TY  - JOUR
AU  - Jovanović, Dušica
AU  - Zagorac, Dejan
AU  - Schön, Johann Christian
AU  - Milovanović, Branislav
AU  - Zagorac, Jelena B.
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8674
AB  - Due to their great importance in science, technology, and the life sciences, water and ice have been extensively investigated over many years. In particular, hexagonal ice Ih has been of great interest since it is the most common form of ice, and several modifications, Ih(a), Ih(b) and Ih(c) are known, whose structural details are still under discussion. In this study, we present an alternative theoretical model, called Ih(d), for the hexagonal ice modification in space group P 6 3 / mmc (no. 194), based on first-principles calculations that have been performed using DFT-LDA, GGA-PBE, and hybrid B3LYP and PBE0 functionals.
T2  - Zeitschrift fur Naturforschung. Section B: Journal of Chemical Sciences
T1  - A new theoretical model for hexagonal ice, Ih(d), from first principles investigations
VL  - 75
IS  - 1-2
SP  - 125
EP  - 128
DO  - 10.1515/znb-2019-0164
ER  - 

@article{
author = "Jovanović, Dušica and Zagorac, Dejan and Schön, Johann Christian and Milovanović, Branislav and Zagorac, Jelena B.",
year = "2020",
abstract = "Due to their great importance in science, technology, and the life sciences, water and ice have been extensively investigated over many years. In particular, hexagonal ice Ih has been of great interest since it is the most common form of ice, and several modifications, Ih(a), Ih(b) and Ih(c) are known, whose structural details are still under discussion. In this study, we present an alternative theoretical model, called Ih(d), for the hexagonal ice modification in space group P 6 3 / mmc (no. 194), based on first-principles calculations that have been performed using DFT-LDA, GGA-PBE, and hybrid B3LYP and PBE0 functionals.",
journal = "Zeitschrift fur Naturforschung. Section B: Journal of Chemical Sciences",
title = "A new theoretical model for hexagonal ice, Ih(d), from first principles investigations",
volume = "75",
number = "1-2",
pages = "125-128",
doi = "10.1515/znb-2019-0164"
}

Jovanović, D., Zagorac, D., Schön, J. C., Milovanović, B.,& Zagorac, J. B.. (2020). A new theoretical model for hexagonal ice, Ih(d), from first principles investigations. in Zeitschrift fur Naturforschung. Section B: Journal of Chemical Sciences, 75(1-2), 125-128.
https://doi.org/10.1515/znb-2019-0164

Jovanović D, Zagorac D, Schön JC, Milovanović B, Zagorac JB. A new theoretical model for hexagonal ice, Ih(d), from first principles investigations. in Zeitschrift fur Naturforschung. Section B: Journal of Chemical Sciences. 2020;75(1-2):125-128.
doi:10.1515/znb-2019-0164 .

Jovanović, Dušica, Zagorac, Dejan, Schön, Johann Christian, Milovanović, Branislav, Zagorac, Jelena B., "A new theoretical model for hexagonal ice, Ih(d), from first principles investigations" in Zeitschrift fur Naturforschung. Section B: Journal of Chemical Sciences, 75, no. 1-2 (2020):125-128,
https://doi.org/10.1515/znb-2019-0164 . .

TY  - CONF
AU  - Životić, Ivan
AU  - Kolić, Ivana
AU  - Đurić, Tamara
AU  - Živković, Maja
AU  - Milovanović, Branislav
AU  - Stanković, Aleksandra
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12682
AB  - Introduction: The autonomic nervous system (ANS), plays an essential role in the regulation of vascular wall contractility, heart rate and blood pressure (BP) variability. The symptoms of ANS dysfunction were strongly associated with vasovagal syncope (VVS). The renin-angiotensin system (RAS) is a powerful feedback system responsible for long-term control of cardiovascular hemodynamic values, heart rate and BP homeostasis. All components of the RAS have been detected in the brain as well as in the cardiovascular system, with central and peripheral actions of angiotensin II main effector molecule synthesized by angiotensin converting enzyme (ACE). Opposite influences of angiotensin II (AngII) receptor type 1 (AT1R) and angiotensin II receptor type 2 (ATR2) on sympathetic tone have been documented. Genetic studies have shown that individuals with VVS usually have a positive family history. Still, the genetic basis of VVS is unclear. The aim of the study was to investigate the association of the RAS gene variants, ACE I/D, AT1R A1166C and ATR2 -1332 A/G with the VVS in Serbian population. Methods: This case-control designed study included 215 VVS patients and 439 controls (C) matched by age (mean±SD, VVS: 38,25±13,52 years and C: 36,63±11,69 years). Genotyping was done by PCR-RFLP and allele specific PCR methods. Results: There were no significant differences in the genotype frequency distributions of ACE I/D and AT1R A1166C variants between cases and controls (p=0.4 and p=0.2, respectively). With regard to X-linked ATR2 -1332 A/G variant the frequency of A/- hemizygotes was significantly higher in VVS than in controls, in males (p=0.01). In females there were no differences in genotype frequency distributions between cases and controls (p=0.73). Conclusions: Our results suggest further investigation of AT2R hemodynamic effect on AngII in VVS males. To accurately elucidate given association, replication of the results in a larger sample is inevitable.
C3  - ICE 2019 : International Congress on Electrocardiology : Joint Meeting of ISHNE and ISE : Book of abstracts
T1  - Renin-angiotensin system gene variants in association with vasovagal syncope in Serbian population
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12682
ER  - 

@conference{
author = "Životić, Ivan and Kolić, Ivana and Đurić, Tamara and Živković, Maja and Milovanović, Branislav and Stanković, Aleksandra",
year = "2019",
abstract = "Introduction: The autonomic nervous system (ANS), plays an essential role in the regulation of vascular wall contractility, heart rate and blood pressure (BP) variability. The symptoms of ANS dysfunction were strongly associated with vasovagal syncope (VVS). The renin-angiotensin system (RAS) is a powerful feedback system responsible for long-term control of cardiovascular hemodynamic values, heart rate and BP homeostasis. All components of the RAS have been detected in the brain as well as in the cardiovascular system, with central and peripheral actions of angiotensin II main effector molecule synthesized by angiotensin converting enzyme (ACE). Opposite influences of angiotensin II (AngII) receptor type 1 (AT1R) and angiotensin II receptor type 2 (ATR2) on sympathetic tone have been documented. Genetic studies have shown that individuals with VVS usually have a positive family history. Still, the genetic basis of VVS is unclear. The aim of the study was to investigate the association of the RAS gene variants, ACE I/D, AT1R A1166C and ATR2 -1332 A/G with the VVS in Serbian population. Methods: This case-control designed study included 215 VVS patients and 439 controls (C) matched by age (mean±SD, VVS: 38,25±13,52 years and C: 36,63±11,69 years). Genotyping was done by PCR-RFLP and allele specific PCR methods. Results: There were no significant differences in the genotype frequency distributions of ACE I/D and AT1R A1166C variants between cases and controls (p=0.4 and p=0.2, respectively). With regard to X-linked ATR2 -1332 A/G variant the frequency of A/- hemizygotes was significantly higher in VVS than in controls, in males (p=0.01). In females there were no differences in genotype frequency distributions between cases and controls (p=0.73). Conclusions: Our results suggest further investigation of AT2R hemodynamic effect on AngII in VVS males. To accurately elucidate given association, replication of the results in a larger sample is inevitable.",
journal = "ICE 2019 : International Congress on Electrocardiology : Joint Meeting of ISHNE and ISE : Book of abstracts",
title = "Renin-angiotensin system gene variants in association with vasovagal syncope in Serbian population",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12682"
}

Životić, I., Kolić, I., Đurić, T., Živković, M., Milovanović, B.,& Stanković, A.. (2019). Renin-angiotensin system gene variants in association with vasovagal syncope in Serbian population. in ICE 2019 : International Congress on Electrocardiology : Joint Meeting of ISHNE and ISE : Book of abstracts.
https://hdl.handle.net/21.15107/rcub_vinar_12682

Životić I, Kolić I, Đurić T, Živković M, Milovanović B, Stanković A. Renin-angiotensin system gene variants in association with vasovagal syncope in Serbian population. in ICE 2019 : International Congress on Electrocardiology : Joint Meeting of ISHNE and ISE : Book of abstracts. 2019;.
https://hdl.handle.net/21.15107/rcub_vinar_12682 .

