TY  - JOUR
AU  - Čakar, Uroš
AU  - Čolović, Mirjana B.
AU  - Milenković, Danijela
AU  - Medić, Branislava
AU  - Krstić, Danijela Z.
AU  - Petrović, Aleksandar
AU  - Ðoređvić, Brižita
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9889
AB  - This study aimed to evaluate, in vitro, the antioxidative potential of fruit wines produced from berry fruits (i.e., black chokeberry, blueberry, blackberry, and raspberry), cherry, and apple by different technological processes. For this purpose, the activities of antioxidant enzymes (catalase, glutathione peroxidase (GPx), and superoxide dismutase (SOD)) and malondialdehyde (MDA) content as a marker of membrane damage were determined in wine-treated synaptosomes with hydrogen peroxide-induced oxidative stress. All studied wines induced increased antioxidant enzyme activities and decreased MDA levels compared to hydrogen peroxide-treated synaptosomes (i.e., control). The highest SOD activity was observed in synaptosomes treated with blackberry wine (6.81 U/mg), whereas blueberry wine induced the highest catalase and glutathione peroxidase activities (0.058 U/mg and 0.017 U/mg, respectively). Black chokeberry proved to be the best in lipid peroxidation protection with the lowest MDA value (1.42 nmol/mg). Finally, principal component analysis and hierarchical cluster analysis additionally highlighted a higher antioxidant capacity of wines produced from dark-skinned fruits (i.e., blackberry, black chokeberry, and blueberry). The results suggest protective effects of the fruit wines against oxidative damage, and, accordingly, their promising application as functional food.
T2  - Agronomy
T1  - Protective effects of fruit wines against hydrogen peroxide—induced oxidative stress in rat synaptosomes
VL  - 11
IS  - 7
SP  - 1414
DO  - 10.3390/agronomy11071414
ER  - 

@article{
author = "Čakar, Uroš and Čolović, Mirjana B. and Milenković, Danijela and Medić, Branislava and Krstić, Danijela Z. and Petrović, Aleksandar and Ðoređvić, Brižita",
year = "2021",
abstract = "This study aimed to evaluate, in vitro, the antioxidative potential of fruit wines produced from berry fruits (i.e., black chokeberry, blueberry, blackberry, and raspberry), cherry, and apple by different technological processes. For this purpose, the activities of antioxidant enzymes (catalase, glutathione peroxidase (GPx), and superoxide dismutase (SOD)) and malondialdehyde (MDA) content as a marker of membrane damage were determined in wine-treated synaptosomes with hydrogen peroxide-induced oxidative stress. All studied wines induced increased antioxidant enzyme activities and decreased MDA levels compared to hydrogen peroxide-treated synaptosomes (i.e., control). The highest SOD activity was observed in synaptosomes treated with blackberry wine (6.81 U/mg), whereas blueberry wine induced the highest catalase and glutathione peroxidase activities (0.058 U/mg and 0.017 U/mg, respectively). Black chokeberry proved to be the best in lipid peroxidation protection with the lowest MDA value (1.42 nmol/mg). Finally, principal component analysis and hierarchical cluster analysis additionally highlighted a higher antioxidant capacity of wines produced from dark-skinned fruits (i.e., blackberry, black chokeberry, and blueberry). The results suggest protective effects of the fruit wines against oxidative damage, and, accordingly, their promising application as functional food.",
journal = "Agronomy",
title = "Protective effects of fruit wines against hydrogen peroxide—induced oxidative stress in rat synaptosomes",
volume = "11",
number = "7",
pages = "1414",
doi = "10.3390/agronomy11071414"
}

Čakar, U., Čolović, M. B., Milenković, D., Medić, B., Krstić, D. Z., Petrović, A.,& Ðoređvić, B.. (2021). Protective effects of fruit wines against hydrogen peroxide—induced oxidative stress in rat synaptosomes. in Agronomy, 11(7), 1414.
https://doi.org/10.3390/agronomy11071414

Čakar U, Čolović MB, Milenković D, Medić B, Krstić DZ, Petrović A, Ðoređvić B. Protective effects of fruit wines against hydrogen peroxide—induced oxidative stress in rat synaptosomes. in Agronomy. 2021;11(7):1414.
doi:10.3390/agronomy11071414 .

