom različitih upitnika, poput upitnika opšteg zdravlja (GHQ12; engl. General Health Questionnaire) i tireoidno specifičnog upitnika (TSQ; engl. Thyroid Symptom Questionnaire). Ciljevi ovog rada su: sumiranje standardno i modifikovano rangiranih odgovora oba upitnika u skorove; ispitivanje postojanja razlika u apsolutnim vrednostima skorova među grupama ispitanika; svrstavanje dobijenih skorova u različite klastere (bez poremećaja, manji poremećaj, veliki poremećaj), i ispitivanje postojanja razlika u distribuciji frekvencija ispitanika među njima. Studija preseka je sprovedena u KBC Zemun i obuhvatila je 90 ispitanica, koje su bile podeljene u tri jednake grupe (30 po grupi): hipotireoidnu bez terapije, eutiroidnu sa levotiroksinom i kontrolnu, eutireoidnu grupu bez terapije. Ispitanice su zaokruživale svoj odgovor na postavljena pitanja upitnika, koji je potom rangovno transformisan pomoću dva modelastandardnog i modifikovanog, a potom zbirno sumiran. Za statističku analizu korišćen je softver SPSS for Windows 18.0. Prosečan nivo tireostimulišućeg hormona (TSH) u ispitivanoj populaciji je iznosio 1,3±0,3 (1,1-2,2) mU/L. Prosečni TSQm, TSQs, GHQm and GHQs skorovi su bili 14±7, 13±6, 11±7, i 11±6 i razlikovali su se među grupama. Najniži skorovi su registrovani u grupi levotiroksinom-tretiranih, nezavisno od modela rangiranja, pri čemu je nivo TSH ukazivao na adekvatnu supstituciju levotiroksinom. Prosečni TSQs/TSQm i GHQs/GHQm skorovi pokazuju međusobnu statističku korelaciju. Skorovi i skorom-definisani klasteri oba primenjena upitnika odgovaraju kliničkoj prezentaciji prikazanoj kroz grupe ispitivane populacije. S obzirom da se prosečni skorovi upitnika međusobno razlikuju, a da oba modela rangovne transformacije istog upitnika daju sličan skor, zaključujemo da je dovoljno koristiti po jedan upitnik iz obe kategorije instrumenata za ispitivanje kvaliteta života. Jednostavnost primene ovih upitnika, nezavisno od modela transformacije dobijenih odgovora u rangove, omogućava njihovu primenu pri započinjanju supstitucije levotiroksinom, ali takođe i proceni efikasnosti primenjene terapije.
AB  - Primary hypothyroidism negatively affects patients' quality of life. Improving the quality of life is expected by establishing eutyreoid state using levothyroxine therapy. The quality of life can be "assessed" by applying various questionnaires, such as the general health questionnaire (GHQ12) and thyroid symptom questionnaire (TSQ). The aims of present study were to: sum standard and modified-ranked answers of both questionnaires, rank the scores, test differences in the absolute values of the scores between the groups, classify obtained scores in different clusters (no distress, a minor, and major distress), and test differences in the distribution of frequencies of the respondents among them. Cross-sectional study was conducted in Zemun Clinical Hospital and it included 90 subjects. The subjects were divided into three equal groups (30 subjects per group): hypothyroid without treatment, euthyroid with levothyroxine, and control, euthyroid group without treatment. The subjects answered the questions in the questionnaire, and the answers were then transformed into the ranking of two modelsstandard and modified, and then summarized. Statistical analysis was performed using the SPSS for Windows 18.0. The average level of thyroid stimulating hormone (TSH) in the study population was 1.3 ± 0.3 (1.1-2.2) mU/L. Average TSQm, TSQs, GHQm and GHQs scores were 14±7, 13±6, 11±7 and 11±6 and differed between groups. The lowest scores were registered in the group of levothyroxine-treated, regardless of the ranking models, with the level of TSH that indicates an adequate substitution levothyroxine. Average TSQs/TSQm and GHQs/GHQm scores show a statistical correlation with each other. Scores and scores-defined clusters of both questionnaires are appropriate for clinical presentation shown by specific groups of the population. Considering that the average scores of the questionnaire differ from each other, and that both models rank-transformation of the same questionnaire give a similar score, it is sufficient to use one questionnaire from both categories of instruments for testing the quality of life. The ease of applying these questionnaires, independent of the transformation obtained in response ranges and their application when starting levothyroxine substitution, were used to assess the effectiveness of the therapy.
T2  - Medicinska istraživanja
T1  - Ispitivanje kvaliteta života obolelih od primarne hipotireoze primenom različitih upitnika i metoda njihove obrade
T1  - Primary hypothyroidism quality of life assessment by application of different questionnaires and its different processing
VL  - 50
IS  - 2
SP  - 1
EP  - 6
DO  - 10.5937/MedIst1602001M
ER  - 

