TY  - JOUR
AU  - Đurašević, Siniša
AU  - Ružičić, Aleksandra
AU  - Lakić, Iva
AU  - Tosti, Tomislav
AU  - Đurović, Saša
AU  - Glumac, Sofija
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Drakulić, Dunja R.
AU  - Stanković, Sanja
AU  - Jasnić, Nebojša
AU  - Đorđević, Jelena
AU  - Todorović, Zoran
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10173
AB  - A dysregulated and overwhelming response to an infection accompanied by the exaggerated pro-inflammatory state and metabolism disturbance leads to the fatal outcome in sepsis. Previously we showed that meldonium, an anti-ischemic drug clinically used to treat myocardial and cerebral ischemia, strongly increases mortality in faecal-induced peritonitis (FIP) in rats. We postulated that the same mechanism that is responsible for the otherwise strong anti-inflammatory effects of meldonium could be the culprit of the increased mortality. In the present study, we applied the LPS-induced model of sepsis to explore the presence of any differences from and/or similarities to the FIP model. When it comes to energy production, despite some shared similarities, it is evident that LPS and FIP models of sepsis differ greatly. A different profile of sympathoadrenal activation may account for this observation, as it was lacking in the FIP model, whereas in the LPS model it was strong enough to overcome the effects of meldonium. Therefore, choosing the appropriate model of sepsis induction is of great importance, especially if energy homeostasis is the main focus of the study. Even when differences in the experimental design of the two models are acknowledged, the role of different patterns of energy production cannot be excluded. On that account, our results draw attention to the importance of uninterrupted energy production in sepsis but also call for much-needed revisions of the current recommendations for its treatment.
T2  - International Journal of Molecular Sciences
T1  - The Effects of a Meldonium Pre-Treatment on the Course of the LPS-Induced Sepsis in Rats
VL  - 23
IS  - 4
SP  - 2395
DO  - 10.3390/ijms23042395
ER  - 

@article{
author = "Đurašević, Siniša and Ružičić, Aleksandra and Lakić, Iva and Tosti, Tomislav and Đurović, Saša and Glumac, Sofija and Pejić, Snežana and Todorović, Ana and Drakulić, Dunja R. and Stanković, Sanja and Jasnić, Nebojša and Đorđević, Jelena and Todorović, Zoran",
year = "2022",
abstract = "A dysregulated and overwhelming response to an infection accompanied by the exaggerated pro-inflammatory state and metabolism disturbance leads to the fatal outcome in sepsis. Previously we showed that meldonium, an anti-ischemic drug clinically used to treat myocardial and cerebral ischemia, strongly increases mortality in faecal-induced peritonitis (FIP) in rats. We postulated that the same mechanism that is responsible for the otherwise strong anti-inflammatory effects of meldonium could be the culprit of the increased mortality. In the present study, we applied the LPS-induced model of sepsis to explore the presence of any differences from and/or similarities to the FIP model. When it comes to energy production, despite some shared similarities, it is evident that LPS and FIP models of sepsis differ greatly. A different profile of sympathoadrenal activation may account for this observation, as it was lacking in the FIP model, whereas in the LPS model it was strong enough to overcome the effects of meldonium. Therefore, choosing the appropriate model of sepsis induction is of great importance, especially if energy homeostasis is the main focus of the study. Even when differences in the experimental design of the two models are acknowledged, the role of different patterns of energy production cannot be excluded. On that account, our results draw attention to the importance of uninterrupted energy production in sepsis but also call for much-needed revisions of the current recommendations for its treatment.",
journal = "International Journal of Molecular Sciences",
title = "The Effects of a Meldonium Pre-Treatment on the Course of the LPS-Induced Sepsis in Rats",
volume = "23",
number = "4",
pages = "2395",
doi = "10.3390/ijms23042395"
}

Đurašević, S., Ružičić, A., Lakić, I., Tosti, T., Đurović, S., Glumac, S., Pejić, S., Todorović, A., Drakulić, D. R., Stanković, S., Jasnić, N., Đorđević, J.,& Todorović, Z.. (2022). The Effects of a Meldonium Pre-Treatment on the Course of the LPS-Induced Sepsis in Rats. in International Journal of Molecular Sciences, 23(4), 2395.
https://doi.org/10.3390/ijms23042395

Đurašević S, Ružičić A, Lakić I, Tosti T, Đurović S, Glumac S, Pejić S, Todorović A, Drakulić DR, Stanković S, Jasnić N, Đorđević J, Todorović Z. The Effects of a Meldonium Pre-Treatment on the Course of the LPS-Induced Sepsis in Rats. in International Journal of Molecular Sciences. 2022;23(4):2395.
doi:10.3390/ijms23042395 .

Đurašević, Siniša, Ružičić, Aleksandra, Lakić, Iva, Tosti, Tomislav, Đurović, Saša, Glumac, Sofija, Pejić, Snežana, Todorović, Ana, Drakulić, Dunja R., Stanković, Sanja, Jasnić, Nebojša, Đorđević, Jelena, Todorović, Zoran, "The Effects of a Meldonium Pre-Treatment on the Course of the LPS-Induced Sepsis in Rats" in International Journal of Molecular Sciences, 23, no. 4 (2022):2395,
https://doi.org/10.3390/ijms23042395 . .

