TY  - JOUR
AU  - Milićević, Zorka T.
AU  - Bajić, Vladan P.
AU  - Živković, Lada
AU  - Kasapović, Jelena
AU  - Anđelković, Uros
AU  - Spremo-Potparević, Biljana
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5855
AB  - In breast carcinoma, disruption of the p53 pathway is one of the most common genetic alterations. The observation that the p53 can express multiple protein isoforms adds a novel level of complexity to the outcome of p53 mutations. p53 expression was analysed by Western immunoblotting and immunohistochemistry using monoclonal antibodies DO-7, Pab240, and polyclonal antiserum CM-1. The more frequently p53-positive nuclear staining has been found in the invasive breast tumors. One of the most intriguing findings is that mutant p53 appears as discrete dot-shaped regions within the nucleus of breast cancer cells. In many malignant cells, the nucleolar sequestration of p53 is evident. These observations support the view that the nucleolus is involved directly in the mediation of p53 function or indirectly by the control of the localization of p53 interplayers. p53 expressed in the nuclear fraction of breast cancer cells revealed a wide spectrum of isoforms. p53 isoforms Lambda Np53 (47 kDa) and Lambda 133p53 beta (35 kDa), known as dominant-negative repressors of p53 function, were detected as the most predominant variants in nuclei of invasive breast carcinoma cells. The isoforms expressed also varied between individual tumors, indicating potential roles of these p53 variants in human breast cancer.
T2  - Scientific World Journal
T1  - Identification of p53 and Its Isoforms in Human Breast Carcinoma Cells
DO  - 10.1155/2014/618698
ER  - 

@article{
author = "Milićević, Zorka T. and Bajić, Vladan P. and Živković, Lada and Kasapović, Jelena and Anđelković, Uros and Spremo-Potparević, Biljana",
year = "2014",
abstract = "In breast carcinoma, disruption of the p53 pathway is one of the most common genetic alterations. The observation that the p53 can express multiple protein isoforms adds a novel level of complexity to the outcome of p53 mutations. p53 expression was analysed by Western immunoblotting and immunohistochemistry using monoclonal antibodies DO-7, Pab240, and polyclonal antiserum CM-1. The more frequently p53-positive nuclear staining has been found in the invasive breast tumors. One of the most intriguing findings is that mutant p53 appears as discrete dot-shaped regions within the nucleus of breast cancer cells. In many malignant cells, the nucleolar sequestration of p53 is evident. These observations support the view that the nucleolus is involved directly in the mediation of p53 function or indirectly by the control of the localization of p53 interplayers. p53 expressed in the nuclear fraction of breast cancer cells revealed a wide spectrum of isoforms. p53 isoforms Lambda Np53 (47 kDa) and Lambda 133p53 beta (35 kDa), known as dominant-negative repressors of p53 function, were detected as the most predominant variants in nuclei of invasive breast carcinoma cells. The isoforms expressed also varied between individual tumors, indicating potential roles of these p53 variants in human breast cancer.",
journal = "Scientific World Journal",
title = "Identification of p53 and Its Isoforms in Human Breast Carcinoma Cells",
doi = "10.1155/2014/618698"
}

Milićević, Z. T., Bajić, V. P., Živković, L., Kasapović, J., Anđelković, U.,& Spremo-Potparević, B.. (2014). Identification of p53 and Its Isoforms in Human Breast Carcinoma Cells. in Scientific World Journal.
https://doi.org/10.1155/2014/618698

Milićević ZT, Bajić VP, Živković L, Kasapović J, Anđelković U, Spremo-Potparević B. Identification of p53 and Its Isoforms in Human Breast Carcinoma Cells. in Scientific World Journal. 2014;.
doi:10.1155/2014/618698 .

Milićević, Zorka T., Bajić, Vladan P., Živković, Lada, Kasapović, Jelena, Anđelković, Uros, Spremo-Potparević, Biljana, "Identification of p53 and Its Isoforms in Human Breast Carcinoma Cells" in Scientific World Journal (2014),
https://doi.org/10.1155/2014/618698 . .

TY  - JOUR
AU  - Milićević, Zorka T.
AU  - Kasapović, Jelena
AU  - Gavrilović, Ljubica
AU  - Milovanović, Zorka M.
AU  - Bajić, Vladan P.
AU  - Spremo-Potparević, Biljana
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/113
AB  - It is well recognized that cancers develop and grow as a result of disordered function of tumor suppressor genes and oncogenes, which may be exploited for screening purposes. Extensive evidence indicated tumor suppressor protein p53 as candidate marker for mutation identification. We have investigated mutant p53 protein expression in human breast tumors in relation to antioxidant status deficiency. The study included 100 breast cancer patients. p53 protein expression was evaluated by Western blot assay and immunostaining using a CM-1, DO-7 and Pab240 antibodies. Antioxidant parameters and lipid peroxidation were estimated by biochemical analyses. Western blotting with epitope-specific monoclonal antibody Pab240 strongly suggests that nuclear extracts from breast cancer cells express mutant forms of p53. It is of interest that the mutant forms of p53 overexpression in conjunction with the appearance of nuclear bodies are observed in highly aggressive carcinomas. Expression of isoform Delta p53 (45 kDa) and isoform of similar to 29 kDa were more common in cases with LN metastasis. These studies point out the molecular consequences of oxidative stress (lipid peroxides, LP, p LT 0.001) and antioxidant status deficiency (copper, zinc superoxid dismutase, SOD, p LT 0.001; catalase, CAT, p LT 0.01; glutathione reductase, GR, p LT 0.001; glutathione, GSH, p LT 0.05) and indicate the importance of p53 mutation as the commonest genetic alteration detected in breast cancer cells. The expression of mutant p53 is correlated to increased lipid peroxides (0.346, p LT 0.05) and lowered antioxidant activity of CAT (- 0.437, p LT 0.01) in the breast cancer patients.
T2  - EXCLI Journal
T1  - Mutant P53 Protein Expression and Antioxidant Status Deficiency in Breast Cancer
VL  - 13
SP  - 691
EP  - 708
UR  - https://hdl.handle.net/21.15107/rcub_vinar_113
ER  - 

@article{
author = "Milićević, Zorka T. and Kasapović, Jelena and Gavrilović, Ljubica and Milovanović, Zorka M. and Bajić, Vladan P. and Spremo-Potparević, Biljana",
year = "2014",
abstract = "It is well recognized that cancers develop and grow as a result of disordered function of tumor suppressor genes and oncogenes, which may be exploited for screening purposes. Extensive evidence indicated tumor suppressor protein p53 as candidate marker for mutation identification. We have investigated mutant p53 protein expression in human breast tumors in relation to antioxidant status deficiency. The study included 100 breast cancer patients. p53 protein expression was evaluated by Western blot assay and immunostaining using a CM-1, DO-7 and Pab240 antibodies. Antioxidant parameters and lipid peroxidation were estimated by biochemical analyses. Western blotting with epitope-specific monoclonal antibody Pab240 strongly suggests that nuclear extracts from breast cancer cells express mutant forms of p53. It is of interest that the mutant forms of p53 overexpression in conjunction with the appearance of nuclear bodies are observed in highly aggressive carcinomas. Expression of isoform Delta p53 (45 kDa) and isoform of similar to 29 kDa were more common in cases with LN metastasis. These studies point out the molecular consequences of oxidative stress (lipid peroxides, LP, p LT 0.001) and antioxidant status deficiency (copper, zinc superoxid dismutase, SOD, p LT 0.001; catalase, CAT, p LT 0.01; glutathione reductase, GR, p LT 0.001; glutathione, GSH, p LT 0.05) and indicate the importance of p53 mutation as the commonest genetic alteration detected in breast cancer cells. The expression of mutant p53 is correlated to increased lipid peroxides (0.346, p LT 0.05) and lowered antioxidant activity of CAT (- 0.437, p LT 0.01) in the breast cancer patients.",
journal = "EXCLI Journal",
title = "Mutant P53 Protein Expression and Antioxidant Status Deficiency in Breast Cancer",
volume = "13",
pages = "691-708",
url = "https://hdl.handle.net/21.15107/rcub_vinar_113"
}

Milićević, Z. T., Kasapović, J., Gavrilović, L., Milovanović, Z. M., Bajić, V. P.,& Spremo-Potparević, B.. (2014). Mutant P53 Protein Expression and Antioxidant Status Deficiency in Breast Cancer. in EXCLI Journal, 13, 691-708.
https://hdl.handle.net/21.15107/rcub_vinar_113

Milićević ZT, Kasapović J, Gavrilović L, Milovanović ZM, Bajić VP, Spremo-Potparević B. Mutant P53 Protein Expression and Antioxidant Status Deficiency in Breast Cancer. in EXCLI Journal. 2014;13:691-708.
https://hdl.handle.net/21.15107/rcub_vinar_113 .

Milićević, Zorka T., Kasapović, Jelena, Gavrilović, Ljubica, Milovanović, Zorka M., Bajić, Vladan P., Spremo-Potparević, Biljana, "Mutant P53 Protein Expression and Antioxidant Status Deficiency in Breast Cancer" in EXCLI Journal, 13 (2014):691-708,
https://hdl.handle.net/21.15107/rcub_vinar_113 .

TY  - JOUR
AU  - Gavrilović, Ljubica
AU  - Stojiljković, Vesna
AU  - Kasapović, Jelena
AU  - Popović, Nataša M.
AU  - Pajović, Snežana B.
AU  - Dronjak, Slađana
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5703
AB  - Chronic isolation of adult animals represents a form of psychological stress that produces sympatho-adrenomedullar activation. Exercise training acts as an important modulator of sympatho-adrenomedullary system. This study aimed to investigate physical exercise-related changes in gene expression of catecholamine biosynthetic enzymes (tyrosine hydroxylase, dopamine-beta-hydroxylase and phenylethanolamine N-methyltransferase) and cyclic adenosine monophosphate response element-binding (CREB) in the adrenal medulla, concentrations of catecholamines and corticosterone (CORT) in the plasma and the weight of adrenal glands of chronically psychosocially stressed adult rats exposed daily to 20 min treadmill running for 12 weeks, Also, we examined how additional acute immobilization stress changes the mentioned parameters. Treadmill running did not result in modulation of gene expression of catecholamine synthesizing enzymes and it decreased the level of CREB mRNA in the adrenal medulla of chronically psychosocially stressed adult rats. The potentially negative physiological adaptations after treadmill running were recorded as increased concentrations of catecholamines and decreased morning CORT concentration in the plasma, as well as the adrenal gland hypertrophy of chronically psychosocially stressed rats. The additional acute immobilization stress increases gene expression of catecholamine biosynthetic enzymes in the adrenal medulla, as well as catecholamines and CORT levels in the plasma. Treadmill exercise does not change the activity of sympatho-adrenomedullary system of chronically psychosocially stressed rats.
T2  - Anais de Academia Brasileira de Ciencias
T1  - Treadmill exercise does not change gene expression of adrenal catecholamine biosynthetic enzymes in chronically stressed rats
VL  - 85
IS  - 3
SP  - 999
EP  - 1012
DO  - 10.1590/S0001-37652013005000041
ER  - 

@article{
author = "Gavrilović, Ljubica and Stojiljković, Vesna and Kasapović, Jelena and Popović, Nataša M. and Pajović, Snežana B. and Dronjak, Slađana",
year = "2013",
abstract = "Chronic isolation of adult animals represents a form of psychological stress that produces sympatho-adrenomedullar activation. Exercise training acts as an important modulator of sympatho-adrenomedullary system. This study aimed to investigate physical exercise-related changes in gene expression of catecholamine biosynthetic enzymes (tyrosine hydroxylase, dopamine-beta-hydroxylase and phenylethanolamine N-methyltransferase) and cyclic adenosine monophosphate response element-binding (CREB) in the adrenal medulla, concentrations of catecholamines and corticosterone (CORT) in the plasma and the weight of adrenal glands of chronically psychosocially stressed adult rats exposed daily to 20 min treadmill running for 12 weeks, Also, we examined how additional acute immobilization stress changes the mentioned parameters. Treadmill running did not result in modulation of gene expression of catecholamine synthesizing enzymes and it decreased the level of CREB mRNA in the adrenal medulla of chronically psychosocially stressed adult rats. The potentially negative physiological adaptations after treadmill running were recorded as increased concentrations of catecholamines and decreased morning CORT concentration in the plasma, as well as the adrenal gland hypertrophy of chronically psychosocially stressed rats. The additional acute immobilization stress increases gene expression of catecholamine biosynthetic enzymes in the adrenal medulla, as well as catecholamines and CORT levels in the plasma. Treadmill exercise does not change the activity of sympatho-adrenomedullary system of chronically psychosocially stressed rats.",
journal = "Anais de Academia Brasileira de Ciencias",
title = "Treadmill exercise does not change gene expression of adrenal catecholamine biosynthetic enzymes in chronically stressed rats",
volume = "85",
number = "3",
pages = "999-1012",
doi = "10.1590/S0001-37652013005000041"
}

Gavrilović, L., Stojiljković, V., Kasapović, J., Popović, N. M., Pajović, S. B.,& Dronjak, S.. (2013). Treadmill exercise does not change gene expression of adrenal catecholamine biosynthetic enzymes in chronically stressed rats. in Anais de Academia Brasileira de Ciencias, 85(3), 999-1012.
https://doi.org/10.1590/S0001-37652013005000041

Gavrilović L, Stojiljković V, Kasapović J, Popović NM, Pajović SB, Dronjak S. Treadmill exercise does not change gene expression of adrenal catecholamine biosynthetic enzymes in chronically stressed rats. in Anais de Academia Brasileira de Ciencias. 2013;85(3):999-1012.
doi:10.1590/S0001-37652013005000041 .

