TY  - JOUR
AU  - Kalauzi, Aleksandar
AU  - Matić, Zoran
AU  - Platiša, Mirjana M.
AU  - Bojić, Tijana
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10708
AB  - Due to the fact that respiratory breath-to-breath and cardiac intervals between two successive R peaks (BBI and RRI, respectively) are not temporally concurrent, in a previous paper, we proposed a method to calculate both the integer and non-integer parts of the pulse respiration quotient (PRQ = BBI/RRI = PRQint + b1 + b2), b1 and b2 being parts of the border RRIs for each BBI. In this work, we study the correlations between BBI and PRQ, as well as those between BBI and mean RRI within each BBI (mRRI), on a group of twenty subjects in four conditions: in supine and standing positions, in combination with spontaneous and slow breathing. Results show that the BBI vs. PRQ correlations are positive; whereas the breathing regime had little or no effect on the linear regression slopes, body posture did. Two types of scatter plots were obtained with the BBI vs. mRRI correlations: one showed points aggregated around the concurrent PRQint lines, while the other showed randomly distributed points. Five out of six of the proposed aggregation measures confirmed the existence of these two cardio-respiratory coupling regimes. We also used b1 to study the positions of R pulses relative to the respiration onsets and showed that they were more synchronous with sympathetic activation. Overall, this method should be used in different pathological states.
T2  - Bioengineering
T1  - Two Operational Modes of Cardio-Respiratory Coupling Revealed by Pulse-Respiration Quotient
VL  - 10
IS  - 2
SP  - 180
DO  - 10.3390/bioengineering10020180
ER  - 

@article{
author = "Kalauzi, Aleksandar and Matić, Zoran and Platiša, Mirjana M. and Bojić, Tijana",
year = "2023",
abstract = "Due to the fact that respiratory breath-to-breath and cardiac intervals between two successive R peaks (BBI and RRI, respectively) are not temporally concurrent, in a previous paper, we proposed a method to calculate both the integer and non-integer parts of the pulse respiration quotient (PRQ = BBI/RRI = PRQint + b1 + b2), b1 and b2 being parts of the border RRIs for each BBI. In this work, we study the correlations between BBI and PRQ, as well as those between BBI and mean RRI within each BBI (mRRI), on a group of twenty subjects in four conditions: in supine and standing positions, in combination with spontaneous and slow breathing. Results show that the BBI vs. PRQ correlations are positive; whereas the breathing regime had little or no effect on the linear regression slopes, body posture did. Two types of scatter plots were obtained with the BBI vs. mRRI correlations: one showed points aggregated around the concurrent PRQint lines, while the other showed randomly distributed points. Five out of six of the proposed aggregation measures confirmed the existence of these two cardio-respiratory coupling regimes. We also used b1 to study the positions of R pulses relative to the respiration onsets and showed that they were more synchronous with sympathetic activation. Overall, this method should be used in different pathological states.",
journal = "Bioengineering",
title = "Two Operational Modes of Cardio-Respiratory Coupling Revealed by Pulse-Respiration Quotient",
volume = "10",
number = "2",
pages = "180",
doi = "10.3390/bioengineering10020180"
}

Kalauzi, A., Matić, Z., Platiša, M. M.,& Bojić, T.. (2023). Two Operational Modes of Cardio-Respiratory Coupling Revealed by Pulse-Respiration Quotient. in Bioengineering, 10(2), 180.
https://doi.org/10.3390/bioengineering10020180

Kalauzi A, Matić Z, Platiša MM, Bojić T. Two Operational Modes of Cardio-Respiratory Coupling Revealed by Pulse-Respiration Quotient. in Bioengineering. 2023;10(2):180.
doi:10.3390/bioengineering10020180 .

Kalauzi, Aleksandar, Matić, Zoran, Platiša, Mirjana M., Bojić, Tijana, "Two Operational Modes of Cardio-Respiratory Coupling Revealed by Pulse-Respiration Quotient" in Bioengineering, 10, no. 2 (2023):180,
https://doi.org/10.3390/bioengineering10020180 . .

TY  - JOUR
AU  - Kalauzi, Aleksandar
AU  - Matić, Zoran
AU  - Bojić, Tijana
AU  - Platiša, Mirjana M.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10507
AB  - ObjectivesIn order to reveal their structure, Poincaré plots (PP) of electrocardiogram (ECG) RR intervals (RRI) were studied as linear edge planar directed graphs, obtained by connecting all their sequential points. We were also aimed at studying their graph complexity properties.MethodsRRI signals were subjected to a series of different window length (WL) Moving Average Low Pass (MALP) filters. For each filtered graph, four standard PP descriptors: Pearson’s coefficient, SD1, SD2, and SD2/SD1 were calculated, as well as four new graph complexity measures: mean angle between adjacent graph edges; mean number of edge crossings; directional complexity and directional entropy. This approach was applied to signals of twenty young healthy subjects, recorded in four experimental conditions – combination of two body postures (supine and standing) and two breathing regimes (spontaneous and slow 0.1 Hz).ResultsWe found that PP graphs consist of two superimposed components: one originating from Respiratory Sinus Arrhythmia (RSA) oscillations, the other from slow variations (SV) of the RRI time series. This result was further corroborated by observing the transformation of a PP cloud shape occurring in filtered graphs. When applied to subjects, the outcome was that three measures significantly differentiated the two breathing regimes in the RSA region of the WL domain, while four other measures were able to differentiate two body postures in the SV WL region.DiscussionAfter obtaining these results in healthy, we expect to successfully apply this approach to patients suffering from different pathological conditions.
T2  - Biomedical Signal Processing and Control
T1  - Structure of Poincaré plots revealed by their graph analysis and low pass filtering of the RRI time series
VL  - 80
SP  - 104352
DO  - 10.1016/j.bspc.2022.104352
ER  - 

@article{
author = "Kalauzi, Aleksandar and Matić, Zoran and Bojić, Tijana and Platiša, Mirjana M.",
year = "2023",
abstract = "ObjectivesIn order to reveal their structure, Poincaré plots (PP) of electrocardiogram (ECG) RR intervals (RRI) were studied as linear edge planar directed graphs, obtained by connecting all their sequential points. We were also aimed at studying their graph complexity properties.MethodsRRI signals were subjected to a series of different window length (WL) Moving Average Low Pass (MALP) filters. For each filtered graph, four standard PP descriptors: Pearson’s coefficient, SD1, SD2, and SD2/SD1 were calculated, as well as four new graph complexity measures: mean angle between adjacent graph edges; mean number of edge crossings; directional complexity and directional entropy. This approach was applied to signals of twenty young healthy subjects, recorded in four experimental conditions – combination of two body postures (supine and standing) and two breathing regimes (spontaneous and slow 0.1 Hz).ResultsWe found that PP graphs consist of two superimposed components: one originating from Respiratory Sinus Arrhythmia (RSA) oscillations, the other from slow variations (SV) of the RRI time series. This result was further corroborated by observing the transformation of a PP cloud shape occurring in filtered graphs. When applied to subjects, the outcome was that three measures significantly differentiated the two breathing regimes in the RSA region of the WL domain, while four other measures were able to differentiate two body postures in the SV WL region.DiscussionAfter obtaining these results in healthy, we expect to successfully apply this approach to patients suffering from different pathological conditions.",
journal = "Biomedical Signal Processing and Control",
title = "Structure of Poincaré plots revealed by their graph analysis and low pass filtering of the RRI time series",
volume = "80",
pages = "104352",
doi = "10.1016/j.bspc.2022.104352"
}

Kalauzi, A., Matić, Z., Bojić, T.,& Platiša, M. M.. (2023). Structure of Poincaré plots revealed by their graph analysis and low pass filtering of the RRI time series. in Biomedical Signal Processing and Control, 80, 104352.
https://doi.org/10.1016/j.bspc.2022.104352

Kalauzi A, Matić Z, Bojić T, Platiša MM. Structure of Poincaré plots revealed by their graph analysis and low pass filtering of the RRI time series. in Biomedical Signal Processing and Control. 2023;80:104352.
doi:10.1016/j.bspc.2022.104352 .

Kalauzi, Aleksandar, Matić, Zoran, Bojić, Tijana, Platiša, Mirjana M., "Structure of Poincaré plots revealed by their graph analysis and low pass filtering of the RRI time series" in Biomedical Signal Processing and Control, 80 (2023):104352,
https://doi.org/10.1016/j.bspc.2022.104352 . .

TY  - JOUR
AU  - Bojić, Tijana
AU  - Senćanski, Milan V.
AU  - Perović, Vladimir R.
AU  - Milićević, Jelena S.
AU  - Glišić, Sanja
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10252
AB  - Alzheimer’s disease (AD), a devastating neurodegenerative disease, is the focus of pharmacological research. One of the targets that attract the most attention for the potential therapy of AD is the serotonin 5HT6 receptor, which is the receptor situated exclusively in CNS on glutamatergic and GABAergic neurons. The neurochemical impact of this receptor supports the hypothesis about its role in cognitive, learning, and memory systems, which are of critical importance for AD. Natural products are a promising source of novel bioactive compounds with potential therapeutic potential as a 5HT6 receptor antagonist in the treatment of AD dementia. The ZINC—natural product database was in silico screened in order to find the candidate antagonists of 5-HT6 receptor against AD. A virtual screening protocol that includes both short-and long-range interactions between interacting molecules was employed. First, the EIIP/AQVN filter was applied for in silico screening of the ZINC database followed by 3D QSAR and molecular docking. Ten best candidate compounds were selected from the ZINC Natural Product database as potential 5HT6 Receptor antagonists and were proposed for further evaluation. The best candidate was evaluated by molecular dynamics simulations and free energy calculations.
T2  - Molecules
T1  - In Silico Screening of Natural Compounds for Candidates 5HT6 Receptor Antagonists against Alzheimer’s Disease
VL  - 27
IS  - 9
SP  - 2626
DO  - 10.3390/molecules27092626
ER  - 

@article{
author = "Bojić, Tijana and Senćanski, Milan V. and Perović, Vladimir R. and Milićević, Jelena S. and Glišić, Sanja",
year = "2022",
abstract = "Alzheimer’s disease (AD), a devastating neurodegenerative disease, is the focus of pharmacological research. One of the targets that attract the most attention for the potential therapy of AD is the serotonin 5HT6 receptor, which is the receptor situated exclusively in CNS on glutamatergic and GABAergic neurons. The neurochemical impact of this receptor supports the hypothesis about its role in cognitive, learning, and memory systems, which are of critical importance for AD. Natural products are a promising source of novel bioactive compounds with potential therapeutic potential as a 5HT6 receptor antagonist in the treatment of AD dementia. The ZINC—natural product database was in silico screened in order to find the candidate antagonists of 5-HT6 receptor against AD. A virtual screening protocol that includes both short-and long-range interactions between interacting molecules was employed. First, the EIIP/AQVN filter was applied for in silico screening of the ZINC database followed by 3D QSAR and molecular docking. Ten best candidate compounds were selected from the ZINC Natural Product database as potential 5HT6 Receptor antagonists and were proposed for further evaluation. The best candidate was evaluated by molecular dynamics simulations and free energy calculations.",
journal = "Molecules",
title = "In Silico Screening of Natural Compounds for Candidates 5HT6 Receptor Antagonists against Alzheimer’s Disease",
volume = "27",
number = "9",
pages = "2626",
doi = "10.3390/molecules27092626"
}

Bojić, T., Senćanski, M. V., Perović, V. R., Milićević, J. S.,& Glišić, S.. (2022). In Silico Screening of Natural Compounds for Candidates 5HT6 Receptor Antagonists against Alzheimer’s Disease. in Molecules, 27(9), 2626.
https://doi.org/10.3390/molecules27092626

Bojić T, Senćanski MV, Perović VR, Milićević JS, Glišić S. In Silico Screening of Natural Compounds for Candidates 5HT6 Receptor Antagonists against Alzheimer’s Disease. in Molecules. 2022;27(9):2626.
doi:10.3390/molecules27092626 .

Bojić, Tijana, Senćanski, Milan V., Perović, Vladimir R., Milićević, Jelena S., Glišić, Sanja, "In Silico Screening of Natural Compounds for Candidates 5HT6 Receptor Antagonists against Alzheimer’s Disease" in Molecules, 27, no. 9 (2022):2626,
https://doi.org/10.3390/molecules27092626 . .

