TY  - JOUR
AU  - Đorđević, Miloš
AU  - Fattori, Serena
AU  - Petringa, Giada
AU  - Ristić Fira, Aleksandra
AU  - Petrović, Ivan
AU  - Cuttone, Giacomo
AU  - Cirrone, G.A. Pablo
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12241
AB  - Purpose: The use of Monte Carlo (MC) simulations capable of reproducing radiobiological effects of ionising radiation on human cell lines is of great importance, especially for cases involving protons and heavier ion beams. In the latter, huge uncertainties can arise mainly related to the effects of the secondary particles produced in the beam-tissue interaction. This paper reports on a detailed MC study performed using Geant4-based approach on three cancer cell lines, the HTB-177, CRL-5876 and MCF-7, that were previously irradiated with therapeutic proton and carbon ion beams. Methods: A Geant4-based approach used jointly with analytical calculations has been developed to provide a more realistic estimation of the radiobiological damage produced by proton and carbon beams in tissues, reproducing available data obtained from in vitro cell irradiations. The MC “Hadrontherapy” Geant4 application and the Local Effect Model: LEM I, LEM II and LEM III coupled with the different numerical approaches: RapidRusso (RR) and RapidScholz (RS) were used in the study. Results: Experimental survival curves are compared with those evaluated using the highlighted Geant4 MC-based approach via chi-square statistical analysis, for the combinations of radiobiological models and numerical approaches, as outlined above. Conclusion: This study has presented a comparison of the survival data from MC simulations to experimental survival data for three cancer cell lines. An overall best level of agreement was obtained for the HTB-177 cells.
T2  - Physica Medica
T1  - Computational approaches in the estimation of radiobiological damage for human-malignant cells irradiated with clinical proton and carbon beams
VL  - 117
SP  - 103189
DO  - 10.1016/j.ejmp.2023.103189
ER  - 

@article{
author = "Đorđević, Miloš and Fattori, Serena and Petringa, Giada and Ristić Fira, Aleksandra and Petrović, Ivan and Cuttone, Giacomo and Cirrone, G.A. Pablo",
year = "2024",
abstract = "Purpose: The use of Monte Carlo (MC) simulations capable of reproducing radiobiological effects of ionising radiation on human cell lines is of great importance, especially for cases involving protons and heavier ion beams. In the latter, huge uncertainties can arise mainly related to the effects of the secondary particles produced in the beam-tissue interaction. This paper reports on a detailed MC study performed using Geant4-based approach on three cancer cell lines, the HTB-177, CRL-5876 and MCF-7, that were previously irradiated with therapeutic proton and carbon ion beams. Methods: A Geant4-based approach used jointly with analytical calculations has been developed to provide a more realistic estimation of the radiobiological damage produced by proton and carbon beams in tissues, reproducing available data obtained from in vitro cell irradiations. The MC “Hadrontherapy” Geant4 application and the Local Effect Model: LEM I, LEM II and LEM III coupled with the different numerical approaches: RapidRusso (RR) and RapidScholz (RS) were used in the study. Results: Experimental survival curves are compared with those evaluated using the highlighted Geant4 MC-based approach via chi-square statistical analysis, for the combinations of radiobiological models and numerical approaches, as outlined above. Conclusion: This study has presented a comparison of the survival data from MC simulations to experimental survival data for three cancer cell lines. An overall best level of agreement was obtained for the HTB-177 cells.",
journal = "Physica Medica",
title = "Computational approaches in the estimation of radiobiological damage for human-malignant cells irradiated with clinical proton and carbon beams",
volume = "117",
pages = "103189",
doi = "10.1016/j.ejmp.2023.103189"
}

Đorđević, M., Fattori, S., Petringa, G., Ristić Fira, A., Petrović, I., Cuttone, G.,& Cirrone, G.A. P.. (2024). Computational approaches in the estimation of radiobiological damage for human-malignant cells irradiated with clinical proton and carbon beams. in Physica Medica, 117, 103189.
https://doi.org/10.1016/j.ejmp.2023.103189

Đorđević M, Fattori S, Petringa G, Ristić Fira A, Petrović I, Cuttone G, Cirrone GP. Computational approaches in the estimation of radiobiological damage for human-malignant cells irradiated with clinical proton and carbon beams. in Physica Medica. 2024;117:103189.
doi:10.1016/j.ejmp.2023.103189 .

