TY  - JOUR
AU  - Matić, Tamara
AU  - Zebić, M. Ležaja
AU  - Miletić, Vesna
AU  - Cvijović-Alagić, Ivana
AU  - Petrović, Rada D.
AU  - Janaćković, Đorđe T.
AU  - Veljović, Đorđe N.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10114
AB  - The aim of this study was to investigate the influence of binary Sr, Mg ion-doping compared to the single-ion doping effects on the phase composition and morphology of hydrothermally obtained calcium hydroxyapatite (HAP) powders and on the phase composition, microstructure, and mechanical properties of the sintered materials. Additionally, the focus of this study was to investigate the possible utilization of the binary doped Sr,Mg-HAP compacts as dentin substitutes in restorative dentistry by evaluating their bonding ability with commercially available restorative materials using the shear bond strength test (SBS). The hydrothermally obtained mono-doped Mg5 and Sr5 showed the monophasic apatite structure, while in all co-doped samples β-TCP phase was formed, resulting in biphasic calcium phosphate (BCP) powders. It was confirmed that co-doping with Sr and Mg ions led to the thermal stabilization of the β-TCP phase by suppressing the phase transition into α-TCP when sintered at 1200 °C. Moreover, the co-presence of Mg ions significantly improved the hardness of Sr-doped HAP from 3.74 to 5.02 GPa. Sr,Mg-HAP dental inserts were found to achieve sufficient bonding (13.53 MPa) through the micromechanical interlocking with Z250 dental composite and Single Bond Universal dental adhesive applied with a total etch approach. The SBS values obtained for the SrMg-HAP insert were similar to the literature data on bonding ability with human dentin, indicating that binary doped Sr,Mg-HAP ceramics present a promising material for application in restorative dentistry as dentin substitutes.
T2  - Ceramics International
T1  - Sr,Mg co-doping of calcium hydroxyapatite: Hydrothermal synthesis, processing, characterization and possible application as dentin substitutes
DO  - 10.1016/j.ceramint.2021.12.335
ER  - 

@article{
author = "Matić, Tamara and Zebić, M. Ležaja and Miletić, Vesna and Cvijović-Alagić, Ivana and Petrović, Rada D. and Janaćković, Đorđe T. and Veljović, Đorđe N.",
year = "2022",
abstract = "The aim of this study was to investigate the influence of binary Sr, Mg ion-doping compared to the single-ion doping effects on the phase composition and morphology of hydrothermally obtained calcium hydroxyapatite (HAP) powders and on the phase composition, microstructure, and mechanical properties of the sintered materials. Additionally, the focus of this study was to investigate the possible utilization of the binary doped Sr,Mg-HAP compacts as dentin substitutes in restorative dentistry by evaluating their bonding ability with commercially available restorative materials using the shear bond strength test (SBS). The hydrothermally obtained mono-doped Mg5 and Sr5 showed the monophasic apatite structure, while in all co-doped samples β-TCP phase was formed, resulting in biphasic calcium phosphate (BCP) powders. It was confirmed that co-doping with Sr and Mg ions led to the thermal stabilization of the β-TCP phase by suppressing the phase transition into α-TCP when sintered at 1200 °C. Moreover, the co-presence of Mg ions significantly improved the hardness of Sr-doped HAP from 3.74 to 5.02 GPa. Sr,Mg-HAP dental inserts were found to achieve sufficient bonding (13.53 MPa) through the micromechanical interlocking with Z250 dental composite and Single Bond Universal dental adhesive applied with a total etch approach. The SBS values obtained for the SrMg-HAP insert were similar to the literature data on bonding ability with human dentin, indicating that binary doped Sr,Mg-HAP ceramics present a promising material for application in restorative dentistry as dentin substitutes.",
journal = "Ceramics International",
title = "Sr,Mg co-doping of calcium hydroxyapatite: Hydrothermal synthesis, processing, characterization and possible application as dentin substitutes",
doi = "10.1016/j.ceramint.2021.12.335"
}

Matić, T., Zebić, M. L., Miletić, V., Cvijović-Alagić, I., Petrović, R. D., Janaćković, Đ. T.,& Veljović, Đ. N.. (2022). Sr,Mg co-doping of calcium hydroxyapatite: Hydrothermal synthesis, processing, characterization and possible application as dentin substitutes. in Ceramics International.
https://doi.org/10.1016/j.ceramint.2021.12.335

Matić T, Zebić ML, Miletić V, Cvijović-Alagić I, Petrović RD, Janaćković ĐT, Veljović ĐN. Sr,Mg co-doping of calcium hydroxyapatite: Hydrothermal synthesis, processing, characterization and possible application as dentin substitutes. in Ceramics International. 2022;.
doi:10.1016/j.ceramint.2021.12.335 .

Matić, Tamara, Zebić, M. Ležaja, Miletić, Vesna, Cvijović-Alagić, Ivana, Petrović, Rada D., Janaćković, Đorđe T., Veljović, Đorđe N., "Sr,Mg co-doping of calcium hydroxyapatite: Hydrothermal synthesis, processing, characterization and possible application as dentin substitutes" in Ceramics International (2022),
https://doi.org/10.1016/j.ceramint.2021.12.335 . .

