TY  - JOUR
AU  - Todorović, Ana
AU  - Bobić, Katarina
AU  - Veljković, Filip
AU  - Pejić, Snežana
AU  - Glumac, Sofija
AU  - Stanković, Sanja
AU  - Milovanović, Tijana
AU  - Vukoje, Ivana
AU  - Nedeljković, Jovan
AU  - Radojević Škodrić, Sanja
AU  - Pajović, Snežana B.
AU  - Drakulić, Dunja
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13090
AB  - Nanoparticles (NPs), a distinct class of particles ranging in size from 1 to 100 nm, are one of the most promising technologies of the 21st century, and titanium dioxide NPs (TiO2 NPs) are among the most widely produced and used NPs globally. The increased application of TiO2 NPs raises concerns regarding their global safety and risks of exposure. Many animal studies have reported the accumulation of TiO2 NPs in female reproductive organs; however, evidence of the resultant toxicity remains ambiguous. Since the surface area and chemical modifications of NPs can significantly change their cytotoxicity, we aimed to compare the toxic effects of pristine TiO2 powder with surface-modified TiO2 powders with salicylic acid (TiO2/SA) and 5-aminosalicylic acid (TiO2/5-ASA) on the ovaries, oviducts, and uterus on the 14th day following acute oral treatment. The results, based on alterations in food and water intake, body mass, organ-to-body mass ratio, hormonal status, histological features of tissues of interest, and antioxidant parameters, suggest that the modification with 5-ASA can mitigate some of the observed toxic effects of TiO2 powder and encourage future investigations to create NPs that can potentially reduce the harmful effects of TiO2 NPs while preserving their positive impacts.
T2  - Antioxidants
T1  - Comparable Toxicity of Surface-Modified TiO2 Nanoparticles: An In Vivo Experimental Study on Reproductive Toxicity in Rats
VL  - 13
IS  - 2
SP  - 231
DO  - 10.3390/antiox13020231
ER  - 

@article{
author = "Todorović, Ana and Bobić, Katarina and Veljković, Filip and Pejić, Snežana and Glumac, Sofija and Stanković, Sanja and Milovanović, Tijana and Vukoje, Ivana and Nedeljković, Jovan and Radojević Škodrić, Sanja and Pajović, Snežana B. and Drakulić, Dunja",
year = "2024",
abstract = "Nanoparticles (NPs), a distinct class of particles ranging in size from 1 to 100 nm, are one of the most promising technologies of the 21st century, and titanium dioxide NPs (TiO2 NPs) are among the most widely produced and used NPs globally. The increased application of TiO2 NPs raises concerns regarding their global safety and risks of exposure. Many animal studies have reported the accumulation of TiO2 NPs in female reproductive organs; however, evidence of the resultant toxicity remains ambiguous. Since the surface area and chemical modifications of NPs can significantly change their cytotoxicity, we aimed to compare the toxic effects of pristine TiO2 powder with surface-modified TiO2 powders with salicylic acid (TiO2/SA) and 5-aminosalicylic acid (TiO2/5-ASA) on the ovaries, oviducts, and uterus on the 14th day following acute oral treatment. The results, based on alterations in food and water intake, body mass, organ-to-body mass ratio, hormonal status, histological features of tissues of interest, and antioxidant parameters, suggest that the modification with 5-ASA can mitigate some of the observed toxic effects of TiO2 powder and encourage future investigations to create NPs that can potentially reduce the harmful effects of TiO2 NPs while preserving their positive impacts.",
journal = "Antioxidants",
title = "Comparable Toxicity of Surface-Modified TiO2 Nanoparticles: An In Vivo Experimental Study on Reproductive Toxicity in Rats",
volume = "13",
number = "2",
pages = "231",
doi = "10.3390/antiox13020231"
}

Todorović, A., Bobić, K., Veljković, F., Pejić, S., Glumac, S., Stanković, S., Milovanović, T., Vukoje, I., Nedeljković, J., Radojević Škodrić, S., Pajović, S. B.,& Drakulić, D.. (2024). Comparable Toxicity of Surface-Modified TiO2 Nanoparticles: An In Vivo Experimental Study on Reproductive Toxicity in Rats. in Antioxidants, 13(2), 231.
https://doi.org/10.3390/antiox13020231

Todorović A, Bobić K, Veljković F, Pejić S, Glumac S, Stanković S, Milovanović T, Vukoje I, Nedeljković J, Radojević Škodrić S, Pajović SB, Drakulić D. Comparable Toxicity of Surface-Modified TiO2 Nanoparticles: An In Vivo Experimental Study on Reproductive Toxicity in Rats. in Antioxidants. 2024;13(2):231.
doi:10.3390/antiox13020231 .

Todorović, Ana, Bobić, Katarina, Veljković, Filip, Pejić, Snežana, Glumac, Sofija, Stanković, Sanja, Milovanović, Tijana, Vukoje, Ivana, Nedeljković, Jovan, Radojević Škodrić, Sanja, Pajović, Snežana B., Drakulić, Dunja, "Comparable Toxicity of Surface-Modified TiO2 Nanoparticles: An In Vivo Experimental Study on Reproductive Toxicity in Rats" in Antioxidants, 13, no. 2 (2024):231,
https://doi.org/10.3390/antiox13020231 . .

TY  - CONF
AU  - Bobić, Katarina
AU  - Todorović, Ana
AU  - Pejić, Snežana
AU  - Veljković, Filip
AU  - Pajović, Snežana
AU  - Nedeljković, Jovan
AU  - Drakulić, Dunja
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12810
AB  - Titanium dioxide nanoparticles (Ti02 NPs) are widely used in different cosmetic products, food additives and pharmaceuticals. Their accumulation within the body is associated with adverse health effects. Since animal studies indicate that their outcomes could be ameliorated by different modifications, we tested the impact of Ti02 NPs surface-modified with 5-aminosalicylic acid (Ti02/5-ASA NPs) in female adult Wistar rats. For the purpose of this experiment,14 days following the acute oral intake, the effects of commercially available Ti02 NPs and i02/5-ASA NPs were compared, using well defined methods, to assess the signs of acute toxicity (agitation, convulsion, and mortality) and neurological function (visual placing,
spontaneous activity, and pacing/circling) along with the levels of end products of lipid peroxidation (LPP) in eyes. Our results indicate that following the treatments, spontaneous activity was disturbed while mortality, convulsion and visual placing were unaltered. The modification decreased Ti02 NPs-induced
impairment of agitation and pacing/circling. The insight into biomolecules in the eyes, more precisely into a marker of oxidative stress (LPP), showed that it was decreased after treatment with Ti02/5-ASA NPs in comparison to Ti02 NPs, indicating that this type of modification might mitigate Ti02 NPs-induced oxidative stress. According to obtained results, even though the exact  mechanism of the actions is still unknown, the modification with 5-aminosalicylic acid alleviates toxic effects of commercially available Ti02 NPs.
PB  - Vienna : Young Scientist Association
C3  - 18th YSA PhD Symposium 2023 : Book of abstracts
T1  - Rat toxicity study of orally administrated titanium dioxide nanoparticles modified with 5-aminosalicylic acid
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12810
ER  - 

@conference{
author = "Bobić, Katarina and Todorović, Ana and Pejić, Snežana and Veljković, Filip and Pajović, Snežana and Nedeljković, Jovan and Drakulić, Dunja",
year = "2023",
abstract = "Titanium dioxide nanoparticles (Ti02 NPs) are widely used in different cosmetic products, food additives and pharmaceuticals. Their accumulation within the body is associated with adverse health effects. Since animal studies indicate that their outcomes could be ameliorated by different modifications, we tested the impact of Ti02 NPs surface-modified with 5-aminosalicylic acid (Ti02/5-ASA NPs) in female adult Wistar rats. For the purpose of this experiment,14 days following the acute oral intake, the effects of commercially available Ti02 NPs and i02/5-ASA NPs were compared, using well defined methods, to assess the signs of acute toxicity (agitation, convulsion, and mortality) and neurological function (visual placing,
spontaneous activity, and pacing/circling) along with the levels of end products of lipid peroxidation (LPP) in eyes. Our results indicate that following the treatments, spontaneous activity was disturbed while mortality, convulsion and visual placing were unaltered. The modification decreased Ti02 NPs-induced
impairment of agitation and pacing/circling. The insight into biomolecules in the eyes, more precisely into a marker of oxidative stress (LPP), showed that it was decreased after treatment with Ti02/5-ASA NPs in comparison to Ti02 NPs, indicating that this type of modification might mitigate Ti02 NPs-induced oxidative stress. According to obtained results, even though the exact  mechanism of the actions is still unknown, the modification with 5-aminosalicylic acid alleviates toxic effects of commercially available Ti02 NPs.",
publisher = "Vienna : Young Scientist Association",
journal = "18th YSA PhD Symposium 2023 : Book of abstracts",
title = "Rat toxicity study of orally administrated titanium dioxide nanoparticles modified with 5-aminosalicylic acid",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12810"
}

Bobić, K., Todorović, A., Pejić, S., Veljković, F., Pajović, S., Nedeljković, J.,& Drakulić, D.. (2023). Rat toxicity study of orally administrated titanium dioxide nanoparticles modified with 5-aminosalicylic acid. in 18th YSA PhD Symposium 2023 : Book of abstracts
Vienna : Young Scientist Association..
https://hdl.handle.net/21.15107/rcub_vinar_12810

Bobić K, Todorović A, Pejić S, Veljković F, Pajović S, Nedeljković J, Drakulić D. Rat toxicity study of orally administrated titanium dioxide nanoparticles modified with 5-aminosalicylic acid. in 18th YSA PhD Symposium 2023 : Book of abstracts. 2023;.
https://hdl.handle.net/21.15107/rcub_vinar_12810 .

Bobić, Katarina, Todorović, Ana, Pejić, Snežana, Veljković, Filip, Pajović, Snežana, Nedeljković, Jovan, Drakulić, Dunja, "Rat toxicity study of orally administrated titanium dioxide nanoparticles modified with 5-aminosalicylic acid" in 18th YSA PhD Symposium 2023 : Book of abstracts (2023),
https://hdl.handle.net/21.15107/rcub_vinar_12810 .

TY  - CONF
AU  - Spasojević-Tišma, V.
AU  - Jeremić, M.
AU  - Pejić, Snežana
AU  - Drakulić, Dunja R.
AU  - Stanković, S.
AU  - Košutić, D.
AU  - Todorović, Ana
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12865
AB  - BACKGROUND-AIM Differentiated thyroid cancer (DTC) is the most rapidly diagnosed cancer worldwide and the most frequent endocrinemalignancy, comprised of differentiated subtypes, specifically papillary and follicular thyroid cancer. Thyroidectomyis currently the preferred treatment for DTC. However, adjuvant therapy in the form of radioactive iodine (131I) is oftenadministered to reduce the risk of tumor recurrence and to facilitate future cancer surveillance. As 131I treatmentadditionally might upregulate oxidative stress regularly observed in thyroid cancer patients, the aim of our study wasto investigate the alterations in the levels of glutathione (GSH), superoxide anion (O2-), nitric oxide (NO) and activityof superoxide dismutase (SOD) in blood of DTC patients treated with 131I. METHODS All investigated parameters were determined with well-established spectrophotometric methods in blood samples ofthyroidectomized DTC patients obtained 0 (before), 3, 7 and 30 days after the 131I treatment. The treatment was orallyadministered once in the dose of 3.7 GBq. RESULTS Our results showed that, compared to the values before the therapy, SOD activity was significantly increased on the3th and 30th day after the 131I treatment alongwith the levels of GSH on 7th day. Other investigated oxidative stressindicators were unchanged. According to obtained data, in the blood of thyroidectomized DTC patients during the first30 days after the therapy, increased antioxidative capacity, reflected through upregulated SOD activity and GSH levels,might be sufficient to prevent the increase of O2- and NO and, in general, suppress the oxidative stress. CONCLUSIONS Our findings provide a better insight into individual antioxidant parameters fluctuations, thus contribute to a betterunderstanding of the redox mechanisms critical for 131I treatment outcomes, since an increase in the oxidative stressin the early stages of therapy can affect later health concerns and may represent a potential risk factor for cancerprogression in DTC patients.
PB  - Berlin ; Boston : Walter de Gruyter
C3  - Clinical chemistry and laboratory medicine
T1  - Oxidative Stress in Differentiated Thyroid Cancer Patients After Radioiodine Treatment
VL  - 61
IS  - Special Supplement
SP  - S1416
EP  - S1416
DO  - 10.1515/cclm-2023-7051
ER  - 

@conference{
author = "Spasojević-Tišma, V. and Jeremić, M. and Pejić, Snežana and Drakulić, Dunja R. and Stanković, S. and Košutić, D. and Todorović, Ana",
year = "2023",
abstract = "BACKGROUND-AIM Differentiated thyroid cancer (DTC) is the most rapidly diagnosed cancer worldwide and the most frequent endocrinemalignancy, comprised of differentiated subtypes, specifically papillary and follicular thyroid cancer. Thyroidectomyis currently the preferred treatment for DTC. However, adjuvant therapy in the form of radioactive iodine (131I) is oftenadministered to reduce the risk of tumor recurrence and to facilitate future cancer surveillance. As 131I treatmentadditionally might upregulate oxidative stress regularly observed in thyroid cancer patients, the aim of our study wasto investigate the alterations in the levels of glutathione (GSH), superoxide anion (O2-), nitric oxide (NO) and activityof superoxide dismutase (SOD) in blood of DTC patients treated with 131I. METHODS All investigated parameters were determined with well-established spectrophotometric methods in blood samples ofthyroidectomized DTC patients obtained 0 (before), 3, 7 and 30 days after the 131I treatment. The treatment was orallyadministered once in the dose of 3.7 GBq. RESULTS Our results showed that, compared to the values before the therapy, SOD activity was significantly increased on the3th and 30th day after the 131I treatment alongwith the levels of GSH on 7th day. Other investigated oxidative stressindicators were unchanged. According to obtained data, in the blood of thyroidectomized DTC patients during the first30 days after the therapy, increased antioxidative capacity, reflected through upregulated SOD activity and GSH levels,might be sufficient to prevent the increase of O2- and NO and, in general, suppress the oxidative stress. CONCLUSIONS Our findings provide a better insight into individual antioxidant parameters fluctuations, thus contribute to a betterunderstanding of the redox mechanisms critical for 131I treatment outcomes, since an increase in the oxidative stressin the early stages of therapy can affect later health concerns and may represent a potential risk factor for cancerprogression in DTC patients.",
publisher = "Berlin ; Boston : Walter de Gruyter",
journal = "Clinical chemistry and laboratory medicine",
title = "Oxidative Stress in Differentiated Thyroid Cancer Patients After Radioiodine Treatment",
volume = "61",
number = "Special Supplement",
pages = "S1416-S1416",
doi = "10.1515/cclm-2023-7051"
}

Spasojević-Tišma, V., Jeremić, M., Pejić, S., Drakulić, D. R., Stanković, S., Košutić, D.,& Todorović, A.. (2023). Oxidative Stress in Differentiated Thyroid Cancer Patients After Radioiodine Treatment. in Clinical chemistry and laboratory medicine
Berlin ; Boston : Walter de Gruyter., 61(Special Supplement), S1416-S1416.
https://doi.org/10.1515/cclm-2023-7051

Spasojević-Tišma V, Jeremić M, Pejić S, Drakulić DR, Stanković S, Košutić D, Todorović A. Oxidative Stress in Differentiated Thyroid Cancer Patients After Radioiodine Treatment. in Clinical chemistry and laboratory medicine. 2023;61(Special Supplement):S1416-S1416.
doi:10.1515/cclm-2023-7051 .

Spasojević-Tišma, V., Jeremić, M., Pejić, Snežana, Drakulić, Dunja R., Stanković, S., Košutić, D., Todorović, Ana, "Oxidative Stress in Differentiated Thyroid Cancer Patients After Radioiodine Treatment" in Clinical chemistry and laboratory medicine, 61, no. Special Supplement (2023):S1416-S1416,
https://doi.org/10.1515/cclm-2023-7051 . .