@article{
author = "Mitrović, Bojan and Gluvić, Zoran and Obradović, Milan M. and Lačković, Milena and Samardžić, Vladimir and Ćirić, Jasmina and Isenović, Esma R.",
year = "2016",
abstract = "Primarni hipotireoidizam negativno utiče na kvalitet života obolelih. Poboljšanje kvaliteta života očekuje se uspostavljanjem eutireoidnog stanja primenom levotiroksina. Kvalitet života se može "proceniti" primenom različitih upitnika, poput upitnika opšteg zdravlja (GHQ12; engl. General Health Questionnaire) i tireoidno specifičnog upitnika (TSQ; engl. Thyroid Symptom Questionnaire). Ciljevi ovog rada su: sumiranje standardno i modifikovano rangiranih odgovora oba upitnika u skorove; ispitivanje postojanja razlika u apsolutnim vrednostima skorova među grupama ispitanika; svrstavanje dobijenih skorova u različite klastere (bez poremećaja, manji poremećaj, veliki poremećaj), i ispitivanje postojanja razlika u distribuciji frekvencija ispitanika među njima. Studija preseka je sprovedena u KBC Zemun i obuhvatila je 90 ispitanica, koje su bile podeljene u tri jednake grupe (30 po grupi): hipotireoidnu bez terapije, eutiroidnu sa levotiroksinom i kontrolnu, eutireoidnu grupu bez terapije. Ispitanice su zaokruživale svoj odgovor na postavljena pitanja upitnika, koji je potom rangovno transformisan pomoću dva modelastandardnog i modifikovanog, a potom zbirno sumiran. Za statističku analizu korišćen je softver SPSS for Windows 18.0. Prosečan nivo tireostimulišućeg hormona (TSH) u ispitivanoj populaciji je iznosio 1,3±0,3 (1,1-2,2) mU/L. Prosečni TSQm, TSQs, GHQm and GHQs skorovi su bili 14±7, 13±6, 11±7, i 11±6 i razlikovali su se među grupama. Najniži skorovi su registrovani u grupi levotiroksinom-tretiranih, nezavisno od modela rangiranja, pri čemu je nivo TSH ukazivao na adekvatnu supstituciju levotiroksinom. Prosečni TSQs/TSQm i GHQs/GHQm skorovi pokazuju međusobnu statističku korelaciju. Skorovi i skorom-definisani klasteri oba primenjena upitnika odgovaraju kliničkoj prezentaciji prikazanoj kroz grupe ispitivane populacije. S obzirom da se prosečni skorovi upitnika međusobno razlikuju, a da oba modela rangovne transformacije istog upitnika daju sličan skor, zaključujemo da je dovoljno koristiti po jedan upitnik iz obe kategorije instrumenata za ispitivanje kvaliteta života. Jednostavnost primene ovih upitnika, nezavisno od modela transformacije dobijenih odgovora u rangove, omogućava njihovu primenu pri započinjanju supstitucije levotiroksinom, ali takođe i proceni efikasnosti primenjene terapije., Primary hypothyroidism negatively affects patients' quality of life. Improving the quality of life is expected by establishing eutyreoid state using levothyroxine therapy. The quality of life can be "assessed" by applying various questionnaires, such as the general health questionnaire (GHQ12) and thyroid symptom questionnaire (TSQ). The aims of present study were to: sum standard and modified-ranked answers of both questionnaires, rank the scores, test differences in the absolute values of the scores between the groups, classify obtained scores in different clusters (no distress, a minor, and major distress), and test differences in the distribution of frequencies of the respondents among them. Cross-sectional study was conducted in Zemun Clinical Hospital and it included 90 subjects. The subjects were divided into three equal groups (30 subjects per group): hypothyroid without treatment, euthyroid with levothyroxine, and control, euthyroid group without treatment. The subjects answered the questions in the questionnaire, and the answers were then transformed into the ranking of two modelsstandard and modified, and then summarized. Statistical analysis was performed using the SPSS for Windows 18.0. The average level of thyroid stimulating hormone (TSH) in the study population was 1.3 ± 0.3 (1.1-2.2) mU/L. Average TSQm, TSQs, GHQm and GHQs scores were 14±7, 13±6, 11±7 and 11±6 and differed between groups. The lowest scores were registered in the group of levothyroxine-treated, regardless of the ranking models, with the level of TSH that indicates an adequate substitution levothyroxine. Average TSQs/TSQm and GHQs/GHQm scores show a statistical correlation with each other. Scores and scores-defined clusters of both questionnaires are appropriate for clinical presentation shown by specific groups of the population. Considering that the average scores of the questionnaire differ from each other, and that both models rank-transformation of the same questionnaire give a similar score, it is sufficient to use one questionnaire from both categories of instruments for testing the quality of life. The ease of applying these questionnaires, independent of the transformation obtained in response ranges and their application when starting levothyroxine substitution, were used to assess the effectiveness of the therapy.",
journal = "Medicinska istraživanja",
title = "Ispitivanje kvaliteta života obolelih od primarne hipotireoze primenom različitih upitnika i metoda njihove obrade, Primary hypothyroidism quality of life assessment by application of different questionnaires and its different processing",
volume = "50",
number = "2",
pages = "1-6",
doi = "10.5937/MedIst1602001M"
}