TY  - JOUR
AU  - Manojlović, Dragica
AU  - Dramićanin, Miroslav
AU  - Miletić, Vesna
AU  - Mitić-Ćulafić, Dragana
AU  - Jovanović, Bojana
AU  - Nikolić, Biljana
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1462
AB  - Objective. To compare cytotoxicity and genotoxicity of novel urethane-based monomer FIT-852 and monoacylphosphine oxide photoinitiator (Lucirin TPO) with conventional Bisphenol A-glycidyl-methacrylate (BisGMA) and triethylene glycol dimethacrylate (TEGDMA) monomers and camphorquinone (CQ)/amine photoinitiator system, respectively. Moreover, we quantified and analyzed the combinatorial effects of individual substances in resin-based mixtures concerning the nature of the combinatorial effects. Methods. Cytotoxic and genotoxic effects of BisGMA, FIT, TEGDMA, CQ DMAEMA and TPO and their combined toxicity in four clinically relevant mixtures (FIT/TPO, FIT/CQ BisGMA/TPO, BisGMA/CQ) were tested on human fetal lung fibroblasts MRC-5 using MTT and Comet assays. We assessed combination effects of monomers and photoinitiators on overall toxicity from the measured concentration-effect relationships. Combination index (CI) was calculated on the basis of the median-effect equation derived from the mass-action law principle. Results. Individual substances showed decreasing cytotoxic effects in the following order: BisGMA GT TPO GT FIT GT CQ GT DMAEMA GT TEGDMA. Experimental mixtures showed decreasing cytotoxic effects in the order BisGMA/TPO GT BisGMA/CQ GT FIT/CQ GT FIT/TPO. FIT-based mixtures exhibited antagonistic cytotoxic effects between components while BisGMA-based mixtures demonstrated synergistic effects at ED50 TPO amplified both antagonistic and synergistic cytotoxic effects in mixtures. Pure substances showed genotoxicity in the following order: TPO GT BisGMA GT FIT GT CQ GT TEGDMA. We did not detect the genotoxic potential of DMAEMA. The rank of genotoxic concentrations of the mixtures was: BisGMA/TPO GT BisGMA/CQ GT FIT/CQ GT FIT/TPO. Significance. Lower cytotoxicity and genotoxicity of FIT than BisGMA suggests its greater bio-co mpatibility. Conversely, photoinitiator TPO was significantly more cytotoxic and genotoxic than both CQ and DMAEMA. CI values showed that components of FIT-based mixtures exhibit an antagonistic cytotoxic effect, while compontents of BisGMA-based mixtures show synergism.
T2  - Dental Materials
T1  - Cytotoxicity and genotoxicity of a low-shrinkage monomer and monoacylphosphine oxide photoinitiator: Comparative analyses of individual toxicity and combination effects in mixtures
VL  - 33
IS  - 4
SP  - 454
EP  - 466
DO  - 10.1016/j.dental.2017.02.002
ER  - 

@article{
author = "Manojlović, Dragica and Dramićanin, Miroslav and Miletić, Vesna and Mitić-Ćulafić, Dragana and Jovanović, Bojana and Nikolić, Biljana",
year = "2017",
abstract = "Objective. To compare cytotoxicity and genotoxicity of novel urethane-based monomer FIT-852 and monoacylphosphine oxide photoinitiator (Lucirin TPO) with conventional Bisphenol A-glycidyl-methacrylate (BisGMA) and triethylene glycol dimethacrylate (TEGDMA) monomers and camphorquinone (CQ)/amine photoinitiator system, respectively. Moreover, we quantified and analyzed the combinatorial effects of individual substances in resin-based mixtures concerning the nature of the combinatorial effects. Methods. Cytotoxic and genotoxic effects of BisGMA, FIT, TEGDMA, CQ DMAEMA and TPO and their combined toxicity in four clinically relevant mixtures (FIT/TPO, FIT/CQ BisGMA/TPO, BisGMA/CQ) were tested on human fetal lung fibroblasts MRC-5 using MTT and Comet assays. We assessed combination effects of monomers and photoinitiators on overall toxicity from the measured concentration-effect relationships. Combination index (CI) was calculated on the basis of the median-effect equation derived from the mass-action law principle. Results. Individual substances showed decreasing cytotoxic effects in the following order: BisGMA GT TPO GT FIT GT CQ GT DMAEMA GT TEGDMA. Experimental mixtures showed decreasing cytotoxic effects in the order BisGMA/TPO GT BisGMA/CQ GT FIT/CQ GT FIT/TPO. FIT-based mixtures exhibited antagonistic cytotoxic effects between components while BisGMA-based mixtures demonstrated synergistic effects at ED50 TPO amplified both antagonistic and synergistic cytotoxic effects in mixtures. Pure substances showed genotoxicity in the following order: TPO GT BisGMA GT FIT GT CQ GT TEGDMA. We did not detect the genotoxic potential of DMAEMA. The rank of genotoxic concentrations of the mixtures was: BisGMA/TPO GT BisGMA/CQ GT FIT/CQ GT FIT/TPO. Significance. Lower cytotoxicity and genotoxicity of FIT than BisGMA suggests its greater bio-co mpatibility. Conversely, photoinitiator TPO was significantly more cytotoxic and genotoxic than both CQ and DMAEMA. CI values showed that components of FIT-based mixtures exhibit an antagonistic cytotoxic effect, while compontents of BisGMA-based mixtures show synergism.",
journal = "Dental Materials",
title = "Cytotoxicity and genotoxicity of a low-shrinkage monomer and monoacylphosphine oxide photoinitiator: Comparative analyses of individual toxicity and combination effects in mixtures",
volume = "33",
number = "4",
pages = "454-466",
doi = "10.1016/j.dental.2017.02.002"
}

Manojlović, D., Dramićanin, M., Miletić, V., Mitić-Ćulafić, D., Jovanović, B.,& Nikolić, B.. (2017). Cytotoxicity and genotoxicity of a low-shrinkage monomer and monoacylphosphine oxide photoinitiator: Comparative analyses of individual toxicity and combination effects in mixtures. in Dental Materials, 33(4), 454-466.
https://doi.org/10.1016/j.dental.2017.02.002

Manojlović D, Dramićanin M, Miletić V, Mitić-Ćulafić D, Jovanović B, Nikolić B. Cytotoxicity and genotoxicity of a low-shrinkage monomer and monoacylphosphine oxide photoinitiator: Comparative analyses of individual toxicity and combination effects in mixtures. in Dental Materials. 2017;33(4):454-466.
doi:10.1016/j.dental.2017.02.002 .

Manojlović, Dragica, Dramićanin, Miroslav, Miletić, Vesna, Mitić-Ćulafić, Dragana, Jovanović, Bojana, Nikolić, Biljana, "Cytotoxicity and genotoxicity of a low-shrinkage monomer and monoacylphosphine oxide photoinitiator: Comparative analyses of individual toxicity and combination effects in mixtures" in Dental Materials, 33, no. 4 (2017):454-466,
https://doi.org/10.1016/j.dental.2017.02.002 . .