Čakar, Uroš, Čolović, Mirjana B., Milenković, Danijela, Medić, Branislava, Krstić, Danijela Z., Petrović, Aleksandar, Ðoređvić, Brižita, "Protective effects of fruit wines against hydrogen peroxide—induced oxidative stress in rat synaptosomes" in Agronomy, 11, no. 7 (2021):1414,
https://doi.org/10.3390/agronomy11071414 . .

TY  - JOUR
AU  - Medić, Branislava
AU  - Stojanović, Marko
AU  - Stimec, Bojan V.
AU  - Divac, Nevena
AU  - Savić Vujović, Katarina
AU  - Stojanović, Radan
AU  - Čolović, Mirjana B.
AU  - Krstić, Danijela Z.
AU  - Prostran, Milica
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8838
AB  - Lithium is the smallest monovalent cation with many different biological effects. Although lithium is present in the pharmacotherapy of psychiatric illnesses for decades, its precise mechanism of action is still not clarified. Today lithium represents first-line therapy for bipolar disorders (because it possesses both antimanic and antidepressant properties) and the adjunctive treatment for major depression (due to its antisuicidal effects). Beside, lithium showed some protective effects in neurological diseases including acute neural injury, chronic degenerative conditions, Alzheimer's disease as well as in treating leucopenia, hepatitis and some renal diseases. Recent evidence suggested that lithium also possesses some anticancer properties due to its inhibition of Glycogen Synthase Kinase 3 beta (GSK3β) which is included in the regulation of a lot of important cellular processes such as: glycogen metabolism, inflammation, immunomodulation, apoptosis, tissue injury, regeneration etc. Although recent evidence suggested a potential utility of lithium in different conditions, its broader use in clinical practice still trails. The reason for this is a narrow therapeutic index of lithium, numerous toxic effects in various organ systems and some clinically relevant interactions with other drugs. Additionally, it is necessary to perform more preclinical as well as clinical studies in order to a precise therapeutic range of lithium, as well as its detailed mechanism of action. The aim of this review is to summarize the current knowledge concerning the pharmacological and toxicological effects of lithium. © 2020 Bentham Science Publishers.
T2  - Current Medicinal Chemistry
T1  - Lithium - Pharmacological and Toxicological Aspects: The Current State of the Art
VL  - 27
IS  - 3
SP  - 337
EP  - 351
DO  - 10.2174/0929867325666180904124733
ER  - 

@article{
author = "Medić, Branislava and Stojanović, Marko and Stimec, Bojan V. and Divac, Nevena and Savić Vujović, Katarina and Stojanović, Radan and Čolović, Mirjana B. and Krstić, Danijela Z. and Prostran, Milica",
year = "2020",
abstract = "Lithium is the smallest monovalent cation with many different biological effects. Although lithium is present in the pharmacotherapy of psychiatric illnesses for decades, its precise mechanism of action is still not clarified. Today lithium represents first-line therapy for bipolar disorders (because it possesses both antimanic and antidepressant properties) and the adjunctive treatment for major depression (due to its antisuicidal effects). Beside, lithium showed some protective effects in neurological diseases including acute neural injury, chronic degenerative conditions, Alzheimer's disease as well as in treating leucopenia, hepatitis and some renal diseases. Recent evidence suggested that lithium also possesses some anticancer properties due to its inhibition of Glycogen Synthase Kinase 3 beta (GSK3β) which is included in the regulation of a lot of important cellular processes such as: glycogen metabolism, inflammation, immunomodulation, apoptosis, tissue injury, regeneration etc. Although recent evidence suggested a potential utility of lithium in different conditions, its broader use in clinical practice still trails. The reason for this is a narrow therapeutic index of lithium, numerous toxic effects in various organ systems and some clinically relevant interactions with other drugs. Additionally, it is necessary to perform more preclinical as well as clinical studies in order to a precise therapeutic range of lithium, as well as its detailed mechanism of action. The aim of this review is to summarize the current knowledge concerning the pharmacological and toxicological effects of lithium. © 2020 Bentham Science Publishers.",
journal = "Current Medicinal Chemistry",
title = "Lithium - Pharmacological and Toxicological Aspects: The Current State of the Art",
volume = "27",
number = "3",
pages = "337-351",
doi = "10.2174/0929867325666180904124733"
}