Đorđević, Miloš, Fattori, Serena, Petringa, Giada, Ristić Fira, Aleksandra, Petrović, Ivan, Cuttone, Giacomo, Cirrone, G.A. Pablo, "Computational approaches in the estimation of radiobiological damage for human-malignant cells irradiated with clinical proton and carbon beams" in Physica Medica, 117 (2024):103189,
https://doi.org/10.1016/j.ejmp.2023.103189 . .

TY  - JOUR
AU  - Fattori, Serena
AU  - Petringa, Giada
AU  - Agosteo, Stefano
AU  - Bortot, Davide
AU  - Conte, Valeria
AU  - Cuttone, Giacomo
AU  - Di Fini, Andrea
AU  - Farokhi, Fatemeh
AU  - Mazzucconi, Davide
AU  - Pandola, Luciano
AU  - Petrović, Ivan M.
AU  - Ristić-Fira, Aleksandra
AU  - Rosenfeld, Anatoly
AU  - Weber, Uli
AU  - Cirrone, Giuseppe Pablo
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10393
AB  - In the present hadrontherapy scenario, there is a growing interest in exploring the capabilities of different ion species other than protons and carbons. The possibility of using different ions paves the way for new radiotherapy approaches, such as the multi-ions treatment, where radiation could vary according to target volume, shape, depth and histologic characteristics of the tumor. For these reasons, in this paper, the study and understanding of biological-relevant quantities was extended for the case of 4He ion. Approach. Geant4 Monte Carlo based algorithms for dose- and track-averaged LET (Linear Energy Transfer) calculations, were validated for 4He ions and for the case of a mixed field characterised by the presence of secondary ions from both target and projectile fragmentation. The simulated dose and track averaged LETs were compared with the corresponding dose and frequency mean values of the lineal energy, and , derived from experimental microdosimetric spectra. Two microdosimetric experimental campaigns were carried out at the Italian eye proton therapy facility of the Laboratori Nazionali del Sud of Istituto Nazionale di Fisica Nucleare (INFN-LNS, Catania, I) using two different microdosimeters: the MicroPlus probe and the nano-TEPC (Tissue Equivalent Proportional Counter). Main results. A good agreement of and with and experimentally measured with both microdosimetric detectors MicroPlus and nano-TEPC in two configurations: full energy and modulated 4He ion beam, was found. Significance. The results of this study certify the use of a very effective tool for the precise calculation of LET, given by a Monte Carlo approach which has the advantage of allowing detailed simulation and tracking of nuclear interactions, even in complex clinical scenarios.
T2  - Physics in Medicine & Biology
T1  - 4He dose- and track-averaged linear energy transfer: Monte Carlo algorithms and experimental verification
VL  - 67
IS  - 16
SP  - 165003
DO  - 10.1088/1361-6560/ac776f
ER  - 

@article{
author = "Fattori, Serena and Petringa, Giada and Agosteo, Stefano and Bortot, Davide and Conte, Valeria and Cuttone, Giacomo and Di Fini, Andrea and Farokhi, Fatemeh and Mazzucconi, Davide and Pandola, Luciano and Petrović, Ivan M. and Ristić-Fira, Aleksandra and Rosenfeld, Anatoly and Weber, Uli and Cirrone, Giuseppe Pablo",
year = "2022",
abstract = "In the present hadrontherapy scenario, there is a growing interest in exploring the capabilities of different ion species other than protons and carbons. The possibility of using different ions paves the way for new radiotherapy approaches, such as the multi-ions treatment, where radiation could vary according to target volume, shape, depth and histologic characteristics of the tumor. For these reasons, in this paper, the study and understanding of biological-relevant quantities was extended for the case of 4He ion. Approach. Geant4 Monte Carlo based algorithms for dose- and track-averaged LET (Linear Energy Transfer) calculations, were validated for 4He ions and for the case of a mixed field characterised by the presence of secondary ions from both target and projectile fragmentation. The simulated dose and track averaged LETs were compared with the corresponding dose and frequency mean values of the lineal energy, and , derived from experimental microdosimetric spectra. Two microdosimetric experimental campaigns were carried out at the Italian eye proton therapy facility of the Laboratori Nazionali del Sud of Istituto Nazionale di Fisica Nucleare (INFN-LNS, Catania, I) using two different microdosimeters: the MicroPlus probe and the nano-TEPC (Tissue Equivalent Proportional Counter). Main results. A good agreement of and with and experimentally measured with both microdosimetric detectors MicroPlus and nano-TEPC in two configurations: full energy and modulated 4He ion beam, was found. Significance. The results of this study certify the use of a very effective tool for the precise calculation of LET, given by a Monte Carlo approach which has the advantage of allowing detailed simulation and tracking of nuclear interactions, even in complex clinical scenarios.",
journal = "Physics in Medicine & Biology",
title = "4He dose- and track-averaged linear energy transfer: Monte Carlo algorithms and experimental verification",
volume = "67",
number = "16",
pages = "165003",
doi = "10.1088/1361-6560/ac776f"
}