TY  - JOUR
AU  - Miletić, Vesna
AU  - Jakovljević, Nikola
AU  - Manojlović, Dragica
AU  - Marjanović, Jovana
AU  - Rosić, Aleksandra
AU  - Dramićanin, Miroslav
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1357
AB  - This study correlated the refractive indices (RIs) of unfilled resin mixtures and resin-based composites (RBCs) with color and translucency of conventional and low-shrinkage RBCs. Unfilled resin mixtures based on different ratios of conventional monomers Bisphenol A-glycidyl-methacrylate (BisGMA)/triethyleneglycol-dimethacrylate (TEGDMA) and urethane-dimethacrylate (UDMA)/TEGDMA and a low-shrinkage monomer FIT-852 (FIT, Esstech Inc.)/TEGDMA were used to prepare model RBCs, containing 30 wt % of the organic matrix and 70 wt % of silanated barium-glass fillers (n=1.553, Esstech Inc.). The RIs of resins were measured on an ABBE refractometer, those of cured RBCs using the Becke-line method in immersion oils. Color and translucency were determined using an AvaSpec-2048 (Avantes BV) spectrometer. The RIs of unfilled resin mixtures decreased with increasing amounts of TEGDMA. Cured RBCs had higher RIs than their respective resin mixtures. BisGMA-based composites were more translucent with significantly lower L* values than FIT- and UDMA-based RBCs. The RIs of unfilled resins positively correlated with cured RBCs (p=0.001), as did the RIs with translucency (p=0.001) and color (p=0.008). Resin mixtures and corresponding RBCs based on UDMA and its modified low-shrinkage version, FIT, showed similar optical properties. The RIs of unfilled resins appeared to be good predictors of the RIs of cured RBCs. (c) 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 7-13, 2017.
T2  - Journal of Biomedical Materials Research. Part B: Applied Biomaterials
T1  - Refractive indices of unfilled resin mixtures and cured composites related to color and translucency of conventional and low-shrinkage composites
VL  - 105
IS  - 1
SP  - 7
EP  - 13
DO  - 10.1002/jbm.b.33523
ER  - 

@article{
author = "Miletić, Vesna and Jakovljević, Nikola and Manojlović, Dragica and Marjanović, Jovana and Rosić, Aleksandra and Dramićanin, Miroslav",
year = "2017",
abstract = "This study correlated the refractive indices (RIs) of unfilled resin mixtures and resin-based composites (RBCs) with color and translucency of conventional and low-shrinkage RBCs. Unfilled resin mixtures based on different ratios of conventional monomers Bisphenol A-glycidyl-methacrylate (BisGMA)/triethyleneglycol-dimethacrylate (TEGDMA) and urethane-dimethacrylate (UDMA)/TEGDMA and a low-shrinkage monomer FIT-852 (FIT, Esstech Inc.)/TEGDMA were used to prepare model RBCs, containing 30 wt % of the organic matrix and 70 wt % of silanated barium-glass fillers (n=1.553, Esstech Inc.). The RIs of resins were measured on an ABBE refractometer, those of cured RBCs using the Becke-line method in immersion oils. Color and translucency were determined using an AvaSpec-2048 (Avantes BV) spectrometer. The RIs of unfilled resin mixtures decreased with increasing amounts of TEGDMA. Cured RBCs had higher RIs than their respective resin mixtures. BisGMA-based composites were more translucent with significantly lower L* values than FIT- and UDMA-based RBCs. The RIs of unfilled resins positively correlated with cured RBCs (p=0.001), as did the RIs with translucency (p=0.001) and color (p=0.008). Resin mixtures and corresponding RBCs based on UDMA and its modified low-shrinkage version, FIT, showed similar optical properties. The RIs of unfilled resins appeared to be good predictors of the RIs of cured RBCs. (c) 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 7-13, 2017.",
journal = "Journal of Biomedical Materials Research. Part B: Applied Biomaterials",
title = "Refractive indices of unfilled resin mixtures and cured composites related to color and translucency of conventional and low-shrinkage composites",
volume = "105",
number = "1",
pages = "7-13",
doi = "10.1002/jbm.b.33523"
}

Miletić, V., Jakovljević, N., Manojlović, D., Marjanović, J., Rosić, A.,& Dramićanin, M.. (2017). Refractive indices of unfilled resin mixtures and cured composites related to color and translucency of conventional and low-shrinkage composites. in Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 105(1), 7-13.
https://doi.org/10.1002/jbm.b.33523

Miletić V, Jakovljević N, Manojlović D, Marjanović J, Rosić A, Dramićanin M. Refractive indices of unfilled resin mixtures and cured composites related to color and translucency of conventional and low-shrinkage composites. in Journal of Biomedical Materials Research. Part B: Applied Biomaterials. 2017;105(1):7-13.
doi:10.1002/jbm.b.33523 .

Miletić, Vesna, Jakovljević, Nikola, Manojlović, Dragica, Marjanović, Jovana, Rosić, Aleksandra, Dramićanin, Miroslav, "Refractive indices of unfilled resin mixtures and cured composites related to color and translucency of conventional and low-shrinkage composites" in Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 105, no. 1 (2017):7-13,
https://doi.org/10.1002/jbm.b.33523 . .

TY  - JOUR
AU  - Manojlović, Dragica
AU  - Dramićanin, Miroslav
AU  - Milošević, Miloš
AU  - Zeković, Ivana Lj.
AU  - Cvijović-Alagić, Ivana
AU  - Mitrović, Nenad
AU  - Miletić, Vesna
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/798
AB  - This study investigated the degree of conversion, depth of cure, Vickers hardness, flexural strength, flexural modulus and volumetric shrinkage of experimental composite containing a low shrinkage monomer FIT-852 (FIT; Esstech Inc.) and photoinitiator 2,4,6-trimethylbenzoyldiphenylphosphine oxide (TPO; Sigma Aldrich) compared to conventional composite containing Bisphenol A-glycidyl methacrylate (BisGMA) and camphorquinone-amine photoinitiator system. The degree of conversion was generally higher in FIT-based composites (45-64% range) than in BisGMA-based composites (34-58% range). Vickers hardness, flexural strength and modulus were higher in BisGMA-based composites. A polywave light-curing unit was generally more efficient in terms of conversion and hardness of experimental composites than a monowave unit. FIT-based composite containing TPO showed the depth of cure below 2 mm irrespective of the curing light. The depth of cure of FIT-based composite containing CQ and BisGMA-based composites with either photoinitiator was in the range of 2.8-3.0 mm. Volumetric shrinkage of FIT-based composite (0.9-5.7% range) was lower than that of BisGMA-based composite (2.2-12% range). FIT may be used as a shrinkage reducing monomer compatible with the conventional CQ-amine system as well as the alternative TPO photoinitiator. However, the depth of cure of FIT_TPO composite requires boosting to achieve clinically recommended thickness of 2 mm. (C) 2015 Elsevier B.V. All rights reserved.
T2  - Materials Science and Engineering. C: Materials for Biological Applications
T1  - Effects of a low-Shrinkage methacrylate monomer and monoacylphosphine oxide photoinitiator on curing efficiency and mechanical properties of experimental resin-based composites
VL  - 58
SP  - 487
EP  - 494
DO  - 10.1016/j.msec.2015.08.054
ER  - 