Životić, Ivan, Kolić, Ivana, Đurić, Tamara, Živković, Maja, Milovanović, Branislav, Stanković, Aleksandra, "Renin-angiotensin system gene variants in association with vasovagal syncope in Serbian population" in ICE 2019 : International Congress on Electrocardiology : Joint Meeting of ISHNE and ISE : Book of abstracts (2019),
https://hdl.handle.net/21.15107/rcub_vinar_12682 .

TY  - CONF
AU  - Kolić, Ivana
AU  - Životić, Ivan
AU  - Đurić, Tamara
AU  - Živković, Maja
AU  - Alavantić, Dragan
AU  - Jovanović, Dušica
AU  - Milovanović, Branislav
AU  - Stanković, Aleksandra
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12683
AB  - Background: Disturbance in sympathovagal balance were strongly associated withoccurrence of syncope.The renin-angiotensin system (RAS) interacts with the autonomous nervous system (ANS) in the regulation of blood pressure and cardiovascular function. By now, several genetic variants in the RAS have been identified as factors in alteration of HRV parameters, haemodynamic values,heart rate, and BP.The aim of our study was to investigate the association of ACE I/D, AGTR1 +1166A/C and AGTR2 -1332A/G gene variants and ANS function. Methods: This study included 215 syncope patients (age (mean±SD)=38.15±13.52 years, 79% females and 21% males) whose ANS function was evaluated by power spectral analysis of heart rate variability (HRV) before and during Tilt test (TT). Genotyping was done by PCR-RFLP and allele specific PCR methods. Statistical analysis was performed using STATISTICA data analysis software system (StatSoft, Inc. (2007). STATISTICA, version 8.0. www.statsoft.com). Results: There were no significant associations of ACE I/D or AGTR2 -1332A/G gene variants with the level of HRV parameters. We found that homozygotic carriers of both AGTR1 +1166A/C alleles have significantly increased LF component in supine position before TT, compared to heterozygote carriers (p=0,04, Mann-Whitney U test). During the TT there were no significant diferences in level of LF component with regard to AGTR1 +1166A/C genotypes. Conclusions: The present study suggest association of AGTR1 +1166A/C variant with LF component adrressing predisposition to syncopal event during TT. This association need to be confirmed in further genetic association studies on a larger sample.
C3  - ICE 2019 : International Congress on Electrocardiology : Joint Meeting of ISHNE and ISE : Book of abstracts
T1  - Association of ACE I/D, AGTR1 +1166A/C and AGTR2 -1332A/G gene variants with autonomous nervous system function in Serbian syncope patients
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12683
ER  - 

@conference{
author = "Kolić, Ivana and Životić, Ivan and Đurić, Tamara and Živković, Maja and Alavantić, Dragan and Jovanović, Dušica and Milovanović, Branislav and Stanković, Aleksandra",
year = "2019",
abstract = "Background: Disturbance in sympathovagal balance were strongly associated withoccurrence of syncope.The renin-angiotensin system (RAS) interacts with the autonomous nervous system (ANS) in the regulation of blood pressure and cardiovascular function. By now, several genetic variants in the RAS have been identified as factors in alteration of HRV parameters, haemodynamic values,heart rate, and BP.The aim of our study was to investigate the association of ACE I/D, AGTR1 +1166A/C and AGTR2 -1332A/G gene variants and ANS function. Methods: This study included 215 syncope patients (age (mean±SD)=38.15±13.52 years, 79% females and 21% males) whose ANS function was evaluated by power spectral analysis of heart rate variability (HRV) before and during Tilt test (TT). Genotyping was done by PCR-RFLP and allele specific PCR methods. Statistical analysis was performed using STATISTICA data analysis software system (StatSoft, Inc. (2007). STATISTICA, version 8.0. www.statsoft.com). Results: There were no significant associations of ACE I/D or AGTR2 -1332A/G gene variants with the level of HRV parameters. We found that homozygotic carriers of both AGTR1 +1166A/C alleles have significantly increased LF component in supine position before TT, compared to heterozygote carriers (p=0,04, Mann-Whitney U test). During the TT there were no significant diferences in level of LF component with regard to AGTR1 +1166A/C genotypes. Conclusions: The present study suggest association of AGTR1 +1166A/C variant with LF component adrressing predisposition to syncopal event during TT. This association need to be confirmed in further genetic association studies on a larger sample.",
journal = "ICE 2019 : International Congress on Electrocardiology : Joint Meeting of ISHNE and ISE : Book of abstracts",
title = "Association of ACE I/D, AGTR1 +1166A/C and AGTR2 -1332A/G gene variants with autonomous nervous system function in Serbian syncope patients",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12683"
}

Kolić, I., Životić, I., Đurić, T., Živković, M., Alavantić, D., Jovanović, D., Milovanović, B.,& Stanković, A.. (2019). Association of ACE I/D, AGTR1 +1166A/C and AGTR2 -1332A/G gene variants with autonomous nervous system function in Serbian syncope patients. in ICE 2019 : International Congress on Electrocardiology : Joint Meeting of ISHNE and ISE : Book of abstracts.
https://hdl.handle.net/21.15107/rcub_vinar_12683

Kolić I, Životić I, Đurić T, Živković M, Alavantić D, Jovanović D, Milovanović B, Stanković A. Association of ACE I/D, AGTR1 +1166A/C and AGTR2 -1332A/G gene variants with autonomous nervous system function in Serbian syncope patients. in ICE 2019 : International Congress on Electrocardiology : Joint Meeting of ISHNE and ISE : Book of abstracts. 2019;.
https://hdl.handle.net/21.15107/rcub_vinar_12683 .

Kolić, Ivana, Životić, Ivan, Đurić, Tamara, Živković, Maja, Alavantić, Dragan, Jovanović, Dušica, Milovanović, Branislav, Stanković, Aleksandra, "Association of ACE I/D, AGTR1 +1166A/C and AGTR2 -1332A/G gene variants with autonomous nervous system function in Serbian syncope patients" in ICE 2019 : International Congress on Electrocardiology : Joint Meeting of ISHNE and ISE : Book of abstracts (2019),
https://hdl.handle.net/21.15107/rcub_vinar_12683 .

TY  - JOUR
AU  - Milovanović, Branislav
AU  - Milovanović, Milan
AU  - Veličković, Suzana
AU  - Veljković, Filip M.
AU  - Perić-Grujić, Aleksandra A.
AU  - Jerosimić, Stanka
PY  - 2019
UR  - https://onlinelibrary.wiley.com/doi/abs/10.1002/qua.26009
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8352
AB  - Small heterogeneous potassium-iodide clusters are investigated by means of ab initio electronic structural methods together with experimental production and detection in mass spectrometry. Experiments were done by using Knudsen cell mass spectrometry (KCMS) modification method, which provided simultaneous generating of all KnI0,+1 (n = 2–6) clusters at once. Clusters with more than two potassium atoms are produced for the first time. The lowest lying isomers of those KnI0,+1 (n = 2–6) clusters were found by using a random-kick procedure. The best description of growth of these clusters is the addition of one potassium atom to a smaller-neighbor cluster. Subsequently, stability of these species was examined. In spite of general trend of decreasing of binding energies, the closed-shell species have slightly larger stability with respect to the open-shell species. Alternation of dissociation energies between closed-shell and open-shell clusters is presented. Experimental setup also allows determination of ionization energies of clusters: the obtained values are in the range of 3.46–3.98 eV, which classify these clusters as “superalkali.” For closed-shell clusters, the theoretical adiabatic ionization energies are close to experimental values, whereas in the case of open-shell clusters, the vertical ionization energies are those that are close to experimental values. © 2019 Wiley Periodicals, Inc.
T2  - International Journal of Quantum Chemistry
T1  - Theoretical and experimental investigation of geometry and stability of small potassium‐iodide KnI(n=2–6) clusters
VL  - 119
IS  - 22
SP  - e26009
DO  - 10.1002/qua.26009
ER  - 