Mitrović, B., Gluvić, Z., Obradović, M. M., Lačković, M., Samardžić, V., Ćirić, J.,& Isenović, E. R.. (2016). Ispitivanje kvaliteta života obolelih od primarne hipotireoze primenom različitih upitnika i metoda njihove obrade. in Medicinska istraživanja, 50(2), 1-6.
https://doi.org/10.5937/MedIst1602001M

Mitrović B, Gluvić Z, Obradović MM, Lačković M, Samardžić V, Ćirić J, Isenović ER. Ispitivanje kvaliteta života obolelih od primarne hipotireoze primenom različitih upitnika i metoda njihove obrade. in Medicinska istraživanja. 2016;50(2):1-6.
doi:10.5937/MedIst1602001M .

Mitrović, Bojan, Gluvić, Zoran, Obradović, Milan M., Lačković, Milena, Samardžić, Vladimir, Ćirić, Jasmina, Isenović, Esma R., "Ispitivanje kvaliteta života obolelih od primarne hipotireoze primenom različitih upitnika i metoda njihove obrade" in Medicinska istraživanja, 50, no. 2 (2016):1-6,
https://doi.org/10.5937/MedIst1602001M . .

TY  - JOUR
AU  - Mitrović, Bojan
AU  - Gluvić, Zoran
AU  - Samardžić, Vladimir
AU  - Obradović, Milan M.
AU  - Lačković, Milena
AU  - Cvetković, Zorica
AU  - Pavlović, Aleksandar
AU  - Isenović, Esma R.
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10310
AB  - Tromboza portne vene (TPV) je retko oboljenje splanhničke cirkulacije, koje najčešće nastaje sadejstvom više lokalnih i/ili sistemskih faktora. Ukoliko TPV komplikuje osnovnu bolest, ona pogoršava njenu prognozu, a konkomitantno se leče obe. Iako se najčešće javlja u sklopu ciroze jetre, malignih bolesti abdominalnih organa i nekih hemopatija, postoji i idiopatska TPV, koja se definiše ekskluzijom svih poznatih uzroka TPV. U ovom radu je prikazan slučaj hronične idioptaske TPV.
AB  - Portal vein thrombosis (PVT) is a rare disorder of splanchnic circulation, frequently caused by concomitant presence of local and/or systemic factors. When portal vein thrombosis complicates causative diseases, it will worsen their prognosis, and in such a case, the causative disease and PVT are treated concomitantly. Despite the fact that PVT frequently complicates liver cirrhosis, intraabdominal malignancies, and some hematological diseases, after all causes are excluded, one can define idiopathic portal vein thrombosis. In this study we have described the case of idiopathic chronical portal vein thrombosis.
T2  - Medicinska istraživanja
T1  - Hronična idiopatska Tromboza portne vene - prikaz slučaja
T1  - Chronic idiopathic portal vein thrombosis: A case study
VL  - 50
IS  - 2
SP  - 13
EP  - 17
DO  - 10.5937/MedIst1602013M
ER  - 