@article{
author = "Manojlović, Dragica and Dramićanin, Miroslav and Milošević, Miloš and Zeković, Ivana Lj. and Cvijović-Alagić, Ivana and Mitrović, Nenad and Miletić, Vesna",
year = "2016",
abstract = "This study investigated the degree of conversion, depth of cure, Vickers hardness, flexural strength, flexural modulus and volumetric shrinkage of experimental composite containing a low shrinkage monomer FIT-852 (FIT; Esstech Inc.) and photoinitiator 2,4,6-trimethylbenzoyldiphenylphosphine oxide (TPO; Sigma Aldrich) compared to conventional composite containing Bisphenol A-glycidyl methacrylate (BisGMA) and camphorquinone-amine photoinitiator system. The degree of conversion was generally higher in FIT-based composites (45-64% range) than in BisGMA-based composites (34-58% range). Vickers hardness, flexural strength and modulus were higher in BisGMA-based composites. A polywave light-curing unit was generally more efficient in terms of conversion and hardness of experimental composites than a monowave unit. FIT-based composite containing TPO showed the depth of cure below 2 mm irrespective of the curing light. The depth of cure of FIT-based composite containing CQ and BisGMA-based composites with either photoinitiator was in the range of 2.8-3.0 mm. Volumetric shrinkage of FIT-based composite (0.9-5.7% range) was lower than that of BisGMA-based composite (2.2-12% range). FIT may be used as a shrinkage reducing monomer compatible with the conventional CQ-amine system as well as the alternative TPO photoinitiator. However, the depth of cure of FIT_TPO composite requires boosting to achieve clinically recommended thickness of 2 mm. (C) 2015 Elsevier B.V. All rights reserved.",
journal = "Materials Science and Engineering. C: Materials for Biological Applications",
title = "Effects of a low-Shrinkage methacrylate monomer and monoacylphosphine oxide photoinitiator on curing efficiency and mechanical properties of experimental resin-based composites",
volume = "58",
pages = "487-494",
doi = "10.1016/j.msec.2015.08.054"
}

Manojlović, D., Dramićanin, M., Milošević, M., Zeković, I. Lj., Cvijović-Alagić, I., Mitrović, N.,& Miletić, V.. (2016). Effects of a low-Shrinkage methacrylate monomer and monoacylphosphine oxide photoinitiator on curing efficiency and mechanical properties of experimental resin-based composites. in Materials Science and Engineering. C: Materials for Biological Applications, 58, 487-494.
https://doi.org/10.1016/j.msec.2015.08.054

Manojlović D, Dramićanin M, Milošević M, Zeković IL, Cvijović-Alagić I, Mitrović N, Miletić V. Effects of a low-Shrinkage methacrylate monomer and monoacylphosphine oxide photoinitiator on curing efficiency and mechanical properties of experimental resin-based composites. in Materials Science and Engineering. C: Materials for Biological Applications. 2016;58:487-494.
doi:10.1016/j.msec.2015.08.054 .

Manojlović, Dragica, Dramićanin, Miroslav, Milošević, Miloš, Zeković, Ivana Lj., Cvijović-Alagić, Ivana, Mitrović, Nenad, Miletić, Vesna, "Effects of a low-Shrinkage methacrylate monomer and monoacylphosphine oxide photoinitiator on curing efficiency and mechanical properties of experimental resin-based composites" in Materials Science and Engineering. C: Materials for Biological Applications, 58 (2016):487-494,
https://doi.org/10.1016/j.msec.2015.08.054 . .

TY  - JOUR
AU  - Miletić, Vesna
AU  - Perić, Dejan
AU  - Milošević, Miloš
AU  - Manojlović, Dragica
AU  - Mitrović, Nenad
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1335
AB  - Objective. To compare strain and displacement of sculptable bulk-fill, low-shrinkage and conventional composites as well as dye penetration along the dentin-restoration interface. Methods. Modified Class II cavities (N= 5/group) were filled with sculptable bulk-fill (Filtek Bulk Fill Posterior, 3M ESPE; Tetric EvoCeram Bulk Fill, Ivoclar Vivadent; fiber-reinforced EverX Posterior, GC; giomer Beautifil Bulk, Schofu), low-shrinkage (Kalore, GC), nanohybrid (Tetric EvoCeram, Ivoclar Vivadent) or microhybrid (Filtek Z250, 3M ESPE) composites. Strain and displacement were determined using the 3D digital image correlation method based on two cameras with 1 mu m displacement sensitivity and 1600 x 1200 pixel resolution (Aramis, GOM). Microleakage along dentin axial and gingival cavity walls was measured under a stereomicroscope using a different set of teeth (N = 8/group). Data were analyzed using analyses of variance with Tukeys post-test, Pearson correlation and paired t-test (alpha = 0.05). Results. Strain of TEC Bulk, Filtek Bulk, Beautifil Bulk and Kalore was in the range of 1-1.5%. EverX and control composites showed 1.5-2% strain. Axial displacements were between 5 mu m and 30 mu m The least strain was identified at 2 mm below the occlusal surface in 4-mm but not in 2-mm layered composites. Greater microleakage occurred along the gingival than axial wall (p LT 0.05). No correlation was found between strain/displacements and microleakage axially (r(2) = 0.082, p = 0.821; r(2) =-0.2, p = 0.605, respectively) or gingivally (r(2) =-0.126, p = 0.729, r(2) =-0.278, p = 0.469, respectively). Significance. Strain i.e. volumetric shrinkage of sculptable bulk-fill and low-shrinkage composites was comparable to control composites but strain distribution across restoration depth differed. Marginal integrity was more compromised along the gingival than axial dentin wall. (C) 2016 The Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.
T2  - Dental Materials
T1  - Local deformation fields and marginal integrity of sculptable bulk-fill, low-shrinkage and conventional composites
VL  - 32
IS  - 11
SP  - 1441
EP  - 1451
DO  - 10.1016/j.dental.2016.09.011
ER  - 