@article{
author = "Milovanović, Branislav and Milovanović, Milan and Veličković, Suzana and Veljković, Filip M. and Perić-Grujić, Aleksandra A. and Jerosimić, Stanka",
year = "2019",
abstract = "Small heterogeneous potassium-iodide clusters are investigated by means of ab initio electronic structural methods together with experimental production and detection in mass spectrometry. Experiments were done by using Knudsen cell mass spectrometry (KCMS) modification method, which provided simultaneous generating of all KnI0,+1 (n = 2–6) clusters at once. Clusters with more than two potassium atoms are produced for the first time. The lowest lying isomers of those KnI0,+1 (n = 2–6) clusters were found by using a random-kick procedure. The best description of growth of these clusters is the addition of one potassium atom to a smaller-neighbor cluster. Subsequently, stability of these species was examined. In spite of general trend of decreasing of binding energies, the closed-shell species have slightly larger stability with respect to the open-shell species. Alternation of dissociation energies between closed-shell and open-shell clusters is presented. Experimental setup also allows determination of ionization energies of clusters: the obtained values are in the range of 3.46–3.98 eV, which classify these clusters as “superalkali.” For closed-shell clusters, the theoretical adiabatic ionization energies are close to experimental values, whereas in the case of open-shell clusters, the vertical ionization energies are those that are close to experimental values. © 2019 Wiley Periodicals, Inc.",
journal = "International Journal of Quantum Chemistry",
title = "Theoretical and experimental investigation of geometry and stability of small potassium‐iodide KnI(n=2–6) clusters",
volume = "119",
number = "22",
pages = "e26009",
doi = "10.1002/qua.26009"
}

Milovanović, B., Milovanović, M., Veličković, S., Veljković, F. M., Perić-Grujić, A. A.,& Jerosimić, S.. (2019). Theoretical and experimental investigation of geometry and stability of small potassium‐iodide KnI(n=2–6) clusters. in International Journal of Quantum Chemistry, 119(22), e26009.
https://doi.org/10.1002/qua.26009

Milovanović B, Milovanović M, Veličković S, Veljković FM, Perić-Grujić AA, Jerosimić S. Theoretical and experimental investigation of geometry and stability of small potassium‐iodide KnI(n=2–6) clusters. in International Journal of Quantum Chemistry. 2019;119(22):e26009.
doi:10.1002/qua.26009 .

Milovanović, Branislav, Milovanović, Milan, Veličković, Suzana, Veljković, Filip M., Perić-Grujić, Aleksandra A., Jerosimić, Stanka, "Theoretical and experimental investigation of geometry and stability of small potassium‐iodide KnI(n=2–6) clusters" in International Journal of Quantum Chemistry, 119, no. 22 (2019):e26009,
https://doi.org/10.1002/qua.26009 . .

TY  - JOUR
AU  - Pinkney, T.
AU  - Gvozdenović, M.
AU  - Jovanović, Dragana J.
AU  - Lausevic, Z.
AU  - Cvetković, D.
AU  - Maravic, M.
AU  - Milovanović, Branislav
AU  - Stojakovic, N.
AU  - Tripkovic, I.
AU  - Mihajlovic, D.
AU  - Nestorović, M.
AU  - Pecic, V.
AU  - Petrović, D.
AU  - Stanojevic, G.
AU  - Barisic, G.
AU  - Dimitrijevic, I.
AU  - Krivokapic, Z.
AU  - Markovic, V.
AU  - Popović, Milan
AU  - Aleksić, A.
AU  - Dabic, D.
AU  - Kostic, I.
AU  - Milojkovic, A.
AU  - Perunicic, V.
AU  - Lukić, Dejan
AU  - Petrović, T.
AU  - Radovanovic, D.
AU  - Radovanovic, Z.
AU  - Cuk, V. M.
AU  - Cuk, V. V.
AU  - Kenic, M.
AU  - Kovacevic, B.
AU  - Krdzic, I.
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1667
AB  - Aim The anastomosis technique used following right-sided colonic resection is widely variable and may affect patient outcome. This study aimed to assess the association between leak and anastomosis technique (stapled vs handsewn). Method This was a prospective, multicentre, international audit including patients undergoing elective or emergency right hemicolectomy or ileo-caecal resection operations over a 2-month period in early 2015. The primary outcome measure was the presence of anastomotic leak within 30 days of surgery, determined using a prespecified definition. Mixed effects logistic regression models were used to assess the association between leak and anastomosis method, adjusting for patient, disease and operative cofactors, with centre included as a random-effect variable. Results This study included 3208 patients, of whom 78.4% (n = 2515) underwent surgery for malignancy and 11.7% (n = 375) underwent surgery for Crohns disease. An anastomosis was performed in 94.8% (n = 3041) of patients, which was handsewn in 38.9% (n = 1183) and stapled in 61.1% (n = 1858). Patients undergoing hand-sewn anastomosis were more likely to be emergency admissions (20.5% handsewn vs 12.9% stapled) and to undergo open surgery (54.7% handsewn vs 36.6% stapled). The overall anastomotic leak rate was 8.1% (245/3041), which was similar following handsewn (7.4%) and stapled (8.5%) techniques (P = 0.3). After adjustment for cofactors, the odds of a leak were higher for stapled anastomosis (adjusted OR = 1.43; 95% CI: 1.04-1.95; P = 0.03). Conclusion Despite being used in lower-risk patients, stapled anastomosis was associated with an increased anastomotic leak rate in this observational study. Further research is needed to define patient groups in whom a stapled anastomosis is safe.
T2  - Colorectal Disease
T1  - Relationship between method of anastomosis and anastomotic failure after right hemicolectomy and ileo-caecal resection: an international snapshot audit
VL  - 19
IS  - 8
SP  - O296
EP  - O311
DO  - 10.1111/codi.13646
ER  - 

@article{
author = "Pinkney, T. and Gvozdenović, M. and Jovanović, Dragana J. and Lausevic, Z. and Cvetković, D. and Maravic, M. and Milovanović, Branislav and Stojakovic, N. and Tripkovic, I. and Mihajlovic, D. and Nestorović, M. and Pecic, V. and Petrović, D. and Stanojevic, G. and Barisic, G. and Dimitrijevic, I. and Krivokapic, Z. and Markovic, V. and Popović, Milan and Aleksić, A. and Dabic, D. and Kostic, I. and Milojkovic, A. and Perunicic, V. and Lukić, Dejan and Petrović, T. and Radovanovic, D. and Radovanovic, Z. and Cuk, V. M. and Cuk, V. V. and Kenic, M. and Kovacevic, B. and Krdzic, I.",
year = "2017",
abstract = "Aim The anastomosis technique used following right-sided colonic resection is widely variable and may affect patient outcome. This study aimed to assess the association between leak and anastomosis technique (stapled vs handsewn). Method This was a prospective, multicentre, international audit including patients undergoing elective or emergency right hemicolectomy or ileo-caecal resection operations over a 2-month period in early 2015. The primary outcome measure was the presence of anastomotic leak within 30 days of surgery, determined using a prespecified definition. Mixed effects logistic regression models were used to assess the association between leak and anastomosis method, adjusting for patient, disease and operative cofactors, with centre included as a random-effect variable. Results This study included 3208 patients, of whom 78.4% (n = 2515) underwent surgery for malignancy and 11.7% (n = 375) underwent surgery for Crohns disease. An anastomosis was performed in 94.8% (n = 3041) of patients, which was handsewn in 38.9% (n = 1183) and stapled in 61.1% (n = 1858). Patients undergoing hand-sewn anastomosis were more likely to be emergency admissions (20.5% handsewn vs 12.9% stapled) and to undergo open surgery (54.7% handsewn vs 36.6% stapled). The overall anastomotic leak rate was 8.1% (245/3041), which was similar following handsewn (7.4%) and stapled (8.5%) techniques (P = 0.3). After adjustment for cofactors, the odds of a leak were higher for stapled anastomosis (adjusted OR = 1.43; 95% CI: 1.04-1.95; P = 0.03). Conclusion Despite being used in lower-risk patients, stapled anastomosis was associated with an increased anastomotic leak rate in this observational study. Further research is needed to define patient groups in whom a stapled anastomosis is safe.",
journal = "Colorectal Disease",
title = "Relationship between method of anastomosis and anastomotic failure after right hemicolectomy and ileo-caecal resection: an international snapshot audit",
volume = "19",
number = "8",
pages = "O296-O311",
doi = "10.1111/codi.13646"
}

