@article{
author = "Novaković, Slađana B. and Bogdanović, Goran A. and Ratković, Zoran and Blagojević, Stefan and Matić, Sanja Lj. and Muškinja, Jovana",
year = "2024",
abstract = "Two series of new ferrocenyl pyrazolines have been synthesized by the reac-tion of ferrocenyl chalcones and their analogues with hydrazine hydrate in thepresence of corresponding carboxylic acid. Single-crystal X-ray crystallographicdata were used for detailed analysis of the interesting versatility of four com-pounds in the formation of intermolecular interactions. The analysis revealedan excellent structural flexibility of the present ferrocenyl pyrazoline moleculesfor the non-covalent interactions, with a particular contribution of the ferro-cene units. In addition, for comparison with crystallographic findings, weinvestigated the protective effect of all compounds on DNA against hydroxyland peroxyl radicals induced by Fe2+,H2O2, and 2,20-azobis(2-amidinopro-pane) dihydrochloride (AAPH). The results indicated that all compoundsshowed rather similar DNA protective activity, which was comparable withquercetin as a well-known protective compound. This similarity in antigeno-toxic action could be explained by the established excellent structural flexibil-ity of ferrocenyl pyrazolines for the formation of different intermolecularinteractions as important structural property for molecular recognition.",
journal = "Applied Organometallic Chemistry",
title = "Synthesis, structural properties and DNA protective activity of ferrocenyl N-acyl pyrazolines",
doi = "10.1002/aoc.7464"
}