TY  - JOUR
AU  - Đurašević, Siniša
AU  - Pejić, Snežana
AU  - Grigorov, Ilijana
AU  - Nikolić, Gorana
AU  - Mitić-Ćulafić, Dragana
AU  - Dragićević, Milan
AU  - Đorđević, Jelena
AU  - Todorović Vukotić, Nevena
AU  - Đorđević, Neda O.
AU  - Todorović, Ana
AU  - Drakulić, Dunja R.
AU  - Veljković, Filip M.
AU  - Pajović, Snežana B.
AU  - Todorović, Zoran
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9831
AB  - Thioacetamide (TAA) is widely used to study liver toxicity accompanied by oxidative stress, inflammation, cell necrosis, fibrosis, cholestasis, and hepatocellular carcinoma. As an efficient free radical’s scavenger, C60 fullerene is considered a potential liver-protective agent in chemically-induced liver injury. In the present work, we examined the hepatoprotective effects of two C60 doses dissolved in virgin olive oil against TAA-induced hepatotoxicity in rats. We showed that TAA-induced increase in liver oxidative stress, judged by the changes in the activities of SOD, CAT, GPx, GR, GST, the content of GSH and 4-HNE, and expression of HO-1, MnSOD, and CuZnSOD, was more effectively ameliorated with a lower C60 dose. Improvement in liver antioxidative status caused by C60 was accompanied by a decrease in liver HMGB1 expression and an increase in nuclear Nrf2/NF-κB p65 ratio, suggesting a reduction in inflammation, necrosis and fibrosis. These results were in accordance with liver histology analysis, liver comet assay, and changes in serum levels of ALT, AST, and AP. The changes observed in gut microbiome support detrimental effects of TAA and hepatoprotective effects of low C60 dose. Less protective effects of a higher C60 dose could be a consequence of its enhanced aggregation and related pro-oxidant role.
T2  - Antioxidants
T1  - Effects of C60 Fullerene on Thioacetamide-Induced Rat Liver Toxicity and Gut Microbiome Changes
VL  - 10
IS  - 6
SP  - 911
DO  - 10.3390/antiox10060911
ER  - 

@article{
author = "Đurašević, Siniša and Pejić, Snežana and Grigorov, Ilijana and Nikolić, Gorana and Mitić-Ćulafić, Dragana and Dragićević, Milan and Đorđević, Jelena and Todorović Vukotić, Nevena and Đorđević, Neda O. and Todorović, Ana and Drakulić, Dunja R. and Veljković, Filip M. and Pajović, Snežana B. and Todorović, Zoran",
year = "2021",
abstract = "Thioacetamide (TAA) is widely used to study liver toxicity accompanied by oxidative stress, inflammation, cell necrosis, fibrosis, cholestasis, and hepatocellular carcinoma. As an efficient free radical’s scavenger, C60 fullerene is considered a potential liver-protective agent in chemically-induced liver injury. In the present work, we examined the hepatoprotective effects of two C60 doses dissolved in virgin olive oil against TAA-induced hepatotoxicity in rats. We showed that TAA-induced increase in liver oxidative stress, judged by the changes in the activities of SOD, CAT, GPx, GR, GST, the content of GSH and 4-HNE, and expression of HO-1, MnSOD, and CuZnSOD, was more effectively ameliorated with a lower C60 dose. Improvement in liver antioxidative status caused by C60 was accompanied by a decrease in liver HMGB1 expression and an increase in nuclear Nrf2/NF-κB p65 ratio, suggesting a reduction in inflammation, necrosis and fibrosis. These results were in accordance with liver histology analysis, liver comet assay, and changes in serum levels of ALT, AST, and AP. The changes observed in gut microbiome support detrimental effects of TAA and hepatoprotective effects of low C60 dose. Less protective effects of a higher C60 dose could be a consequence of its enhanced aggregation and related pro-oxidant role.",
journal = "Antioxidants",
title = "Effects of C60 Fullerene on Thioacetamide-Induced Rat Liver Toxicity and Gut Microbiome Changes",
volume = "10",
number = "6",
pages = "911",
doi = "10.3390/antiox10060911"
}

Đurašević, S., Pejić, S., Grigorov, I., Nikolić, G., Mitić-Ćulafić, D., Dragićević, M., Đorđević, J., Todorović Vukotić, N., Đorđević, N. O., Todorović, A., Drakulić, D. R., Veljković, F. M., Pajović, S. B.,& Todorović, Z.. (2021). Effects of C60 Fullerene on Thioacetamide-Induced Rat Liver Toxicity and Gut Microbiome Changes. in Antioxidants, 10(6), 911.
https://doi.org/10.3390/antiox10060911

Đurašević S, Pejić S, Grigorov I, Nikolić G, Mitić-Ćulafić D, Dragićević M, Đorđević J, Todorović Vukotić N, Đorđević NO, Todorović A, Drakulić DR, Veljković FM, Pajović SB, Todorović Z. Effects of C60 Fullerene on Thioacetamide-Induced Rat Liver Toxicity and Gut Microbiome Changes. in Antioxidants. 2021;10(6):911.
doi:10.3390/antiox10060911 .

