TY  - JOUR
AU  - Glumac, Sofija
AU  - Pejić, Snežana
AU  - Kovačević, Relja Z.
AU  - Dunđerović, Duško
AU  - Davidović, Radoslav S.
AU  - Ristić, Dalibor, V
AU  - Sopta, Josipa
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/835
AB  - Rhabdomyosarcoma (RMS) is a highly malignant cancer. Over the last two decades, prognosis for RMS patients has significantly improved, with the exception of those in the high-risk group. In order to identify new prognostic factors, we investigated the expression of nestin in RMS cells and its correlation with clinicopathological features and patient outcome. The analysis of overall survival for all patients (N = 30) revealed 1-, 2-, 3-, 4-, and 5-year survival rates of 93.3, 83.3, 66.7, 63.3, and 63.3%, respectively. Nestin overexpression significantly correlated with survival (P = 0.044). Survival of patients with = 50% nestin-positive cells was 90, 70, and 40% after 1, 2, and 3 years, respectively, and remained unchanged until the end of the investigation period. The study group composed of patients exhibiting nestin expression in GT 50% of cells showed 1-, 2-, 3-, and 4-year survival rates of 95, 90, 80, and 75%, respectively, remaining stable at 75% for the fifth year of observation. A nestin-positive expression rate lower than 50% was observed more frequently in older patients (43.60 +/- 27.58 years; P = 0.028). In addition, higher rates of nestin expression were observed in most embryonal RMS specimens and low-grade tumors, in early stages of the disease, and among younger patients. Our results lead us to propose nestin as possible positive prognostic factor in RMS.
T2  - Genetics and Molecular Research
T1  - Immunohistochemical expression of nestin in rhabdomyosarcoma: implications for clinicopathology and patient outcome
VL  - 14
IS  - 4
SP  - 14649
EP  - 14659
DO  - 10.4238/2015.November.18.29
ER  - 

@article{
author = "Glumac, Sofija and Pejić, Snežana and Kovačević, Relja Z. and Dunđerović, Duško and Davidović, Radoslav S. and Ristić, Dalibor, V and Sopta, Josipa",
year = "2015",
abstract = "Rhabdomyosarcoma (RMS) is a highly malignant cancer. Over the last two decades, prognosis for RMS patients has significantly improved, with the exception of those in the high-risk group. In order to identify new prognostic factors, we investigated the expression of nestin in RMS cells and its correlation with clinicopathological features and patient outcome. The analysis of overall survival for all patients (N = 30) revealed 1-, 2-, 3-, 4-, and 5-year survival rates of 93.3, 83.3, 66.7, 63.3, and 63.3%, respectively. Nestin overexpression significantly correlated with survival (P = 0.044). Survival of patients with = 50% nestin-positive cells was 90, 70, and 40% after 1, 2, and 3 years, respectively, and remained unchanged until the end of the investigation period. The study group composed of patients exhibiting nestin expression in GT 50% of cells showed 1-, 2-, 3-, and 4-year survival rates of 95, 90, 80, and 75%, respectively, remaining stable at 75% for the fifth year of observation. A nestin-positive expression rate lower than 50% was observed more frequently in older patients (43.60 +/- 27.58 years; P = 0.028). In addition, higher rates of nestin expression were observed in most embryonal RMS specimens and low-grade tumors, in early stages of the disease, and among younger patients. Our results lead us to propose nestin as possible positive prognostic factor in RMS.",
journal = "Genetics and Molecular Research",
title = "Immunohistochemical expression of nestin in rhabdomyosarcoma: implications for clinicopathology and patient outcome",
volume = "14",
number = "4",
pages = "14649-14659",
doi = "10.4238/2015.November.18.29"
}

Glumac, S., Pejić, S., Kovačević, R. Z., Dunđerović, D., Davidović, R. S., Ristić, D. V.,& Sopta, J.. (2015). Immunohistochemical expression of nestin in rhabdomyosarcoma: implications for clinicopathology and patient outcome. in Genetics and Molecular Research, 14(4), 14649-14659.
https://doi.org/10.4238/2015.November.18.29

Glumac S, Pejić S, Kovačević RZ, Dunđerović D, Davidović RS, Ristić DV, Sopta J. Immunohistochemical expression of nestin in rhabdomyosarcoma: implications for clinicopathology and patient outcome. in Genetics and Molecular Research. 2015;14(4):14649-14659.
doi:10.4238/2015.November.18.29 .

Glumac, Sofija, Pejić, Snežana, Kovačević, Relja Z., Dunđerović, Duško, Davidović, Radoslav S., Ristić, Dalibor, V, Sopta, Josipa, "Immunohistochemical expression of nestin in rhabdomyosarcoma: implications for clinicopathology and patient outcome" in Genetics and Molecular Research, 14, no. 4 (2015):14649-14659,
https://doi.org/10.4238/2015.November.18.29 . .