TY  - CONF
AU  - Tijanić, A.
AU  - Ristić, T.
AU  - Habach, T.
AU  - Milenković, B.
AU  - Drakulić, Dunja R.
AU  - Pejić, Snežana
AU  - Stanković, S.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12858
AB  - BACKGROUND-AIM Invasive mechanical ventilation (IMV) is frequently needed intervention in patients with severe COVID19. There areattempts to identify biomarkers that could be helpful in determining the best moment to intubate these patients.It is known that cost-effective hematological indices, easily calculated from a routine complete blood count (CBC),are useful in determining patient's inflammatory response to COVID-19. The aim of this study was to examine thehematologic indices value in patients with and without the need for IMV and a control group.METHODS A total of 274 COVID-19 patients (178 males/96 females, median age 65), hospitalized in temporary COVID-19 hospitalin Clinic for Pulmonology Diseases, University Clinical Centre of Serbia in Belgrade between November 18, 2020 toJanuary 15, 2021, were stratified as IMV (Group 1) (n = 24) or did not require invasive mechanical ventilation (Group2) (n = 250). The control group was consisted of 274 healthy individuals. CBC was determined at hospital admissionusing Sysmex XN-1000 (Sysmex Corporation, Kobe, Japan). Few hematologic indices were calculated, the neutrophil-to-lymphocyte ratio (NLR), the derived NLR (d-NLR), the neutrophil-to-platelet ratio (NPR), the platelet-to-lymphocyteratio (PLR), the lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII). RESULTS There was significant differences (p<0.001) in all hematological ratios between COVID-19 patients and the controlgroup. Patients in Group 1 had significantly higher values of NLR (7.1 (3.3-15.7) vs 4.3 (2.4-8.1), p = 0.011), dNLR (4.4(2.5-8.3) vs 2.8 (1.7-5.1), p = 0.013), NPR (0.03 (0.02-0.05) vs 0.02 (0.01-0.03), p = 0.001), compared to those in group 2.Conversely, the Group 1 had markedly decreased LMR (1.9 (1.1-3.3) vs 2.5 (1.8-3.7), p = 0.043), compared to the Group2. There was no significant difference in PLR and SII between these two groups (p >0.05). CONCLUSIONS Our study suggests that admission value of hematological indices NLR, dNLR, NPR have potential for use as auxiliaries in clinical decision-making regarding the need for IMV in COVID-19 patients.
PB  - Berlin ; Boston : Walter de Gruyter
C3  - Clinical chemistry and laboratory medicine
T1  - Initial Hematologic Indices in COVID-19 Patients With Invasive Mechanical Ventilation
VL  - 61
IS  - Special Supplement
SP  - S770
EP  - S770
DO  - 10.1515/cclm-2023-7041
ER  - 

@conference{
author = "Tijanić, A. and Ristić, T. and Habach, T. and Milenković, B. and Drakulić, Dunja R. and Pejić, Snežana and Stanković, S.",
year = "2023",
abstract = "BACKGROUND-AIM Invasive mechanical ventilation (IMV) is frequently needed intervention in patients with severe COVID19. There areattempts to identify biomarkers that could be helpful in determining the best moment to intubate these patients.It is known that cost-effective hematological indices, easily calculated from a routine complete blood count (CBC),are useful in determining patient's inflammatory response to COVID-19. The aim of this study was to examine thehematologic indices value in patients with and without the need for IMV and a control group.METHODS A total of 274 COVID-19 patients (178 males/96 females, median age 65), hospitalized in temporary COVID-19 hospitalin Clinic for Pulmonology Diseases, University Clinical Centre of Serbia in Belgrade between November 18, 2020 toJanuary 15, 2021, were stratified as IMV (Group 1) (n = 24) or did not require invasive mechanical ventilation (Group2) (n = 250). The control group was consisted of 274 healthy individuals. CBC was determined at hospital admissionusing Sysmex XN-1000 (Sysmex Corporation, Kobe, Japan). Few hematologic indices were calculated, the neutrophil-to-lymphocyte ratio (NLR), the derived NLR (d-NLR), the neutrophil-to-platelet ratio (NPR), the platelet-to-lymphocyteratio (PLR), the lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII). RESULTS There was significant differences (p<0.001) in all hematological ratios between COVID-19 patients and the controlgroup. Patients in Group 1 had significantly higher values of NLR (7.1 (3.3-15.7) vs 4.3 (2.4-8.1), p = 0.011), dNLR (4.4(2.5-8.3) vs 2.8 (1.7-5.1), p = 0.013), NPR (0.03 (0.02-0.05) vs 0.02 (0.01-0.03), p = 0.001), compared to those in group 2.Conversely, the Group 1 had markedly decreased LMR (1.9 (1.1-3.3) vs 2.5 (1.8-3.7), p = 0.043), compared to the Group2. There was no significant difference in PLR and SII between these two groups (p >0.05). CONCLUSIONS Our study suggests that admission value of hematological indices NLR, dNLR, NPR have potential for use as auxiliaries in clinical decision-making regarding the need for IMV in COVID-19 patients.",
publisher = "Berlin ; Boston : Walter de Gruyter",
journal = "Clinical chemistry and laboratory medicine",
title = "Initial Hematologic Indices in COVID-19 Patients With Invasive Mechanical Ventilation",
volume = "61",
number = "Special Supplement",
pages = "S770-S770",
doi = "10.1515/cclm-2023-7041"
}

Tijanić, A., Ristić, T., Habach, T., Milenković, B., Drakulić, D. R., Pejić, S.,& Stanković, S.. (2023). Initial Hematologic Indices in COVID-19 Patients With Invasive Mechanical Ventilation. in Clinical chemistry and laboratory medicine
Berlin ; Boston : Walter de Gruyter., 61(Special Supplement), S770-S770.
https://doi.org/10.1515/cclm-2023-7041

Tijanić A, Ristić T, Habach T, Milenković B, Drakulić DR, Pejić S, Stanković S. Initial Hematologic Indices in COVID-19 Patients With Invasive Mechanical Ventilation. in Clinical chemistry and laboratory medicine. 2023;61(Special Supplement):S770-S770.
doi:10.1515/cclm-2023-7041 .

Tijanić, A., Ristić, T., Habach, T., Milenković, B., Drakulić, Dunja R., Pejić, Snežana, Stanković, S., "Initial Hematologic Indices in COVID-19 Patients With Invasive Mechanical Ventilation" in Clinical chemistry and laboratory medicine, 61, no. Special Supplement (2023):S770-S770,
https://doi.org/10.1515/cclm-2023-7041 . .

TY  - CONF
AU  - Bobić, Katarina
AU  - Guševac Stojanović, Ivana
AU  - Todorović, Ana
AU  - Veljković, Filip
AU  - Pejić, Snežana
AU  - Martinović, Jelena
AU  - Drakulić, Dunja
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11060
AB  - Prolonged disturbance of cerebral blood flow causes metabolic insufficiency and neuronal hypofunction, for which there is still no adequate therapeutic strategy. In several animal models of neurodegenerative diseases, progesterone (P4), a potent gonadal steroid hormone, and its metabolites showed neuroprotective outcomes through reduction of oxidative stress and stabilization of membrane lipids and their downstream signalling. As P4 actions in rat striatum following permanent bilateral occlusion of both common carotid arteries are still uncertain, we investigated its capacity to reduce neuronal damage induced by permanent occlusion of both carotid arteries (2VO), focusing on several oxidative stress markers (end products of lipid peroxidation (LPP) and phosphatidylcholine (PC) to lysophosphatidylcholine (LPC) intensity ratio) in crude synaptosomal fraction. Adult male Wistar rats were divided into groups: control ‒ sham operated animals treated with vehicle (commercial flax oil, 1 mg/kg) and permanently occluded animals subjected to either vehicle (commercial flax oil, 1 mg/kg) or P4 (dissolved in commercial flax oil, 1.7 mg/kg). Animals were subcutaneously injected for 7 days and sacrificed 4 h following the last treatment. LPP levels were determined spectrophotometrically, while PC/LPC intensity ratio was estimated by mass spectrometer. Obtained results indicate that P4 treatment alleviates 2VO – induced prooxidative changes by decreasing LPP levels and elevating PC/LPC intensity ratio, and returning them closer to levels observed in controls. According to our findings, P4 treatment in cerebral hypoperfusion model, via targeting striatal cell lipid components and altering lipid profile, might be implicated in reduction of oxidative stress and promotion of protective environment.
PB  - Belgrade : Serbian Neurocardiological Society
C3  - 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade
T1  - Progesterone modulates striatal lipid profile in rat cerebral hypoperfusion model
SP  - 119
EP  - 119
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11060
ER  - 

@conference{
author = "Bobić, Katarina and Guševac Stojanović, Ivana and Todorović, Ana and Veljković, Filip and Pejić, Snežana and Martinović, Jelena and Drakulić, Dunja",
year = "2023",
abstract = "Prolonged disturbance of cerebral blood flow causes metabolic insufficiency and neuronal hypofunction, for which there is still no adequate therapeutic strategy. In several animal models of neurodegenerative diseases, progesterone (P4), a potent gonadal steroid hormone, and its metabolites showed neuroprotective outcomes through reduction of oxidative stress and stabilization of membrane lipids and their downstream signalling. As P4 actions in rat striatum following permanent bilateral occlusion of both common carotid arteries are still uncertain, we investigated its capacity to reduce neuronal damage induced by permanent occlusion of both carotid arteries (2VO), focusing on several oxidative stress markers (end products of lipid peroxidation (LPP) and phosphatidylcholine (PC) to lysophosphatidylcholine (LPC) intensity ratio) in crude synaptosomal fraction. Adult male Wistar rats were divided into groups: control ‒ sham operated animals treated with vehicle (commercial flax oil, 1 mg/kg) and permanently occluded animals subjected to either vehicle (commercial flax oil, 1 mg/kg) or P4 (dissolved in commercial flax oil, 1.7 mg/kg). Animals were subcutaneously injected for 7 days and sacrificed 4 h following the last treatment. LPP levels were determined spectrophotometrically, while PC/LPC intensity ratio was estimated by mass spectrometer. Obtained results indicate that P4 treatment alleviates 2VO – induced prooxidative changes by decreasing LPP levels and elevating PC/LPC intensity ratio, and returning them closer to levels observed in controls. According to our findings, P4 treatment in cerebral hypoperfusion model, via targeting striatal cell lipid components and altering lipid profile, might be implicated in reduction of oxidative stress and promotion of protective environment.",
publisher = "Belgrade : Serbian Neurocardiological Society",
journal = "8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade",
title = "Progesterone modulates striatal lipid profile in rat cerebral hypoperfusion model",
pages = "119-119",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11060"
}

Bobić, K., Guševac Stojanović, I., Todorović, A., Veljković, F., Pejić, S., Martinović, J.,& Drakulić, D.. (2023). Progesterone modulates striatal lipid profile in rat cerebral hypoperfusion model. in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade
Belgrade : Serbian Neurocardiological Society., 119-119.
https://hdl.handle.net/21.15107/rcub_vinar_11060

Bobić K, Guševac Stojanović I, Todorović A, Veljković F, Pejić S, Martinović J, Drakulić D. Progesterone modulates striatal lipid profile in rat cerebral hypoperfusion model. in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade. 2023;:119-119.
https://hdl.handle.net/21.15107/rcub_vinar_11060 .

Bobić, Katarina, Guševac Stojanović, Ivana, Todorović, Ana, Veljković, Filip, Pejić, Snežana, Martinović, Jelena, Drakulić, Dunja, "Progesterone modulates striatal lipid profile in rat cerebral hypoperfusion model" in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade (2023):119-119,
https://hdl.handle.net/21.15107/rcub_vinar_11060 .

TY  - JOUR
AU  - Grigorov, Ilijana
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Drakulić, Dunja
AU  - Veljković, Filip
AU  - Miletić Vukajlović, Jadranka
AU  - Bobić, Katarina
AU  - Soldatović, Ivan
AU  - Đurašević, Siniša
AU  - Jasnić, Nebojša
AU  - Stanković, Sanja
AU  - Glumac, Sofija
AU  - Mihailović-Vučinić, Violeta
AU  - Milenković, Branislava
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11550
AB  - The careful monitoring of patients with mild/moderate COVID-19 is of particular importance because of the rapid progression of complications associated with COVID-19. For prognostic reasons and for the economic management of health care resources, additional biomarkers need to be identified, and their monitoring can conceivably be performed in the early stages of the disease. In this retrospective cross-sectional study, we found that serum concentrations of high-mobility group box 1 (HMGB1) and heme oxygenase-1 (HO-1), at the time of hospital admission, could be useful biomarkers for COVID-19 management. The study included 160 randomly selected recovered patients with mild to moderate COVID-19 on admission. Compared with healthy controls, serum HMGB1 and HO-1 levels increased by 487.6 pg/mL versus 43.1 pg/mL and 1497.7 pg/mL versus 756.1 pg/mL, respectively. Serum HO-1 correlated significantly with serum HMGB1, oxidative stress parameters (malondialdehyde (MDA), the phosphatidylcholine/lysophosphatidylcholine ratio (PC/LPC), the ratio of reduced and oxidative glutathione (GSH/GSSG)), and anti-inflammatory acute phase proteins (ferritin, haptoglobin). Increased heme catabolism/hemolysis were not detected. We hypothesize that the increase in HO-1 in the early phase of COVID-19 disease is likely to have a survival benefit by providing protection against oxidative stress and inflammation, whereas the level of HMGB1 increase reflects the activity of the innate immune system and represents levels within which the disease can be kept under control.
T2  - International Journal of Molecular Sciences
T1  - Serum High-Mobility Group Box 1 and Heme Oxygenase-1 as Biomarkers in COVID-19 Patients at Hospital Admission
VL  - 24
IS  - 17
SP  - 13164
DO  - 10.3390/ijms241713164
ER  - 

@article{
author = "Grigorov, Ilijana and Pejić, Snežana and Todorović, Ana and Drakulić, Dunja and Veljković, Filip and Miletić Vukajlović, Jadranka and Bobić, Katarina and Soldatović, Ivan and Đurašević, Siniša and Jasnić, Nebojša and Stanković, Sanja and Glumac, Sofija and Mihailović-Vučinić, Violeta and Milenković, Branislava",
year = "2023",
abstract = "The careful monitoring of patients with mild/moderate COVID-19 is of particular importance because of the rapid progression of complications associated with COVID-19. For prognostic reasons and for the economic management of health care resources, additional biomarkers need to be identified, and their monitoring can conceivably be performed in the early stages of the disease. In this retrospective cross-sectional study, we found that serum concentrations of high-mobility group box 1 (HMGB1) and heme oxygenase-1 (HO-1), at the time of hospital admission, could be useful biomarkers for COVID-19 management. The study included 160 randomly selected recovered patients with mild to moderate COVID-19 on admission. Compared with healthy controls, serum HMGB1 and HO-1 levels increased by 487.6 pg/mL versus 43.1 pg/mL and 1497.7 pg/mL versus 756.1 pg/mL, respectively. Serum HO-1 correlated significantly with serum HMGB1, oxidative stress parameters (malondialdehyde (MDA), the phosphatidylcholine/lysophosphatidylcholine ratio (PC/LPC), the ratio of reduced and oxidative glutathione (GSH/GSSG)), and anti-inflammatory acute phase proteins (ferritin, haptoglobin). Increased heme catabolism/hemolysis were not detected. We hypothesize that the increase in HO-1 in the early phase of COVID-19 disease is likely to have a survival benefit by providing protection against oxidative stress and inflammation, whereas the level of HMGB1 increase reflects the activity of the innate immune system and represents levels within which the disease can be kept under control.",
journal = "International Journal of Molecular Sciences",
title = "Serum High-Mobility Group Box 1 and Heme Oxygenase-1 as Biomarkers in COVID-19 Patients at Hospital Admission",
volume = "24",
number = "17",
pages = "13164",
doi = "10.3390/ijms241713164"
}

Grigorov, I., Pejić, S., Todorović, A., Drakulić, D., Veljković, F., Miletić Vukajlović, J., Bobić, K., Soldatović, I., Đurašević, S., Jasnić, N., Stanković, S., Glumac, S., Mihailović-Vučinić, V.,& Milenković, B.. (2023). Serum High-Mobility Group Box 1 and Heme Oxygenase-1 as Biomarkers in COVID-19 Patients at Hospital Admission. in International Journal of Molecular Sciences, 24(17), 13164.
https://doi.org/10.3390/ijms241713164

Grigorov I, Pejić S, Todorović A, Drakulić D, Veljković F, Miletić Vukajlović J, Bobić K, Soldatović I, Đurašević S, Jasnić N, Stanković S, Glumac S, Mihailović-Vučinić V, Milenković B. Serum High-Mobility Group Box 1 and Heme Oxygenase-1 as Biomarkers in COVID-19 Patients at Hospital Admission. in International Journal of Molecular Sciences. 2023;24(17):13164.
doi:10.3390/ijms241713164 .

