TY  - JOUR
AU  - Đorđević, Ana
AU  - Živković, Maja
AU  - Bošković, Maja
AU  - Dekleva, Milica
AU  - Stanković, Goran
AU  - Stanković, Aleksandra
AU  - Đurić, Tamara
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10617
AB  - Galectin-3 is encoded by LGALS-3, located in a unique haplotype block in Caucasians. According to the Tagger server, rs4040064, rs11628437, and rs7159490 cover 82% (r2 > 0.8) of the genetic variance of this HapBlock. Our aims were to examine the association of their haplotypes with first myocardial infarction (MI), changes in left ventricular echocardiographic parameters over time, and impact on plasma galectin-3 and LGALS-3 mRNA in peripheral blood mononuclear cells, both 6 months post-MI. The study group consisted of 546 MI patients and 323 controls. Gene expression was assessed in 92 patients and plasma galectin-3 in 189 patients. Rs4040064, rs11628437, rs7159490, and LGALS-3 mRNA expression were detected using TaqMan® technology. Plasma galectin-3 concentrations were determined by the ELISA method. We found that the TGC haplotype could have a protective effect against MI (adjusted OR 0.19 [0.05–0.72], p = 0.015) and that the GAC haplotype had significantly higher galectin-3 concentrations (48.3 [37.3–59.4] ng/mL vs. 18.9 [14.5–23.4] ng/mL, p < 0.0001), both in males and compared to the referent haplotype GGC. Higher plasma Gal-3 was also associated with higher NYHA class and systolic dysfunction. Our results suggest that variants tagging LGALS-3 HapBlock could reflect plasma Gal-3 levels 6 months post-MI and may have a potential protective effect against MI in men. Further replication, validation, and functional studies are needed.
T2  - Genes
T1  - Variants Tagging LGALS-3 Haplotype Block in Association with First Myocardial Infarction and Plasma Galectin-3 Six Months after the Acute Event
VL  - 14
IS  - 1
SP  - 109
DO  - 10.3390/genes14010109
ER  - 

@article{
author = "Đorđević, Ana and Živković, Maja and Bošković, Maja and Dekleva, Milica and Stanković, Goran and Stanković, Aleksandra and Đurić, Tamara",
year = "2023",
abstract = "Galectin-3 is encoded by LGALS-3, located in a unique haplotype block in Caucasians. According to the Tagger server, rs4040064, rs11628437, and rs7159490 cover 82% (r2 > 0.8) of the genetic variance of this HapBlock. Our aims were to examine the association of their haplotypes with first myocardial infarction (MI), changes in left ventricular echocardiographic parameters over time, and impact on plasma galectin-3 and LGALS-3 mRNA in peripheral blood mononuclear cells, both 6 months post-MI. The study group consisted of 546 MI patients and 323 controls. Gene expression was assessed in 92 patients and plasma galectin-3 in 189 patients. Rs4040064, rs11628437, rs7159490, and LGALS-3 mRNA expression were detected using TaqMan® technology. Plasma galectin-3 concentrations were determined by the ELISA method. We found that the TGC haplotype could have a protective effect against MI (adjusted OR 0.19 [0.05–0.72], p = 0.015) and that the GAC haplotype had significantly higher galectin-3 concentrations (48.3 [37.3–59.4] ng/mL vs. 18.9 [14.5–23.4] ng/mL, p < 0.0001), both in males and compared to the referent haplotype GGC. Higher plasma Gal-3 was also associated with higher NYHA class and systolic dysfunction. Our results suggest that variants tagging LGALS-3 HapBlock could reflect plasma Gal-3 levels 6 months post-MI and may have a potential protective effect against MI in men. Further replication, validation, and functional studies are needed.",
journal = "Genes",
title = "Variants Tagging LGALS-3 Haplotype Block in Association with First Myocardial Infarction and Plasma Galectin-3 Six Months after the Acute Event",
volume = "14",
number = "1",
pages = "109",
doi = "10.3390/genes14010109"
}

Đorđević, A., Živković, M., Bošković, M., Dekleva, M., Stanković, G., Stanković, A.,& Đurić, T.. (2023). Variants Tagging LGALS-3 Haplotype Block in Association with First Myocardial Infarction and Plasma Galectin-3 Six Months after the Acute Event. in Genes, 14(1), 109.
https://doi.org/10.3390/genes14010109

Đorđević A, Živković M, Bošković M, Dekleva M, Stanković G, Stanković A, Đurić T. Variants Tagging LGALS-3 Haplotype Block in Association with First Myocardial Infarction and Plasma Galectin-3 Six Months after the Acute Event. in Genes. 2023;14(1):109.
doi:10.3390/genes14010109 .

Đorđević, Ana, Živković, Maja, Bošković, Maja, Dekleva, Milica, Stanković, Goran, Stanković, Aleksandra, Đurić, Tamara, "Variants Tagging LGALS-3 Haplotype Block in Association with First Myocardial Infarction and Plasma Galectin-3 Six Months after the Acute Event" in Genes, 14, no. 1 (2023):109,
https://doi.org/10.3390/genes14010109 . .

TY  - CONF
AU  - Stanković, Aleksandra
AU  - Jovanović, Ivan G.
AU  - Dinčić, E.
AU  - Vojinović, S.
AU  - Stojković, Ljiljana S.
AU  - Đorđević, Ana
AU  - Kuveljić, Jovana
AU  - Živković, Maja
PY  - 2023
UR  - https://web.archive.org/web/20240131090652/https://cony2023.comtecmed.com/e-posters/
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12641
AB  - Molecular background and biomarkers of highly heterogenous and hardly predictable disease progression among relapse-onset MS patients are of high research interest. In the current pilot study, we aimed to employ next-generation sequencing to investigate the expression of whole small non-coding microRNAs (miRNome) in two groups of MS patients with highly distinctive progression phenotype: one with fast progressing, severely disabling course vs. mild course of MS, longitudinally followed 10 years. Peripheral blood mononuclear cells (PBMC) miRNome data was obtained from mild phenotype MS (n=4 patients) and progressive phenotype MS (n=5 patients), using TakaraBio SMARTer smRNA-Seq Kit on iSeq100 (Illumina). Pre-processing of raw sequencing data, quality control and miRNA differential expression analysis was performed using sRNAtoolbox pipeline. Functional interpretation of differentially expressed miRNA target genes was done in DIANA-miRPathv3.0. Tarbase v8.0 served as a resource of miRNA:gene interactions. Achieved read depth was approximately 1 million raw reads/sample, allowing detection of up to 92 mature miRNAs after genome alignment and miRbase v22 annotation. Differential expression analysis identified the significant upregulation of hsa-miR-23c (log2FC=4.29, Padj= 0.03) in progressive phenotype. Top significantly enriched KEGG pathways in hsa-miR-23c targets suggested regulation of molecular pathways involved in autoimmunity (antigen presentation, Epstein-Barr virus infection) and cancer. In conclusion, this pilot study indicates phenotype-related differences in expression of miRNAs, molecules with high regulatory and biomarker properties. Although detected in PBMC, has-miR-23c is highly expressed in the brain and target MS relevant genes such as, HLA (A, B, C), transferrin receptor, Nrf2, recently proposed to play important role in neurodegeneration.
C3  - 17th World Congress on Controversies in Neurology (CONy) : e-posters
T1  - Insight in miRNome of severe multiple sclerosis: Pilot study of distinctive relapse-onset MS phenotypes
SP  - 427
EP  - 427
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12641
ER  - 

@conference{
author = "Stanković, Aleksandra and Jovanović, Ivan G. and Dinčić, E. and Vojinović, S. and Stojković, Ljiljana S. and Đorđević, Ana and Kuveljić, Jovana and Živković, Maja",
year = "2023",
abstract = "Molecular background and biomarkers of highly heterogenous and hardly predictable disease progression among relapse-onset MS patients are of high research interest. In the current pilot study, we aimed to employ next-generation sequencing to investigate the expression of whole small non-coding microRNAs (miRNome) in two groups of MS patients with highly distinctive progression phenotype: one with fast progressing, severely disabling course vs. mild course of MS, longitudinally followed 10 years. Peripheral blood mononuclear cells (PBMC) miRNome data was obtained from mild phenotype MS (n=4 patients) and progressive phenotype MS (n=5 patients), using TakaraBio SMARTer smRNA-Seq Kit on iSeq100 (Illumina). Pre-processing of raw sequencing data, quality control and miRNA differential expression analysis was performed using sRNAtoolbox pipeline. Functional interpretation of differentially expressed miRNA target genes was done in DIANA-miRPathv3.0. Tarbase v8.0 served as a resource of miRNA:gene interactions. Achieved read depth was approximately 1 million raw reads/sample, allowing detection of up to 92 mature miRNAs after genome alignment and miRbase v22 annotation. Differential expression analysis identified the significant upregulation of hsa-miR-23c (log2FC=4.29, Padj= 0.03) in progressive phenotype. Top significantly enriched KEGG pathways in hsa-miR-23c targets suggested regulation of molecular pathways involved in autoimmunity (antigen presentation, Epstein-Barr virus infection) and cancer. In conclusion, this pilot study indicates phenotype-related differences in expression of miRNAs, molecules with high regulatory and biomarker properties. Although detected in PBMC, has-miR-23c is highly expressed in the brain and target MS relevant genes such as, HLA (A, B, C), transferrin receptor, Nrf2, recently proposed to play important role in neurodegeneration.",
journal = "17th World Congress on Controversies in Neurology (CONy) : e-posters",
title = "Insight in miRNome of severe multiple sclerosis: Pilot study of distinctive relapse-onset MS phenotypes",
pages = "427-427",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12641"
}

Stanković, A., Jovanović, I. G., Dinčić, E., Vojinović, S., Stojković, L. S., Đorđević, A., Kuveljić, J.,& Živković, M.. (2023). Insight in miRNome of severe multiple sclerosis: Pilot study of distinctive relapse-onset MS phenotypes. in 17th World Congress on Controversies in Neurology (CONy) : e-posters, 427-427.
https://hdl.handle.net/21.15107/rcub_vinar_12641

Stanković A, Jovanović IG, Dinčić E, Vojinović S, Stojković LS, Đorđević A, Kuveljić J, Živković M. Insight in miRNome of severe multiple sclerosis: Pilot study of distinctive relapse-onset MS phenotypes. in 17th World Congress on Controversies in Neurology (CONy) : e-posters. 2023;:427-427.
https://hdl.handle.net/21.15107/rcub_vinar_12641 .

Stanković, Aleksandra, Jovanović, Ivan G., Dinčić, E., Vojinović, S., Stojković, Ljiljana S., Đorđević, Ana, Kuveljić, Jovana, Živković, Maja, "Insight in miRNome of severe multiple sclerosis: Pilot study of distinctive relapse-onset MS phenotypes" in 17th World Congress on Controversies in Neurology (CONy) : e-posters (2023):427-427,
https://hdl.handle.net/21.15107/rcub_vinar_12641 .

TY  - CONF
AU  - Dekleva, Milica
AU  - Martinović, M.
AU  - Stevanović, Angelina
AU  - Živković, Maja
AU  - Đorđević, Ana
AU  - Đurić, Tamara
AU  - Stanković, Aleksandra
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12854
AB  - Background: Right ventricular (RV) dysfunction is recognized as a cardinal prognostic marker in heart failure (HF) patients. Myocardial infarction (MI) is often followed by unrecognized RV dysfunction, which can be associated with worse outcome. It is recently shown that the ratio between TAPSE and PASP (RV/PA) may depict cardiopulmonary hemodynamics better than the two parameters alone. Aim: To evaluate the interactions between left ventricular (LV) and RV function in early phase of MI and to assess the prognostic significance of RV/PA coupling in patients with first MI during 5 years follow up. Methods: The prospective study included 144 patients with the first MI treated with the primary percutaneous coronary intervention (p PCI) who underwent Doppler echocardiography within 2±1 days of MI. LV function analysis included: LV ejection fraction (EF), ratio between early diastolic velocity and tissue annular velocity (E/e) and global longitudinal strain (GLS). RV function and RV-PA interaction was expressed as ratio between TAPSE and PASP. During the five-year follow-up, major cardiovascular events and especially hospitalization for HF were analyzed. Results: Progressive RV/PA uncoupling was associated with higher degree of LV impairment and dysfunction (EF p<0.001, E/e p=0.002, GLS p<0.001) and severity of mitral regurgitation (p=0.013). Lower baseline RV/PA coupling significantly reflects the frequency of hospitalizations for HF in the population of patients with first MI during five-year follow-up (0.62 v.s.0.51, p=0.021). After multivariate adjustment RV/PA remained an independent predictor of all major cardiac events (MACE) after five years (OR 14.0 [1.5–130.8], p=0.019). Conclusion: A lower baseline RV-PA coupling, reflecting a higher degree of LV-induced pulmonary hypertension and secondary RV-dysfunction, is associated with decline of LV function in early phase of MI, and is independently associated with worse prognosis after five years. The value of RV-PA ratio as an prognstic marker warrants further investigation.
C3  - European Heart Journal
T1  - Right ventricular-pulmonary artery coupling in the early stages of infarction could optimize patient risk stratification over five years
VL  - 44
IS  - Supplement 2
SP  - ehad655.067
DO  - 10.1093/eurheartj/ehad655.067
ER  - 

@conference{
author = "Dekleva, Milica and Martinović, M. and Stevanović, Angelina and Živković, Maja and Đorđević, Ana and Đurić, Tamara and Stanković, Aleksandra",
year = "2023",
abstract = "Background: Right ventricular (RV) dysfunction is recognized as a cardinal prognostic marker in heart failure (HF) patients. Myocardial infarction (MI) is often followed by unrecognized RV dysfunction, which can be associated with worse outcome. It is recently shown that the ratio between TAPSE and PASP (RV/PA) may depict cardiopulmonary hemodynamics better than the two parameters alone. Aim: To evaluate the interactions between left ventricular (LV) and RV function in early phase of MI and to assess the prognostic significance of RV/PA coupling in patients with first MI during 5 years follow up. Methods: The prospective study included 144 patients with the first MI treated with the primary percutaneous coronary intervention (p PCI) who underwent Doppler echocardiography within 2±1 days of MI. LV function analysis included: LV ejection fraction (EF), ratio between early diastolic velocity and tissue annular velocity (E/e) and global longitudinal strain (GLS). RV function and RV-PA interaction was expressed as ratio between TAPSE and PASP. During the five-year follow-up, major cardiovascular events and especially hospitalization for HF were analyzed. Results: Progressive RV/PA uncoupling was associated with higher degree of LV impairment and dysfunction (EF p<0.001, E/e p=0.002, GLS p<0.001) and severity of mitral regurgitation (p=0.013). Lower baseline RV/PA coupling significantly reflects the frequency of hospitalizations for HF in the population of patients with first MI during five-year follow-up (0.62 v.s.0.51, p=0.021). After multivariate adjustment RV/PA remained an independent predictor of all major cardiac events (MACE) after five years (OR 14.0 [1.5–130.8], p=0.019). Conclusion: A lower baseline RV-PA coupling, reflecting a higher degree of LV-induced pulmonary hypertension and secondary RV-dysfunction, is associated with decline of LV function in early phase of MI, and is independently associated with worse prognosis after five years. The value of RV-PA ratio as an prognstic marker warrants further investigation.",
journal = "European Heart Journal",
title = "Right ventricular-pulmonary artery coupling in the early stages of infarction could optimize patient risk stratification over five years",
volume = "44",
number = "Supplement 2",
pages = "ehad655.067",
doi = "10.1093/eurheartj/ehad655.067"
}

Dekleva, M., Martinović, M., Stevanović, A., Živković, M., Đorđević, A., Đurić, T.,& Stanković, A.. (2023). Right ventricular-pulmonary artery coupling in the early stages of infarction could optimize patient risk stratification over five years. in European Heart Journal, 44(Supplement 2), ehad655.067.
https://doi.org/10.1093/eurheartj/ehad655.067

Dekleva M, Martinović M, Stevanović A, Živković M, Đorđević A, Đurić T, Stanković A. Right ventricular-pulmonary artery coupling in the early stages of infarction could optimize patient risk stratification over five years. in European Heart Journal. 2023;44(Supplement 2):ehad655.067.
doi:10.1093/eurheartj/ehad655.067 .