@article{
author = "Mitrović, Bojan and Gluvić, Zoran and Samardžić, Vladimir and Obradović, Milan M. and Lačković, Milena and Cvetković, Zorica and Pavlović, Aleksandar and Isenović, Esma R.",
year = "2016",
abstract = "Tromboza portne vene (TPV) je retko oboljenje splanhničke cirkulacije, koje najčešće nastaje sadejstvom više lokalnih i/ili sistemskih faktora. Ukoliko TPV komplikuje osnovnu bolest, ona pogoršava njenu prognozu, a konkomitantno se leče obe. Iako se najčešće javlja u sklopu ciroze jetre, malignih bolesti abdominalnih organa i nekih hemopatija, postoji i idiopatska TPV, koja se definiše ekskluzijom svih poznatih uzroka TPV. U ovom radu je prikazan slučaj hronične idioptaske TPV., Portal vein thrombosis (PVT) is a rare disorder of splanchnic circulation, frequently caused by concomitant presence of local and/or systemic factors. When portal vein thrombosis complicates causative diseases, it will worsen their prognosis, and in such a case, the causative disease and PVT are treated concomitantly. Despite the fact that PVT frequently complicates liver cirrhosis, intraabdominal malignancies, and some hematological diseases, after all causes are excluded, one can define idiopathic portal vein thrombosis. In this study we have described the case of idiopathic chronical portal vein thrombosis.",
journal = "Medicinska istraživanja",
title = "Hronična idiopatska Tromboza portne vene - prikaz slučaja, Chronic idiopathic portal vein thrombosis: A case study",
volume = "50",
number = "2",
pages = "13-17",
doi = "10.5937/MedIst1602013M"
}

Mitrović, B., Gluvić, Z., Samardžić, V., Obradović, M. M., Lačković, M., Cvetković, Z., Pavlović, A.,& Isenović, E. R.. (2016). Hronična idiopatska Tromboza portne vene - prikaz slučaja. in Medicinska istraživanja, 50(2), 13-17.
https://doi.org/10.5937/MedIst1602013M

Mitrović B, Gluvić Z, Samardžić V, Obradović MM, Lačković M, Cvetković Z, Pavlović A, Isenović ER. Hronična idiopatska Tromboza portne vene - prikaz slučaja. in Medicinska istraživanja. 2016;50(2):13-17.
doi:10.5937/MedIst1602013M .

Mitrović, Bojan, Gluvić, Zoran, Samardžić, Vladimir, Obradović, Milan M., Lačković, Milena, Cvetković, Zorica, Pavlović, Aleksandar, Isenović, Esma R., "Hronična idiopatska Tromboza portne vene - prikaz slučaja" in Medicinska istraživanja, 50, no. 2 (2016):13-17,
https://doi.org/10.5937/MedIst1602013M . .