Pinkney, T., Gvozdenović, M., Jovanović, D. J., Lausevic, Z., Cvetković, D., Maravic, M., Milovanović, B., Stojakovic, N., Tripkovic, I., Mihajlovic, D., Nestorović, M., Pecic, V., Petrović, D., Stanojevic, G., Barisic, G., Dimitrijevic, I., Krivokapic, Z., Markovic, V., Popović, M., Aleksić, A., Dabic, D., Kostic, I., Milojkovic, A., Perunicic, V., Lukić, D., Petrović, T., Radovanovic, D., Radovanovic, Z., Cuk, V. M., Cuk, V. V., Kenic, M., Kovacevic, B.,& Krdzic, I.. (2017). Relationship between method of anastomosis and anastomotic failure after right hemicolectomy and ileo-caecal resection: an international snapshot audit. in Colorectal Disease, 19(8), O296-O311.
https://doi.org/10.1111/codi.13646

Pinkney T, Gvozdenović M, Jovanović DJ, Lausevic Z, Cvetković D, Maravic M, Milovanović B, Stojakovic N, Tripkovic I, Mihajlovic D, Nestorović M, Pecic V, Petrović D, Stanojevic G, Barisic G, Dimitrijevic I, Krivokapic Z, Markovic V, Popović M, Aleksić A, Dabic D, Kostic I, Milojkovic A, Perunicic V, Lukić D, Petrović T, Radovanovic D, Radovanovic Z, Cuk VM, Cuk VV, Kenic M, Kovacevic B, Krdzic I. Relationship between method of anastomosis and anastomotic failure after right hemicolectomy and ileo-caecal resection: an international snapshot audit. in Colorectal Disease. 2017;19(8):O296-O311.
doi:10.1111/codi.13646 .

Pinkney, T., Gvozdenović, M., Jovanović, Dragana J., Lausevic, Z., Cvetković, D., Maravic, M., Milovanović, Branislav, Stojakovic, N., Tripkovic, I., Mihajlovic, D., Nestorović, M., Pecic, V., Petrović, D., Stanojevic, G., Barisic, G., Dimitrijevic, I., Krivokapic, Z., Markovic, V., Popović, Milan, Aleksić, A., Dabic, D., Kostic, I., Milojkovic, A., Perunicic, V., Lukić, Dejan, Petrović, T., Radovanovic, D., Radovanovic, Z., Cuk, V. M., Cuk, V. V., Kenic, M., Kovacevic, B., Krdzic, I., "Relationship between method of anastomosis and anastomotic failure after right hemicolectomy and ileo-caecal resection: an international snapshot audit" in Colorectal Disease, 19, no. 8 (2017):O296-O311,
https://doi.org/10.1111/codi.13646 . .

TY  - CONF
AU  - Životić, Ivan
AU  - Đurić-Delić, Tamara
AU  - Živković, Maja
AU  - Bojić, Tijana
AU  - Milovanović, Branislav
AU  - Alavantić, Dragan
AU  - Stanković, Aleksandra
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11401
PB  - Belgrade : Serbian Neurocardiological Society
C3  - NEUROCARD 2015 : 7th Congress of Serbian neuroscience society with international participation, 6th International Symposium on Noninvasive Electrocardiology :  Program and the book of abstracts
T1  - The eNOS rs1799983 gene polymorphism (Glu298Asp) in association with cardiovascular profiles in patients with vasovagal syncope
SP  - 33
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11401
ER  - 

@conference{
author = "Životić, Ivan and Đurić-Delić, Tamara and Živković, Maja and Bojić, Tijana and Milovanović, Branislav and Alavantić, Dragan and Stanković, Aleksandra",
year = "2015",
publisher = "Belgrade : Serbian Neurocardiological Society",
journal = "NEUROCARD 2015 : 7th Congress of Serbian neuroscience society with international participation, 6th International Symposium on Noninvasive Electrocardiology :  Program and the book of abstracts",
title = "The eNOS rs1799983 gene polymorphism (Glu298Asp) in association with cardiovascular profiles in patients with vasovagal syncope",
pages = "33",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11401"
}

Životić, I., Đurić-Delić, T., Živković, M., Bojić, T., Milovanović, B., Alavantić, D.,& Stanković, A.. (2015). The eNOS rs1799983 gene polymorphism (Glu298Asp) in association with cardiovascular profiles in patients with vasovagal syncope. in NEUROCARD 2015 : 7th Congress of Serbian neuroscience society with international participation, 6th International Symposium on Noninvasive Electrocardiology :  Program and the book of abstracts
Belgrade : Serbian Neurocardiological Society., 33.
https://hdl.handle.net/21.15107/rcub_vinar_11401

Životić I, Đurić-Delić T, Živković M, Bojić T, Milovanović B, Alavantić D, Stanković A. The eNOS rs1799983 gene polymorphism (Glu298Asp) in association with cardiovascular profiles in patients with vasovagal syncope. in NEUROCARD 2015 : 7th Congress of Serbian neuroscience society with international participation, 6th International Symposium on Noninvasive Electrocardiology :  Program and the book of abstracts. 2015;:33.
https://hdl.handle.net/21.15107/rcub_vinar_11401 .

Životić, Ivan, Đurić-Delić, Tamara, Živković, Maja, Bojić, Tijana, Milovanović, Branislav, Alavantić, Dragan, Stanković, Aleksandra, "The eNOS rs1799983 gene polymorphism (Glu298Asp) in association with cardiovascular profiles in patients with vasovagal syncope" in NEUROCARD 2015 : 7th Congress of Serbian neuroscience society with international participation, 6th International Symposium on Noninvasive Electrocardiology :  Program and the book of abstracts (2015):33,
https://hdl.handle.net/21.15107/rcub_vinar_11401 .

TY  - CONF
AU  - Živković, Maja
AU  - Životić, Ivan
AU  - Bošković, Maja
AU  - Milovanović, Branislav
AU  - Bojić, Tijana
AU  - Alavantić, Dragan
AU  - Stanković, Aleksandra
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11402
PB  - Belgrade : Serbian Neurocardiological Society
C3  - NEUROCARD 2015 : 7th Congress of Serbian neuroscience society with international participation, 6th International Symposium on Noninvasive Electrocardiology :  Program and the book of abstracts
T1  - Effects of glutathione S-transferase T1 and M1 deletions on electrocardiographic and heart rate variability parameters in patients with vasovagal syncope
SP  - 34
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11402
ER  - 

@conference{
author = "Živković, Maja and Životić, Ivan and Bošković, Maja and Milovanović, Branislav and Bojić, Tijana and Alavantić, Dragan and Stanković, Aleksandra",
year = "2015",
publisher = "Belgrade : Serbian Neurocardiological Society",
journal = "NEUROCARD 2015 : 7th Congress of Serbian neuroscience society with international participation, 6th International Symposium on Noninvasive Electrocardiology :  Program and the book of abstracts",
title = "Effects of glutathione S-transferase T1 and M1 deletions on electrocardiographic and heart rate variability parameters in patients with vasovagal syncope",
pages = "34",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11402"
}

Živković, M., Životić, I., Bošković, M., Milovanović, B., Bojić, T., Alavantić, D.,& Stanković, A.. (2015). Effects of glutathione S-transferase T1 and M1 deletions on electrocardiographic and heart rate variability parameters in patients with vasovagal syncope. in NEUROCARD 2015 : 7th Congress of Serbian neuroscience society with international participation, 6th International Symposium on Noninvasive Electrocardiology :  Program and the book of abstracts
Belgrade : Serbian Neurocardiological Society., 34.
https://hdl.handle.net/21.15107/rcub_vinar_11402

Živković M, Životić I, Bošković M, Milovanović B, Bojić T, Alavantić D, Stanković A. Effects of glutathione S-transferase T1 and M1 deletions on electrocardiographic and heart rate variability parameters in patients with vasovagal syncope. in NEUROCARD 2015 : 7th Congress of Serbian neuroscience society with international participation, 6th International Symposium on Noninvasive Electrocardiology :  Program and the book of abstracts. 2015;:34.
https://hdl.handle.net/21.15107/rcub_vinar_11402 .