Dekleva, Milica, Martinović, M., Stevanović, Angelina, Živković, Maja, Đorđević, Ana, Đurić, Tamara, Stanković, Aleksandra, "Right ventricular-pulmonary artery coupling in the early stages of infarction could optimize patient risk stratification over five years" in European Heart Journal, 44, no. Supplement 2 (2023):ehad655.067,
https://doi.org/10.1093/eurheartj/ehad655.067 . .

TY  - JOUR
AU  - Đorđević, Ana D.
AU  - Živković, Maja
AU  - Končar, Igor
AU  - Stanković, Aleksandra
AU  - Kuveljić, Jovana
AU  - Đurić, Tamara
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10046
AB  - ObjectivesGalectin-3 affects a variety of biological processes. It is encoded by LGALS-3, located in unique haplotype block in Caucasians. Most of the studies regarding the gal-3 role in atherosclerosis are focused exclusively on protein/mRNA levels. Genetic analyses of LGALS-3 are scarce. We sought to thoroughly examine the genetic background of gal-3 and to analyze tag variants that cover more than 80% variability of the LGALS-3 containing hap-block in association with carotid plaque presence (CPP). According to Tagger server, rs4040064 G/T, rs11628437 G/A and rs7159490 C/T cover 82% (r2 > 0.8) of the genetic variance of this hap-block. Our aims were to investigate possible association of rs4040064, rs11628437 and rs7159490 haplotypes with CPP in patients with advanced carotid atherosclerosis (CA) and to analyze their possible effect on LGALS-3 mRNA expression in carotid plaques.Materials and methodsStudy group consisted of 468 patients and 296 controls. Rs4040064, rs11628437, rs7159490 and LGALS-3 mRNA expression were detected by TaqMan® technology.ResultsWe have found that haplotype TAC was associated with the cerebrovascular insult (CVI) occurrence (OR = 1.68, 95% CI = 1.09-2.58, p = 0.02), compared to the referent haplotype. OR was adjusted for hypertension, age and BMI. TAC also showed higher, but not statistically significant, LGALS-3 expression in carotid plaques.ConclusionsOur results suggest that rs4040064, rs11628437 and rs7159490 bear no association with CPP, neither they affect LGALS-3 mRNA in carotid plaques. However, we showed a significant association of haplotype TAC with the CVI occurrence in CA patients from Serbia. Replication and validation of our results are required.
T2  - Journal of Stroke and Cerebrovascular Diseases
T2  - Journal of Stroke and Cerebrovascular DiseasesJournal of Stroke and Cerebrovascular Diseases
T1  - Tag Variants of LGALS-3 Containing Haplotype Block in Advanced Carotid Atherosclerosis
VL  - 31
IS  - 1
SP  - 106212
DO  - 10.1016/j.jstrokecerebrovasdis.2021.106212
ER  - 

@article{
author = "Đorđević, Ana D. and Živković, Maja and Končar, Igor and Stanković, Aleksandra and Kuveljić, Jovana and Đurić, Tamara",
year = "2022",
abstract = "ObjectivesGalectin-3 affects a variety of biological processes. It is encoded by LGALS-3, located in unique haplotype block in Caucasians. Most of the studies regarding the gal-3 role in atherosclerosis are focused exclusively on protein/mRNA levels. Genetic analyses of LGALS-3 are scarce. We sought to thoroughly examine the genetic background of gal-3 and to analyze tag variants that cover more than 80% variability of the LGALS-3 containing hap-block in association with carotid plaque presence (CPP). According to Tagger server, rs4040064 G/T, rs11628437 G/A and rs7159490 C/T cover 82% (r2 > 0.8) of the genetic variance of this hap-block. Our aims were to investigate possible association of rs4040064, rs11628437 and rs7159490 haplotypes with CPP in patients with advanced carotid atherosclerosis (CA) and to analyze their possible effect on LGALS-3 mRNA expression in carotid plaques.Materials and methodsStudy group consisted of 468 patients and 296 controls. Rs4040064, rs11628437, rs7159490 and LGALS-3 mRNA expression were detected by TaqMan® technology.ResultsWe have found that haplotype TAC was associated with the cerebrovascular insult (CVI) occurrence (OR = 1.68, 95% CI = 1.09-2.58, p = 0.02), compared to the referent haplotype. OR was adjusted for hypertension, age and BMI. TAC also showed higher, but not statistically significant, LGALS-3 expression in carotid plaques.ConclusionsOur results suggest that rs4040064, rs11628437 and rs7159490 bear no association with CPP, neither they affect LGALS-3 mRNA in carotid plaques. However, we showed a significant association of haplotype TAC with the CVI occurrence in CA patients from Serbia. Replication and validation of our results are required.",
journal = "Journal of Stroke and Cerebrovascular Diseases, Journal of Stroke and Cerebrovascular DiseasesJournal of Stroke and Cerebrovascular Diseases",
title = "Tag Variants of LGALS-3 Containing Haplotype Block in Advanced Carotid Atherosclerosis",
volume = "31",
number = "1",
pages = "106212",
doi = "10.1016/j.jstrokecerebrovasdis.2021.106212"
}

Đorđević, A. D., Živković, M., Končar, I., Stanković, A., Kuveljić, J.,& Đurić, T.. (2022). Tag Variants of LGALS-3 Containing Haplotype Block in Advanced Carotid Atherosclerosis. in Journal of Stroke and Cerebrovascular Diseases, 31(1), 106212.
https://doi.org/10.1016/j.jstrokecerebrovasdis.2021.106212

Đorđević AD, Živković M, Končar I, Stanković A, Kuveljić J, Đurić T. Tag Variants of LGALS-3 Containing Haplotype Block in Advanced Carotid Atherosclerosis. in Journal of Stroke and Cerebrovascular Diseases. 2022;31(1):106212.
doi:10.1016/j.jstrokecerebrovasdis.2021.106212 .

Đorđević, Ana D., Živković, Maja, Končar, Igor, Stanković, Aleksandra, Kuveljić, Jovana, Đurić, Tamara, "Tag Variants of LGALS-3 Containing Haplotype Block in Advanced Carotid Atherosclerosis" in Journal of Stroke and Cerebrovascular Diseases, 31, no. 1 (2022):106212,
https://doi.org/10.1016/j.jstrokecerebrovasdis.2021.106212 . .

TY  - JOUR
AU  - Mitrović, Kristina
AU  - Životić, Ivan
AU  - Kolić, Ivana
AU  - Đorđević, Ana
AU  - Žakula, Jelena
AU  - Filipović Tričković, Jelena G.
AU  - Živković, Maja
AU  - Stanković, Aleksandra
AU  - Jovanović, Ivan G.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10469
AB  - Rare copy number variants (CNVs) are among the most common genomic disorders underlying CAKUT. miRNAs located in rare CNVs represent well-founded functional variants for human CAKUT research. The study aimed to identify and functionally interpret miRNAs most frequently affected by rare CNVs in CAKUT and to estimate the overall burden of rare CNVs on miRNA genes in CAKUT. The additional aim of this study was to experimentally confirm the effect of a rare CNV in CAKUT on candidate miRNA’s expression and the subsequent change in mRNA levels of selected target genes. A database of CAKUT-associated rare CNV regions, created by literature mining, was used for mapping of the miRNA precursors. miRNAs and miRNA families, most frequently affected by rare CAKUT-associated CNVs, have been subjected to bioinformatic analysis. CNV burden analysis was performed to identify chromosomes with over/underrepresentation of miRNA genes in rare CNVs associated with CAKUT. A functional study was performed on HEK293 MIR484+/- KO and HEK293 WT cell lines, followed by the analysis of relative miRNA and mRNA target gene levels. 80% of CAKUT patients with underlying rare CNV had at least one miRNA gene overlapping the identified CNV. Network analysis of the most frequently affected miRNAs has revealed the dominant regulation of the two miRNAs, hsa-miR-484 and hsa-miR-185-5p. Additionally, miR-548 family members have shown substantial enrichment in rare CNVs in CAKUT. An over/underrepresentation of miRNA genes in rare CNVs associated with CAKUT was observed in multiple chromosomes, such as chr16, chr20, and chr21. A significant 0.37 fold downregulation of hsa-miR-484, followed by a notable upregulation of MDM2 and APAF1 and downregulation of NOTCH3 was detected in HEK293 MIR484+/- KO compared to HEK293 WT cell lines, supporting the study hypothesis. miRNA genes are frequently affected by rare CNVs in CAKUT patients. Understanding the potential of CNV-affected miRNAs to participate in CAKUT as genetic drivers represent a crucial implication for the development of novel therapeutic approaches.
T2  - Scientific Reports
T1  - Identification and functional interpretation of miRNAs affected by rare CNVs in CAKUT
VL  - 12
IS  - 1
SP  - 17746
DO  - 10.1038/s41598-022-22749-1
ER  - 

@article{
author = "Mitrović, Kristina and Životić, Ivan and Kolić, Ivana and Đorđević, Ana and Žakula, Jelena and Filipović Tričković, Jelena G. and Živković, Maja and Stanković, Aleksandra and Jovanović, Ivan G.",
year = "2022",
abstract = "Rare copy number variants (CNVs) are among the most common genomic disorders underlying CAKUT. miRNAs located in rare CNVs represent well-founded functional variants for human CAKUT research. The study aimed to identify and functionally interpret miRNAs most frequently affected by rare CNVs in CAKUT and to estimate the overall burden of rare CNVs on miRNA genes in CAKUT. The additional aim of this study was to experimentally confirm the effect of a rare CNV in CAKUT on candidate miRNA’s expression and the subsequent change in mRNA levels of selected target genes. A database of CAKUT-associated rare CNV regions, created by literature mining, was used for mapping of the miRNA precursors. miRNAs and miRNA families, most frequently affected by rare CAKUT-associated CNVs, have been subjected to bioinformatic analysis. CNV burden analysis was performed to identify chromosomes with over/underrepresentation of miRNA genes in rare CNVs associated with CAKUT. A functional study was performed on HEK293 MIR484+/- KO and HEK293 WT cell lines, followed by the analysis of relative miRNA and mRNA target gene levels. 80% of CAKUT patients with underlying rare CNV had at least one miRNA gene overlapping the identified CNV. Network analysis of the most frequently affected miRNAs has revealed the dominant regulation of the two miRNAs, hsa-miR-484 and hsa-miR-185-5p. Additionally, miR-548 family members have shown substantial enrichment in rare CNVs in CAKUT. An over/underrepresentation of miRNA genes in rare CNVs associated with CAKUT was observed in multiple chromosomes, such as chr16, chr20, and chr21. A significant 0.37 fold downregulation of hsa-miR-484, followed by a notable upregulation of MDM2 and APAF1 and downregulation of NOTCH3 was detected in HEK293 MIR484+/- KO compared to HEK293 WT cell lines, supporting the study hypothesis. miRNA genes are frequently affected by rare CNVs in CAKUT patients. Understanding the potential of CNV-affected miRNAs to participate in CAKUT as genetic drivers represent a crucial implication for the development of novel therapeutic approaches.",
journal = "Scientific Reports",
title = "Identification and functional interpretation of miRNAs affected by rare CNVs in CAKUT",
volume = "12",
number = "1",
pages = "17746",
doi = "10.1038/s41598-022-22749-1"
}

Mitrović, K., Životić, I., Kolić, I., Đorđević, A., Žakula, J., Filipović Tričković, J. G., Živković, M., Stanković, A.,& Jovanović, I. G.. (2022). Identification and functional interpretation of miRNAs affected by rare CNVs in CAKUT. in Scientific Reports, 12(1), 17746.
https://doi.org/10.1038/s41598-022-22749-1

Mitrović K, Životić I, Kolić I, Đorđević A, Žakula J, Filipović Tričković JG, Živković M, Stanković A, Jovanović IG. Identification and functional interpretation of miRNAs affected by rare CNVs in CAKUT. in Scientific Reports. 2022;12(1):17746.
doi:10.1038/s41598-022-22749-1 .

Mitrović, Kristina, Životić, Ivan, Kolić, Ivana, Đorđević, Ana, Žakula, Jelena, Filipović Tričković, Jelena G., Živković, Maja, Stanković, Aleksandra, Jovanović, Ivan G., "Identification and functional interpretation of miRNAs affected by rare CNVs in CAKUT" in Scientific Reports, 12, no. 1 (2022):17746,
https://doi.org/10.1038/s41598-022-22749-1 . .

TY  - CONF
AU  - Dekleva, Milica
AU  - Đurić, Tamara
AU  - Đorđević, Ana
AU  - Soldatović, Ivan A.
AU  - Stanković, Aleksandra
AU  - Stevanović, Angelina
AU  - Živković, Maja
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10710
AB  - Cardiac remodeling after the first myocardial infarction (MI) appears to be more successful in women than in men, but more frequently associated with heart failure (HF) development. Galectin-3 expression is upregulated in remodeling and failing myocardium and circulatory level is activated in hypertrophy, fibrosis and inflammation.This study aimed to investigate the potential role of sex differences in the following: risk factors, structural and functional left ventricle (LV) changes, coronary angiography, expression of Galectin-3 and it's circulating level for HF occurrence during 6 months in patients after first MI.The prospective study included patients with the first MI treated with the primary percutaneous coronary intervention (p PCI) who underwent Doppler echocardiography within 2±1 days of MI and after 6 months. Relative LGALS-3 mRNA expression in peripheral blood were detected by TaqMan® technology. Expression and concentration of Galectin-3 was obtained by ELISA method. Presence of HF was confirmed by clinical examination and Doppler echocardiography. Assessment of p PCI and description of coronary angiography was performed at the patient's admission time.The study included 137 men and 44 women, who were significantly older (57.8 vs. 54.4, p=0.034), with higher LDL cholesterol (3.54±0.93 vs. 4.03±1.27, p=0.027) without differences among angiographic characteristics and medications. In the acute phase of MI, the significantly lower indexed LV volumes were found in women compared to men (EDLVI: 58.3 vs. 49.6, p<0.001, ESLVI: 33.84 vs. 26.83, p<0.001), but the grade of LV remodeling (delta LVDVI, delta LVESVI) during 6 months and changes in LV ejection fraction (deltaLVEF) were similar (p=ns). Incidence of LV hypertrophy and HF development was significantly higher in women 70% vs. 44.6%, p=0.034, 37.5% vs.19.3%, p=0.02). Females have had a higher degree of LV diastolic dysfunction (DD) in the early and late phase after MI (p=0.038, p=0.027). There were significant correlations between grade of DD and level of Gal-3 expression (p=0.001). The relative expression of LGALS-3 mRNA in peripheral blood was higher in females (p=0.007) with upregulation of circulating Gal-3 in females (44.66 vs. 16.30, p<0.001) and in HF patients (31.1 vs. 21.2, p=0.025).Sex specific actions such as LV hypertrophy, diastolic dysfunction, upregulation of Galectin-3 expression and higher circulating level may explain more incidence of HF in female. Difference in model and determinants of HF between men and women can be important for further therapy including Gelectin-3 inhibition.Type of funding sources: None.
C3  - European Heart Journal
T1  - Sex related difference in heart failure development in patients after first myocardial infarction; role of galectine-3
VL  - 43
IS  - Supplement 2
SP  - ehac544.816
DO  - 10.1093/eurheartj/ehac544.816
ER  - 