@article{
author = "Miletić, Vesna and Perić, Dejan and Milošević, Miloš and Manojlović, Dragica and Mitrović, Nenad",
year = "2016",
abstract = "Objective. To compare strain and displacement of sculptable bulk-fill, low-shrinkage and conventional composites as well as dye penetration along the dentin-restoration interface. Methods. Modified Class II cavities (N= 5/group) were filled with sculptable bulk-fill (Filtek Bulk Fill Posterior, 3M ESPE; Tetric EvoCeram Bulk Fill, Ivoclar Vivadent; fiber-reinforced EverX Posterior, GC; giomer Beautifil Bulk, Schofu), low-shrinkage (Kalore, GC), nanohybrid (Tetric EvoCeram, Ivoclar Vivadent) or microhybrid (Filtek Z250, 3M ESPE) composites. Strain and displacement were determined using the 3D digital image correlation method based on two cameras with 1 mu m displacement sensitivity and 1600 x 1200 pixel resolution (Aramis, GOM). Microleakage along dentin axial and gingival cavity walls was measured under a stereomicroscope using a different set of teeth (N = 8/group). Data were analyzed using analyses of variance with Tukeys post-test, Pearson correlation and paired t-test (alpha = 0.05). Results. Strain of TEC Bulk, Filtek Bulk, Beautifil Bulk and Kalore was in the range of 1-1.5%. EverX and control composites showed 1.5-2% strain. Axial displacements were between 5 mu m and 30 mu m The least strain was identified at 2 mm below the occlusal surface in 4-mm but not in 2-mm layered composites. Greater microleakage occurred along the gingival than axial wall (p LT 0.05). No correlation was found between strain/displacements and microleakage axially (r(2) = 0.082, p = 0.821; r(2) =-0.2, p = 0.605, respectively) or gingivally (r(2) =-0.126, p = 0.729, r(2) =-0.278, p = 0.469, respectively). Significance. Strain i.e. volumetric shrinkage of sculptable bulk-fill and low-shrinkage composites was comparable to control composites but strain distribution across restoration depth differed. Marginal integrity was more compromised along the gingival than axial dentin wall. (C) 2016 The Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.",
journal = "Dental Materials",
title = "Local deformation fields and marginal integrity of sculptable bulk-fill, low-shrinkage and conventional composites",
volume = "32",
number = "11",
pages = "1441-1451",
doi = "10.1016/j.dental.2016.09.011"
}

Miletić, V., Perić, D., Milošević, M., Manojlović, D.,& Mitrović, N.. (2016). Local deformation fields and marginal integrity of sculptable bulk-fill, low-shrinkage and conventional composites. in Dental Materials, 32(11), 1441-1451.
https://doi.org/10.1016/j.dental.2016.09.011

Miletić V, Perić D, Milošević M, Manojlović D, Mitrović N. Local deformation fields and marginal integrity of sculptable bulk-fill, low-shrinkage and conventional composites. in Dental Materials. 2016;32(11):1441-1451.
doi:10.1016/j.dental.2016.09.011 .

Miletić, Vesna, Perić, Dejan, Milošević, Miloš, Manojlović, Dragica, Mitrović, Nenad, "Local deformation fields and marginal integrity of sculptable bulk-fill, low-shrinkage and conventional composites" in Dental Materials, 32, no. 11 (2016):1441-1451,
https://doi.org/10.1016/j.dental.2016.09.011 . .

TY  - JOUR
AU  - Manojlović, Dragica
AU  - Dramićanin, Miroslav
AU  - Ležaja, Maja
AU  - Pongprueksa, Pong
AU  - Van Meerbeek, Bart
AU  - Miletić, Vesna
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/953
AB  - Objective. To study the effect of a low-shrinkage methacrylate monomer and monoacylphosphine oxide photoinitiator on color, translucency, and color stability of model resin-based composites (RBCs). Methods. Four micro-hybrid RBCs were prepared containing barium-glass fillers in bisphenol A-glycidyl-methacrylate (BisGMA) and triethyleneglycol-dimethacrylate (TEGDMA) or urethane-based low-shrinkage monomer FIT-852 (FIT; Esstech Inc.) and TEGDMA matrix. Camphorquinone (CQ)/amine or Lucirin TPO were used as photoinitiators. Commercial low-shrinkage RBCs (Charisma Diamond, Heraeus Kulzer and NDurance, Septodont) and conventional RBCs (Tetric EvoCeram, Ivoclar Vivadent and Filtek Z250, 3M ESPE) were used as controls. Color and translucency were measured using Thermo Scientific Evolution (Thermo Fisher Scientific) and SpectroShade (TM) Micro (MHT Optic Research) spectrophotometers. Color stability was evaluated after immersion in black tea (pure, with milk or lemon) and distilled water. Data were analyzed using analyses of variance with Tukeys post-test (alpha = 0.05). Results. Photoinitiators had no significant effect on baseline color. Initially whiter FIT-based RBCs showed greater staining in all staining solutions than BisGMA-based RBCs. TPO-containing RBCs showed better color stability than CQ-containing RBCs irrespective of the base monomer. Tea and tea with lemon induced greatest color changes. Adding milk to tea significantly reduced material staining. Significance. Urethane-based low-shrinkage monomer FIT and conventional BisGMA affected color, translucency and color stability of their respective RBCs. Despite being used in posterior teeth, low-shrinkage RBCs are expected to have favorable optical and esthetic properties. Manufacturers are urged to provide information on optical properties of monomers and monomer mixtures in their low-shrinkage RBCs to allow understanding of interaction with fillers and photoinitiators. (C) 2015 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.
PB  - Elsevier
T2  - Dental Materials
T1  - Effect of resin and photoinitiator on color, translucency and color stability of conventional and low-shrinkage model composites
VL  - 32
IS  - 2
SP  - 183
EP  - 191
DO  - 10.1016/j.dental.2015.11.027
ER  - 