TY  - JOUR
AU  - Waisi, Hadi
AU  - Janković, Bojan Ž.
AU  - Nikolić, Bogdan R.
AU  - Dragičević, Vesna
AU  - Panić, I.
AU  - Tosti, Tomislav B.
AU  - Trifković, Jelena Đ.
PY  - 2018
UR  - https://linkinghub.elsevier.com/retrieve/pii/S0254629918300814
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7863
AB  - 24-epibrassinolide (24-EBL) is plant steroid hormone that can regulate several physiological effects in plants, including promotion of cell growth and induction of heat stress tolerance. The purpose of this work is to investigate the influence of various concentrations of 24-EBL on the dehydration mechanism of seedlings of two maize hybrids (ZP434 and ZP704). Control and treated samples were subjected to isothermal conditions for dehydration processes. The effects of carbohydrates and mineral contents on the possible changes in the dehydration mechanism (from kinetics standpoint) were investigated. Comparing control samples to samples treated with 24-EBL, it was found that different dehydration mechanisms exist. The differences arise from the influence of 24-EBL, that causes a significant increase of phosphorus values for ZP704, whilst the reverse was identified for ZP434. It was assumed that the plumule sensitivity to dehydration stress originates from the interaction of water with primary amino groups as cations in polyamines, for lower concentrations of 24-EBL. It was found that the temperature variation (105–130 °C) leads to situations where trehalose does not arrive fast enough to “replace the water” because its handicap to binds (by hydrogen bonds) to biomolecules instead of water. It was found that 24-EBL cause changes of carbohydrates properties, which are important for the defense mechanism from environmental stresses. © 2018 SAAB
T2  - South African Journal of Botany
T1  - Influence of various concentrations of 24-epibrassinolide on the kinetic parameters during isothermal dehydration of two maize hybrids
VL  - 119
SP  - 69
EP  - 79
DO  - 10.1016/j.sajb.2018.08.006
ER  - 

@article{
author = "Waisi, Hadi and Janković, Bojan Ž. and Nikolić, Bogdan R. and Dragičević, Vesna and Panić, I. and Tosti, Tomislav B. and Trifković, Jelena Đ.",
year = "2018",
abstract = "24-epibrassinolide (24-EBL) is plant steroid hormone that can regulate several physiological effects in plants, including promotion of cell growth and induction of heat stress tolerance. The purpose of this work is to investigate the influence of various concentrations of 24-EBL on the dehydration mechanism of seedlings of two maize hybrids (ZP434 and ZP704). Control and treated samples were subjected to isothermal conditions for dehydration processes. The effects of carbohydrates and mineral contents on the possible changes in the dehydration mechanism (from kinetics standpoint) were investigated. Comparing control samples to samples treated with 24-EBL, it was found that different dehydration mechanisms exist. The differences arise from the influence of 24-EBL, that causes a significant increase of phosphorus values for ZP704, whilst the reverse was identified for ZP434. It was assumed that the plumule sensitivity to dehydration stress originates from the interaction of water with primary amino groups as cations in polyamines, for lower concentrations of 24-EBL. It was found that the temperature variation (105–130 °C) leads to situations where trehalose does not arrive fast enough to “replace the water” because its handicap to binds (by hydrogen bonds) to biomolecules instead of water. It was found that 24-EBL cause changes of carbohydrates properties, which are important for the defense mechanism from environmental stresses. © 2018 SAAB",
journal = "South African Journal of Botany",
title = "Influence of various concentrations of 24-epibrassinolide on the kinetic parameters during isothermal dehydration of two maize hybrids",
volume = "119",
pages = "69-79",
doi = "10.1016/j.sajb.2018.08.006"
}

Waisi, H., Janković, B. Ž., Nikolić, B. R., Dragičević, V., Panić, I., Tosti, T. B.,& Trifković, J. Đ.. (2018). Influence of various concentrations of 24-epibrassinolide on the kinetic parameters during isothermal dehydration of two maize hybrids. in South African Journal of Botany, 119, 69-79.
https://doi.org/10.1016/j.sajb.2018.08.006

Waisi H, Janković BŽ, Nikolić BR, Dragičević V, Panić I, Tosti TB, Trifković JĐ. Influence of various concentrations of 24-epibrassinolide on the kinetic parameters during isothermal dehydration of two maize hybrids. in South African Journal of Botany. 2018;119:69-79.
doi:10.1016/j.sajb.2018.08.006 .

Waisi, Hadi, Janković, Bojan Ž., Nikolić, Bogdan R., Dragičević, Vesna, Panić, I., Tosti, Tomislav B., Trifković, Jelena Đ., "Influence of various concentrations of 24-epibrassinolide on the kinetic parameters during isothermal dehydration of two maize hybrids" in South African Journal of Botany, 119 (2018):69-79,
https://doi.org/10.1016/j.sajb.2018.08.006 . .