@conference{
author = "Dekleva, Milica and Đurić, Tamara and Đorđević, Ana and Soldatović, Ivan A. and Stanković, Aleksandra and Stevanović, Angelina and Živković, Maja",
year = "2022",
abstract = "Cardiac remodeling after the first myocardial infarction (MI) appears to be more successful in women than in men, but more frequently associated with heart failure (HF) development. Galectin-3 expression is upregulated in remodeling and failing myocardium and circulatory level is activated in hypertrophy, fibrosis and inflammation.This study aimed to investigate the potential role of sex differences in the following: risk factors, structural and functional left ventricle (LV) changes, coronary angiography, expression of Galectin-3 and it's circulating level for HF occurrence during 6 months in patients after first MI.The prospective study included patients with the first MI treated with the primary percutaneous coronary intervention (p PCI) who underwent Doppler echocardiography within 2±1 days of MI and after 6 months. Relative LGALS-3 mRNA expression in peripheral blood were detected by TaqMan® technology. Expression and concentration of Galectin-3 was obtained by ELISA method. Presence of HF was confirmed by clinical examination and Doppler echocardiography. Assessment of p PCI and description of coronary angiography was performed at the patient's admission time.The study included 137 men and 44 women, who were significantly older (57.8 vs. 54.4, p=0.034), with higher LDL cholesterol (3.54±0.93 vs. 4.03±1.27, p=0.027) without differences among angiographic characteristics and medications. In the acute phase of MI, the significantly lower indexed LV volumes were found in women compared to men (EDLVI: 58.3 vs. 49.6, p<0.001, ESLVI: 33.84 vs. 26.83, p<0.001), but the grade of LV remodeling (delta LVDVI, delta LVESVI) during 6 months and changes in LV ejection fraction (deltaLVEF) were similar (p=ns). Incidence of LV hypertrophy and HF development was significantly higher in women 70% vs. 44.6%, p=0.034, 37.5% vs.19.3%, p=0.02). Females have had a higher degree of LV diastolic dysfunction (DD) in the early and late phase after MI (p=0.038, p=0.027). There were significant correlations between grade of DD and level of Gal-3 expression (p=0.001). The relative expression of LGALS-3 mRNA in peripheral blood was higher in females (p=0.007) with upregulation of circulating Gal-3 in females (44.66 vs. 16.30, p<0.001) and in HF patients (31.1 vs. 21.2, p=0.025).Sex specific actions such as LV hypertrophy, diastolic dysfunction, upregulation of Galectin-3 expression and higher circulating level may explain more incidence of HF in female. Difference in model and determinants of HF between men and women can be important for further therapy including Gelectin-3 inhibition.Type of funding sources: None.",
journal = "European Heart Journal",
title = "Sex related difference in heart failure development in patients after first myocardial infarction; role of galectine-3",
volume = "43",
number = "Supplement 2",
pages = "ehac544.816",
doi = "10.1093/eurheartj/ehac544.816"
}

Dekleva, M., Đurić, T., Đorđević, A., Soldatović, I. A., Stanković, A., Stevanović, A.,& Živković, M.. (2022). Sex related difference in heart failure development in patients after first myocardial infarction; role of galectine-3. in European Heart Journal, 43(Supplement 2), ehac544.816.
https://doi.org/10.1093/eurheartj/ehac544.816

Dekleva M, Đurić T, Đorđević A, Soldatović IA, Stanković A, Stevanović A, Živković M. Sex related difference in heart failure development in patients after first myocardial infarction; role of galectine-3. in European Heart Journal. 2022;43(Supplement 2):ehac544.816.
doi:10.1093/eurheartj/ehac544.816 .

Dekleva, Milica, Đurić, Tamara, Đorđević, Ana, Soldatović, Ivan A., Stanković, Aleksandra, Stevanović, Angelina, Živković, Maja, "Sex related difference in heart failure development in patients after first myocardial infarction; role of galectine-3" in European Heart Journal, 43, no. Supplement 2 (2022):ehac544.816,
https://doi.org/10.1093/eurheartj/ehac544.816 . .

TY  - CONF
AU  - Mitrović, Kristina
AU  - Kolić, Ivana
AU  - Životić, Ivan
AU  - Filipović Tričković, Jelena G.
AU  - Đorđević, Ana
AU  - Živković, Maja
AU  - Stanković, Aleksandra
AU  - Jovanović, Ivan G.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10830
AB  - Introduction: miR-548 family members, located on all human chromosomes except chr19 and chrY, regulate podocyte differentiation in vitro, important for kidney development. Rare copy number variants (rCNVs) are the common genetic cause of Congenital Anomalies of the Kidney and Urinary Tract (CAKUT) and could harbour miRNAs. The aim of this study was to investigate to which extent rCNVs associated with CAKUT harbour miR-548 members.
Materials and Methods: Extensive literature review was conducted to collect data of pathogenic and likely pathogenic rCNVs in CAKUT patients. UCSC genome browser tool was employed for mapping of miR-548 members onto collected rCNV regions and gnomAD SV controls database. Bioinformatic analysis was conducted using miRPathDB2 tool.
Results: We generated CAKUT database of pathogenic CNVs in 79 chromosome regions from 191 patient and likely pathogenic CNVs in 74 regions from 87 patients. Pathogenic rCNVs of seventeen patients, located on 7 chromosomes, contained at least one miR-548 member. Likely pathogenic rCNVs of 4 patients, located on 3 chromosomes, contained one of miR-548 members. Bioinformatic analysis implied the role of mapped miRNAs in the regulation of processes associated with CAKUT. In controls, only hsa-mir-548i-3 (out of 73 precursors) was mapped on polymorphic CNVs (af>1%) and wasn’t identified in patients.
Conclusions: miR-548 members located in rCNVs should be investigated in future studies as potential genetic drivers of CAKUT development, beyond protein coding genes.
C3  - European Journal of Human Genetics
T1  - Are miR-548 family members potential genetic drivers of CAKUT
VL  - 30
IS  - Suppl. 1
SP  - 331
DO  - 10.1038/s41431-021-01026-1
ER  - 

@conference{
author = "Mitrović, Kristina and Kolić, Ivana and Životić, Ivan and Filipović Tričković, Jelena G. and Đorđević, Ana and Živković, Maja and Stanković, Aleksandra and Jovanović, Ivan G.",
year = "2022",
abstract = "Introduction: miR-548 family members, located on all human chromosomes except chr19 and chrY, regulate podocyte differentiation in vitro, important for kidney development. Rare copy number variants (rCNVs) are the common genetic cause of Congenital Anomalies of the Kidney and Urinary Tract (CAKUT) and could harbour miRNAs. The aim of this study was to investigate to which extent rCNVs associated with CAKUT harbour miR-548 members.
Materials and Methods: Extensive literature review was conducted to collect data of pathogenic and likely pathogenic rCNVs in CAKUT patients. UCSC genome browser tool was employed for mapping of miR-548 members onto collected rCNV regions and gnomAD SV controls database. Bioinformatic analysis was conducted using miRPathDB2 tool.
Results: We generated CAKUT database of pathogenic CNVs in 79 chromosome regions from 191 patient and likely pathogenic CNVs in 74 regions from 87 patients. Pathogenic rCNVs of seventeen patients, located on 7 chromosomes, contained at least one miR-548 member. Likely pathogenic rCNVs of 4 patients, located on 3 chromosomes, contained one of miR-548 members. Bioinformatic analysis implied the role of mapped miRNAs in the regulation of processes associated with CAKUT. In controls, only hsa-mir-548i-3 (out of 73 precursors) was mapped on polymorphic CNVs (af>1%) and wasn’t identified in patients.
Conclusions: miR-548 members located in rCNVs should be investigated in future studies as potential genetic drivers of CAKUT development, beyond protein coding genes.",
journal = "European Journal of Human Genetics",
title = "Are miR-548 family members potential genetic drivers of CAKUT",
volume = "30",
number = "Suppl. 1",
pages = "331",
doi = "10.1038/s41431-021-01026-1"
}

Mitrović, K., Kolić, I., Životić, I., Filipović Tričković, J. G., Đorđević, A., Živković, M., Stanković, A.,& Jovanović, I. G.. (2022). Are miR-548 family members potential genetic drivers of CAKUT. in European Journal of Human Genetics, 30(Suppl. 1), 331.
https://doi.org/10.1038/s41431-021-01026-1

Mitrović K, Kolić I, Životić I, Filipović Tričković JG, Đorđević A, Živković M, Stanković A, Jovanović IG. Are miR-548 family members potential genetic drivers of CAKUT. in European Journal of Human Genetics. 2022;30(Suppl. 1):331.
doi:10.1038/s41431-021-01026-1 .

Mitrović, Kristina, Kolić, Ivana, Životić, Ivan, Filipović Tričković, Jelena G., Đorđević, Ana, Živković, Maja, Stanković, Aleksandra, Jovanović, Ivan G., "Are miR-548 family members potential genetic drivers of CAKUT" in European Journal of Human Genetics, 30, no. Suppl. 1 (2022):331,
https://doi.org/10.1038/s41431-021-01026-1 . .

TY  - CONF
AU  - Životić, Ivan
AU  - Kolić, Ivana
AU  - Popić, Kristina
AU  - Filipović Tričković, Jelena G.
AU  - Đorđević, Ana
AU  - Živković, Maja
AU  - Stanković, Aleksandra
AU  - Jovanović, Ivan G.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10831
AB  - Introduction: Genetic studies of congenital anomalies of the kidney and urinary tract (CAKUT) have demonstrated variable penetrability and expressivity of the associated genetic defects. Previously, it was shown that deletions of 17q12 and 22q11.2 regions were specific for kidney anomalies (KA) while 16p11.2 and 1q21.1 loci showed extensive pleiotropy in CAKUT phenotypes. CNVs affecting miRNA gene dosage have been described to have functional influence on gene expression. We aimed to conduct comprehensive in silico analysis using publicly available databases to analyze miRNA content of CAKUT-associated CNVs in quoted chromosomal loci with regard to pleiotropy.  Methods: Extensive literature review was conducted to collect data about pathogenic rCNVs associated with CAKUT. UCSC genome browser tool was employed for mapping miRNAs onto collected rCNV regions.  Results: Analysis of CNVs in CAKUT included four studies counting more than 2500 patients. In further analysis we included 191 patients harboring pathogenic CNVs. Surprisingly, CAKUT pleiotropic regions (16p11.2, 1q21.2) did not contain any miRNA. 22q11.2 showed the densest miRNAs content (n = 21).  Conclusions: Absence of miRNAs may potentially pronounce the pleiotropy of the CAKUT genetic defects, thus leading to the variety of phenotypes. Contrary, abundancy of miRNAs in 22q11.2 might be associated with reproducible phenotype, such as KA, producing the functional effect when deleted. This assumption agrees with recent results of miRNA expression variability in 22q11.2 deletion syndrome.
C3  - European Journal of Human Genetics
T1  - miRNA-free rare pathogenic CNVs could drive toward variable CAKUT phenotypes
VL  - 30
IS  - Suppl. 1
SP  - 331
DO  - 10.1038/s41431-021-01026-1
ER  - 

@conference{
author = "Životić, Ivan and Kolić, Ivana and Popić, Kristina and Filipović Tričković, Jelena G. and Đorđević, Ana and Živković, Maja and Stanković, Aleksandra and Jovanović, Ivan G.",
year = "2022",
abstract = "Introduction: Genetic studies of congenital anomalies of the kidney and urinary tract (CAKUT) have demonstrated variable penetrability and expressivity of the associated genetic defects. Previously, it was shown that deletions of 17q12 and 22q11.2 regions were specific for kidney anomalies (KA) while 16p11.2 and 1q21.1 loci showed extensive pleiotropy in CAKUT phenotypes. CNVs affecting miRNA gene dosage have been described to have functional influence on gene expression. We aimed to conduct comprehensive in silico analysis using publicly available databases to analyze miRNA content of CAKUT-associated CNVs in quoted chromosomal loci with regard to pleiotropy.  Methods: Extensive literature review was conducted to collect data about pathogenic rCNVs associated with CAKUT. UCSC genome browser tool was employed for mapping miRNAs onto collected rCNV regions.  Results: Analysis of CNVs in CAKUT included four studies counting more than 2500 patients. In further analysis we included 191 patients harboring pathogenic CNVs. Surprisingly, CAKUT pleiotropic regions (16p11.2, 1q21.2) did not contain any miRNA. 22q11.2 showed the densest miRNAs content (n = 21).  Conclusions: Absence of miRNAs may potentially pronounce the pleiotropy of the CAKUT genetic defects, thus leading to the variety of phenotypes. Contrary, abundancy of miRNAs in 22q11.2 might be associated with reproducible phenotype, such as KA, producing the functional effect when deleted. This assumption agrees with recent results of miRNA expression variability in 22q11.2 deletion syndrome.",
journal = "European Journal of Human Genetics",
title = "miRNA-free rare pathogenic CNVs could drive toward variable CAKUT phenotypes",
volume = "30",
number = "Suppl. 1",
pages = "331",
doi = "10.1038/s41431-021-01026-1"
}

Životić, I., Kolić, I., Popić, K., Filipović Tričković, J. G., Đorđević, A., Živković, M., Stanković, A.,& Jovanović, I. G.. (2022). miRNA-free rare pathogenic CNVs could drive toward variable CAKUT phenotypes. in European Journal of Human Genetics, 30(Suppl. 1), 331.
https://doi.org/10.1038/s41431-021-01026-1

Životić I, Kolić I, Popić K, Filipović Tričković JG, Đorđević A, Živković M, Stanković A, Jovanović IG. miRNA-free rare pathogenic CNVs could drive toward variable CAKUT phenotypes. in European Journal of Human Genetics. 2022;30(Suppl. 1):331.
doi:10.1038/s41431-021-01026-1 .

Životić, Ivan, Kolić, Ivana, Popić, Kristina, Filipović Tričković, Jelena G., Đorđević, Ana, Živković, Maja, Stanković, Aleksandra, Jovanović, Ivan G., "miRNA-free rare pathogenic CNVs could drive toward variable CAKUT phenotypes" in European Journal of Human Genetics, 30, no. Suppl. 1 (2022):331,
https://doi.org/10.1038/s41431-021-01026-1 . .