@article{
author = "Manojlović, Dragica and Dramićanin, Miroslav and Ležaja, Maja and Pongprueksa, Pong and Van Meerbeek, Bart and Miletić, Vesna",
year = "2016",
abstract = "Objective. To study the effect of a low-shrinkage methacrylate monomer and monoacylphosphine oxide photoinitiator on color, translucency, and color stability of model resin-based composites (RBCs). Methods. Four micro-hybrid RBCs were prepared containing barium-glass fillers in bisphenol A-glycidyl-methacrylate (BisGMA) and triethyleneglycol-dimethacrylate (TEGDMA) or urethane-based low-shrinkage monomer FIT-852 (FIT; Esstech Inc.) and TEGDMA matrix. Camphorquinone (CQ)/amine or Lucirin TPO were used as photoinitiators. Commercial low-shrinkage RBCs (Charisma Diamond, Heraeus Kulzer and NDurance, Septodont) and conventional RBCs (Tetric EvoCeram, Ivoclar Vivadent and Filtek Z250, 3M ESPE) were used as controls. Color and translucency were measured using Thermo Scientific Evolution (Thermo Fisher Scientific) and SpectroShade (TM) Micro (MHT Optic Research) spectrophotometers. Color stability was evaluated after immersion in black tea (pure, with milk or lemon) and distilled water. Data were analyzed using analyses of variance with Tukeys post-test (alpha = 0.05). Results. Photoinitiators had no significant effect on baseline color. Initially whiter FIT-based RBCs showed greater staining in all staining solutions than BisGMA-based RBCs. TPO-containing RBCs showed better color stability than CQ-containing RBCs irrespective of the base monomer. Tea and tea with lemon induced greatest color changes. Adding milk to tea significantly reduced material staining. Significance. Urethane-based low-shrinkage monomer FIT and conventional BisGMA affected color, translucency and color stability of their respective RBCs. Despite being used in posterior teeth, low-shrinkage RBCs are expected to have favorable optical and esthetic properties. Manufacturers are urged to provide information on optical properties of monomers and monomer mixtures in their low-shrinkage RBCs to allow understanding of interaction with fillers and photoinitiators. (C) 2015 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.",
publisher = "Elsevier",
journal = "Dental Materials",
title = "Effect of resin and photoinitiator on color, translucency and color stability of conventional and low-shrinkage model composites",
volume = "32",
number = "2",
pages = "183-191",
doi = "10.1016/j.dental.2015.11.027"
}

Manojlović, D., Dramićanin, M., Ležaja, M., Pongprueksa, P., Van Meerbeek, B.,& Miletić, V.. (2016). Effect of resin and photoinitiator on color, translucency and color stability of conventional and low-shrinkage model composites. in Dental Materials
Elsevier., 32(2), 183-191.
https://doi.org/10.1016/j.dental.2015.11.027

Manojlović D, Dramićanin M, Ležaja M, Pongprueksa P, Van Meerbeek B, Miletić V. Effect of resin and photoinitiator on color, translucency and color stability of conventional and low-shrinkage model composites. in Dental Materials. 2016;32(2):183-191.
doi:10.1016/j.dental.2015.11.027 .

Manojlović, Dragica, Dramićanin, Miroslav, Ležaja, Maja, Pongprueksa, Pong, Van Meerbeek, Bart, Miletić, Vesna, "Effect of resin and photoinitiator on color, translucency and color stability of conventional and low-shrinkage model composites" in Dental Materials, 32, no. 2 (2016):183-191,
https://doi.org/10.1016/j.dental.2015.11.027 . .

TY  - JOUR
AU  - Petrović, V.
AU  - Opacic-Galic, V.
AU  - Zivkovic, S.
AU  - Nikolić, Biljana
AU  - Danilovic, V.
AU  - Miletic, V.
AU  - Jokanović, Vukoman R.
AU  - Mitić-Ćulafić, Dragana
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/722
AB  - AimTo evaluate in vitro cytotoxicity and in vivo inflammatory response to new nanostructural materials based on active calcium silicate systems (CS) and hydroxyapatite (HA-CS). MethodologyCytotoxicity of eluates of new nanostructural noncommercial materials CS and HA-CS, and MTA (White MTA, Angelus((R)) Solucoes Odontologicas, Londrina, Brazil) as a control, were tested using the MTT assay on MRC-5 cells. Eluates of set materials were tested in 100% and 50% concentrations, 24h, 7days and 21days post-elution. The pH values were determined for undiluted eluates of set materials. Polyethylene tubes containing the test materials (CS, HA-CS, MTA) were implanted in subcutaneous tissue of Wistar rats. Histopathological examinations were conducted at 7, 15, 30 and 60days after the implantation. Data were statistically analyzed using three-way and one-way anova Tukeys post hoc test as well as Kruskall-Wallis test with Dunns post hoc test at =0.05. ResultsAll materials significantly reduced cell viability; especially when undiluted eluates were used (P LT 0.001). After 24h elution, cell viability was 101.8%, 49.5 +/- 4.2% and 61 +/- 7.4%, for MTA, and HA-CS, respectively. However, CS and HA-CS were significantly less toxic than the control material MTA (P LT 0.05). Cytotoxicity could be at least partially attributed to pH kinetics over time. Dilution of eluates of all tested materials resulted in better cell survival. Histopathological examination indicated similar inflammatory reaction, vascular congestion and connective tissue integrity associated with CS, HA-CS and MTA at each observation period (P GT 0.05). The only significant difference was found for capsule thickness, that is thicker capsule was associated with HA-CS compared to MTA at 60days (P=0.0039). HA-CS induced moderately thick capsules (median score 3, score range 2-3), whereas MTA resulted in thin capsule formation (median score 2, score range 1-3). ConclusionsEvaluation of cytotoxicity and inflammatory response indicated better biocompatibility of CS and HA-CS, in comparison with MTA (White MTA, Angelus((R)) Solucoes Odontologicas, Londrina, Brazil).
T2  - International Endodontic Journal
T1  - Biocompatibility of new nanostructural materials based on active silicate systems and hydroxyapatite: in vitro and in vivo study
VL  - 48
IS  - 10
SP  - 966
EP  - 975
DO  - 10.1111/iej.12391
ER  - 

