TY  - JOUR
AU  - Matijević, Milica
AU  - Žakula, Jelena
AU  - Korićanac, Lela
AU  - Radoičić, Marija B.
AU  - Liang, Xinyue
AU  - Mi, Lan
AU  - Filipović Tričković, Jelena G.
AU  - Valenta-Šobot, Ana
AU  - Stanković, Maja N.
AU  - Nakarada, Đura
AU  - Mojović, Miloš
AU  - Petković, Marijana
AU  - Stepić, Milutin
AU  - Nešić, Maja D.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9908
AB  - In this study, C-doped TiO2 nanoparticles (C-TiO2) were prepared and tested as a photosensitizer for visible-light-driven photodynamic therapy against cervical cancer cells (HeLa). X-ray diffraction and Transmission Electron Microscopy confirmed the anatase form of nanoparticles, spherical shape, and size distribution from 5 to 15 nm. Ultraviolet–visible light spectroscopy showed that C doping of TiO2 enhances the optical absorption in the visible light range caused by a bandgap narrowing. The photo-cytotoxic activity of C-TiO2 was investigated in vitro against HeLa cells. The lack of dark cytotoxicity indicates good biocompatibility of C-TiO2. In contrast, a combination with blue light significantly reduced the survival of HeLa cells: illumination only decreased cell viability by 30% (15 min of illumination, 120 µW power), and 60% when HeLa cells were preincubated with C-TiO2. We have also confirmed blue light-induced C-TiO2-catalyzed generation of reactive oxygen species in vitro and intracellularly. Oxidative stress triggered by C-TiO2/blue light was the leading cause of HeLa cell death. Fluorescent labeling of treated HeLa cells showed distinct morphological changes after the C-TiO2/blue light treatment. Unlike blue light illumination, which caused the appearance of large necrotic cells with deformed nuclei, cytoplasm swelling, and membrane blebbing, a combination of C-TiO2/blue light leads to controlled cell death, thus providing a better outcome of local anticancer therapy.
T2  - Photochemical and Photobiological Sciences
T1  - Controlled killing of human cervical cancer cells by combined action of blue light and C-doped TiO2 nanoparticles
VL  - 20
IS  - 8
SP  - 1087
EP  - 1098
DO  - 10.1007/s43630-021-00082-2
ER  - 

@article{
author = "Matijević, Milica and Žakula, Jelena and Korićanac, Lela and Radoičić, Marija B. and Liang, Xinyue and Mi, Lan and Filipović Tričković, Jelena G. and Valenta-Šobot, Ana and Stanković, Maja N. and Nakarada, Đura and Mojović, Miloš and Petković, Marijana and Stepić, Milutin and Nešić, Maja D.",
year = "2021",
abstract = "In this study, C-doped TiO2 nanoparticles (C-TiO2) were prepared and tested as a photosensitizer for visible-light-driven photodynamic therapy against cervical cancer cells (HeLa). X-ray diffraction and Transmission Electron Microscopy confirmed the anatase form of nanoparticles, spherical shape, and size distribution from 5 to 15 nm. Ultraviolet–visible light spectroscopy showed that C doping of TiO2 enhances the optical absorption in the visible light range caused by a bandgap narrowing. The photo-cytotoxic activity of C-TiO2 was investigated in vitro against HeLa cells. The lack of dark cytotoxicity indicates good biocompatibility of C-TiO2. In contrast, a combination with blue light significantly reduced the survival of HeLa cells: illumination only decreased cell viability by 30% (15 min of illumination, 120 µW power), and 60% when HeLa cells were preincubated with C-TiO2. We have also confirmed blue light-induced C-TiO2-catalyzed generation of reactive oxygen species in vitro and intracellularly. Oxidative stress triggered by C-TiO2/blue light was the leading cause of HeLa cell death. Fluorescent labeling of treated HeLa cells showed distinct morphological changes after the C-TiO2/blue light treatment. Unlike blue light illumination, which caused the appearance of large necrotic cells with deformed nuclei, cytoplasm swelling, and membrane blebbing, a combination of C-TiO2/blue light leads to controlled cell death, thus providing a better outcome of local anticancer therapy.",
journal = "Photochemical and Photobiological Sciences",
title = "Controlled killing of human cervical cancer cells by combined action of blue light and C-doped TiO2 nanoparticles",
volume = "20",
number = "8",
pages = "1087-1098",
doi = "10.1007/s43630-021-00082-2"
}

Matijević, M., Žakula, J., Korićanac, L., Radoičić, M. B., Liang, X., Mi, L., Filipović Tričković, J. G., Valenta-Šobot, A., Stanković, M. N., Nakarada, Đ., Mojović, M., Petković, M., Stepić, M.,& Nešić, M. D.. (2021). Controlled killing of human cervical cancer cells by combined action of blue light and C-doped TiO2 nanoparticles. in Photochemical and Photobiological Sciences, 20(8), 1087-1098.
https://doi.org/10.1007/s43630-021-00082-2

Matijević M, Žakula J, Korićanac L, Radoičić MB, Liang X, Mi L, Filipović Tričković JG, Valenta-Šobot A, Stanković MN, Nakarada Đ, Mojović M, Petković M, Stepić M, Nešić MD. Controlled killing of human cervical cancer cells by combined action of blue light and C-doped TiO2 nanoparticles. in Photochemical and Photobiological Sciences. 2021;20(8):1087-1098.
doi:10.1007/s43630-021-00082-2 .