TY  - CONF
AU  - Kolić, Ivana
AU  - Mitrović, Kristina
AU  - Životić, Ivan
AU  - Đorđević, Ana
AU  - Filipović-Tričković, Jelena
AU  - Živković, Maja
AU  - Stanković, Aleksandra
AU  - Jovanović, Ivan
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12684
AB  - Background/Objectives: Rare copy number variants (rCNVs) are the common genetic cause of Congenital Anomalies of the Kidney and Urinary Tract (CAKUT).1 miRNAs located in rCNVs represent well-founded functional variants for human CAKUT research. However, the impact of rCNVs on miRNA genes in CAKUT is unknown. Thus, burden assessment was performed to identify chromosomes with non-random representation of miRNA genes in rCNVs associated with CAKUT. Methods: A comprehensive literature mining of rCNV regions associated with CAKUT was performed. The total cumulative length of rCNVs per chromosome was the sum of corresponding CNV-DNA regions, taking into account overlapping. Mapping of miRNAs onto cumulative rCNV regions gave counts of affected miRNA loci. The correlation analysis was performed between the number of miRNA genes overlapping rCNVs, and the fractional lengths of cumulative rCNVs regions in relation to the chromosome size. Results: A statistically significant positive correlation was observed for duplications and deletions respectively (Spearman correlation p<0.0001, r=0.9, r=0.8). However, a deviation from the best fit line for chromosome 16, for both rare duplications and deletions, was observed due to the high overrepresentation of miRNA genes in identified rCNVs. Conclusion: The current finding of the high overall burden of rCNVs on miRNA genes in chromosome 16 suggests that miRNAs located on this chromosome could serve as candidates for the investigation of miRNA role in CAKUT development.
C3  - 54th European Society of Human Genetics (ESHG) : Book of abstracts
T1  - Assessing the burden of rare CNVs on miRNA genes in CAKUT
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12684
ER  - 

@conference{
author = "Kolić, Ivana and Mitrović, Kristina and Životić, Ivan and Đorđević, Ana and Filipović-Tričković, Jelena and Živković, Maja and Stanković, Aleksandra and Jovanović, Ivan",
year = "2022",
abstract = "Background/Objectives: Rare copy number variants (rCNVs) are the common genetic cause of Congenital Anomalies of the Kidney and Urinary Tract (CAKUT).1 miRNAs located in rCNVs represent well-founded functional variants for human CAKUT research. However, the impact of rCNVs on miRNA genes in CAKUT is unknown. Thus, burden assessment was performed to identify chromosomes with non-random representation of miRNA genes in rCNVs associated with CAKUT. Methods: A comprehensive literature mining of rCNV regions associated with CAKUT was performed. The total cumulative length of rCNVs per chromosome was the sum of corresponding CNV-DNA regions, taking into account overlapping. Mapping of miRNAs onto cumulative rCNV regions gave counts of affected miRNA loci. The correlation analysis was performed between the number of miRNA genes overlapping rCNVs, and the fractional lengths of cumulative rCNVs regions in relation to the chromosome size. Results: A statistically significant positive correlation was observed for duplications and deletions respectively (Spearman correlation p<0.0001, r=0.9, r=0.8). However, a deviation from the best fit line for chromosome 16, for both rare duplications and deletions, was observed due to the high overrepresentation of miRNA genes in identified rCNVs. Conclusion: The current finding of the high overall burden of rCNVs on miRNA genes in chromosome 16 suggests that miRNAs located on this chromosome could serve as candidates for the investigation of miRNA role in CAKUT development.",
journal = "54th European Society of Human Genetics (ESHG) : Book of abstracts",
title = "Assessing the burden of rare CNVs on miRNA genes in CAKUT",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12684"
}

Kolić, I., Mitrović, K., Životić, I., Đorđević, A., Filipović-Tričković, J., Živković, M., Stanković, A.,& Jovanović, I.. (2022). Assessing the burden of rare CNVs on miRNA genes in CAKUT. in 54th European Society of Human Genetics (ESHG) : Book of abstracts.
https://hdl.handle.net/21.15107/rcub_vinar_12684

Kolić I, Mitrović K, Životić I, Đorđević A, Filipović-Tričković J, Živković M, Stanković A, Jovanović I. Assessing the burden of rare CNVs on miRNA genes in CAKUT. in 54th European Society of Human Genetics (ESHG) : Book of abstracts. 2022;.
https://hdl.handle.net/21.15107/rcub_vinar_12684 .

Kolić, Ivana, Mitrović, Kristina, Životić, Ivan, Đorđević, Ana, Filipović-Tričković, Jelena, Živković, Maja, Stanković, Aleksandra, Jovanović, Ivan, "Assessing the burden of rare CNVs on miRNA genes in CAKUT" in 54th European Society of Human Genetics (ESHG) : Book of abstracts (2022),
https://hdl.handle.net/21.15107/rcub_vinar_12684 .

TY  - JOUR
AU  - Đurić, Tamara
AU  - Kuveljić, Jovana
AU  - Đorđević, Ana
AU  - Dekleva, Milica
AU  - Stanković, Goran
AU  - Stanković, Aleksandra
AU  - Živković, Maja
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10382
AB  - Background Myocardial infarction (MI) leads to ischemia and afterward to left ventricular (LV) remodeling. Matrix metalloproteinase−1 (MMP1) and −3 (MMP3) belong to the family of endopeptidases and together they can dissolve most of the components of the extracellular matrix. MMP1 and MMP3 variants have been investigated solely in association with ischemic heart disease and LV dysfunction, but not in haplotype. The aims of this study were to investigate the association of haplotypes inferred from MMP1 rs1799750 (−1607 1G/2G; NC_000011.9:g.102670497del) and MMP3 rs35068180 (−1612 5A/6A; NC_000011.9:g.102715952dup) with MI and their effect on the change in echocardiographic parameters of LV structure and function in patients within 6 months after MI. Methods The study included 325 patients with the first MI and 283 healthy controls. Gene variants were detected by PCR-RFLP method. Parameters of LV structure and function were assessed by conventional 2D echocardiography, 3–5 days and 6 months after the first MI, on a subgroup of 160 patients. Haplotype analysis was performed with Thesias software. Results Haplotypes 2G-5A and 1G-6A were significantly and independently associated with MI compared with the reference haplotype 2G-6A (adjusted, p = 0.009 and p = 0.026, respectively). After Bonferroni correction for multiple testing, MMP1 and MMP3 haplotypes lost their association with the change in LV long diameter and stroke volume within 6 months after MI. Conclusion MMP1 and MMP3 haplotypes are strongly associated with MI. Further studies are needed to validate this result and to examine their association with echocardiographic parameters of LV structure and function after MI.
T2  - Molecular Genetics & Genomic Medicine
T1  - Association of MMP1 and MMP3 haplotypes with myocardial infarction and echocardiographic parameters of the left ventricle
VL  - 10
IS  - 9
SP  - e2022
DO  - 10.1002/mgg3.2022
ER  - 

@article{
author = "Đurić, Tamara and Kuveljić, Jovana and Đorđević, Ana and Dekleva, Milica and Stanković, Goran and Stanković, Aleksandra and Živković, Maja",
year = "2022",
abstract = "Background Myocardial infarction (MI) leads to ischemia and afterward to left ventricular (LV) remodeling. Matrix metalloproteinase−1 (MMP1) and −3 (MMP3) belong to the family of endopeptidases and together they can dissolve most of the components of the extracellular matrix. MMP1 and MMP3 variants have been investigated solely in association with ischemic heart disease and LV dysfunction, but not in haplotype. The aims of this study were to investigate the association of haplotypes inferred from MMP1 rs1799750 (−1607 1G/2G; NC_000011.9:g.102670497del) and MMP3 rs35068180 (−1612 5A/6A; NC_000011.9:g.102715952dup) with MI and their effect on the change in echocardiographic parameters of LV structure and function in patients within 6 months after MI. Methods The study included 325 patients with the first MI and 283 healthy controls. Gene variants were detected by PCR-RFLP method. Parameters of LV structure and function were assessed by conventional 2D echocardiography, 3–5 days and 6 months after the first MI, on a subgroup of 160 patients. Haplotype analysis was performed with Thesias software. Results Haplotypes 2G-5A and 1G-6A were significantly and independently associated with MI compared with the reference haplotype 2G-6A (adjusted, p = 0.009 and p = 0.026, respectively). After Bonferroni correction for multiple testing, MMP1 and MMP3 haplotypes lost their association with the change in LV long diameter and stroke volume within 6 months after MI. Conclusion MMP1 and MMP3 haplotypes are strongly associated with MI. Further studies are needed to validate this result and to examine their association with echocardiographic parameters of LV structure and function after MI.",
journal = "Molecular Genetics & Genomic Medicine",
title = "Association of MMP1 and MMP3 haplotypes with myocardial infarction and echocardiographic parameters of the left ventricle",
volume = "10",
number = "9",
pages = "e2022",
doi = "10.1002/mgg3.2022"
}

Đurić, T., Kuveljić, J., Đorđević, A., Dekleva, M., Stanković, G., Stanković, A.,& Živković, M.. (2022). Association of MMP1 and MMP3 haplotypes with myocardial infarction and echocardiographic parameters of the left ventricle. in Molecular Genetics & Genomic Medicine, 10(9), e2022.
https://doi.org/10.1002/mgg3.2022

Đurić T, Kuveljić J, Đorđević A, Dekleva M, Stanković G, Stanković A, Živković M. Association of MMP1 and MMP3 haplotypes with myocardial infarction and echocardiographic parameters of the left ventricle. in Molecular Genetics & Genomic Medicine. 2022;10(9):e2022.
doi:10.1002/mgg3.2022 .

Đurić, Tamara, Kuveljić, Jovana, Đorđević, Ana, Dekleva, Milica, Stanković, Goran, Stanković, Aleksandra, Živković, Maja, "Association of MMP1 and MMP3 haplotypes with myocardial infarction and echocardiographic parameters of the left ventricle" in Molecular Genetics & Genomic Medicine, 10, no. 9 (2022):e2022,
https://doi.org/10.1002/mgg3.2022 . .

TY  - CONF
AU  - Đorđević, Ana M.
AU  - Dekleva, Milica
AU  - Živković, Maja
AU  - Stanković, Aleksandra
AU  - Kuveljić, Jovana
AU  - Đurić, Tamara
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12729
AB  - After myocardial infarction (MI) and consequential ischemia, the heart undergoes a set of geometric and functional changes. In the early days after injury, these changes, defined as cardiac remodeling, are the powerful factor that preserves cardiac function and promotes survival. However, it may continue for months after MI and eventually lead to adverse remodeling with impaired systolic function and reduced myocardial contractility and further cardiovascular complications, such as heart failure (HF). Left ventricular (LV) ejection fraction (EF) is widely used as an index of systolic function in cardiac patients. However, global myocardial strain has been found to be superior to the conventional parameters, such as LVEF, in terms of assessment of cardiac performance after MI. Galectin-3 (gal-3) is a multifunctional protein involved in a variety of physiological and pathological processes, affecting the entire cardiovascular continuum of MI. Gal-3 is encoded by a LGALS-3 gene, located in a unique, 300 kb long haplotype block in Caucasians. Gal-3 serum level has been approved as a diagnostic marker for risk stratification and prognosis evaluation of HF patients according to the ACC/AHA/HFSA Guideline for the management of HF. The purpose of the present prospective study was to analyze the possible association of tag genetic variants of the haplotype block containing LGALS-3 with changes in cardiac parameters, LVEF and global radial strain (GRS), within 6 months post-MI. The study enrolled 120 patients with first acute MI that were prospectively followed-up 6 months after MI. According to Tagger server, rs4040064 G/T, rs11628437 G/A and rs7159490 C/T variants cover 82% (r2>0.8) of phenotypic variance of the aforementioned haplotype block. Tag variants were detected and genotyped by commercially available assays for allelic discrimination. Echocardiography examinations were performed at admission and 6 months post-MI. Change (Δ) of cardiac parameters was calculated as a difference between the value at 6-month follow-up and baseline value (at admission). The referent haplotype is set by the software for carrying haplotype association analysis and represents the most frequent haplotype in the studied groups. Bonferroni correction for multiple testing was performed and p values <0.025 were considered as statistically significant.We found that, compared to the reference GGC haplotype, GAT haplotype had significantly higher expected phenotypic mean [95% CI] of ΔGRS (3.77 [1.28 - 6.25] vs. −5.34 [−12.69 - 2.01], respectively, p=0.025) and ΔLVEF (0.84 [−1.88 - 3.56] vs. −12.91 [−17.30 - −8.53], respectively, p=0.00001), in the direction of decrease of GRS and LVEF 6 months after MI in patients bearing GAT haplotype. Our findings suggest that GAT haplotype bears the risk for diminished LV transmural contractility and radial systolic function: In order to reach a definitive conclusion, our exploratory results should be further validated on a larger sample
C3  - European Journal of Hear Failure
T1  - LGALS-3 containing haplotype block tag variants in association with cardiac parameters changes within six months after the first acute myocardial infarction
VL  - 23
IS  - Suppl. S2
SP  - 311
EP  - 311
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12729
ER  - 

@conference{
author = "Đorđević, Ana M. and Dekleva, Milica and Živković, Maja and Stanković, Aleksandra and Kuveljić, Jovana and Đurić, Tamara",
year = "2021",
abstract = "After myocardial infarction (MI) and consequential ischemia, the heart undergoes a set of geometric and functional changes. In the early days after injury, these changes, defined as cardiac remodeling, are the powerful factor that preserves cardiac function and promotes survival. However, it may continue for months after MI and eventually lead to adverse remodeling with impaired systolic function and reduced myocardial contractility and further cardiovascular complications, such as heart failure (HF). Left ventricular (LV) ejection fraction (EF) is widely used as an index of systolic function in cardiac patients. However, global myocardial strain has been found to be superior to the conventional parameters, such as LVEF, in terms of assessment of cardiac performance after MI. Galectin-3 (gal-3) is a multifunctional protein involved in a variety of physiological and pathological processes, affecting the entire cardiovascular continuum of MI. Gal-3 is encoded by a LGALS-3 gene, located in a unique, 300 kb long haplotype block in Caucasians. Gal-3 serum level has been approved as a diagnostic marker for risk stratification and prognosis evaluation of HF patients according to the ACC/AHA/HFSA Guideline for the management of HF. The purpose of the present prospective study was to analyze the possible association of tag genetic variants of the haplotype block containing LGALS-3 with changes in cardiac parameters, LVEF and global radial strain (GRS), within 6 months post-MI. The study enrolled 120 patients with first acute MI that were prospectively followed-up 6 months after MI. According to Tagger server, rs4040064 G/T, rs11628437 G/A and rs7159490 C/T variants cover 82% (r2>0.8) of phenotypic variance of the aforementioned haplotype block. Tag variants were detected and genotyped by commercially available assays for allelic discrimination. Echocardiography examinations were performed at admission and 6 months post-MI. Change (Δ) of cardiac parameters was calculated as a difference between the value at 6-month follow-up and baseline value (at admission). The referent haplotype is set by the software for carrying haplotype association analysis and represents the most frequent haplotype in the studied groups. Bonferroni correction for multiple testing was performed and p values <0.025 were considered as statistically significant.We found that, compared to the reference GGC haplotype, GAT haplotype had significantly higher expected phenotypic mean [95% CI] of ΔGRS (3.77 [1.28 - 6.25] vs. −5.34 [−12.69 - 2.01], respectively, p=0.025) and ΔLVEF (0.84 [−1.88 - 3.56] vs. −12.91 [−17.30 - −8.53], respectively, p=0.00001), in the direction of decrease of GRS and LVEF 6 months after MI in patients bearing GAT haplotype. Our findings suggest that GAT haplotype bears the risk for diminished LV transmural contractility and radial systolic function: In order to reach a definitive conclusion, our exploratory results should be further validated on a larger sample",
journal = "European Journal of Hear Failure",
title = "LGALS-3 containing haplotype block tag variants in association with cardiac parameters changes within six months after the first acute myocardial infarction",
volume = "23",
number = "Suppl. S2",
pages = "311-311",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12729"
}

Đorđević, A. M., Dekleva, M., Živković, M., Stanković, A., Kuveljić, J.,& Đurić, T.. (2021). LGALS-3 containing haplotype block tag variants in association with cardiac parameters changes within six months after the first acute myocardial infarction. in European Journal of Hear Failure, 23(Suppl. S2), 311-311.
https://hdl.handle.net/21.15107/rcub_vinar_12729

Đorđević AM, Dekleva M, Živković M, Stanković A, Kuveljić J, Đurić T. LGALS-3 containing haplotype block tag variants in association with cardiac parameters changes within six months after the first acute myocardial infarction. in European Journal of Hear Failure. 2021;23(Suppl. S2):311-311.
https://hdl.handle.net/21.15107/rcub_vinar_12729 .

Đorđević, Ana M., Dekleva, Milica, Živković, Maja, Stanković, Aleksandra, Kuveljić, Jovana, Đurić, Tamara, "LGALS-3 containing haplotype block tag variants in association with cardiac parameters changes within six months after the first acute myocardial infarction" in European Journal of Hear Failure, 23, no. Suppl. S2 (2021):311-311,
https://hdl.handle.net/21.15107/rcub_vinar_12729 .