Živković, Maja, Životić, Ivan, Bošković, Maja, Milovanović, Branislav, Bojić, Tijana, Alavantić, Dragan, Stanković, Aleksandra, "Effects of glutathione S-transferase T1 and M1 deletions on electrocardiographic and heart rate variability parameters in patients with vasovagal syncope" in NEUROCARD 2015 : 7th Congress of Serbian neuroscience society with international participation, 6th International Symposium on Noninvasive Electrocardiology :  Program and the book of abstracts (2015):34,
https://hdl.handle.net/21.15107/rcub_vinar_11402 .

TY  - JOUR
AU  - Bojić, Tijana
AU  - Milovanović, Branislav
AU  - Jovanović-Ćupić, Snežana P.
PY  - 2015
UR  - http://www.archivesofmedicine.com/abstract/genetic-polymorphisms-of-neurocardiovascular-disorders-6481.html
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8409
AB  - The autonomic nervous control of cardiovascular (CV) system plays a major role in the adaptation of the organism to the changes in external and internal environment. It’s dysfunction is the major pathophysiological factor in the development of neurocardiovascular diseases. The aim of this review is to present the state of the art on the role of candidate gene polymorphisms of the molecules in the signaling chain of neurocardiovascular transmission in neurocardiovascular diseases. Neurocardiovascular disorders can be classified as sympathetic vs. vagally mediated disorders, though in many disorders both systems are dysfunctional. A number of molecules along the signaling pathway can be functionally modified and be the background of the predisposition, faster progression or complicated form of the disease. When the disease is the consequence of the joined parasympathetic and sympathetic nervous system disequilibrium, the focus of neurogenetic research should be on molecules providing the cross-talk between the two systems: on intercellular and intracellular level and on the level of the signaling process integration. An aggregation of positive results for the association between certain genes and different neurocardiovascular phenotypes pointed on a specific "neurocardiovascular genetic hotspots". Identification of these genes could be of particular interest as a diagnostic tool in the clustered form of neurocardiovascular diseases. New data obtained from neurogenetic approach will improve the disease outcome by gene, pharmacologic and behavioral modulation of the autonomic nervous system.
T2  - Archives of Medicine
T1  - Genetic Polymorphisms of Neurocardiovascular Disorders
VL  - 7
IS  - 2
UR  - https://hdl.handle.net/21.15107/rcub_vinar_8409
ER  - 

@article{
author = "Bojić, Tijana and Milovanović, Branislav and Jovanović-Ćupić, Snežana P.",
year = "2015",
abstract = "The autonomic nervous control of cardiovascular (CV) system plays a major role in the adaptation of the organism to the changes in external and internal environment. It’s dysfunction is the major pathophysiological factor in the development of neurocardiovascular diseases. The aim of this review is to present the state of the art on the role of candidate gene polymorphisms of the molecules in the signaling chain of neurocardiovascular transmission in neurocardiovascular diseases. Neurocardiovascular disorders can be classified as sympathetic vs. vagally mediated disorders, though in many disorders both systems are dysfunctional. A number of molecules along the signaling pathway can be functionally modified and be the background of the predisposition, faster progression or complicated form of the disease. When the disease is the consequence of the joined parasympathetic and sympathetic nervous system disequilibrium, the focus of neurogenetic research should be on molecules providing the cross-talk between the two systems: on intercellular and intracellular level and on the level of the signaling process integration. An aggregation of positive results for the association between certain genes and different neurocardiovascular phenotypes pointed on a specific "neurocardiovascular genetic hotspots". Identification of these genes could be of particular interest as a diagnostic tool in the clustered form of neurocardiovascular diseases. New data obtained from neurogenetic approach will improve the disease outcome by gene, pharmacologic and behavioral modulation of the autonomic nervous system.",
journal = "Archives of Medicine",
title = "Genetic Polymorphisms of Neurocardiovascular Disorders",
volume = "7",
number = "2",
url = "https://hdl.handle.net/21.15107/rcub_vinar_8409"
}

Bojić, T., Milovanović, B.,& Jovanović-Ćupić, S. P.. (2015). Genetic Polymorphisms of Neurocardiovascular Disorders. in Archives of Medicine, 7(2).
https://hdl.handle.net/21.15107/rcub_vinar_8409

Bojić T, Milovanović B, Jovanović-Ćupić SP. Genetic Polymorphisms of Neurocardiovascular Disorders. in Archives of Medicine. 2015;7(2).
https://hdl.handle.net/21.15107/rcub_vinar_8409 .

Bojić, Tijana, Milovanović, Branislav, Jovanović-Ćupić, Snežana P., "Genetic Polymorphisms of Neurocardiovascular Disorders" in Archives of Medicine, 7, no. 2 (2015),
https://hdl.handle.net/21.15107/rcub_vinar_8409 .

TY  - CONF
AU  - Kolić, Ivana
AU  - Jovanović, Ivan
AU  - Bojić Milinović, Tijana
AU  - Milovanović, Branislav
AU  - Đurić, Tamara
AU  - Alavantić, Dragan
AU  - Stanković, Aleksandra
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12687
PB  - Belgrade : Serbian Neuroscience Society
C3  - NEUROCARD 2014 : 6th International Symposium on Neurocardiology : The 5th International Symposium on Noninvasive Electrocardiology : Book of abstracts
T1  - Renin-angiotensin system gene polymorphisms in association with cardiovascular profiles in patients with vasovagal syncope
SP  - 58
EP  - 58
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12687
ER  - 

@conference{
author = "Kolić, Ivana and Jovanović, Ivan and Bojić Milinović, Tijana and Milovanović, Branislav and Đurić, Tamara and Alavantić, Dragan and Stanković, Aleksandra",
year = "2014",
publisher = "Belgrade : Serbian Neuroscience Society",
journal = "NEUROCARD 2014 : 6th International Symposium on Neurocardiology : The 5th International Symposium on Noninvasive Electrocardiology : Book of abstracts",
title = "Renin-angiotensin system gene polymorphisms in association with cardiovascular profiles in patients with vasovagal syncope",
pages = "58-58",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12687"
}

Kolić, I., Jovanović, I., Bojić Milinović, T., Milovanović, B., Đurić, T., Alavantić, D.,& Stanković, A.. (2014). Renin-angiotensin system gene polymorphisms in association with cardiovascular profiles in patients with vasovagal syncope. in NEUROCARD 2014 : 6th International Symposium on Neurocardiology : The 5th International Symposium on Noninvasive Electrocardiology : Book of abstracts
Belgrade : Serbian Neuroscience Society., 58-58.
https://hdl.handle.net/21.15107/rcub_vinar_12687

Kolić I, Jovanović I, Bojić Milinović T, Milovanović B, Đurić T, Alavantić D, Stanković A. Renin-angiotensin system gene polymorphisms in association with cardiovascular profiles in patients with vasovagal syncope. in NEUROCARD 2014 : 6th International Symposium on Neurocardiology : The 5th International Symposium on Noninvasive Electrocardiology : Book of abstracts. 2014;:58-58.
https://hdl.handle.net/21.15107/rcub_vinar_12687 .