TY  - CONF
AU  - Matić, Zoran
AU  - Kalauzi, Aleksandar
AU  - Platiša, Mirjana M.
AU  - Bojić, Tijana
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10513
AB  - It has become common in research with detrended fluctuation analysis (DFA) to use slopes of regression lines (α1 and α2) and their ratio as measures of fractal properties of dynamical processes such as physiological rhythm fluctuations. In this study, instead of the ratio (α1/α2) in DFA of ECG RR intervals and respiratory signals, we propose the use of a new measure: the inter-fractal angle (θ) - angle that DFA regression lines form between each other. Methods. Angle θ was obtained by means of graphical-analytical calculation. Using one way-Anova test, sensitivity of θ on the influence of slow breathing and orthostasis was compared in respect to ratio α1/α2. Results. Comparisons revealed that changes of (θ) were statistically more significant than changes of αl/α2. Conclusion. Inter-fractal angle is an elegant new measure of DFA that is more sensitive to perturbations such as changes in body posture and breathing regime than α1/α2.
C3  - 2022 12th Conference of the European Study Group on Cardiovascular Oscillations (ESGCO)
T1  - Sensitivity Estimations in Favor of Using Inter-fractal Angle in Detrended Fluctuation Analysis
SP  - 1
EP  - 2
DO  - 10.1109/ESGCO55423.2022.9931387
ER  - 

@conference{
author = "Matić, Zoran and Kalauzi, Aleksandar and Platiša, Mirjana M. and Bojić, Tijana",
year = "2022",
abstract = "It has become common in research with detrended fluctuation analysis (DFA) to use slopes of regression lines (α1 and α2) and their ratio as measures of fractal properties of dynamical processes such as physiological rhythm fluctuations. In this study, instead of the ratio (α1/α2) in DFA of ECG RR intervals and respiratory signals, we propose the use of a new measure: the inter-fractal angle (θ) - angle that DFA regression lines form between each other. Methods. Angle θ was obtained by means of graphical-analytical calculation. Using one way-Anova test, sensitivity of θ on the influence of slow breathing and orthostasis was compared in respect to ratio α1/α2. Results. Comparisons revealed that changes of (θ) were statistically more significant than changes of αl/α2. Conclusion. Inter-fractal angle is an elegant new measure of DFA that is more sensitive to perturbations such as changes in body posture and breathing regime than α1/α2.",
journal = "2022 12th Conference of the European Study Group on Cardiovascular Oscillations (ESGCO)",
title = "Sensitivity Estimations in Favor of Using Inter-fractal Angle in Detrended Fluctuation Analysis",
pages = "1-2",
doi = "10.1109/ESGCO55423.2022.9931387"
}

Matić, Z., Kalauzi, A., Platiša, M. M.,& Bojić, T.. (2022). Sensitivity Estimations in Favor of Using Inter-fractal Angle in Detrended Fluctuation Analysis. in 2022 12th Conference of the European Study Group on Cardiovascular Oscillations (ESGCO), 1-2.
https://doi.org/10.1109/ESGCO55423.2022.9931387

Matić Z, Kalauzi A, Platiša MM, Bojić T. Sensitivity Estimations in Favor of Using Inter-fractal Angle in Detrended Fluctuation Analysis. in 2022 12th Conference of the European Study Group on Cardiovascular Oscillations (ESGCO). 2022;:1-2.
doi:10.1109/ESGCO55423.2022.9931387 .

Matić, Zoran, Kalauzi, Aleksandar, Platiša, Mirjana M., Bojić, Tijana, "Sensitivity Estimations in Favor of Using Inter-fractal Angle in Detrended Fluctuation Analysis" in 2022 12th Conference of the European Study Group on Cardiovascular Oscillations (ESGCO) (2022):1-2,
https://doi.org/10.1109/ESGCO55423.2022.9931387 . .

TY  - JOUR
AU  - Matić, Zoran
AU  - Kalauzi, Aleksandar
AU  - Moser, Maximilian
AU  - Platiša, Mirjana M.
AU  - Lazarević, Mihailo
AU  - Bojić, Tijana
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10599
AB  - In this research we explored the (homeo)dynamic character of cardiorespiratory coupling (CRC) under the influence of different body posture and breathing regimes. Our tool for it was the pulse respiration quotient (PRQ), representing the number of heartbeat intervals per breathing cycle. We obtained non-integer PRQ values using our advanced Matlab® algorithm and applied it on the signals of 20 healthy subjects in four conditions: supine position with spontaneous breathing (Supin), standing with spontaneous breathing (Stand), supine position with slow (0.1 Hz) breathing (Supin01) and standing with slow (0.1 Hz) breathing (Stand01).Main results: Linear features of CRC (in PRQ signals) were dynamically very sensitive to posture and breathing rhythm perturbations. There are obvious increases in PRQ mean level and variability under the separated and joined influence of orthostasis and slow (0.1 Hz) breathing. This increase was most pronounced in Stand01 as the state of joint influences. Importantly, PRQ dynamic modification showed greater sensitivity to body posture and breathing regime changes than mean value and standard deviation of heart rhythm and breathing rhythm. In addition, as a consequence of prolonged supine position, we noticed the tendency to integer quantization of PRQ (especially after 14 min), in which the most common quantization number was 4:1 (demonstrated in other research reports as well). In orthostasis and slow breathing, quantization can also be observed, but shifted to other values. We postulate that these results manifest resonance effects induced by coupling patterns from sympathetic and parasympathetic adjustments (with the second as dominant factor).Significance: Our research confirms that cardiorespiratory coupling adaptability could be profoundly explored by precisely calculated PRQ parameter since cardiorespiratory regulation in healthy subjects is characterized by a high level of autonomic adaptability (responsiveness) to posture and breathing regime, although comparisons with pathological states has yet to be performed. We found Stand01 to be the most provoking state for the dynamic modification of PRQ (cardiorespiratory inducement). As such, Stand01 has the potential of using for PRQ tuning by conditioning the cardiorespiratory autonomic neural networks, e.g., in the cases where PRQ is disturbed by environmental (i.e., microgravity) or pathologic conditions.
T2  - Frontiers in Physiology
T1  - Pulse respiration quotient as a measure sensitive to changes in dynamic behavior of cardiorespiratory coupling such as body posture and breathing regime
VL  - 13
DO  - 10.3389/fphys.2022.946613
ER  - 

@article{
author = "Matić, Zoran and Kalauzi, Aleksandar and Moser, Maximilian and Platiša, Mirjana M. and Lazarević, Mihailo and Bojić, Tijana",
year = "2022",
abstract = "In this research we explored the (homeo)dynamic character of cardiorespiratory coupling (CRC) under the influence of different body posture and breathing regimes. Our tool for it was the pulse respiration quotient (PRQ), representing the number of heartbeat intervals per breathing cycle. We obtained non-integer PRQ values using our advanced Matlab® algorithm and applied it on the signals of 20 healthy subjects in four conditions: supine position with spontaneous breathing (Supin), standing with spontaneous breathing (Stand), supine position with slow (0.1 Hz) breathing (Supin01) and standing with slow (0.1 Hz) breathing (Stand01).Main results: Linear features of CRC (in PRQ signals) were dynamically very sensitive to posture and breathing rhythm perturbations. There are obvious increases in PRQ mean level and variability under the separated and joined influence of orthostasis and slow (0.1 Hz) breathing. This increase was most pronounced in Stand01 as the state of joint influences. Importantly, PRQ dynamic modification showed greater sensitivity to body posture and breathing regime changes than mean value and standard deviation of heart rhythm and breathing rhythm. In addition, as a consequence of prolonged supine position, we noticed the tendency to integer quantization of PRQ (especially after 14 min), in which the most common quantization number was 4:1 (demonstrated in other research reports as well). In orthostasis and slow breathing, quantization can also be observed, but shifted to other values. We postulate that these results manifest resonance effects induced by coupling patterns from sympathetic and parasympathetic adjustments (with the second as dominant factor).Significance: Our research confirms that cardiorespiratory coupling adaptability could be profoundly explored by precisely calculated PRQ parameter since cardiorespiratory regulation in healthy subjects is characterized by a high level of autonomic adaptability (responsiveness) to posture and breathing regime, although comparisons with pathological states has yet to be performed. We found Stand01 to be the most provoking state for the dynamic modification of PRQ (cardiorespiratory inducement). As such, Stand01 has the potential of using for PRQ tuning by conditioning the cardiorespiratory autonomic neural networks, e.g., in the cases where PRQ is disturbed by environmental (i.e., microgravity) or pathologic conditions.",
journal = "Frontiers in Physiology",
title = "Pulse respiration quotient as a measure sensitive to changes in dynamic behavior of cardiorespiratory coupling such as body posture and breathing regime",
volume = "13",
doi = "10.3389/fphys.2022.946613"
}

Matić, Z., Kalauzi, A., Moser, M., Platiša, M. M., Lazarević, M.,& Bojić, T.. (2022). Pulse respiration quotient as a measure sensitive to changes in dynamic behavior of cardiorespiratory coupling such as body posture and breathing regime. in Frontiers in Physiology, 13.
https://doi.org/10.3389/fphys.2022.946613

Matić Z, Kalauzi A, Moser M, Platiša MM, Lazarević M, Bojić T. Pulse respiration quotient as a measure sensitive to changes in dynamic behavior of cardiorespiratory coupling such as body posture and breathing regime. in Frontiers in Physiology. 2022;13.
doi:10.3389/fphys.2022.946613 .

Matić, Zoran, Kalauzi, Aleksandar, Moser, Maximilian, Platiša, Mirjana M., Lazarević, Mihailo, Bojić, Tijana, "Pulse respiration quotient as a measure sensitive to changes in dynamic behavior of cardiorespiratory coupling such as body posture and breathing regime" in Frontiers in Physiology, 13 (2022),
https://doi.org/10.3389/fphys.2022.946613 . .

TY  - JOUR
AU  - Matić, Zoran
AU  - Bojić, Tijana
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8865
T2  - Vojnosanitetski pregled
T1  - Acupuncture, autonomic nervous system and biophysical origin of acupuncture system
VL  - 77
IS  - 1
SP  - 79
EP  - 86
DO  - 10.2298/VSP170818016M
ER  - 

@article{
author = "Matić, Zoran and Bojić, Tijana",
year = "2020",
journal = "Vojnosanitetski pregled",
title = "Acupuncture, autonomic nervous system and biophysical origin of acupuncture system",
volume = "77",
number = "1",
pages = "79-86",
doi = "10.2298/VSP170818016M"
}

Matić, Z.,& Bojić, T.. (2020). Acupuncture, autonomic nervous system and biophysical origin of acupuncture system. in Vojnosanitetski pregled, 77(1), 79-86.
https://doi.org/10.2298/VSP170818016M

Matić Z, Bojić T. Acupuncture, autonomic nervous system and biophysical origin of acupuncture system. in Vojnosanitetski pregled. 2020;77(1):79-86.
doi:10.2298/VSP170818016M .

Matić, Zoran, Bojić, Tijana, "Acupuncture, autonomic nervous system and biophysical origin of acupuncture system" in Vojnosanitetski pregled, 77, no. 1 (2020):79-86,
https://doi.org/10.2298/VSP170818016M . .

TY  - JOUR
AU  - Matić, Zoran
AU  - Platiša, Mirjana M.
AU  - Kalauzi, Aleksandar
AU  - Bojić, Tijana
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8848
AB  - Objective: We explored the physiological background of the non-linear operating mode of cardiorespiratory oscillators as the fundamental question of cardiorespiratory homeodynamics and as a prerequisite for the understanding of neurocardiovascular diseases. We investigated 20 healthy human subjects for changes using electrocardiac RR interval (RRI) and respiratory signal (Resp) Detrended Fluctuation Analysis (DFA, α1RRI, α2RRI, α1Resp, α2Resp), Multiple Scaling Entropy (MSERRI1−4, MSERRI5−10, MSEResp1−4, MSEResp5−10), spectral coherence (CohRRI−Resp), cross DFA (ρ1 and ρ2) and cross MSE (XMSE1−4 and XMSE5−10) indices in four physiological conditions: supine with spontaneous breathing, standing with spontaneous breathing, supine with 0.1 Hz breathing and standing with 0.1 Hz breathing. Main results: Standing is primarily characterized by the change of RRI parameters, insensitivity to change with respiratory parameters, decrease of CohRRI−Resp and insensitivity to change of in ρ1, ρ2, XMSE1−4, and XMSE5−10. Slow breathing in supine position was characterized by the change of the linear and non-linear parameters of both signals, reflecting the dominant vagal RRI modulation and the impact of slow 0.1 Hz breathing on Resp parameters. CohRRI−Resp did not change with respect to supine position, while ρ1 increased. Slow breathing in standing reflected the qualitatively specific state of autonomic regulation with striking impact on both cardiac and respiratory parameters, with specific patterns of cardiorespiratory coupling. Significance: Our results show that cardiac and respiratory short term and long term complexity parameters have different, state dependent patterns. Sympathovagal non-linear interactions are dependent on the pattern of their activation, having different scaling properties when individually activated with respect to the state of their joint activation. All investigated states induced a change of α1 vs. α2 relationship, which can be accurately expressed by the proposed measure—inter-fractal angle θ. Short scale (α1 vs. MSE1−4) and long scale (α2 vs. MSE5−10) complexity measures had reciprocal interrelation in standing with 0.1 Hz breathing, with specific cardiorespiratory coupling pattern (ρ1 vs. XMSE1−4). These results support the hypothesis of hierarchical organization of cardiorespiratory complexity mechanisms and their recruitment in ascendant manner with respect to the increase of behavioral challenge complexity. Specific and comprehensive cardiorespiratory regulation in standing with 0.1 Hz breathing suggests this state as the potentially most beneficial maneuver for cardiorespiratory conditioning. © Copyright © 2020 Matić, Platiša, Kalauzi and Bojić.
T2  - Frontiers in Physiology
T1  - Slow 0.1 Hz Breathing and Body Posture Induced Perturbations of RRI and Respiratory Signal Complexity and Cardiorespiratory Coupling
VL  - 11
SP  - 24
DO  - 10.3389/fphys.2020.00024
ER  - 