TY  - JOUR
AU  - Stojković, Ljiljana S.
AU  - Jovanović, Ivan G.
AU  - Živković, Maja
AU  - Zec, Manja
AU  - Đurić, Tamara
AU  - Životić, Ivan
AU  - Kuveljić, Jovana
AU  - Kolaković, Ana
AU  - Kolić, Ivana
AU  - Đorđević, Ana
AU  - Glibetić, Marija
AU  - Alavantić, Dragan
AU  - Stanković, Aleksandra
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8683
AB  - Foods and food products that contain polyphenols are proposed to modulate risk of cardiovascular disease. The aim of this three-arm, crossover, randomized, double-blind, placebo-controlled intervention study was to examine the impact of Aronia melanocarpa juice (AMJ), high-polyphenol (AMJ treatment, 1.17 g/100 mL polyphenols) and low-polyphenol (dAMJ treatment, 0.29 g/100 mL polyphenols) dose, on the transcriptome in peripheral blood mononuclear cells (PBMC) of 19 subjects at cardiovascular risk. Transcriptome data were obtained by microarray. Bioinformatic functional annotation analysis was performed on both the whole transcriptome datasets and the differentially expressed genes (DEGs). Expression of selected DEGs was validated by RT-qPCR. Administration of AMJ and dAMJ treatments during the two consecutive four-week treatment periods had additive effects on PBMC transcriptome profiles, with the most pronounced and specific effect noticed for AMJ in the last treatment period (TP3) of the trial. Between the high-dose and low-dose treatments in TP3, there was a multitude of overlapping DEGs and DEG-enriched biological processes and pathways, which primarily included immunomodulation and regulation of cell proliferation/death. Increased expression of TNF, IL1B, IL8, RGS1, OSM, and DUSP2 in TP3 was confirmed by RT-qPCR. The results suggest the immunomodulatory effects of prolonged habitual consumption of polyphenol-rich aronia juice in individuals at cardiovascular risk.
T2  - Nutrients
T1  - The Effects of Aronia melanocarpa Juice Consumption on the mRNA Expression Profile in Peripheral Blood Mononuclear Cells in Subjects at Cardiovascular Risk
VL  - 12
IS  - 5
SP  - 1484
DO  - 10.3390/nu12051484
ER  - 

@article{
author = "Stojković, Ljiljana S. and Jovanović, Ivan G. and Živković, Maja and Zec, Manja and Đurić, Tamara and Životić, Ivan and Kuveljić, Jovana and Kolaković, Ana and Kolić, Ivana and Đorđević, Ana and Glibetić, Marija and Alavantić, Dragan and Stanković, Aleksandra",
year = "2020",
abstract = "Foods and food products that contain polyphenols are proposed to modulate risk of cardiovascular disease. The aim of this three-arm, crossover, randomized, double-blind, placebo-controlled intervention study was to examine the impact of Aronia melanocarpa juice (AMJ), high-polyphenol (AMJ treatment, 1.17 g/100 mL polyphenols) and low-polyphenol (dAMJ treatment, 0.29 g/100 mL polyphenols) dose, on the transcriptome in peripheral blood mononuclear cells (PBMC) of 19 subjects at cardiovascular risk. Transcriptome data were obtained by microarray. Bioinformatic functional annotation analysis was performed on both the whole transcriptome datasets and the differentially expressed genes (DEGs). Expression of selected DEGs was validated by RT-qPCR. Administration of AMJ and dAMJ treatments during the two consecutive four-week treatment periods had additive effects on PBMC transcriptome profiles, with the most pronounced and specific effect noticed for AMJ in the last treatment period (TP3) of the trial. Between the high-dose and low-dose treatments in TP3, there was a multitude of overlapping DEGs and DEG-enriched biological processes and pathways, which primarily included immunomodulation and regulation of cell proliferation/death. Increased expression of TNF, IL1B, IL8, RGS1, OSM, and DUSP2 in TP3 was confirmed by RT-qPCR. The results suggest the immunomodulatory effects of prolonged habitual consumption of polyphenol-rich aronia juice in individuals at cardiovascular risk.",
journal = "Nutrients",
title = "The Effects of Aronia melanocarpa Juice Consumption on the mRNA Expression Profile in Peripheral Blood Mononuclear Cells in Subjects at Cardiovascular Risk",
volume = "12",
number = "5",
pages = "1484",
doi = "10.3390/nu12051484"
}

Stojković, L. S., Jovanović, I. G., Živković, M., Zec, M., Đurić, T., Životić, I., Kuveljić, J., Kolaković, A., Kolić, I., Đorđević, A., Glibetić, M., Alavantić, D.,& Stanković, A.. (2020). The Effects of Aronia melanocarpa Juice Consumption on the mRNA Expression Profile in Peripheral Blood Mononuclear Cells in Subjects at Cardiovascular Risk. in Nutrients, 12(5), 1484.
https://doi.org/10.3390/nu12051484

Stojković LS, Jovanović IG, Živković M, Zec M, Đurić T, Životić I, Kuveljić J, Kolaković A, Kolić I, Đorđević A, Glibetić M, Alavantić D, Stanković A. The Effects of Aronia melanocarpa Juice Consumption on the mRNA Expression Profile in Peripheral Blood Mononuclear Cells in Subjects at Cardiovascular Risk. in Nutrients. 2020;12(5):1484.
doi:10.3390/nu12051484 .

Stojković, Ljiljana S., Jovanović, Ivan G., Živković, Maja, Zec, Manja, Đurić, Tamara, Životić, Ivan, Kuveljić, Jovana, Kolaković, Ana, Kolić, Ivana, Đorđević, Ana, Glibetić, Marija, Alavantić, Dragan, Stanković, Aleksandra, "The Effects of Aronia melanocarpa Juice Consumption on the mRNA Expression Profile in Peripheral Blood Mononuclear Cells in Subjects at Cardiovascular Risk" in Nutrients, 12, no. 5 (2020):1484,
https://doi.org/10.3390/nu12051484 . .

TY  - JOUR
AU  - Romić, Snježana Đ.
AU  - Đorđević, Ana
AU  - Tepavčević, Snežana
AU  - Ćulafić, Tijana
AU  - Stojiljković, Mojca D.
AU  - Bursać, Biljana
AU  - Stanišić, Jelena
AU  - Kostić, Milan
AU  - Gligorovska, Ljupka
AU  - Korićanac, Goran
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8849
AB  - Both a diet rich in fructose and chronic stress exposure induce metabolic and cardiovascular disturbances. The aim of this study was to examine the effects of the fructose-rich diet and chronic stress, separately and in combination, on insulin signaling and molecules regulating glycogen synthesis and ion transport in the heart, and to reveal whether these effects coincide with changes in glucocorticoid receptor (GR) activation. Male Wistar rats were subjected to 10% fructose in drinking water and/or to chronic unpredictable stress for 9 weeks. Protein expression and/or phosphorylation of the insulin receptor (IR), protein tyrosine phosphatase 1B, insulin receptor substrate 1 (IRS1), protein kinase B (Akt), extracellular signal-regulated kinase 1/2 (ERK1/2), glycogen synthase kinase-3β (GSK-3β) and Na+/K+-ATPase α-subunits in cardiac tissue were analyzed by western blot. GR distribution between cytosolic and nuclear fractions was also analyzed. The fructose-rich diet decreased the level of pERK1/2 (Thr202/Tyr204) and pGSK-3β (Ser9) independently of stress, while chronic stress increased the IRS1 content and prevented the fructose diet-induced decrease of the pAkt (Ser473) level. The fructose-rich diet in combination with chronic stress reduced the protein content of cardiac IR and attenuated IRS1 upregulation. Separate treatments increased the protein content of Na+/K+-ATPase α1- and α2-subunits, while after combined treatment the α2 content was at the control level and the α1 content was lower than the control level. The effect of combined treatment on cardiac IR and α2-subunit expression could be mediated by increased GR nuclear accumulation. Our study provides new insights into the effects of chronic stress and a combination of the fructose diet and chronic stress on the studied molecules in the heart.
T2  - Food and Function
T1  - Effects of a fructose-rich diet and chronic stress on insulin signaling and regulation of glycogen synthase kinase-3 beta and the sodium–potassium pump in the hearts of male rats
VL  - 11
IS  - 2
SP  - 1455
EP  - 1466
DO  - 10.1039/C9FO02306B
ER  - 

@article{
author = "Romić, Snježana Đ. and Đorđević, Ana and Tepavčević, Snežana and Ćulafić, Tijana and Stojiljković, Mojca D. and Bursać, Biljana and Stanišić, Jelena and Kostić, Milan and Gligorovska, Ljupka and Korićanac, Goran",
year = "2020",
abstract = "Both a diet rich in fructose and chronic stress exposure induce metabolic and cardiovascular disturbances. The aim of this study was to examine the effects of the fructose-rich diet and chronic stress, separately and in combination, on insulin signaling and molecules regulating glycogen synthesis and ion transport in the heart, and to reveal whether these effects coincide with changes in glucocorticoid receptor (GR) activation. Male Wistar rats were subjected to 10% fructose in drinking water and/or to chronic unpredictable stress for 9 weeks. Protein expression and/or phosphorylation of the insulin receptor (IR), protein tyrosine phosphatase 1B, insulin receptor substrate 1 (IRS1), protein kinase B (Akt), extracellular signal-regulated kinase 1/2 (ERK1/2), glycogen synthase kinase-3β (GSK-3β) and Na+/K+-ATPase α-subunits in cardiac tissue were analyzed by western blot. GR distribution between cytosolic and nuclear fractions was also analyzed. The fructose-rich diet decreased the level of pERK1/2 (Thr202/Tyr204) and pGSK-3β (Ser9) independently of stress, while chronic stress increased the IRS1 content and prevented the fructose diet-induced decrease of the pAkt (Ser473) level. The fructose-rich diet in combination with chronic stress reduced the protein content of cardiac IR and attenuated IRS1 upregulation. Separate treatments increased the protein content of Na+/K+-ATPase α1- and α2-subunits, while after combined treatment the α2 content was at the control level and the α1 content was lower than the control level. The effect of combined treatment on cardiac IR and α2-subunit expression could be mediated by increased GR nuclear accumulation. Our study provides new insights into the effects of chronic stress and a combination of the fructose diet and chronic stress on the studied molecules in the heart.",
journal = "Food and Function",
title = "Effects of a fructose-rich diet and chronic stress on insulin signaling and regulation of glycogen synthase kinase-3 beta and the sodium–potassium pump in the hearts of male rats",
volume = "11",
number = "2",
pages = "1455-1466",
doi = "10.1039/C9FO02306B"
}

Romić, S. Đ., Đorđević, A., Tepavčević, S., Ćulafić, T., Stojiljković, M. D., Bursać, B., Stanišić, J., Kostić, M., Gligorovska, L.,& Korićanac, G.. (2020). Effects of a fructose-rich diet and chronic stress on insulin signaling and regulation of glycogen synthase kinase-3 beta and the sodium–potassium pump in the hearts of male rats. in Food and Function, 11(2), 1455-1466.
https://doi.org/10.1039/C9FO02306B

Romić SĐ, Đorđević A, Tepavčević S, Ćulafić T, Stojiljković MD, Bursać B, Stanišić J, Kostić M, Gligorovska L, Korićanac G. Effects of a fructose-rich diet and chronic stress on insulin signaling and regulation of glycogen synthase kinase-3 beta and the sodium–potassium pump in the hearts of male rats. in Food and Function. 2020;11(2):1455-1466.
doi:10.1039/C9FO02306B .

Romić, Snježana Đ., Đorđević, Ana, Tepavčević, Snežana, Ćulafić, Tijana, Stojiljković, Mojca D., Bursać, Biljana, Stanišić, Jelena, Kostić, Milan, Gligorovska, Ljupka, Korićanac, Goran, "Effects of a fructose-rich diet and chronic stress on insulin signaling and regulation of glycogen synthase kinase-3 beta and the sodium–potassium pump in the hearts of male rats" in Food and Function, 11, no. 2 (2020):1455-1466,
https://doi.org/10.1039/C9FO02306B . .

TY  - THES
AU  - Đorđević, Ana M.
PY  - 2019
UR  - https://plus.cobiss.net/cobiss/sr/sr/bib/1025216946
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12039
AB  - Kardiovaskularne bolesti (KVB) su vodeći zdravstveni problem širom sveta i predstavljaju vodeći uzrok smrtnog ishoda na globalnom nivou. U osnovi većine KVB leži hronična inflamatorna bolest zida arterijskih krvnih sudova, ateroskleroza, tokom koje postepeno i progresivno dolazi do zadebljanja zida arterija, stvaranja aterosklerotskog plaka, remodelovanja zida krvnog suda, opstrukcije lumena, uzrokujući na kraju poremećaj protoka krvi i otežano snabdevanje krvlju tj. hipoksiju ili infarkt organa. Galektin-3 (gal-3) je protein uključen u ključne biološke procese koji leže u osnovi ateroskleroze: inflamaciju, fibrozu i remodelovanje krvnih sudova i srca. Predmet i cilj ove doktorske disertacije bio je da se ispita potencijal gal-3 u aterosklerozi karotida i koronarnih arterija, na nivou primarne strukture gena (DNK), što do sada nije urađeno ni u jednoj studiji, kao i na nivou transkripcije gena za gal-3 (LGALS-3). Za analizu potencijalne asocijacije genskih varijanti haplotipskog bloka koji obuhvata LGALS-3 sa nastankom i progresijom ateroskleroze karotida i koronarnih arterija, izabrali smo tagovane genske varijante koje pokrivaju 82% varijabilnosti sekvence pomenutog haplotipskog bloka: rs4040064, rs11628437 i rs7159490; rs2274273, na osnovu rezultata studije asocijacije celokupnog genoma sa cirkulišućim vrednostima gal-3 u kojoj je identifikovana kao vodeća, statistički najznačajnije asocirana varijanta LGALS-3 lokusa; i rs17128183, kao potencijalno funkcionalnu varijantu na osnovu rezultata RegulomeDB baze podataka. U studiju su uključeni bolesnici sa aterosklerozom karotida (n=467) i bolesnici sa aterosklerozom koronarnih arterija (i prvim akutnim infarktom miokarda kao posledicom) (n=167), kao i zdravi pripadnici srpske populacije (n=297). Naši rezultati sugerišu da, iako odabrane genske varijante nisu asocirane sa nastankom ateroskleroze karotida i koronarnih arterija, jesu potencijalno funkcionalne varijante, utičući na nivo transkripcije LGALS-3 gena. Ove varijante su asocirane i sa razvojem maladaptivnog remodelovanja leve komore i srčane insuficijencije šest meseci nakon prvog akutnog infarkta mokarda. Na osnovu naših rezultata sugerišemo da su ispitivane genske varijante korisni markeri u proceni rizika za nastanak komplikacija nakon infarkta miokarda i progresiji bolesti koja može dovesti do srčane insuficijencije
AB  - Cardiovascular diseases (CVDs) are the major healthcare issue and the leading cause of death worldwide. The leading cause of most of the CVDs is chronic inflammatory disease of the arterial blood vessel wall, atherosclerosis, during which the arterial wall gradually and progressively thickens, atherosclerotic plaque forms, the arterial blood vessel wall remodels, lumen obstructs, causing in the end the disruption of blood flow and difficulties in blood supply, ie. hypoxia or organ infarction. Galectin-3 (gal-3) is a protein involved in the key biological processes that underlie atherosclerosis: inflammation, fibrosis and blood vessel and cardiac remodeling. The subject and the aim of this doctoral dissertation was to examine the gal-3 potential in carotid and coronary atherosclerosis at the level of DNA structure, which no one has done before, as well as at the LGALS-3 gene (gal-3 gene) transcription level. For the potential association analysis of genetic variants in the haplotype block containing LGALS-3 with development and progression of carotid and coronary atherosclerosis, we selected tag genetic variants that cover 82% of the sequence variability of the haplotype block containing LGALS-3: rs4040064, rs11628437 and rs7159490; rs2274273, based on the results of the GWAS of circulating gal-3 in which it was identified as the lead variant of LGALS-3 locus; and rs17128183, as potentially functional variant based on the results of the RegulomeDB database. The study included patients with carotid atherosclerosis (n=467), patients with coronary atherosclerosis (and the first acute myocardial infarction as a consequence) (n=167), as well as healthy members of the Serbian population (n=297). Our results suggest that, although selected genetic variants were not associated with the onset of carotid and coronary atherosclerosis, they are potentially functional variants, affecting the LGALS-3 transcription. Also, these variants were associated with the development of maladaptive left ventricular remodeling and heart failure six months after the first acute myocardial infarction. Based on our results, we suggest that the investigated genetic variants are useful markers in assessing the risk of complications following myocardial infarction and the progression of disease that can lead to heart failure.
PB  - Универзитет у Београду, Биолошки факултет
T2  - Универзитет у Београду
T1  - Molekularna karakterizacija i epidemiološka analiza haplotipskog bloka koji sadrži gen za galektin-3 u bolestima srca i krvnih sudova kod čoveka
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12039
ER  - 