Gavrilović, Ljubica, Stojiljković, Vesna, Kasapović, Jelena, Popović, Nataša M., Pajović, Snežana B., Dronjak, Slađana, "Treadmill exercise does not change gene expression of adrenal catecholamine biosynthetic enzymes in chronically stressed rats" in Anais de Academia Brasileira de Ciencias, 85, no. 3 (2013):999-1012,
https://doi.org/10.1590/S0001-37652013005000041 . .

TY  - JOUR
AU  - Pejić, Snežana
AU  - Kasapović, Jelena
AU  - Todorović, Ana
AU  - Stojiljković, Vesna
AU  - Gavrilović, Ljubica
AU  - Popović, Nataša M.
AU  - Pajović, Snežana B.
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5705
AB  - Objective: To investigate whether antioxidant enzyme activities (superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase) and lipid hydroperoxide levels in patients with endometrial polyps are influenced by the changes in sex hormones (estradiol, progesterone, FSH, and LH) during the menstrual cycle and in postmenopause. Study design: The material consisted of blood and endometrial tissue specimens from women diagnosed with endometrial polyps. Patients were divided into groups depending on the phase of the menstrual cycle - follicular or luteal - and the postmenopause. The activities of antioxidant enzymes and the lipid hydroperoxide levels were compared among the phases and a linear regression model was used to evaluate the associations between hormones and antioxidant/oxidant variables. Results: In the blood of examined women, a significant difference in superoxide dismutase activity and lipid hydroperoxide levels was recorded among the phases. There was also a positive correlation between the estradiol concentration and superoxide dismutase. In polyp tissue, we recorded a phase-related difference in superoxide dismutase and glutathione peroxidase activities as well as in the lipid hydroperoxide levels. A negative correlation was observed between FSH/LH and glutathione peroxidase, and between LH and superoxide dismutase. Conclusion: Antioxidant enzymes and lipid hydroperoxide levels in patients with endometrial polyps are influenced by the changes in sex hormones during the menstrual cycle and after the menopause, pointing to a role of the observed relationship in polyp etiology. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
T2  - European Journal of Obstetrics Gynecology and Reproductive Biology
T1  - Antioxidant enzymes in women with endometrial polyps: relation with sex hormones
VL  - 170
IS  - 1
SP  - 241
EP  - 246
DO  - 10.1016/j.ejogrb.2013.06.024
ER  - 

@article{
author = "Pejić, Snežana and Kasapović, Jelena and Todorović, Ana and Stojiljković, Vesna and Gavrilović, Ljubica and Popović, Nataša M. and Pajović, Snežana B.",
year = "2013",
abstract = "Objective: To investigate whether antioxidant enzyme activities (superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase) and lipid hydroperoxide levels in patients with endometrial polyps are influenced by the changes in sex hormones (estradiol, progesterone, FSH, and LH) during the menstrual cycle and in postmenopause. Study design: The material consisted of blood and endometrial tissue specimens from women diagnosed with endometrial polyps. Patients were divided into groups depending on the phase of the menstrual cycle - follicular or luteal - and the postmenopause. The activities of antioxidant enzymes and the lipid hydroperoxide levels were compared among the phases and a linear regression model was used to evaluate the associations between hormones and antioxidant/oxidant variables. Results: In the blood of examined women, a significant difference in superoxide dismutase activity and lipid hydroperoxide levels was recorded among the phases. There was also a positive correlation between the estradiol concentration and superoxide dismutase. In polyp tissue, we recorded a phase-related difference in superoxide dismutase and glutathione peroxidase activities as well as in the lipid hydroperoxide levels. A negative correlation was observed between FSH/LH and glutathione peroxidase, and between LH and superoxide dismutase. Conclusion: Antioxidant enzymes and lipid hydroperoxide levels in patients with endometrial polyps are influenced by the changes in sex hormones during the menstrual cycle and after the menopause, pointing to a role of the observed relationship in polyp etiology. (C) 2013 Elsevier Ireland Ltd. All rights reserved.",
journal = "European Journal of Obstetrics Gynecology and Reproductive Biology",
title = "Antioxidant enzymes in women with endometrial polyps: relation with sex hormones",
volume = "170",
number = "1",
pages = "241-246",
doi = "10.1016/j.ejogrb.2013.06.024"
}

Pejić, S., Kasapović, J., Todorović, A., Stojiljković, V., Gavrilović, L., Popović, N. M.,& Pajović, S. B.. (2013). Antioxidant enzymes in women with endometrial polyps: relation with sex hormones. in European Journal of Obstetrics Gynecology and Reproductive Biology, 170(1), 241-246.
https://doi.org/10.1016/j.ejogrb.2013.06.024

Pejić S, Kasapović J, Todorović A, Stojiljković V, Gavrilović L, Popović NM, Pajović SB. Antioxidant enzymes in women with endometrial polyps: relation with sex hormones. in European Journal of Obstetrics Gynecology and Reproductive Biology. 2013;170(1):241-246.
doi:10.1016/j.ejogrb.2013.06.024 .

Pejić, Snežana, Kasapović, Jelena, Todorović, Ana, Stojiljković, Vesna, Gavrilović, Ljubica, Popović, Nataša M., Pajović, Snežana B., "Antioxidant enzymes in women with endometrial polyps: relation with sex hormones" in European Journal of Obstetrics Gynecology and Reproductive Biology, 170, no. 1 (2013):241-246,
https://doi.org/10.1016/j.ejogrb.2013.06.024 . .

TY  - JOUR
AU  - Gavrilović, Ljubica
AU  - Stojiljković, Vesna
AU  - Kasapović, Jelena
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Pajović, Snežana B.
AU  - Dronjak, Slađana
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5189
AB  - The aim of this study was to examine how acute immobilization stress affects the concentrations of catecholamines in the plasma and the expression of the splenic catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) in chronically socially isolated rats. We found that acute immobilization increases the plasma catecholamine levels and splenic PNMT protein levels in chronically socially isolated rats. These results show that acute stress of chronically stressed animals activates the sympatho-adrenomedullary system and increases synthesis of splenic PNMT by 37%, both of which can modulate the immune function.
T2  - Archives of Biological Sciences
T1  - Effects of Acute Stress on Gene Expression of Splenic Catecholamine Biosynthetic Enzymes in Chronically Stressed Rats
VL  - 65
IS  - 1
SP  - 183
EP  - 189
DO  - 10.2298/ABS1301183G
ER  - 

@article{
author = "Gavrilović, Ljubica and Stojiljković, Vesna and Kasapović, Jelena and Pejić, Snežana and Todorović, Ana and Pajović, Snežana B. and Dronjak, Slađana",
year = "2013",
abstract = "The aim of this study was to examine how acute immobilization stress affects the concentrations of catecholamines in the plasma and the expression of the splenic catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) in chronically socially isolated rats. We found that acute immobilization increases the plasma catecholamine levels and splenic PNMT protein levels in chronically socially isolated rats. These results show that acute stress of chronically stressed animals activates the sympatho-adrenomedullary system and increases synthesis of splenic PNMT by 37%, both of which can modulate the immune function.",
journal = "Archives of Biological Sciences",
title = "Effects of Acute Stress on Gene Expression of Splenic Catecholamine Biosynthetic Enzymes in Chronically Stressed Rats",
volume = "65",
number = "1",
pages = "183-189",
doi = "10.2298/ABS1301183G"
}

Gavrilović, L., Stojiljković, V., Kasapović, J., Pejić, S., Todorović, A., Pajović, S. B.,& Dronjak, S.. (2013). Effects of Acute Stress on Gene Expression of Splenic Catecholamine Biosynthetic Enzymes in Chronically Stressed Rats. in Archives of Biological Sciences, 65(1), 183-189.
https://doi.org/10.2298/ABS1301183G

Gavrilović L, Stojiljković V, Kasapović J, Pejić S, Todorović A, Pajović SB, Dronjak S. Effects of Acute Stress on Gene Expression of Splenic Catecholamine Biosynthetic Enzymes in Chronically Stressed Rats. in Archives of Biological Sciences. 2013;65(1):183-189.
doi:10.2298/ABS1301183G .

Gavrilović, Ljubica, Stojiljković, Vesna, Kasapović, Jelena, Pejić, Snežana, Todorović, Ana, Pajović, Snežana B., Dronjak, Slađana, "Effects of Acute Stress on Gene Expression of Splenic Catecholamine Biosynthetic Enzymes in Chronically Stressed Rats" in Archives of Biological Sciences, 65, no. 1 (2013):183-189,
https://doi.org/10.2298/ABS1301183G . .

TY  - JOUR
AU  - Kasapović, Jelena
AU  - Stojiljković, Vesna
AU  - Gavrilović, Ljubica
AU  - Popović, Nataša M.
AU  - Milićević, Zorka T.
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4959
AB  - Reactive oxygen species (ROS) are independently recognized to play a significant role in radiation-induced damage on healthy tissue and in aging process. However, an age-related alteration of antioxidant (AO) system in radiation response in humans is poorly investigated. The aim of this paper was to evaluate the irradiation effects on the activities and expression of AO system in the blood of healthy women during aging. Blood samples were irradiated with curative and palliative doses of 2Gy or 9Gy gamma-rays. AO capacity for detoxification of O-2 center dot(-) and H2O2 in response to 2Gy gamma-irradiation decreases in women above 58 years, while in response to 9Gy shows signs of weakening after 45 years of age. Due to reduction of AO capacity during aging, cytotoxic effects of curative and palliative doses of irradiation, mediated by ROS, may significantly increase in older subjects, while removal of H2O2 excess could reduce them.
T2  - Scientific World Journal
T1  - Antioxidant Protection against Curative and Palliative Doses of Ionizing Irradiation in Human Blood Decreases with Aging
DO  - 10.1100/2012/982594
ER  - 

@article{
author = "Kasapović, Jelena and Stojiljković, Vesna and Gavrilović, Ljubica and Popović, Nataša M. and Milićević, Zorka T.",
year = "2012",
abstract = "Reactive oxygen species (ROS) are independently recognized to play a significant role in radiation-induced damage on healthy tissue and in aging process. However, an age-related alteration of antioxidant (AO) system in radiation response in humans is poorly investigated. The aim of this paper was to evaluate the irradiation effects on the activities and expression of AO system in the blood of healthy women during aging. Blood samples were irradiated with curative and palliative doses of 2Gy or 9Gy gamma-rays. AO capacity for detoxification of O-2 center dot(-) and H2O2 in response to 2Gy gamma-irradiation decreases in women above 58 years, while in response to 9Gy shows signs of weakening after 45 years of age. Due to reduction of AO capacity during aging, cytotoxic effects of curative and palliative doses of irradiation, mediated by ROS, may significantly increase in older subjects, while removal of H2O2 excess could reduce them.",
journal = "Scientific World Journal",
title = "Antioxidant Protection against Curative and Palliative Doses of Ionizing Irradiation in Human Blood Decreases with Aging",
doi = "10.1100/2012/982594"
}

Kasapović, J., Stojiljković, V., Gavrilović, L., Popović, N. M.,& Milićević, Z. T.. (2012). Antioxidant Protection against Curative and Palliative Doses of Ionizing Irradiation in Human Blood Decreases with Aging. in Scientific World Journal.
https://doi.org/10.1100/2012/982594

Kasapović J, Stojiljković V, Gavrilović L, Popović NM, Milićević ZT. Antioxidant Protection against Curative and Palliative Doses of Ionizing Irradiation in Human Blood Decreases with Aging. in Scientific World Journal. 2012;.
doi:10.1100/2012/982594 .

Kasapović, Jelena, Stojiljković, Vesna, Gavrilović, Ljubica, Popović, Nataša M., Milićević, Zorka T., "Antioxidant Protection against Curative and Palliative Doses of Ionizing Irradiation in Human Blood Decreases with Aging" in Scientific World Journal (2012),
https://doi.org/10.1100/2012/982594 . .