TY  - JOUR
AU  - Popin-Tarić, Marija
AU  - Gluvić, Zoran
AU  - Samardžić, Vladimir
AU  - Vasić-Vlaisavljević, Anita
AU  - Tica-Jevtić, Jelena
AU  - Panić, Anastasija
AU  - Sudar-Milovanović, Emina
AU  - Tomašević, Ratko
AU  - Isenović, Esma R.
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10313
AB  - Uvod: Poznat je uticaj manifestnih tireoidnih disfunkcija na promene u koštanoj masi koji se ispoljava kroz izmene u koštanom prometu, koje dovode do promena koštane gustine i mogućeg povećanog rizika od pada i preloma. Takođe, uticajem na metaboličke parametre, prevashodno na lipide, tireoidne disfunkcije predstavljaju važan uzrok akceleracije ateroskleroze i povećanja cerebrovaskularnog i kardiovaskularnog rizika. Ovom studijom je ispitivan metabolički profil i koštana gustina kod pacijenata sa dijagnostikovanom supkliničkom tireoidnom disfunkcijom. Materijal i metode: Pilot studija preseka obuhvatila je 45 selektovanih ispitanica, koje su ispunile inkluzione kriterijume. Na osnovu nivoa tireo-stimulišućeg hormona (TSH) i slobodnog tiroksina (fT4) ispitanice su svrstane u 3 grupe, po 15 ispitanica u svakoj grupi: -grupa: supklinička hipotireoza (SHipo), grupa: supklinička hipertireoza (SHiper), i grupa: eutireodna-tj. kontrolna grupa. Od faktora rizika, praćeni su godine života, podaci o menopauzi i prethodnim prelomima, a od metaboličkih parametara indeks telesne mase (engl. Body Mass Index, BMI), obim struka (OS), obim kuka (OK), nivo tri-glicerida i nivo ukupnog holesterola. Kod svih ispitanica je merena koštana gustina na lumbalnoj kičmi i levom kuku (LK) i izražena u T skorovima. Dobijeni podaci su analizirani koriščćenjem statističkog paketa SPSS za Windows. Statistički značajnom je smatrana verovatnoća manja od 0,05 (p<0,05). Rezultati: Grupe ispitanica su se značajno razlikovale po nivoima ukupnog holesterola, kao i T skorovima lumbalne kičme i LK. Smanjena koštana gustina je registrovana kod 35 (77,8%) ispitanica. Vrednosti T skorova lumbalne kičme i LK su unutargrupno međusobno korelisali. Od faktora rizika, postojanje prethodnih preloma i menopauze, značajno utiču na T skorove, što nije slučaj ni sa jednim metaboličkim parametrom. Najniži T skorovi, kao i sa kliničkog aspekta najznačajnija dislipidemija, su registrovani u grupi SHipo. Diskusija: U okviru ove pilot studije pokazano je smanjenje koštane gustine u populaciji ispitanica sa supkliničkim tireoidopatijama, najviše izražena u SHipo grupi. U istoj grupi je zabeležen i klinički najaterogeniji lipidni profil (hiperholesterolemija). Metabolički parametri kao i hormoni nisu uticali na T skorove lumbalne kičme i LK. Zaključak: Supkliničke tireoidne disfunkcije su povezane sa smanjenjem koštane gustine, izražene kroz T skorove na lumbalnoj kičmi i LK, i na njih nisu uticali metabolički parametri. Pravovremenom dijagnostikom i lečenjem tireoidnih disfunkcija, moguće je usporiti gubitak koštane mase, smanjiti rizik kako od pada tako i od preloma, pri čemu korekcijom lipidnog disbalansa se može smanjiti potencijalni cerebrovaskularni i kardiovaskularni rizik.
AB  - Introduction. It is well-known that overt thyroid dysfunctions have an influence on bone mineral density (BMD). It is noticed as a change in bone turnover and BMD, with subsequent increased risk of fall-induced fractures. Additionally, promoting the lipid profile derangement, subclinical thyroid dysfunction seems to be an important factor of atherosclerosis acceleration and the risk of cerebrovascular and cardiovascular incidents. In this study we examined the relationship between some of osteoporosis risk factors, metabolic parameters and BMD, in subclinical thyroidopathies. Material and Methods. Pilot cross-sectional study involved 45 females selected on fulfilled inclusion criteria. Three groups of 15 examinees were formed, based on TSH and fT4 serum levels (SHypo, SHyper, and euthyroid-control). As for risk factors, age, records on menopause and history of past fractures as well as metabolic parameters Body Mass Index (BMI), waist and hip circumference, cholesterol and triglyceride levels were observed. The entire study population was referred to DEXA (Dual Energy X Ray Absorptiometry) scan for BMD measurement on lumbar spine (LS) and left hip (LH), expressed through T scores. The obtained data were analyzed by SPSS for Windows 18.0 statistical package. The level of statistical significance was 0.05. Results. The groups of patients differed on cholesterol levels and LS/LH T scores. Decreased BMD was detected in 35 (77.4%) patients. Intergroup correlations of LS/LH T scores were registered. A history of past fractures and records on menopause significantly influenced LS/LH T scores, which was not the case with metabolic parameters. Both the lowest T scores and clinically important dyslipidemia were presented in SHypo group. Discussion. The pilot study pointed out a decrease in BMD (mostly on osteopenia level) in subclinical, presumably hypothyroid disorder. The presence of hypercholesterolemia was detected in the same group. Metabolic parameters and thyroid hormones (TSH and fT4) did not have an effect on BMD. Conclusion. Subclinical thyroid dysfunctions are associated with a decrease in BMD, mostly presented as osteopenia, with a higher degree of severity in SHypo group. There is no registered influence of metabolic parameters on LS/LH T scores. It can be possible to slow down progression of decrease in BMD and subsequent fracture risk, with proper diagnostics and management of subclinical thyroid dysfunctions. Additionally, with correction of lipid disorders, cardiovascular and cerebrovascular risk could be minimized.
T2  - Medicinska istraživanja
T1  - Korelacija metaboličkog profila i koštane gustine kod netretiranih ispitanica obolelih od supkliničkih tireoidnih disfunkcija - pilot studija
T1  - Correlation of metabolic profile and Bone mineral density in treatment: Naive females with subclinical thyroid dysfunction: A pilot study
VL  - 49
IS  - 2
SP  - 50
EP  - 57
DO  - 10.5937/MedIst1502050P
ER  - 