@phdthesis{
author = "Đorđević, Ana M.",
year = "2019",
abstract = "Kardiovaskularne bolesti (KVB) su vodeći zdravstveni problem širom sveta i predstavljaju vodeći uzrok smrtnog ishoda na globalnom nivou. U osnovi većine KVB leži hronična inflamatorna bolest zida arterijskih krvnih sudova, ateroskleroza, tokom koje postepeno i progresivno dolazi do zadebljanja zida arterija, stvaranja aterosklerotskog plaka, remodelovanja zida krvnog suda, opstrukcije lumena, uzrokujući na kraju poremećaj protoka krvi i otežano snabdevanje krvlju tj. hipoksiju ili infarkt organa. Galektin-3 (gal-3) je protein uključen u ključne biološke procese koji leže u osnovi ateroskleroze: inflamaciju, fibrozu i remodelovanje krvnih sudova i srca. Predmet i cilj ove doktorske disertacije bio je da se ispita potencijal gal-3 u aterosklerozi karotida i koronarnih arterija, na nivou primarne strukture gena (DNK), što do sada nije urađeno ni u jednoj studiji, kao i na nivou transkripcije gena za gal-3 (LGALS-3). Za analizu potencijalne asocijacije genskih varijanti haplotipskog bloka koji obuhvata LGALS-3 sa nastankom i progresijom ateroskleroze karotida i koronarnih arterija, izabrali smo tagovane genske varijante koje pokrivaju 82% varijabilnosti sekvence pomenutog haplotipskog bloka: rs4040064, rs11628437 i rs7159490; rs2274273, na osnovu rezultata studije asocijacije celokupnog genoma sa cirkulišućim vrednostima gal-3 u kojoj je identifikovana kao vodeća, statistički najznačajnije asocirana varijanta LGALS-3 lokusa; i rs17128183, kao potencijalno funkcionalnu varijantu na osnovu rezultata RegulomeDB baze podataka. U studiju su uključeni bolesnici sa aterosklerozom karotida (n=467) i bolesnici sa aterosklerozom koronarnih arterija (i prvim akutnim infarktom miokarda kao posledicom) (n=167), kao i zdravi pripadnici srpske populacije (n=297). Naši rezultati sugerišu da, iako odabrane genske varijante nisu asocirane sa nastankom ateroskleroze karotida i koronarnih arterija, jesu potencijalno funkcionalne varijante, utičući na nivo transkripcije LGALS-3 gena. Ove varijante su asocirane i sa razvojem maladaptivnog remodelovanja leve komore i srčane insuficijencije šest meseci nakon prvog akutnog infarkta mokarda. Na osnovu naših rezultata sugerišemo da su ispitivane genske varijante korisni markeri u proceni rizika za nastanak komplikacija nakon infarkta miokarda i progresiji bolesti koja može dovesti do srčane insuficijencije, Cardiovascular diseases (CVDs) are the major healthcare issue and the leading cause of death worldwide. The leading cause of most of the CVDs is chronic inflammatory disease of the arterial blood vessel wall, atherosclerosis, during which the arterial wall gradually and progressively thickens, atherosclerotic plaque forms, the arterial blood vessel wall remodels, lumen obstructs, causing in the end the disruption of blood flow and difficulties in blood supply, ie. hypoxia or organ infarction. Galectin-3 (gal-3) is a protein involved in the key biological processes that underlie atherosclerosis: inflammation, fibrosis and blood vessel and cardiac remodeling. The subject and the aim of this doctoral dissertation was to examine the gal-3 potential in carotid and coronary atherosclerosis at the level of DNA structure, which no one has done before, as well as at the LGALS-3 gene (gal-3 gene) transcription level. For the potential association analysis of genetic variants in the haplotype block containing LGALS-3 with development and progression of carotid and coronary atherosclerosis, we selected tag genetic variants that cover 82% of the sequence variability of the haplotype block containing LGALS-3: rs4040064, rs11628437 and rs7159490; rs2274273, based on the results of the GWAS of circulating gal-3 in which it was identified as the lead variant of LGALS-3 locus; and rs17128183, as potentially functional variant based on the results of the RegulomeDB database. The study included patients with carotid atherosclerosis (n=467), patients with coronary atherosclerosis (and the first acute myocardial infarction as a consequence) (n=167), as well as healthy members of the Serbian population (n=297). Our results suggest that, although selected genetic variants were not associated with the onset of carotid and coronary atherosclerosis, they are potentially functional variants, affecting the LGALS-3 transcription. Also, these variants were associated with the development of maladaptive left ventricular remodeling and heart failure six months after the first acute myocardial infarction. Based on our results, we suggest that the investigated genetic variants are useful markers in assessing the risk of complications following myocardial infarction and the progression of disease that can lead to heart failure.",
publisher = "Универзитет у Београду, Биолошки факултет",
journal = "Универзитет у Београду",
title = "Molekularna karakterizacija i epidemiološka analiza haplotipskog bloka koji sadrži gen za galektin-3 u bolestima srca i krvnih sudova kod čoveka",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12039"
}

Đorđević, A. M.. (2019). Molekularna karakterizacija i epidemiološka analiza haplotipskog bloka koji sadrži gen za galektin-3 u bolestima srca i krvnih sudova kod čoveka. in Универзитет у Београду
Универзитет у Београду, Биолошки факултет..
https://hdl.handle.net/21.15107/rcub_vinar_12039

Đorđević AM. Molekularna karakterizacija i epidemiološka analiza haplotipskog bloka koji sadrži gen za galektin-3 u bolestima srca i krvnih sudova kod čoveka. in Универзитет у Београду. 2019;.
https://hdl.handle.net/21.15107/rcub_vinar_12039 .

Đorđević, Ana M., "Molekularna karakterizacija i epidemiološka analiza haplotipskog bloka koji sadrži gen za galektin-3 u bolestima srca i krvnih sudova kod čoveka" in Универзитет у Београду (2019),
https://hdl.handle.net/21.15107/rcub_vinar_12039 .

TY  - JOUR
AU  - Đorđević, Ana D.
AU  - Dekleva, Milica
AU  - Živković, Maja
AU  - Stanković, Aleksandra
AU  - Marković-Nikolić, Nataša
AU  - Alavantić, Dragan
AU  - Đurić, Tamara
PY  - 2018
UR  - http://link.springer.com/10.1007/s11033-018-4384-4
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7958
AB  - Post-infarct left ventricular remodeling (LVR) process increases the risk of heart failure (HF). Circulating galectin-3 has been associated with fibrosis, inflammation and cardiac dysfunction during the remodeling process after myocardial infarction (MI). The aims of this prospective case study were to investigate the association of potentially functional variants in the vicinity of LGALS-3 locus, rs2274273 and rs17128183 with maladaptive LVR and whether these variants could affect LGALS-3 mRNA expression in peripheral blood mononuclear cells of patients 6 months after the first MI. This study encompassed 167 patients with acute MI that were followed up for 6 months. Evidence of LVR was obtained by repeated 2D Doppler echocardiography. Rs2274273, rs17128183 and LGALS-3 mRNA expression were detected by TaqMan® technology. Rs2274273 and rs17128183 rare allele bearing genotypes, according to the dominant model (CT+TT vs. CC and AG+GG vs. AA, respectively), were significantly and independently associated with maladaptive LVR (adjusted OR = 3.02, P = 0.016; adjusted OR = 3.14, P = 0.019, respectively) and higher LGALS-3 mRNA expression (fold induction 1.203, P = 0.03 and 1.214, P = 0.03, respectively). Our exploratory results suggest that rs2274273 and rs17128183 variants affect LGALS-3 mRNA and bear the risk for maladaptive LVR post-MI remodeling. Further replication and validation in a larger group of patients is inevitable. © 2018, Springer Nature B.V.
T2  - Molecular Biology Reports
T1  - Left ventricular remodeling after the first myocardial infarction in association with LGALS-3 neighbouring variants rs2274273 and rs17128183 and its relative mRNA expression: a prospective study
VL  - 45
IS  - 6
SP  - 2227
EP  - 2236
DO  - 10.1007/s11033-018-4384-4
ER  - 

@article{
author = "Đorđević, Ana D. and Dekleva, Milica and Živković, Maja and Stanković, Aleksandra and Marković-Nikolić, Nataša and Alavantić, Dragan and Đurić, Tamara",
year = "2018",
abstract = "Post-infarct left ventricular remodeling (LVR) process increases the risk of heart failure (HF). Circulating galectin-3 has been associated with fibrosis, inflammation and cardiac dysfunction during the remodeling process after myocardial infarction (MI). The aims of this prospective case study were to investigate the association of potentially functional variants in the vicinity of LGALS-3 locus, rs2274273 and rs17128183 with maladaptive LVR and whether these variants could affect LGALS-3 mRNA expression in peripheral blood mononuclear cells of patients 6 months after the first MI. This study encompassed 167 patients with acute MI that were followed up for 6 months. Evidence of LVR was obtained by repeated 2D Doppler echocardiography. Rs2274273, rs17128183 and LGALS-3 mRNA expression were detected by TaqMan® technology. Rs2274273 and rs17128183 rare allele bearing genotypes, according to the dominant model (CT+TT vs. CC and AG+GG vs. AA, respectively), were significantly and independently associated with maladaptive LVR (adjusted OR = 3.02, P = 0.016; adjusted OR = 3.14, P = 0.019, respectively) and higher LGALS-3 mRNA expression (fold induction 1.203, P = 0.03 and 1.214, P = 0.03, respectively). Our exploratory results suggest that rs2274273 and rs17128183 variants affect LGALS-3 mRNA and bear the risk for maladaptive LVR post-MI remodeling. Further replication and validation in a larger group of patients is inevitable. © 2018, Springer Nature B.V.",
journal = "Molecular Biology Reports",
title = "Left ventricular remodeling after the first myocardial infarction in association with LGALS-3 neighbouring variants rs2274273 and rs17128183 and its relative mRNA expression: a prospective study",
volume = "45",
number = "6",
pages = "2227-2236",
doi = "10.1007/s11033-018-4384-4"
}

Đorđević, A. D., Dekleva, M., Živković, M., Stanković, A., Marković-Nikolić, N., Alavantić, D.,& Đurić, T.. (2018). Left ventricular remodeling after the first myocardial infarction in association with LGALS-3 neighbouring variants rs2274273 and rs17128183 and its relative mRNA expression: a prospective study. in Molecular Biology Reports, 45(6), 2227-2236.
https://doi.org/10.1007/s11033-018-4384-4

Đorđević AD, Dekleva M, Živković M, Stanković A, Marković-Nikolić N, Alavantić D, Đurić T. Left ventricular remodeling after the first myocardial infarction in association with LGALS-3 neighbouring variants rs2274273 and rs17128183 and its relative mRNA expression: a prospective study. in Molecular Biology Reports. 2018;45(6):2227-2236.
doi:10.1007/s11033-018-4384-4 .

Đorđević, Ana D., Dekleva, Milica, Živković, Maja, Stanković, Aleksandra, Marković-Nikolić, Nataša, Alavantić, Dragan, Đurić, Tamara, "Left ventricular remodeling after the first myocardial infarction in association with LGALS-3 neighbouring variants rs2274273 and rs17128183 and its relative mRNA expression: a prospective study" in Molecular Biology Reports, 45, no. 6 (2018):2227-2236,
https://doi.org/10.1007/s11033-018-4384-4 . .

TY  - CONF
AU  - Đorđević, Ana
AU  - Živković, Maja
AU  - Dekleva, Milica
AU  - Marković-Nikolić, Nataša
AU  - Alavantić, Dragan
AU  - Stanković, Aleksandra
AU  - Đurić, Tamara
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7177
C3  - Atherosclerosis
T1  - Snps in the Vicinity of Lgals-3 Locus and Different Shape-Types of Heart Remodeling After the First Myocardial Infarction: Preliminary Results
VL  - 263
SP  - E180
EP  - E180
DO  - 10.1016/j.atherosclerosis.2017.06.578
ER  - 

@conference{
author = "Đorđević, Ana and Živković, Maja and Dekleva, Milica and Marković-Nikolić, Nataša and Alavantić, Dragan and Stanković, Aleksandra and Đurić, Tamara",
year = "2017",
journal = "Atherosclerosis",
title = "Snps in the Vicinity of Lgals-3 Locus and Different Shape-Types of Heart Remodeling After the First Myocardial Infarction: Preliminary Results",
volume = "263",
pages = "E180-E180",
doi = "10.1016/j.atherosclerosis.2017.06.578"
}

Đorđević, A., Živković, M., Dekleva, M., Marković-Nikolić, N., Alavantić, D., Stanković, A.,& Đurić, T.. (2017). Snps in the Vicinity of Lgals-3 Locus and Different Shape-Types of Heart Remodeling After the First Myocardial Infarction: Preliminary Results. in Atherosclerosis, 263, E180-E180.
https://doi.org/10.1016/j.atherosclerosis.2017.06.578

Đorđević A, Živković M, Dekleva M, Marković-Nikolić N, Alavantić D, Stanković A, Đurić T. Snps in the Vicinity of Lgals-3 Locus and Different Shape-Types of Heart Remodeling After the First Myocardial Infarction: Preliminary Results. in Atherosclerosis. 2017;263:E180-E180.
doi:10.1016/j.atherosclerosis.2017.06.578 .

Đorđević, Ana, Živković, Maja, Dekleva, Milica, Marković-Nikolić, Nataša, Alavantić, Dragan, Stanković, Aleksandra, Đurić, Tamara, "Snps in the Vicinity of Lgals-3 Locus and Different Shape-Types of Heart Remodeling After the First Myocardial Infarction: Preliminary Results" in Atherosclerosis, 263 (2017):E180-E180,
https://doi.org/10.1016/j.atherosclerosis.2017.06.578 . .