@article{
author = "Matić, Zoran and Platiša, Mirjana M. and Kalauzi, Aleksandar and Bojić, Tijana",
year = "2020",
abstract = "Objective: We explored the physiological background of the non-linear operating mode of cardiorespiratory oscillators as the fundamental question of cardiorespiratory homeodynamics and as a prerequisite for the understanding of neurocardiovascular diseases. We investigated 20 healthy human subjects for changes using electrocardiac RR interval (RRI) and respiratory signal (Resp) Detrended Fluctuation Analysis (DFA, α1RRI, α2RRI, α1Resp, α2Resp), Multiple Scaling Entropy (MSERRI1−4, MSERRI5−10, MSEResp1−4, MSEResp5−10), spectral coherence (CohRRI−Resp), cross DFA (ρ1 and ρ2) and cross MSE (XMSE1−4 and XMSE5−10) indices in four physiological conditions: supine with spontaneous breathing, standing with spontaneous breathing, supine with 0.1 Hz breathing and standing with 0.1 Hz breathing. Main results: Standing is primarily characterized by the change of RRI parameters, insensitivity to change with respiratory parameters, decrease of CohRRI−Resp and insensitivity to change of in ρ1, ρ2, XMSE1−4, and XMSE5−10. Slow breathing in supine position was characterized by the change of the linear and non-linear parameters of both signals, reflecting the dominant vagal RRI modulation and the impact of slow 0.1 Hz breathing on Resp parameters. CohRRI−Resp did not change with respect to supine position, while ρ1 increased. Slow breathing in standing reflected the qualitatively specific state of autonomic regulation with striking impact on both cardiac and respiratory parameters, with specific patterns of cardiorespiratory coupling. Significance: Our results show that cardiac and respiratory short term and long term complexity parameters have different, state dependent patterns. Sympathovagal non-linear interactions are dependent on the pattern of their activation, having different scaling properties when individually activated with respect to the state of their joint activation. All investigated states induced a change of α1 vs. α2 relationship, which can be accurately expressed by the proposed measure—inter-fractal angle θ. Short scale (α1 vs. MSE1−4) and long scale (α2 vs. MSE5−10) complexity measures had reciprocal interrelation in standing with 0.1 Hz breathing, with specific cardiorespiratory coupling pattern (ρ1 vs. XMSE1−4). These results support the hypothesis of hierarchical organization of cardiorespiratory complexity mechanisms and their recruitment in ascendant manner with respect to the increase of behavioral challenge complexity. Specific and comprehensive cardiorespiratory regulation in standing with 0.1 Hz breathing suggests this state as the potentially most beneficial maneuver for cardiorespiratory conditioning. © Copyright © 2020 Matić, Platiša, Kalauzi and Bojić.",
journal = "Frontiers in Physiology",
title = "Slow 0.1 Hz Breathing and Body Posture Induced Perturbations of RRI and Respiratory Signal Complexity and Cardiorespiratory Coupling",
volume = "11",
pages = "24",
doi = "10.3389/fphys.2020.00024"
}

Matić, Z., Platiša, M. M., Kalauzi, A.,& Bojić, T.. (2020). Slow 0.1 Hz Breathing and Body Posture Induced Perturbations of RRI and Respiratory Signal Complexity and Cardiorespiratory Coupling. in Frontiers in Physiology, 11, 24.
https://doi.org/10.3389/fphys.2020.00024

Matić Z, Platiša MM, Kalauzi A, Bojić T. Slow 0.1 Hz Breathing and Body Posture Induced Perturbations of RRI and Respiratory Signal Complexity and Cardiorespiratory Coupling. in Frontiers in Physiology. 2020;11:24.
doi:10.3389/fphys.2020.00024 .

Matić, Zoran, Platiša, Mirjana M., Kalauzi, Aleksandar, Bojić, Tijana, "Slow 0.1 Hz Breathing and Body Posture Induced Perturbations of RRI and Respiratory Signal Complexity and Cardiorespiratory Coupling" in Frontiers in Physiology, 11 (2020):24,
https://doi.org/10.3389/fphys.2020.00024 . .

TY  - JOUR
AU  - Bojić, Tijana
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8179
T2  - Frontiers in Neuroscience
T1  - Editorial: Neurocardiovascular Diseases: New Aspects of the Old Issues
VL  - 12
IS  - JAN
DO  - 10.3389/fnins.2018.01032
ER  - 

@article{
author = "Bojić, Tijana",
year = "2019",
journal = "Frontiers in Neuroscience",
title = "Editorial: Neurocardiovascular Diseases: New Aspects of the Old Issues",
volume = "12",
number = "JAN",
doi = "10.3389/fnins.2018.01032"
}

Bojić, T.. (2019). Editorial: Neurocardiovascular Diseases: New Aspects of the Old Issues. in Frontiers in Neuroscience, 12(JAN).
https://doi.org/10.3389/fnins.2018.01032

Bojić T. Editorial: Neurocardiovascular Diseases: New Aspects of the Old Issues. in Frontiers in Neuroscience. 2019;12(JAN).
doi:10.3389/fnins.2018.01032 .

Bojić, Tijana, "Editorial: Neurocardiovascular Diseases: New Aspects of the Old Issues" in Frontiers in Neuroscience, 12, no. JAN (2019),
https://doi.org/10.3389/fnins.2018.01032 . .

TY  - JOUR
AU  - Platiša, Mirjana M.
AU  - Bojić, Tijana
AU  - Mazić, Sanja D.
AU  - Kalauzi, Aleksandar
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8413
AB  - Background Recently we proposed a new method called generalized Poincare´ plot (gPp) analysis which gave a new insight into the pattern of neurocaridac control. In this study we examined potential of gPp method to reveal changes in cardiac neural control in young athletes during three conditions: supine rest, running and relaxation, with respect to untrained subjects. Methods This method is based on the quantification of Pearson's correlation coefficients r(j, k), between symmetrical (j = k) and asymmetrical summed j previous and k following RR intervals up to the 100th order (j,k.100). Results Differences between groups were obtained at all levels of this analysis. The main result is the significant difference of NAI, normalized index of asymmetry, between groups in running, which was originated in different positions of local maxima of r(j, k). Compared with untrained subjects, these findings indicate modified neural control and altered intrinsic heart rate behavior in athletes which are related to some kind of memory mechanism between RR intervals. Conclusion Obtained results provide great potential of gPp method analysis in the recognition of changes in neurocardiac control in healthy subjects. Further studies are needed for identification of altered cardiac regulatory mechanisms whose background may be useful in the evaluation of genesis of athletes neurocardiovascular pathology. © 2019 Platiša et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
T2  - PLOS One
T1  - Generalized Poincaré plots analysis of heart period dynamics in different physiological conditions: Trained vs. untrained men
VL  - 14
IS  - 7
SP  - e0219281
DO  - 10.1371/journal.pone.0219281
ER  - 

@article{
author = "Platiša, Mirjana M. and Bojić, Tijana and Mazić, Sanja D. and Kalauzi, Aleksandar",
year = "2019",
abstract = "Background Recently we proposed a new method called generalized Poincare´ plot (gPp) analysis which gave a new insight into the pattern of neurocaridac control. In this study we examined potential of gPp method to reveal changes in cardiac neural control in young athletes during three conditions: supine rest, running and relaxation, with respect to untrained subjects. Methods This method is based on the quantification of Pearson's correlation coefficients r(j, k), between symmetrical (j = k) and asymmetrical summed j previous and k following RR intervals up to the 100th order (j,k.100). Results Differences between groups were obtained at all levels of this analysis. The main result is the significant difference of NAI, normalized index of asymmetry, between groups in running, which was originated in different positions of local maxima of r(j, k). Compared with untrained subjects, these findings indicate modified neural control and altered intrinsic heart rate behavior in athletes which are related to some kind of memory mechanism between RR intervals. Conclusion Obtained results provide great potential of gPp method analysis in the recognition of changes in neurocardiac control in healthy subjects. Further studies are needed for identification of altered cardiac regulatory mechanisms whose background may be useful in the evaluation of genesis of athletes neurocardiovascular pathology. © 2019 Platiša et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",
journal = "PLOS One",
title = "Generalized Poincaré plots analysis of heart period dynamics in different physiological conditions: Trained vs. untrained men",
volume = "14",
number = "7",
pages = "e0219281",
doi = "10.1371/journal.pone.0219281"
}

Platiša, M. M., Bojić, T., Mazić, S. D.,& Kalauzi, A.. (2019). Generalized Poincaré plots analysis of heart period dynamics in different physiological conditions: Trained vs. untrained men. in PLOS One, 14(7), e0219281.
https://doi.org/10.1371/journal.pone.0219281

Platiša MM, Bojić T, Mazić SD, Kalauzi A. Generalized Poincaré plots analysis of heart period dynamics in different physiological conditions: Trained vs. untrained men. in PLOS One. 2019;14(7):e0219281.
doi:10.1371/journal.pone.0219281 .

Platiša, Mirjana M., Bojić, Tijana, Mazić, Sanja D., Kalauzi, Aleksandar, "Generalized Poincaré plots analysis of heart period dynamics in different physiological conditions: Trained vs. untrained men" in PLOS One, 14, no. 7 (2019):e0219281,
https://doi.org/10.1371/journal.pone.0219281 . .

TY  - JOUR
AU  - Stanojević, Boban
AU  - Đukić, Mirjana
AU  - Stevanović, Ivana
AU  - Ninković, Milica
AU  - Đurić, Ana
AU  - Gobeljić, Borko
AU  - Apostolović, Milan
AU  - Pantelić, Ana
AU  - Zebić, Goran
AU  - Todorović, Lidija
AU  - Bojić, Tijana
AU  - Savovski, Kiril
PY  - 2018
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8863
AB  - The aim of our study was to test the effect of subacutely applied micronized zeolite [micronized clinoptilolite (MZC)] on brain status of iron (Fe), reactive oxygen and nitrogen species (ROS, RNS), and radioprotective role against brain oxidative/nitrosative stress (OS/NS) initiated by single ionizing radiation of 2 or 10Gray (Gy). Wistar rats on normal (n=18) and 5% MZC supplemented diet (n=18), during 4 weeks, were internally subdivided into 3 subgroups (6 rats in each subgroup), with one of subgroup remaining as a control, and the other two subjected to single ionizing radiation of 2Gy or 10Gy. Thus, we had groups on normal diet: C – controls, 2Gy and 10Gy; and on 5% MZC supplemented diet: MZC, MZC+2Gy and MZC+10Gy. Concentrations of nitrates (a final RNS metabolite) and superoxide anion radical (O2 •-) (an initial ROS) were measured in homogenates of selective vulnerable brain regions (cerebellum, hippocampus and forebrain cortex), while Fe was determined in whole brain of rats. Results documented a significant drop of Fe in MZC and MZC+2Gy/10Gy groups; decrease of O2 •- and nitrate in MZC group; almost equal drop of O2 •- , in 2Gy and MZC+2Gy groups; and nitrate increase in 10Gy and MZC+10Gy groups. We confirmed that subacute MZC pretreatment contributes to partially accomplished brain radioprotective effect in rats exposed to single radiation dose of 2Gy and 10Gy, probably due to reduced OS/NS and Fe.
T2  - Hrana i ishrana
T1  - Zeolite pretreatment accomplishes partial brain radioprotective role by reducing iron and oxidative / nitrosative stress in rats
VL  - 59
IS  - 2
SP  - 26
EP  - 32
DO  - 10.5937/hraish1801026s
ER  - 

@article{
author = "Stanojević, Boban and Đukić, Mirjana and Stevanović, Ivana and Ninković, Milica and Đurić, Ana and Gobeljić, Borko and Apostolović, Milan and Pantelić, Ana and Zebić, Goran and Todorović, Lidija and Bojić, Tijana and Savovski, Kiril",
year = "2018",
abstract = "The aim of our study was to test the effect of subacutely applied micronized zeolite [micronized clinoptilolite (MZC)] on brain status of iron (Fe), reactive oxygen and nitrogen species (ROS, RNS), and radioprotective role against brain oxidative/nitrosative stress (OS/NS) initiated by single ionizing radiation of 2 or 10Gray (Gy). Wistar rats on normal (n=18) and 5% MZC supplemented diet (n=18), during 4 weeks, were internally subdivided into 3 subgroups (6 rats in each subgroup), with one of subgroup remaining as a control, and the other two subjected to single ionizing radiation of 2Gy or 10Gy. Thus, we had groups on normal diet: C – controls, 2Gy and 10Gy; and on 5% MZC supplemented diet: MZC, MZC+2Gy and MZC+10Gy. Concentrations of nitrates (a final RNS metabolite) and superoxide anion radical (O2 •-) (an initial ROS) were measured in homogenates of selective vulnerable brain regions (cerebellum, hippocampus and forebrain cortex), while Fe was determined in whole brain of rats. Results documented a significant drop of Fe in MZC and MZC+2Gy/10Gy groups; decrease of O2 •- and nitrate in MZC group; almost equal drop of O2 •- , in 2Gy and MZC+2Gy groups; and nitrate increase in 10Gy and MZC+10Gy groups. We confirmed that subacute MZC pretreatment contributes to partially accomplished brain radioprotective effect in rats exposed to single radiation dose of 2Gy and 10Gy, probably due to reduced OS/NS and Fe.",
journal = "Hrana i ishrana",
title = "Zeolite pretreatment accomplishes partial brain radioprotective role by reducing iron and oxidative / nitrosative stress in rats",
volume = "59",
number = "2",
pages = "26-32",
doi = "10.5937/hraish1801026s"
}

Stanojević, B., Đukić, M., Stevanović, I., Ninković, M., Đurić, A., Gobeljić, B., Apostolović, M., Pantelić, A., Zebić, G., Todorović, L., Bojić, T.,& Savovski, K.. (2018). Zeolite pretreatment accomplishes partial brain radioprotective role by reducing iron and oxidative / nitrosative stress in rats. in Hrana i ishrana, 59(2), 26-32.
https://doi.org/10.5937/hraish1801026s

Stanojević B, Đukić M, Stevanović I, Ninković M, Đurić A, Gobeljić B, Apostolović M, Pantelić A, Zebić G, Todorović L, Bojić T, Savovski K. Zeolite pretreatment accomplishes partial brain radioprotective role by reducing iron and oxidative / nitrosative stress in rats. in Hrana i ishrana. 2018;59(2):26-32.
doi:10.5937/hraish1801026s .