Grigorov, Ilijana, Pejić, Snežana, Todorović, Ana, Drakulić, Dunja, Veljković, Filip, Miletić Vukajlović, Jadranka, Bobić, Katarina, Soldatović, Ivan, Đurašević, Siniša, Jasnić, Nebojša, Stanković, Sanja, Glumac, Sofija, Mihailović-Vučinić, Violeta, Milenković, Branislava, "Serum High-Mobility Group Box 1 and Heme Oxygenase-1 as Biomarkers in COVID-19 Patients at Hospital Admission" in International Journal of Molecular Sciences, 24, no. 17 (2023):13164,
https://doi.org/10.3390/ijms241713164 . .

TY  - CONF
AU  - Veljković, Filip
AU  - Drakulić, Dunja
AU  - Todorović, Ana
AU  - Pejić, Snežana
AU  - Bobić, Katarina
AU  - Stajčić, Ivana
AU  - Pajović, Snežana
AU  - Veličković, Suzana
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12663
AB  - It is known that the “superalkali” cluster Li2F can significantly improve the hydrogen storage capabilities in carbon materials; boron compounds play a similar role. However, the possibility of interactions of lithium fluoride clusters with boron and hydrogen has not been investigated so far. In this work, a laser desorption/ionization mass spectrometry (LDI MS) was used for this purpose. Preliminary results showed that the interaction between the “superalkali” Li3F cluster, boron and six hydrogen atoms is possible; the ion Li3FBH6+ was detected. Non-stoichiometric clusters of lithium fluoride can also combine with boron and hydrogen in the following manner: Li5F2BH5+ Li5F3BH2+ Li4F5BH4+ Li6F2B6H+, and Li8F6H+.
PB  - Kragujevac : Institute for Information Technologies, University of Kragujevac
C3  - ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings
T1  - Investigation of the possibility of interaction between lithium fluoride clusters and boron using LDI MS
SP  - 176
EP  - 179
DO  - 10.46793/ICCBI23.176V
ER  - 

@conference{
author = "Veljković, Filip and Drakulić, Dunja and Todorović, Ana and Pejić, Snežana and Bobić, Katarina and Stajčić, Ivana and Pajović, Snežana and Veličković, Suzana",
year = "2023",
abstract = "It is known that the “superalkali” cluster Li2F can significantly improve the hydrogen storage capabilities in carbon materials; boron compounds play a similar role. However, the possibility of interactions of lithium fluoride clusters with boron and hydrogen has not been investigated so far. In this work, a laser desorption/ionization mass spectrometry (LDI MS) was used for this purpose. Preliminary results showed that the interaction between the “superalkali” Li3F cluster, boron and six hydrogen atoms is possible; the ion Li3FBH6+ was detected. Non-stoichiometric clusters of lithium fluoride can also combine with boron and hydrogen in the following manner: Li5F2BH5+ Li5F3BH2+ Li4F5BH4+ Li6F2B6H+, and Li8F6H+.",
publisher = "Kragujevac : Institute for Information Technologies, University of Kragujevac",
journal = "ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings",
title = "Investigation of the possibility of interaction between lithium fluoride clusters and boron using LDI MS",
pages = "176-179",
doi = "10.46793/ICCBI23.176V"
}

Veljković, F., Drakulić, D., Todorović, A., Pejić, S., Bobić, K., Stajčić, I., Pajović, S.,& Veličković, S.. (2023). Investigation of the possibility of interaction between lithium fluoride clusters and boron using LDI MS. in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings
Kragujevac : Institute for Information Technologies, University of Kragujevac., 176-179.
https://doi.org/10.46793/ICCBI23.176V

Veljković F, Drakulić D, Todorović A, Pejić S, Bobić K, Stajčić I, Pajović S, Veličković S. Investigation of the possibility of interaction between lithium fluoride clusters and boron using LDI MS. in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings. 2023;:176-179.
doi:10.46793/ICCBI23.176V .

Veljković, Filip, Drakulić, Dunja, Todorović, Ana, Pejić, Snežana, Bobić, Katarina, Stajčić, Ivana, Pajović, Snežana, Veličković, Suzana, "Investigation of the possibility of interaction between lithium fluoride clusters and boron using LDI MS" in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings (2023):176-179,
https://doi.org/10.46793/ICCBI23.176V . .

TY  - CONF
AU  - Bobić, Katarina
AU  - Todorović, Ana
AU  - Pejić, Snežana
AU  - Veljković, Filip
AU  - Veličković, Suzana
AU  - Pajović, Snežana B.
AU  - Drakulić, Dunja
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12389
AB  - Titanium dioxide nanoparticles (TiO2NPs) are widely used in pharmaceutics, food products and cosmetics. Besides numerous beneficial outcomes, they also induce toxic effects in different organs, including the eyes. The recent findings report that some surface modifications can attenuate TiO2NPs toxicity. Thus, the aim of this study was to compare the effects of acute oral treatment with commercially available, bare TiO2NPs and TiO2NPs surface modified with salicylic acid (SA-TiO2NPs) using adult Wistar rats as model organisms. Control animals were gastrically intubated with vehicle (0.01 M HCl), while others were treated with either TiO2NPs or SA-TiO2NPs (1000mg/kg dissolved in vehicle). Afterward, the mortality rate as the acute toxicity parameter and parameters of neurological function were assessed. Animals were sacrificed on the 14th day following treatment. In the eye crude synaptosomal fraction, the effects of treatments on oxidative stress markers such as prooxidant/antioxidant balance (PAB) and lipid peroxidation (LPO) were compared. According to the obtained results, the mortality was 0 in all experimental groups. TiO2NPs and SA-TiO2NPs treatments displayed mild effects on spontaneous activity and pacing and had no impact on the visual placing reflex. Moreover, TiO2NPs and SA-TiO2NPs exposure significantly elevated PAB levels, when compared to controls. Animals treated with SA-TiO2NPs had similar LPO levels as controls, while in TiO2NPs group LPO levels were significantly increased. The presented data showed that both examined nanoparticles exerted similar outcomes referring to most of the investigated parameters, however, surface binding of SA decreased the level of LPO and thus, mitigated some of TiO2NPs toxicity in the eyes.
PB  - Kragujevac : Institute for Information Technologies, University of Kragujevac
C3  - ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings
T1  - TiO2 nanoparticles and TiO2 nanoparticles surface modified with salicylic acid affect neurological functions and oxidative stress markers in the eyes of adult rats
SP  - 499
EP  - 502
DO  - 10.46793/ICCBI23.499B
ER  - 

@conference{
author = "Bobić, Katarina and Todorović, Ana and Pejić, Snežana and Veljković, Filip and Veličković, Suzana and Pajović, Snežana B. and Drakulić, Dunja",
year = "2023",
abstract = "Titanium dioxide nanoparticles (TiO2NPs) are widely used in pharmaceutics, food products and cosmetics. Besides numerous beneficial outcomes, they also induce toxic effects in different organs, including the eyes. The recent findings report that some surface modifications can attenuate TiO2NPs toxicity. Thus, the aim of this study was to compare the effects of acute oral treatment with commercially available, bare TiO2NPs and TiO2NPs surface modified with salicylic acid (SA-TiO2NPs) using adult Wistar rats as model organisms. Control animals were gastrically intubated with vehicle (0.01 M HCl), while others were treated with either TiO2NPs or SA-TiO2NPs (1000mg/kg dissolved in vehicle). Afterward, the mortality rate as the acute toxicity parameter and parameters of neurological function were assessed. Animals were sacrificed on the 14th day following treatment. In the eye crude synaptosomal fraction, the effects of treatments on oxidative stress markers such as prooxidant/antioxidant balance (PAB) and lipid peroxidation (LPO) were compared. According to the obtained results, the mortality was 0 in all experimental groups. TiO2NPs and SA-TiO2NPs treatments displayed mild effects on spontaneous activity and pacing and had no impact on the visual placing reflex. Moreover, TiO2NPs and SA-TiO2NPs exposure significantly elevated PAB levels, when compared to controls. Animals treated with SA-TiO2NPs had similar LPO levels as controls, while in TiO2NPs group LPO levels were significantly increased. The presented data showed that both examined nanoparticles exerted similar outcomes referring to most of the investigated parameters, however, surface binding of SA decreased the level of LPO and thus, mitigated some of TiO2NPs toxicity in the eyes.",
publisher = "Kragujevac : Institute for Information Technologies, University of Kragujevac",
journal = "ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings",
title = "TiO2 nanoparticles and TiO2 nanoparticles surface modified with salicylic acid affect neurological functions and oxidative stress markers in the eyes of adult rats",
pages = "499-502",
doi = "10.46793/ICCBI23.499B"
}

Bobić, K., Todorović, A., Pejić, S., Veljković, F., Veličković, S., Pajović, S. B.,& Drakulić, D.. (2023). TiO2 nanoparticles and TiO2 nanoparticles surface modified with salicylic acid affect neurological functions and oxidative stress markers in the eyes of adult rats. in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings
Kragujevac : Institute for Information Technologies, University of Kragujevac., 499-502.
https://doi.org/10.46793/ICCBI23.499B

Bobić K, Todorović A, Pejić S, Veljković F, Veličković S, Pajović SB, Drakulić D. TiO2 nanoparticles and TiO2 nanoparticles surface modified with salicylic acid affect neurological functions and oxidative stress markers in the eyes of adult rats. in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings. 2023;:499-502.
doi:10.46793/ICCBI23.499B .

Bobić, Katarina, Todorović, Ana, Pejić, Snežana, Veljković, Filip, Veličković, Suzana, Pajović, Snežana B., Drakulić, Dunja, "TiO2 nanoparticles and TiO2 nanoparticles surface modified with salicylic acid affect neurological functions and oxidative stress markers in the eyes of adult rats" in ICCBIKG 2023 : 2nd International Conference on Chemo and Bioinformatics : Book of Proceedings (2023):499-502,
https://doi.org/10.46793/ICCBI23.499B . .

TY  - JOUR
AU  - Gavrilović, Ljubica
AU  - Stojiljković, Vesna
AU  - Stanić, Vojislav
AU  - Jovanović, Dragoljub
AU  - Pejić, Snežana
AU  - Borović, Branka
AU  - Pajović, Snežana B.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12395
AB  - inden honey represents a unique honey variety valued for its nutritional benefits, distinctive taste and aroma. Phenols, polyphenols, flavonoids, ascorbic acid and phenolic acids in honey have antioxidant activities. This study aimed to investigate the effects of linden honey on the activities of antioxidant enzymes catalase (CAT) and glutathione peroxidase (GPx), as well as on the concentration of malondialdehyde (MDA) in individually housed animals. The investigated parameters were quantified using spectrophotometric method for determination of enzyme activities and MDA concentration in the blood. We found that treatment with linden honey in the socially isolated animals significantly increased the enzyme activities of CAT and GPx, and significantly decreased the concentration of MDA. The modulation of CAT and GPx activities in socially isolated animals treated with linden honey may be very important for understanding the role of honey in the capacity of antioxidant defense system to increase and maintain its stability in psychosocial stress conditions. Our results may be important in biomedical research for understanding the role of honey in the amelioration of oxidative stress.
AB  - Lipov med predstavlja jedinstvenu vrstu meda cenjenu zbog svoje nutritivne prednosti, specifičnog ukusa i mirisa. Fenoli, polifenoli, fl avonoidi, askorbinska kiselina i fenolne kiseline u medu imaju antioksidativno dejstvo. Ovo istraživanje je imalo za cilj da ispita uticaj lipovog meda na aktivnosti antioksidativnih enzima katalaze (CAT) i glutation peroksidaze (GPx), kao i na koncentraciju malondialdehida (MDA) kod individualno smeštenih životinja. Ispitivani parametri su kvantifi kovani spektrofotometrijskim metodama. Ustanovili smo da tretman lipovim medom, kod socijalno izolovanih životinja, značajno povećava aktivnost enzima CAT i GPx, ali da značajno smanjuje koncentraciju MDA. Modulacija aktivnosti CAT i GPx u krvi socijalno izolovanih životinja tretiranih lipovim medom, može biti veoma važna za razumevanje uloge meda u sposobnosti antioksidativnog odbrambenog sistema da poveća i održi njegovu stabilnost u uslovima psihosocijalnog stresa. Naši rezultati mogu biti važni u biomedicinskim istraživanjima za razumevanje uloge meda u smanjenju oksidativnog stresa.
T2  - Acta Veterinaria
T1  - Antioxidant Status in the Blood of Psychosocially Stressed Rats Treated with Honey
T1  - Antioksidativni status u krvi pacova izlaganih psihosocijalnom stresu tretiranih medom
VL  - 73
IS  - 4
SP  - 464
EP  - 472
DO  - 10.2478/acve-2023-0035
ER  - 

@article{
author = "Gavrilović, Ljubica and Stojiljković, Vesna and Stanić, Vojislav and Jovanović, Dragoljub and Pejić, Snežana and Borović, Branka and Pajović, Snežana B.",
year = "2023",
abstract = "inden honey represents a unique honey variety valued for its nutritional benefits, distinctive taste and aroma. Phenols, polyphenols, flavonoids, ascorbic acid and phenolic acids in honey have antioxidant activities. This study aimed to investigate the effects of linden honey on the activities of antioxidant enzymes catalase (CAT) and glutathione peroxidase (GPx), as well as on the concentration of malondialdehyde (MDA) in individually housed animals. The investigated parameters were quantified using spectrophotometric method for determination of enzyme activities and MDA concentration in the blood. We found that treatment with linden honey in the socially isolated animals significantly increased the enzyme activities of CAT and GPx, and significantly decreased the concentration of MDA. The modulation of CAT and GPx activities in socially isolated animals treated with linden honey may be very important for understanding the role of honey in the capacity of antioxidant defense system to increase and maintain its stability in psychosocial stress conditions. Our results may be important in biomedical research for understanding the role of honey in the amelioration of oxidative stress., Lipov med predstavlja jedinstvenu vrstu meda cenjenu zbog svoje nutritivne prednosti, specifičnog ukusa i mirisa. Fenoli, polifenoli, fl avonoidi, askorbinska kiselina i fenolne kiseline u medu imaju antioksidativno dejstvo. Ovo istraživanje je imalo za cilj da ispita uticaj lipovog meda na aktivnosti antioksidativnih enzima katalaze (CAT) i glutation peroksidaze (GPx), kao i na koncentraciju malondialdehida (MDA) kod individualno smeštenih životinja. Ispitivani parametri su kvantifi kovani spektrofotometrijskim metodama. Ustanovili smo da tretman lipovim medom, kod socijalno izolovanih životinja, značajno povećava aktivnost enzima CAT i GPx, ali da značajno smanjuje koncentraciju MDA. Modulacija aktivnosti CAT i GPx u krvi socijalno izolovanih životinja tretiranih lipovim medom, može biti veoma važna za razumevanje uloge meda u sposobnosti antioksidativnog odbrambenog sistema da poveća i održi njegovu stabilnost u uslovima psihosocijalnog stresa. Naši rezultati mogu biti važni u biomedicinskim istraživanjima za razumevanje uloge meda u smanjenju oksidativnog stresa.",
journal = "Acta Veterinaria",
title = "Antioxidant Status in the Blood of Psychosocially Stressed Rats Treated with Honey, Antioksidativni status u krvi pacova izlaganih psihosocijalnom stresu tretiranih medom",
volume = "73",
number = "4",
pages = "464-472",
doi = "10.2478/acve-2023-0035"
}

Gavrilović, L., Stojiljković, V., Stanić, V., Jovanović, D., Pejić, S., Borović, B.,& Pajović, S. B.. (2023). Antioxidant Status in the Blood of Psychosocially Stressed Rats Treated with Honey. in Acta Veterinaria, 73(4), 464-472.
https://doi.org/10.2478/acve-2023-0035

Gavrilović L, Stojiljković V, Stanić V, Jovanović D, Pejić S, Borović B, Pajović SB. Antioxidant Status in the Blood of Psychosocially Stressed Rats Treated with Honey. in Acta Veterinaria. 2023;73(4):464-472.
doi:10.2478/acve-2023-0035 .