TY  - CONF
AU  - Životić, Ivan
AU  - Živković, Maja
AU  - Đurić, Tamara
AU  - Stanković, Aleksandra
AU  - Đorđević, Ana
AU  - Dekleva, Milica
AU  - Marković-Nikolić, Nevena
AU  - Alavantić, Dragan
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7178
AB  - Aim: Myocardial infarction (MI) is the clinical complication predominately
caused by coronary plaque buildup and rupture during the process of
atherosclerosis. In the 9p21 locus two important risk haplotype blocks
have been identified. The one that carries the risk for MI with the lead
variant rs10757278 and another characterized to influence progression of
the MI, with the lead variant rs518394. We have investigated association of
the two genetic variants with the ST-elevated MI in the gender specific
manner. We have also tested variants effect on p15 mRNA level as one of
the possible mechanisms of the variants effect.Methods: The study group included 147 patients (72 females) with angiographically assessed MI, and 240 healthy controls (90 females). DNA
and RNA (n¼28) where isolated from peripheral blood mono nuclear
leukocytes. Genotypes for rs10757278 A/G and rs518394 C/G, and relative
mRNA level for p15 were determined using commercial TaqMan® assays
on 7500 ABI Real-Time PCR.
Results: We have found significant association of rs10757278 GG with STelevated MI occurrence, with OR of 2.2 (CI¼1.07-4.5, p¼0.03) in females.
P15 mRNA was significantly down-regulated in G allele carriers (AG+GG vs
AA) by a mean factor of 0.449 (S.E. range is 0.188-1.059), p¼0.019 in the
whole group. The genetic variant rs518394 was not significantly associated
either with MI or p15 mRNA level.
Conclusions: Genotype GG of rs10757278 is significantly associated with
MI occurrence in females in Serbian population. On
C3  - Atherosclerosis
T1  - RS10757278 from 9P21 is associated with st-elevated myocardial infarction in females in population of Serbia
VL  - 263
SP  - e188
EP  - e188
DO  - 10.1016/j.atherosclerosis.2017.06.603
ER  - 

@conference{
author = "Životić, Ivan and Živković, Maja and Đurić, Tamara and Stanković, Aleksandra and Đorđević, Ana and Dekleva, Milica and Marković-Nikolić, Nevena and Alavantić, Dragan",
year = "2017",
abstract = "Aim: Myocardial infarction (MI) is the clinical complication predominately
caused by coronary plaque buildup and rupture during the process of
atherosclerosis. In the 9p21 locus two important risk haplotype blocks
have been identified. The one that carries the risk for MI with the lead
variant rs10757278 and another characterized to influence progression of
the MI, with the lead variant rs518394. We have investigated association of
the two genetic variants with the ST-elevated MI in the gender specific
manner. We have also tested variants effect on p15 mRNA level as one of
the possible mechanisms of the variants effect.Methods: The study group included 147 patients (72 females) with angiographically assessed MI, and 240 healthy controls (90 females). DNA
and RNA (n¼28) where isolated from peripheral blood mono nuclear
leukocytes. Genotypes for rs10757278 A/G and rs518394 C/G, and relative
mRNA level for p15 were determined using commercial TaqMan® assays
on 7500 ABI Real-Time PCR.
Results: We have found significant association of rs10757278 GG with STelevated MI occurrence, with OR of 2.2 (CI¼1.07-4.5, p¼0.03) in females.
P15 mRNA was significantly down-regulated in G allele carriers (AG+GG vs
AA) by a mean factor of 0.449 (S.E. range is 0.188-1.059), p¼0.019 in the
whole group. The genetic variant rs518394 was not significantly associated
either with MI or p15 mRNA level.
Conclusions: Genotype GG of rs10757278 is significantly associated with
MI occurrence in females in Serbian population. On",
journal = "Atherosclerosis",
title = "RS10757278 from 9P21 is associated with st-elevated myocardial infarction in females in population of Serbia",
volume = "263",
pages = "e188-e188",
doi = "10.1016/j.atherosclerosis.2017.06.603"
}

Životić, I., Živković, M., Đurić, T., Stanković, A., Đorđević, A., Dekleva, M., Marković-Nikolić, N.,& Alavantić, D.. (2017). RS10757278 from 9P21 is associated with st-elevated myocardial infarction in females in population of Serbia. in Atherosclerosis, 263, e188-e188.
https://doi.org/10.1016/j.atherosclerosis.2017.06.603

Životić I, Živković M, Đurić T, Stanković A, Đorđević A, Dekleva M, Marković-Nikolić N, Alavantić D. RS10757278 from 9P21 is associated with st-elevated myocardial infarction in females in population of Serbia. in Atherosclerosis. 2017;263:e188-e188.
doi:10.1016/j.atherosclerosis.2017.06.603 .

Životić, Ivan, Živković, Maja, Đurić, Tamara, Stanković, Aleksandra, Đorđević, Ana, Dekleva, Milica, Marković-Nikolić, Nevena, Alavantić, Dragan, "RS10757278 from 9P21 is associated with st-elevated myocardial infarction in females in population of Serbia" in Atherosclerosis, 263 (2017):e188-e188,
https://doi.org/10.1016/j.atherosclerosis.2017.06.603 . .

TY  - CONF
AU  - Dekleva, Milica
AU  - Đorđević, Ana
AU  - Živković, Maja
AU  - Stanković, Aleksandra
AU  - Nikolic, N. M. Markovic
AU  - Đurić, Tamara
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1564
C3  - European Journal of Heart Failure
T1  - Heart failure development and rs2274273 in the vicinity of LGALS-3 locus, LGALS-3 relative mRNA expression in patients with first myocardial infarction
VL  - 19
IS  - SI
SP  - 552
EP  - 552
DO  - 10.1093/eurheartj/ehx493.P5296
ER  - 

@conference{
author = "Dekleva, Milica and Đorđević, Ana and Živković, Maja and Stanković, Aleksandra and Nikolic, N. M. Markovic and Đurić, Tamara",
year = "2017",
journal = "European Journal of Heart Failure",
title = "Heart failure development and rs2274273 in the vicinity of LGALS-3 locus, LGALS-3 relative mRNA expression in patients with first myocardial infarction",
volume = "19",
number = "SI",
pages = "552-552",
doi = "10.1093/eurheartj/ehx493.P5296"
}

Dekleva, M., Đorđević, A., Živković, M., Stanković, A., Nikolic, N. M. M.,& Đurić, T.. (2017). Heart failure development and rs2274273 in the vicinity of LGALS-3 locus, LGALS-3 relative mRNA expression in patients with first myocardial infarction. in European Journal of Heart Failure, 19(SI), 552-552.
https://doi.org/10.1093/eurheartj/ehx493.P5296

Dekleva M, Đorđević A, Živković M, Stanković A, Nikolic NMM, Đurić T. Heart failure development and rs2274273 in the vicinity of LGALS-3 locus, LGALS-3 relative mRNA expression in patients with first myocardial infarction. in European Journal of Heart Failure. 2017;19(SI):552-552.
doi:10.1093/eurheartj/ehx493.P5296 .

Dekleva, Milica, Đorđević, Ana, Živković, Maja, Stanković, Aleksandra, Nikolic, N. M. Markovic, Đurić, Tamara, "Heart failure development and rs2274273 in the vicinity of LGALS-3 locus, LGALS-3 relative mRNA expression in patients with first myocardial infarction" in European Journal of Heart Failure, 19, no. SI (2017):552-552,
https://doi.org/10.1093/eurheartj/ehx493.P5296 . .

TY  - JOUR
AU  - Životić, Ivan
AU  - Đurić, Tamara
AU  - Stanković, Aleksandra
AU  - Đorđević, Ana
AU  - Končar, Igor
AU  - Davidović, Lazar
AU  - Alavantić, Dragan
AU  - Živković, Maja
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1126
AB  - Single nucleotide polymorphisms from the chromosome locus 9p21 are reported to carry a risk for various cardiovascular diseases. One of the lead single nucleotide polymorphisms, rs10757278, was mostly investigated in association with coronary artery disease but rarely with carotid atherosclerosis. In this study, we aimed to analyze the association of rs10757278 A/G polymorphism with carotid plaque presence in advanced carotid atherosclerosis. The study included 803 participants, 486 patients with high-grade stenosis ( GT 70%) who were undergoing carotid endarterectomy and 317 controls from Serbian population. Genotypes were determined using the real-time polymerase chain reaction. According to the recessive model of inheritance, GG genotype was significantly and independently associated with carotid plaque in females only (odds ratio 2.42, CI = 1.20-4.90, P = 0.013). Odds ratio was adjusted for age, body mass index, hypertension, TC, LDLC, HDLC and TG, and P value was corrected for multiple comparisons. Our preliminary findings suggest a gender-specific association of rs10757278 polymorphism with carotid plaque. Further studies on larger sample and in genetically and environmentally similar populations are needed.
T2  - Experimental Biology and Medicine
T1  - 9p21 locus rs10757278 is associated with advanced carotid atherosclerosis in a gender-specific manner
VL  - 241
IS  - 11
SP  - 1210
EP  - 1216
DO  - 10.1177/1535370216636718
ER  - 

@article{
author = "Životić, Ivan and Đurić, Tamara and Stanković, Aleksandra and Đorđević, Ana and Končar, Igor and Davidović, Lazar and Alavantić, Dragan and Živković, Maja",
year = "2016",
abstract = "Single nucleotide polymorphisms from the chromosome locus 9p21 are reported to carry a risk for various cardiovascular diseases. One of the lead single nucleotide polymorphisms, rs10757278, was mostly investigated in association with coronary artery disease but rarely with carotid atherosclerosis. In this study, we aimed to analyze the association of rs10757278 A/G polymorphism with carotid plaque presence in advanced carotid atherosclerosis. The study included 803 participants, 486 patients with high-grade stenosis ( GT 70%) who were undergoing carotid endarterectomy and 317 controls from Serbian population. Genotypes were determined using the real-time polymerase chain reaction. According to the recessive model of inheritance, GG genotype was significantly and independently associated with carotid plaque in females only (odds ratio 2.42, CI = 1.20-4.90, P = 0.013). Odds ratio was adjusted for age, body mass index, hypertension, TC, LDLC, HDLC and TG, and P value was corrected for multiple comparisons. Our preliminary findings suggest a gender-specific association of rs10757278 polymorphism with carotid plaque. Further studies on larger sample and in genetically and environmentally similar populations are needed.",
journal = "Experimental Biology and Medicine",
title = "9p21 locus rs10757278 is associated with advanced carotid atherosclerosis in a gender-specific manner",
volume = "241",
number = "11",
pages = "1210-1216",
doi = "10.1177/1535370216636718"
}

Životić, I., Đurić, T., Stanković, A., Đorđević, A., Končar, I., Davidović, L., Alavantić, D.,& Živković, M.. (2016). 9p21 locus rs10757278 is associated with advanced carotid atherosclerosis in a gender-specific manner. in Experimental Biology and Medicine, 241(11), 1210-1216.
https://doi.org/10.1177/1535370216636718

Životić I, Đurić T, Stanković A, Đorđević A, Končar I, Davidović L, Alavantić D, Živković M. 9p21 locus rs10757278 is associated with advanced carotid atherosclerosis in a gender-specific manner. in Experimental Biology and Medicine. 2016;241(11):1210-1216.
doi:10.1177/1535370216636718 .

Životić, Ivan, Đurić, Tamara, Stanković, Aleksandra, Đorđević, Ana, Končar, Igor, Davidović, Lazar, Alavantić, Dragan, Živković, Maja, "9p21 locus rs10757278 is associated with advanced carotid atherosclerosis in a gender-specific manner" in Experimental Biology and Medicine, 241, no. 11 (2016):1210-1216,
https://doi.org/10.1177/1535370216636718 . .

TY  - JOUR
AU  - Đorđević, Ana
AU  - Živković, Maja
AU  - Stanković, Aleksandra
AU  - Životić, Ivan
AU  - Končar, Igor
AU  - Davidović, Lazar
AU  - Alavantić, Dragan
AU  - Đurić, Tamara
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1291
AB  - BackgroundPrevious research has shown that there is an association between galectin-3 (gal-3) protein and cardiovascular pathology. The aim of this study was to investigate the effects of rs2274273 and rs17128183 on genetic susceptibility to advanced carotid atherosclerosis (CA) and its complications. The rs2274273 has been singled out as the lead SNP of the haplotype block containing LGALS-3 (gal-3 gene) associated with gal-3 circulating levels, while rs17128183 constitutes a potentially functional SNP of the same hap-block. We further sought to determine whether these genetic variants have an impact on the expression of LGALS-3 mRNA in human carotid atherosclerotic plaque tissue. MethodsThe study encompassed 300 control subjects and 485 patients with advanced CA who had undergone carotid endarterectomy. Rs2274273, rs17128183, and LGALS-3 relative mRNA expression was detected by means of real-time PCR (TaqMan((R)) technology). ResultsThere were no statistically significant associations of the investigated genetic variants with susceptibility to advanced CA, nor did we find any associations in terms of ultrasonographically defined plaque phenotypes. The relative expression of LGALS-3 mRNA proved to be significantly higher in carriers of the rare alleles (P=0.039) for both genetic variants. ConclusionOur exploratory results suggest that while rs2274273 and rs17128183 bear no association with the risk of advanced CA or CA-related complications, these genetic variants are likely to affect LGALS-3 expression levels. In order to reach a definitive conclusion on the role played by rs2274273 and rs17128183 in advanced CA, our results should be further validated.
T2  - Journal of Clinical Laboratory Analysis
T1  - Genetic Variants in the Vicinity of LGALS-3 Gene and LGALS-3 mRNA Expression in Advanced Carotid Atherosclerosis: An Exploratory Study
VL  - 30
IS  - 6
SP  - 1150
EP  - 1157
DO  - 10.1002/jcla.21996
ER  - 

@article{
author = "Đorđević, Ana and Živković, Maja and Stanković, Aleksandra and Životić, Ivan and Končar, Igor and Davidović, Lazar and Alavantić, Dragan and Đurić, Tamara",
year = "2016",
abstract = "BackgroundPrevious research has shown that there is an association between galectin-3 (gal-3) protein and cardiovascular pathology. The aim of this study was to investigate the effects of rs2274273 and rs17128183 on genetic susceptibility to advanced carotid atherosclerosis (CA) and its complications. The rs2274273 has been singled out as the lead SNP of the haplotype block containing LGALS-3 (gal-3 gene) associated with gal-3 circulating levels, while rs17128183 constitutes a potentially functional SNP of the same hap-block. We further sought to determine whether these genetic variants have an impact on the expression of LGALS-3 mRNA in human carotid atherosclerotic plaque tissue. MethodsThe study encompassed 300 control subjects and 485 patients with advanced CA who had undergone carotid endarterectomy. Rs2274273, rs17128183, and LGALS-3 relative mRNA expression was detected by means of real-time PCR (TaqMan((R)) technology). ResultsThere were no statistically significant associations of the investigated genetic variants with susceptibility to advanced CA, nor did we find any associations in terms of ultrasonographically defined plaque phenotypes. The relative expression of LGALS-3 mRNA proved to be significantly higher in carriers of the rare alleles (P=0.039) for both genetic variants. ConclusionOur exploratory results suggest that while rs2274273 and rs17128183 bear no association with the risk of advanced CA or CA-related complications, these genetic variants are likely to affect LGALS-3 expression levels. In order to reach a definitive conclusion on the role played by rs2274273 and rs17128183 in advanced CA, our results should be further validated.",
journal = "Journal of Clinical Laboratory Analysis",
title = "Genetic Variants in the Vicinity of LGALS-3 Gene and LGALS-3 mRNA Expression in Advanced Carotid Atherosclerosis: An Exploratory Study",
volume = "30",
number = "6",
pages = "1150-1157",
doi = "10.1002/jcla.21996"
}

Đorđević, A., Živković, M., Stanković, A., Životić, I., Končar, I., Davidović, L., Alavantić, D.,& Đurić, T.. (2016). Genetic Variants in the Vicinity of LGALS-3 Gene and LGALS-3 mRNA Expression in Advanced Carotid Atherosclerosis: An Exploratory Study. in Journal of Clinical Laboratory Analysis, 30(6), 1150-1157.
https://doi.org/10.1002/jcla.21996

Đorđević A, Živković M, Stanković A, Životić I, Končar I, Davidović L, Alavantić D, Đurić T. Genetic Variants in the Vicinity of LGALS-3 Gene and LGALS-3 mRNA Expression in Advanced Carotid Atherosclerosis: An Exploratory Study. in Journal of Clinical Laboratory Analysis. 2016;30(6):1150-1157.
doi:10.1002/jcla.21996 .