Matijević, Milica, Žakula, Jelena, Korićanac, Lela, Radoičić, Marija B., Liang, Xinyue, Mi, Lan, Filipović Tričković, Jelena G., Valenta-Šobot, Ana, Stanković, Maja N., Nakarada, Đura, Mojović, Miloš, Petković, Marijana, Stepić, Milutin, Nešić, Maja D., "Controlled killing of human cervical cancer cells by combined action of blue light and C-doped TiO2 nanoparticles" in Photochemical and Photobiological Sciences, 20, no. 8 (2021):1087-1098,
https://doi.org/10.1007/s43630-021-00082-2 . .

TY  - JOUR
AU  - Matijević, Milica
AU  - Stanković, Maja N.
AU  - Krstić, Nenad S.
AU  - Nikolić, Milica G.
AU  - Kostić, Danijela A.
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9665
AB  - Natural phenolic compounds are significant component of the human diet, as they are present in fruits and vegetables, and they have very important biological activity in the living organisms. Because of their structure, they are subject of numerous oxidation processes, such as autoxidation, but are easily to oxidize in presence of various oxidizing agents and enzymes. Many authors have been investigating phenolic oxidation processes, and have successfully identified their pathways and a significant number of intermediates and products generated by these processes. Also, particular attention has been made to the effects of these processes on food quality and other biological processes in living organisms. Phenols are persistent pollutants of water systems from various agricultural activities and industrial wastewater discharges. It is known that the presence of phenolic compounds in water supplies and industrial effluents directly affects natural processes in the environment due to their toxicity and natural ability to decompose. This property, to easily oxidize and, as a result of it, to mineralize, is practically useful for the treatment of the wastewaters, so it is of global concern to manage the best technology to remove phenols and other organic pollutants, assisted with the oxidation processes. In the aspect of treatment of wastewaters polluted with phenols, we reviewed oxidative processes such as autoxidation, enzyme-catalyzed oxidation, photo-oxidation, electrochemical oxidation and oxidation by Fenton's reagent and, based on the literature data, we presented advantages and disadvantages of these processes compared to each other. © 2020 Editura Academiei Romane. All rights reserved.
T2  - Revue Roumaine de Chimie
T1  - Application of oxidation processes in the purification of wastewaters from phenolic compounds
VL  - 65
IS  - 4
SP  - 313
EP  - 327
DO  - 10.33224/rrch.2020.65.4.01
ER  - 

@article{
author = "Matijević, Milica and Stanković, Maja N. and Krstić, Nenad S. and Nikolić, Milica G. and Kostić, Danijela A.",
year = "2020",
abstract = "Natural phenolic compounds are significant component of the human diet, as they are present in fruits and vegetables, and they have very important biological activity in the living organisms. Because of their structure, they are subject of numerous oxidation processes, such as autoxidation, but are easily to oxidize in presence of various oxidizing agents and enzymes. Many authors have been investigating phenolic oxidation processes, and have successfully identified their pathways and a significant number of intermediates and products generated by these processes. Also, particular attention has been made to the effects of these processes on food quality and other biological processes in living organisms. Phenols are persistent pollutants of water systems from various agricultural activities and industrial wastewater discharges. It is known that the presence of phenolic compounds in water supplies and industrial effluents directly affects natural processes in the environment due to their toxicity and natural ability to decompose. This property, to easily oxidize and, as a result of it, to mineralize, is practically useful for the treatment of the wastewaters, so it is of global concern to manage the best technology to remove phenols and other organic pollutants, assisted with the oxidation processes. In the aspect of treatment of wastewaters polluted with phenols, we reviewed oxidative processes such as autoxidation, enzyme-catalyzed oxidation, photo-oxidation, electrochemical oxidation and oxidation by Fenton's reagent and, based on the literature data, we presented advantages and disadvantages of these processes compared to each other. © 2020 Editura Academiei Romane. All rights reserved.",
journal = "Revue Roumaine de Chimie",
title = "Application of oxidation processes in the purification of wastewaters from phenolic compounds",
volume = "65",
number = "4",
pages = "313-327",
doi = "10.33224/rrch.2020.65.4.01"
}

Matijević, M., Stanković, M. N., Krstić, N. S., Nikolić, M. G.,& Kostić, D. A.. (2020). Application of oxidation processes in the purification of wastewaters from phenolic compounds. in Revue Roumaine de Chimie, 65(4), 313-327.
https://doi.org/10.33224/rrch.2020.65.4.01

Matijević M, Stanković MN, Krstić NS, Nikolić MG, Kostić DA. Application of oxidation processes in the purification of wastewaters from phenolic compounds. in Revue Roumaine de Chimie. 2020;65(4):313-327.
doi:10.33224/rrch.2020.65.4.01 .

Matijević, Milica, Stanković, Maja N., Krstić, Nenad S., Nikolić, Milica G., Kostić, Danijela A., "Application of oxidation processes in the purification of wastewaters from phenolic compounds" in Revue Roumaine de Chimie, 65, no. 4 (2020):313-327,
https://doi.org/10.33224/rrch.2020.65.4.01 . .