TY  - JOUR
AU  - Ćirin-Varađan, Slobodanka
AU  - Đuriš, Jelena
AU  - Mirković, Miljana M.
AU  - Ivanović, Marija M.
AU  - Parojčić, Jelena
AU  - Aleksić, Ivana
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10074
AB  - The introduction of the high-speed tableting machines and the lack of excipients with good flow and compaction properties required for direct compression process have increased research interest in the development of co-processed excipients. Melt granulation, as an environmentally friendly and cost-effective method, has recently been recognized as a promising co-processing technique. The aim of the present study was to prepare lipid-based co-processed excipients by in situ fluidized bed melt granulation and to investigated their suitability for direct compression process. Lactose monohydrate was co-processed with glyceryl dibehenate (Compritol® 888 ATO) or glyceryl palmitostearate (Precirol® ATO 5), as lipophilic meltable binders. Besides the flowability testing, dynamic compaction analysis was applied for thorough investigation into the tableting properties of developed co-processed excipients. Solid state characterization, performed by means of XRPD and DRIFT, confirmed the absence of chemical changes of the single components of co-processed excipients. Co-processed excipients showed improved flowability in comparison with single ingredients and corresponding physical mixtures. Novel co-processed excipients were found to have better tabletability profiles than physical mixtures of the ingredients, and were able to retain acceptable tensile strength values at high content of paracetamol in tableting mixture. Tablets with high tensile strength could be obtained with less work of compression needed in comparison with the commercial lactose-based excipients. Furthermore, novel lipid-based co-processed excipients were found to be highly superior regarding the antiadhesive and lubricating properties, with no additional lubricants required.
T2  - Journal of Drug Delivery Science and Technology
T1  - Comparative evaluation of mechanical properties of lactose-based excipients co-processed with lipophilic glycerides as meltable binders
SP  - 102981
DO  - 10.1016/j.jddst.2021.102981
ER  - 

@article{
author = "Ćirin-Varađan, Slobodanka and Đuriš, Jelena and Mirković, Miljana M. and Ivanović, Marija M. and Parojčić, Jelena and Aleksić, Ivana",
year = "2021",
abstract = "The introduction of the high-speed tableting machines and the lack of excipients with good flow and compaction properties required for direct compression process have increased research interest in the development of co-processed excipients. Melt granulation, as an environmentally friendly and cost-effective method, has recently been recognized as a promising co-processing technique. The aim of the present study was to prepare lipid-based co-processed excipients by in situ fluidized bed melt granulation and to investigated their suitability for direct compression process. Lactose monohydrate was co-processed with glyceryl dibehenate (Compritol® 888 ATO) or glyceryl palmitostearate (Precirol® ATO 5), as lipophilic meltable binders. Besides the flowability testing, dynamic compaction analysis was applied for thorough investigation into the tableting properties of developed co-processed excipients. Solid state characterization, performed by means of XRPD and DRIFT, confirmed the absence of chemical changes of the single components of co-processed excipients. Co-processed excipients showed improved flowability in comparison with single ingredients and corresponding physical mixtures. Novel co-processed excipients were found to have better tabletability profiles than physical mixtures of the ingredients, and were able to retain acceptable tensile strength values at high content of paracetamol in tableting mixture. Tablets with high tensile strength could be obtained with less work of compression needed in comparison with the commercial lactose-based excipients. Furthermore, novel lipid-based co-processed excipients were found to be highly superior regarding the antiadhesive and lubricating properties, with no additional lubricants required.",
journal = "Journal of Drug Delivery Science and Technology",
title = "Comparative evaluation of mechanical properties of lactose-based excipients co-processed with lipophilic glycerides as meltable binders",
pages = "102981",
doi = "10.1016/j.jddst.2021.102981"
}

Ćirin-Varađan, S., Đuriš, J., Mirković, M. M., Ivanović, M. M., Parojčić, J.,& Aleksić, I.. (2021). Comparative evaluation of mechanical properties of lactose-based excipients co-processed with lipophilic glycerides as meltable binders. in Journal of Drug Delivery Science and Technology, 102981.
https://doi.org/10.1016/j.jddst.2021.102981

Ćirin-Varađan S, Đuriš J, Mirković MM, Ivanović MM, Parojčić J, Aleksić I. Comparative evaluation of mechanical properties of lactose-based excipients co-processed with lipophilic glycerides as meltable binders. in Journal of Drug Delivery Science and Technology. 2021;:102981.
doi:10.1016/j.jddst.2021.102981 .