@article{
author = "Popin-Tarić, Marija and Gluvić, Zoran and Samardžić, Vladimir and Vasić-Vlaisavljević, Anita and Tica-Jevtić, Jelena and Panić, Anastasija and Sudar-Milovanović, Emina and Tomašević, Ratko and Isenović, Esma R.",
year = "2015",
abstract = "Uvod: Poznat je uticaj manifestnih tireoidnih disfunkcija na promene u koštanoj masi koji se ispoljava kroz izmene u koštanom prometu, koje dovode do promena koštane gustine i mogućeg povećanog rizika od pada i preloma. Takođe, uticajem na metaboličke parametre, prevashodno na lipide, tireoidne disfunkcije predstavljaju važan uzrok akceleracije ateroskleroze i povećanja cerebrovaskularnog i kardiovaskularnog rizika. Ovom studijom je ispitivan metabolički profil i koštana gustina kod pacijenata sa dijagnostikovanom supkliničkom tireoidnom disfunkcijom. Materijal i metode: Pilot studija preseka obuhvatila je 45 selektovanih ispitanica, koje su ispunile inkluzione kriterijume. Na osnovu nivoa tireo-stimulišućeg hormona (TSH) i slobodnog tiroksina (fT4) ispitanice su svrstane u 3 grupe, po 15 ispitanica u svakoj grupi: -grupa: supklinička hipotireoza (SHipo), grupa: supklinička hipertireoza (SHiper), i grupa: eutireodna-tj. kontrolna grupa. Od faktora rizika, praćeni su godine života, podaci o menopauzi i prethodnim prelomima, a od metaboličkih parametara indeks telesne mase (engl. Body Mass Index, BMI), obim struka (OS), obim kuka (OK), nivo tri-glicerida i nivo ukupnog holesterola. Kod svih ispitanica je merena koštana gustina na lumbalnoj kičmi i levom kuku (LK) i izražena u T skorovima. Dobijeni podaci su analizirani koriščćenjem statističkog paketa SPSS za Windows. Statistički značajnom je smatrana verovatnoća manja od 0,05 (p<0,05). Rezultati: Grupe ispitanica su se značajno razlikovale po nivoima ukupnog holesterola, kao i T skorovima lumbalne kičme i LK. Smanjena koštana gustina je registrovana kod 35 (77,8%) ispitanica. Vrednosti T skorova lumbalne kičme i LK su unutargrupno međusobno korelisali. Od faktora rizika, postojanje prethodnih preloma i menopauze, značajno utiču na T skorove, što nije slučaj ni sa jednim metaboličkim parametrom. Najniži T skorovi, kao i sa kliničkog aspekta najznačajnija dislipidemija, su registrovani u grupi SHipo. Diskusija: U okviru ove pilot studije pokazano je smanjenje koštane gustine u populaciji ispitanica sa supkliničkim tireoidopatijama, najviše izražena u SHipo grupi. U istoj grupi je zabeležen i klinički najaterogeniji lipidni profil (hiperholesterolemija). Metabolički parametri kao i hormoni nisu uticali na T skorove lumbalne kičme i LK. Zaključak: Supkliničke tireoidne disfunkcije su povezane sa smanjenjem koštane gustine, izražene kroz T skorove na lumbalnoj kičmi i LK, i na njih nisu uticali metabolički parametri. Pravovremenom dijagnostikom i lečenjem tireoidnih disfunkcija, moguće je usporiti gubitak koštane mase, smanjiti rizik kako od pada tako i od preloma, pri čemu korekcijom lipidnog disbalansa se može smanjiti potencijalni cerebrovaskularni i kardiovaskularni rizik., Introduction. It is well-known that overt thyroid dysfunctions have an influence on bone mineral density (BMD). It is noticed as a change in bone turnover and BMD, with subsequent increased risk of fall-induced fractures. Additionally, promoting the lipid profile derangement, subclinical thyroid dysfunction seems to be an important factor of atherosclerosis acceleration and the risk of cerebrovascular and cardiovascular incidents. In this study we examined the relationship between some of osteoporosis risk factors, metabolic parameters and BMD, in subclinical thyroidopathies. Material and Methods. Pilot cross-sectional study involved 45 females selected on fulfilled inclusion criteria. Three groups of 15 examinees were formed, based on TSH and fT4 serum levels (SHypo, SHyper, and euthyroid-control). As for risk factors, age, records on menopause and history of past fractures as well as metabolic parameters Body Mass Index (BMI), waist and hip circumference, cholesterol and triglyceride levels were observed. The entire study population was referred to DEXA (Dual Energy X Ray Absorptiometry) scan for BMD measurement on lumbar spine (LS) and left hip (LH), expressed through T scores. The obtained data were analyzed by SPSS for Windows 18.0 statistical package. The level of statistical significance was 0.05. Results. The groups of patients differed on cholesterol levels and LS/LH T scores. Decreased BMD was detected in 35 (77.4%) patients. Intergroup correlations of LS/LH T scores were registered. A history of past fractures and records on menopause significantly influenced LS/LH T scores, which was not the case with metabolic parameters. Both the lowest T scores and clinically important dyslipidemia were presented in SHypo group. Discussion. The pilot study pointed out a decrease in BMD (mostly on osteopenia level) in subclinical, presumably hypothyroid disorder. The presence of hypercholesterolemia was detected in the same group. Metabolic parameters and thyroid hormones (TSH and fT4) did not have an effect on BMD. Conclusion. Subclinical thyroid dysfunctions are associated with a decrease in BMD, mostly presented as osteopenia, with a higher degree of severity in SHypo group. There is no registered influence of metabolic parameters on LS/LH T scores. It can be possible to slow down progression of decrease in BMD and subsequent fracture risk, with proper diagnostics and management of subclinical thyroid dysfunctions. Additionally, with correction of lipid disorders, cardiovascular and cerebrovascular risk could be minimized.",
journal = "Medicinska istraživanja",
title = "Korelacija metaboličkog profila i koštane gustine kod netretiranih ispitanica obolelih od supkliničkih tireoidnih disfunkcija - pilot studija, Correlation of metabolic profile and Bone mineral density in treatment: Naive females with subclinical thyroid dysfunction: A pilot study",
volume = "49",
number = "2",
pages = "50-57",
doi = "10.5937/MedIst1502050P"
}