Stanojević, Boban, Đukić, Mirjana, Stevanović, Ivana, Ninković, Milica, Đurić, Ana, Gobeljić, Borko, Apostolović, Milan, Pantelić, Ana, Zebić, Goran, Todorović, Lidija, Bojić, Tijana, Savovski, Kiril, "Zeolite pretreatment accomplishes partial brain radioprotective role by reducing iron and oxidative / nitrosative stress in rats" in Hrana i ishrana, 59, no. 2 (2018):26-32,
https://doi.org/10.5937/hraish1801026s . .

TY  - JOUR
AU  - Kalauzi, Aleksandar
AU  - Vučković, Aleksandra
AU  - Bojić, Tijana
PY  - 2018
UR  - http://link.springer.com/10.1007/s11517-017-1746-3
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7746
AB  - A number of measures, stemming from nonlinear dynamics, exist to estimate complexity of biomedical objects. In most cases they are appropriate, but sometimes unconventional measures, more suited for specific objects, are needed to perform the task. In our present work, we propose three new complexity measures to quantify complexity of topographic closed loops of alpha carrier frequency phase potentials (CFPP) of healthy humans in wake and drowsy states. EEG of ten adult individuals was recorded in both states, using a 14-channel montage. For each subject and each state, a topographic loop (circular directed graph) was constructed according to CFPP values. Circular complexity measure was obtained by summing angles which directed graph edges (arrows) form with the topographic center. Longitudinal complexity was defined as the sum of all arrow lengths, while intersecting complexity was introduced by counting the number of intersections of graph edges. Wilcoxon's signed-ranks test was used on the sets of these three measures, as well as on fractal dimension values of some loop properties, to test differences between loops obtained in wake vs. drowsy. While fractal dimension values were not significantly different, longitudinal and intersecting complexities, as well as anticlockwise circularity, were significantly increased in drowsy.
T2  - Medical & Biological Engineering & Computing
T1  - New complexity measures reveal that topographic loops of human alpha phase potentials are more complex in drowsy than in wake
VL  - 56
IS  - 6
SP  - 967
EP  - 978
DO  - 10.1007/s11517-017-1746-3
ER  - 

@article{
author = "Kalauzi, Aleksandar and Vučković, Aleksandra and Bojić, Tijana",
year = "2018",
abstract = "A number of measures, stemming from nonlinear dynamics, exist to estimate complexity of biomedical objects. In most cases they are appropriate, but sometimes unconventional measures, more suited for specific objects, are needed to perform the task. In our present work, we propose three new complexity measures to quantify complexity of topographic closed loops of alpha carrier frequency phase potentials (CFPP) of healthy humans in wake and drowsy states. EEG of ten adult individuals was recorded in both states, using a 14-channel montage. For each subject and each state, a topographic loop (circular directed graph) was constructed according to CFPP values. Circular complexity measure was obtained by summing angles which directed graph edges (arrows) form with the topographic center. Longitudinal complexity was defined as the sum of all arrow lengths, while intersecting complexity was introduced by counting the number of intersections of graph edges. Wilcoxon's signed-ranks test was used on the sets of these three measures, as well as on fractal dimension values of some loop properties, to test differences between loops obtained in wake vs. drowsy. While fractal dimension values were not significantly different, longitudinal and intersecting complexities, as well as anticlockwise circularity, were significantly increased in drowsy.",
journal = "Medical & Biological Engineering & Computing",
title = "New complexity measures reveal that topographic loops of human alpha phase potentials are more complex in drowsy than in wake",
volume = "56",
number = "6",
pages = "967-978",
doi = "10.1007/s11517-017-1746-3"
}

Kalauzi, A., Vučković, A.,& Bojić, T.. (2018). New complexity measures reveal that topographic loops of human alpha phase potentials are more complex in drowsy than in wake. in Medical & Biological Engineering & Computing, 56(6), 967-978.
https://doi.org/10.1007/s11517-017-1746-3

Kalauzi A, Vučković A, Bojić T. New complexity measures reveal that topographic loops of human alpha phase potentials are more complex in drowsy than in wake. in Medical & Biological Engineering & Computing. 2018;56(6):967-978.
doi:10.1007/s11517-017-1746-3 .

Kalauzi, Aleksandar, Vučković, Aleksandra, Bojić, Tijana, "New complexity measures reveal that topographic loops of human alpha phase potentials are more complex in drowsy than in wake" in Medical & Biological Engineering & Computing, 56, no. 6 (2018):967-978,
https://doi.org/10.1007/s11517-017-1746-3 . .

TY  - JOUR
AU  - Haider, Haula Faruk
AU  - Bojić, Tijana
AU  - Ribeiro, Sara F.
AU  - Paco, Joao
AU  - Hall, Deborah A.
AU  - Szczepek, Agnieszka J.
PY  - 2018
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7985
AB  - Tinnitus is the conscious perception of a sound without a corresponding external acoustic stimulus, usually described as a phantom perception. One of the major challenges for tinnitus research is to understand the pathophysiological mechanisms triggering and maintaining the symptoms, especially for subjective chronic tinnitus. Our objective was to synthesize the published literature in order to provide a comprehensive update on theoretical and experimental advances and to identify further research and clinical directions. We performed literature searches in three electronic databases, complemented by scanning reference lists from relevant reviews in our included records, citation searching of the included articles using Web of Science, and manual searching of the last 6 months of principal otology journals. One-hundred and thirty-two records were included in the review and the information related to peripheral and central mechanisms of tinnitus pathophysiology was collected in order to update on theories and models. A narrative synthesis examined the main themes arising from this information. Tinnitus pathophysiology is complex and multifactorial, involving the auditory and non-auditory systems. Recent theories assume the necessary involvement of extra-auditory brain regions for tinnitus to reach consciousness. Tinnitus engages multiple active dynamic and overlapping networks. We conclude that advancing knowledge concerning the origin and maintenance of specific tinnitus subtypes origin and maintenance mechanisms is of paramount importance for identifying adequate treatment.
T2  - Frontiers in Neuroscience
T1  - Pathophysiology of Subjective Tinnitus: Triggers and Maintenance
VL  - 12
SP  - 00866
DO  - 10.3389/fnins.2018.00866
ER  - 

@article{
author = "Haider, Haula Faruk and Bojić, Tijana and Ribeiro, Sara F. and Paco, Joao and Hall, Deborah A. and Szczepek, Agnieszka J.",
year = "2018",
abstract = "Tinnitus is the conscious perception of a sound without a corresponding external acoustic stimulus, usually described as a phantom perception. One of the major challenges for tinnitus research is to understand the pathophysiological mechanisms triggering and maintaining the symptoms, especially for subjective chronic tinnitus. Our objective was to synthesize the published literature in order to provide a comprehensive update on theoretical and experimental advances and to identify further research and clinical directions. We performed literature searches in three electronic databases, complemented by scanning reference lists from relevant reviews in our included records, citation searching of the included articles using Web of Science, and manual searching of the last 6 months of principal otology journals. One-hundred and thirty-two records were included in the review and the information related to peripheral and central mechanisms of tinnitus pathophysiology was collected in order to update on theories and models. A narrative synthesis examined the main themes arising from this information. Tinnitus pathophysiology is complex and multifactorial, involving the auditory and non-auditory systems. Recent theories assume the necessary involvement of extra-auditory brain regions for tinnitus to reach consciousness. Tinnitus engages multiple active dynamic and overlapping networks. We conclude that advancing knowledge concerning the origin and maintenance of specific tinnitus subtypes origin and maintenance mechanisms is of paramount importance for identifying adequate treatment.",
journal = "Frontiers in Neuroscience",
title = "Pathophysiology of Subjective Tinnitus: Triggers and Maintenance",
volume = "12",
pages = "00866",
doi = "10.3389/fnins.2018.00866"
}

Haider, H. F., Bojić, T., Ribeiro, S. F., Paco, J., Hall, D. A.,& Szczepek, A. J.. (2018). Pathophysiology of Subjective Tinnitus: Triggers and Maintenance. in Frontiers in Neuroscience, 12, 00866.
https://doi.org/10.3389/fnins.2018.00866

Haider HF, Bojić T, Ribeiro SF, Paco J, Hall DA, Szczepek AJ. Pathophysiology of Subjective Tinnitus: Triggers and Maintenance. in Frontiers in Neuroscience. 2018;12:00866.
doi:10.3389/fnins.2018.00866 .

Haider, Haula Faruk, Bojić, Tijana, Ribeiro, Sara F., Paco, Joao, Hall, Deborah A., Szczepek, Agnieszka J., "Pathophysiology of Subjective Tinnitus: Triggers and Maintenance" in Frontiers in Neuroscience, 12 (2018):00866,
https://doi.org/10.3389/fnins.2018.00866 . .

TY  - JOUR
AU  - Bojić, Tijana
AU  - Perović, Vladimir R.
AU  - Senćanski, Milan V.
AU  - Glišić, Sanja
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1823
AB  - Chronic tinnitus is characterized by neuroplastic changes of the auditory cortex. A promising method for therapy of chronic tinnitus is vagus nerve stimulation (VNS) combined with auditory stimulation. The principle of VNS is reversal of pathological neuroplastic changes of the auditory cortex toward physiological neural activity and synchronicity. The VNS mechanism of action in chronic tinnitus patients is prevailingly through the muscarinic neuromodulation of the auditory cortex by the activation of nc. basalis Meynerti. The aim of this study is to propose potential pharmaceutics which may improve the neuromodulatory effects of VNS. The working hypothesis is that M1 receptors have a dominant role in the neural plasticity of the auditory cortex. We propose that allosteric agonists of the muscarinic receptor type 1 (M1) receptor could improve specificity and selectivity of the neuromodulatory effect of VNS on the auditory cortex of chronic tinnitus patients even in the circumstances of lower acetylcholine brain concentration. This intervention would also reinforce the re-learning process of tinnitus (sub) networks by acting on cholinergic memory and learning mechanisms. We performed in silico screening of drug space using the EIIP/AQVN filter and selected 50 drugs as candidates for allosteric modulators of muscarinic receptors. Further filtering of these compounds by means of 3D QSAR and docking revealed 3 approved drugs-bromazepam, estazolam and flumazenil as the most promising candidates for combined chronic tinnitus therapy. These drugs should be further evaluated by biological tests and clinical trials.
T2  - Frontiers in Neuroscience
T1  - Identification of Candidate Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor Which May Improve Vagus Nerve Stimulation in ChronicTinnitus
VL  - 11
SP  - 636
DO  - 10.3389/fnins.2017.00636
ER  - 

@article{
author = "Bojić, Tijana and Perović, Vladimir R. and Senćanski, Milan V. and Glišić, Sanja",
year = "2017",
abstract = "Chronic tinnitus is characterized by neuroplastic changes of the auditory cortex. A promising method for therapy of chronic tinnitus is vagus nerve stimulation (VNS) combined with auditory stimulation. The principle of VNS is reversal of pathological neuroplastic changes of the auditory cortex toward physiological neural activity and synchronicity. The VNS mechanism of action in chronic tinnitus patients is prevailingly through the muscarinic neuromodulation of the auditory cortex by the activation of nc. basalis Meynerti. The aim of this study is to propose potential pharmaceutics which may improve the neuromodulatory effects of VNS. The working hypothesis is that M1 receptors have a dominant role in the neural plasticity of the auditory cortex. We propose that allosteric agonists of the muscarinic receptor type 1 (M1) receptor could improve specificity and selectivity of the neuromodulatory effect of VNS on the auditory cortex of chronic tinnitus patients even in the circumstances of lower acetylcholine brain concentration. This intervention would also reinforce the re-learning process of tinnitus (sub) networks by acting on cholinergic memory and learning mechanisms. We performed in silico screening of drug space using the EIIP/AQVN filter and selected 50 drugs as candidates for allosteric modulators of muscarinic receptors. Further filtering of these compounds by means of 3D QSAR and docking revealed 3 approved drugs-bromazepam, estazolam and flumazenil as the most promising candidates for combined chronic tinnitus therapy. These drugs should be further evaluated by biological tests and clinical trials.",
journal = "Frontiers in Neuroscience",
title = "Identification of Candidate Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor Which May Improve Vagus Nerve Stimulation in ChronicTinnitus",
volume = "11",
pages = "636",
doi = "10.3389/fnins.2017.00636"
}

Bojić, T., Perović, V. R., Senćanski, M. V.,& Glišić, S.. (2017). Identification of Candidate Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor Which May Improve Vagus Nerve Stimulation in ChronicTinnitus. in Frontiers in Neuroscience, 11, 636.
https://doi.org/10.3389/fnins.2017.00636

Bojić T, Perović VR, Senćanski MV, Glišić S. Identification of Candidate Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor Which May Improve Vagus Nerve Stimulation in ChronicTinnitus. in Frontiers in Neuroscience. 2017;11:636.
doi:10.3389/fnins.2017.00636 .