Đurašević, Siniša, Pejić, Snežana, Grigorov, Ilijana, Nikolić, Gorana, Mitić-Ćulafić, Dragana, Dragićević, Milan, Đorđević, Jelena, Todorović Vukotić, Nevena, Đorđević, Neda O., Todorović, Ana, Drakulić, Dunja R., Veljković, Filip M., Pajović, Snežana B., Todorović, Zoran, "Effects of C60 Fullerene on Thioacetamide-Induced Rat Liver Toxicity and Gut Microbiome Changes" in Antioxidants, 10, no. 6 (2021):911,
https://doi.org/10.3390/antiox10060911 . .

TY  - CONF
AU  - Adžić, Miroslav
AU  - Đorđević, Ana D.
AU  - Đorđević, Jelena
AU  - Elaković, Ivana
AU  - Simić, Iva
AU  - Mitić, Miloš
AU  - Rackov, Gorjana
AU  - Matić, Gordana
AU  - Radojčić, Marija
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9306
AB  - Alterations in the antioxidative defense parameters upon chronic stress are considered
critical for pathophysiology of stress related psychiatric disorders and their status in
blood serves as biomarker for effects of pharmacological treatments. We investigated
the modulation of erythrocyte antioxidant enzymes (AOEs): superoxide dismutase
(SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GLR)
protein expression and activity in Wistar male rats subjected to chronic psychosocial
isolation and/or treated with fluoxetine. Chronically isolated animals exhibited
decreased levels of plasma corticoserone (CORT). AOEs status was not altered either
by chronic social isolation or by fluoxetine. The only exception was GLR, whose level
and activity were both markedly reduced by fluoxetine. Our study indicates that
fluoxetine treatment of chronically isolated male Wistar rats, leads to significant
reduction in the level and activity of GLR in the erythrocytes.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry
T1  - Fluoxetine decreases glutathione reductase in erythrocytes of chronically isolated wistar rats
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9306
ER  - 

@conference{
author = "Adžić, Miroslav and Đorđević, Ana D. and Đorđević, Jelena and Elaković, Ivana and Simić, Iva and Mitić, Miloš and Rackov, Gorjana and Matić, Gordana and Radojčić, Marija",
year = "2010",
abstract = "Alterations in the antioxidative defense parameters upon chronic stress are considered
critical for pathophysiology of stress related psychiatric disorders and their status in
blood serves as biomarker for effects of pharmacological treatments. We investigated
the modulation of erythrocyte antioxidant enzymes (AOEs): superoxide dismutase
(SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GLR)
protein expression and activity in Wistar male rats subjected to chronic psychosocial
isolation and/or treated with fluoxetine. Chronically isolated animals exhibited
decreased levels of plasma corticoserone (CORT). AOEs status was not altered either
by chronic social isolation or by fluoxetine. The only exception was GLR, whose level
and activity were both markedly reduced by fluoxetine. Our study indicates that
fluoxetine treatment of chronically isolated male Wistar rats, leads to significant
reduction in the level and activity of GLR in the erythrocytes.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry",
title = "Fluoxetine decreases glutathione reductase in erythrocytes of chronically isolated wistar rats",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9306"
}

Adžić, M., Đorđević, A. D., Đorđević, J., Elaković, I., Simić, I., Mitić, M., Rackov, G., Matić, G.,& Radojčić, M.. (2010). Fluoxetine decreases glutathione reductase in erythrocytes of chronically isolated wistar rats. in Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry
Society of Physical Chemists of Serbia..
https://hdl.handle.net/21.15107/rcub_vinar_9306

Adžić M, Đorđević AD, Đorđević J, Elaković I, Simić I, Mitić M, Rackov G, Matić G, Radojčić M. Fluoxetine decreases glutathione reductase in erythrocytes of chronically isolated wistar rats. in Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry. 2010;.
https://hdl.handle.net/21.15107/rcub_vinar_9306 .

Adžić, Miroslav, Đorđević, Ana D., Đorđević, Jelena, Elaković, Ivana, Simić, Iva, Mitić, Miloš, Rackov, Gorjana, Matić, Gordana, Radojčić, Marija, "Fluoxetine decreases glutathione reductase in erythrocytes of chronically isolated wistar rats" in Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry (2010),
https://hdl.handle.net/21.15107/rcub_vinar_9306 .