TY  - CONF
AU  - Keta, Otilija D.
AU  - Petković, Vladana
AU  - Đorđević, Neda O.
AU  - Đorđević, Miloš
AU  - Ivković, Branka
AU  - Dobričić, Vladimir
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12088
AB  - Given the well-established potential of chalcones in modulating the response of cancer cells to therapeutic interventions, coupled with the growing imperative to enhance their biological attributes, the objective of this study was to synthesize a methoxy-substituted chalcone (OCH3) and assess its capacity to amplify the inhibitory effects of radiation in melanoma cells known for their resistance to radiotherapy. The A375 melanoma cells were subjected to a clinically relevant dose of 2 Gy gamma irradiation. OCH3 was employed either as a standalone treatment or in conjunction with irradiation. The obtained results unveiled the substantial radiosensitizing potential of OCH3 within this specific cell line. Our subsequent investigations will be designed to investigate the underlying mechanisms that contribute to the radiosensitizing properties of OCH3. Moreover, we intend to evaluate the efficacy of OCH3 against other types of radioresistant cancer cells. The presented data not only illuminates the enhanced therapeutic possibilities offered by OCH3 but also highlights its potential as a valuable agent in addressing a wider array of challenging malignancies.
PB  - Kragujevac : Institute for Information Technologies, University of Kragujevac
C3  - ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings
T1  - The effects of a selected methoxy substituted chalcone in human melanoma cells irradiated with γ-rays
SP  - 471
EP  - 474
DO  - 10.46793/ICCBI23.471K
ER  - 

@conference{
author = "Keta, Otilija D. and Petković, Vladana and Đorđević, Neda O. and Đorđević, Miloš and Ivković, Branka and Dobričić, Vladimir",
year = "2023",
abstract = "Given the well-established potential of chalcones in modulating the response of cancer cells to therapeutic interventions, coupled with the growing imperative to enhance their biological attributes, the objective of this study was to synthesize a methoxy-substituted chalcone (OCH3) and assess its capacity to amplify the inhibitory effects of radiation in melanoma cells known for their resistance to radiotherapy. The A375 melanoma cells were subjected to a clinically relevant dose of 2 Gy gamma irradiation. OCH3 was employed either as a standalone treatment or in conjunction with irradiation. The obtained results unveiled the substantial radiosensitizing potential of OCH3 within this specific cell line. Our subsequent investigations will be designed to investigate the underlying mechanisms that contribute to the radiosensitizing properties of OCH3. Moreover, we intend to evaluate the efficacy of OCH3 against other types of radioresistant cancer cells. The presented data not only illuminates the enhanced therapeutic possibilities offered by OCH3 but also highlights its potential as a valuable agent in addressing a wider array of challenging malignancies.",
publisher = "Kragujevac : Institute for Information Technologies, University of Kragujevac",
journal = "ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings",
title = "The effects of a selected methoxy substituted chalcone in human melanoma cells irradiated with γ-rays",
pages = "471-474",
doi = "10.46793/ICCBI23.471K"
}

Keta, O. D., Petković, V., Đorđević, N. O., Đorđević, M., Ivković, B.,& Dobričić, V.. (2023). The effects of a selected methoxy substituted chalcone in human melanoma cells irradiated with γ-rays. in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings
Kragujevac : Institute for Information Technologies, University of Kragujevac., 471-474.
https://doi.org/10.46793/ICCBI23.471K

Keta OD, Petković V, Đorđević NO, Đorđević M, Ivković B, Dobričić V. The effects of a selected methoxy substituted chalcone in human melanoma cells irradiated with γ-rays. in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings. 2023;:471-474.
doi:10.46793/ICCBI23.471K .

Keta, Otilija D., Petković, Vladana, Đorđević, Neda O., Đorđević, Miloš, Ivković, Branka, Dobričić, Vladimir, "The effects of a selected methoxy substituted chalcone in human melanoma cells irradiated with γ-rays" in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings (2023):471-474,
https://doi.org/10.46793/ICCBI23.471K . .