TY  - JOUR
AU  - Gavrilović, Ljubica
AU  - Stojiljković, Vesna
AU  - Kasapović, Jelena
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Pajović, Snežana B.
AU  - Dronjak, Slađana
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4915
AB  - In this study we examined how chronic forced running (CFR) affects the expression of catecholamine biosynthetic enzymes and cAMP response element-binding (CREB) in the adrenal medulla and the weight of adrenal glands of rats. Also, we examined how CFR and additional acute immobilization stress affect the expression of catecholamine biosynthetic enzymes in the adrenal medulla and the concentration of catecholamines and corticosterone (CORT) in the blood plasma. In this experiment we used as a model forced exercise in rats (treadmill running). We used the most advanced method for determining the level of gene expression, Real-time PCR with TaqMan probes, as well as Western blot analysis (ECL). We found that CFR decreases tyrosine hydroxylase (TH), and dopamine-beta-hydroxylase (DBH) mRNA and protein levels in the adrenal medulla. The decreased TH and DBH mRNA levels coincide with the reduced expression of CREB in the adrenal medulla and with the reduced plasma CORT level. Additionally, CFR reduces the level of phenylethanolamine N-methyltransferase (PNMT) mRNA, but elevates its protein level in the adrenal medulla and increases the concentration of adrenaline (A) in the plasma. Reduced level of PNMT mRNA in the adrenal medulla coincides with reduced plasma CORT level. The additional acute immobilization stress increases gene expression of catecholamine biosynthetic enzymes in the adrenal medulla, as well as catecholamines and CORT levels in the plasma. The increased synthesis of PNMT enzyme in the adrenal medulla may result in an increased biosynthesis of A under chronic stress conditions. Additionally, increased level of catecholamines in the plasma after chronic physical stress is the allostatic load that may induce numerous diseases and pathological conditions.
T2  - Acta Veterinaria, Beograd
T1  - Chronic Physical Stress Changes Gene Expression of Catecholamine Biosynthetic Enzymes in the Adrenal Medulla of Adult Rats
VL  - 62
IS  - 2-3
SP  - 151
EP  - 169
DO  - 10.2298/AVB1203151G
ER  - 

@article{
author = "Gavrilović, Ljubica and Stojiljković, Vesna and Kasapović, Jelena and Pejić, Snežana and Todorović, Ana and Pajović, Snežana B. and Dronjak, Slađana",
year = "2012",
abstract = "In this study we examined how chronic forced running (CFR) affects the expression of catecholamine biosynthetic enzymes and cAMP response element-binding (CREB) in the adrenal medulla and the weight of adrenal glands of rats. Also, we examined how CFR and additional acute immobilization stress affect the expression of catecholamine biosynthetic enzymes in the adrenal medulla and the concentration of catecholamines and corticosterone (CORT) in the blood plasma. In this experiment we used as a model forced exercise in rats (treadmill running). We used the most advanced method for determining the level of gene expression, Real-time PCR with TaqMan probes, as well as Western blot analysis (ECL). We found that CFR decreases tyrosine hydroxylase (TH), and dopamine-beta-hydroxylase (DBH) mRNA and protein levels in the adrenal medulla. The decreased TH and DBH mRNA levels coincide with the reduced expression of CREB in the adrenal medulla and with the reduced plasma CORT level. Additionally, CFR reduces the level of phenylethanolamine N-methyltransferase (PNMT) mRNA, but elevates its protein level in the adrenal medulla and increases the concentration of adrenaline (A) in the plasma. Reduced level of PNMT mRNA in the adrenal medulla coincides with reduced plasma CORT level. The additional acute immobilization stress increases gene expression of catecholamine biosynthetic enzymes in the adrenal medulla, as well as catecholamines and CORT levels in the plasma. The increased synthesis of PNMT enzyme in the adrenal medulla may result in an increased biosynthesis of A under chronic stress conditions. Additionally, increased level of catecholamines in the plasma after chronic physical stress is the allostatic load that may induce numerous diseases and pathological conditions.",
journal = "Acta Veterinaria, Beograd",
title = "Chronic Physical Stress Changes Gene Expression of Catecholamine Biosynthetic Enzymes in the Adrenal Medulla of Adult Rats",
volume = "62",
number = "2-3",
pages = "151-169",
doi = "10.2298/AVB1203151G"
}

Gavrilović, L., Stojiljković, V., Kasapović, J., Pejić, S., Todorović, A., Pajović, S. B.,& Dronjak, S.. (2012). Chronic Physical Stress Changes Gene Expression of Catecholamine Biosynthetic Enzymes in the Adrenal Medulla of Adult Rats. in Acta Veterinaria, Beograd, 62(2-3), 151-169.
https://doi.org/10.2298/AVB1203151G

Gavrilović L, Stojiljković V, Kasapović J, Pejić S, Todorović A, Pajović SB, Dronjak S. Chronic Physical Stress Changes Gene Expression of Catecholamine Biosynthetic Enzymes in the Adrenal Medulla of Adult Rats. in Acta Veterinaria, Beograd. 2012;62(2-3):151-169.
doi:10.2298/AVB1203151G .

Gavrilović, Ljubica, Stojiljković, Vesna, Kasapović, Jelena, Pejić, Snežana, Todorović, Ana, Pajović, Snežana B., Dronjak, Slađana, "Chronic Physical Stress Changes Gene Expression of Catecholamine Biosynthetic Enzymes in the Adrenal Medulla of Adult Rats" in Acta Veterinaria, Beograd, 62, no. 2-3 (2012):151-169,
https://doi.org/10.2298/AVB1203151G . .

TY  - JOUR
AU  - Gavrilović, Ljubica
AU  - Stojiljković, Vesna
AU  - Kasapović, Jelena
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Pajović, Snežana B.
AU  - Dronjak, Slađana
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5057
AB  - Treadmill training produces modulation of neuro-endocrine and immune functions. This study examined the effects of chronic forced running (CFR) on the plasma concentration of catecholamines and the expression of splenic catecholamine biosynthetic enzymes in rats by using real-time RT-PCR and Western blot analyses. We found that CFR increases the plasma catecholamine levels, decreases splenic tyrosine hydroxylase (TH), dopamine-p-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) mRNA levels and increases splenic PNMT protein levels. This shows that CFR is a very strong stressor which activates the sympatho-adrenomedullary system and increases synthesis of splenic PNMT by 20%, which both can modulate the immune function. (C) 2012 Elsevier B.V. All rights reserved.
T2  - Journal of Neuroimmunology
T1  - Forced exercise changes catecholamine synthesis in the spleen of adult rats
VL  - 251
IS  - 1-2
SP  - 1
EP  - 5
DO  - 10.1016/j.jneuroim.2012.06.002
ER  - 

@article{
author = "Gavrilović, Ljubica and Stojiljković, Vesna and Kasapović, Jelena and Pejić, Snežana and Todorović, Ana and Pajović, Snežana B. and Dronjak, Slađana",
year = "2012",
abstract = "Treadmill training produces modulation of neuro-endocrine and immune functions. This study examined the effects of chronic forced running (CFR) on the plasma concentration of catecholamines and the expression of splenic catecholamine biosynthetic enzymes in rats by using real-time RT-PCR and Western blot analyses. We found that CFR increases the plasma catecholamine levels, decreases splenic tyrosine hydroxylase (TH), dopamine-p-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) mRNA levels and increases splenic PNMT protein levels. This shows that CFR is a very strong stressor which activates the sympatho-adrenomedullary system and increases synthesis of splenic PNMT by 20%, which both can modulate the immune function. (C) 2012 Elsevier B.V. All rights reserved.",
journal = "Journal of Neuroimmunology",
title = "Forced exercise changes catecholamine synthesis in the spleen of adult rats",
volume = "251",
number = "1-2",
pages = "1-5",
doi = "10.1016/j.jneuroim.2012.06.002"
}

Gavrilović, L., Stojiljković, V., Kasapović, J., Pejić, S., Todorović, A., Pajović, S. B.,& Dronjak, S.. (2012). Forced exercise changes catecholamine synthesis in the spleen of adult rats. in Journal of Neuroimmunology, 251(1-2), 1-5.
https://doi.org/10.1016/j.jneuroim.2012.06.002

Gavrilović L, Stojiljković V, Kasapović J, Pejić S, Todorović A, Pajović SB, Dronjak S. Forced exercise changes catecholamine synthesis in the spleen of adult rats. in Journal of Neuroimmunology. 2012;251(1-2):1-5.
doi:10.1016/j.jneuroim.2012.06.002 .

Gavrilović, Ljubica, Stojiljković, Vesna, Kasapović, Jelena, Pejić, Snežana, Todorović, Ana, Pajović, Snežana B., Dronjak, Slađana, "Forced exercise changes catecholamine synthesis in the spleen of adult rats" in Journal of Neuroimmunology, 251, no. 1-2 (2012):1-5,
https://doi.org/10.1016/j.jneuroim.2012.06.002 . .

TY  - JOUR
AU  - Gavrilović, Ljubica
AU  - Mandušić, Vesna
AU  - Stojiljković, Vesna
AU  - Kasapović, Jelena
AU  - Stojiljković, S.
AU  - Pajović, Snežana B.
AU  - Dronjak, Slađana
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5112
AB  - The sympathoneural system has a profound influence on the heart function. Sympathetic neurons are the major contributors to the huge rise of circulating noradrenaline (NA) level in response to stressful stimuli. Treadmill training in rats is forced exercise which has the propensity to induce both psychological and physical stress. The aim of this study is to examine how chronic forced running (CFR) affects the expression of catecholamine biosynthetic enzymes (tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT)) and cAMP response element-binding (CREB) in stellate ganglia, as well as the concentrations of catecholamines, adrenocorticotropic hormone (ACTH) and corticosterone (CORT) in the plasma of rats. Also, we investigated how the additional acute immobilization stress changes the mentioned parameters. The rat training program consisted of 12 weeks running on a treadmill (20 m/min, 20 min/day). We found that CFR increases TH and DBH mRNA and protein levels in stellate ganglia, which is followed by increased NA concentration in the plasma. CFR reduces the level of PNMT m RNA, while the level of PNMT protein remains unchanged in stellate ganglia. The increased expression of TH and DBH genes positively correlates with the expression of CREB in stellate ganglia and with plasma ACTH level, while reduced level of PNMT mRNA in stellate ganglia correlates with reduced plasma CORT level. The additional acute immobilization stress increased gene expression of catecholamine biosynthetic enzymes in stellate ganglia, as well as catecholamines, ACTH and CORT levels in the plasma. The results presented here suggest that the continuous increase of the noradrenaline biosynthetic enzyme expression in stellate ganglia due to CFR may play a role in growing risk of cardiovascular diseases.
T2  - Journal of Biological Regulators and Homeostatic Agents
T1  - Effect of Chronic Forced Running on Gene Expression of Catecholamine Biosynthetic Enzymes in Stellate Ganglia of Rats
VL  - 26
IS  - 3
SP  - 367
EP  - 377
UR  - https://hdl.handle.net/21.15107/rcub_vinar_5112
ER  - 

@article{
author = "Gavrilović, Ljubica and Mandušić, Vesna and Stojiljković, Vesna and Kasapović, Jelena and Stojiljković, S. and Pajović, Snežana B. and Dronjak, Slađana",
year = "2012",
abstract = "The sympathoneural system has a profound influence on the heart function. Sympathetic neurons are the major contributors to the huge rise of circulating noradrenaline (NA) level in response to stressful stimuli. Treadmill training in rats is forced exercise which has the propensity to induce both psychological and physical stress. The aim of this study is to examine how chronic forced running (CFR) affects the expression of catecholamine biosynthetic enzymes (tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT)) and cAMP response element-binding (CREB) in stellate ganglia, as well as the concentrations of catecholamines, adrenocorticotropic hormone (ACTH) and corticosterone (CORT) in the plasma of rats. Also, we investigated how the additional acute immobilization stress changes the mentioned parameters. The rat training program consisted of 12 weeks running on a treadmill (20 m/min, 20 min/day). We found that CFR increases TH and DBH mRNA and protein levels in stellate ganglia, which is followed by increased NA concentration in the plasma. CFR reduces the level of PNMT m RNA, while the level of PNMT protein remains unchanged in stellate ganglia. The increased expression of TH and DBH genes positively correlates with the expression of CREB in stellate ganglia and with plasma ACTH level, while reduced level of PNMT mRNA in stellate ganglia correlates with reduced plasma CORT level. The additional acute immobilization stress increased gene expression of catecholamine biosynthetic enzymes in stellate ganglia, as well as catecholamines, ACTH and CORT levels in the plasma. The results presented here suggest that the continuous increase of the noradrenaline biosynthetic enzyme expression in stellate ganglia due to CFR may play a role in growing risk of cardiovascular diseases.",
journal = "Journal of Biological Regulators and Homeostatic Agents",
title = "Effect of Chronic Forced Running on Gene Expression of Catecholamine Biosynthetic Enzymes in Stellate Ganglia of Rats",
volume = "26",
number = "3",
pages = "367-377",
url = "https://hdl.handle.net/21.15107/rcub_vinar_5112"
}

Gavrilović, L., Mandušić, V., Stojiljković, V., Kasapović, J., Stojiljković, S., Pajović, S. B.,& Dronjak, S.. (2012). Effect of Chronic Forced Running on Gene Expression of Catecholamine Biosynthetic Enzymes in Stellate Ganglia of Rats. in Journal of Biological Regulators and Homeostatic Agents, 26(3), 367-377.
https://hdl.handle.net/21.15107/rcub_vinar_5112

Gavrilović L, Mandušić V, Stojiljković V, Kasapović J, Stojiljković S, Pajović SB, Dronjak S. Effect of Chronic Forced Running on Gene Expression of Catecholamine Biosynthetic Enzymes in Stellate Ganglia of Rats. in Journal of Biological Regulators and Homeostatic Agents. 2012;26(3):367-377.
https://hdl.handle.net/21.15107/rcub_vinar_5112 .