Popin-Tarić, M., Gluvić, Z., Samardžić, V., Vasić-Vlaisavljević, A., Tica-Jevtić, J., Panić, A., Sudar-Milovanović, E., Tomašević, R.,& Isenović, E. R.. (2015). Korelacija metaboličkog profila i koštane gustine kod netretiranih ispitanica obolelih od supkliničkih tireoidnih disfunkcija - pilot studija. in Medicinska istraživanja, 49(2), 50-57.
https://doi.org/10.5937/MedIst1502050P

Popin-Tarić M, Gluvić Z, Samardžić V, Vasić-Vlaisavljević A, Tica-Jevtić J, Panić A, Sudar-Milovanović E, Tomašević R, Isenović ER. Korelacija metaboličkog profila i koštane gustine kod netretiranih ispitanica obolelih od supkliničkih tireoidnih disfunkcija - pilot studija. in Medicinska istraživanja. 2015;49(2):50-57.
doi:10.5937/MedIst1502050P .

Popin-Tarić, Marija, Gluvić, Zoran, Samardžić, Vladimir, Vasić-Vlaisavljević, Anita, Tica-Jevtić, Jelena, Panić, Anastasija, Sudar-Milovanović, Emina, Tomašević, Ratko, Isenović, Esma R., "Korelacija metaboličkog profila i koštane gustine kod netretiranih ispitanica obolelih od supkliničkih tireoidnih disfunkcija - pilot studija" in Medicinska istraživanja, 49, no. 2 (2015):50-57,
https://doi.org/10.5937/MedIst1502050P . .

TY  - JOUR
AU  - Gluvić, Zoran
AU  - Kovačević, Pejka
AU  - Obradović, Milan M.
AU  - Trebaljevac, Jovana
AU  - Samardžić, Vladimir
AU  - Lačković, Milena
AU  - Isenović, Esma R.
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10152
AB  - Akutni infarkt miokarda (AIM) je klinički oblik koronarne bolesti srca, koji nastaje pri okluziji koronarne arterije, a ireverzibilna ishemija progredira do nekroze miokarda. Morbiditet i mortalitet od kardiovaskularnih komorbiditeta, uključujući AIM, je kod obolelih od insulin-nezavisnog dijabetesa veći nego kod nedijabetičara iste životne dobi. Jedan od razloga za veći mortalitet od infarkta miokarda kod dijabetičara može biti i srčana insuficijencija. Bolesnici sa diajbetesom i AIM imaju povećan rizik od lošeg ishoda terapije AIM u odnosu na nedijabetičare, a osnovni razlozi su endotelna disfunkcija, protrombotično stanje, veća mogućnost restenoze, negativnog vaskularnog remodelovanja, povećane glikolizacije proteinai depozicije vaskularnog matriksa. U okviru ovog preglednog članka, dat je prikaz najnovijih literaturnih podataka i praktičnih saznanja o AIM kod dijabetičnih bolesnika.
AB  - Acute myocardial infarction (AMI) is a clinical form of coronary heart disease, which occurs after coronary arteries' occlusion and irreversible ischemia progression leads to myocardial necrosis. Morbidity and mortality caused by cardiovascular comorbidities, including AIM, are greater in patients with insulin - dependent diabetes than in non - diabetes patients of the same age. One of the reasons for a higher mortality rate from AMI in patients with diabetes may be heart failure. In addition, patients with diabetes and AMI have an increased risk for poor therapy outcomes of AMI compared with non - diabetes patients, and the main reasons are endothelial dysfunction, prothrombotic state, a greater possibility of restenosis, negative vascular remodelling, increased protein glycosylation, and vascular matrix deposition. In this review, we provide an overview of recent literature data and practical knowledge related to the AMI in diabetic patients.
T2  - Medicinska istraživanja
T1  - Akutni infarkt miokarda i diabetes mellitus
T1  - Acute myocardial infarction and diabetes mellitus
VL  - 49
IS  - 3
SP  - 16
EP  - 19
DO  - 10.5937/MedIst1503016G
ER  - 