Gavrilović, Ljubica, Stojiljković, Vesna, Stanić, Vojislav, Jovanović, Dragoljub, Pejić, Snežana, Borović, Branka, Pajović, Snežana B., "Antioxidant Status in the Blood of Psychosocially Stressed Rats Treated with Honey" in Acta Veterinaria, 73, no. 4 (2023):464-472,
https://doi.org/10.2478/acve-2023-0035 . .

TY  - CONF
AU  - Bobić, Katarina
AU  - Milovanović, Tijana
AU  - Todorović, Ana
AU  - Drakulić, Dunja
AU  - Pejić, Snežana
AU  - Veljković, Filip
AU  - Pajović, Snežana
AU  - Nedeljković, Jovan
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12662
AB  - Široka primena nanočestica titanijum-dioksida (TiO2 NČ) u medicini, farmaceutskoj, prehrambenoj i hemijskoj industriji,1 čini TiO2 NČ visoko zastupljenim u životnoj sredini i svim sferama čovekovog života. Negativne efekte ostvaruju u mozgu, s obzirom da lako prolaze krvno-moždanu barijeru, akumuliraju se u različitim regionima mozga i indukuju oksidativni stres tokom kog se oštećuju svi biomolekuli, uključujući i lipide.2 Literaturni podaci ukazuju da različite modifikacije mogu ublažiti uočene efekte, stoga je cilj ovog rada bio da se uporedi odgovor odraslih Wistar pacova 14 dana nakon jednokratnog oralnog tretmana sa komercijalno dostupnim TiO2 NČ i TiO2 NČ površinski modifikovanim salicilnom (TiO2/SK NČ) odnosno 5- aminosalicilnom kiselinom (TiO2/5-ASK NČ). Odgovarajućim testovima praćene su promene parametara senzorno-motorne funkcije (SMF), kao pokazatelja neurološkog deficita, dok je oksidativni stres praćen promenom nivoa lipidne peroksidacije (LPO) u ukupnom ćelijskom ekstraktu moždanog tkiva. Dobijeni rezultati ukazuju da TiO2/SK NČ ispoljavaju slične efekte kao TiO2 NČ, povećavajući nivo LPO koji može biti uzrok narušene SMF. Sa druge strane, smanjen stepen neurološkog deficita i nivoa oksidativnog stresa nakon TiO2/5- ASK NČ tretmana, mogu se povezati sa povećanjem aktivnosti komponenti antioksidativne zaštite. Stoga, može se pretpostaviti da površinska modifikacija TiO2 NČ sa 5-ASK ima sposobnost ublažavanja štetnih efekata komercijalno dostupnih TiO2 NČ.
PB  - Beograd : Srpsko biološko društvo
C3  - Treći kongres biologa Srbije : Osnovna i primenjena istraživanja, metodika nastave : Knjiga sažetaka
T1  - Površinska modifikacija nanočestica titanijum dioksida aminosalicilnom kiselinom ublažava neurološki deficit i lipidnu peroksidaciju u mozgu Wistar pacova
SP  - 311
EP  - 311
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12662
ER  - 

@conference{
author = "Bobić, Katarina and Milovanović, Tijana and Todorović, Ana and Drakulić, Dunja and Pejić, Snežana and Veljković, Filip and Pajović, Snežana and Nedeljković, Jovan",
year = "2022",
abstract = "Široka primena nanočestica titanijum-dioksida (TiO2 NČ) u medicini, farmaceutskoj, prehrambenoj i hemijskoj industriji,1 čini TiO2 NČ visoko zastupljenim u životnoj sredini i svim sferama čovekovog života. Negativne efekte ostvaruju u mozgu, s obzirom da lako prolaze krvno-moždanu barijeru, akumuliraju se u različitim regionima mozga i indukuju oksidativni stres tokom kog se oštećuju svi biomolekuli, uključujući i lipide.2 Literaturni podaci ukazuju da različite modifikacije mogu ublažiti uočene efekte, stoga je cilj ovog rada bio da se uporedi odgovor odraslih Wistar pacova 14 dana nakon jednokratnog oralnog tretmana sa komercijalno dostupnim TiO2 NČ i TiO2 NČ površinski modifikovanim salicilnom (TiO2/SK NČ) odnosno 5- aminosalicilnom kiselinom (TiO2/5-ASK NČ). Odgovarajućim testovima praćene su promene parametara senzorno-motorne funkcije (SMF), kao pokazatelja neurološkog deficita, dok je oksidativni stres praćen promenom nivoa lipidne peroksidacije (LPO) u ukupnom ćelijskom ekstraktu moždanog tkiva. Dobijeni rezultati ukazuju da TiO2/SK NČ ispoljavaju slične efekte kao TiO2 NČ, povećavajući nivo LPO koji može biti uzrok narušene SMF. Sa druge strane, smanjen stepen neurološkog deficita i nivoa oksidativnog stresa nakon TiO2/5- ASK NČ tretmana, mogu se povezati sa povećanjem aktivnosti komponenti antioksidativne zaštite. Stoga, može se pretpostaviti da površinska modifikacija TiO2 NČ sa 5-ASK ima sposobnost ublažavanja štetnih efekata komercijalno dostupnih TiO2 NČ.",
publisher = "Beograd : Srpsko biološko društvo",
journal = "Treći kongres biologa Srbije : Osnovna i primenjena istraživanja, metodika nastave : Knjiga sažetaka",
title = "Površinska modifikacija nanočestica titanijum dioksida aminosalicilnom kiselinom ublažava neurološki deficit i lipidnu peroksidaciju u mozgu Wistar pacova",
pages = "311-311",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12662"
}

Bobić, K., Milovanović, T., Todorović, A., Drakulić, D., Pejić, S., Veljković, F., Pajović, S.,& Nedeljković, J.. (2022). Površinska modifikacija nanočestica titanijum dioksida aminosalicilnom kiselinom ublažava neurološki deficit i lipidnu peroksidaciju u mozgu Wistar pacova. in Treći kongres biologa Srbije : Osnovna i primenjena istraživanja, metodika nastave : Knjiga sažetaka
Beograd : Srpsko biološko društvo., 311-311.
https://hdl.handle.net/21.15107/rcub_vinar_12662

Bobić K, Milovanović T, Todorović A, Drakulić D, Pejić S, Veljković F, Pajović S, Nedeljković J. Površinska modifikacija nanočestica titanijum dioksida aminosalicilnom kiselinom ublažava neurološki deficit i lipidnu peroksidaciju u mozgu Wistar pacova. in Treći kongres biologa Srbije : Osnovna i primenjena istraživanja, metodika nastave : Knjiga sažetaka. 2022;:311-311.
https://hdl.handle.net/21.15107/rcub_vinar_12662 .

Bobić, Katarina, Milovanović, Tijana, Todorović, Ana, Drakulić, Dunja, Pejić, Snežana, Veljković, Filip, Pajović, Snežana, Nedeljković, Jovan, "Površinska modifikacija nanočestica titanijum dioksida aminosalicilnom kiselinom ublažava neurološki deficit i lipidnu peroksidaciju u mozgu Wistar pacova" in Treći kongres biologa Srbije : Osnovna i primenjena istraživanja, metodika nastave : Knjiga sažetaka (2022):311-311,
https://hdl.handle.net/21.15107/rcub_vinar_12662 .

TY  - CONF
AU  - Bobić, Katarina
AU  - Todorović, Ana
AU  - Pejić, Snežana
AU  - Veljković, Filip
AU  - Pajović, Snežana
AU  - Nedeljković, Jovan
AU  - Drakulić, Dunja
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12741
AB  - Titanium dioxide nanoparticles (TiO2 NPs) are widely used in many daily necessities, including medicine, food/ beverages, and cosmetics. Besides the numerous benefits of TiO2 NPs utilization, their use raises public concerns since humans are exposed to their toxicity. As different alterations could moderate the observed side effects of commercially available bare TiO2 NPs, we investigated whether TiO2/SA NPs (TiO2 NPs surface‑modified with salicylic acid (SA)) impact the bare TiO2 NPs-induced sensory-motor impairments and eye level of 4-hydroxynonenal (HNE) as the final product of lipid peroxidation and indicator of oxidative stress. Our results demonstrate that 14 days following single oral treatment both investigated TiO2 NPs in adult Wistar rats affected neurological functions and promoted oxidative stress to different extents. Namely, the SA modification alleviated TiO2 NPs-induced asymmetry in four limb movement, while the hind limb clasping reflex and spontaneous activity scores were similar between TiO2 groups. In the eye crude membrane fraction of TiO2/SA NPs-treated rats in comparison to animals treated with bare TiO2 NPs, the HNE level was downregulated. Although SA exhibits the ability to reduce some TiO2 NPs toxicity, due to still unknown mechanism of TiO2 and TiO2/SA NPs actions, further studies are required to verify herein presented findings
PB  - Poland : Nencki Institute of experimental biology
C3  - Acta Neurobiologiae experimentalis : NEURONUS 2022 : 12th Neuronus 2022 Neuroscience Forum : Abstracts
T1  - Surface modification of TiO2 nanoparticles moderates neurological impairments and upregulated oxidative stress indicator in eyes of adult Wistar rats
VL  - 82
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12741
ER  - 

@conference{
author = "Bobić, Katarina and Todorović, Ana and Pejić, Snežana and Veljković, Filip and Pajović, Snežana and Nedeljković, Jovan and Drakulić, Dunja",
year = "2022",
abstract = "Titanium dioxide nanoparticles (TiO2 NPs) are widely used in many daily necessities, including medicine, food/ beverages, and cosmetics. Besides the numerous benefits of TiO2 NPs utilization, their use raises public concerns since humans are exposed to their toxicity. As different alterations could moderate the observed side effects of commercially available bare TiO2 NPs, we investigated whether TiO2/SA NPs (TiO2 NPs surface‑modified with salicylic acid (SA)) impact the bare TiO2 NPs-induced sensory-motor impairments and eye level of 4-hydroxynonenal (HNE) as the final product of lipid peroxidation and indicator of oxidative stress. Our results demonstrate that 14 days following single oral treatment both investigated TiO2 NPs in adult Wistar rats affected neurological functions and promoted oxidative stress to different extents. Namely, the SA modification alleviated TiO2 NPs-induced asymmetry in four limb movement, while the hind limb clasping reflex and spontaneous activity scores were similar between TiO2 groups. In the eye crude membrane fraction of TiO2/SA NPs-treated rats in comparison to animals treated with bare TiO2 NPs, the HNE level was downregulated. Although SA exhibits the ability to reduce some TiO2 NPs toxicity, due to still unknown mechanism of TiO2 and TiO2/SA NPs actions, further studies are required to verify herein presented findings",
publisher = "Poland : Nencki Institute of experimental biology",
journal = "Acta Neurobiologiae experimentalis : NEURONUS 2022 : 12th Neuronus 2022 Neuroscience Forum : Abstracts",
title = "Surface modification of TiO2 nanoparticles moderates neurological impairments and upregulated oxidative stress indicator in eyes of adult Wistar rats",
volume = "82",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12741"
}

Bobić, K., Todorović, A., Pejić, S., Veljković, F., Pajović, S., Nedeljković, J.,& Drakulić, D.. (2022). Surface modification of TiO2 nanoparticles moderates neurological impairments and upregulated oxidative stress indicator in eyes of adult Wistar rats. in Acta Neurobiologiae experimentalis : NEURONUS 2022 : 12th Neuronus 2022 Neuroscience Forum : Abstracts
Poland : Nencki Institute of experimental biology., 82.
https://hdl.handle.net/21.15107/rcub_vinar_12741

Bobić K, Todorović A, Pejić S, Veljković F, Pajović S, Nedeljković J, Drakulić D. Surface modification of TiO2 nanoparticles moderates neurological impairments and upregulated oxidative stress indicator in eyes of adult Wistar rats. in Acta Neurobiologiae experimentalis : NEURONUS 2022 : 12th Neuronus 2022 Neuroscience Forum : Abstracts. 2022;82.
https://hdl.handle.net/21.15107/rcub_vinar_12741 .

Bobić, Katarina, Todorović, Ana, Pejić, Snežana, Veljković, Filip, Pajović, Snežana, Nedeljković, Jovan, Drakulić, Dunja, "Surface modification of TiO2 nanoparticles moderates neurological impairments and upregulated oxidative stress indicator in eyes of adult Wistar rats" in Acta Neurobiologiae experimentalis : NEURONUS 2022 : 12th Neuronus 2022 Neuroscience Forum : Abstracts, 82 (2022),
https://hdl.handle.net/21.15107/rcub_vinar_12741 .

TY  - CONF
AU  - Todorović, Ana
AU  - Pejić, Snežana
AU  - Bobić, Katarina
AU  - Milovanović, Tijana
AU  - Stanković, Sanja
AU  - Drakulić, Dunja
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12742
AB  - Titanium dioxide nanoparticles (TiO2 NPs) are commonly used in various industrial and consumer products, including cosmetics, pharmaceuticals, food and beverages, etc. Since bare TiO2 NPs pose a risk to reproductive health, we compared their toxic effect to effect of TiO2 NPs surface-modified with salicylic acid (TiO2/SA NPs) or 5-amino salicylic acid (TiO2/5-ASA NPs) in female rats 14 days after acute oral treatment. In rat ovaries, oviducts, and uterus, bare TiO2 NPs and TiO2/SA NPs promoted acute toxicity along with the hormonal imbalance, irregular estrous cycle, swelling of the genital organs that increased organ-to-body mass ratio accompanied with prooxidative shift in redox status. The observed effects were less pronounced in TiO2/5-ASA NPs-treated rats. According to the presented results, surface-binding of 5-ASA, but not SA are able to suppress the toxic effects of bare TiO2 NPs in rat female reproductive system. Further studies are necessary to confirm these assumptions.
PB  - Belgrade : Society of Physical Chemists of Serbia
C3  - PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Book of abstracts
T1  - Acute oral intake of surface-modified TiO2 nanoparticles promotes biochemical and morphological changes in rat female reproductive system
SP  - 73
EP  - 73
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12742
ER  - 

@conference{
author = "Todorović, Ana and Pejić, Snežana and Bobić, Katarina and Milovanović, Tijana and Stanković, Sanja and Drakulić, Dunja",
year = "2022",
abstract = "Titanium dioxide nanoparticles (TiO2 NPs) are commonly used in various industrial and consumer products, including cosmetics, pharmaceuticals, food and beverages, etc. Since bare TiO2 NPs pose a risk to reproductive health, we compared their toxic effect to effect of TiO2 NPs surface-modified with salicylic acid (TiO2/SA NPs) or 5-amino salicylic acid (TiO2/5-ASA NPs) in female rats 14 days after acute oral treatment. In rat ovaries, oviducts, and uterus, bare TiO2 NPs and TiO2/SA NPs promoted acute toxicity along with the hormonal imbalance, irregular estrous cycle, swelling of the genital organs that increased organ-to-body mass ratio accompanied with prooxidative shift in redox status. The observed effects were less pronounced in TiO2/5-ASA NPs-treated rats. According to the presented results, surface-binding of 5-ASA, but not SA are able to suppress the toxic effects of bare TiO2 NPs in rat female reproductive system. Further studies are necessary to confirm these assumptions.",
publisher = "Belgrade : Society of Physical Chemists of Serbia",
journal = "PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Book of abstracts",
title = "Acute oral intake of surface-modified TiO2 nanoparticles promotes biochemical and morphological changes in rat female reproductive system",
pages = "73-73",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12742"
}

Todorović, A., Pejić, S., Bobić, K., Milovanović, T., Stanković, S.,& Drakulić, D.. (2022). Acute oral intake of surface-modified TiO2 nanoparticles promotes biochemical and morphological changes in rat female reproductive system. in PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Book of abstracts
Belgrade : Society of Physical Chemists of Serbia., 73-73.
https://hdl.handle.net/21.15107/rcub_vinar_12742

Todorović A, Pejić S, Bobić K, Milovanović T, Stanković S, Drakulić D. Acute oral intake of surface-modified TiO2 nanoparticles promotes biochemical and morphological changes in rat female reproductive system. in PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Book of abstracts. 2022;:73-73.
https://hdl.handle.net/21.15107/rcub_vinar_12742 .