Gavrilović, Ljubica, Mandušić, Vesna, Stojiljković, Vesna, Kasapović, Jelena, Stojiljković, S., Pajović, Snežana B., Dronjak, Slađana, "Effect of Chronic Forced Running on Gene Expression of Catecholamine Biosynthetic Enzymes in Stellate Ganglia of Rats" in Journal of Biological Regulators and Homeostatic Agents, 26, no. 3 (2012):367-377,
https://hdl.handle.net/21.15107/rcub_vinar_5112 .

TY  - JOUR
AU  - Stojiljković, Vesna
AU  - Pejić, Snežana
AU  - Kasapović, Jelena
AU  - Gavrilović, Ljubica
AU  - Stojiljković, Stanimir
AU  - Nikolić, Dragan
AU  - Pajović, Snežana B.
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4758
AB  - The celiac disease is an autoimmune gastrointestinal disorder caused by gluten from wheat, rye or barley. In genetically predisposed persons, gluten induces the immune-mediated inflammation of small intestinal mucosa. Histological lesions include intraepithelial lymphocytosis, crypt hypertrophy and villous atrophy, resulting in malabsorption of micro- and macronutrients. The only treatment for celiac patients is a permanent gluten-free diet (GFD). Reactive oxygen species (ROS) and oxidative stress are strongly associated with the celiac disease. Glutathione (GSH) is a main detoxifier of endogenous and exogenous ROS in the intestine. In order to explain the role of glutathione redox cycle in celiac patients, we examined the activities of GSH-related antioxidant (AO) enzymes glutathione peroxidase (GPx) and glutathione reductase (GR), as well as the concentration of GSH in small intestinal biopsies and peripheral blood of children affected by the celiac disease. The concentration of lipid hydroperoxides (LOOH) as markers of oxidative damage was measured in the same samples. The results clearly demonstrate a significant malfunction of GSH redox cycle with a concomitant decrease in the capacity to regenerate GSH and detoxify LOOH in celiac patients, even after several years of GFD. The oral administration of GSH and a diet rich in natural antioxidants, as well as appropriate dietary supplements, could be of great benefit to the patients.
T2  - Anais de Academia Brasileira de Ciencias
T1  - Glutathione redox cycle in small intestinal mucosa and peripheral blood of pediatric celiac disease patients
VL  - 84
IS  - 1
SP  - 175
EP  - 184
DO  - 10.1590/S0001-37652012000100018
ER  - 

@article{
author = "Stojiljković, Vesna and Pejić, Snežana and Kasapović, Jelena and Gavrilović, Ljubica and Stojiljković, Stanimir and Nikolić, Dragan and Pajović, Snežana B.",
year = "2012",
abstract = "The celiac disease is an autoimmune gastrointestinal disorder caused by gluten from wheat, rye or barley. In genetically predisposed persons, gluten induces the immune-mediated inflammation of small intestinal mucosa. Histological lesions include intraepithelial lymphocytosis, crypt hypertrophy and villous atrophy, resulting in malabsorption of micro- and macronutrients. The only treatment for celiac patients is a permanent gluten-free diet (GFD). Reactive oxygen species (ROS) and oxidative stress are strongly associated with the celiac disease. Glutathione (GSH) is a main detoxifier of endogenous and exogenous ROS in the intestine. In order to explain the role of glutathione redox cycle in celiac patients, we examined the activities of GSH-related antioxidant (AO) enzymes glutathione peroxidase (GPx) and glutathione reductase (GR), as well as the concentration of GSH in small intestinal biopsies and peripheral blood of children affected by the celiac disease. The concentration of lipid hydroperoxides (LOOH) as markers of oxidative damage was measured in the same samples. The results clearly demonstrate a significant malfunction of GSH redox cycle with a concomitant decrease in the capacity to regenerate GSH and detoxify LOOH in celiac patients, even after several years of GFD. The oral administration of GSH and a diet rich in natural antioxidants, as well as appropriate dietary supplements, could be of great benefit to the patients.",
journal = "Anais de Academia Brasileira de Ciencias",
title = "Glutathione redox cycle in small intestinal mucosa and peripheral blood of pediatric celiac disease patients",
volume = "84",
number = "1",
pages = "175-184",
doi = "10.1590/S0001-37652012000100018"
}

Stojiljković, V., Pejić, S., Kasapović, J., Gavrilović, L., Stojiljković, S., Nikolić, D.,& Pajović, S. B.. (2012). Glutathione redox cycle in small intestinal mucosa and peripheral blood of pediatric celiac disease patients. in Anais de Academia Brasileira de Ciencias, 84(1), 175-184.
https://doi.org/10.1590/S0001-37652012000100018

Stojiljković V, Pejić S, Kasapović J, Gavrilović L, Stojiljković S, Nikolić D, Pajović SB. Glutathione redox cycle in small intestinal mucosa and peripheral blood of pediatric celiac disease patients. in Anais de Academia Brasileira de Ciencias. 2012;84(1):175-184.
doi:10.1590/S0001-37652012000100018 .

Stojiljković, Vesna, Pejić, Snežana, Kasapović, Jelena, Gavrilović, Ljubica, Stojiljković, Stanimir, Nikolić, Dragan, Pajović, Snežana B., "Glutathione redox cycle in small intestinal mucosa and peripheral blood of pediatric celiac disease patients" in Anais de Academia Brasileira de Ciencias, 84, no. 1 (2012):175-184,
https://doi.org/10.1590/S0001-37652012000100018 . .

TY  - JOUR
AU  - Kasapović, Jelena
AU  - Pejić, Snežana
AU  - Stojiljković, Vesna
AU  - Todorović, Ana
AU  - Radosevic-Jelic, Ljiljana
AU  - Saičić, Zorica S.
AU  - Pajović, Snežana B.
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4107
AB  - Objectives: Breast carcinoma is related to the increase of lipid peroxidation in plasma with concomitant decrease of antioxidant (AO) defense capacity in blood cells, which becomes more pronounced during aging of the patients. This work evaluated the potential age-related effect of chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide (FAC) on the level of lipid hydroperoxides (LP), glutathione (GSH), AO enzyme activities of copper, zinc superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) in breast cancer patients. The level of CuZnSOD protein was assessed after the FAC therapy and radiotherapy of breast cancer. Design and methods: AO parameters were measured in the blood of 58 breast cancer patients and 60 healthy age-matched healthy subjects by biochemical and Western blot analyses. Results: Increased oxidative stress (LP: p LT 0.05) and decreased AO enzyme activities (CuZnSOD: p LT 0.01, GPx: p LT 0.05, GR: p LT 0.01) and GSH level (p LT 0.01) in the blood of breast cancer patients in response to FAC chemotherapy seem not to be age-dependent. CuZnSOD enzyme expression decreased after the FAC chemotherapy (p LT 0.05), while it increased after the radiotherapy of breast cancer (p LT 0.05). Conclusion: FAC chemotherapy and radiotherapy promote further oxidative shift, which potentiate already existing chronic oxidative stress linked to breast cancer. In these effects, impaired capacity for H2O2 detoxification (CAT. GPX and GSH) seems to have major contribution. (C) 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
T2  - Clinical Biochemistry
T1  - Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages after chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide
VL  - 43
IS  - 16-17
SP  - 1287
EP  - 1293
DO  - 10.1016/j.clinbiochem.2010.08.009
ER  - 

@article{
author = "Kasapović, Jelena and Pejić, Snežana and Stojiljković, Vesna and Todorović, Ana and Radosevic-Jelic, Ljiljana and Saičić, Zorica S. and Pajović, Snežana B.",
year = "2010",
abstract = "Objectives: Breast carcinoma is related to the increase of lipid peroxidation in plasma with concomitant decrease of antioxidant (AO) defense capacity in blood cells, which becomes more pronounced during aging of the patients. This work evaluated the potential age-related effect of chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide (FAC) on the level of lipid hydroperoxides (LP), glutathione (GSH), AO enzyme activities of copper, zinc superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) in breast cancer patients. The level of CuZnSOD protein was assessed after the FAC therapy and radiotherapy of breast cancer. Design and methods: AO parameters were measured in the blood of 58 breast cancer patients and 60 healthy age-matched healthy subjects by biochemical and Western blot analyses. Results: Increased oxidative stress (LP: p LT 0.05) and decreased AO enzyme activities (CuZnSOD: p LT 0.01, GPx: p LT 0.05, GR: p LT 0.01) and GSH level (p LT 0.01) in the blood of breast cancer patients in response to FAC chemotherapy seem not to be age-dependent. CuZnSOD enzyme expression decreased after the FAC chemotherapy (p LT 0.05), while it increased after the radiotherapy of breast cancer (p LT 0.05). Conclusion: FAC chemotherapy and radiotherapy promote further oxidative shift, which potentiate already existing chronic oxidative stress linked to breast cancer. In these effects, impaired capacity for H2O2 detoxification (CAT. GPX and GSH) seems to have major contribution. (C) 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.",
journal = "Clinical Biochemistry",
title = "Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages after chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide",
volume = "43",
number = "16-17",
pages = "1287-1293",
doi = "10.1016/j.clinbiochem.2010.08.009"
}

Kasapović, J., Pejić, S., Stojiljković, V., Todorović, A., Radosevic-Jelic, L., Saičić, Z. S.,& Pajović, S. B.. (2010). Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages after chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide. in Clinical Biochemistry, 43(16-17), 1287-1293.
https://doi.org/10.1016/j.clinbiochem.2010.08.009

Kasapović J, Pejić S, Stojiljković V, Todorović A, Radosevic-Jelic L, Saičić ZS, Pajović SB. Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages after chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide. in Clinical Biochemistry. 2010;43(16-17):1287-1293.
doi:10.1016/j.clinbiochem.2010.08.009 .

Kasapović, Jelena, Pejić, Snežana, Stojiljković, Vesna, Todorović, Ana, Radosevic-Jelic, Ljiljana, Saičić, Zorica S., Pajović, Snežana B., "Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages after chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide" in Clinical Biochemistry, 43, no. 16-17 (2010):1287-1293,
https://doi.org/10.1016/j.clinbiochem.2010.08.009 . .

TY  - JOUR
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Stojiljković, Vesna
AU  - Kasapović, Jelena
AU  - Pajović, Snežana B.
PY  - 2009
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3877
AB  - Background: Oxidative stress and impaired antioxidant system have been proposed as a potential factors involved in the pathophysiology of diverse disease states, including carcinogenesis. In this study, we explored the lipid peroxidation levels and antioxidant enzyme activities in women diagnosed with different forms of gynecological diseases in order to evaluate the antioxidant status in endometrium of such patients. Methods: Endometrial tissues of gynecological patients with different diagnoses were collected and subjected to assays for superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and lipid hydroperoxides. Results: Superoxide dismutase activity was significantly decreased (50% in average) in hyperplastic and adenocarcinoma patients. Activities of both glutathione peroxidase and glutathione reductase were increased 60% and 100% on average, in hyperplastic patients, while in adenocarcinoma patients only glutathione reductase activity was elevated 100%. Catalase activity was significantly decreased in adenocarcinoma patients (47%). Lipid hydroperoxides level was negatively correlated to superoxide dismutase and catalase activities, and positively correlated to glutathione peroxidase and glutathione reductase activities. Conclusions: This study provided the first comparison of antioxidant status and lipid peroxidation in endometrial tissues of patients with polyps, myoma, hyperplasia and adenocarcinoma. The results showed that patients with premalignant (hyperplastic) and malignant (adenocarcinoma) lesions had enhanced lipid peroxidation and altered uterine antioxidant enzyme activities than patients with benign uterine diseases, polyps and myoma, although the extent of disturbance varied with the diagnosis. Further investigation is needed to clarify the mechanisms responsible for the observed alterations and whether lipid hydroperoxide levels and antioxidant enzyme activities in uterus of gynecological patients might be used as additional parameter in clinical evaluation of gynecological disorders.
T2  - Reproductive Biology and Endocrinology
T1  - Antioxidant enzymes and lipid peroxidation in endometrium of patients with polyps, myoma, hyperplasia and adenocarcinoma
VL  - 7
DO  - 10.1186/1477-7827-7-149
ER  - 

