TY  - JOUR
AU  - Rakašević, Dragana
AU  - Marinković, Jelena
AU  - Rakonjac, Bojan
AU  - Arce, Marion
AU  - Joksimović, Ena
AU  - Marković, Jovana
AU  - Kulić, Milan
AU  - Hadži-Mihailović, Miloš
AU  - Marković, Aleksa
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12444
AB  - Background: The long-term use of antifungal therapy in denture stomatitis (DS) treatment could be accompanied by antifungal-resistant strain onset, leading to compromised therapeutic procedure and disease reappearance. Photodynamic therapy (PDT) has shown the ability to eradicate oral infections and resistance strains. This prospective clinical study aimed to assess the PDT’s effectiveness compared to the conventional treatment on clinical and microbiological parameters in patients with DS without denture wear during the treatment and follow-ups. Methods: Forty-two patients diagnosed with DS were randomly assigned to one-session single PDT application (test group) or conventional antifungal therapy (control group). Clinical and microbiological parameters were assessed and analyzed before and at 3rd, 15th, and 30th day following the treatments. Microbiological samples were analyzed by a Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The data was statistically analyzed. Results: Prior to the treatment, Candida species, including C. albicans (100%), C. glabrata (33%), C. tropicalis (31%), C. krusei (31%) were isolated in all patients. Both treatment procedures demonstrated a statistically significant reduction in C. albicans at all follow-up time intervals (p < 0.05). However, PDT displayed a statistically significant reduction in C. krusei compared to the conventional treatment at all follow-up periods (p < 0.05). Clinical parameters improved considerably in the test group compared to the control group at the 3rd and 15th day of follow-up. Conclusion: One-session single PDT application demonstrated significant improvement in both clinical and microbiological outcomes in a short-term period, resulting in complete Candida spp. eradication compared to conventional antifungal therapy.
T2  - Photodiagnosis and Photodynamic Therapy
T1  - Evaluation of photodynamic therapy efficacy vs. conventional antifungal therapy in patients with poor-fitting dentures suffering from denture stomatitis. A prospective clinical study
VL  - 45
SP  - 103913
DO  - 10.1016/j.pdpdt.2023.103913
ER  - 

@article{
author = "Rakašević, Dragana and Marinković, Jelena and Rakonjac, Bojan and Arce, Marion and Joksimović, Ena and Marković, Jovana and Kulić, Milan and Hadži-Mihailović, Miloš and Marković, Aleksa",
year = "2024",
abstract = "Background: The long-term use of antifungal therapy in denture stomatitis (DS) treatment could be accompanied by antifungal-resistant strain onset, leading to compromised therapeutic procedure and disease reappearance. Photodynamic therapy (PDT) has shown the ability to eradicate oral infections and resistance strains. This prospective clinical study aimed to assess the PDT’s effectiveness compared to the conventional treatment on clinical and microbiological parameters in patients with DS without denture wear during the treatment and follow-ups. Methods: Forty-two patients diagnosed with DS were randomly assigned to one-session single PDT application (test group) or conventional antifungal therapy (control group). Clinical and microbiological parameters were assessed and analyzed before and at 3rd, 15th, and 30th day following the treatments. Microbiological samples were analyzed by a Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The data was statistically analyzed. Results: Prior to the treatment, Candida species, including C. albicans (100%), C. glabrata (33%), C. tropicalis (31%), C. krusei (31%) were isolated in all patients. Both treatment procedures demonstrated a statistically significant reduction in C. albicans at all follow-up time intervals (p < 0.05). However, PDT displayed a statistically significant reduction in C. krusei compared to the conventional treatment at all follow-up periods (p < 0.05). Clinical parameters improved considerably in the test group compared to the control group at the 3rd and 15th day of follow-up. Conclusion: One-session single PDT application demonstrated significant improvement in both clinical and microbiological outcomes in a short-term period, resulting in complete Candida spp. eradication compared to conventional antifungal therapy.",
journal = "Photodiagnosis and Photodynamic Therapy",
title = "Evaluation of photodynamic therapy efficacy vs. conventional antifungal therapy in patients with poor-fitting dentures suffering from denture stomatitis. A prospective clinical study",
volume = "45",
pages = "103913",
doi = "10.1016/j.pdpdt.2023.103913"
}

Rakašević, D., Marinković, J., Rakonjac, B., Arce, M., Joksimović, E., Marković, J., Kulić, M., Hadži-Mihailović, M.,& Marković, A.. (2024). Evaluation of photodynamic therapy efficacy vs. conventional antifungal therapy in patients with poor-fitting dentures suffering from denture stomatitis. A prospective clinical study. in Photodiagnosis and Photodynamic Therapy, 45, 103913.
https://doi.org/10.1016/j.pdpdt.2023.103913

Rakašević D, Marinković J, Rakonjac B, Arce M, Joksimović E, Marković J, Kulić M, Hadži-Mihailović M, Marković A. Evaluation of photodynamic therapy efficacy vs. conventional antifungal therapy in patients with poor-fitting dentures suffering from denture stomatitis. A prospective clinical study. in Photodiagnosis and Photodynamic Therapy. 2024;45:103913.
doi:10.1016/j.pdpdt.2023.103913 .