Bojić, Tijana, Perović, Vladimir R., Senćanski, Milan V., Glišić, Sanja, "Identification of Candidate Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor Which May Improve Vagus Nerve Stimulation in ChronicTinnitus" in Frontiers in Neuroscience, 11 (2017):636,
https://doi.org/10.3389/fnins.2017.00636 . .

TY  - JOUR
AU  - Glišić, Sanja
AU  - Cavanaugh, David P.
AU  - Chittur, Krishnan K.
AU  - Senćanski, Milan V.
AU  - Perović, Vladimir R.
AU  - Bojić, Tijana
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/977
AB  - Background: The pathophysiological overlapping between Sjorgens Syndrome (SS) and HCV, presence of anti-muscarinic receptor type 3 (M3R) antibodies in SS, the role that M3R plays in the regulation of the heart rate, has led to the assumption that cardiovagal dysfunction in HCV patients is caused by anti-M3R antibodies elicited by HCV proteins or by their direct interaction with M3R. Results: To identify HCV protein which possibly is crossreactive with M3R or which binds to this receptor, we performed the Informational Spectrum Method (ISM) analysis of the HCV proteome. This analysis revealed that NS5A protein represents the most probable interactor of M3R or that this viral protein could elicit antibodies which modulate function of this receptor. Further detailed structure/function analysis of NS5A and M3R performed by the ISM method extended with other Digital Signal processing (DSP) approaches revealed domains of these proteins which participate in their crossreactivity or in their direct interaction, representing promising diagnostic and therapeutic targets. Conclusions: Application of the ISM with other compatible bioinformatics methods offers new perspectives for identifying diagnostic and therapeutic targets for complicated forms of HCV and other viral infections. We show how the electron-ion interaction potential (EIIP) amino-acid scale used in the ISM combined with a robust, high performance hydrophobicity scale can provide new insights for understanding protein structure/function and protein-protein interactions.
T2  - BMC Bioinformatics
T1  - Common molecular mechanism of the hepatic lesion and the cardiac parasympathetic regulation in chronic hepatitis C infection: a critical role for the muscarinic receptor type 3
VL  - 17
SP  - 139
DO  - 10.1186/s12859-016-0988-7
ER  - 

@article{
author = "Glišić, Sanja and Cavanaugh, David P. and Chittur, Krishnan K. and Senćanski, Milan V. and Perović, Vladimir R. and Bojić, Tijana",
year = "2016",
abstract = "Background: The pathophysiological overlapping between Sjorgens Syndrome (SS) and HCV, presence of anti-muscarinic receptor type 3 (M3R) antibodies in SS, the role that M3R plays in the regulation of the heart rate, has led to the assumption that cardiovagal dysfunction in HCV patients is caused by anti-M3R antibodies elicited by HCV proteins or by their direct interaction with M3R. Results: To identify HCV protein which possibly is crossreactive with M3R or which binds to this receptor, we performed the Informational Spectrum Method (ISM) analysis of the HCV proteome. This analysis revealed that NS5A protein represents the most probable interactor of M3R or that this viral protein could elicit antibodies which modulate function of this receptor. Further detailed structure/function analysis of NS5A and M3R performed by the ISM method extended with other Digital Signal processing (DSP) approaches revealed domains of these proteins which participate in their crossreactivity or in their direct interaction, representing promising diagnostic and therapeutic targets. Conclusions: Application of the ISM with other compatible bioinformatics methods offers new perspectives for identifying diagnostic and therapeutic targets for complicated forms of HCV and other viral infections. We show how the electron-ion interaction potential (EIIP) amino-acid scale used in the ISM combined with a robust, high performance hydrophobicity scale can provide new insights for understanding protein structure/function and protein-protein interactions.",
journal = "BMC Bioinformatics",
title = "Common molecular mechanism of the hepatic lesion and the cardiac parasympathetic regulation in chronic hepatitis C infection: a critical role for the muscarinic receptor type 3",
volume = "17",
pages = "139",
doi = "10.1186/s12859-016-0988-7"
}

Glišić, S., Cavanaugh, D. P., Chittur, K. K., Senćanski, M. V., Perović, V. R.,& Bojić, T.. (2016). Common molecular mechanism of the hepatic lesion and the cardiac parasympathetic regulation in chronic hepatitis C infection: a critical role for the muscarinic receptor type 3. in BMC Bioinformatics, 17, 139.
https://doi.org/10.1186/s12859-016-0988-7

Glišić S, Cavanaugh DP, Chittur KK, Senćanski MV, Perović VR, Bojić T. Common molecular mechanism of the hepatic lesion and the cardiac parasympathetic regulation in chronic hepatitis C infection: a critical role for the muscarinic receptor type 3. in BMC Bioinformatics. 2016;17:139.
doi:10.1186/s12859-016-0988-7 .

Glišić, Sanja, Cavanaugh, David P., Chittur, Krishnan K., Senćanski, Milan V., Perović, Vladimir R., Bojić, Tijana, "Common molecular mechanism of the hepatic lesion and the cardiac parasympathetic regulation in chronic hepatitis C infection: a critical role for the muscarinic receptor type 3" in BMC Bioinformatics, 17 (2016):139,
https://doi.org/10.1186/s12859-016-0988-7 . .

TY  - JOUR
AU  - Bojić, Tijana
AU  - Perović, Vladimir R.
AU  - Glišić, Sanja
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/900
AB  - Neurocardiovascular diseases (NCVD) are the leading cause of death in the developed world and will remain so till 2020. In these diseases the pathologically changed nervous control of cardiovascular system has the central role. The actual NCV syndromes are neurogenic hypertension, representing the sympathetically mediated disorder, and vasovagal syncope, which is the vagally mediated disorders. Vasovagal syncope, the disease far from its etiological treatment, could benefit from recruiting and application of antimuscarinic drugs used in other parasympathetic disorders. The informational spectrum method (ISM), a method widely applied for the characterization of protein-protein interactions in the field of immunology, endocrinology and anti HIV drug discovery, was applied for the first time in the analysis of neurogenic hypertension and vasovagal syncope therapeutic targets. In silico analysis revealed the potential involvement of apelin in neurogenic hypertension. Applying the EIIP/ISM bioinformatics concept in investigation of drugs for treatment of vasovagal syncope suggests that 78% of tested antimuscarinic drugs could have anti vasovagal syncope effect. The presented results confirm that ISM is a promissing method for investigation of molecular mechanisms underlying pathophysiological proceses of NCV syndromes and discovery of therapeutics targets for their treatment.
T2  - Frontiers in Neuroscience
T1  - In silico Therapeutics for Neurogenic Hypertension and Vasovagal Syncope
VL  - 9
SP  - 520
DO  - 10.3389/fnins.2015.00520
ER  - 

@article{
author = "Bojić, Tijana and Perović, Vladimir R. and Glišić, Sanja",
year = "2016",
abstract = "Neurocardiovascular diseases (NCVD) are the leading cause of death in the developed world and will remain so till 2020. In these diseases the pathologically changed nervous control of cardiovascular system has the central role. The actual NCV syndromes are neurogenic hypertension, representing the sympathetically mediated disorder, and vasovagal syncope, which is the vagally mediated disorders. Vasovagal syncope, the disease far from its etiological treatment, could benefit from recruiting and application of antimuscarinic drugs used in other parasympathetic disorders. The informational spectrum method (ISM), a method widely applied for the characterization of protein-protein interactions in the field of immunology, endocrinology and anti HIV drug discovery, was applied for the first time in the analysis of neurogenic hypertension and vasovagal syncope therapeutic targets. In silico analysis revealed the potential involvement of apelin in neurogenic hypertension. Applying the EIIP/ISM bioinformatics concept in investigation of drugs for treatment of vasovagal syncope suggests that 78% of tested antimuscarinic drugs could have anti vasovagal syncope effect. The presented results confirm that ISM is a promissing method for investigation of molecular mechanisms underlying pathophysiological proceses of NCV syndromes and discovery of therapeutics targets for their treatment.",
journal = "Frontiers in Neuroscience",
title = "In silico Therapeutics for Neurogenic Hypertension and Vasovagal Syncope",
volume = "9",
pages = "520",
doi = "10.3389/fnins.2015.00520"
}

Bojić, T., Perović, V. R.,& Glišić, S.. (2016). In silico Therapeutics for Neurogenic Hypertension and Vasovagal Syncope. in Frontiers in Neuroscience, 9, 520.
https://doi.org/10.3389/fnins.2015.00520

Bojić T, Perović VR, Glišić S. In silico Therapeutics for Neurogenic Hypertension and Vasovagal Syncope. in Frontiers in Neuroscience. 2016;9:520.
doi:10.3389/fnins.2015.00520 .

Bojić, Tijana, Perović, Vladimir R., Glišić, Sanja, "In silico Therapeutics for Neurogenic Hypertension and Vasovagal Syncope" in Frontiers in Neuroscience, 9 (2016):520,
https://doi.org/10.3389/fnins.2015.00520 . .

TY  - JOUR
AU  - Platiša, Mirjana M.
AU  - Bojić, Tijana
AU  - Pavlović, Siniša U.
AU  - Radovanovic, Nikola N.
AU  - Kalauzi, Aleksandar
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/941
AB  - Classical Poincare plot is a standard way to measure nonlinear regulation of cardiovascular control. In our work we propose a generalized form of Poincare plot where we track correlation between the duration of j preceding and k next RR intervals. The investigation was done in healthy subjects and patients with atrial fibrillation, by varying j,k LT = 100. In cases where j = k, in healthy subjects the typical pattern was observed by paths that were substituting scatterplots and that were initiated and ended by loops of Poincare plot points. This was not the case for atrial fibrillation patients where Poincare plot had a simple scattered form. More, a typical matrix of Pearsons correlation coefficients, r(j,k), showed different positions of local maxima, depending on the subjects health condition. In both groups, local maxima were grouped into four clusters which probably determined specific regulatory mechanisms according to correlations between the duration of symmetric and asymmetric observed RR intervals. We quantified matrices degrees of asymmetry and found that they were significantly different: distributed around zero in healthy, while being negative in atrial fibrillation. Also, Pearsons coefficients were higher in healthy than in atrial fibrillation or in signals with reshuffled intervals. Our hypothesis is that by this novel method we can observe heart rate regimes typical for baseline conditions and defense reaction in healthy subjects. These data indicate that neural control mechanisms of heart rate are operating in healthy subjects in contrast with atrial fibrillation, identifying it as the state of risk for stress-dependent pathologies. Regulatory regimes of heart rate can be further quantified and explored by the proposed novel method.
T2  - Frontiers in Neuroscience
T1  - Generalized Poincare Plots-A New Method for Evaluation of Regimes in Cardiac Neural Control in Atrial Fibrillation and Healthy Subjects
VL  - 10
SP  - 38
DO  - 10.3389/fnins.2016.00038
ER  - 