@article{
author = "Pejić, Snežana and Todorović, Ana and Stojiljković, Vesna and Kasapović, Jelena and Pajović, Snežana B.",
year = "2009",
abstract = "Background: Oxidative stress and impaired antioxidant system have been proposed as a potential factors involved in the pathophysiology of diverse disease states, including carcinogenesis. In this study, we explored the lipid peroxidation levels and antioxidant enzyme activities in women diagnosed with different forms of gynecological diseases in order to evaluate the antioxidant status in endometrium of such patients. Methods: Endometrial tissues of gynecological patients with different diagnoses were collected and subjected to assays for superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and lipid hydroperoxides. Results: Superoxide dismutase activity was significantly decreased (50% in average) in hyperplastic and adenocarcinoma patients. Activities of both glutathione peroxidase and glutathione reductase were increased 60% and 100% on average, in hyperplastic patients, while in adenocarcinoma patients only glutathione reductase activity was elevated 100%. Catalase activity was significantly decreased in adenocarcinoma patients (47%). Lipid hydroperoxides level was negatively correlated to superoxide dismutase and catalase activities, and positively correlated to glutathione peroxidase and glutathione reductase activities. Conclusions: This study provided the first comparison of antioxidant status and lipid peroxidation in endometrial tissues of patients with polyps, myoma, hyperplasia and adenocarcinoma. The results showed that patients with premalignant (hyperplastic) and malignant (adenocarcinoma) lesions had enhanced lipid peroxidation and altered uterine antioxidant enzyme activities than patients with benign uterine diseases, polyps and myoma, although the extent of disturbance varied with the diagnosis. Further investigation is needed to clarify the mechanisms responsible for the observed alterations and whether lipid hydroperoxide levels and antioxidant enzyme activities in uterus of gynecological patients might be used as additional parameter in clinical evaluation of gynecological disorders.",
journal = "Reproductive Biology and Endocrinology",
title = "Antioxidant enzymes and lipid peroxidation in endometrium of patients with polyps, myoma, hyperplasia and adenocarcinoma",
volume = "7",
doi = "10.1186/1477-7827-7-149"
}

Pejić, S., Todorović, A., Stojiljković, V., Kasapović, J.,& Pajović, S. B.. (2009). Antioxidant enzymes and lipid peroxidation in endometrium of patients with polyps, myoma, hyperplasia and adenocarcinoma. in Reproductive Biology and Endocrinology, 7.
https://doi.org/10.1186/1477-7827-7-149

Pejić S, Todorović A, Stojiljković V, Kasapović J, Pajović SB. Antioxidant enzymes and lipid peroxidation in endometrium of patients with polyps, myoma, hyperplasia and adenocarcinoma. in Reproductive Biology and Endocrinology. 2009;7.
doi:10.1186/1477-7827-7-149 .

Pejić, Snežana, Todorović, Ana, Stojiljković, Vesna, Kasapović, Jelena, Pajović, Snežana B., "Antioxidant enzymes and lipid peroxidation in endometrium of patients with polyps, myoma, hyperplasia and adenocarcinoma" in Reproductive Biology and Endocrinology, 7 (2009),
https://doi.org/10.1186/1477-7827-7-149 . .

TY  - JOUR
AU  - Kasapović, Jelena
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Stojiljković, Vesna
AU  - Radosevic-Jelic, Ljiljana
AU  - Pajović, Snežana B.
PY  - 2009
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3689
AB  - In this study we investigated the effects of breast cancer radiotherapy on the antioxidant (AO) enzyme activities of copper, zinc superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR), as well as on the concentration of reduced glutathione (GSH) and lipid peroxides (LP) in blood of patients aged 45-58 years and older than 60 years. The results show that in blood of patients aged 45-58 years, radiotherapy increased the activities of CuZnSOD, CAT, and GR, as well as the concentration of GSH, without affecting the activity of GPx and concentration of LP. In patients older than 60 years, radiotherapy increased the activities of CuZnSOD and CAT, lowered the activity of GPx and concentration of GSH, and increased the concentration of LP. Our results indicate that the response to radiotherapy involves age-related impairment of AO capacity for elimination of H2O2, causing oxidative damage to blood cells. This suggests that cytotoxic effects of radiation on healthy tissues might be more pronounced during the aging of breast cancer patients, and should be considered in the further development of individualization protocols in cancer radiotherapy.
T2  - Archives of Biological Sciences
T1  - Antioxidant Status in Breast Cancer Patients of Different Ages After Radiotherapy
VL  - 61
IS  - 1
SP  - 23
EP  - 28
DO  - 10.2298/ABS0901023K
ER  - 

@article{
author = "Kasapović, Jelena and Pejić, Snežana and Todorović, Ana and Stojiljković, Vesna and Radosevic-Jelic, Ljiljana and Pajović, Snežana B.",
year = "2009",
abstract = "In this study we investigated the effects of breast cancer radiotherapy on the antioxidant (AO) enzyme activities of copper, zinc superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR), as well as on the concentration of reduced glutathione (GSH) and lipid peroxides (LP) in blood of patients aged 45-58 years and older than 60 years. The results show that in blood of patients aged 45-58 years, radiotherapy increased the activities of CuZnSOD, CAT, and GR, as well as the concentration of GSH, without affecting the activity of GPx and concentration of LP. In patients older than 60 years, radiotherapy increased the activities of CuZnSOD and CAT, lowered the activity of GPx and concentration of GSH, and increased the concentration of LP. Our results indicate that the response to radiotherapy involves age-related impairment of AO capacity for elimination of H2O2, causing oxidative damage to blood cells. This suggests that cytotoxic effects of radiation on healthy tissues might be more pronounced during the aging of breast cancer patients, and should be considered in the further development of individualization protocols in cancer radiotherapy.",
journal = "Archives of Biological Sciences",
title = "Antioxidant Status in Breast Cancer Patients of Different Ages After Radiotherapy",
volume = "61",
number = "1",
pages = "23-28",
doi = "10.2298/ABS0901023K"
}

Kasapović, J., Pejić, S., Todorović, A., Stojiljković, V., Radosevic-Jelic, L.,& Pajović, S. B.. (2009). Antioxidant Status in Breast Cancer Patients of Different Ages After Radiotherapy. in Archives of Biological Sciences, 61(1), 23-28.
https://doi.org/10.2298/ABS0901023K

Kasapović J, Pejić S, Todorović A, Stojiljković V, Radosevic-Jelic L, Pajović SB. Antioxidant Status in Breast Cancer Patients of Different Ages After Radiotherapy. in Archives of Biological Sciences. 2009;61(1):23-28.
doi:10.2298/ABS0901023K .

Kasapović, Jelena, Pejić, Snežana, Todorović, Ana, Stojiljković, Vesna, Radosevic-Jelic, Ljiljana, Pajović, Snežana B., "Antioxidant Status in Breast Cancer Patients of Different Ages After Radiotherapy" in Archives of Biological Sciences, 61, no. 1 (2009):23-28,
https://doi.org/10.2298/ABS0901023K . .

TY  - JOUR
AU  - Stojiljković, Vesna
AU  - Todorović, Ana
AU  - Pejić, Snežana
AU  - Kasapović, Jelena
AU  - Saičić, Zorica S.
AU  - Radlovic, Nedeljko
AU  - Pajović, Snežana B.
PY  - 2009
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3836
AB  - Objective: To explain the role of oxidative stress in the pathology of celiac disease. Design and methods: The activities of antioxidant enzymes and the levels of glutathione and lipid hydroperoxides were measured in the samples of small intestinal biopsies from 39 children with different forms of the disease and in 19 control subjects. Results: The activities of analyzed enzymes varied significantly between the examined groups. An increase in the activities of superoxide dismutase was observed in patients with active and silent celiac disease, while the activities of glutathione peroxidase and glutathione reductase and the glutathione content were significantly reduced. The level of lipid hydroperoxides was significantly elevated in these groups. Conclusions: Oxidative stress is an important factor in the pathogenesis of celiac disease. The antioxidant capacity of celiac patients is significantly reduced, mostly by a depletion of glutathione. Natural antioxidants and appropriate dietary supplements could be important complements to the classic therapy of celiac disease. (C) 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
T2  - Clinical Biochemistry
T1  - Antioxidant status and lipid peroxidation in small intestinal mucosa of children with celiac disease
VL  - 42
IS  - 13-14
SP  - 1431
EP  - 1437
DO  - 10.1016/j.clinbiochem.2009.06.009
ER  - 

@article{
author = "Stojiljković, Vesna and Todorović, Ana and Pejić, Snežana and Kasapović, Jelena and Saičić, Zorica S. and Radlovic, Nedeljko and Pajović, Snežana B.",
year = "2009",
abstract = "Objective: To explain the role of oxidative stress in the pathology of celiac disease. Design and methods: The activities of antioxidant enzymes and the levels of glutathione and lipid hydroperoxides were measured in the samples of small intestinal biopsies from 39 children with different forms of the disease and in 19 control subjects. Results: The activities of analyzed enzymes varied significantly between the examined groups. An increase in the activities of superoxide dismutase was observed in patients with active and silent celiac disease, while the activities of glutathione peroxidase and glutathione reductase and the glutathione content were significantly reduced. The level of lipid hydroperoxides was significantly elevated in these groups. Conclusions: Oxidative stress is an important factor in the pathogenesis of celiac disease. The antioxidant capacity of celiac patients is significantly reduced, mostly by a depletion of glutathione. Natural antioxidants and appropriate dietary supplements could be important complements to the classic therapy of celiac disease. (C) 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.",
journal = "Clinical Biochemistry",
title = "Antioxidant status and lipid peroxidation in small intestinal mucosa of children with celiac disease",
volume = "42",
number = "13-14",
pages = "1431-1437",
doi = "10.1016/j.clinbiochem.2009.06.009"
}

Stojiljković, V., Todorović, A., Pejić, S., Kasapović, J., Saičić, Z. S., Radlovic, N.,& Pajović, S. B.. (2009). Antioxidant status and lipid peroxidation in small intestinal mucosa of children with celiac disease. in Clinical Biochemistry, 42(13-14), 1431-1437.
https://doi.org/10.1016/j.clinbiochem.2009.06.009

Stojiljković V, Todorović A, Pejić S, Kasapović J, Saičić ZS, Radlovic N, Pajović SB. Antioxidant status and lipid peroxidation in small intestinal mucosa of children with celiac disease. in Clinical Biochemistry. 2009;42(13-14):1431-1437.
doi:10.1016/j.clinbiochem.2009.06.009 .

Stojiljković, Vesna, Todorović, Ana, Pejić, Snežana, Kasapović, Jelena, Saičić, Zorica S., Radlovic, Nedeljko, Pajović, Snežana B., "Antioxidant status and lipid peroxidation in small intestinal mucosa of children with celiac disease" in Clinical Biochemistry, 42, no. 13-14 (2009):1431-1437,
https://doi.org/10.1016/j.clinbiochem.2009.06.009 . .

TY  - JOUR
AU  - Kasapović, Jelena
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Stojiljković, Vesna
AU  - Pajović, Snežana B.
PY  - 2008
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3524
AB  - Oxidative stress is considered to be implicated in the pathophysiology of breast cancers. In this study we investigated the level of oxidative stress and antioxidant (AO) status in the blood of breast cancer patients of different ages. The level of lipid hydroperoxides (LP) was measured in blood plasma and the activities of copper, zinc superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) enzymes, as well as the level of total glutathione (GSH) and CuZnSOD protein were measured in blood cells of breast cancer patients and age-matched healthy subjects. Our results showed that breast carcinoma is related to increase of lipid peroxidation in plasma with concomitant decrease of AO defense capacity in blood cells, which becomes more pronounced during aging of the patients. Suppression of CuZnSOD activity related to breast cancer is most likely caused by decreased de novo synthesis of this enzyme. Similar patterns of suppression in CuZnSOD and CAT activities related to aging were recorded both in controls and patients. Age-related decrease in CuZnSOD activity seems not to be caused by altered protein levels of this enzyme. Suppression of AO enzymes associated with breast cancer and aging is most likely the cause of increased levels of reactive oxygen species (ROS). Our results indicate significant role of oxidative-induced injury in the breast carcinogenesis, particularly during the later stages of aging. Overall, Our data Support the importance of endogenous AOs in the etiology of breast cancer across all levels of predicted risk. Copyright (C) 2008 John Wiley and Sons, Ltd.
T2  - Cell Biochemistry and Function
T1  - Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages
VL  - 26
IS  - 6
SP  - 723
EP  - 730
DO  - 10.1002/cbf.1499
ER  - 

@article{
author = "Kasapović, Jelena and Pejić, Snežana and Todorović, Ana and Stojiljković, Vesna and Pajović, Snežana B.",
year = "2008",
abstract = "Oxidative stress is considered to be implicated in the pathophysiology of breast cancers. In this study we investigated the level of oxidative stress and antioxidant (AO) status in the blood of breast cancer patients of different ages. The level of lipid hydroperoxides (LP) was measured in blood plasma and the activities of copper, zinc superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) enzymes, as well as the level of total glutathione (GSH) and CuZnSOD protein were measured in blood cells of breast cancer patients and age-matched healthy subjects. Our results showed that breast carcinoma is related to increase of lipid peroxidation in plasma with concomitant decrease of AO defense capacity in blood cells, which becomes more pronounced during aging of the patients. Suppression of CuZnSOD activity related to breast cancer is most likely caused by decreased de novo synthesis of this enzyme. Similar patterns of suppression in CuZnSOD and CAT activities related to aging were recorded both in controls and patients. Age-related decrease in CuZnSOD activity seems not to be caused by altered protein levels of this enzyme. Suppression of AO enzymes associated with breast cancer and aging is most likely the cause of increased levels of reactive oxygen species (ROS). Our results indicate significant role of oxidative-induced injury in the breast carcinogenesis, particularly during the later stages of aging. Overall, Our data Support the importance of endogenous AOs in the etiology of breast cancer across all levels of predicted risk. Copyright (C) 2008 John Wiley and Sons, Ltd.",
journal = "Cell Biochemistry and Function",
title = "Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages",
volume = "26",
number = "6",
pages = "723-730",
doi = "10.1002/cbf.1499"
}

Kasapović, J., Pejić, S., Todorović, A., Stojiljković, V.,& Pajović, S. B.. (2008). Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages. in Cell Biochemistry and Function, 26(6), 723-730.
https://doi.org/10.1002/cbf.1499

Kasapović J, Pejić S, Todorović A, Stojiljković V, Pajović SB. Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages. in Cell Biochemistry and Function. 2008;26(6):723-730.
doi:10.1002/cbf.1499 .

