TY  - JOUR
AU  - Jakovljević, Ivan
AU  - Petrović, Đorđe
AU  - Joksović, Ljubinka G.
AU  - Lazarević, Ivan
AU  - Jelikić-Stankov, Milena
AU  - Đurđević, Predrag
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/833
AB  - Complex formation equilibria of aluminum(III), gadolinium(III), and yttrium(III) ions with the fluoroquinolone antibacterials moxifloxacin, ofloxacin, fleroxacin, lomefloxacin, levofloxacin, and ciprofloxacin were studied in aqueous solution by potentiometric and spectroscopic methods. The identity and stability of metal-fluoroquinolone complexes were determined by analyzing potentiometric titration curves (310K, =0.15M NaCl, pH range=2-11, C-L/C-M=1:1 to 3:1, C-M=1.0mM) with the aid of Hyperquad2006 program. The main species formed in the system may be formulated as MpHqLr (p=1, q=-2 to 2, r=1-3, L=fluoroquinolone anion, logarithm of overall stability constant, log (p,q,r)=in the range ca. -10 to 45). The stability of complexes is mostly influenced by metal ion properties (ionization potential, ionic radius) indicating partial ionic character of the coordination bond. The complexes were also characterized by spectroscopic measurements: spectrofluorimetry, H-1-NMR, and ESI-MS. Fluorimetric data were evaluated with the aid of HypSpec2014 and indicated the formation of MLr (r=1-3) complexes with cumulative conditional stability constants significantly lower than the thermodynamic ones. NMR and MS data corroborate potentiometrically determined speciation. Calculated plasma mobilizing capacity of the ligands generally follows the order levofloxacin GT moxifloxacin GT ciprofloxacin at concentration levels of the ligands higher or equal to ca. 10(-4)M.
PB  - Taylor & Francis
T2  - Journal of Coordination Chemistry
T1  - Complex formation equilibria between aluminum(III), gadolinium(III) and yttrium(III) ions and some fluoroquinolone ligands. Potentiometric and spectroscopic study
VL  - 68
IS  - 24
SP  - 4272
EP  - 4295
DO  - 10.1080/00958972.2015.1089535
ER  - 

@article{
author = "Jakovljević, Ivan and Petrović, Đorđe and Joksović, Ljubinka G. and Lazarević, Ivan and Jelikić-Stankov, Milena and Đurđević, Predrag",
year = "2015",
abstract = "Complex formation equilibria of aluminum(III), gadolinium(III), and yttrium(III) ions with the fluoroquinolone antibacterials moxifloxacin, ofloxacin, fleroxacin, lomefloxacin, levofloxacin, and ciprofloxacin were studied in aqueous solution by potentiometric and spectroscopic methods. The identity and stability of metal-fluoroquinolone complexes were determined by analyzing potentiometric titration curves (310K, =0.15M NaCl, pH range=2-11, C-L/C-M=1:1 to 3:1, C-M=1.0mM) with the aid of Hyperquad2006 program. The main species formed in the system may be formulated as MpHqLr (p=1, q=-2 to 2, r=1-3, L=fluoroquinolone anion, logarithm of overall stability constant, log (p,q,r)=in the range ca. -10 to 45). The stability of complexes is mostly influenced by metal ion properties (ionization potential, ionic radius) indicating partial ionic character of the coordination bond. The complexes were also characterized by spectroscopic measurements: spectrofluorimetry, H-1-NMR, and ESI-MS. Fluorimetric data were evaluated with the aid of HypSpec2014 and indicated the formation of MLr (r=1-3) complexes with cumulative conditional stability constants significantly lower than the thermodynamic ones. NMR and MS data corroborate potentiometrically determined speciation. Calculated plasma mobilizing capacity of the ligands generally follows the order levofloxacin GT moxifloxacin GT ciprofloxacin at concentration levels of the ligands higher or equal to ca. 10(-4)M.",
publisher = "Taylor & Francis",
journal = "Journal of Coordination Chemistry",
title = "Complex formation equilibria between aluminum(III), gadolinium(III) and yttrium(III) ions and some fluoroquinolone ligands. Potentiometric and spectroscopic study",
volume = "68",
number = "24",
pages = "4272-4295",
doi = "10.1080/00958972.2015.1089535"
}

Jakovljević, I., Petrović, Đ., Joksović, L. G., Lazarević, I., Jelikić-Stankov, M.,& Đurđević, P.. (2015). Complex formation equilibria between aluminum(III), gadolinium(III) and yttrium(III) ions and some fluoroquinolone ligands. Potentiometric and spectroscopic study. in Journal of Coordination Chemistry
Taylor & Francis., 68(24), 4272-4295.
https://doi.org/10.1080/00958972.2015.1089535

Jakovljević I, Petrović Đ, Joksović LG, Lazarević I, Jelikić-Stankov M, Đurđević P. Complex formation equilibria between aluminum(III), gadolinium(III) and yttrium(III) ions and some fluoroquinolone ligands. Potentiometric and spectroscopic study. in Journal of Coordination Chemistry. 2015;68(24):4272-4295.
doi:10.1080/00958972.2015.1089535 .

Jakovljević, Ivan, Petrović, Đorđe, Joksović, Ljubinka G., Lazarević, Ivan, Jelikić-Stankov, Milena, Đurđević, Predrag, "Complex formation equilibria between aluminum(III), gadolinium(III) and yttrium(III) ions and some fluoroquinolone ligands. Potentiometric and spectroscopic study" in Journal of Coordination Chemistry, 68, no. 24 (2015):4272-4295,
https://doi.org/10.1080/00958972.2015.1089535 . .