@article{
author = "Platiša, Mirjana M. and Bojić, Tijana and Pavlović, Siniša U. and Radovanovic, Nikola N. and Kalauzi, Aleksandar",
year = "2016",
abstract = "Classical Poincare plot is a standard way to measure nonlinear regulation of cardiovascular control. In our work we propose a generalized form of Poincare plot where we track correlation between the duration of j preceding and k next RR intervals. The investigation was done in healthy subjects and patients with atrial fibrillation, by varying j,k LT = 100. In cases where j = k, in healthy subjects the typical pattern was observed by paths that were substituting scatterplots and that were initiated and ended by loops of Poincare plot points. This was not the case for atrial fibrillation patients where Poincare plot had a simple scattered form. More, a typical matrix of Pearsons correlation coefficients, r(j,k), showed different positions of local maxima, depending on the subjects health condition. In both groups, local maxima were grouped into four clusters which probably determined specific regulatory mechanisms according to correlations between the duration of symmetric and asymmetric observed RR intervals. We quantified matrices degrees of asymmetry and found that they were significantly different: distributed around zero in healthy, while being negative in atrial fibrillation. Also, Pearsons coefficients were higher in healthy than in atrial fibrillation or in signals with reshuffled intervals. Our hypothesis is that by this novel method we can observe heart rate regimes typical for baseline conditions and defense reaction in healthy subjects. These data indicate that neural control mechanisms of heart rate are operating in healthy subjects in contrast with atrial fibrillation, identifying it as the state of risk for stress-dependent pathologies. Regulatory regimes of heart rate can be further quantified and explored by the proposed novel method.",
journal = "Frontiers in Neuroscience",
title = "Generalized Poincare Plots-A New Method for Evaluation of Regimes in Cardiac Neural Control in Atrial Fibrillation and Healthy Subjects",
volume = "10",
pages = "38",
doi = "10.3389/fnins.2016.00038"
}

Platiša, M. M., Bojić, T., Pavlović, S. U., Radovanovic, N. N.,& Kalauzi, A.. (2016). Generalized Poincare Plots-A New Method for Evaluation of Regimes in Cardiac Neural Control in Atrial Fibrillation and Healthy Subjects. in Frontiers in Neuroscience, 10, 38.
https://doi.org/10.3389/fnins.2016.00038

Platiša MM, Bojić T, Pavlović SU, Radovanovic NN, Kalauzi A. Generalized Poincare Plots-A New Method for Evaluation of Regimes in Cardiac Neural Control in Atrial Fibrillation and Healthy Subjects. in Frontiers in Neuroscience. 2016;10:38.
doi:10.3389/fnins.2016.00038 .

Platiša, Mirjana M., Bojić, Tijana, Pavlović, Siniša U., Radovanovic, Nikola N., Kalauzi, Aleksandar, "Generalized Poincare Plots-A New Method for Evaluation of Regimes in Cardiac Neural Control in Atrial Fibrillation and Healthy Subjects" in Frontiers in Neuroscience, 10 (2016):38,
https://doi.org/10.3389/fnins.2016.00038 . .

TY  - JOUR
AU  - Platiša, Mirjana M.
AU  - Bojić, Tijana
AU  - Pavlović, Siniša U.
AU  - Radovanovic, Nikola N.
AU  - Kalauzi, Aleksandar
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1332
AB  - Rearranged origin of heart rhythm in patients with atrial fibrillation (AF) influences the regulation of the heart and consequently the respiratory rhythm, and the bidirectional interaction of these rhythms not documented. Hence, we examined coupling of the RR interval and the respiration (Resp) signal by coherence, Granger causality and the cross-sample entropy method of time series analysis in patients with AF and a healthy control group. In healthy subjects, the influence of respiration on cardiac rhythm was found as increased coherence at the breathing frequency (BF) range, significantly stronger interaction and synchrony from Resp to RR than from RR to Resp. On the contrary, in patients with AF, coherence at BF diminished, there were no causal interactions between signals in both directions, which resulted in equally great asynchrony between them. In AF, the absence of full functionality of the sinoatrial node, as an integrator of neural cardiac control, resulted in diminished vagal modulation of heart periods and consequently impaired bidirectional cardio-respiratory interaction.
T2  - Biomedical Engineering / Biomedizinische Technik
T1  - Uncoupling of cardiac and respiratory rhythm in atrial fibrillation
VL  - 61
IS  - 6
SP  - 657
EP  - 663
DO  - 10.1515/bmt-2016-0057
ER  - 

@article{
author = "Platiša, Mirjana M. and Bojić, Tijana and Pavlović, Siniša U. and Radovanovic, Nikola N. and Kalauzi, Aleksandar",
year = "2016",
abstract = "Rearranged origin of heart rhythm in patients with atrial fibrillation (AF) influences the regulation of the heart and consequently the respiratory rhythm, and the bidirectional interaction of these rhythms not documented. Hence, we examined coupling of the RR interval and the respiration (Resp) signal by coherence, Granger causality and the cross-sample entropy method of time series analysis in patients with AF and a healthy control group. In healthy subjects, the influence of respiration on cardiac rhythm was found as increased coherence at the breathing frequency (BF) range, significantly stronger interaction and synchrony from Resp to RR than from RR to Resp. On the contrary, in patients with AF, coherence at BF diminished, there were no causal interactions between signals in both directions, which resulted in equally great asynchrony between them. In AF, the absence of full functionality of the sinoatrial node, as an integrator of neural cardiac control, resulted in diminished vagal modulation of heart periods and consequently impaired bidirectional cardio-respiratory interaction.",
journal = "Biomedical Engineering / Biomedizinische Technik",
title = "Uncoupling of cardiac and respiratory rhythm in atrial fibrillation",
volume = "61",
number = "6",
pages = "657-663",
doi = "10.1515/bmt-2016-0057"
}

Platiša, M. M., Bojić, T., Pavlović, S. U., Radovanovic, N. N.,& Kalauzi, A.. (2016). Uncoupling of cardiac and respiratory rhythm in atrial fibrillation. in Biomedical Engineering / Biomedizinische Technik, 61(6), 657-663.
https://doi.org/10.1515/bmt-2016-0057

Platiša MM, Bojić T, Pavlović SU, Radovanovic NN, Kalauzi A. Uncoupling of cardiac and respiratory rhythm in atrial fibrillation. in Biomedical Engineering / Biomedizinische Technik. 2016;61(6):657-663.
doi:10.1515/bmt-2016-0057 .

Platiša, Mirjana M., Bojić, Tijana, Pavlović, Siniša U., Radovanovic, Nikola N., Kalauzi, Aleksandar, "Uncoupling of cardiac and respiratory rhythm in atrial fibrillation" in Biomedical Engineering / Biomedizinische Technik, 61, no. 6 (2016):657-663,
https://doi.org/10.1515/bmt-2016-0057 . .

TY  - CONF
AU  - Životić, Ivan
AU  - Đurić-Delić, Tamara
AU  - Živković, Maja
AU  - Bojić, Tijana
AU  - Milovanović, Branislav
AU  - Alavantić, Dragan
AU  - Stanković, Aleksandra
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11401
PB  - Belgrade : Serbian Neurocardiological Society
C3  - NEUROCARD 2015 : 7th Congress of Serbian neuroscience society with international participation, 6th International Symposium on Noninvasive Electrocardiology :  Program and the book of abstracts
T1  - The eNOS rs1799983 gene polymorphism (Glu298Asp) in association with cardiovascular profiles in patients with vasovagal syncope
SP  - 33
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11401
ER  - 

@conference{
author = "Životić, Ivan and Đurić-Delić, Tamara and Živković, Maja and Bojić, Tijana and Milovanović, Branislav and Alavantić, Dragan and Stanković, Aleksandra",
year = "2015",
publisher = "Belgrade : Serbian Neurocardiological Society",
journal = "NEUROCARD 2015 : 7th Congress of Serbian neuroscience society with international participation, 6th International Symposium on Noninvasive Electrocardiology :  Program and the book of abstracts",
title = "The eNOS rs1799983 gene polymorphism (Glu298Asp) in association with cardiovascular profiles in patients with vasovagal syncope",
pages = "33",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11401"
}

Životić, I., Đurić-Delić, T., Živković, M., Bojić, T., Milovanović, B., Alavantić, D.,& Stanković, A.. (2015). The eNOS rs1799983 gene polymorphism (Glu298Asp) in association with cardiovascular profiles in patients with vasovagal syncope. in NEUROCARD 2015 : 7th Congress of Serbian neuroscience society with international participation, 6th International Symposium on Noninvasive Electrocardiology :  Program and the book of abstracts
Belgrade : Serbian Neurocardiological Society., 33.
https://hdl.handle.net/21.15107/rcub_vinar_11401

Životić I, Đurić-Delić T, Živković M, Bojić T, Milovanović B, Alavantić D, Stanković A. The eNOS rs1799983 gene polymorphism (Glu298Asp) in association with cardiovascular profiles in patients with vasovagal syncope. in NEUROCARD 2015 : 7th Congress of Serbian neuroscience society with international participation, 6th International Symposium on Noninvasive Electrocardiology :  Program and the book of abstracts. 2015;:33.
https://hdl.handle.net/21.15107/rcub_vinar_11401 .

Životić, Ivan, Đurić-Delić, Tamara, Živković, Maja, Bojić, Tijana, Milovanović, Branislav, Alavantić, Dragan, Stanković, Aleksandra, "The eNOS rs1799983 gene polymorphism (Glu298Asp) in association with cardiovascular profiles in patients with vasovagal syncope" in NEUROCARD 2015 : 7th Congress of Serbian neuroscience society with international participation, 6th International Symposium on Noninvasive Electrocardiology :  Program and the book of abstracts (2015):33,
https://hdl.handle.net/21.15107/rcub_vinar_11401 .

TY  - CONF
AU  - Živković, Maja
AU  - Životić, Ivan
AU  - Bošković, Maja
AU  - Milovanović, Branislav
AU  - Bojić, Tijana
AU  - Alavantić, Dragan
AU  - Stanković, Aleksandra
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11402
PB  - Belgrade : Serbian Neurocardiological Society
C3  - NEUROCARD 2015 : 7th Congress of Serbian neuroscience society with international participation, 6th International Symposium on Noninvasive Electrocardiology :  Program and the book of abstracts
T1  - Effects of glutathione S-transferase T1 and M1 deletions on electrocardiographic and heart rate variability parameters in patients with vasovagal syncope
SP  - 34
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11402
ER  - 

@conference{
author = "Živković, Maja and Životić, Ivan and Bošković, Maja and Milovanović, Branislav and Bojić, Tijana and Alavantić, Dragan and Stanković, Aleksandra",
year = "2015",
publisher = "Belgrade : Serbian Neurocardiological Society",
journal = "NEUROCARD 2015 : 7th Congress of Serbian neuroscience society with international participation, 6th International Symposium on Noninvasive Electrocardiology :  Program and the book of abstracts",
title = "Effects of glutathione S-transferase T1 and M1 deletions on electrocardiographic and heart rate variability parameters in patients with vasovagal syncope",
pages = "34",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11402"
}

Živković, M., Životić, I., Bošković, M., Milovanović, B., Bojić, T., Alavantić, D.,& Stanković, A.. (2015). Effects of glutathione S-transferase T1 and M1 deletions on electrocardiographic and heart rate variability parameters in patients with vasovagal syncope. in NEUROCARD 2015 : 7th Congress of Serbian neuroscience society with international participation, 6th International Symposium on Noninvasive Electrocardiology :  Program and the book of abstracts
Belgrade : Serbian Neurocardiological Society., 34.
https://hdl.handle.net/21.15107/rcub_vinar_11402

Živković M, Životić I, Bošković M, Milovanović B, Bojić T, Alavantić D, Stanković A. Effects of glutathione S-transferase T1 and M1 deletions on electrocardiographic and heart rate variability parameters in patients with vasovagal syncope. in NEUROCARD 2015 : 7th Congress of Serbian neuroscience society with international participation, 6th International Symposium on Noninvasive Electrocardiology :  Program and the book of abstracts. 2015;:34.
https://hdl.handle.net/21.15107/rcub_vinar_11402 .

Živković, Maja, Životić, Ivan, Bošković, Maja, Milovanović, Branislav, Bojić, Tijana, Alavantić, Dragan, Stanković, Aleksandra, "Effects of glutathione S-transferase T1 and M1 deletions on electrocardiographic and heart rate variability parameters in patients with vasovagal syncope" in NEUROCARD 2015 : 7th Congress of Serbian neuroscience society with international participation, 6th International Symposium on Noninvasive Electrocardiology :  Program and the book of abstracts (2015):34,
https://hdl.handle.net/21.15107/rcub_vinar_11402 .