Kolić, Ivana, Jovanović, Ivan, Bojić Milinović, Tijana, Milovanović, Branislav, Đurić, Tamara, Alavantić, Dragan, Stanković, Aleksandra, "Renin-angiotensin system gene polymorphisms in association with cardiovascular profiles in patients with vasovagal syncope" in NEUROCARD 2014 : 6th International Symposium on Neurocardiology : The 5th International Symposium on Noninvasive Electrocardiology : Book of abstracts (2014):58-58,
https://hdl.handle.net/21.15107/rcub_vinar_12687 .

TY  - CONF
AU  - Životić, Ivan
AU  - Kolić, Ivana
AU  - Milovanović, Branislav
AU  - Đurić, Tamara
AU  - Živković, Maja
AU  - Stanković, Aleksandra
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12688
PB  - Belgrade : Serbian Neuroscience Society
C3  - NEUROCARD 2014 : 6th International Symposium on Neurocardiology : The 5th International Symposium on Noninvasive Electrocardiology : Book of abstracts
T1  - The impact of RAS genes and BDKRB2 −58C/T (rs1799722) gene polymorphism on electrocardiographic and heart rate variability in hypertension
SP  - 59
EP  - 59
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12688
ER  - 

@conference{
author = "Životić, Ivan and Kolić, Ivana and Milovanović, Branislav and Đurić, Tamara and Živković, Maja and Stanković, Aleksandra",
year = "2014",
publisher = "Belgrade : Serbian Neuroscience Society",
journal = "NEUROCARD 2014 : 6th International Symposium on Neurocardiology : The 5th International Symposium on Noninvasive Electrocardiology : Book of abstracts",
title = "The impact of RAS genes and BDKRB2 −58C/T (rs1799722) gene polymorphism on electrocardiographic and heart rate variability in hypertension",
pages = "59-59",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12688"
}

Životić, I., Kolić, I., Milovanović, B., Đurić, T., Živković, M.,& Stanković, A.. (2014). The impact of RAS genes and BDKRB2 −58C/T (rs1799722) gene polymorphism on electrocardiographic and heart rate variability in hypertension. in NEUROCARD 2014 : 6th International Symposium on Neurocardiology : The 5th International Symposium on Noninvasive Electrocardiology : Book of abstracts
Belgrade : Serbian Neuroscience Society., 59-59.
https://hdl.handle.net/21.15107/rcub_vinar_12688

Životić I, Kolić I, Milovanović B, Đurić T, Živković M, Stanković A. The impact of RAS genes and BDKRB2 −58C/T (rs1799722) gene polymorphism on electrocardiographic and heart rate variability in hypertension. in NEUROCARD 2014 : 6th International Symposium on Neurocardiology : The 5th International Symposium on Noninvasive Electrocardiology : Book of abstracts. 2014;:59-59.
https://hdl.handle.net/21.15107/rcub_vinar_12688 .

Životić, Ivan, Kolić, Ivana, Milovanović, Branislav, Đurić, Tamara, Živković, Maja, Stanković, Aleksandra, "The impact of RAS genes and BDKRB2 −58C/T (rs1799722) gene polymorphism on electrocardiographic and heart rate variability in hypertension" in NEUROCARD 2014 : 6th International Symposium on Neurocardiology : The 5th International Symposium on Noninvasive Electrocardiology : Book of abstracts (2014):59-59,
https://hdl.handle.net/21.15107/rcub_vinar_12688 .

TY  - CONF
AU  - Stanković, Aleksandra
AU  - Bojić Milinović, Tijana
AU  - Milovanović, Branislav
AU  - Kolić, Ivana
AU  - Jovanović, Ivan
AU  - Alavantić, Dragan
AU  - Živković, Maja
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12685
PB  - Belgrade : Serbian Neuroscience Society
C3  - NEUROCARD 2013 : 5th International Symposium on Neurocardiology : The 4th International Symposium on Noninvasive Electrocardiology : Book of abstracts
T1  - The ATR1 1166A/C and BDKRB2 −58C/T (rs1799722) gene polymorphisms impact on electrocardiographic and heart rate variability in hypertensive Serbian patients. Preliminary study
SP  - 82
EP  - 82
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12685
ER  - 

@conference{
author = "Stanković, Aleksandra and Bojić Milinović, Tijana and Milovanović, Branislav and Kolić, Ivana and Jovanović, Ivan and Alavantić, Dragan and Živković, Maja",
year = "2013",
publisher = "Belgrade : Serbian Neuroscience Society",
journal = "NEUROCARD 2013 : 5th International Symposium on Neurocardiology : The 4th International Symposium on Noninvasive Electrocardiology : Book of abstracts",
title = "The ATR1 1166A/C and BDKRB2 −58C/T (rs1799722) gene polymorphisms impact on electrocardiographic and heart rate variability in hypertensive Serbian patients. Preliminary study",
pages = "82-82",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12685"
}

Stanković, A., Bojić Milinović, T., Milovanović, B., Kolić, I., Jovanović, I., Alavantić, D.,& Živković, M.. (2013). The ATR1 1166A/C and BDKRB2 −58C/T (rs1799722) gene polymorphisms impact on electrocardiographic and heart rate variability in hypertensive Serbian patients. Preliminary study. in NEUROCARD 2013 : 5th International Symposium on Neurocardiology : The 4th International Symposium on Noninvasive Electrocardiology : Book of abstracts
Belgrade : Serbian Neuroscience Society., 82-82.
https://hdl.handle.net/21.15107/rcub_vinar_12685

Stanković A, Bojić Milinović T, Milovanović B, Kolić I, Jovanović I, Alavantić D, Živković M. The ATR1 1166A/C and BDKRB2 −58C/T (rs1799722) gene polymorphisms impact on electrocardiographic and heart rate variability in hypertensive Serbian patients. Preliminary study. in NEUROCARD 2013 : 5th International Symposium on Neurocardiology : The 4th International Symposium on Noninvasive Electrocardiology : Book of abstracts. 2013;:82-82.
https://hdl.handle.net/21.15107/rcub_vinar_12685 .

Stanković, Aleksandra, Bojić Milinović, Tijana, Milovanović, Branislav, Kolić, Ivana, Jovanović, Ivan, Alavantić, Dragan, Živković, Maja, "The ATR1 1166A/C and BDKRB2 −58C/T (rs1799722) gene polymorphisms impact on electrocardiographic and heart rate variability in hypertensive Serbian patients. Preliminary study" in NEUROCARD 2013 : 5th International Symposium on Neurocardiology : The 4th International Symposium on Noninvasive Electrocardiology : Book of abstracts (2013):82-82,
https://hdl.handle.net/21.15107/rcub_vinar_12685 .

TY  - CONF
AU  - Milovanović, Branislav
AU  - Bojić, Tijana
AU  - Kolaković, Ana
AU  - Alavantić, Dragan
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12698
AB  - INTRODUCTION: Polymorphisms of renin-angiotensin system (RAS) in hypertensive patients may be associated with
ECG parameters (QT, QRS complex, QRS axis, pNN50, rms SD). QT interval prolongation on 12-lead ECG is a predictor
of sudden cardiac death due to ventricular arrhythmias (1). Hypertension is the state where RAS activity is modulated,
and this can remodel the cardiac ion channels, resulting in prolongation (QT interval) and redirection of ventricular
depolarization (QRS axis) and repolarization. Cardiac ion channels can be affected by such factors as the strech of the
myocites by high blood pressure (2). To our knowledge no investigation has been done on the association of RAS
genetic polymorphisms with the ECG parameters QT interval, QRS axis and time domain indexes of heart rate variability
pNN50 and rmsSD. AIM. The aim of the study was to investigate the association of RAS genetic polymorphisms (ACE
I/D, ATR1 1166 A/C, ATR2 1332 A/G) with ECG parameters (QT, QRS axis, pNN50 and rmsSD).
METHODS. The study was conducted on 36 Serbian hypertensive untreated patients (age (mean±SD)=51.6±9.9
years, 17 female and 19 male) who were ECG monitored (Schiller multiparameter monitor) and taken whole blood
sample for genetic analysis. DNA was extracted on the basis of phenol-chlorophorm method while genotypisation was
done by PCR-restriction fragment lenght polymorphism method (3,4). Statistical analysis was performed using
statistical package of SPSS program (SPSS 17.0).
RESULTS. The results are summarized in Table 1. CONCLUSIONS: Our data are in line with the data in the literature that ACE D allele carriers intensify left ventricular
hypertrophy, myocardial fibrosis and hypertension (5, 6). These changes contribute to electrophysiologic remodeling of
myocardium resulting in change of parameters like QT interval and QRS axis. Parameters of short term heart rate
variability showed tendency to be associated to RAS polymorphisms. Further investigations are needed to bring us
definite conclusions.
PB  - Belgrade : Serbian neurocardiological society
C3  - NEUROCARD 2012 : 4th International Symposium on Neurocardiology : 3rd International Symposium on Noninvasive Electrocardiology : Program and the book of abstracts
T1  - The associations of genetic polymorphisms of reninangiotensin system with ECG - parameters of short-term analysis (Schiller multiparameter monitor): the preliminary study
SP  - 142
EP  - 142
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12698
ER  - 