Todorović, Ana, Pejić, Snežana, Bobić, Katarina, Milovanović, Tijana, Stanković, Sanja, Drakulić, Dunja, "Acute oral intake of surface-modified TiO2 nanoparticles promotes biochemical and morphological changes in rat female reproductive system" in PHYSICAL CHEMISTRY 2022 : 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry : Book of abstracts (2022):73-73,
https://hdl.handle.net/21.15107/rcub_vinar_12742 .

TY  - JOUR
AU  - Đurašević, Siniša
AU  - Ružičić, Aleksandra
AU  - Lakić, Iva
AU  - Tosti, Tomislav
AU  - Đurović, Saša
AU  - Glumac, Sofija
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Drakulić, Dunja R.
AU  - Stanković, Sanja
AU  - Jasnić, Nebojša
AU  - Đorđević, Jelena
AU  - Todorović, Zoran
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10173
AB  - A dysregulated and overwhelming response to an infection accompanied by the exaggerated pro-inflammatory state and metabolism disturbance leads to the fatal outcome in sepsis. Previously we showed that meldonium, an anti-ischemic drug clinically used to treat myocardial and cerebral ischemia, strongly increases mortality in faecal-induced peritonitis (FIP) in rats. We postulated that the same mechanism that is responsible for the otherwise strong anti-inflammatory effects of meldonium could be the culprit of the increased mortality. In the present study, we applied the LPS-induced model of sepsis to explore the presence of any differences from and/or similarities to the FIP model. When it comes to energy production, despite some shared similarities, it is evident that LPS and FIP models of sepsis differ greatly. A different profile of sympathoadrenal activation may account for this observation, as it was lacking in the FIP model, whereas in the LPS model it was strong enough to overcome the effects of meldonium. Therefore, choosing the appropriate model of sepsis induction is of great importance, especially if energy homeostasis is the main focus of the study. Even when differences in the experimental design of the two models are acknowledged, the role of different patterns of energy production cannot be excluded. On that account, our results draw attention to the importance of uninterrupted energy production in sepsis but also call for much-needed revisions of the current recommendations for its treatment.
T2  - International Journal of Molecular Sciences
T1  - The Effects of a Meldonium Pre-Treatment on the Course of the LPS-Induced Sepsis in Rats
VL  - 23
IS  - 4
SP  - 2395
DO  - 10.3390/ijms23042395
ER  - 

@article{
author = "Đurašević, Siniša and Ružičić, Aleksandra and Lakić, Iva and Tosti, Tomislav and Đurović, Saša and Glumac, Sofija and Pejić, Snežana and Todorović, Ana and Drakulić, Dunja R. and Stanković, Sanja and Jasnić, Nebojša and Đorđević, Jelena and Todorović, Zoran",
year = "2022",
abstract = "A dysregulated and overwhelming response to an infection accompanied by the exaggerated pro-inflammatory state and metabolism disturbance leads to the fatal outcome in sepsis. Previously we showed that meldonium, an anti-ischemic drug clinically used to treat myocardial and cerebral ischemia, strongly increases mortality in faecal-induced peritonitis (FIP) in rats. We postulated that the same mechanism that is responsible for the otherwise strong anti-inflammatory effects of meldonium could be the culprit of the increased mortality. In the present study, we applied the LPS-induced model of sepsis to explore the presence of any differences from and/or similarities to the FIP model. When it comes to energy production, despite some shared similarities, it is evident that LPS and FIP models of sepsis differ greatly. A different profile of sympathoadrenal activation may account for this observation, as it was lacking in the FIP model, whereas in the LPS model it was strong enough to overcome the effects of meldonium. Therefore, choosing the appropriate model of sepsis induction is of great importance, especially if energy homeostasis is the main focus of the study. Even when differences in the experimental design of the two models are acknowledged, the role of different patterns of energy production cannot be excluded. On that account, our results draw attention to the importance of uninterrupted energy production in sepsis but also call for much-needed revisions of the current recommendations for its treatment.",
journal = "International Journal of Molecular Sciences",
title = "The Effects of a Meldonium Pre-Treatment on the Course of the LPS-Induced Sepsis in Rats",
volume = "23",
number = "4",
pages = "2395",
doi = "10.3390/ijms23042395"
}

Đurašević, S., Ružičić, A., Lakić, I., Tosti, T., Đurović, S., Glumac, S., Pejić, S., Todorović, A., Drakulić, D. R., Stanković, S., Jasnić, N., Đorđević, J.,& Todorović, Z.. (2022). The Effects of a Meldonium Pre-Treatment on the Course of the LPS-Induced Sepsis in Rats. in International Journal of Molecular Sciences, 23(4), 2395.
https://doi.org/10.3390/ijms23042395

Đurašević S, Ružičić A, Lakić I, Tosti T, Đurović S, Glumac S, Pejić S, Todorović A, Drakulić DR, Stanković S, Jasnić N, Đorđević J, Todorović Z. The Effects of a Meldonium Pre-Treatment on the Course of the LPS-Induced Sepsis in Rats. in International Journal of Molecular Sciences. 2022;23(4):2395.
doi:10.3390/ijms23042395 .

Đurašević, Siniša, Ružičić, Aleksandra, Lakić, Iva, Tosti, Tomislav, Đurović, Saša, Glumac, Sofija, Pejić, Snežana, Todorović, Ana, Drakulić, Dunja R., Stanković, Sanja, Jasnić, Nebojša, Đorđević, Jelena, Todorović, Zoran, "The Effects of a Meldonium Pre-Treatment on the Course of the LPS-Induced Sepsis in Rats" in International Journal of Molecular Sciences, 23, no. 4 (2022):2395,
https://doi.org/10.3390/ijms23042395 . .

TY  - JOUR
AU  - Pantić, Igor
AU  - Paunović, Jovana
AU  - Pejić, Snežana
AU  - Drakulić, Dunja R.
AU  - Todorović, Ana
AU  - Stanković, Sanja
AU  - Vučević, Danijela
AU  - Cumic, Jelena
AU  - Radosavljević, Tatjana
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10212
AB  - Artificial intelligence (AI) and machine learning models are today frequently used for classification and prediction of various biochemical processes and phenomena. In recent years, numerous research efforts have been focused on developing such models for assessment, categorization, and prediction of oxidative stress. Supervised machine learning can successfully automate the process of evaluation and quantification of oxidative damage in biological samples, as well as extract useful data from the abundance of experimental results. In this concise review, we cover the possible applications of neural networks, decision trees and regression analysis as three common strategies in machine learning. We also review recent works on the various weaknesses and limitations of artificial intelligence in biochemistry and related scientific areas. Finally, we discuss future innovative approaches on the ways how AI can contribute to the automation of oxidative stress measurement and diagnosis of diseases associated with oxidative damage.
T2  - Chemico-Biological Interactions
T2  - Chemico-Biological Interactions
T1  - Artificial intelligence approaches to the biochemistry of oxidative stress: Current state of the art
VL  - 358
SP  - 109888
DO  - 10.1016/j.cbi.2022.109888
ER  - 

@article{
author = "Pantić, Igor and Paunović, Jovana and Pejić, Snežana and Drakulić, Dunja R. and Todorović, Ana and Stanković, Sanja and Vučević, Danijela and Cumic, Jelena and Radosavljević, Tatjana",
year = "2022",
abstract = "Artificial intelligence (AI) and machine learning models are today frequently used for classification and prediction of various biochemical processes and phenomena. In recent years, numerous research efforts have been focused on developing such models for assessment, categorization, and prediction of oxidative stress. Supervised machine learning can successfully automate the process of evaluation and quantification of oxidative damage in biological samples, as well as extract useful data from the abundance of experimental results. In this concise review, we cover the possible applications of neural networks, decision trees and regression analysis as three common strategies in machine learning. We also review recent works on the various weaknesses and limitations of artificial intelligence in biochemistry and related scientific areas. Finally, we discuss future innovative approaches on the ways how AI can contribute to the automation of oxidative stress measurement and diagnosis of diseases associated with oxidative damage.",
journal = "Chemico-Biological Interactions, Chemico-Biological Interactions",
title = "Artificial intelligence approaches to the biochemistry of oxidative stress: Current state of the art",
volume = "358",
pages = "109888",
doi = "10.1016/j.cbi.2022.109888"
}

Pantić, I., Paunović, J., Pejić, S., Drakulić, D. R., Todorović, A., Stanković, S., Vučević, D., Cumic, J.,& Radosavljević, T.. (2022). Artificial intelligence approaches to the biochemistry of oxidative stress: Current state of the art. in Chemico-Biological Interactions, 358, 109888.
https://doi.org/10.1016/j.cbi.2022.109888

Pantić I, Paunović J, Pejić S, Drakulić DR, Todorović A, Stanković S, Vučević D, Cumic J, Radosavljević T. Artificial intelligence approaches to the biochemistry of oxidative stress: Current state of the art. in Chemico-Biological Interactions. 2022;358:109888.
doi:10.1016/j.cbi.2022.109888 .

Pantić, Igor, Paunović, Jovana, Pejić, Snežana, Drakulić, Dunja R., Todorović, Ana, Stanković, Sanja, Vučević, Danijela, Cumic, Jelena, Radosavljević, Tatjana, "Artificial intelligence approaches to the biochemistry of oxidative stress: Current state of the art" in Chemico-Biological Interactions, 358 (2022):109888,
https://doi.org/10.1016/j.cbi.2022.109888 . .

TY  - CONF
AU  - Žakula, Jelena
AU  - Miletić, Mirjana
AU  - Aškrabić, Sonja
AU  - Pejić, Snežana
AU  - Korićanac, Lela
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11008
AB  - The development of new types of nanoparticles has become the focus of biomedical research in recent years. Cerium oxide nanoparticles (CONP) have shown particularly promising results as antitumor agents with a selective effect on tumor and normal cells. On the other side, melanoma and pancreatic carcinoma are among the most aggressive types of cancer with no satisfactory therapy1,2 . Considering that, they represent important model systems for studying new treatment approaches. In this study, the antitumor potential of CONP (size below 10 nm) was studied on human A375 melanoma and PANC-1 pancreatic carcinoma cells. The obtained results indicated that analyzed CONP significantly inhibited clonogenic survival, with the number of colonies reduced on ~30% in A375 cells, while treated PANC-1 cells didn’t form colonies. Growth inhibition was followed by G 2 cell cycle arrest (9% for A375, 17% for PANC-1). Percent of apoptotic PANC-1 cells was 38%, whereas ROS production increased for 78%. CONP significantly reduced metastatic potential through the decrease in cell migration and the increase in cell adhesiveness (up to 30 and 40% for A375 and PANC-1 respectively). These findings emphasize the significant CONP antitumor potential, based on the increase in ROS production, as well as a reduction of A375 and PANC-1 metastatic potential.
PB  - Belgrade : Faculty of Chemistry : Serbian Biochemical Society
C3  - Serbian Biochemical Society : 11th conference - "Amazing Biochemistry" : proceedings ; September 22-23, 2022; Novi Sad, Serbia
T1  - Prooxidative and antimigratory effects of cerium oxide nanoparticles on melanoma and pancreatic cancer cells
SP  - 85
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11008
ER  - 

@conference{
author = "Žakula, Jelena and Miletić, Mirjana and Aškrabić, Sonja and Pejić, Snežana and Korićanac, Lela",
year = "2022",
abstract = "The development of new types of nanoparticles has become the focus of biomedical research in recent years. Cerium oxide nanoparticles (CONP) have shown particularly promising results as antitumor agents with a selective effect on tumor and normal cells. On the other side, melanoma and pancreatic carcinoma are among the most aggressive types of cancer with no satisfactory therapy1,2 . Considering that, they represent important model systems for studying new treatment approaches. In this study, the antitumor potential of CONP (size below 10 nm) was studied on human A375 melanoma and PANC-1 pancreatic carcinoma cells. The obtained results indicated that analyzed CONP significantly inhibited clonogenic survival, with the number of colonies reduced on ~30% in A375 cells, while treated PANC-1 cells didn’t form colonies. Growth inhibition was followed by G 2 cell cycle arrest (9% for A375, 17% for PANC-1). Percent of apoptotic PANC-1 cells was 38%, whereas ROS production increased for 78%. CONP significantly reduced metastatic potential through the decrease in cell migration and the increase in cell adhesiveness (up to 30 and 40% for A375 and PANC-1 respectively). These findings emphasize the significant CONP antitumor potential, based on the increase in ROS production, as well as a reduction of A375 and PANC-1 metastatic potential.",
publisher = "Belgrade : Faculty of Chemistry : Serbian Biochemical Society",
journal = "Serbian Biochemical Society : 11th conference - "Amazing Biochemistry" : proceedings ; September 22-23, 2022; Novi Sad, Serbia",
title = "Prooxidative and antimigratory effects of cerium oxide nanoparticles on melanoma and pancreatic cancer cells",
pages = "85",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11008"
}

Žakula, J., Miletić, M., Aškrabić, S., Pejić, S.,& Korićanac, L.. (2022). Prooxidative and antimigratory effects of cerium oxide nanoparticles on melanoma and pancreatic cancer cells. in Serbian Biochemical Society : 11th conference - "Amazing Biochemistry" : proceedings ; September 22-23, 2022; Novi Sad, Serbia
Belgrade : Faculty of Chemistry : Serbian Biochemical Society., 85.
https://hdl.handle.net/21.15107/rcub_vinar_11008

Žakula J, Miletić M, Aškrabić S, Pejić S, Korićanac L. Prooxidative and antimigratory effects of cerium oxide nanoparticles on melanoma and pancreatic cancer cells. in Serbian Biochemical Society : 11th conference - "Amazing Biochemistry" : proceedings ; September 22-23, 2022; Novi Sad, Serbia. 2022;:85.
https://hdl.handle.net/21.15107/rcub_vinar_11008 .

Žakula, Jelena, Miletić, Mirjana, Aškrabić, Sonja, Pejić, Snežana, Korićanac, Lela, "Prooxidative and antimigratory effects of cerium oxide nanoparticles on melanoma and pancreatic cancer cells" in Serbian Biochemical Society : 11th conference - "Amazing Biochemistry" : proceedings ; September 22-23, 2022; Novi Sad, Serbia (2022):85,
https://hdl.handle.net/21.15107/rcub_vinar_11008 .