Đorđević, Ana, Živković, Maja, Stanković, Aleksandra, Životić, Ivan, Končar, Igor, Davidović, Lazar, Alavantić, Dragan, Đurić, Tamara, "Genetic Variants in the Vicinity of LGALS-3 Gene and LGALS-3 mRNA Expression in Advanced Carotid Atherosclerosis: An Exploratory Study" in Journal of Clinical Laboratory Analysis, 30, no. 6 (2016):1150-1157,
https://doi.org/10.1002/jcla.21996 . .

TY  - CONF
AU  - Đorđević, Ana
AU  - Đurić, Tamara
AU  - Živković, Maja
AU  - Životić, Ivan
AU  - Dekleva, Milica
AU  - Marković-Nikolić, Nataša
AU  - Alavantić, Dragan
AU  - Stanković, Aleksandra
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1101
C3  - European Journal of Heart Failure
T1  - Rs2274273 from LGALS-3 locus and cardiac ventricular remodeling after first myocardial infarction: preliminary results
VL  - 18
IS  - SI
SP  - 283
EP  - 284
UR  - https://hdl.handle.net/21.15107/rcub_vinar_1101
ER  - 

@conference{
author = "Đorđević, Ana and Đurić, Tamara and Živković, Maja and Životić, Ivan and Dekleva, Milica and Marković-Nikolić, Nataša and Alavantić, Dragan and Stanković, Aleksandra",
year = "2016",
journal = "European Journal of Heart Failure",
title = "Rs2274273 from LGALS-3 locus and cardiac ventricular remodeling after first myocardial infarction: preliminary results",
volume = "18",
number = "SI",
pages = "283-284",
url = "https://hdl.handle.net/21.15107/rcub_vinar_1101"
}

Đorđević, A., Đurić, T., Živković, M., Životić, I., Dekleva, M., Marković-Nikolić, N., Alavantić, D.,& Stanković, A.. (2016). Rs2274273 from LGALS-3 locus and cardiac ventricular remodeling after first myocardial infarction: preliminary results. in European Journal of Heart Failure, 18(SI), 283-284.
https://hdl.handle.net/21.15107/rcub_vinar_1101

Đorđević A, Đurić T, Živković M, Životić I, Dekleva M, Marković-Nikolić N, Alavantić D, Stanković A. Rs2274273 from LGALS-3 locus and cardiac ventricular remodeling after first myocardial infarction: preliminary results. in European Journal of Heart Failure. 2016;18(SI):283-284.
https://hdl.handle.net/21.15107/rcub_vinar_1101 .

Đorđević, Ana, Đurić, Tamara, Živković, Maja, Životić, Ivan, Dekleva, Milica, Marković-Nikolić, Nataša, Alavantić, Dragan, Stanković, Aleksandra, "Rs2274273 from LGALS-3 locus and cardiac ventricular remodeling after first myocardial infarction: preliminary results" in European Journal of Heart Failure, 18, no. SI (2016):283-284,
https://hdl.handle.net/21.15107/rcub_vinar_1101 .

TY  - CONF
AU  - Životić, Ivan
AU  - Đorđević, Ana
AU  - Đurić, Tamara
AU  - Končar, Igor
AU  - Alavantić, Dragan
AU  - Stanković, Aleksandra
AU  - Živković, Maja
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12811
AB  - Genome wide association studies have recognized the 9p21 rs10757278 polymorphism as a significant independent genetic prognostic marker for coronary artery disease. The aim of this study was to explore possible association of the rs10757278 polymorphism with advanced carotid atherosclerosis (CA) in the population of Serbia. The study group included 147 controls and 428 patients consecutively admitted for carotid endarterectomy. 9p21 rs10757278 polymorphism was genotyped using TaqMan technology on 7500 ABI Real Time PCR. There was no significant association of this polymorphism and CA, either in study group overall or in males. The GG genotype, according to recessive model of inheritance (AA+AG vs. GG), was significantly associated with advanced CA in females only (OR=2.15, 95% CI 1.07- 4.29, p=0.03). Preliminary results in this study suggest that rs10757278 GG genotype might be a significant predictive sex-specific marker for advanced CA in the population of Serbia.
PB  - Belgrade : Serbian Physiological Society
C3  - V Congress of the Serbian Genetic Society : Book of abstracts
T1  - Polymorphism rs10757278 in 9p21 region is associated with severe carotid atherosclerosis in sex specific manner: Preliminary results
SP  - 56
EP  - 56
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12811
ER  - 

@conference{
author = "Životić, Ivan and Đorđević, Ana and Đurić, Tamara and Končar, Igor and Alavantić, Dragan and Stanković, Aleksandra and Živković, Maja",
year = "2014",
abstract = "Genome wide association studies have recognized the 9p21 rs10757278 polymorphism as a significant independent genetic prognostic marker for coronary artery disease. The aim of this study was to explore possible association of the rs10757278 polymorphism with advanced carotid atherosclerosis (CA) in the population of Serbia. The study group included 147 controls and 428 patients consecutively admitted for carotid endarterectomy. 9p21 rs10757278 polymorphism was genotyped using TaqMan technology on 7500 ABI Real Time PCR. There was no significant association of this polymorphism and CA, either in study group overall or in males. The GG genotype, according to recessive model of inheritance (AA+AG vs. GG), was significantly associated with advanced CA in females only (OR=2.15, 95% CI 1.07- 4.29, p=0.03). Preliminary results in this study suggest that rs10757278 GG genotype might be a significant predictive sex-specific marker for advanced CA in the population of Serbia.",
publisher = "Belgrade : Serbian Physiological Society",
journal = "V Congress of the Serbian Genetic Society : Book of abstracts",
title = "Polymorphism rs10757278 in 9p21 region is associated with severe carotid atherosclerosis in sex specific manner: Preliminary results",
pages = "56-56",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12811"
}

Životić, I., Đorđević, A., Đurić, T., Končar, I., Alavantić, D., Stanković, A.,& Živković, M.. (2014). Polymorphism rs10757278 in 9p21 region is associated with severe carotid atherosclerosis in sex specific manner: Preliminary results. in V Congress of the Serbian Genetic Society : Book of abstracts
Belgrade : Serbian Physiological Society., 56-56.
https://hdl.handle.net/21.15107/rcub_vinar_12811

Životić I, Đorđević A, Đurić T, Končar I, Alavantić D, Stanković A, Živković M. Polymorphism rs10757278 in 9p21 region is associated with severe carotid atherosclerosis in sex specific manner: Preliminary results. in V Congress of the Serbian Genetic Society : Book of abstracts. 2014;:56-56.
https://hdl.handle.net/21.15107/rcub_vinar_12811 .

Životić, Ivan, Đorđević, Ana, Đurić, Tamara, Končar, Igor, Alavantić, Dragan, Stanković, Aleksandra, Živković, Maja, "Polymorphism rs10757278 in 9p21 region is associated with severe carotid atherosclerosis in sex specific manner: Preliminary results" in V Congress of the Serbian Genetic Society : Book of abstracts (2014):56-56,
https://hdl.handle.net/21.15107/rcub_vinar_12811 .

TY  - CONF
AU  - Živković, Maja
AU  - Đurić, Tamara
AU  - Đorđević, Ana
AU  - Životić, Ivan
AU  - Končar, Igor
AU  - Davidović, Lazar
AU  - Alavantić, Dragan
AU  - Stanković, Aleksandra
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12814
PB  - European Atherosclerosis Society
C3  - 82nd Congress of the European Atherosclerosis Society (EAS 2014) : Book of abstracts
T1  - The 9p21 as a potential risk factor for cad comorbidity in advanced carotid atherosclerosis: preliminary study
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12814
ER  - 

@conference{
author = "Živković, Maja and Đurić, Tamara and Đorđević, Ana and Životić, Ivan and Končar, Igor and Davidović, Lazar and Alavantić, Dragan and Stanković, Aleksandra",
year = "2014",
publisher = "European Atherosclerosis Society",
journal = "82nd Congress of the European Atherosclerosis Society (EAS 2014) : Book of abstracts",
title = "The 9p21 as a potential risk factor for cad comorbidity in advanced carotid atherosclerosis: preliminary study",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12814"
}

Živković, M., Đurić, T., Đorđević, A., Životić, I., Končar, I., Davidović, L., Alavantić, D.,& Stanković, A.. (2014). The 9p21 as a potential risk factor for cad comorbidity in advanced carotid atherosclerosis: preliminary study. in 82nd Congress of the European Atherosclerosis Society (EAS 2014) : Book of abstracts
European Atherosclerosis Society..
https://hdl.handle.net/21.15107/rcub_vinar_12814

Živković M, Đurić T, Đorđević A, Životić I, Končar I, Davidović L, Alavantić D, Stanković A. The 9p21 as a potential risk factor for cad comorbidity in advanced carotid atherosclerosis: preliminary study. in 82nd Congress of the European Atherosclerosis Society (EAS 2014) : Book of abstracts. 2014;.
https://hdl.handle.net/21.15107/rcub_vinar_12814 .

Živković, Maja, Đurić, Tamara, Đorđević, Ana, Životić, Ivan, Končar, Igor, Davidović, Lazar, Alavantić, Dragan, Stanković, Aleksandra, "The 9p21 as a potential risk factor for cad comorbidity in advanced carotid atherosclerosis: preliminary study" in 82nd Congress of the European Atherosclerosis Society (EAS 2014) : Book of abstracts (2014),
https://hdl.handle.net/21.15107/rcub_vinar_12814 .

TY  - CONF
AU  - Đorđević, Ana
AU  - Đurić, Tamara
AU  - Živković, Maja
AU  - Životić, Ivan
AU  - Dekleva, Milica
AU  - Marković-Nikolić, N.
AU  - Stanković, Aleksandra
AU  - Alavantić, Dragan
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12806
PB  - Belgrade : Serbian Physiological Society
C3  - 3rd Congress of physiological sciences of Serbia "Molecular, cellular and integrative basis of health and disease: Transdisciplinary approach" : Abstract book
T1  - RS2274273 gene polymorphisms in the locus that harbours LGALS-3 gene and left ventricular remodeling after first myocardial infarction: preliminary results
SP  - 109
EP  - 109
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12806
ER  - 

@conference{
author = "Đorđević, Ana and Đurić, Tamara and Živković, Maja and Životić, Ivan and Dekleva, Milica and Marković-Nikolić, N. and Stanković, Aleksandra and Alavantić, Dragan",
year = "2014",
publisher = "Belgrade : Serbian Physiological Society",
journal = "3rd Congress of physiological sciences of Serbia "Molecular, cellular and integrative basis of health and disease: Transdisciplinary approach" : Abstract book",
title = "RS2274273 gene polymorphisms in the locus that harbours LGALS-3 gene and left ventricular remodeling after first myocardial infarction: preliminary results",
pages = "109-109",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12806"
}

Đorđević, A., Đurić, T., Živković, M., Životić, I., Dekleva, M., Marković-Nikolić, N., Stanković, A.,& Alavantić, D.. (2014). RS2274273 gene polymorphisms in the locus that harbours LGALS-3 gene and left ventricular remodeling after first myocardial infarction: preliminary results. in 3rd Congress of physiological sciences of Serbia "Molecular, cellular and integrative basis of health and disease: Transdisciplinary approach" : Abstract book
Belgrade : Serbian Physiological Society., 109-109.
https://hdl.handle.net/21.15107/rcub_vinar_12806

Đorđević A, Đurić T, Živković M, Životić I, Dekleva M, Marković-Nikolić N, Stanković A, Alavantić D. RS2274273 gene polymorphisms in the locus that harbours LGALS-3 gene and left ventricular remodeling after first myocardial infarction: preliminary results. in 3rd Congress of physiological sciences of Serbia "Molecular, cellular and integrative basis of health and disease: Transdisciplinary approach" : Abstract book. 2014;:109-109.
https://hdl.handle.net/21.15107/rcub_vinar_12806 .

Đorđević, Ana, Đurić, Tamara, Živković, Maja, Životić, Ivan, Dekleva, Milica, Marković-Nikolić, N., Stanković, Aleksandra, Alavantić, Dragan, "RS2274273 gene polymorphisms in the locus that harbours LGALS-3 gene and left ventricular remodeling after first myocardial infarction: preliminary results" in 3rd Congress of physiological sciences of Serbia "Molecular, cellular and integrative basis of health and disease: Transdisciplinary approach" : Abstract book (2014):109-109,
https://hdl.handle.net/21.15107/rcub_vinar_12806 .

TY  - CONF
AU  - Đorđević, Ana
AU  - Živković, Maja
AU  - Dekleva, Milica
AU  - Marković-Nikolić, N.
AU  - Kuveljić, Jovana
AU  - Stanković, Aleksandra
AU  - Đurić, Tamara
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12807
PB  - Belgrade : Serbian Physiological Society
C3  - 3rd Congress of physiological sciences of Serbia "Molecular, cellular and integrative basis of health and disease: Transdisciplinary approach" : Abstract book
T1  - Matrix metalloproteinase-1 and matrix metalloproteinase-3 promoter gene polumorphisms in left ventricular remodeling after first myocardial infarction: preliminary results
SP  - 110
EP  - 110
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12807
ER  - 

@conference{
author = "Đorđević, Ana and Živković, Maja and Dekleva, Milica and Marković-Nikolić, N. and Kuveljić, Jovana and Stanković, Aleksandra and Đurić, Tamara",
year = "2014",
publisher = "Belgrade : Serbian Physiological Society",
journal = "3rd Congress of physiological sciences of Serbia "Molecular, cellular and integrative basis of health and disease: Transdisciplinary approach" : Abstract book",
title = "Matrix metalloproteinase-1 and matrix metalloproteinase-3 promoter gene polumorphisms in left ventricular remodeling after first myocardial infarction: preliminary results",
pages = "110-110",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12807"
}

Đorđević, A., Živković, M., Dekleva, M., Marković-Nikolić, N., Kuveljić, J., Stanković, A.,& Đurić, T.. (2014). Matrix metalloproteinase-1 and matrix metalloproteinase-3 promoter gene polumorphisms in left ventricular remodeling after first myocardial infarction: preliminary results. in 3rd Congress of physiological sciences of Serbia "Molecular, cellular and integrative basis of health and disease: Transdisciplinary approach" : Abstract book
Belgrade : Serbian Physiological Society., 110-110.
https://hdl.handle.net/21.15107/rcub_vinar_12807

Đorđević A, Živković M, Dekleva M, Marković-Nikolić N, Kuveljić J, Stanković A, Đurić T. Matrix metalloproteinase-1 and matrix metalloproteinase-3 promoter gene polumorphisms in left ventricular remodeling after first myocardial infarction: preliminary results. in 3rd Congress of physiological sciences of Serbia "Molecular, cellular and integrative basis of health and disease: Transdisciplinary approach" : Abstract book. 2014;:110-110.
https://hdl.handle.net/21.15107/rcub_vinar_12807 .

Đorđević, Ana, Živković, Maja, Dekleva, Milica, Marković-Nikolić, N., Kuveljić, Jovana, Stanković, Aleksandra, Đurić, Tamara, "Matrix metalloproteinase-1 and matrix metalloproteinase-3 promoter gene polumorphisms in left ventricular remodeling after first myocardial infarction: preliminary results" in 3rd Congress of physiological sciences of Serbia "Molecular, cellular and integrative basis of health and disease: Transdisciplinary approach" : Abstract book (2014):110-110,
https://hdl.handle.net/21.15107/rcub_vinar_12807 .