Radojicic, Ratko

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  • Radojicic, Ratko (1)
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Fullerenol C-60(OH)(24) nanoparticles decrease relaxing effects of dimethyl sulfoxide on rat uterus spontaneous contraction

Slavic, Marija; Đorđević, Aleksandar N.; Radojicic, Ratko; Milovanović, Slobodan; Oreščanin-Dušić, Zorana S.; Rakočević, Zlatko Lj.; Spasic, Mihajlo B.; Blagojević, Duško P.

(2013)

TY  - JOUR
AU  - Slavic, Marija
AU  - Đorđević, Aleksandar N.
AU  - Radojicic, Ratko
AU  - Milovanović, Slobodan
AU  - Oreščanin-Dušić, Zorana S.
AU  - Rakočević, Zlatko Lj.
AU  - Spasic, Mihajlo B.
AU  - Blagojević, Duško P.
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5496
AB  - Dimethyl sulfoxide (DMSO) is a widely used solvent and cryoprotectant that can cause impaired blood flow, reduction in intracranial pressure, tissue edema, inflammatory reactions, inhibition of vascular smooth muscle cell migration and proliferation, processes which can lead to atherosclerosis of the coronary, peripheral and cerebral circulation. Although the adverse effects are rare when DMSO is administered in clinically established concentrations, there is no safe antagonist for an overdose. In this work, we treated isolated spontaneous and calcium-induced contractile active rat uteri (Wistar, virgo intacta), with DMSO and fullerenol C-60(OH)(24) nanoparticle (FNP) in DMSO. FNP is a water-soluble derivative of fullerene C-60. Its size is a 1.1 nm in diameter and is a very promising candidate for a drug carrier in nanomedicine. FNP also displays free radical scavenging activity. DMSO decreased both spontaneous and calcium-induced contractions. In contrast, FNP only decreased spontaneous contraction. FNP decreased copper-zinc superoxide dismutase activity and prevented the DMSO-induced increase in glutathione reductase activity. Atomic force microscopy detected that FNP aggregated with calcium ions. Our results indicate that FNP has properties that make it a good candidate to be a modulator of DMSO activity which could minimize side effects of the latter.
T2  - Journal of Nanoparticle Research
T1  - Fullerenol C-60(OH)(24) nanoparticles decrease relaxing effects of dimethyl sulfoxide on rat uterus spontaneous contraction
VL  - 15
IS  - 5
DO  - 10.1007/s11051-013-1650-1
ER  - 
@article{
author = "Slavic, Marija and Đorđević, Aleksandar N. and Radojicic, Ratko and Milovanović, Slobodan and Oreščanin-Dušić, Zorana S. and Rakočević, Zlatko Lj. and Spasic, Mihajlo B. and Blagojević, Duško P.",
year = "2013",
abstract = "Dimethyl sulfoxide (DMSO) is a widely used solvent and cryoprotectant that can cause impaired blood flow, reduction in intracranial pressure, tissue edema, inflammatory reactions, inhibition of vascular smooth muscle cell migration and proliferation, processes which can lead to atherosclerosis of the coronary, peripheral and cerebral circulation. Although the adverse effects are rare when DMSO is administered in clinically established concentrations, there is no safe antagonist for an overdose. In this work, we treated isolated spontaneous and calcium-induced contractile active rat uteri (Wistar, virgo intacta), with DMSO and fullerenol C-60(OH)(24) nanoparticle (FNP) in DMSO. FNP is a water-soluble derivative of fullerene C-60. Its size is a 1.1 nm in diameter and is a very promising candidate for a drug carrier in nanomedicine. FNP also displays free radical scavenging activity. DMSO decreased both spontaneous and calcium-induced contractions. In contrast, FNP only decreased spontaneous contraction. FNP decreased copper-zinc superoxide dismutase activity and prevented the DMSO-induced increase in glutathione reductase activity. Atomic force microscopy detected that FNP aggregated with calcium ions. Our results indicate that FNP has properties that make it a good candidate to be a modulator of DMSO activity which could minimize side effects of the latter.",
journal = "Journal of Nanoparticle Research",
title = "Fullerenol C-60(OH)(24) nanoparticles decrease relaxing effects of dimethyl sulfoxide on rat uterus spontaneous contraction",
volume = "15",
number = "5",
doi = "10.1007/s11051-013-1650-1"
}
Slavic, M., Đorđević, A. N., Radojicic, R., Milovanović, S., Oreščanin-Dušić, Z. S., Rakočević, Z. Lj., Spasic, M. B.,& Blagojević, D. P.. (2013). Fullerenol C-60(OH)(24) nanoparticles decrease relaxing effects of dimethyl sulfoxide on rat uterus spontaneous contraction. in Journal of Nanoparticle Research, 15(5).
https://doi.org/10.1007/s11051-013-1650-1
Slavic M, Đorđević AN, Radojicic R, Milovanović S, Oreščanin-Dušić ZS, Rakočević ZL, Spasic MB, Blagojević DP. Fullerenol C-60(OH)(24) nanoparticles decrease relaxing effects of dimethyl sulfoxide on rat uterus spontaneous contraction. in Journal of Nanoparticle Research. 2013;15(5).
doi:10.1007/s11051-013-1650-1 .
Slavic, Marija, Đorđević, Aleksandar N., Radojicic, Ratko, Milovanović, Slobodan, Oreščanin-Dušić, Zorana S., Rakočević, Zlatko Lj., Spasic, Mihajlo B., Blagojević, Duško P., "Fullerenol C-60(OH)(24) nanoparticles decrease relaxing effects of dimethyl sulfoxide on rat uterus spontaneous contraction" in Journal of Nanoparticle Research, 15, no. 5 (2013),
https://doi.org/10.1007/s11051-013-1650-1 . .
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