TY  - CONF
AU  - Đorđević, Neda
AU  - Todorović Vukotić, Nevena
AU  - Korićanac, Lela
AU  - Žakula, Jelena
AU  - Pejić, Snežana
AU  - Pajović, Snežana B.
AU  - Tešević, V.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12586
AB  - Positive effects of moderate wine consumption in individuals with cardiovascular disease, hypertension, diabetes, and cancers have been shown in numerous epidemiological and clinical studies. This research examined the phenolic content of commercial and two clonal Merlot wines as well as their biological potential. The obtained results indicated that all analyzed samples were a good source of phenolic compounds. Cytotoxicity assay on melanoma (A375) and cervical (HeLa) cancer cell lines have shown that all analyzed wines inhibited the growth of human cancer cells in vitro with differing susceptibility among tested cell lines. Clonal wines in the volume ratio of 10 and 20% showed to be more efficient anti-proliferative agents than commercial wine regarding the A375 cells. This could be connected with higher total phenolic content in clonal wines. The effect of all analyzed samples on the A375 cells was greater compared to HeLa cell line.
PB  - Belgrade : Society of Physical Chemists of Serbia
C3  - 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2022 : Book of Abstracts
T1  - Phenolic Composition and Cytotoxic Activity of Red Wine
SP  - 153
EP  - 153
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12586
ER  - 

@conference{
author = "Đorđević, Neda and Todorović Vukotić, Nevena and Korićanac, Lela and Žakula, Jelena and Pejić, Snežana and Pajović, Snežana B. and Tešević, V.",
year = "2022",
abstract = "Positive effects of moderate wine consumption in individuals with cardiovascular disease, hypertension, diabetes, and cancers have been shown in numerous epidemiological and clinical studies. This research examined the phenolic content of commercial and two clonal Merlot wines as well as their biological potential. The obtained results indicated that all analyzed samples were a good source of phenolic compounds. Cytotoxicity assay on melanoma (A375) and cervical (HeLa) cancer cell lines have shown that all analyzed wines inhibited the growth of human cancer cells in vitro with differing susceptibility among tested cell lines. Clonal wines in the volume ratio of 10 and 20% showed to be more efficient anti-proliferative agents than commercial wine regarding the A375 cells. This could be connected with higher total phenolic content in clonal wines. The effect of all analyzed samples on the A375 cells was greater compared to HeLa cell line.",
publisher = "Belgrade : Society of Physical Chemists of Serbia",
journal = "16th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2022 : Book of Abstracts",
title = "Phenolic Composition and Cytotoxic Activity of Red Wine",
pages = "153-153",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12586"
}

Đorđević, N., Todorović Vukotić, N., Korićanac, L., Žakula, J., Pejić, S., Pajović, S. B.,& Tešević, V.. (2022). Phenolic Composition and Cytotoxic Activity of Red Wine. in 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2022 : Book of Abstracts
Belgrade : Society of Physical Chemists of Serbia., 153-153.
https://hdl.handle.net/21.15107/rcub_vinar_12586

Đorđević N, Todorović Vukotić N, Korićanac L, Žakula J, Pejić S, Pajović SB, Tešević V. Phenolic Composition and Cytotoxic Activity of Red Wine. in 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2022 : Book of Abstracts. 2022;:153-153.
https://hdl.handle.net/21.15107/rcub_vinar_12586 .

Đorđević, Neda, Todorović Vukotić, Nevena, Korićanac, Lela, Žakula, Jelena, Pejić, Snežana, Pajović, Snežana B., Tešević, V., "Phenolic Composition and Cytotoxic Activity of Red Wine" in 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2022 : Book of Abstracts (2022):153-153,
https://hdl.handle.net/21.15107/rcub_vinar_12586 .

TY  - CONF
AU  - Đorđević, Neda
AU  - Todorović Vukotić, Nevena
AU  - Korićanac, Lela
AU  - Žakula, Jelena
AU  - Pejić, Snežana
AU  - Tešević, V.
AU  - Pajović, Snežana B.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12592
AB  - Benefitni efekat crvenog vina na zdravlje ljudi od davnina je poznat. Među alkoholnim pićima crveno vino pokazuje najjači efekat protiv pojave oboljenja povezanih sa oksidativnim stresom, kao što su kardiovaskularna, neurodegenerativna oboljenja, dijabetes i kancer.1 U okviru ove studije ispitan je citotoksični efekat crvenog vina sorte merlo (komercijalno dostupno vino i vina dobijena od klonova VCR1 i VCR101) poreklom iz Crne Gore, berba 2011, u odnosu na ćelijsku liniju kancera pankreasa (PANC-1) i ćelijsku liniju melanoma (A375). Citotoksični efekat vina je određen SRB metodom kroz praćenje ćelijskog preživljavanja kancerskih ćelija 48 sati nakon tretmana sa tri različita zapreminska procenta analiziranih vina (5, 10 i 20%). Dobijeni rezultati su pokazali citotoksični efekat svih analiziranih vina na obe ćelijske linije. Ćelijsko preživljavanje nakon tretmana vinima se kretalo od 36 do 64%. Citotoksični efekat svih vina u odnosu na A375 ćelije je bio veći nego na PANC-1 ćelijsku liniju, što je od posebnog značaja ako se uzme u obzir rezistentnost melanomskih ćelija na postojeće terapeutske tretmane. Takođe, klonska sortna vina su pokazala veći citotoksični efekat na A375 ćelijsku liniju od komercijalno dostupnog vina. Dobijeni rezultati su ukazali da umereno konzumiranje crvenog vina sorte merlo sa specifičnim geografskim poreklom predstavlja dobar izvor bioaktivnih komponenata sa pozitivnim biološkim efektom, što je od posebne važnosti za klonska sortna vina.
PB  - Beograd : Srpsko biološko društvo
C3  - 3. kongres biologa Srbije : osnovna i primenjena istraživanja, metodika nastave : knjiga sažetaka
T1  - Citotoksično dejstvo crvenog vina na tumorske ćelije u in vitro uslovima
SP  - 321
EP  - 321
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12592
ER  - 

@conference{
author = "Đorđević, Neda and Todorović Vukotić, Nevena and Korićanac, Lela and Žakula, Jelena and Pejić, Snežana and Tešević, V. and Pajović, Snežana B.",
year = "2022",
abstract = "Benefitni efekat crvenog vina na zdravlje ljudi od davnina je poznat. Među alkoholnim pićima crveno vino pokazuje najjači efekat protiv pojave oboljenja povezanih sa oksidativnim stresom, kao što su kardiovaskularna, neurodegenerativna oboljenja, dijabetes i kancer.1 U okviru ove studije ispitan je citotoksični efekat crvenog vina sorte merlo (komercijalno dostupno vino i vina dobijena od klonova VCR1 i VCR101) poreklom iz Crne Gore, berba 2011, u odnosu na ćelijsku liniju kancera pankreasa (PANC-1) i ćelijsku liniju melanoma (A375). Citotoksični efekat vina je određen SRB metodom kroz praćenje ćelijskog preživljavanja kancerskih ćelija 48 sati nakon tretmana sa tri različita zapreminska procenta analiziranih vina (5, 10 i 20%). Dobijeni rezultati su pokazali citotoksični efekat svih analiziranih vina na obe ćelijske linije. Ćelijsko preživljavanje nakon tretmana vinima se kretalo od 36 do 64%. Citotoksični efekat svih vina u odnosu na A375 ćelije je bio veći nego na PANC-1 ćelijsku liniju, što je od posebnog značaja ako se uzme u obzir rezistentnost melanomskih ćelija na postojeće terapeutske tretmane. Takođe, klonska sortna vina su pokazala veći citotoksični efekat na A375 ćelijsku liniju od komercijalno dostupnog vina. Dobijeni rezultati su ukazali da umereno konzumiranje crvenog vina sorte merlo sa specifičnim geografskim poreklom predstavlja dobar izvor bioaktivnih komponenata sa pozitivnim biološkim efektom, što je od posebne važnosti za klonska sortna vina.",
publisher = "Beograd : Srpsko biološko društvo",
journal = "3. kongres biologa Srbije : osnovna i primenjena istraživanja, metodika nastave : knjiga sažetaka",
title = "Citotoksično dejstvo crvenog vina na tumorske ćelije u in vitro uslovima",
pages = "321-321",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12592"
}

Đorđević, N., Todorović Vukotić, N., Korićanac, L., Žakula, J., Pejić, S., Tešević, V.,& Pajović, S. B.. (2022). Citotoksično dejstvo crvenog vina na tumorske ćelije u in vitro uslovima. in 3. kongres biologa Srbije : osnovna i primenjena istraživanja, metodika nastave : knjiga sažetaka
Beograd : Srpsko biološko društvo., 321-321.
https://hdl.handle.net/21.15107/rcub_vinar_12592

Đorđević N, Todorović Vukotić N, Korićanac L, Žakula J, Pejić S, Tešević V, Pajović SB. Citotoksično dejstvo crvenog vina na tumorske ćelije u in vitro uslovima. in 3. kongres biologa Srbije : osnovna i primenjena istraživanja, metodika nastave : knjiga sažetaka. 2022;:321-321.
https://hdl.handle.net/21.15107/rcub_vinar_12592 .

Đorđević, Neda, Todorović Vukotić, Nevena, Korićanac, Lela, Žakula, Jelena, Pejić, Snežana, Tešević, V., Pajović, Snežana B., "Citotoksično dejstvo crvenog vina na tumorske ćelije u in vitro uslovima" in 3. kongres biologa Srbije : osnovna i primenjena istraživanja, metodika nastave : knjiga sažetaka (2022):321-321,
https://hdl.handle.net/21.15107/rcub_vinar_12592 .

TY  - JOUR
AU  - Gavrilović, Ljubica
AU  - Popović, Nataša
AU  - Stojiljković, Vesna
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Vujović, Predrag
AU  - Pajović, Snežana B.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10235
AB  - Background This study aimed to investigate the effects of lithium treatment on gene expression and activity of the prefrontal antioxidant enzymes: copper, zinc superoxide dismutase (SOD1), manganes superoxide dismutase (SOD2), catalase (CAT), and glutathione peroxidase (GPx) in animals exposed to chronic restraint stress (CRS). Methods The investigated parameters were quantified using real-time RT-PCR, Western blot analyses, and assays of enzyme activities. Results We found that lithium treatment decreased gene expression of SOD2, as well as the activities of SOD1 and SOD2 in chronically stressed rats to the levels found in unstressed animals. However, lithium treatment in animals exposed to CRS increased prefrontal GPx activity to the levels found in unstressed animals. Conclusions These findings confirm that treatment with lithium induced the modulation of prefrontal antioxidant status in chronically stressed rats. Our results may be very important in biomedical research for understanding the role of lithium in maintaining the stability of prefrontal antioxidant defense system in neuropsychiatric disorders caused by chronic stress.
T2  - PeerJ
T1  - Antioxidant defense system in the prefrontal cortex of chronically stressed rats treated with lithium
VL  - 10
SP  - e13020
DO  - 10.7717/peerj.13020
ER  - 

@article{
author = "Gavrilović, Ljubica and Popović, Nataša and Stojiljković, Vesna and Pejić, Snežana and Todorović, Ana and Vujović, Predrag and Pajović, Snežana B.",
year = "2022",
abstract = "Background This study aimed to investigate the effects of lithium treatment on gene expression and activity of the prefrontal antioxidant enzymes: copper, zinc superoxide dismutase (SOD1), manganes superoxide dismutase (SOD2), catalase (CAT), and glutathione peroxidase (GPx) in animals exposed to chronic restraint stress (CRS). Methods The investigated parameters were quantified using real-time RT-PCR, Western blot analyses, and assays of enzyme activities. Results We found that lithium treatment decreased gene expression of SOD2, as well as the activities of SOD1 and SOD2 in chronically stressed rats to the levels found in unstressed animals. However, lithium treatment in animals exposed to CRS increased prefrontal GPx activity to the levels found in unstressed animals. Conclusions These findings confirm that treatment with lithium induced the modulation of prefrontal antioxidant status in chronically stressed rats. Our results may be very important in biomedical research for understanding the role of lithium in maintaining the stability of prefrontal antioxidant defense system in neuropsychiatric disorders caused by chronic stress.",
journal = "PeerJ",
title = "Antioxidant defense system in the prefrontal cortex of chronically stressed rats treated with lithium",
volume = "10",
pages = "e13020",
doi = "10.7717/peerj.13020"
}

Gavrilović, L., Popović, N., Stojiljković, V., Pejić, S., Todorović, A., Vujović, P.,& Pajović, S. B.. (2022). Antioxidant defense system in the prefrontal cortex of chronically stressed rats treated with lithium. in PeerJ, 10, e13020.
https://doi.org/10.7717/peerj.13020

Gavrilović L, Popović N, Stojiljković V, Pejić S, Todorović A, Vujović P, Pajović SB. Antioxidant defense system in the prefrontal cortex of chronically stressed rats treated with lithium. in PeerJ. 2022;10:e13020.
doi:10.7717/peerj.13020 .

Gavrilović, Ljubica, Popović, Nataša, Stojiljković, Vesna, Pejić, Snežana, Todorović, Ana, Vujović, Predrag, Pajović, Snežana B., "Antioxidant defense system in the prefrontal cortex of chronically stressed rats treated with lithium" in PeerJ, 10 (2022):e13020,
https://doi.org/10.7717/peerj.13020 . .

TY  - JOUR
AU  - Gavrilović, Ljubica
AU  - Stojiljković, Vesna
AU  - Pejić, Snežana
AU  - Spasojević-Tišma, Vera D.
AU  - Nikolić, Dragan
AU  - Pajović, Snežana B.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10374
AB  - The aim of this study was to examine whether there are differences in adrenomedullary function in respect to the left and right sides in chronic stress conditions. We investigated how chronic stress isolation (CSI 12 weeks) affected the protein levels of key enzymes involved in adrenaline (A) synthesis (phenyl ethanolamine N-methyltransferase -PNMT), storage (vesicular monoamine transporters 2 - VMAT2) and degradation (catechol-O-methyltransferase - COMT), as well as the concentrations of A as an index for adrenomedullary function in the left and right adrenal medulla. Also, we examined the concentrations of malondialdehyde (MDA), protein levels of nuclear factor κB (NF-κB), and activity of catalase (CAT) in the left and right adrenal medulla. The investigated parameters were quantified by Western blot analysis, assay of enzymatic activity, and CAT Research ELISA kits. We found that CSI pro duced significantly increased levels of PNMT protein, and VMAT2 protein, as well as increased concentrations of A in the right adrenal medulla. However, we recorded that CSI increased protein levels of COMT and NF-κB, as well as the concentrations of MDA in the left adrenal medulla. Also, CSI decreased the activity of CAT only in the left adrenal medulla. Based on these results, it may be
T2  - Acta Veterinaria
T1  - Differences in the Functional Activity and Redox Homeostasis Between the Left and Right Adrenal Gland of Rats Exposed to Chronic Isolation Stress
VL  - 72
IS  - 2
SP  - 224
EP  - 234
DO  - 10.2478/acve-2022-0018
ER  - 

@article{
author = "Gavrilović, Ljubica and Stojiljković, Vesna and Pejić, Snežana and Spasojević-Tišma, Vera D. and Nikolić, Dragan and Pajović, Snežana B.",
year = "2022",
abstract = "The aim of this study was to examine whether there are differences in adrenomedullary function in respect to the left and right sides in chronic stress conditions. We investigated how chronic stress isolation (CSI 12 weeks) affected the protein levels of key enzymes involved in adrenaline (A) synthesis (phenyl ethanolamine N-methyltransferase -PNMT), storage (vesicular monoamine transporters 2 - VMAT2) and degradation (catechol-O-methyltransferase - COMT), as well as the concentrations of A as an index for adrenomedullary function in the left and right adrenal medulla. Also, we examined the concentrations of malondialdehyde (MDA), protein levels of nuclear factor κB (NF-κB), and activity of catalase (CAT) in the left and right adrenal medulla. The investigated parameters were quantified by Western blot analysis, assay of enzymatic activity, and CAT Research ELISA kits. We found that CSI pro duced significantly increased levels of PNMT protein, and VMAT2 protein, as well as increased concentrations of A in the right adrenal medulla. However, we recorded that CSI increased protein levels of COMT and NF-κB, as well as the concentrations of MDA in the left adrenal medulla. Also, CSI decreased the activity of CAT only in the left adrenal medulla. Based on these results, it may be",
journal = "Acta Veterinaria",
title = "Differences in the Functional Activity and Redox Homeostasis Between the Left and Right Adrenal Gland of Rats Exposed to Chronic Isolation Stress",
volume = "72",
number = "2",
pages = "224-234",
doi = "10.2478/acve-2022-0018"
}

Gavrilović, L., Stojiljković, V., Pejić, S., Spasojević-Tišma, V. D., Nikolić, D.,& Pajović, S. B.. (2022). Differences in the Functional Activity and Redox Homeostasis Between the Left and Right Adrenal Gland of Rats Exposed to Chronic Isolation Stress. in Acta Veterinaria, 72(2), 224-234.
https://doi.org/10.2478/acve-2022-0018

Gavrilović L, Stojiljković V, Pejić S, Spasojević-Tišma VD, Nikolić D, Pajović SB. Differences in the Functional Activity and Redox Homeostasis Between the Left and Right Adrenal Gland of Rats Exposed to Chronic Isolation Stress. in Acta Veterinaria. 2022;72(2):224-234.
doi:10.2478/acve-2022-0018 .