Fattori, S., Petringa, G., Agosteo, S., Bortot, D., Conte, V., Cuttone, G., Di Fini, A., Farokhi, F., Mazzucconi, D., Pandola, L., Petrović, I. M., Ristić-Fira, A., Rosenfeld, A., Weber, U.,& Cirrone, G. P.. (2022). 4He dose- and track-averaged linear energy transfer: Monte Carlo algorithms and experimental verification. in Physics in Medicine & Biology, 67(16), 165003.
https://doi.org/10.1088/1361-6560/ac776f

Fattori S, Petringa G, Agosteo S, Bortot D, Conte V, Cuttone G, Di Fini A, Farokhi F, Mazzucconi D, Pandola L, Petrović IM, Ristić-Fira A, Rosenfeld A, Weber U, Cirrone GP. 4He dose- and track-averaged linear energy transfer: Monte Carlo algorithms and experimental verification. in Physics in Medicine & Biology. 2022;67(16):165003.
doi:10.1088/1361-6560/ac776f .

Fattori, Serena, Petringa, Giada, Agosteo, Stefano, Bortot, Davide, Conte, Valeria, Cuttone, Giacomo, Di Fini, Andrea, Farokhi, Fatemeh, Mazzucconi, Davide, Pandola, Luciano, Petrović, Ivan M., Ristić-Fira, Aleksandra, Rosenfeld, Anatoly, Weber, Uli, Cirrone, Giuseppe Pablo, "4He dose- and track-averaged linear energy transfer: Monte Carlo algorithms and experimental verification" in Physics in Medicine & Biology, 67, no. 16 (2022):165003,
https://doi.org/10.1088/1361-6560/ac776f . .

TY  - JOUR
AU  - Fattori, Serena
AU  - Petringa, Giada
AU  - Agosteo, Stefano
AU  - Bortot, Davide
AU  - Conte, Valeria
AU  - Cuttone, Giacomo
AU  - Di Fini, Andrea
AU  - Farokhi, Fatemeh
AU  - Mazzucconi, Davide
AU  - Pandola, Luciano
AU  - Petrović, Ivan M.
AU  - Ristić-Fira, Aleksandra
AU  - Rosenfeld, Anatoly
AU  - Weber, Uli
AU  - Cirrone, Giuseppe Pablo
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10586
AB  - In the present hadrontherapy scenario, there is a growing interest in exploring the capabilities of different ion species other than protons and carbons. The possibility of using different ions paves the way for new radiotherapy approaches, such as the multi-ions treatment, where radiation could vary according to target volume, shape, depth and histologic characteristics of the tumor. For these reasons, in this paper, the study and understanding of biological-relevant quantities was extended for the case of 4He ion. Approach. Geant4 Monte Carlo based algorithms for dose- and track-averaged LET (Linear Energy Transfer) calculations, were validated for 4He ions and for the case of a mixed field characterised by the presence of secondary ions from both target and projectile fragmentation. The simulated dose and track averaged LETs were compared with the corresponding dose and frequency mean values of the lineal energy, and , derived from experimental microdosimetric spectra. Two microdosimetric experimental campaigns were carried out at the Italian eye proton therapy facility of the Laboratori Nazionali del Sud of Istituto Nazionale di Fisica Nucleare (INFN-LNS, Catania, I) using two different microdosimeters: the MicroPlus probe and the nano-TEPC (Tissue Equivalent Proportional Counter). Main results. A good agreement of and with and experimentally measured with both microdosimetric detectors MicroPlus and nano-TEPC in two configurations: full energy and modulated 4He ion beam, was found. Significance. The results of this study certify the use of a very effective tool for the precise calculation of LET, given by a Monte Carlo approach which has the advantage of allowing detailed simulation and tracking of nuclear interactions, even in complex clinical scenarios.
T2  - Physics in Medicine & Biology
T1  - 4He dose- and track-averaged linear energy transfer: Monte Carlo algorithms and experimental verification
VL  - 67
IS  - 16
SP  - 165003
DO  - 10.1088/1361-6560/ac776f
ER  - 