Kasapović, Jelena, Pejić, Snežana, Todorović, Ana, Stojiljković, Vesna, Pajović, Snežana B., "Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages" in Cell Biochemistry and Function, 26, no. 6 (2008):723-730,
https://doi.org/10.1002/cbf.1499 . .

TY  - JOUR
AU  - Pejić, Snežana
AU  - Stojiljković, Vesna
AU  - Todorović, Ana
AU  - Kasapović, Jelena
AU  - Pajović, Snežana B.
PY  - 2007
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3418
T2  - Archives of Biological Sciences
T1  - Activity of manganese superoxide dismutase in rat brain exposed to acute, chronic, or combined stress
VL  - 59
IS  - 3
SP  - 39P
EP  - 40P
DO  - 10.2298/ABS070339PP
ER  - 

@article{
author = "Pejić, Snežana and Stojiljković, Vesna and Todorović, Ana and Kasapović, Jelena and Pajović, Snežana B.",
year = "2007",
journal = "Archives of Biological Sciences",
title = "Activity of manganese superoxide dismutase in rat brain exposed to acute, chronic, or combined stress",
volume = "59",
number = "3",
pages = "39P-40P",
doi = "10.2298/ABS070339PP"
}

Pejić, S., Stojiljković, V., Todorović, A., Kasapović, J.,& Pajović, S. B.. (2007). Activity of manganese superoxide dismutase in rat brain exposed to acute, chronic, or combined stress. in Archives of Biological Sciences, 59(3), 39P-40P.
https://doi.org/10.2298/ABS070339PP

Pejić S, Stojiljković V, Todorović A, Kasapović J, Pajović SB. Activity of manganese superoxide dismutase in rat brain exposed to acute, chronic, or combined stress. in Archives of Biological Sciences. 2007;59(3):39P-40P.
doi:10.2298/ABS070339PP .

Pejić, Snežana, Stojiljković, Vesna, Todorović, Ana, Kasapović, Jelena, Pajović, Snežana B., "Activity of manganese superoxide dismutase in rat brain exposed to acute, chronic, or combined stress" in Archives of Biological Sciences, 59, no. 3 (2007):39P-40P,
https://doi.org/10.2298/ABS070339PP . .

TY  - JOUR
AU  - Pejić, Snežana
AU  - Kasapović, Jelena
AU  - Todorović, Ana
AU  - Stojiljković, Vesna
AU  - Pajović, Snežana B.
PY  - 2006
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3262
AB  - Oxidative stress is considered to be involved in pathogenesis of many disorders of the female genital tract. In this study, we explored the lipid peroxidation levels and antioxidant enzyme activities in women diagnosed with different forms of uterine diseases in order to evaluate the extent of oxidative stress in blood of such patients. Blood samples of healthy subjects and gynecological patients were collected and subjected to assays for superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and lipid hydroperoxides. The results show that alterations of measured parameters vary with the enzyme type and diagnosis. However, both reduction in antioxidants and elevation of lipid peroxidation were observed in general. Lipid hydroperoxides level was negatively correlated to superoxide dismutase and glutathione peroxidase activities, as well as positively correlated to catalase activity. In addition, the lipid hydroperoxides/ glutathione peroxidase ratio was found to be increased, according to the type of uterine disease. The obtained results show that perturbation of antioxidant status is more pronounced in blood of patients with premalignant (hyperplastic) and malignant (adenocarcinoma) lesions, compared to those with benign uterine changes such as polypus and myoma.
T2  - Biological Research
T1  - Lipid peroxidation and antioxidant status in blood of patients with uterine myoma, endometrial polypus, hyperplastic and malignant endometrium
VL  - 39
IS  - 4
SP  - 619
EP  - 629
UR  - https://hdl.handle.net/21.15107/rcub_vinar_3262
ER  - 

@article{
author = "Pejić, Snežana and Kasapović, Jelena and Todorović, Ana and Stojiljković, Vesna and Pajović, Snežana B.",
year = "2006",
abstract = "Oxidative stress is considered to be involved in pathogenesis of many disorders of the female genital tract. In this study, we explored the lipid peroxidation levels and antioxidant enzyme activities in women diagnosed with different forms of uterine diseases in order to evaluate the extent of oxidative stress in blood of such patients. Blood samples of healthy subjects and gynecological patients were collected and subjected to assays for superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and lipid hydroperoxides. The results show that alterations of measured parameters vary with the enzyme type and diagnosis. However, both reduction in antioxidants and elevation of lipid peroxidation were observed in general. Lipid hydroperoxides level was negatively correlated to superoxide dismutase and glutathione peroxidase activities, as well as positively correlated to catalase activity. In addition, the lipid hydroperoxides/ glutathione peroxidase ratio was found to be increased, according to the type of uterine disease. The obtained results show that perturbation of antioxidant status is more pronounced in blood of patients with premalignant (hyperplastic) and malignant (adenocarcinoma) lesions, compared to those with benign uterine changes such as polypus and myoma.",
journal = "Biological Research",
title = "Lipid peroxidation and antioxidant status in blood of patients with uterine myoma, endometrial polypus, hyperplastic and malignant endometrium",
volume = "39",
number = "4",
pages = "619-629",
url = "https://hdl.handle.net/21.15107/rcub_vinar_3262"
}

Pejić, S., Kasapović, J., Todorović, A., Stojiljković, V.,& Pajović, S. B.. (2006). Lipid peroxidation and antioxidant status in blood of patients with uterine myoma, endometrial polypus, hyperplastic and malignant endometrium. in Biological Research, 39(4), 619-629.
https://hdl.handle.net/21.15107/rcub_vinar_3262

Pejić S, Kasapović J, Todorović A, Stojiljković V, Pajović SB. Lipid peroxidation and antioxidant status in blood of patients with uterine myoma, endometrial polypus, hyperplastic and malignant endometrium. in Biological Research. 2006;39(4):619-629.
https://hdl.handle.net/21.15107/rcub_vinar_3262 .

Pejić, Snežana, Kasapović, Jelena, Todorović, Ana, Stojiljković, Vesna, Pajović, Snežana B., "Lipid peroxidation and antioxidant status in blood of patients with uterine myoma, endometrial polypus, hyperplastic and malignant endometrium" in Biological Research, 39, no. 4 (2006):619-629,
https://hdl.handle.net/21.15107/rcub_vinar_3262 .

TY  - JOUR
AU  - Todorović, Ana
AU  - Kasapović, Jelena
AU  - Pejić, Snežana
AU  - Stojiljković, Vesna
AU  - Pajović, Snežana B.
PY  - 2005
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6553
AB  - Ionizing radiation increases intracellular production of reactive oxygen species, which can damage cell structure and function. The brain is particularly vulnerable to oxidative injury, and in an area-dependent manner. In order to elucidate differences in enzymatic antioxidative response of rat hippocampus and cortex, we measured activities of CuZnSOD, MnSOD, and CAT in those two brain regions, isolated 1h and 24 h after exposure to 2 Gy of gamma-rays. Our results indicate that lower MnSOD activities and inducibility, found in the hippocampus, are probably some of the main reasons for the particularly great oxidative vulnerability of this brain region.
T2  - Annals of the New York Academy of Sciences
T1  - Differences in antioxidative response of rat hippocampus and cortex after exposure to clinical dose of gamma-rays
VL  - 1048
SP  - 369
EP  - 372
DO  - 10.1196/annals.1342.041
ER  - 

@article{
author = "Todorović, Ana and Kasapović, Jelena and Pejić, Snežana and Stojiljković, Vesna and Pajović, Snežana B.",
year = "2005",
abstract = "Ionizing radiation increases intracellular production of reactive oxygen species, which can damage cell structure and function. The brain is particularly vulnerable to oxidative injury, and in an area-dependent manner. In order to elucidate differences in enzymatic antioxidative response of rat hippocampus and cortex, we measured activities of CuZnSOD, MnSOD, and CAT in those two brain regions, isolated 1h and 24 h after exposure to 2 Gy of gamma-rays. Our results indicate that lower MnSOD activities and inducibility, found in the hippocampus, are probably some of the main reasons for the particularly great oxidative vulnerability of this brain region.",
journal = "Annals of the New York Academy of Sciences",
title = "Differences in antioxidative response of rat hippocampus and cortex after exposure to clinical dose of gamma-rays",
volume = "1048",
pages = "369-372",
doi = "10.1196/annals.1342.041"
}

Todorović, A., Kasapović, J., Pejić, S., Stojiljković, V.,& Pajović, S. B.. (2005). Differences in antioxidative response of rat hippocampus and cortex after exposure to clinical dose of gamma-rays. in Annals of the New York Academy of Sciences, 1048, 369-372.
https://doi.org/10.1196/annals.1342.041

Todorović A, Kasapović J, Pejić S, Stojiljković V, Pajović SB. Differences in antioxidative response of rat hippocampus and cortex after exposure to clinical dose of gamma-rays. in Annals of the New York Academy of Sciences. 2005;1048:369-372.
doi:10.1196/annals.1342.041 .

Todorović, Ana, Kasapović, Jelena, Pejić, Snežana, Stojiljković, Vesna, Pajović, Snežana B., "Differences in antioxidative response of rat hippocampus and cortex after exposure to clinical dose of gamma-rays" in Annals of the New York Academy of Sciences, 1048 (2005):369-372,
https://doi.org/10.1196/annals.1342.041 . .

TY  - JOUR
AU  - Stojiljković, Vesna
AU  - Todorović, Ana
AU  - Kasapović, Jelena
AU  - Pejić, Snežana
AU  - Pajović, Snežana B.
PY  - 2005
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6554
AB  - Chronic exposure to stress alters the prooxidant-antioxidant balance, which might lead to the development of various human pathological states. In order to explain the role of antioxidant response in stress-induced injury, we examined the effects of two types of acute stress, as well as combined effects of chronic and acute stress on manganese-superoxide dismutase, copper,zinc-superoxide dismutase, and catalase activities in rat brain hippocampus. Our results show that chronic stress induces an increase in oxidative enzyme activities and that adaptation to chronic stress might alter hippocampal antioxidant mechanisms response to acute stress.
T2  - Annals of the New York Academy of Sciences
T1  - Antioxidant enzyme activity in rat hippocampus after chronic and acute stress exposure
VL  - 1048
SP  - 373
EP  - 376
DO  - 10.1196/annals.1342.042
ER  - 

@article{
author = "Stojiljković, Vesna and Todorović, Ana and Kasapović, Jelena and Pejić, Snežana and Pajović, Snežana B.",
year = "2005",
abstract = "Chronic exposure to stress alters the prooxidant-antioxidant balance, which might lead to the development of various human pathological states. In order to explain the role of antioxidant response in stress-induced injury, we examined the effects of two types of acute stress, as well as combined effects of chronic and acute stress on manganese-superoxide dismutase, copper,zinc-superoxide dismutase, and catalase activities in rat brain hippocampus. Our results show that chronic stress induces an increase in oxidative enzyme activities and that adaptation to chronic stress might alter hippocampal antioxidant mechanisms response to acute stress.",
journal = "Annals of the New York Academy of Sciences",
title = "Antioxidant enzyme activity in rat hippocampus after chronic and acute stress exposure",
volume = "1048",
pages = "373-376",
doi = "10.1196/annals.1342.042"
}

Stojiljković, V., Todorović, A., Kasapović, J., Pejić, S.,& Pajović, S. B.. (2005). Antioxidant enzyme activity in rat hippocampus after chronic and acute stress exposure. in Annals of the New York Academy of Sciences, 1048, 373-376.
https://doi.org/10.1196/annals.1342.042

Stojiljković V, Todorović A, Kasapović J, Pejić S, Pajović SB. Antioxidant enzyme activity in rat hippocampus after chronic and acute stress exposure. in Annals of the New York Academy of Sciences. 2005;1048:373-376.
doi:10.1196/annals.1342.042 .

