TY  - JOUR
AU  - Milosavljević, Milutin M.
AU  - Vukićević Ivan M.
AU  - Serifi, Veis
AU  - Markovski, Jasmina S.
AU  - Stojiljković, Ivana
AU  - Mijin, Dušan Ž.
AU  - Marinković, Aleksandar D.
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/945
AB  - The optimized methods for N-alkyl and N,N-dialkyl substituted thioureas synthesis starting from ammonium thiocyanates, waste water constituent from the production of tetramethylthiuram monosulfide (TMTS), and alkyl amine, are presented in this work., Thioureas synthesis was developed in two ways: Method I-reaction of the thiocyanate and alkylamine in the presence of hydrochloric acid; Method II-reaction of the thiocyanate with benzoyl chloride following by amine addition in the first step, and base hydrolysis in the second step. The structure of the synthesized compounds was confirmed by IR, H-1- and C-13-NMR and MS instrumental methods, and purity was determined by high-performance liquid chromatography method. It is shown that the proposed methods offer a high degree of conversion and purity of product, absence of by-products and technological applicability at industrial scale. Considering the importance of the tetramethylthiuram disulfide (TMTD) and TMTS as vulcanization accelerators as well as thiourea as the pharmacologically active compounds, it can be said that application of the optimized methods of thiourea synthesis will provide significant improvement in sustainable development and implementation of eco-friendly production technology. The described environmentally benign process of thioureas synthesis represents a suitable option to existing methods. thioureas, industrial level, thiocyanate.
T2  - Chemical Industry and Chemical Engineering Quarterly / CICEQ
T1  - Optimization of the Synthesis of N-Alkyl and N,N-Dialkyl Thioureas from Waste Water Containing Ammonium Thiocyanate
VL  - 21
IS  - 4
SP  - 501
EP  - 510
DO  - 10.2298/CICEQ141221006M
ER  - 

@article{
author = "Milosavljević, Milutin M. and Vukićević Ivan M. and Serifi, Veis and Markovski, Jasmina S. and Stojiljković, Ivana and Mijin, Dušan Ž. and Marinković, Aleksandar D.",
year = "2015",
abstract = "The optimized methods for N-alkyl and N,N-dialkyl substituted thioureas synthesis starting from ammonium thiocyanates, waste water constituent from the production of tetramethylthiuram monosulfide (TMTS), and alkyl amine, are presented in this work., Thioureas synthesis was developed in two ways: Method I-reaction of the thiocyanate and alkylamine in the presence of hydrochloric acid; Method II-reaction of the thiocyanate with benzoyl chloride following by amine addition in the first step, and base hydrolysis in the second step. The structure of the synthesized compounds was confirmed by IR, H-1- and C-13-NMR and MS instrumental methods, and purity was determined by high-performance liquid chromatography method. It is shown that the proposed methods offer a high degree of conversion and purity of product, absence of by-products and technological applicability at industrial scale. Considering the importance of the tetramethylthiuram disulfide (TMTD) and TMTS as vulcanization accelerators as well as thiourea as the pharmacologically active compounds, it can be said that application of the optimized methods of thiourea synthesis will provide significant improvement in sustainable development and implementation of eco-friendly production technology. The described environmentally benign process of thioureas synthesis represents a suitable option to existing methods. thioureas, industrial level, thiocyanate.",
journal = "Chemical Industry and Chemical Engineering Quarterly / CICEQ",
title = "Optimization of the Synthesis of N-Alkyl and N,N-Dialkyl Thioureas from Waste Water Containing Ammonium Thiocyanate",
volume = "21",
number = "4",
pages = "501-510",
doi = "10.2298/CICEQ141221006M"
}

Milosavljević, M. M., Vukićević Ivan M., Serifi, V., Markovski, J. S., Stojiljković, I., Mijin, D. Ž.,& Marinković, A. D.. (2015). Optimization of the Synthesis of N-Alkyl and N,N-Dialkyl Thioureas from Waste Water Containing Ammonium Thiocyanate. in Chemical Industry and Chemical Engineering Quarterly / CICEQ, 21(4), 501-510.
https://doi.org/10.2298/CICEQ141221006M

Milosavljević MM, Vukićević Ivan M., Serifi V, Markovski JS, Stojiljković I, Mijin DŽ, Marinković AD. Optimization of the Synthesis of N-Alkyl and N,N-Dialkyl Thioureas from Waste Water Containing Ammonium Thiocyanate. in Chemical Industry and Chemical Engineering Quarterly / CICEQ. 2015;21(4):501-510.
doi:10.2298/CICEQ141221006M .

Milosavljević, Milutin M., Vukićević Ivan M., Serifi, Veis, Markovski, Jasmina S., Stojiljković, Ivana, Mijin, Dušan Ž., Marinković, Aleksandar D., "Optimization of the Synthesis of N-Alkyl and N,N-Dialkyl Thioureas from Waste Water Containing Ammonium Thiocyanate" in Chemical Industry and Chemical Engineering Quarterly / CICEQ, 21, no. 4 (2015):501-510,
https://doi.org/10.2298/CICEQ141221006M . .