TY  - CONF
AU  - Drljača, Tamara
AU  - Stevanović, Kristina
AU  - Radošević, Draginja
AU  - Milićević, Jelena S.
AU  - Veljković, Nevena
AU  - Glišić, Sanja
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12243
AB  - Peroxisome proliferator-activated receptor alpha (PPARα) is crucial in regulating lipid metabolism. Clinically, PPARα is significant as a possible therapeutic target for a variety of human disorders, including cardiovascular, neurological, and metabolic syndromes. The wide range of natural compounds provides great opportunities for new approaches in targeting PPARα. Carotenoids, a large class of natural compounds, have been recognized as PPARα agonists. Tomatoes (Solanum lycopersicum) are one of the most widely grown crops in the world and contain compounds that improve lipid metabolism. Since there is no data on tomato carotenoids as PPARα agonists in this study, we focused on searching carotenoids from tomatoes as possible PPARα agonists. The Solanum lycopersicum carotenoids from Carotenoids Database were in silico screened using a combined protocol with the Electron-Ion Interaction Potential/Average Quasi Valence Number (EIIP/AQVN) filter and molecular docking to find the most promising candidate compounds. The best resulting compounds may have the promise to be further developed as candidates for PPARα agonists.
PB  - Kragujevac : Institute for Information Technologies, University of Kragujevac
C3  - ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings
T1  - In silico screening of Solanum lycopersicum carotenoids from Carotenoids Database for candidates PPARα agonists
SP  - 605
EP  - 608
DO  - 10.46793/ICCBI23.605D
ER  - 

@conference{
author = "Drljača, Tamara and Stevanović, Kristina and Radošević, Draginja and Milićević, Jelena S. and Veljković, Nevena and Glišić, Sanja",
year = "2023",
abstract = "Peroxisome proliferator-activated receptor alpha (PPARα) is crucial in regulating lipid metabolism. Clinically, PPARα is significant as a possible therapeutic target for a variety of human disorders, including cardiovascular, neurological, and metabolic syndromes. The wide range of natural compounds provides great opportunities for new approaches in targeting PPARα. Carotenoids, a large class of natural compounds, have been recognized as PPARα agonists. Tomatoes (Solanum lycopersicum) are one of the most widely grown crops in the world and contain compounds that improve lipid metabolism. Since there is no data on tomato carotenoids as PPARα agonists in this study, we focused on searching carotenoids from tomatoes as possible PPARα agonists. The Solanum lycopersicum carotenoids from Carotenoids Database were in silico screened using a combined protocol with the Electron-Ion Interaction Potential/Average Quasi Valence Number (EIIP/AQVN) filter and molecular docking to find the most promising candidate compounds. The best resulting compounds may have the promise to be further developed as candidates for PPARα agonists.",
publisher = "Kragujevac : Institute for Information Technologies, University of Kragujevac",
journal = "ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings",
title = "In silico screening of Solanum lycopersicum carotenoids from Carotenoids Database for candidates PPARα agonists",
pages = "605-608",
doi = "10.46793/ICCBI23.605D"
}

Drljača, T., Stevanović, K., Radošević, D., Milićević, J. S., Veljković, N.,& Glišić, S.. (2023). In silico screening of Solanum lycopersicum carotenoids from Carotenoids Database for candidates PPARα agonists. in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings
Kragujevac : Institute for Information Technologies, University of Kragujevac., 605-608.
https://doi.org/10.46793/ICCBI23.605D

Drljača T, Stevanović K, Radošević D, Milićević JS, Veljković N, Glišić S. In silico screening of Solanum lycopersicum carotenoids from Carotenoids Database for candidates PPARα agonists. in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings. 2023;:605-608.
doi:10.46793/ICCBI23.605D .

Drljača, Tamara, Stevanović, Kristina, Radošević, Draginja, Milićević, Jelena S., Veljković, Nevena, Glišić, Sanja, "In silico screening of Solanum lycopersicum carotenoids from Carotenoids Database for candidates PPARα agonists" in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings (2023):605-608,
https://doi.org/10.46793/ICCBI23.605D . .