Ćirin-Varađan, Slobodanka, Đuriš, Jelena, Mirković, Miljana M., Ivanović, Marija M., Parojčić, Jelena, Aleksić, Ivana, "Comparative evaluation of mechanical properties of lactose-based excipients co-processed with lipophilic glycerides as meltable binders" in Journal of Drug Delivery Science and Technology (2021):102981,
https://doi.org/10.1016/j.jddst.2021.102981 . .

TY  - JOUR
AU  - Milošević, Nenad D.
AU  - Aleksić, Ivana
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4936
AB  - This paper presents experimental results on thermophysical properties of the most commonly used titanium alloy, Ti-6Al-4V, in its solid phase. The subsecond pulse calorimetry has been applied for measuring heat capacity, specific electrical resistivity, and hemispherical total and normal spectral emissivity, and the laser flash method for measuring thermal diffusivity. Specific heat capacity and specific electrical resistivity were measured from 250 to 1 700 K, thermal diffusivity from 190 to 1 530 K, hemispherical total emissivity from 780 to 1 670 K, and normal spectral emissivity at 900 nm from 1 300 to 1 730 K. Thermal conductivity and Lorentz function were computed from experimental data in the range from about 190 to 1 530 K. For necessary corrections literature data on thermal linear expansion were used. The results obtained are compared with available literature values.
T2  - International Journal of Materials Research
T1  - Thermophysical properties of solid phase Ti-6Al-4V alloy over a wide temperature range
VL  - 103
IS  - 6
SP  - 707
EP  - 714
DO  - 10.3139/146.110678
ER  - 

@article{
author = "Milošević, Nenad D. and Aleksić, Ivana",
year = "2012",
abstract = "This paper presents experimental results on thermophysical properties of the most commonly used titanium alloy, Ti-6Al-4V, in its solid phase. The subsecond pulse calorimetry has been applied for measuring heat capacity, specific electrical resistivity, and hemispherical total and normal spectral emissivity, and the laser flash method for measuring thermal diffusivity. Specific heat capacity and specific electrical resistivity were measured from 250 to 1 700 K, thermal diffusivity from 190 to 1 530 K, hemispherical total emissivity from 780 to 1 670 K, and normal spectral emissivity at 900 nm from 1 300 to 1 730 K. Thermal conductivity and Lorentz function were computed from experimental data in the range from about 190 to 1 530 K. For necessary corrections literature data on thermal linear expansion were used. The results obtained are compared with available literature values.",
journal = "International Journal of Materials Research",
title = "Thermophysical properties of solid phase Ti-6Al-4V alloy over a wide temperature range",
volume = "103",
number = "6",
pages = "707-714",
doi = "10.3139/146.110678"
}

Milošević, N. D.,& Aleksić, I.. (2012). Thermophysical properties of solid phase Ti-6Al-4V alloy over a wide temperature range. in International Journal of Materials Research, 103(6), 707-714.
https://doi.org/10.3139/146.110678

Milošević ND, Aleksić I. Thermophysical properties of solid phase Ti-6Al-4V alloy over a wide temperature range. in International Journal of Materials Research. 2012;103(6):707-714.
doi:10.3139/146.110678 .

Milošević, Nenad D., Aleksić, Ivana, "Thermophysical properties of solid phase Ti-6Al-4V alloy over a wide temperature range" in International Journal of Materials Research, 103, no. 6 (2012):707-714,
https://doi.org/10.3139/146.110678 . .