@conference{
author = "Milovanović, Branislav and Bojić, Tijana and Kolaković, Ana and Alavantić, Dragan",
year = "2012",
abstract = "INTRODUCTION: Polymorphisms of renin-angiotensin system (RAS) in hypertensive patients may be associated with
ECG parameters (QT, QRS complex, QRS axis, pNN50, rms SD). QT interval prolongation on 12-lead ECG is a predictor
of sudden cardiac death due to ventricular arrhythmias (1). Hypertension is the state where RAS activity is modulated,
and this can remodel the cardiac ion channels, resulting in prolongation (QT interval) and redirection of ventricular
depolarization (QRS axis) and repolarization. Cardiac ion channels can be affected by such factors as the strech of the
myocites by high blood pressure (2). To our knowledge no investigation has been done on the association of RAS
genetic polymorphisms with the ECG parameters QT interval, QRS axis and time domain indexes of heart rate variability
pNN50 and rmsSD. AIM. The aim of the study was to investigate the association of RAS genetic polymorphisms (ACE
I/D, ATR1 1166 A/C, ATR2 1332 A/G) with ECG parameters (QT, QRS axis, pNN50 and rmsSD).
METHODS. The study was conducted on 36 Serbian hypertensive untreated patients (age (mean±SD)=51.6±9.9
years, 17 female and 19 male) who were ECG monitored (Schiller multiparameter monitor) and taken whole blood
sample for genetic analysis. DNA was extracted on the basis of phenol-chlorophorm method while genotypisation was
done by PCR-restriction fragment lenght polymorphism method (3,4). Statistical analysis was performed using
statistical package of SPSS program (SPSS 17.0).
RESULTS. The results are summarized in Table 1. CONCLUSIONS: Our data are in line with the data in the literature that ACE D allele carriers intensify left ventricular
hypertrophy, myocardial fibrosis and hypertension (5, 6). These changes contribute to electrophysiologic remodeling of
myocardium resulting in change of parameters like QT interval and QRS axis. Parameters of short term heart rate
variability showed tendency to be associated to RAS polymorphisms. Further investigations are needed to bring us
definite conclusions.",
publisher = "Belgrade : Serbian neurocardiological society",
journal = "NEUROCARD 2012 : 4th International Symposium on Neurocardiology : 3rd International Symposium on Noninvasive Electrocardiology : Program and the book of abstracts",
title = "The associations of genetic polymorphisms of reninangiotensin system with ECG - parameters of short-term analysis (Schiller multiparameter monitor): the preliminary study",
pages = "142-142",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12698"
}

Milovanović, B., Bojić, T., Kolaković, A.,& Alavantić, D.. (2012). The associations of genetic polymorphisms of reninangiotensin system with ECG - parameters of short-term analysis (Schiller multiparameter monitor): the preliminary study. in NEUROCARD 2012 : 4th International Symposium on Neurocardiology : 3rd International Symposium on Noninvasive Electrocardiology : Program and the book of abstracts
Belgrade : Serbian neurocardiological society., 142-142.
https://hdl.handle.net/21.15107/rcub_vinar_12698

Milovanović B, Bojić T, Kolaković A, Alavantić D. The associations of genetic polymorphisms of reninangiotensin system with ECG - parameters of short-term analysis (Schiller multiparameter monitor): the preliminary study. in NEUROCARD 2012 : 4th International Symposium on Neurocardiology : 3rd International Symposium on Noninvasive Electrocardiology : Program and the book of abstracts. 2012;:142-142.
https://hdl.handle.net/21.15107/rcub_vinar_12698 .

Milovanović, Branislav, Bojić, Tijana, Kolaković, Ana, Alavantić, Dragan, "The associations of genetic polymorphisms of reninangiotensin system with ECG - parameters of short-term analysis (Schiller multiparameter monitor): the preliminary study" in NEUROCARD 2012 : 4th International Symposium on Neurocardiology : 3rd International Symposium on Noninvasive Electrocardiology : Program and the book of abstracts (2012):142-142,
https://hdl.handle.net/21.15107/rcub_vinar_12698 .

TY  - JOUR
AU  - Keković, Goran
AU  - Milovanović, Branislav
AU  - Davidović, Dragomir
AU  - Raković, Dejan
AU  - Culic, Milka
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5428
AB  - Objective: We investigated the effects of bisoprolol and losartan on subjects with essential hypertension, by conducting heart rate variability (HRV) analysis of ECG signals. Our intention was to establish the set of linear and nonlinear heart rate variability parameters, which could be used as a noninvasive markers in the treatment of hypertension. Materials and Methods: Sixty subjects with essential hypertension included in this study were divided in two groups. During the four weeks medical treatment, the first group was administered with daily oral dose of 5 mg of bisoprolol and the second with daily oral dose of 50 mg of losartan. We recorded ECG signals, and performed HRV analysis of consecutive RR time intervals, before and after a month of pharmacological therapy. Results: In the case of bisoprolol, statistically the most significant changes of HRV parameters were: TP (1814.1 +/- 1731.3 ms(2) vs. 761.3 +/- 725.0 ms(2), P LT 0.0001), RR (870.2 +/- 105.7 ms vs. 1027.2 +/- 150.0 ms, P LT 0.0001), HR (70.81 +/- 8.42 bp/min vs. 60.10 +/- 9.52 bp/min, P LT 0.0001). In the case of losartan, the most significant changes were: SDNN (43.16 +/- 17.27 ms vs. 237.98 +/- 118.54 ms, P = 0.002), rmSDD (27.09 +/- 18.27 ms vs. 46.82 +/- 37.71 ms, P = 0.003), SD2 (55.18 +/- 20.6 vs. 70.67 +/- 26.12, P LT 0.019) and DF2 (0.69 +/- 0.21 vs. 0.86 +/- 0.25, P LT 0.014). Conclusion: Effects of bisoprolol and losartan were especially manifested among the set of linear HRV parameters. As a consequence of effect of losartan, we singled out the nonlinear parameters SD2 and DF2.
T2  - Journal of Research in Medical Sciences
T1  - Comparative effect of bisoprolol and losartan in the treatment of essential hypertension
VL  - 17
IS  - 11
SP  - 1027
EP  - 1032
UR  - https://hdl.handle.net/21.15107/rcub_vinar_5428
ER  - 