Stojiljković, Vesna, Todorović, Ana, Kasapović, Jelena, Pejić, Snežana, Pajović, Snežana B., "Antioxidant enzyme activity in rat hippocampus after chronic and acute stress exposure" in Annals of the New York Academy of Sciences, 1048 (2005):373-376,
https://doi.org/10.1196/annals.1342.042 . .

TY  - JOUR
AU  - Filipović, Dragana
AU  - Kasapović, Jelena
AU  - Pejić, Snežana
AU  - Nićiforović, Ana
AU  - Pajović, Snežana B.
AU  - Radoičić, Marija
PY  - 2005
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2941
AB  - Specific composition, protein profiles and total SOD activity were analysed in full milk samples obtained from five farms of the Milk Company IMPAZ The effects of several laboratory treatments on milk proteins SDS-PAGE profiles and the respective SOD activity were also followed. The total SOD activity was detected in all full milk samples, and its values varied between 2 and 3 U mg(-1) protein. The enzyme could be partially purified, up to approximate to 5 U mg(-1) protein, by ethanol extraction. The recovered SOD activity in ethanol extract was proportional to the initial full milk SOD activity. The disruption of casein micelles by Ca2+ removal was followed by a significant decrease in SOD activity to 1.24-0.18 U mg(-1) protein. The loss of enzyme activity was ascribed to the changes in milk milieu induced by dissociation of casein micelles.
T2  - Acta Alimentaria
T1  - Superoxide dismutase activity in various fractions of full bovine milk
VL  - 34
IS  - 3
SP  - 219
EP  - 226
DO  - 10.1556/AAlim.34.2005.3.3
ER  - 

@article{
author = "Filipović, Dragana and Kasapović, Jelena and Pejić, Snežana and Nićiforović, Ana and Pajović, Snežana B. and Radoičić, Marija",
year = "2005",
abstract = "Specific composition, protein profiles and total SOD activity were analysed in full milk samples obtained from five farms of the Milk Company IMPAZ The effects of several laboratory treatments on milk proteins SDS-PAGE profiles and the respective SOD activity were also followed. The total SOD activity was detected in all full milk samples, and its values varied between 2 and 3 U mg(-1) protein. The enzyme could be partially purified, up to approximate to 5 U mg(-1) protein, by ethanol extraction. The recovered SOD activity in ethanol extract was proportional to the initial full milk SOD activity. The disruption of casein micelles by Ca2+ removal was followed by a significant decrease in SOD activity to 1.24-0.18 U mg(-1) protein. The loss of enzyme activity was ascribed to the changes in milk milieu induced by dissociation of casein micelles.",
journal = "Acta Alimentaria",
title = "Superoxide dismutase activity in various fractions of full bovine milk",
volume = "34",
number = "3",
pages = "219-226",
doi = "10.1556/AAlim.34.2005.3.3"
}

Filipović, D., Kasapović, J., Pejić, S., Nićiforović, A., Pajović, S. B.,& Radoičić, M.. (2005). Superoxide dismutase activity in various fractions of full bovine milk. in Acta Alimentaria, 34(3), 219-226.
https://doi.org/10.1556/AAlim.34.2005.3.3

Filipović D, Kasapović J, Pejić S, Nićiforović A, Pajović SB, Radoičić M. Superoxide dismutase activity in various fractions of full bovine milk. in Acta Alimentaria. 2005;34(3):219-226.
doi:10.1556/AAlim.34.2005.3.3 .

Filipović, Dragana, Kasapović, Jelena, Pejić, Snežana, Nićiforović, Ana, Pajović, Snežana B., Radoičić, Marija, "Superoxide dismutase activity in various fractions of full bovine milk" in Acta Alimentaria, 34, no. 3 (2005):219-226,
https://doi.org/10.1556/AAlim.34.2005.3.3 . .

TY  - JOUR
AU  - Kasapović, Jelena
AU  - Pejić, Snežana
AU  - Mladenovic, M
AU  - Radlovic, N
AU  - Pajović, Snežana B.
PY  - 2005
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2952
AB  - Colostrum and mature human milk are rich sources of nutrients and contain biologically active molecules that are essential for specific antioxidant functions. The aim of the present study was to determine the activity of copper, zinc superoxide dismutase (CuZnSOD) and manganese superoxide dismutase (MnSOD) activity in different phases of lactation. Specific enzyme activity was determined in colostral milk (3(rd)-5(th) days after delivery), and in mature milk in the third week (15-20 days), and the fourth and seventh months of lactation. In the third week of lactation, the activity of CuZnSOD and MnSOD was significantly higher in comparison to the colostral phase. In the fourth month of lactation, the activity of both enzymes was suppressed, while in the seventh month of lactation the MnSOD activity was increased, and the CuZnSOD activity was not significantly changed. These findings show that the activities of superoxide dismutases significantly change during different phases of lactation.
T2  - Turkish Journal of Pediatrics
T1  - Superoxide dismutase activity in colostrum, transitional and mature human milk
VL  - 47
IS  - 4
SP  - 343
EP  - 347
UR  - https://hdl.handle.net/21.15107/rcub_vinar_2952
ER  - 

@article{
author = "Kasapović, Jelena and Pejić, Snežana and Mladenovic, M and Radlovic, N and Pajović, Snežana B.",
year = "2005",
abstract = "Colostrum and mature human milk are rich sources of nutrients and contain biologically active molecules that are essential for specific antioxidant functions. The aim of the present study was to determine the activity of copper, zinc superoxide dismutase (CuZnSOD) and manganese superoxide dismutase (MnSOD) activity in different phases of lactation. Specific enzyme activity was determined in colostral milk (3(rd)-5(th) days after delivery), and in mature milk in the third week (15-20 days), and the fourth and seventh months of lactation. In the third week of lactation, the activity of CuZnSOD and MnSOD was significantly higher in comparison to the colostral phase. In the fourth month of lactation, the activity of both enzymes was suppressed, while in the seventh month of lactation the MnSOD activity was increased, and the CuZnSOD activity was not significantly changed. These findings show that the activities of superoxide dismutases significantly change during different phases of lactation.",
journal = "Turkish Journal of Pediatrics",
title = "Superoxide dismutase activity in colostrum, transitional and mature human milk",
volume = "47",
number = "4",
pages = "343-347",
url = "https://hdl.handle.net/21.15107/rcub_vinar_2952"
}

Kasapović, J., Pejić, S., Mladenovic, M., Radlovic, N.,& Pajović, S. B.. (2005). Superoxide dismutase activity in colostrum, transitional and mature human milk. in Turkish Journal of Pediatrics, 47(4), 343-347.
https://hdl.handle.net/21.15107/rcub_vinar_2952

Kasapović J, Pejić S, Mladenovic M, Radlovic N, Pajović SB. Superoxide dismutase activity in colostrum, transitional and mature human milk. in Turkish Journal of Pediatrics. 2005;47(4):343-347.
https://hdl.handle.net/21.15107/rcub_vinar_2952 .

Kasapović, Jelena, Pejić, Snežana, Mladenovic, M, Radlovic, N, Pajović, Snežana B., "Superoxide dismutase activity in colostrum, transitional and mature human milk" in Turkish Journal of Pediatrics, 47, no. 4 (2005):343-347,
https://hdl.handle.net/21.15107/rcub_vinar_2952 .

TY  - JOUR
AU  - Pejić, Snežana
AU  - Kasapović, Jelena
AU  - Cvetković, D
AU  - Pajović, Snežana B.
PY  - 2003
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2634
AB  - The sensitivity of copper,zinc (CuZn)- and manganese (Mn)-superoxide dismutase (SOD) to exogenous estradiol benzoate (EB) was investigated in Wistar rats during postnatal brain development. Enzyme activities were measured in samples prepared from brains of rats of both sexes and various ages between 0 and 75 days, treated sc with 0.5 mug EB/100 g body weight in 0.1 ml olive oil/100 g body weight, 48 and 24 h before sacrifice. In females, EB treatment stimulated MnSOD activity on days 0 (66.1%), 8 (72.7%) and 15 (81.7%). In males, the stimulatory effect of EB on MnSOD activity on day 0 (113.6%) disappeared on day 8 and on days 15. and 45 it became inhibitory (40.3 and 30.5%, respectively). EB had no effect on the other age groups. The stimulatory effect of EB on CuZnSOD activity in newborn females (51.8%) changed to an inhibitory effect on day 8 (38.4%) and disappeared by day 45 when inhibition was detected again (48.7%). In males, the inhibitory effect on this enzyme was observed on days 0 (45.0%) and 15 (28.9%), and then disappeared until day 60 when a stimulatory effect was observed (38.4%). EB treatment had no effect on the other age groups. The sensitivity of MnSOD to estradiol differed significantly between sexes during the neonatal and prepubertal period, whereas it followed a similar pattern thereafter. The sensitivity of CuZnSOD to estradiol differed significantly between sexes during most of the study period. Regression analysis showed that the sensitivity of MnSOD to this estrogen tended to decrease similarly in both sexes, whereas the sensitivity of CuZnSOD showed a significantly different opposite tendency in female and male rats. These are the first reports indicating hormonal modulation of antioxidant enzyme activities related to the developmental process.
T2  - Brazilian Journal of Medical and Biological Research
T1  - The modulatory effect of estradiol benzoate on superoxide dismutase activity in the developing rat brain
VL  - 36
IS  - 5
SP  - 579
EP  - 586
DO  - 10.1590/S0100-879X2003000500004
ER  - 

@article{
author = "Pejić, Snežana and Kasapović, Jelena and Cvetković, D and Pajović, Snežana B.",
year = "2003",
abstract = "The sensitivity of copper,zinc (CuZn)- and manganese (Mn)-superoxide dismutase (SOD) to exogenous estradiol benzoate (EB) was investigated in Wistar rats during postnatal brain development. Enzyme activities were measured in samples prepared from brains of rats of both sexes and various ages between 0 and 75 days, treated sc with 0.5 mug EB/100 g body weight in 0.1 ml olive oil/100 g body weight, 48 and 24 h before sacrifice. In females, EB treatment stimulated MnSOD activity on days 0 (66.1%), 8 (72.7%) and 15 (81.7%). In males, the stimulatory effect of EB on MnSOD activity on day 0 (113.6%) disappeared on day 8 and on days 15. and 45 it became inhibitory (40.3 and 30.5%, respectively). EB had no effect on the other age groups. The stimulatory effect of EB on CuZnSOD activity in newborn females (51.8%) changed to an inhibitory effect on day 8 (38.4%) and disappeared by day 45 when inhibition was detected again (48.7%). In males, the inhibitory effect on this enzyme was observed on days 0 (45.0%) and 15 (28.9%), and then disappeared until day 60 when a stimulatory effect was observed (38.4%). EB treatment had no effect on the other age groups. The sensitivity of MnSOD to estradiol differed significantly between sexes during the neonatal and prepubertal period, whereas it followed a similar pattern thereafter. The sensitivity of CuZnSOD to estradiol differed significantly between sexes during most of the study period. Regression analysis showed that the sensitivity of MnSOD to this estrogen tended to decrease similarly in both sexes, whereas the sensitivity of CuZnSOD showed a significantly different opposite tendency in female and male rats. These are the first reports indicating hormonal modulation of antioxidant enzyme activities related to the developmental process.",
journal = "Brazilian Journal of Medical and Biological Research",
title = "The modulatory effect of estradiol benzoate on superoxide dismutase activity in the developing rat brain",
volume = "36",
number = "5",
pages = "579-586",
doi = "10.1590/S0100-879X2003000500004"
}

Pejić, S., Kasapović, J., Cvetković, D.,& Pajović, S. B.. (2003). The modulatory effect of estradiol benzoate on superoxide dismutase activity in the developing rat brain. in Brazilian Journal of Medical and Biological Research, 36(5), 579-586.
https://doi.org/10.1590/S0100-879X2003000500004

Pejić S, Kasapović J, Cvetković D, Pajović SB. The modulatory effect of estradiol benzoate on superoxide dismutase activity in the developing rat brain. in Brazilian Journal of Medical and Biological Research. 2003;36(5):579-586.
doi:10.1590/S0100-879X2003000500004 .

Pejić, Snežana, Kasapović, Jelena, Cvetković, D, Pajović, Snežana B., "The modulatory effect of estradiol benzoate on superoxide dismutase activity in the developing rat brain" in Brazilian Journal of Medical and Biological Research, 36, no. 5 (2003):579-586,
https://doi.org/10.1590/S0100-879X2003000500004 . .