TY  - JOUR
AU  - Bojić, Tijana
AU  - Milovanović, Branislav
AU  - Jovanović-Ćupić, Snežana P.
PY  - 2015
UR  - http://www.archivesofmedicine.com/abstract/genetic-polymorphisms-of-neurocardiovascular-disorders-6481.html
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8409
AB  - The autonomic nervous control of cardiovascular (CV) system plays a major role in the adaptation of the organism to the changes in external and internal environment. It’s dysfunction is the major pathophysiological factor in the development of neurocardiovascular diseases. The aim of this review is to present the state of the art on the role of candidate gene polymorphisms of the molecules in the signaling chain of neurocardiovascular transmission in neurocardiovascular diseases. Neurocardiovascular disorders can be classified as sympathetic vs. vagally mediated disorders, though in many disorders both systems are dysfunctional. A number of molecules along the signaling pathway can be functionally modified and be the background of the predisposition, faster progression or complicated form of the disease. When the disease is the consequence of the joined parasympathetic and sympathetic nervous system disequilibrium, the focus of neurogenetic research should be on molecules providing the cross-talk between the two systems: on intercellular and intracellular level and on the level of the signaling process integration. An aggregation of positive results for the association between certain genes and different neurocardiovascular phenotypes pointed on a specific "neurocardiovascular genetic hotspots". Identification of these genes could be of particular interest as a diagnostic tool in the clustered form of neurocardiovascular diseases. New data obtained from neurogenetic approach will improve the disease outcome by gene, pharmacologic and behavioral modulation of the autonomic nervous system.
T2  - Archives of Medicine
T1  - Genetic Polymorphisms of Neurocardiovascular Disorders
VL  - 7
IS  - 2
UR  - https://hdl.handle.net/21.15107/rcub_vinar_8409
ER  - 

@article{
author = "Bojić, Tijana and Milovanović, Branislav and Jovanović-Ćupić, Snežana P.",
year = "2015",
abstract = "The autonomic nervous control of cardiovascular (CV) system plays a major role in the adaptation of the organism to the changes in external and internal environment. It’s dysfunction is the major pathophysiological factor in the development of neurocardiovascular diseases. The aim of this review is to present the state of the art on the role of candidate gene polymorphisms of the molecules in the signaling chain of neurocardiovascular transmission in neurocardiovascular diseases. Neurocardiovascular disorders can be classified as sympathetic vs. vagally mediated disorders, though in many disorders both systems are dysfunctional. A number of molecules along the signaling pathway can be functionally modified and be the background of the predisposition, faster progression or complicated form of the disease. When the disease is the consequence of the joined parasympathetic and sympathetic nervous system disequilibrium, the focus of neurogenetic research should be on molecules providing the cross-talk between the two systems: on intercellular and intracellular level and on the level of the signaling process integration. An aggregation of positive results for the association between certain genes and different neurocardiovascular phenotypes pointed on a specific "neurocardiovascular genetic hotspots". Identification of these genes could be of particular interest as a diagnostic tool in the clustered form of neurocardiovascular diseases. New data obtained from neurogenetic approach will improve the disease outcome by gene, pharmacologic and behavioral modulation of the autonomic nervous system.",
journal = "Archives of Medicine",
title = "Genetic Polymorphisms of Neurocardiovascular Disorders",
volume = "7",
number = "2",
url = "https://hdl.handle.net/21.15107/rcub_vinar_8409"
}

Bojić, T., Milovanović, B.,& Jovanović-Ćupić, S. P.. (2015). Genetic Polymorphisms of Neurocardiovascular Disorders. in Archives of Medicine, 7(2).
https://hdl.handle.net/21.15107/rcub_vinar_8409

Bojić T, Milovanović B, Jovanović-Ćupić SP. Genetic Polymorphisms of Neurocardiovascular Disorders. in Archives of Medicine. 2015;7(2).
https://hdl.handle.net/21.15107/rcub_vinar_8409 .

Bojić, Tijana, Milovanović, Branislav, Jovanović-Ćupić, Snežana P., "Genetic Polymorphisms of Neurocardiovascular Disorders" in Archives of Medicine, 7, no. 2 (2015),
https://hdl.handle.net/21.15107/rcub_vinar_8409 .

TY  - JOUR
AU  - Kalauzi, Aleksandar
AU  - Vučković, Aleksandra
AU  - Bojić, Tijana
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/475
AB  - Organization of resting state cortical networks is of fundamental importance for the phenomenon of awareness, which is altered in the first part of hypnagogic period (Hori stages 1-4). Our aim was to investigate the change in brain topography pattern of EEG alpha attractor correlation dimension (CD) in the period of transition from Hori stage 1 to 4. EEG of ten healthy adult individuals was recorded in the wake and drowsy states, using a 14 channel average reference montage, from which 91 bipolar channels were derived and filtered in the wider alpha (6-14 Hz) range. Sixty 1 s long epochs of each state and individual were subjected to CD calculation according to the Grassberger-Procaccia method. For such a collection of signals, two embedding dimensions, d = {5,10}, and 22 time delays 7 = 2-23 samples were explored. Optimal values were d = 10 and 7 = 18, where both saturation and second zero crossing of the autocorrelation function occurred. Bipolar channel CD underwent a significant decrease during the transition and showed a positive linear correlation with electrode distance, stronger in the wake individuals. Topographic distribution of bipolar channels with above median CD changed from longitudinal anterior-posterior pattern (awake) to a more diagonal pattern, with localization in posterior regions (drowsiness). Our data are in line with the literature reporting functional segregation of neuronal assemblies in anterior and posterior regions during this transition. Our results should contribute to understanding of complex reorganization of the cortical part of alpha generators during the wake/drowsy transition. (C) 2014 Elsevier B.V. All rights reserved.
T2  - International Journal of Psychophysiology
T1  - Topographic distribution of EEG alpha attractor correlation dimension values in wake and drowsy states in humans
VL  - 95
IS  - 3
SP  - 278
EP  - 291
DO  - 10.1016/j.ijpsycho.2014.11.008
ER  - 

@article{
author = "Kalauzi, Aleksandar and Vučković, Aleksandra and Bojić, Tijana",
year = "2015",
abstract = "Organization of resting state cortical networks is of fundamental importance for the phenomenon of awareness, which is altered in the first part of hypnagogic period (Hori stages 1-4). Our aim was to investigate the change in brain topography pattern of EEG alpha attractor correlation dimension (CD) in the period of transition from Hori stage 1 to 4. EEG of ten healthy adult individuals was recorded in the wake and drowsy states, using a 14 channel average reference montage, from which 91 bipolar channels were derived and filtered in the wider alpha (6-14 Hz) range. Sixty 1 s long epochs of each state and individual were subjected to CD calculation according to the Grassberger-Procaccia method. For such a collection of signals, two embedding dimensions, d = {5,10}, and 22 time delays 7 = 2-23 samples were explored. Optimal values were d = 10 and 7 = 18, where both saturation and second zero crossing of the autocorrelation function occurred. Bipolar channel CD underwent a significant decrease during the transition and showed a positive linear correlation with electrode distance, stronger in the wake individuals. Topographic distribution of bipolar channels with above median CD changed from longitudinal anterior-posterior pattern (awake) to a more diagonal pattern, with localization in posterior regions (drowsiness). Our data are in line with the literature reporting functional segregation of neuronal assemblies in anterior and posterior regions during this transition. Our results should contribute to understanding of complex reorganization of the cortical part of alpha generators during the wake/drowsy transition. (C) 2014 Elsevier B.V. All rights reserved.",
journal = "International Journal of Psychophysiology",
title = "Topographic distribution of EEG alpha attractor correlation dimension values in wake and drowsy states in humans",
volume = "95",
number = "3",
pages = "278-291",
doi = "10.1016/j.ijpsycho.2014.11.008"
}

Kalauzi, A., Vučković, A.,& Bojić, T.. (2015). Topographic distribution of EEG alpha attractor correlation dimension values in wake and drowsy states in humans. in International Journal of Psychophysiology, 95(3), 278-291.
https://doi.org/10.1016/j.ijpsycho.2014.11.008

Kalauzi A, Vučković A, Bojić T. Topographic distribution of EEG alpha attractor correlation dimension values in wake and drowsy states in humans. in International Journal of Psychophysiology. 2015;95(3):278-291.
doi:10.1016/j.ijpsycho.2014.11.008 .

Kalauzi, Aleksandar, Vučković, Aleksandra, Bojić, Tijana, "Topographic distribution of EEG alpha attractor correlation dimension values in wake and drowsy states in humans" in International Journal of Psychophysiology, 95, no. 3 (2015):278-291,
https://doi.org/10.1016/j.ijpsycho.2014.11.008 . .

TY  - CONF
AU  - Kolić, Ivana
AU  - Jovanović, Ivan
AU  - Bojić Milinović, Tijana
AU  - Milovanović, Branislav
AU  - Đurić, Tamara
AU  - Alavantić, Dragan
AU  - Stanković, Aleksandra
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12687
PB  - Belgrade : Serbian Neuroscience Society
C3  - NEUROCARD 2014 : 6th International Symposium on Neurocardiology : The 5th International Symposium on Noninvasive Electrocardiology : Book of abstracts
T1  - Renin-angiotensin system gene polymorphisms in association with cardiovascular profiles in patients with vasovagal syncope
SP  - 58
EP  - 58
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12687
ER  - 

@conference{
author = "Kolić, Ivana and Jovanović, Ivan and Bojić Milinović, Tijana and Milovanović, Branislav and Đurić, Tamara and Alavantić, Dragan and Stanković, Aleksandra",
year = "2014",
publisher = "Belgrade : Serbian Neuroscience Society",
journal = "NEUROCARD 2014 : 6th International Symposium on Neurocardiology : The 5th International Symposium on Noninvasive Electrocardiology : Book of abstracts",
title = "Renin-angiotensin system gene polymorphisms in association with cardiovascular profiles in patients with vasovagal syncope",
pages = "58-58",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12687"
}

Kolić, I., Jovanović, I., Bojić Milinović, T., Milovanović, B., Đurić, T., Alavantić, D.,& Stanković, A.. (2014). Renin-angiotensin system gene polymorphisms in association with cardiovascular profiles in patients with vasovagal syncope. in NEUROCARD 2014 : 6th International Symposium on Neurocardiology : The 5th International Symposium on Noninvasive Electrocardiology : Book of abstracts
Belgrade : Serbian Neuroscience Society., 58-58.
https://hdl.handle.net/21.15107/rcub_vinar_12687

Kolić I, Jovanović I, Bojić Milinović T, Milovanović B, Đurić T, Alavantić D, Stanković A. Renin-angiotensin system gene polymorphisms in association with cardiovascular profiles in patients with vasovagal syncope. in NEUROCARD 2014 : 6th International Symposium on Neurocardiology : The 5th International Symposium on Noninvasive Electrocardiology : Book of abstracts. 2014;:58-58.
https://hdl.handle.net/21.15107/rcub_vinar_12687 .

Kolić, Ivana, Jovanović, Ivan, Bojić Milinović, Tijana, Milovanović, Branislav, Đurić, Tamara, Alavantić, Dragan, Stanković, Aleksandra, "Renin-angiotensin system gene polymorphisms in association with cardiovascular profiles in patients with vasovagal syncope" in NEUROCARD 2014 : 6th International Symposium on Neurocardiology : The 5th International Symposium on Noninvasive Electrocardiology : Book of abstracts (2014):58-58,
https://hdl.handle.net/21.15107/rcub_vinar_12687 .

TY  - JOUR
AU  - Jovanović-Ćupić, Snežana P.
AU  - Glišić, Sanja
AU  - Stanojevic, M.
AU  - Vasiljević, N.
AU  - Bojić, Tijana
AU  - Božović, Ana M.
AU  - Dimitrijević, Bogomir B.
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5858
AB  - Hepatitis C virus infection is the most common chronic blood-borne infection and one of the most important causes of chronic liver disease. Knowing the predictors associated with pegylated interferon/ribavirin (PEG-IFN/RBV) combination therapy response is important for evidence-based treatment recommendations. The goal of this study was to identify host and viral factors of response to PEG-IFN/RBV treatment in chronic hepatitis C genotype 1b patients. We have examined the relationship between gender, age, level of alanine aminotransferase (ALT), viral load and liver fibrosis progression on therapy response. ALT level and viral load were evaluated before starting treatment with combination therapy. The elevated levels of ALT and route of HCV transmission were found to be significantly associated with the response to therapy in HCV-infected patients. Our findings may be useful for estimating a patients likelihood Of achieving sustained viral response.
T2  - Archives of Biological Sciences
T1  - Response Factors to Pegylated Interferon-Alfa/Ribavirin Treatment in Chronic Hepatitis C Patients Genotype 1b
VL  - 66
IS  - 1
SP  - 193
EP  - 201
DO  - 10.2298/ABS1401193J
ER  - 

@article{
author = "Jovanović-Ćupić, Snežana P. and Glišić, Sanja and Stanojevic, M. and Vasiljević, N. and Bojić, Tijana and Božović, Ana M. and Dimitrijević, Bogomir B.",
year = "2014",
abstract = "Hepatitis C virus infection is the most common chronic blood-borne infection and one of the most important causes of chronic liver disease. Knowing the predictors associated with pegylated interferon/ribavirin (PEG-IFN/RBV) combination therapy response is important for evidence-based treatment recommendations. The goal of this study was to identify host and viral factors of response to PEG-IFN/RBV treatment in chronic hepatitis C genotype 1b patients. We have examined the relationship between gender, age, level of alanine aminotransferase (ALT), viral load and liver fibrosis progression on therapy response. ALT level and viral load were evaluated before starting treatment with combination therapy. The elevated levels of ALT and route of HCV transmission were found to be significantly associated with the response to therapy in HCV-infected patients. Our findings may be useful for estimating a patients likelihood Of achieving sustained viral response.",
journal = "Archives of Biological Sciences",
title = "Response Factors to Pegylated Interferon-Alfa/Ribavirin Treatment in Chronic Hepatitis C Patients Genotype 1b",
volume = "66",
number = "1",
pages = "193-201",
doi = "10.2298/ABS1401193J"
}

Jovanović-Ćupić, S. P., Glišić, S., Stanojevic, M., Vasiljević, N., Bojić, T., Božović, A. M.,& Dimitrijević, B. B.. (2014). Response Factors to Pegylated Interferon-Alfa/Ribavirin Treatment in Chronic Hepatitis C Patients Genotype 1b. in Archives of Biological Sciences, 66(1), 193-201.
https://doi.org/10.2298/ABS1401193J

Jovanović-Ćupić SP, Glišić S, Stanojevic M, Vasiljević N, Bojić T, Božović AM, Dimitrijević BB. Response Factors to Pegylated Interferon-Alfa/Ribavirin Treatment in Chronic Hepatitis C Patients Genotype 1b. in Archives of Biological Sciences. 2014;66(1):193-201.
doi:10.2298/ABS1401193J .

