TY  - JOUR
AU  - Đurić, Tamara
AU  - Živković, Maja
AU  - Milosevic, Biljana
AU  - Anđelevski, Magdalena
AU  - Cvetković, Mirjana
AU  - Kostić, Mirjana M.
AU  - Stanković, Aleksandra
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5950
AB  - Congenital anomalies of the kidney and urinary tract (CAKUT) are a common cause of progressive chronic kidney disease that may lead to end-stage renal disease and renal replacement therapy in childhood. Altered expression or activity of matrix metalloproteinases (MMPs) have been found in CAKUT. The MMP-1, -3, and -8 polymorphisms studied here are located in the gene promoters and alter expression. Our aim was to investigate associations of MMP polymorphisms, solely and in haplotypes, with CAKUT in children. A case-control study with 101 pediatric patients and 281 controls was performed. The MMP-1 (-1607 1G/2G), -3 (5A/6A), and -8 (-799 C/T) genotypes were determined by PCR-restriction fragment length polymorphism. We found statistically significant associations of MMP-3 5A/6A polymorphism (p LT 0.0001) and 1G(-1607)-6A haplotype, with no preferences for MMP-8 -799C or T alleles, with CAKUT (OR = 2.93, 95 % CI 1.43-5.98, adjusted for gender, p = 0.003) and with obstructive uropathies in a subgroup of patients (OR = 4.57, 95 % CI 2.74-7.61, adjusted for gender, p LT 0.0001). MMP-3 genotypes and MMP-3 and -1 haplotypes encompassing either MMP-8 -799C or T alleles were associated with CAKUT and obstructive uropathies in pediatric patients. Still, functional and association studies are needed to elucidate evident roles of MMPs in CAKUT.
T2  - Pediatric Nephrology
T1  - MMP-1 and-3 haplotype is associated with congenital anomalies of the kidney and urinary tract
VL  - 29
IS  - 5
SP  - 879
EP  - 884
DO  - 10.1007/s00467-013-2699-x
ER  - 

@article{
author = "Đurić, Tamara and Živković, Maja and Milosevic, Biljana and Anđelevski, Magdalena and Cvetković, Mirjana and Kostić, Mirjana M. and Stanković, Aleksandra",
year = "2014",
abstract = "Congenital anomalies of the kidney and urinary tract (CAKUT) are a common cause of progressive chronic kidney disease that may lead to end-stage renal disease and renal replacement therapy in childhood. Altered expression or activity of matrix metalloproteinases (MMPs) have been found in CAKUT. The MMP-1, -3, and -8 polymorphisms studied here are located in the gene promoters and alter expression. Our aim was to investigate associations of MMP polymorphisms, solely and in haplotypes, with CAKUT in children. A case-control study with 101 pediatric patients and 281 controls was performed. The MMP-1 (-1607 1G/2G), -3 (5A/6A), and -8 (-799 C/T) genotypes were determined by PCR-restriction fragment length polymorphism. We found statistically significant associations of MMP-3 5A/6A polymorphism (p LT 0.0001) and 1G(-1607)-6A haplotype, with no preferences for MMP-8 -799C or T alleles, with CAKUT (OR = 2.93, 95 % CI 1.43-5.98, adjusted for gender, p = 0.003) and with obstructive uropathies in a subgroup of patients (OR = 4.57, 95 % CI 2.74-7.61, adjusted for gender, p LT 0.0001). MMP-3 genotypes and MMP-3 and -1 haplotypes encompassing either MMP-8 -799C or T alleles were associated with CAKUT and obstructive uropathies in pediatric patients. Still, functional and association studies are needed to elucidate evident roles of MMPs in CAKUT.",
journal = "Pediatric Nephrology",
title = "MMP-1 and-3 haplotype is associated with congenital anomalies of the kidney and urinary tract",
volume = "29",
number = "5",
pages = "879-884",
doi = "10.1007/s00467-013-2699-x"
}

Đurić, T., Živković, M., Milosevic, B., Anđelevski, M., Cvetković, M., Kostić, M. M.,& Stanković, A.. (2014). MMP-1 and-3 haplotype is associated with congenital anomalies of the kidney and urinary tract. in Pediatric Nephrology, 29(5), 879-884.
https://doi.org/10.1007/s00467-013-2699-x

Đurić T, Živković M, Milosevic B, Anđelevski M, Cvetković M, Kostić MM, Stanković A. MMP-1 and-3 haplotype is associated with congenital anomalies of the kidney and urinary tract. in Pediatric Nephrology. 2014;29(5):879-884.
doi:10.1007/s00467-013-2699-x .

Đurić, Tamara, Živković, Maja, Milosevic, Biljana, Anđelevski, Magdalena, Cvetković, Mirjana, Kostić, Mirjana M., Stanković, Aleksandra, "MMP-1 and-3 haplotype is associated with congenital anomalies of the kidney and urinary tract" in Pediatric Nephrology, 29, no. 5 (2014):879-884,
https://doi.org/10.1007/s00467-013-2699-x . .