TY  - JOUR
AU  - Karageorgou, Maria-Argyro
AU  - Apostolopoulou, Adamantia
AU  - Tomazinaki, Mina-Ermioni
AU  - Stanković, Dragana
AU  - Stiliaris, Efstathios
AU  - Bouziotis, Penelope
AU  - Stamopoulos, Dimosthenis
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12719
AB  - The radiolabeled iron oxide nanoparticles constitute an attractive choice to be used as dual-modality contrast agents (DMCAs) in nuclear medical diagnosis, due to their ability to combine the benefits of two imaging modalities, for instance single photon emission computed tomography (SPECT) with magnetic resonance imaging (MRI). Before the use of any DMCA, the investigation of its plasma extra- and on/intra cellular distribution in peripheral human blood is of paramount importance. Here, we focus on the in vitro investigation of the distribution of 99mTc-DPD-Fe3O4 DMCA in donated peripheral human blood (the ligand 2-3-dicarboxypropane-1-1-diphosphonic-acid is denoted as DPD). Initially, we described the experimental methods we performed for the radiosynthesis of the 99mTc-DPD-Fe3O4, the preparation of whole blood and blood plasma samples, and their incubation conditions with 99mTc-DPD-Fe3O4. More importantly, we employed a gamma-camera apparatus for the direct imaging of the 99mTc-DPD-Fe3O4-loaded whole blood and blood plasma samples when subjected to specialized centrifugation protocols. The direct comparison of the gamma-camera data obtained at the exact same samples before and after their centrifugation enabled us to clearly identify the distribution of the 99mTc-DPD-Fe3O4 in the two components, plasma and cells, of peripheral human blood.
T2  - Materials
T1  - Gamma-Camera Direct Imaging of the Plasma and On/Intra Cellular Distribution of the 99mTc-DPD-Fe3O4 Dual-Modality Contrast Agent in Peripheral Human Blood
VL  - 17
IS  - 2
SP  - 335
DO  - 10.3390/ma17020335
ER  - 

@article{
author = "Karageorgou, Maria-Argyro and Apostolopoulou, Adamantia and Tomazinaki, Mina-Ermioni and Stanković, Dragana and Stiliaris, Efstathios and Bouziotis, Penelope and Stamopoulos, Dimosthenis",
year = "2024",
abstract = "The radiolabeled iron oxide nanoparticles constitute an attractive choice to be used as dual-modality contrast agents (DMCAs) in nuclear medical diagnosis, due to their ability to combine the benefits of two imaging modalities, for instance single photon emission computed tomography (SPECT) with magnetic resonance imaging (MRI). Before the use of any DMCA, the investigation of its plasma extra- and on/intra cellular distribution in peripheral human blood is of paramount importance. Here, we focus on the in vitro investigation of the distribution of 99mTc-DPD-Fe3O4 DMCA in donated peripheral human blood (the ligand 2-3-dicarboxypropane-1-1-diphosphonic-acid is denoted as DPD). Initially, we described the experimental methods we performed for the radiosynthesis of the 99mTc-DPD-Fe3O4, the preparation of whole blood and blood plasma samples, and their incubation conditions with 99mTc-DPD-Fe3O4. More importantly, we employed a gamma-camera apparatus for the direct imaging of the 99mTc-DPD-Fe3O4-loaded whole blood and blood plasma samples when subjected to specialized centrifugation protocols. The direct comparison of the gamma-camera data obtained at the exact same samples before and after their centrifugation enabled us to clearly identify the distribution of the 99mTc-DPD-Fe3O4 in the two components, plasma and cells, of peripheral human blood.",
journal = "Materials",
title = "Gamma-Camera Direct Imaging of the Plasma and On/Intra Cellular Distribution of the 99mTc-DPD-Fe3O4 Dual-Modality Contrast Agent in Peripheral Human Blood",
volume = "17",
number = "2",
pages = "335",
doi = "10.3390/ma17020335"
}

Karageorgou, M., Apostolopoulou, A., Tomazinaki, M., Stanković, D., Stiliaris, E., Bouziotis, P.,& Stamopoulos, D.. (2024). Gamma-Camera Direct Imaging of the Plasma and On/Intra Cellular Distribution of the 99mTc-DPD-Fe3O4 Dual-Modality Contrast Agent in Peripheral Human Blood. in Materials, 17(2), 335.
https://doi.org/10.3390/ma17020335

Karageorgou M, Apostolopoulou A, Tomazinaki M, Stanković D, Stiliaris E, Bouziotis P, Stamopoulos D. Gamma-Camera Direct Imaging of the Plasma and On/Intra Cellular Distribution of the 99mTc-DPD-Fe3O4 Dual-Modality Contrast Agent in Peripheral Human Blood. in Materials. 2024;17(2):335.
doi:10.3390/ma17020335 .

Karageorgou, Maria-Argyro, Apostolopoulou, Adamantia, Tomazinaki, Mina-Ermioni, Stanković, Dragana, Stiliaris, Efstathios, Bouziotis, Penelope, Stamopoulos, Dimosthenis, "Gamma-Camera Direct Imaging of the Plasma and On/Intra Cellular Distribution of the 99mTc-DPD-Fe3O4 Dual-Modality Contrast Agent in Peripheral Human Blood" in Materials, 17, no. 2 (2024):335,
https://doi.org/10.3390/ma17020335 . .