Gavrilović, Ljubica, Stojiljković, Vesna, Pejić, Snežana, Spasojević-Tišma, Vera D., Nikolić, Dragan, Pajović, Snežana B., "Differences in the Functional Activity and Redox Homeostasis Between the Left and Right Adrenal Gland of Rats Exposed to Chronic Isolation Stress" in Acta Veterinaria, 72, no. 2 (2022):224-234,
https://doi.org/10.2478/acve-2022-0018 . .

TY  - CONF
AU  - Bobić, Katarina
AU  - Guševac Stojanović, Ivana
AU  - Todorović, Ana
AU  - Veljković, Filip
AU  - Pejić, Snežana
AU  - Martinović, Jelena
AU  - Drakulić, Dunja
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11007
AB  - Progesterone (P4), a naturally occurring gonadal hormone in the brain, and its metabolites, are proposed as potential therapeutic agents in various neurodegenerative animal models given that their neuroprotective properties might be associated with amelioration of oxidative stress. Since P4 actions in rat striatum upon permanent ligation of both common carotid arteries are still ambiguous, the present study aimed to evaluate whether 7 days lasting P4 treatment could modulate the levels of several striatal oxidative stress indicators, including prooxidant/antioxidant balance (PAB), advanced oxidation protein products (AOPP) and products of lipid peroxidation (LPO). For the purpose of the experiment, adult male Wistar rats (n = 12) were divided into 3 groups: sham-operated animals subjected to vehicle (commercial flax oil, 1 mg/kg, s.c., Sham + V), occluded animals treated either with vehicle (2VO + V) or P4 (dissolved in commercial flax oil, 1.7 mg/kg, s.c., 2VO + P4). Rats were sacrificed 4 h following the last treatment1 and striatal synaptosomal fraction was used for further biochemical analyses 2. Our results demonstrate that investigated oxidative stress indicators are affected to the different extents by P4 treatment. Namely, in comparison to the Sham + V group, PAB level was elevated in 2VO + V rats, while in 2VO + P4 animals it was downregulated to the levels observed in the Sham + V group. In parallel, 2VO-induced alteration of AOPP was decreased following P4 treatment whereas LPO level was still slightly elevated. Overall, our findings suggest that P4 might manifest antioxidative features in the striatum of hypoperfused rats.
PB  - Belgrade : Faculty of Chemistry : Serbian Biochemical Society
C3  - Serbian Biochemical Society : 11th conference - "Amazing Biochemistry" : proceedings ; September 22-23, 2022; Novi Sad, Serbia
T1  - Antioxidative properties of progesterone in striatum of permanently occluded adult male Wistar rats
SP  - 53
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11007
ER  - 

@conference{
author = "Bobić, Katarina and Guševac Stojanović, Ivana and Todorović, Ana and Veljković, Filip and Pejić, Snežana and Martinović, Jelena and Drakulić, Dunja",
year = "2022",
abstract = "Progesterone (P4), a naturally occurring gonadal hormone in the brain, and its metabolites, are proposed as potential therapeutic agents in various neurodegenerative animal models given that their neuroprotective properties might be associated with amelioration of oxidative stress. Since P4 actions in rat striatum upon permanent ligation of both common carotid arteries are still ambiguous, the present study aimed to evaluate whether 7 days lasting P4 treatment could modulate the levels of several striatal oxidative stress indicators, including prooxidant/antioxidant balance (PAB), advanced oxidation protein products (AOPP) and products of lipid peroxidation (LPO). For the purpose of the experiment, adult male Wistar rats (n = 12) were divided into 3 groups: sham-operated animals subjected to vehicle (commercial flax oil, 1 mg/kg, s.c., Sham + V), occluded animals treated either with vehicle (2VO + V) or P4 (dissolved in commercial flax oil, 1.7 mg/kg, s.c., 2VO + P4). Rats were sacrificed 4 h following the last treatment1 and striatal synaptosomal fraction was used for further biochemical analyses 2. Our results demonstrate that investigated oxidative stress indicators are affected to the different extents by P4 treatment. Namely, in comparison to the Sham + V group, PAB level was elevated in 2VO + V rats, while in 2VO + P4 animals it was downregulated to the levels observed in the Sham + V group. In parallel, 2VO-induced alteration of AOPP was decreased following P4 treatment whereas LPO level was still slightly elevated. Overall, our findings suggest that P4 might manifest antioxidative features in the striatum of hypoperfused rats.",
publisher = "Belgrade : Faculty of Chemistry : Serbian Biochemical Society",
journal = "Serbian Biochemical Society : 11th conference - "Amazing Biochemistry" : proceedings ; September 22-23, 2022; Novi Sad, Serbia",
title = "Antioxidative properties of progesterone in striatum of permanently occluded adult male Wistar rats",
pages = "53",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11007"
}

Bobić, K., Guševac Stojanović, I., Todorović, A., Veljković, F., Pejić, S., Martinović, J.,& Drakulić, D.. (2022). Antioxidative properties of progesterone in striatum of permanently occluded adult male Wistar rats. in Serbian Biochemical Society : 11th conference - "Amazing Biochemistry" : proceedings ; September 22-23, 2022; Novi Sad, Serbia
Belgrade : Faculty of Chemistry : Serbian Biochemical Society., 53.
https://hdl.handle.net/21.15107/rcub_vinar_11007

Bobić K, Guševac Stojanović I, Todorović A, Veljković F, Pejić S, Martinović J, Drakulić D. Antioxidative properties of progesterone in striatum of permanently occluded adult male Wistar rats. in Serbian Biochemical Society : 11th conference - "Amazing Biochemistry" : proceedings ; September 22-23, 2022; Novi Sad, Serbia. 2022;:53.
https://hdl.handle.net/21.15107/rcub_vinar_11007 .

Bobić, Katarina, Guševac Stojanović, Ivana, Todorović, Ana, Veljković, Filip, Pejić, Snežana, Martinović, Jelena, Drakulić, Dunja, "Antioxidative properties of progesterone in striatum of permanently occluded adult male Wistar rats" in Serbian Biochemical Society : 11th conference - "Amazing Biochemistry" : proceedings ; September 22-23, 2022; Novi Sad, Serbia (2022):53,
https://hdl.handle.net/21.15107/rcub_vinar_11007 .

TY  - JOUR
AU  - Gavrilović, Ljubica
AU  - Popović, Nataša M.
AU  - Stojiljković, Vesna
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Pavlović, Ivan
AU  - Pantelić, Marija
AU  - Pajović, Snežana B.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9959
AB  - Data about the dynamics of noradrenaline (NA) transmission, storage and degradation may be very important for understanding the reduction of functional deficiency of NA and maintaining the stability of NA levels in animals with depressive-like behavior treated with lithium. This study aimed to investigate the effects of mood stabilizer lithium on concentrations of NA in the prefrontal cortex (PFC), as well as behavior rats exposed to chronic restraint stress (CRS). In addition, this study examined the effects of lithium on protein levels of noradrenaline transporter (NET), vesicular monoamine transporter 2 (VMAT2) and catechol-O-methyltransferase (COMT), as well as the enzyme activity of monoamine oxidase A (MOA) in the PFC of chronically stressed rats. METHODS: The investigated parameters were quantified by Western blot analysis, CAT Research ELISA kits, and an assay of enzyme activity. Also, the forced swim test (FST) was used to assess the behavior of animals. RESULTS: We found that lithium treatment decreased high protein levels of NET and VMAT2, as well as the enzyme activity of MOA in chronically stressed rats to the levels found in unstressed animals. In addition, lithium treatment decreased the concentration of NA (24%) and immobility in animals exposed to CRS. CONCLUSION: Our data confirm that lithium-induced modulation of prefrontal noradrenergic turnover and stabilized the behavior of chronically stressed rats.
T2  - Neuroendocrinology Letters
T1  - Effects of mood stabilizer lithium on noradrenergic turnover in the prefrontal cortex of chronically stressed rats
VL  - 42
IS  - 3
SP  - 171
EP  - 176
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9959
ER  - 

@article{
author = "Gavrilović, Ljubica and Popović, Nataša M. and Stojiljković, Vesna and Pejić, Snežana and Todorović, Ana and Pavlović, Ivan and Pantelić, Marija and Pajović, Snežana B.",
year = "2021",
abstract = "Data about the dynamics of noradrenaline (NA) transmission, storage and degradation may be very important for understanding the reduction of functional deficiency of NA and maintaining the stability of NA levels in animals with depressive-like behavior treated with lithium. This study aimed to investigate the effects of mood stabilizer lithium on concentrations of NA in the prefrontal cortex (PFC), as well as behavior rats exposed to chronic restraint stress (CRS). In addition, this study examined the effects of lithium on protein levels of noradrenaline transporter (NET), vesicular monoamine transporter 2 (VMAT2) and catechol-O-methyltransferase (COMT), as well as the enzyme activity of monoamine oxidase A (MOA) in the PFC of chronically stressed rats. METHODS: The investigated parameters were quantified by Western blot analysis, CAT Research ELISA kits, and an assay of enzyme activity. Also, the forced swim test (FST) was used to assess the behavior of animals. RESULTS: We found that lithium treatment decreased high protein levels of NET and VMAT2, as well as the enzyme activity of MOA in chronically stressed rats to the levels found in unstressed animals. In addition, lithium treatment decreased the concentration of NA (24%) and immobility in animals exposed to CRS. CONCLUSION: Our data confirm that lithium-induced modulation of prefrontal noradrenergic turnover and stabilized the behavior of chronically stressed rats.",
journal = "Neuroendocrinology Letters",
title = "Effects of mood stabilizer lithium on noradrenergic turnover in the prefrontal cortex of chronically stressed rats",
volume = "42",
number = "3",
pages = "171-176",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9959"
}

Gavrilović, L., Popović, N. M., Stojiljković, V., Pejić, S., Todorović, A., Pavlović, I., Pantelić, M.,& Pajović, S. B.. (2021). Effects of mood stabilizer lithium on noradrenergic turnover in the prefrontal cortex of chronically stressed rats. in Neuroendocrinology Letters, 42(3), 171-176.
https://hdl.handle.net/21.15107/rcub_vinar_9959

Gavrilović L, Popović NM, Stojiljković V, Pejić S, Todorović A, Pavlović I, Pantelić M, Pajović SB. Effects of mood stabilizer lithium on noradrenergic turnover in the prefrontal cortex of chronically stressed rats. in Neuroendocrinology Letters. 2021;42(3):171-176.
https://hdl.handle.net/21.15107/rcub_vinar_9959 .

Gavrilović, Ljubica, Popović, Nataša M., Stojiljković, Vesna, Pejić, Snežana, Todorović, Ana, Pavlović, Ivan, Pantelić, Marija, Pajović, Snežana B., "Effects of mood stabilizer lithium on noradrenergic turnover in the prefrontal cortex of chronically stressed rats" in Neuroendocrinology Letters, 42, no. 3 (2021):171-176,
https://hdl.handle.net/21.15107/rcub_vinar_9959 .

TY  - JOUR
AU  - Glumac, Sofija
AU  - Davidović, Radoslav S.
AU  - Dožić, Branko
AU  - Hinić, Sasa
AU  - Pavlović, Ivan
AU  - Drakulić, Dunja R.
AU  - Todorović, Ana
AU  - Medojević Pavlović, Maja
AU  - Radojević-Škodrić, Sanja
AU  - Baralić, Ivana
AU  - Sopta, Jelena
AU  - Pejić, Snežana
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9887
AB  - Rhabdomyosarcoma (RMS) is a highly malignant cancer and is the most common soft tissue sarcoma in children and adolescents, but it is rare in adults (<1% of all adult malignancies). Altered expression and molecular abnormalities of cell-cycle-regulatory proteins are one of the most prominent features in RMS. Therefore, we evaluated the expression of cyclin-dependent kinase inhibitors p57 and p16, as well as p16 methylation status, along with clinicopathological characteristics and overall survival (OS) in RMS patients. This analysis was conducted on 23 pediatric and 44 adult patients. There was a male predominance in both groups and extremities were the most frequent tumor site. In adults, alveolar and pleomorphic types were almost equally represented. The majority of pediatric tumors were low grade, whereas, in adults, only one patient had a low-grade tumor. Seven pediatric (30.43%) and eight adult (18.18%) patients had a low p16 expression. The analysis of methylation status of the p16 promoter showed the presence of methylated allele only in one sample with pleomorphic histology. Six (26.1%) pediatric and 15 (34.1%) adult patients had low p57 expression, while in 17 (73.9%) pediatric and 29 (65.9%) adult patients it was assessed as high. Ninetyone percent of the pediatric patients and 32.6% of adults were alive at the end of the observational period. In adults, significant associations were found between OS and age (P = 0.020), gender (P = 0.027), tumor size (P < 0.001), lymph node status (P < 0.001), presence of metastases (P = 0.015), and p57 expression (P = 0.039). Stratification by histological type showed the correlation of low p57 expression (P = 0.030) and worse OS of patients with alveolar RMS. Univariate analysis identified age > 50 yrs. (HR 2.447), tumors > 5 cm (HR 21.31), involvement of regional lymph nodes (HR 3.96), the presence of metastases (HR 2.53), and low p57 expression (HR 2.11) as predictors of lower OS. Tumor size, regional lymph nodes involvement, and metastases were the independent predictors after multivariate analysis, while p57 did not predict OS in an independent way. In summary, although p57 was not confirmed to be an independent predictor of OS, our results indicate that its low expression may be the marker of aggressive phenotype and poor prognosis in adult RMS patients. Also, our findings suggest that epigenetic inactivation of p16 is not important in the pathogenesis of rhabdomyosarcoma.
T2  - Pathology - Research and Practice
T1  - Immunohistochemical expression of cyclin-dependent kinase inhibitors p16 and p57 in rhabdomyosarcoma
VL  - 225
SP  - 153558
DO  - 10.1016/j.prp.2021.153558
ER  - 