Rakašević, Dragana, Marinković, Jelena, Rakonjac, Bojan, Arce, Marion, Joksimović, Ena, Marković, Jovana, Kulić, Milan, Hadži-Mihailović, Miloš, Marković, Aleksa, "Evaluation of photodynamic therapy efficacy vs. conventional antifungal therapy in patients with poor-fitting dentures suffering from denture stomatitis. A prospective clinical study" in Photodiagnosis and Photodynamic Therapy, 45 (2024):103913,
https://doi.org/10.1016/j.pdpdt.2023.103913 . .

TY  - JOUR
AU  - Marinković, Jelena
AU  - Rakašević, Dragana
AU  - Nemoda, Milica
AU  - Nikolić, Biljana
AU  - Marković, Tatjana
AU  - Matijević, Stevo
AU  - Marković, Dejan
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11670
AB  - The possibility to utilize the antibacterial and antibiofilm potential of essential oils (EOs) in dentistry is recognized and best seen in the design of EO-based mouthwashes. The up-to-date results, obtained with the most commonly used formulation being consisted of thymol, eucalyptol, menthol, and methyl salicylate (Listerine), proved its efficacy against plaque and gingival inflammation. However, novel alcohol-free products remain to be further investigated. Commercially available mouthwash containing curcumin, clove oil, mentha oil, eucalyptol, thymol and tea tree oil, and the mouthwash based on ginger EO (a-zingiberene, b-bisabolene, b-sesquiphellandrene, curcumene), reduced plaque index and improved periodontal status of the patients. The plaque index was also reduced and overall healing was improved after the surgical removal of the third molar by mouthwash containing John wort oil. In addition, Cinnamomum zeylanicum EO-based mouthwash and mouthwash containing peppermint oil were efficient against stomatitis and xerostomia, respectively. In addition to beneficial effects achieved in the mouth, i.e. at the appropriate site of application, novel investigations pointed-out that EO-based mouthwashes could be recognized as efficient in the reduction of bacterial and viral aerosols. This has been shown for Listerine, and for several mouthwashes containing following active substances of plants' EO origin: a-farnesene, b-farnesene, farnesol, nerolidol, a-bulnesene, eremanthin, b-sesquiphellandrene, spiroether, cinnamylacetate, cinnamaldehyde, eugenol, menthol, and carvacrol. This finding could be of special interest, in order to be included in further clinical studies related to COVID -19 pandemic.
T2  - Balkan Journal of Dental Medicine
T1  - EO-based mouthwashes: Is there something that should be known?
VL  - 27
IS  - 1
SP  - 32
EP  - 37
DO  - 10.5937/bjdm2301032M
ER  - 

@article{
author = "Marinković, Jelena and Rakašević, Dragana and Nemoda, Milica and Nikolić, Biljana and Marković, Tatjana and Matijević, Stevo and Marković, Dejan",
year = "2023",
abstract = "The possibility to utilize the antibacterial and antibiofilm potential of essential oils (EOs) in dentistry is recognized and best seen in the design of EO-based mouthwashes. The up-to-date results, obtained with the most commonly used formulation being consisted of thymol, eucalyptol, menthol, and methyl salicylate (Listerine), proved its efficacy against plaque and gingival inflammation. However, novel alcohol-free products remain to be further investigated. Commercially available mouthwash containing curcumin, clove oil, mentha oil, eucalyptol, thymol and tea tree oil, and the mouthwash based on ginger EO (a-zingiberene, b-bisabolene, b-sesquiphellandrene, curcumene), reduced plaque index and improved periodontal status of the patients. The plaque index was also reduced and overall healing was improved after the surgical removal of the third molar by mouthwash containing John wort oil. In addition, Cinnamomum zeylanicum EO-based mouthwash and mouthwash containing peppermint oil were efficient against stomatitis and xerostomia, respectively. In addition to beneficial effects achieved in the mouth, i.e. at the appropriate site of application, novel investigations pointed-out that EO-based mouthwashes could be recognized as efficient in the reduction of bacterial and viral aerosols. This has been shown for Listerine, and for several mouthwashes containing following active substances of plants' EO origin: a-farnesene, b-farnesene, farnesol, nerolidol, a-bulnesene, eremanthin, b-sesquiphellandrene, spiroether, cinnamylacetate, cinnamaldehyde, eugenol, menthol, and carvacrol. This finding could be of special interest, in order to be included in further clinical studies related to COVID -19 pandemic.",
journal = "Balkan Journal of Dental Medicine",
title = "EO-based mouthwashes: Is there something that should be known?",
volume = "27",
number = "1",
pages = "32-37",
doi = "10.5937/bjdm2301032M"
}

Marinković, J., Rakašević, D., Nemoda, M., Nikolić, B., Marković, T., Matijević, S.,& Marković, D.. (2023). EO-based mouthwashes: Is there something that should be known?. in Balkan Journal of Dental Medicine, 27(1), 32-37.
https://doi.org/10.5937/bjdm2301032M

Marinković J, Rakašević D, Nemoda M, Nikolić B, Marković T, Matijević S, Marković D. EO-based mouthwashes: Is there something that should be known?. in Balkan Journal of Dental Medicine. 2023;27(1):32-37.
doi:10.5937/bjdm2301032M .