Jovanović-Ćupić, Snežana P., Glišić, Sanja, Stanojevic, M., Vasiljević, N., Bojić, Tijana, Božović, Ana M., Dimitrijević, Bogomir B., "Response Factors to Pegylated Interferon-Alfa/Ribavirin Treatment in Chronic Hepatitis C Patients Genotype 1b" in Archives of Biological Sciences, 66, no. 1 (2014):193-201,
https://doi.org/10.2298/ABS1401193J . .

TY  - JOUR
AU  - Bojić, Tijana
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8864
AB  - Insomnia and sleep disorders represent health and social burden of developed countries. Percentage of burdened population varies from 23% in Japan, 31% in EU up to 56% in the USA. Social risk factors for insomnia are aging of population, awareness about personal illness, unemployment, and stress as a key factor. Personal consequences of insomnia include, first of all, psychological disturbances, than immunity break down, metabolic disturbances and cardiovascular diseases. Serbia is on the third place in Europe (after Russia and Ukraine) by the burden of cardiovascular diseases (410/100000 Europe, 504/100000 Serbia).By the circumstances that social ambient on one side and prevalence and dominance of cardiovascular diseases on the other side comprise, it is evident that insomnia represents unrecognized mortality risk factor in Serbia. Insomnia as the risk factor for cerebrocardiovascular diseases is neglected contributory factor to the development of these diseases in Serbia. The aim of this analytical research is to point on and mobilize action on this problem.
AB  - Nesanica i poremećaji spavanja predstavljaju zdravstveno pa i ekonomsko opterećenje tehnološki razvijenog sveta. Procenat stanovništva pogođenih ovim problemom kreće se od 23% u Japanu preko 31% u EU do 56% u SAD. Faktori rizika za nesanicu su starost populacije, svest o sopstvenom lošem zdravlju, nezaposlenost i stres kao ključni faktor rizika.Nesanica za pojedinca podrazumeva pre svega psihološke poremećaje, zatim poremećaj imuniteta, poremećaj metabolizma i kardiovaskularna oboljenja. Srbija se nalazi na prvom mestu u Evropi po smrtnosti od kardiovaskularnih poremećaja (410/100000 Evropa, 504/100000 Srbija). S obzirom na očigledne faktore rizika društvenog ambijenta i prevalence odnosno dominacije kardiovaskularnog oboljevanja na teritoriji Republike Srbije, očigledno je da nesanica postoji kao neprepoznati faktor rizika u nastanku za mortalitet populacije Srbije. Nesanica kao faktor rizika za kardiovaskularne i cerebrovaskularne bolesti je neobrađen element doprinosa manifestaciji ovih bolesti u Srbiji. Cilj analitičke studije je da se ovaj problem determiniše kao takav i da se pokrene praktična akcija u cilju njegovog rešavanja.
T2  - Engrami
T1  - Insomnia as a risk factor for cardiocerebrovascular disorders
T1  - Nesanica kao faktor rizika za kardiocerebrovaskularne bolesti
VL  - 36
IS  - 1-2
SP  - 31
EP  - 36
DO  - 10.5937/engrami1402031b
ER  - 

@article{
author = "Bojić, Tijana",
year = "2014",
abstract = "Insomnia and sleep disorders represent health and social burden of developed countries. Percentage of burdened population varies from 23% in Japan, 31% in EU up to 56% in the USA. Social risk factors for insomnia are aging of population, awareness about personal illness, unemployment, and stress as a key factor. Personal consequences of insomnia include, first of all, psychological disturbances, than immunity break down, metabolic disturbances and cardiovascular diseases. Serbia is on the third place in Europe (after Russia and Ukraine) by the burden of cardiovascular diseases (410/100000 Europe, 504/100000 Serbia).By the circumstances that social ambient on one side and prevalence and dominance of cardiovascular diseases on the other side comprise, it is evident that insomnia represents unrecognized mortality risk factor in Serbia. Insomnia as the risk factor for cerebrocardiovascular diseases is neglected contributory factor to the development of these diseases in Serbia. The aim of this analytical research is to point on and mobilize action on this problem., Nesanica i poremećaji spavanja predstavljaju zdravstveno pa i ekonomsko opterećenje tehnološki razvijenog sveta. Procenat stanovništva pogođenih ovim problemom kreće se od 23% u Japanu preko 31% u EU do 56% u SAD. Faktori rizika za nesanicu su starost populacije, svest o sopstvenom lošem zdravlju, nezaposlenost i stres kao ključni faktor rizika.Nesanica za pojedinca podrazumeva pre svega psihološke poremećaje, zatim poremećaj imuniteta, poremećaj metabolizma i kardiovaskularna oboljenja. Srbija se nalazi na prvom mestu u Evropi po smrtnosti od kardiovaskularnih poremećaja (410/100000 Evropa, 504/100000 Srbija). S obzirom na očigledne faktore rizika društvenog ambijenta i prevalence odnosno dominacije kardiovaskularnog oboljevanja na teritoriji Republike Srbije, očigledno je da nesanica postoji kao neprepoznati faktor rizika u nastanku za mortalitet populacije Srbije. Nesanica kao faktor rizika za kardiovaskularne i cerebrovaskularne bolesti je neobrađen element doprinosa manifestaciji ovih bolesti u Srbiji. Cilj analitičke studije je da se ovaj problem determiniše kao takav i da se pokrene praktična akcija u cilju njegovog rešavanja.",
journal = "Engrami",
title = "Insomnia as a risk factor for cardiocerebrovascular disorders, Nesanica kao faktor rizika za kardiocerebrovaskularne bolesti",
volume = "36",
number = "1-2",
pages = "31-36",
doi = "10.5937/engrami1402031b"
}

Bojić, T.. (2014). Insomnia as a risk factor for cardiocerebrovascular disorders. in Engrami, 36(1-2), 31-36.
https://doi.org/10.5937/engrami1402031b

Bojić T. Insomnia as a risk factor for cardiocerebrovascular disorders. in Engrami. 2014;36(1-2):31-36.
doi:10.5937/engrami1402031b .

Bojić, Tijana, "Insomnia as a risk factor for cardiocerebrovascular disorders" in Engrami, 36, no. 1-2 (2014):31-36,
https://doi.org/10.5937/engrami1402031b . .

TY  - JOUR
AU  - Maravić-Stojković, V.
AU  - Laušević-Vuk, L.J.
AU  - Jović, M.
AU  - Filipović, M.
AU  - Bojić, Tijana
AU  - Stojković, B.
AU  - Isenović, Esma R.
AU  - Đukanović, B.
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8866
AB  - Background: Procalcitonin (PCT) is a marker for sepsis diagnosis, identification of bacterial infection and monitoring of antibiotic therapy. It has been shown that PCT is not a good choice in patients with hemodialysis. Therefore, we have explored two biomarkers: a) presepsin, and, b) midregion-proadrenomedullin (MR-proADM) in patients having End-Stage Renal Disease (ESRD). Patients and Methods: We prospectively enlisted 20 patients, who underwent cardiovascular surgery and had been on dialysis. The diagnosis of sepsis has been established clinically and confirmed by PCT. Blood samples were taken before and after dialysis. Additionally, plasma and sera of 10 healthy blood donors without any complications were used as controls. Results: Presepsin plasma concentrations (4368 ± 3088 vs. 694.1 ± 239.1 pg/mL) were significantly higher in patients with sepsis compared with controls (p<0.0001), but without significance between survivors and nonsurvivors (p=0.77). Circulating levels of MR-proADM (4.15 ± 2.72 vs. 0.294 ± 0.03 nmol/L) were also elevated in ESRD patients (p>0.05) with no significance between alive and deceased (p=0.53) patients. Adjustments have shown that the difference for MR-proADM level is due to the random sampling variability (p=0.989), whereas difference for presepsin remained highly significant (p<0.001). Conclusions: Our results indicate that the accuracy of new biomarkers is equal to that of PCT in patients with ESRD. Presepsin might be as good marker in repeated measurements, before and after dialysis, as it is PCT. © 2014 Maravic-Stojkovic V, et al.
T2  - Journal of Clinical & Experimental Cardiology
T1  - Levels of Presepsin and Midregion-Proadrenomedullin in Septic Patients with End-Stage Renal Disease after Cardiovascular Surgery: 1-Year Follow Up Study
VL  - 5
IS  - 5
DO  - 10.4172/2155-9880.1000307
ER  - 

@article{
author = "Maravić-Stojković, V. and Laušević-Vuk, L.J. and Jović, M. and Filipović, M. and Bojić, Tijana and Stojković, B. and Isenović, Esma R. and Đukanović, B.",
year = "2014",
abstract = "Background: Procalcitonin (PCT) is a marker for sepsis diagnosis, identification of bacterial infection and monitoring of antibiotic therapy. It has been shown that PCT is not a good choice in patients with hemodialysis. Therefore, we have explored two biomarkers: a) presepsin, and, b) midregion-proadrenomedullin (MR-proADM) in patients having End-Stage Renal Disease (ESRD). Patients and Methods: We prospectively enlisted 20 patients, who underwent cardiovascular surgery and had been on dialysis. The diagnosis of sepsis has been established clinically and confirmed by PCT. Blood samples were taken before and after dialysis. Additionally, plasma and sera of 10 healthy blood donors without any complications were used as controls. Results: Presepsin plasma concentrations (4368 ± 3088 vs. 694.1 ± 239.1 pg/mL) were significantly higher in patients with sepsis compared with controls (p<0.0001), but without significance between survivors and nonsurvivors (p=0.77). Circulating levels of MR-proADM (4.15 ± 2.72 vs. 0.294 ± 0.03 nmol/L) were also elevated in ESRD patients (p>0.05) with no significance between alive and deceased (p=0.53) patients. Adjustments have shown that the difference for MR-proADM level is due to the random sampling variability (p=0.989), whereas difference for presepsin remained highly significant (p<0.001). Conclusions: Our results indicate that the accuracy of new biomarkers is equal to that of PCT in patients with ESRD. Presepsin might be as good marker in repeated measurements, before and after dialysis, as it is PCT. © 2014 Maravic-Stojkovic V, et al.",
journal = "Journal of Clinical & Experimental Cardiology",
title = "Levels of Presepsin and Midregion-Proadrenomedullin in Septic Patients with End-Stage Renal Disease after Cardiovascular Surgery: 1-Year Follow Up Study",
volume = "5",
number = "5",
doi = "10.4172/2155-9880.1000307"
}

Maravić-Stojković, V., Laušević-Vuk, L.J., Jović, M., Filipović, M., Bojić, T., Stojković, B., Isenović, E. R.,& Đukanović, B.. (2014). Levels of Presepsin and Midregion-Proadrenomedullin in Septic Patients with End-Stage Renal Disease after Cardiovascular Surgery: 1-Year Follow Up Study. in Journal of Clinical & Experimental Cardiology, 5(5).
https://doi.org/10.4172/2155-9880.1000307

Maravić-Stojković V, Laušević-Vuk L, Jović M, Filipović M, Bojić T, Stojković B, Isenović ER, Đukanović B. Levels of Presepsin and Midregion-Proadrenomedullin in Septic Patients with End-Stage Renal Disease after Cardiovascular Surgery: 1-Year Follow Up Study. in Journal of Clinical & Experimental Cardiology. 2014;5(5).
doi:10.4172/2155-9880.1000307 .

Maravić-Stojković, V., Laušević-Vuk, L.J., Jović, M., Filipović, M., Bojić, Tijana, Stojković, B., Isenović, Esma R., Đukanović, B., "Levels of Presepsin and Midregion-Proadrenomedullin in Septic Patients with End-Stage Renal Disease after Cardiovascular Surgery: 1-Year Follow Up Study" in Journal of Clinical & Experimental Cardiology, 5, no. 5 (2014),
https://doi.org/10.4172/2155-9880.1000307 . .