@article{
author = "Petrović, V. and Opacic-Galic, V. and Zivkovic, S. and Nikolić, Biljana and Danilovic, V. and Miletic, V. and Jokanović, Vukoman R. and Mitić-Ćulafić, Dragana",
year = "2015",
abstract = "AimTo evaluate in vitro cytotoxicity and in vivo inflammatory response to new nanostructural materials based on active calcium silicate systems (CS) and hydroxyapatite (HA-CS). MethodologyCytotoxicity of eluates of new nanostructural noncommercial materials CS and HA-CS, and MTA (White MTA, Angelus((R)) Solucoes Odontologicas, Londrina, Brazil) as a control, were tested using the MTT assay on MRC-5 cells. Eluates of set materials were tested in 100% and 50% concentrations, 24h, 7days and 21days post-elution. The pH values were determined for undiluted eluates of set materials. Polyethylene tubes containing the test materials (CS, HA-CS, MTA) were implanted in subcutaneous tissue of Wistar rats. Histopathological examinations were conducted at 7, 15, 30 and 60days after the implantation. Data were statistically analyzed using three-way and one-way anova Tukeys post hoc test as well as Kruskall-Wallis test with Dunns post hoc test at =0.05. ResultsAll materials significantly reduced cell viability; especially when undiluted eluates were used (P LT 0.001). After 24h elution, cell viability was 101.8%, 49.5 +/- 4.2% and 61 +/- 7.4%, for MTA, and HA-CS, respectively. However, CS and HA-CS were significantly less toxic than the control material MTA (P LT 0.05). Cytotoxicity could be at least partially attributed to pH kinetics over time. Dilution of eluates of all tested materials resulted in better cell survival. Histopathological examination indicated similar inflammatory reaction, vascular congestion and connective tissue integrity associated with CS, HA-CS and MTA at each observation period (P GT 0.05). The only significant difference was found for capsule thickness, that is thicker capsule was associated with HA-CS compared to MTA at 60days (P=0.0039). HA-CS induced moderately thick capsules (median score 3, score range 2-3), whereas MTA resulted in thin capsule formation (median score 2, score range 1-3). ConclusionsEvaluation of cytotoxicity and inflammatory response indicated better biocompatibility of CS and HA-CS, in comparison with MTA (White MTA, Angelus((R)) Solucoes Odontologicas, Londrina, Brazil).",
journal = "International Endodontic Journal",
title = "Biocompatibility of new nanostructural materials based on active silicate systems and hydroxyapatite: in vitro and in vivo study",
volume = "48",
number = "10",
pages = "966-975",
doi = "10.1111/iej.12391"
}

Petrović, V., Opacic-Galic, V., Zivkovic, S., Nikolić, B., Danilovic, V., Miletic, V., Jokanović, V. R.,& Mitić-Ćulafić, D.. (2015). Biocompatibility of new nanostructural materials based on active silicate systems and hydroxyapatite: in vitro and in vivo study. in International Endodontic Journal, 48(10), 966-975.
https://doi.org/10.1111/iej.12391

Petrović V, Opacic-Galic V, Zivkovic S, Nikolić B, Danilovic V, Miletic V, Jokanović VR, Mitić-Ćulafić D. Biocompatibility of new nanostructural materials based on active silicate systems and hydroxyapatite: in vitro and in vivo study. in International Endodontic Journal. 2015;48(10):966-975.
doi:10.1111/iej.12391 .

Petrović, V., Opacic-Galic, V., Zivkovic, S., Nikolić, Biljana, Danilovic, V., Miletic, V., Jokanović, Vukoman R., Mitić-Ćulafić, Dragana, "Biocompatibility of new nanostructural materials based on active silicate systems and hydroxyapatite: in vitro and in vivo study" in International Endodontic Journal, 48, no. 10 (2015):966-975,
https://doi.org/10.1111/iej.12391 . .

TY  - JOUR
AU  - Manojlović, Dragan D.
AU  - Lenhardt, Lea I.
AU  - Milićević, Bojana R.
AU  - Antonov, Milica
AU  - Miletic, V.
AU  - Dramićanin, Miroslav
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/763
AB  - Colour changes in Gradia Direct (TM) composite after immersion in tea, coffee, red wine, Coca-Cola, Colgate mouthwash, and distilled water were evaluated using principal component analysis (PCA) and the CIELAB colour coordinates. The reflection spectra of the composites were used as input data for the PCA. The output data (scores and loadings) provided information about the magnitude and origin of the surface reflection changes after exposure to the staining solutions. The reflection spectra of the stained samples generally exhibited lower reflection in the blue spectral range, which was manifested in the lower content of the blue shade for the samples. Both analyses demonstrated the high staining abilities of tea, coffee, and red wine, which produced total colour changes of 4.31, 6.61, and 6.22, respectively, according to the CIELAB analysis. PCA revealed subtle changes in the reflection spectra of composites immersed in Coca-Cola, demonstrating Coca-Colas ability to stain the composite to a small degree.
T2  - Scientific Reports
T1  - Evaluation of Staining-Dependent Colour Changes in Resin Composites Using Principal Component Analysis
VL  - 5
DO  - 10.1038/srep14638
ER  - 

@article{
author = "Manojlović, Dragan D. and Lenhardt, Lea I. and Milićević, Bojana R. and Antonov, Milica and Miletic, V. and Dramićanin, Miroslav",
year = "2015",
abstract = "Colour changes in Gradia Direct (TM) composite after immersion in tea, coffee, red wine, Coca-Cola, Colgate mouthwash, and distilled water were evaluated using principal component analysis (PCA) and the CIELAB colour coordinates. The reflection spectra of the composites were used as input data for the PCA. The output data (scores and loadings) provided information about the magnitude and origin of the surface reflection changes after exposure to the staining solutions. The reflection spectra of the stained samples generally exhibited lower reflection in the blue spectral range, which was manifested in the lower content of the blue shade for the samples. Both analyses demonstrated the high staining abilities of tea, coffee, and red wine, which produced total colour changes of 4.31, 6.61, and 6.22, respectively, according to the CIELAB analysis. PCA revealed subtle changes in the reflection spectra of composites immersed in Coca-Cola, demonstrating Coca-Colas ability to stain the composite to a small degree.",
journal = "Scientific Reports",
title = "Evaluation of Staining-Dependent Colour Changes in Resin Composites Using Principal Component Analysis",
volume = "5",
doi = "10.1038/srep14638"
}

Manojlović, D. D., Lenhardt, L. I., Milićević, B. R., Antonov, M., Miletic, V.,& Dramićanin, M.. (2015). Evaluation of Staining-Dependent Colour Changes in Resin Composites Using Principal Component Analysis. in Scientific Reports, 5.
https://doi.org/10.1038/srep14638

Manojlović DD, Lenhardt LI, Milićević BR, Antonov M, Miletic V, Dramićanin M. Evaluation of Staining-Dependent Colour Changes in Resin Composites Using Principal Component Analysis. in Scientific Reports. 2015;5.
doi:10.1038/srep14638 .