@article{
author = "Gluvić, Zoran and Kovačević, Pejka and Obradović, Milan M. and Trebaljevac, Jovana and Samardžić, Vladimir and Lačković, Milena and Isenović, Esma R.",
year = "2015",
abstract = "Akutni infarkt miokarda (AIM) je klinički oblik koronarne bolesti srca, koji nastaje pri okluziji koronarne arterije, a ireverzibilna ishemija progredira do nekroze miokarda. Morbiditet i mortalitet od kardiovaskularnih komorbiditeta, uključujući AIM, je kod obolelih od insulin-nezavisnog dijabetesa veći nego kod nedijabetičara iste životne dobi. Jedan od razloga za veći mortalitet od infarkta miokarda kod dijabetičara može biti i srčana insuficijencija. Bolesnici sa diajbetesom i AIM imaju povećan rizik od lošeg ishoda terapije AIM u odnosu na nedijabetičare, a osnovni razlozi su endotelna disfunkcija, protrombotično stanje, veća mogućnost restenoze, negativnog vaskularnog remodelovanja, povećane glikolizacije proteinai depozicije vaskularnog matriksa. U okviru ovog preglednog članka, dat je prikaz najnovijih literaturnih podataka i praktičnih saznanja o AIM kod dijabetičnih bolesnika., Acute myocardial infarction (AMI) is a clinical form of coronary heart disease, which occurs after coronary arteries' occlusion and irreversible ischemia progression leads to myocardial necrosis. Morbidity and mortality caused by cardiovascular comorbidities, including AIM, are greater in patients with insulin - dependent diabetes than in non - diabetes patients of the same age. One of the reasons for a higher mortality rate from AMI in patients with diabetes may be heart failure. In addition, patients with diabetes and AMI have an increased risk for poor therapy outcomes of AMI compared with non - diabetes patients, and the main reasons are endothelial dysfunction, prothrombotic state, a greater possibility of restenosis, negative vascular remodelling, increased protein glycosylation, and vascular matrix deposition. In this review, we provide an overview of recent literature data and practical knowledge related to the AMI in diabetic patients.",
journal = "Medicinska istraživanja",
title = "Akutni infarkt miokarda i diabetes mellitus, Acute myocardial infarction and diabetes mellitus",
volume = "49",
number = "3",
pages = "16-19",
doi = "10.5937/MedIst1503016G"
}

Gluvić, Z., Kovačević, P., Obradović, M. M., Trebaljevac, J., Samardžić, V., Lačković, M.,& Isenović, E. R.. (2015). Akutni infarkt miokarda i diabetes mellitus. in Medicinska istraživanja, 49(3), 16-19.
https://doi.org/10.5937/MedIst1503016G

Gluvić Z, Kovačević P, Obradović MM, Trebaljevac J, Samardžić V, Lačković M, Isenović ER. Akutni infarkt miokarda i diabetes mellitus. in Medicinska istraživanja. 2015;49(3):16-19.
doi:10.5937/MedIst1503016G .

Gluvić, Zoran, Kovačević, Pejka, Obradović, Milan M., Trebaljevac, Jovana, Samardžić, Vladimir, Lačković, Milena, Isenović, Esma R., "Akutni infarkt miokarda i diabetes mellitus" in Medicinska istraživanja, 49, no. 3 (2015):16-19,
https://doi.org/10.5937/MedIst1503016G . .