@article{
author = "Keković, Goran and Milovanović, Branislav and Davidović, Dragomir and Raković, Dejan and Culic, Milka",
year = "2012",
abstract = "Objective: We investigated the effects of bisoprolol and losartan on subjects with essential hypertension, by conducting heart rate variability (HRV) analysis of ECG signals. Our intention was to establish the set of linear and nonlinear heart rate variability parameters, which could be used as a noninvasive markers in the treatment of hypertension. Materials and Methods: Sixty subjects with essential hypertension included in this study were divided in two groups. During the four weeks medical treatment, the first group was administered with daily oral dose of 5 mg of bisoprolol and the second with daily oral dose of 50 mg of losartan. We recorded ECG signals, and performed HRV analysis of consecutive RR time intervals, before and after a month of pharmacological therapy. Results: In the case of bisoprolol, statistically the most significant changes of HRV parameters were: TP (1814.1 +/- 1731.3 ms(2) vs. 761.3 +/- 725.0 ms(2), P LT 0.0001), RR (870.2 +/- 105.7 ms vs. 1027.2 +/- 150.0 ms, P LT 0.0001), HR (70.81 +/- 8.42 bp/min vs. 60.10 +/- 9.52 bp/min, P LT 0.0001). In the case of losartan, the most significant changes were: SDNN (43.16 +/- 17.27 ms vs. 237.98 +/- 118.54 ms, P = 0.002), rmSDD (27.09 +/- 18.27 ms vs. 46.82 +/- 37.71 ms, P = 0.003), SD2 (55.18 +/- 20.6 vs. 70.67 +/- 26.12, P LT 0.019) and DF2 (0.69 +/- 0.21 vs. 0.86 +/- 0.25, P LT 0.014). Conclusion: Effects of bisoprolol and losartan were especially manifested among the set of linear HRV parameters. As a consequence of effect of losartan, we singled out the nonlinear parameters SD2 and DF2.",
journal = "Journal of Research in Medical Sciences",
title = "Comparative effect of bisoprolol and losartan in the treatment of essential hypertension",
volume = "17",
number = "11",
pages = "1027-1032",
url = "https://hdl.handle.net/21.15107/rcub_vinar_5428"
}

Keković, G., Milovanović, B., Davidović, D., Raković, D.,& Culic, M.. (2012). Comparative effect of bisoprolol and losartan in the treatment of essential hypertension. in Journal of Research in Medical Sciences, 17(11), 1027-1032.
https://hdl.handle.net/21.15107/rcub_vinar_5428

Keković G, Milovanović B, Davidović D, Raković D, Culic M. Comparative effect of bisoprolol and losartan in the treatment of essential hypertension. in Journal of Research in Medical Sciences. 2012;17(11):1027-1032.
https://hdl.handle.net/21.15107/rcub_vinar_5428 .

Keković, Goran, Milovanović, Branislav, Davidović, Dragomir, Raković, Dejan, Culic, Milka, "Comparative effect of bisoprolol and losartan in the treatment of essential hypertension" in Journal of Research in Medical Sciences, 17, no. 11 (2012):1027-1032,
https://hdl.handle.net/21.15107/rcub_vinar_5428 .

TY  - JOUR
AU  - Bjelaković, Bojko
AU  - Ilić, Stevan
AU  - Chouliaras, Konstantinos
AU  - Milovanović, Branislav
AU  - Vukomanović, Vladislav
AU  - Bojić, Tijana
AU  - Bjelaković, Ljiljana
AU  - Zaharov, Tatjana
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8868
AB  - Ventricular arrhythmias (VAs) are common pediatric rhythm disorders requiring comprehensive laboratory evaluation. Although usually idiopathic, implying a benign character and favorable prognosis, the initial clinical approach is still not established in all cases. Considering their prognostic significance, exercise-induced (precipitated or aggravated) VAs usually require additional diagnostics, treatment, and follow-up. A number of reports have presented experimental and clinical evidence that increased sympathetic activity can initiate, or at least facilitate, VAs. Recent data highlight the relationship between exercise-induced idiopathic VAs (IVAs) and the long-term risk of cardiovascular death. The aim of this study was to assess the utility of heart rate variability (HRV) analysis as a noninvasive method for estimating autonomic nervous activity in children with exerciseinduced IVAs. The study included 42 children with IVAs, who were divided into two groups: children with exerciseinduced (precipitated or aggravated) IVAs and children with exercised-suppressed IVAs. Time-domain HRV parameters were analyzed from 24-h ambulatory electrocardiography recordings, and the majority of children underwent an exercise stress test using the McMaster protocol. The results of this study showed no significant changes in parasympathetic index, i.e., the square root of the mean of the sum of the squares of the differences between adjacent NN intervals (the length between two successive heartbeats) between the groups examined. On the other hand, we observed diminished time-domain values for the standard deviation of all adjacent NN intervals, as well as diminished time-domain values for standard deviation of the averages of NN intervals in all 5-min segments in the group of children with exercise-induced IVAs, implicating increased sympathetic activity in such individuals. HRV analysis could be a helpful diagnostic method, giving useful information regarding cardiac autonomic control in some children with exercise-induced IVAs. © Springer Science+Business Media, LLC 2009.
T2  - Pediatric Cardiology
T1  - Heart Rate Variability in Children with Exercise-Induced Idiopathic Ventricular Arrhythmias
VL  - 31
IS  - 2
SP  - 188
EP  - 194
DO  - 10.1007/s00246-009-9582-3
ER  - 

@article{
author = "Bjelaković, Bojko and Ilić, Stevan and Chouliaras, Konstantinos and Milovanović, Branislav and Vukomanović, Vladislav and Bojić, Tijana and Bjelaković, Ljiljana and Zaharov, Tatjana",
year = "2010",
abstract = "Ventricular arrhythmias (VAs) are common pediatric rhythm disorders requiring comprehensive laboratory evaluation. Although usually idiopathic, implying a benign character and favorable prognosis, the initial clinical approach is still not established in all cases. Considering their prognostic significance, exercise-induced (precipitated or aggravated) VAs usually require additional diagnostics, treatment, and follow-up. A number of reports have presented experimental and clinical evidence that increased sympathetic activity can initiate, or at least facilitate, VAs. Recent data highlight the relationship between exercise-induced idiopathic VAs (IVAs) and the long-term risk of cardiovascular death. The aim of this study was to assess the utility of heart rate variability (HRV) analysis as a noninvasive method for estimating autonomic nervous activity in children with exerciseinduced IVAs. The study included 42 children with IVAs, who were divided into two groups: children with exerciseinduced (precipitated or aggravated) IVAs and children with exercised-suppressed IVAs. Time-domain HRV parameters were analyzed from 24-h ambulatory electrocardiography recordings, and the majority of children underwent an exercise stress test using the McMaster protocol. The results of this study showed no significant changes in parasympathetic index, i.e., the square root of the mean of the sum of the squares of the differences between adjacent NN intervals (the length between two successive heartbeats) between the groups examined. On the other hand, we observed diminished time-domain values for the standard deviation of all adjacent NN intervals, as well as diminished time-domain values for standard deviation of the averages of NN intervals in all 5-min segments in the group of children with exercise-induced IVAs, implicating increased sympathetic activity in such individuals. HRV analysis could be a helpful diagnostic method, giving useful information regarding cardiac autonomic control in some children with exercise-induced IVAs. © Springer Science+Business Media, LLC 2009.",
journal = "Pediatric Cardiology",
title = "Heart Rate Variability in Children with Exercise-Induced Idiopathic Ventricular Arrhythmias",
volume = "31",
number = "2",
pages = "188-194",
doi = "10.1007/s00246-009-9582-3"
}

Bjelaković, B., Ilić, S., Chouliaras, K., Milovanović, B., Vukomanović, V., Bojić, T., Bjelaković, L.,& Zaharov, T.. (2010). Heart Rate Variability in Children with Exercise-Induced Idiopathic Ventricular Arrhythmias. in Pediatric Cardiology, 31(2), 188-194.
https://doi.org/10.1007/s00246-009-9582-3

Bjelaković B, Ilić S, Chouliaras K, Milovanović B, Vukomanović V, Bojić T, Bjelaković L, Zaharov T. Heart Rate Variability in Children with Exercise-Induced Idiopathic Ventricular Arrhythmias. in Pediatric Cardiology. 2010;31(2):188-194.
doi:10.1007/s00246-009-9582-3 .

Bjelaković, Bojko, Ilić, Stevan, Chouliaras, Konstantinos, Milovanović, Branislav, Vukomanović, Vladislav, Bojić, Tijana, Bjelaković, Ljiljana, Zaharov, Tatjana, "Heart Rate Variability in Children with Exercise-Induced Idiopathic Ventricular Arrhythmias" in Pediatric Cardiology, 31, no. 2 (2010):188-194,
https://doi.org/10.1007/s00246-009-9582-3 . .