Manojlović, Dragan D., Lenhardt, Lea I., Milićević, Bojana R., Antonov, Milica, Miletic, V., Dramićanin, Miroslav, "Evaluation of Staining-Dependent Colour Changes in Resin Composites Using Principal Component Analysis" in Scientific Reports, 5 (2015),
https://doi.org/10.1038/srep14638 . .

TY  - JOUR
AU  - Ležaja, Maja
AU  - Veljović, Đorđe N.
AU  - Jokić, Bojan M.
AU  - Cvijović-Alagić, Ivana
AU  - Zrilic, Milorad M.
AU  - Miletić, Vesna
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5797
AB  - This study investigated the effect of shape, size, and surface modification of hydroxyapatite (HAP) fillers on the degree of conversion (DC) and mechanical properties of a model BisGMA/TEGDMA composite initially and after 4 weeks of storage. Ten percent of conventional glass fillers were replaced by HAP spheres (Sph), silicon-doped spheres (Sph(Si)), whiskers (Wh), silicon-doped whiskers (Wh(Si)), and nanosized HAP particles (Nano). Spheres were specifically structured agglomerates consisting of a central void and radially orientated primary particles, whereas whiskers were compact monocrystals. DC, Vickers hardness (HV), flexural strength (Fs), flexural modulus (Ef), compressive strength (Cs), and compressive modulus (Ec) were tested. There were no significant differences in the DC between all tested groups. HV decreased by 5.4-17% with the addition of HAP, while Fs increased by 13.9-29% except in Nano group (decrease by 13%). After storage, Sph and Sph(Si) groups showed similar HV, Ef, Cs and Ec and higher Fs than the control. The fracture mode of HAP spheres was through the central void whereas whiskers showed longitudinal delamination, transverse, and mixed fractures. HAP spheres with or without silicon- doping have a potential to be part of the filler content of dental composites. (c) 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 101B: 1469-1476, 2013.
T2  - Journal of Biomedical Materials Research. Part B: Applied Biomaterials
T1  - Effect of hydroxyapatite spheres, whiskers, and nanoparticles on mechanical properties of a model BisGMA/TEGDMA composite initially and after storage
VL  - 101
IS  - 8
SP  - 1469
EP  - 1476
DO  - 10.1002/jbm.b.32967
ER  - 

@article{
author = "Ležaja, Maja and Veljović, Đorđe N. and Jokić, Bojan M. and Cvijović-Alagić, Ivana and Zrilic, Milorad M. and Miletić, Vesna",
year = "2013",
abstract = "This study investigated the effect of shape, size, and surface modification of hydroxyapatite (HAP) fillers on the degree of conversion (DC) and mechanical properties of a model BisGMA/TEGDMA composite initially and after 4 weeks of storage. Ten percent of conventional glass fillers were replaced by HAP spheres (Sph), silicon-doped spheres (Sph(Si)), whiskers (Wh), silicon-doped whiskers (Wh(Si)), and nanosized HAP particles (Nano). Spheres were specifically structured agglomerates consisting of a central void and radially orientated primary particles, whereas whiskers were compact monocrystals. DC, Vickers hardness (HV), flexural strength (Fs), flexural modulus (Ef), compressive strength (Cs), and compressive modulus (Ec) were tested. There were no significant differences in the DC between all tested groups. HV decreased by 5.4-17% with the addition of HAP, while Fs increased by 13.9-29% except in Nano group (decrease by 13%). After storage, Sph and Sph(Si) groups showed similar HV, Ef, Cs and Ec and higher Fs than the control. The fracture mode of HAP spheres was through the central void whereas whiskers showed longitudinal delamination, transverse, and mixed fractures. HAP spheres with or without silicon- doping have a potential to be part of the filler content of dental composites. (c) 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 101B: 1469-1476, 2013.",
journal = "Journal of Biomedical Materials Research. Part B: Applied Biomaterials",
title = "Effect of hydroxyapatite spheres, whiskers, and nanoparticles on mechanical properties of a model BisGMA/TEGDMA composite initially and after storage",
volume = "101",
number = "8",
pages = "1469-1476",
doi = "10.1002/jbm.b.32967"
}

Ležaja, M., Veljović, Đ. N., Jokić, B. M., Cvijović-Alagić, I., Zrilic, M. M.,& Miletić, V.. (2013). Effect of hydroxyapatite spheres, whiskers, and nanoparticles on mechanical properties of a model BisGMA/TEGDMA composite initially and after storage. in Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 101(8), 1469-1476.
https://doi.org/10.1002/jbm.b.32967

Ležaja M, Veljović ĐN, Jokić BM, Cvijović-Alagić I, Zrilic MM, Miletić V. Effect of hydroxyapatite spheres, whiskers, and nanoparticles on mechanical properties of a model BisGMA/TEGDMA composite initially and after storage. in Journal of Biomedical Materials Research. Part B: Applied Biomaterials. 2013;101(8):1469-1476.
doi:10.1002/jbm.b.32967 .

Ležaja, Maja, Veljović, Đorđe N., Jokić, Bojan M., Cvijović-Alagić, Ivana, Zrilic, Milorad M., Miletić, Vesna, "Effect of hydroxyapatite spheres, whiskers, and nanoparticles on mechanical properties of a model BisGMA/TEGDMA composite initially and after storage" in Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 101, no. 8 (2013):1469-1476,
https://doi.org/10.1002/jbm.b.32967 . .