@article{
author = "Fattori, Serena and Petringa, Giada and Agosteo, Stefano and Bortot, Davide and Conte, Valeria and Cuttone, Giacomo and Di Fini, Andrea and Farokhi, Fatemeh and Mazzucconi, Davide and Pandola, Luciano and Petrović, Ivan M. and Ristić-Fira, Aleksandra and Rosenfeld, Anatoly and Weber, Uli and Cirrone, Giuseppe Pablo",
year = "2022",
abstract = "In the present hadrontherapy scenario, there is a growing interest in exploring the capabilities of different ion species other than protons and carbons. The possibility of using different ions paves the way for new radiotherapy approaches, such as the multi-ions treatment, where radiation could vary according to target volume, shape, depth and histologic characteristics of the tumor. For these reasons, in this paper, the study and understanding of biological-relevant quantities was extended for the case of 4He ion. Approach. Geant4 Monte Carlo based algorithms for dose- and track-averaged LET (Linear Energy Transfer) calculations, were validated for 4He ions and for the case of a mixed field characterised by the presence of secondary ions from both target and projectile fragmentation. The simulated dose and track averaged LETs were compared with the corresponding dose and frequency mean values of the lineal energy, and , derived from experimental microdosimetric spectra. Two microdosimetric experimental campaigns were carried out at the Italian eye proton therapy facility of the Laboratori Nazionali del Sud of Istituto Nazionale di Fisica Nucleare (INFN-LNS, Catania, I) using two different microdosimeters: the MicroPlus probe and the nano-TEPC (Tissue Equivalent Proportional Counter). Main results. A good agreement of and with and experimentally measured with both microdosimetric detectors MicroPlus and nano-TEPC in two configurations: full energy and modulated 4He ion beam, was found. Significance. The results of this study certify the use of a very effective tool for the precise calculation of LET, given by a Monte Carlo approach which has the advantage of allowing detailed simulation and tracking of nuclear interactions, even in complex clinical scenarios.",
journal = "Physics in Medicine & Biology",
title = "4He dose- and track-averaged linear energy transfer: Monte Carlo algorithms and experimental verification",
volume = "67",
number = "16",
pages = "165003",
doi = "10.1088/1361-6560/ac776f"
}

Fattori, S., Petringa, G., Agosteo, S., Bortot, D., Conte, V., Cuttone, G., Di Fini, A., Farokhi, F., Mazzucconi, D., Pandola, L., Petrović, I. M., Ristić-Fira, A., Rosenfeld, A., Weber, U.,& Cirrone, G. P.. (2022). 4He dose- and track-averaged linear energy transfer: Monte Carlo algorithms and experimental verification. in Physics in Medicine & Biology, 67(16), 165003.
https://doi.org/10.1088/1361-6560/ac776f

Fattori S, Petringa G, Agosteo S, Bortot D, Conte V, Cuttone G, Di Fini A, Farokhi F, Mazzucconi D, Pandola L, Petrović IM, Ristić-Fira A, Rosenfeld A, Weber U, Cirrone GP. 4He dose- and track-averaged linear energy transfer: Monte Carlo algorithms and experimental verification. in Physics in Medicine & Biology. 2022;67(16):165003.
doi:10.1088/1361-6560/ac776f .

Fattori, Serena, Petringa, Giada, Agosteo, Stefano, Bortot, Davide, Conte, Valeria, Cuttone, Giacomo, Di Fini, Andrea, Farokhi, Fatemeh, Mazzucconi, Davide, Pandola, Luciano, Petrović, Ivan M., Ristić-Fira, Aleksandra, Rosenfeld, Anatoly, Weber, Uli, Cirrone, Giuseppe Pablo, "4He dose- and track-averaged linear energy transfer: Monte Carlo algorithms and experimental verification" in Physics in Medicine & Biology, 67, no. 16 (2022):165003,
https://doi.org/10.1088/1361-6560/ac776f . .