@article{
author = "Glumac, Sofija and Davidović, Radoslav S. and Dožić, Branko and Hinić, Sasa and Pavlović, Ivan and Drakulić, Dunja R. and Todorović, Ana and Medojević Pavlović, Maja and Radojević-Škodrić, Sanja and Baralić, Ivana and Sopta, Jelena and Pejić, Snežana",
year = "2021",
abstract = "Rhabdomyosarcoma (RMS) is a highly malignant cancer and is the most common soft tissue sarcoma in children and adolescents, but it is rare in adults (<1% of all adult malignancies). Altered expression and molecular abnormalities of cell-cycle-regulatory proteins are one of the most prominent features in RMS. Therefore, we evaluated the expression of cyclin-dependent kinase inhibitors p57 and p16, as well as p16 methylation status, along with clinicopathological characteristics and overall survival (OS) in RMS patients. This analysis was conducted on 23 pediatric and 44 adult patients. There was a male predominance in both groups and extremities were the most frequent tumor site. In adults, alveolar and pleomorphic types were almost equally represented. The majority of pediatric tumors were low grade, whereas, in adults, only one patient had a low-grade tumor. Seven pediatric (30.43%) and eight adult (18.18%) patients had a low p16 expression. The analysis of methylation status of the p16 promoter showed the presence of methylated allele only in one sample with pleomorphic histology. Six (26.1%) pediatric and 15 (34.1%) adult patients had low p57 expression, while in 17 (73.9%) pediatric and 29 (65.9%) adult patients it was assessed as high. Ninetyone percent of the pediatric patients and 32.6% of adults were alive at the end of the observational period. In adults, significant associations were found between OS and age (P = 0.020), gender (P = 0.027), tumor size (P < 0.001), lymph node status (P < 0.001), presence of metastases (P = 0.015), and p57 expression (P = 0.039). Stratification by histological type showed the correlation of low p57 expression (P = 0.030) and worse OS of patients with alveolar RMS. Univariate analysis identified age > 50 yrs. (HR 2.447), tumors > 5 cm (HR 21.31), involvement of regional lymph nodes (HR 3.96), the presence of metastases (HR 2.53), and low p57 expression (HR 2.11) as predictors of lower OS. Tumor size, regional lymph nodes involvement, and metastases were the independent predictors after multivariate analysis, while p57 did not predict OS in an independent way. In summary, although p57 was not confirmed to be an independent predictor of OS, our results indicate that its low expression may be the marker of aggressive phenotype and poor prognosis in adult RMS patients. Also, our findings suggest that epigenetic inactivation of p16 is not important in the pathogenesis of rhabdomyosarcoma.",
journal = "Pathology - Research and Practice",
title = "Immunohistochemical expression of cyclin-dependent kinase inhibitors p16 and p57 in rhabdomyosarcoma",
volume = "225",
pages = "153558",
doi = "10.1016/j.prp.2021.153558"
}

Glumac, S., Davidović, R. S., Dožić, B., Hinić, S., Pavlović, I., Drakulić, D. R., Todorović, A., Medojević Pavlović, M., Radojević-Škodrić, S., Baralić, I., Sopta, J.,& Pejić, S.. (2021). Immunohistochemical expression of cyclin-dependent kinase inhibitors p16 and p57 in rhabdomyosarcoma. in Pathology - Research and Practice, 225, 153558.
https://doi.org/10.1016/j.prp.2021.153558

Glumac S, Davidović RS, Dožić B, Hinić S, Pavlović I, Drakulić DR, Todorović A, Medojević Pavlović M, Radojević-Škodrić S, Baralić I, Sopta J, Pejić S. Immunohistochemical expression of cyclin-dependent kinase inhibitors p16 and p57 in rhabdomyosarcoma. in Pathology - Research and Practice. 2021;225:153558.
doi:10.1016/j.prp.2021.153558 .

Glumac, Sofija, Davidović, Radoslav S., Dožić, Branko, Hinić, Sasa, Pavlović, Ivan, Drakulić, Dunja R., Todorović, Ana, Medojević Pavlović, Maja, Radojević-Škodrić, Sanja, Baralić, Ivana, Sopta, Jelena, Pejić, Snežana, "Immunohistochemical expression of cyclin-dependent kinase inhibitors p16 and p57 in rhabdomyosarcoma" in Pathology - Research and Practice, 225 (2021):153558,
https://doi.org/10.1016/j.prp.2021.153558 . .

TY  - CONF
AU  - Đorđević, Neda
AU  - Korićanac, Lela
AU  - Žakula, Jelena
AU  - Todorović Vukotić, Nevena
AU  - Pejić, Snežana
AU  - Tešević, V.
AU  - Pajović, Snežana B.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12583
AB  - Melanoma is responsible for 75% of all deaths from skin cancer. Its lethality arises from its rapid progression, easy metastasis and drug-resistance as well. Red wine is a natural product rich in polyphenolic compounds with potent anticancer activities. It seems that in cancer cells these compounds behave as prooxidants initiating reactive oxygen species mediated cellular DNA breakage and consequent cell death. The aim of this study was to investigate prooxidative activity of red wine samples (Merlot variety, commercial as well as VCR1 and VCR101 clonal wines) in melanoma A375 cells, through measuring the relationship of reduced and oxidized form of glutathione (GSH/GSSG) and comparison with the GSH/GSSG ratio in control (untreated melanoma cells). The data obtained showed that tested red wine samples decrease GSH/GSSG ratio in A375 cells compared to control (4.6 ± 0), with the largest decrease noticed in treatment with VCR101 wine (0.66 ± 0.05).
PB  - The Society of Physical Chemists of Serbia
C3  - 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume II, September 20-24
T1  - Examination of Prooxidative Activity of Red Wine in Melanoma Cells
SP  - 699
EP  - 702
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12583
ER  - 

@conference{
author = "Đorđević, Neda and Korićanac, Lela and Žakula, Jelena and Todorović Vukotić, Nevena and Pejić, Snežana and Tešević, V. and Pajović, Snežana B.",
year = "2021",
abstract = "Melanoma is responsible for 75% of all deaths from skin cancer. Its lethality arises from its rapid progression, easy metastasis and drug-resistance as well. Red wine is a natural product rich in polyphenolic compounds with potent anticancer activities. It seems that in cancer cells these compounds behave as prooxidants initiating reactive oxygen species mediated cellular DNA breakage and consequent cell death. The aim of this study was to investigate prooxidative activity of red wine samples (Merlot variety, commercial as well as VCR1 and VCR101 clonal wines) in melanoma A375 cells, through measuring the relationship of reduced and oxidized form of glutathione (GSH/GSSG) and comparison with the GSH/GSSG ratio in control (untreated melanoma cells). The data obtained showed that tested red wine samples decrease GSH/GSSG ratio in A375 cells compared to control (4.6 ± 0), with the largest decrease noticed in treatment with VCR101 wine (0.66 ± 0.05).",
publisher = "The Society of Physical Chemists of Serbia",
journal = "15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume II, September 20-24",
title = "Examination of Prooxidative Activity of Red Wine in Melanoma Cells",
pages = "699-702",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12583"
}

Đorđević, N., Korićanac, L., Žakula, J., Todorović Vukotić, N., Pejić, S., Tešević, V.,& Pajović, S. B.. (2021). Examination of Prooxidative Activity of Red Wine in Melanoma Cells. in 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume II, September 20-24
The Society of Physical Chemists of Serbia., 699-702.
https://hdl.handle.net/21.15107/rcub_vinar_12583

Đorđević N, Korićanac L, Žakula J, Todorović Vukotić N, Pejić S, Tešević V, Pajović SB. Examination of Prooxidative Activity of Red Wine in Melanoma Cells. in 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume II, September 20-24. 2021;:699-702.
https://hdl.handle.net/21.15107/rcub_vinar_12583 .

Đorđević, Neda, Korićanac, Lela, Žakula, Jelena, Todorović Vukotić, Nevena, Pejić, Snežana, Tešević, V., Pajović, Snežana B., "Examination of Prooxidative Activity of Red Wine in Melanoma Cells" in 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume II, September 20-24 (2021):699-702,
https://hdl.handle.net/21.15107/rcub_vinar_12583 .

TY  - CONF
AU  - Todorović, Ana
AU  - Drakulić, Dunja
AU  - Gavrilović, Ljubica
AU  - Stojiljković, Vesna
AU  - Popović, Nataša M.
AU  - Đorđević, Neda
AU  - Todorović Vukotić, Nevena
AU  - Miletić, J.
AU  - Pejić, Snežana
AU  - Pajović, Snežana B.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12580
AB  - The literature emphasizes the involvement of oxidative stress in the etiopathogenesis of many uterine diseases. Antioxidant system (AOS) represents the protective mechanism used by cells to neutralize overproduced reactive oxygen species (ROS) and prevent oxidative stress. We have previously shown that in gynecological patients with various diagnoses, the reproductive and other factors may be associated with antioxidant capacity and the ability to defend against oxidative damage. In this study, we examined the changes in expression of antioxidant enzymes (AOE): superoxide dismutases (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) in the blood of women with endometrial hyperplasia. Our results indicate that hyperplasia induces perturbance in oxidative balance, particularly in glutathione redox cycle enzymes.
PB  - The Society of Physical Chemists of Serbia
C3  - 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume I, September 20-24
T1  - Antioxidant Enzymes in Blood of Women With Uterine Hyperplasia
SP  - 308
EP  - 311
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12580
ER  - 

@conference{
author = "Todorović, Ana and Drakulić, Dunja and Gavrilović, Ljubica and Stojiljković, Vesna and Popović, Nataša M. and Đorđević, Neda and Todorović Vukotić, Nevena and Miletić, J. and Pejić, Snežana and Pajović, Snežana B.",
year = "2021",
abstract = "The literature emphasizes the involvement of oxidative stress in the etiopathogenesis of many uterine diseases. Antioxidant system (AOS) represents the protective mechanism used by cells to neutralize overproduced reactive oxygen species (ROS) and prevent oxidative stress. We have previously shown that in gynecological patients with various diagnoses, the reproductive and other factors may be associated with antioxidant capacity and the ability to defend against oxidative damage. In this study, we examined the changes in expression of antioxidant enzymes (AOE): superoxide dismutases (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) in the blood of women with endometrial hyperplasia. Our results indicate that hyperplasia induces perturbance in oxidative balance, particularly in glutathione redox cycle enzymes.",
publisher = "The Society of Physical Chemists of Serbia",
journal = "15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume I, September 20-24",
title = "Antioxidant Enzymes in Blood of Women With Uterine Hyperplasia",
pages = "308-311",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12580"
}

Todorović, A., Drakulić, D., Gavrilović, L., Stojiljković, V., Popović, N. M., Đorđević, N., Todorović Vukotić, N., Miletić, J., Pejić, S.,& Pajović, S. B.. (2021). Antioxidant Enzymes in Blood of Women With Uterine Hyperplasia. in 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume I, September 20-24
The Society of Physical Chemists of Serbia., 308-311.
https://hdl.handle.net/21.15107/rcub_vinar_12580

Todorović A, Drakulić D, Gavrilović L, Stojiljković V, Popović NM, Đorđević N, Todorović Vukotić N, Miletić J, Pejić S, Pajović SB. Antioxidant Enzymes in Blood of Women With Uterine Hyperplasia. in 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume I, September 20-24. 2021;:308-311.
https://hdl.handle.net/21.15107/rcub_vinar_12580 .

Todorović, Ana, Drakulić, Dunja, Gavrilović, Ljubica, Stojiljković, Vesna, Popović, Nataša M., Đorđević, Neda, Todorović Vukotić, Nevena, Miletić, J., Pejić, Snežana, Pajović, Snežana B., "Antioxidant Enzymes in Blood of Women With Uterine Hyperplasia" in 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry 2021 : proceedings, Volume I, September 20-24 (2021):308-311,
https://hdl.handle.net/21.15107/rcub_vinar_12580 .

TY  - JOUR
AU  - Todorović Vukotić, Nevena
AU  - Đorđević, Jelena
AU  - Pejić, Snežana
AU  - Đorđević, Neda O.
AU  - Pajović, Snežana B.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9078
AB  - Drug-induced liver injury (DILI) is a serious health burden. It has diverse clinical presentations that can escalate to acute liver failure. The worldwide increase in the use of psychotropic drugs, their long-term use on a daily basis, common comorbidities of psychiatric and metabolic disorders, and polypharmacy in psychiatric patients increase the incidence of psychotropics-induced DILI. During the last 2 decades, hepatotoxicity of various antidepressants (ADs) and antipsychotics (APs) received much attention. Comprehensive review and discussion of accumulated literature data concerning this issue are performed in this study, as hepatotoxic effects of most commonly prescribed ADs and APs are classified, described, and discussed. The review focuses on ADs and APs characterized by the risk of causing liver damage and highlights the ones found to cause life-threatening or severe DILI cases. In parallel, an overview of hepatic oxidative stress, inflammation, and steatosis underlying DILI is provided, followed by extensive review and discussion of the pathophysiology of AD- and AP-induced DILI revealed in case reports, and animal and in vitro studies. The consequences of some ADs and APs ability to affect drug-metabolizing enzymes and therefore provoke drug–drug interactions are also addressed. Continuous collecting of data on drugs, mechanisms, and risk factors for DILI, as well as critical data reviewing, is crucial for easier DILI diagnosis and more efficient risk assessment of AD- and AP-induced DILI. Higher awareness of ADs and APs hepatotoxicity is the prerequisite for their safe use and optimal dosing. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.
T2  - Archives of Toxicology
T1  - Antidepressants- and antipsychotics-induced hepatotoxicity
VL  - 95
IS  - 3
SP  - 767
EP  - 789
DO  - 10.1007/s00204-020-02963-4
ER  - 

@article{
author = "Todorović Vukotić, Nevena and Đorđević, Jelena and Pejić, Snežana and Đorđević, Neda O. and Pajović, Snežana B.",
year = "2021",
abstract = "Drug-induced liver injury (DILI) is a serious health burden. It has diverse clinical presentations that can escalate to acute liver failure. The worldwide increase in the use of psychotropic drugs, their long-term use on a daily basis, common comorbidities of psychiatric and metabolic disorders, and polypharmacy in psychiatric patients increase the incidence of psychotropics-induced DILI. During the last 2 decades, hepatotoxicity of various antidepressants (ADs) and antipsychotics (APs) received much attention. Comprehensive review and discussion of accumulated literature data concerning this issue are performed in this study, as hepatotoxic effects of most commonly prescribed ADs and APs are classified, described, and discussed. The review focuses on ADs and APs characterized by the risk of causing liver damage and highlights the ones found to cause life-threatening or severe DILI cases. In parallel, an overview of hepatic oxidative stress, inflammation, and steatosis underlying DILI is provided, followed by extensive review and discussion of the pathophysiology of AD- and AP-induced DILI revealed in case reports, and animal and in vitro studies. The consequences of some ADs and APs ability to affect drug-metabolizing enzymes and therefore provoke drug–drug interactions are also addressed. Continuous collecting of data on drugs, mechanisms, and risk factors for DILI, as well as critical data reviewing, is crucial for easier DILI diagnosis and more efficient risk assessment of AD- and AP-induced DILI. Higher awareness of ADs and APs hepatotoxicity is the prerequisite for their safe use and optimal dosing. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.",
journal = "Archives of Toxicology",
title = "Antidepressants- and antipsychotics-induced hepatotoxicity",
volume = "95",
number = "3",
pages = "767-789",
doi = "10.1007/s00204-020-02963-4"
}

Todorović Vukotić, N., Đorđević, J., Pejić, S., Đorđević, N. O.,& Pajović, S. B.. (2021). Antidepressants- and antipsychotics-induced hepatotoxicity. in Archives of Toxicology, 95(3), 767-789.
https://doi.org/10.1007/s00204-020-02963-4

Todorović Vukotić N, Đorđević J, Pejić S, Đorđević NO, Pajović SB. Antidepressants- and antipsychotics-induced hepatotoxicity. in Archives of Toxicology. 2021;95(3):767-789.
doi:10.1007/s00204-020-02963-4 .

Todorović Vukotić, Nevena, Đorđević, Jelena, Pejić, Snežana, Đorđević, Neda O., Pajović, Snežana B., "Antidepressants- and antipsychotics-induced hepatotoxicity" in Archives of Toxicology, 95, no. 3 (2021):767-789,
https://doi.org/10.1007/s00204-020-02963-4 . .