TY  - JOUR
AU  - Kasapović, Jelena
AU  - Pajović, Snežana B.
AU  - Pejić, Snežana
AU  - Martinović, Jelena
PY  - 2001
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2422
AB  - The activity of mitochondrial superoxide dismutase (MnSOD) and cytosol superoxide dismutase (CuZnSOD) was measured in corresponding subcellular fractions prepared from the thymi of intact and chronically gonadectomized (GX) rats of both sexes, as well as of GX male and female rats injected subcutaneously with a single dose of 5 mug estradiol benzoate (EB) and/or 2 mg progesterone (P). Animals were sacrificed 2 h or 24 h following hormone treatment. In the females, the activity of MnSOD in the thymus was stable during the estrous cycle and did not change after ovariectomy. Treatment of GX females with estradiol benzoate resulted 2 h later in a significant elevation of MnSOD activity, whereas 24 h later the activity returned back to control values. On the other hand, treatment of GX females with progesterone had no effect on the MnSOD activity. However, combined hormone treatment, in which EB injection preceded progesterone injection by one hour, enhanced the effect on MnSOD activity similar to that of estradiol benzoate alone. The activity of CuZnSOD in cycling rats was increased in proestrus, whereas removal of the ovaries kept the values at low diestrus and estrus levels. Contrary to MnSOD, CuZnSOD activity did not change after EB treatment of GX females, while progesterone increased the enzyme activity at 2 h and 24 h after hormone treatment. However, combined EB+P treatment proved to be ineffective. In the males, neither MnSOD nor CuZnSOD activity was affected by the removal of testes or by progesterone treatment of GX animals. Only EB injection to GX rats significantly increased CuZnSOD activity 24 h later.
T2  - Physiological Research
T1  - Effects of estradiol benzoate and progesterone on superoxide dismutase activity in the thymus of rats
VL  - 50
IS  - 1
SP  - 97
EP  - 103
UR  - https://hdl.handle.net/21.15107/rcub_vinar_2422
ER  - 

@article{
author = "Kasapović, Jelena and Pajović, Snežana B. and Pejić, Snežana and Martinović, Jelena",
year = "2001",
abstract = "The activity of mitochondrial superoxide dismutase (MnSOD) and cytosol superoxide dismutase (CuZnSOD) was measured in corresponding subcellular fractions prepared from the thymi of intact and chronically gonadectomized (GX) rats of both sexes, as well as of GX male and female rats injected subcutaneously with a single dose of 5 mug estradiol benzoate (EB) and/or 2 mg progesterone (P). Animals were sacrificed 2 h or 24 h following hormone treatment. In the females, the activity of MnSOD in the thymus was stable during the estrous cycle and did not change after ovariectomy. Treatment of GX females with estradiol benzoate resulted 2 h later in a significant elevation of MnSOD activity, whereas 24 h later the activity returned back to control values. On the other hand, treatment of GX females with progesterone had no effect on the MnSOD activity. However, combined hormone treatment, in which EB injection preceded progesterone injection by one hour, enhanced the effect on MnSOD activity similar to that of estradiol benzoate alone. The activity of CuZnSOD in cycling rats was increased in proestrus, whereas removal of the ovaries kept the values at low diestrus and estrus levels. Contrary to MnSOD, CuZnSOD activity did not change after EB treatment of GX females, while progesterone increased the enzyme activity at 2 h and 24 h after hormone treatment. However, combined EB+P treatment proved to be ineffective. In the males, neither MnSOD nor CuZnSOD activity was affected by the removal of testes or by progesterone treatment of GX animals. Only EB injection to GX rats significantly increased CuZnSOD activity 24 h later.",
journal = "Physiological Research",
title = "Effects of estradiol benzoate and progesterone on superoxide dismutase activity in the thymus of rats",
volume = "50",
number = "1",
pages = "97-103",
url = "https://hdl.handle.net/21.15107/rcub_vinar_2422"
}

Kasapović, J., Pajović, S. B., Pejić, S.,& Martinović, J.. (2001). Effects of estradiol benzoate and progesterone on superoxide dismutase activity in the thymus of rats. in Physiological Research, 50(1), 97-103.
https://hdl.handle.net/21.15107/rcub_vinar_2422

Kasapović J, Pajović SB, Pejić S, Martinović J. Effects of estradiol benzoate and progesterone on superoxide dismutase activity in the thymus of rats. in Physiological Research. 2001;50(1):97-103.
https://hdl.handle.net/21.15107/rcub_vinar_2422 .

Kasapović, Jelena, Pajović, Snežana B., Pejić, Snežana, Martinović, Jelena, "Effects of estradiol benzoate and progesterone on superoxide dismutase activity in the thymus of rats" in Physiological Research, 50, no. 1 (2001):97-103,
https://hdl.handle.net/21.15107/rcub_vinar_2422 .

TY  - JOUR
AU  - Joksić, Gordana
AU  - Pajović, Snežana B.
AU  - Stankovic, M
AU  - Pejić, Snežana
AU  - Kasapović, Jelena
AU  - Cuttone, Giacomo
AU  - Calonghi, N
AU  - Masotti, L
AU  - Kanazir, Dušan T.
PY  - 2000
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2358
AB  - The goal of this study was to provide data on the dose-dependent production of dicentrics and micronuclei in human lymphocytes irradiated with 22.6 MeV protons and to estimate the possible contribution of intracellular superoxide dismutases (SOD) to the relative biological effectiveness (RBE) of protons. For the dose-response study, heparinized whole blood of a healthy volunteer was irradiated with protons and Xrays employing radiation doses of 0.5-4 Gy. Three biological endpoints were analyzed: chromosomal aberrations, micronuclei, and specific activity of cytosolic (CuZnSOD) and mitochondrial (MnSOD) superoxide dismutases in harvested human blood cells. Dicentric dose-response curves fit a linear-quadratic form (alpha = 0.094 +/- 0.006, beta = 0.032 +/- 0.001) induced with X-rays and (alpha = 0.119 +/- 0.057, beta = 0.029 +/- 0.014) for 22.6 MeV protons. Protons were more effective than X-rays in producing exchanges, particularly at 0.5 and 1 Gy. In contrast to X-ray irradiated samples where a significant increase in the specific activity of MnSOD was recorded (up to a radiation dose of 1 Gy), irradiation with protons markedly reduced its activity. As a consequence of the reduced activity of MnSOD, the chromosomal dose-response curve became quadratic. The RBE for dicentrics varies with dose (from 2.2 to 1.01) and reduced activity of MnSOD is an important contributor to the RBE of protons. SODs, particularly MnSOD, play an important role in defending DNA from reactive oxygen species. A reduced activity of SOD, particularly MnSOD, is an important contributor to the RBE of protons.
T2  - Cellular and Molecular Life Sciences / CMLS
T1  - Chromosome aberrations, micronuclei, and activity of superoxide dismutases in human lymphocytes after irradiation in vitro
VL  - 57
IS  - 5
SP  - 842
EP  - 850
DO  - 10.1007/s000180050046
ER  - 

@article{
author = "Joksić, Gordana and Pajović, Snežana B. and Stankovic, M and Pejić, Snežana and Kasapović, Jelena and Cuttone, Giacomo and Calonghi, N and Masotti, L and Kanazir, Dušan T.",
year = "2000",
abstract = "The goal of this study was to provide data on the dose-dependent production of dicentrics and micronuclei in human lymphocytes irradiated with 22.6 MeV protons and to estimate the possible contribution of intracellular superoxide dismutases (SOD) to the relative biological effectiveness (RBE) of protons. For the dose-response study, heparinized whole blood of a healthy volunteer was irradiated with protons and Xrays employing radiation doses of 0.5-4 Gy. Three biological endpoints were analyzed: chromosomal aberrations, micronuclei, and specific activity of cytosolic (CuZnSOD) and mitochondrial (MnSOD) superoxide dismutases in harvested human blood cells. Dicentric dose-response curves fit a linear-quadratic form (alpha = 0.094 +/- 0.006, beta = 0.032 +/- 0.001) induced with X-rays and (alpha = 0.119 +/- 0.057, beta = 0.029 +/- 0.014) for 22.6 MeV protons. Protons were more effective than X-rays in producing exchanges, particularly at 0.5 and 1 Gy. In contrast to X-ray irradiated samples where a significant increase in the specific activity of MnSOD was recorded (up to a radiation dose of 1 Gy), irradiation with protons markedly reduced its activity. As a consequence of the reduced activity of MnSOD, the chromosomal dose-response curve became quadratic. The RBE for dicentrics varies with dose (from 2.2 to 1.01) and reduced activity of MnSOD is an important contributor to the RBE of protons. SODs, particularly MnSOD, play an important role in defending DNA from reactive oxygen species. A reduced activity of SOD, particularly MnSOD, is an important contributor to the RBE of protons.",
journal = "Cellular and Molecular Life Sciences / CMLS",
title = "Chromosome aberrations, micronuclei, and activity of superoxide dismutases in human lymphocytes after irradiation in vitro",
volume = "57",
number = "5",
pages = "842-850",
doi = "10.1007/s000180050046"
}

Joksić, G., Pajović, S. B., Stankovic, M., Pejić, S., Kasapović, J., Cuttone, G., Calonghi, N., Masotti, L.,& Kanazir, D. T.. (2000). Chromosome aberrations, micronuclei, and activity of superoxide dismutases in human lymphocytes after irradiation in vitro. in Cellular and Molecular Life Sciences / CMLS, 57(5), 842-850.
https://doi.org/10.1007/s000180050046

Joksić G, Pajović SB, Stankovic M, Pejić S, Kasapović J, Cuttone G, Calonghi N, Masotti L, Kanazir DT. Chromosome aberrations, micronuclei, and activity of superoxide dismutases in human lymphocytes after irradiation in vitro. in Cellular and Molecular Life Sciences / CMLS. 2000;57(5):842-850.
doi:10.1007/s000180050046 .

Joksić, Gordana, Pajović, Snežana B., Stankovic, M, Pejić, Snežana, Kasapović, Jelena, Cuttone, Giacomo, Calonghi, N, Masotti, L, Kanazir, Dušan T., "Chromosome aberrations, micronuclei, and activity of superoxide dismutases in human lymphocytes after irradiation in vitro" in Cellular and Molecular Life Sciences / CMLS, 57, no. 5 (2000):842-850,
https://doi.org/10.1007/s000180050046 . .

TY  - JOUR
AU  - Pejić, Snežana
AU  - Kasapović, Jelena
AU  - Pajović, Snežana B.
PY  - 1999
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2283
AB  - Changes in the activity of brain antioxidant superoxide dismutases (SOD) were followed in newborn and young female rats 8, 15, 30, 45, 60 and 75 days after birth treated with olive oil. In newborn rats, the content of brain cytosol SOD (CuZnSOD) and mitochondrial SOD (MnSOD) decreased after treatment with olive oil. However, in the brain of rats aged 8 days this effect was lost. The suppressive effect of olive oil on these enzymes reappeared again in 15-day-old rats. In rats aged one month, only the activity of CuZnSOD was reduced after olive oil treatment. In the brain of rats aged 45, 60 and 75 days, neither MnSOD nor CuZnSOD were affected by olive oil. The different effects of olive oil on the brain SOD, during ontogeny suggest that profound changes in the susceptibility of nervous tissue antioxidant enzymes to olive oil take place during sexual maturation.
T2  - Physiological Research
T1  - Effects of olive oil on superoxide dismutase activity in the brain of newborn and young female rats
VL  - 48
IS  - 4
SP  - 297
EP  - 301
UR  - https://hdl.handle.net/21.15107/rcub_vinar_2283
ER  - 

@article{
author = "Pejić, Snežana and Kasapović, Jelena and Pajović, Snežana B.",
year = "1999",
abstract = "Changes in the activity of brain antioxidant superoxide dismutases (SOD) were followed in newborn and young female rats 8, 15, 30, 45, 60 and 75 days after birth treated with olive oil. In newborn rats, the content of brain cytosol SOD (CuZnSOD) and mitochondrial SOD (MnSOD) decreased after treatment with olive oil. However, in the brain of rats aged 8 days this effect was lost. The suppressive effect of olive oil on these enzymes reappeared again in 15-day-old rats. In rats aged one month, only the activity of CuZnSOD was reduced after olive oil treatment. In the brain of rats aged 45, 60 and 75 days, neither MnSOD nor CuZnSOD were affected by olive oil. The different effects of olive oil on the brain SOD, during ontogeny suggest that profound changes in the susceptibility of nervous tissue antioxidant enzymes to olive oil take place during sexual maturation.",
journal = "Physiological Research",
title = "Effects of olive oil on superoxide dismutase activity in the brain of newborn and young female rats",
volume = "48",
number = "4",
pages = "297-301",
url = "https://hdl.handle.net/21.15107/rcub_vinar_2283"
}

Pejić, S., Kasapović, J.,& Pajović, S. B.. (1999). Effects of olive oil on superoxide dismutase activity in the brain of newborn and young female rats. in Physiological Research, 48(4), 297-301.
https://hdl.handle.net/21.15107/rcub_vinar_2283

Pejić S, Kasapović J, Pajović SB. Effects of olive oil on superoxide dismutase activity in the brain of newborn and young female rats. in Physiological Research. 1999;48(4):297-301.
https://hdl.handle.net/21.15107/rcub_vinar_2283 .

Pejić, Snežana, Kasapović, Jelena, Pajović, Snežana B., "Effects of olive oil on superoxide dismutase activity in the brain of newborn and young female rats" in Physiological Research, 48, no. 4 (1999):297-301,
https://hdl.handle.net/21.15107/rcub_vinar_2283 .