Medić, B., Stojanović, M., Stimec, B. V., Divac, N., Savić Vujović, K., Stojanović, R., Čolović, M. B., Krstić, D. Z.,& Prostran, M.. (2020). Lithium - Pharmacological and Toxicological Aspects: The Current State of the Art. in Current Medicinal Chemistry, 27(3), 337-351.
https://doi.org/10.2174/0929867325666180904124733

Medić B, Stojanović M, Stimec BV, Divac N, Savić Vujović K, Stojanović R, Čolović MB, Krstić DZ, Prostran M. Lithium - Pharmacological and Toxicological Aspects: The Current State of the Art. in Current Medicinal Chemistry. 2020;27(3):337-351.
doi:10.2174/0929867325666180904124733 .

Medić, Branislava, Stojanović, Marko, Stimec, Bojan V., Divac, Nevena, Savić Vujović, Katarina, Stojanović, Radan, Čolović, Mirjana B., Krstić, Danijela Z., Prostran, Milica, "Lithium - Pharmacological and Toxicological Aspects: The Current State of the Art" in Current Medicinal Chemistry, 27, no. 3 (2020):337-351,
https://doi.org/10.2174/0929867325666180904124733 . .

TY  - CONF
AU  - Čakar, Uroš
AU  - Čolović, Mirjana
AU  - Vasić, Vesna M.
AU  - Medić, Branislava
AU  - Krstić, Danijela
AU  - Petrović, Aleksandar
AU  - Đorđević, Brižita
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13010
AB  - Natural active compounds from fruit possess significant antioxidant properties and beneficial effects on human health. Fruit wines also exhibit antioxidant properties resulted from many natural constituents important for health prevention.
PB  - Seoul, Republic of Korea : FIP-Interenational Pharmaceutical Federation
C3  - FIP 2017 : Pharmacy and Pharmaceutical Science World Congress : Book of abstracts
T1  - In vitro investigation of antioxodant properties of apple and black chokeberry wines
UR  - https://hdl.handle.net/21.15107/rcub_vinar_13010
ER  - 

@conference{
author = "Čakar, Uroš and Čolović, Mirjana and Vasić, Vesna M. and Medić, Branislava and Krstić, Danijela and Petrović, Aleksandar and Đorđević, Brižita",
year = "2017",
abstract = "Natural active compounds from fruit possess significant antioxidant properties and beneficial effects on human health. Fruit wines also exhibit antioxidant properties resulted from many natural constituents important for health prevention.",
publisher = "Seoul, Republic of Korea : FIP-Interenational Pharmaceutical Federation",
journal = "FIP 2017 : Pharmacy and Pharmaceutical Science World Congress : Book of abstracts",
title = "In vitro investigation of antioxodant properties of apple and black chokeberry wines",
url = "https://hdl.handle.net/21.15107/rcub_vinar_13010"
}

Čakar, U., Čolović, M., Vasić, V. M., Medić, B., Krstić, D., Petrović, A.,& Đorđević, B.. (2017). In vitro investigation of antioxodant properties of apple and black chokeberry wines. in FIP 2017 : Pharmacy and Pharmaceutical Science World Congress : Book of abstracts
Seoul, Republic of Korea : FIP-Interenational Pharmaceutical Federation..
https://hdl.handle.net/21.15107/rcub_vinar_13010

Čakar U, Čolović M, Vasić VM, Medić B, Krstić D, Petrović A, Đorđević B. In vitro investigation of antioxodant properties of apple and black chokeberry wines. in FIP 2017 : Pharmacy and Pharmaceutical Science World Congress : Book of abstracts. 2017;.
https://hdl.handle.net/21.15107/rcub_vinar_13010 .

Čakar, Uroš, Čolović, Mirjana, Vasić, Vesna M., Medić, Branislava, Krstić, Danijela, Petrović, Aleksandar, Đorđević, Brižita, "In vitro investigation of antioxodant properties of apple and black chokeberry wines" in FIP 2017 : Pharmacy and Pharmaceutical Science World Congress : Book of abstracts (2017),
https://hdl.handle.net/21.15107/rcub_vinar_13010 .