Marinković, Jelena, Rakašević, Dragana, Nemoda, Milica, Nikolić, Biljana, Marković, Tatjana, Matijević, Stevo, Marković, Dejan, "EO-based mouthwashes: Is there something that should be known?" in Balkan Journal of Dental Medicine, 27, no. 1 (2023):32-37,
https://doi.org/10.5937/bjdm2301032M . .

TY  - JOUR
AU  - Rakašević, Dragana
AU  - Marinković, Jelena
AU  - Marković, Jovan
AU  - Nikolić, Biljana
AU  - Marković, Dejan
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11673
AB  - Background  The study aimed at determining antibacterial efficiency of adjuvant photodynamic therapy (PDT) and high-power diode laser (DL) in the treatment of chronic periapical periodontitis (CPP) in young permanent teeth. Methods  Forty-four young permanent teeth with CPP were randomly divided into three groups (PDT, DL and control). Each tooth underwent standard chemo-mechanical treatment, while within tested groups was additionally treated by PDT or DL. Bacterial identification and quantification were provided by MALDI–TOF spectrometry and plate counting assay, performed after accessing the canal, following chemo-mechanical preparation, and after PDT or DL procedure where applicable. Results  Thirty-nine young permanent teeth with CCP (patients age 9.77 ± 1.43) completed the study. Before the treatments, 202 isolates belonging to 13 genera/species, including Streptococcus (36), Actinomyces (34), Peptostreptococcus micros (27), Veillonella (25) and Enterococcus faecalis (22), were recovered. Chemo-mechanical treatment reduced CFU count in the all three groups (p < 0.001), but complete eradication was not observed for any of isolated species. Adjuvant PDT and DL completely eradicated isolates of 8 and 6 bacterial genera/species, resulting in complete bacterial elimination from 53.8% and 30.8% of root canals, respectively. In the rest canals, total Δlog CFUs were 4.71 and 4.58. Conclusion  The results indicated that both PDT and DL could be performed as adjuvants to standard endodontic treatment of the young permanent teeth with CPP.
T2  - Photodiagnosis and Photodynamic Therapy
T1  - Antibacterial efficiency of adjuvant photodynamic therapy and high-power diode laser in the treatment of young permanent teeth with chronic periapical periodontitis. A prospective clinical study
VL  - 41
SP  - 103129
DO  - 10.1016/j.pdpdt.2022.103129
ER  - 

@article{
author = "Rakašević, Dragana and Marinković, Jelena and Marković, Jovan and Nikolić, Biljana and Marković, Dejan",
year = "2023",
abstract = "Background  The study aimed at determining antibacterial efficiency of adjuvant photodynamic therapy (PDT) and high-power diode laser (DL) in the treatment of chronic periapical periodontitis (CPP) in young permanent teeth. Methods  Forty-four young permanent teeth with CPP were randomly divided into three groups (PDT, DL and control). Each tooth underwent standard chemo-mechanical treatment, while within tested groups was additionally treated by PDT or DL. Bacterial identification and quantification were provided by MALDI–TOF spectrometry and plate counting assay, performed after accessing the canal, following chemo-mechanical preparation, and after PDT or DL procedure where applicable. Results  Thirty-nine young permanent teeth with CCP (patients age 9.77 ± 1.43) completed the study. Before the treatments, 202 isolates belonging to 13 genera/species, including Streptococcus (36), Actinomyces (34), Peptostreptococcus micros (27), Veillonella (25) and Enterococcus faecalis (22), were recovered. Chemo-mechanical treatment reduced CFU count in the all three groups (p < 0.001), but complete eradication was not observed for any of isolated species. Adjuvant PDT and DL completely eradicated isolates of 8 and 6 bacterial genera/species, resulting in complete bacterial elimination from 53.8% and 30.8% of root canals, respectively. In the rest canals, total Δlog CFUs were 4.71 and 4.58. Conclusion  The results indicated that both PDT and DL could be performed as adjuvants to standard endodontic treatment of the young permanent teeth with CPP.",
journal = "Photodiagnosis and Photodynamic Therapy",
title = "Antibacterial efficiency of adjuvant photodynamic therapy and high-power diode laser in the treatment of young permanent teeth with chronic periapical periodontitis. A prospective clinical study",
volume = "41",
pages = "103129",
doi = "10.1016/j.pdpdt.2022.103129"
}

Rakašević, D., Marinković, J., Marković, J., Nikolić, B.,& Marković, D.. (2023). Antibacterial efficiency of adjuvant photodynamic therapy and high-power diode laser in the treatment of young permanent teeth with chronic periapical periodontitis. A prospective clinical study. in Photodiagnosis and Photodynamic Therapy, 41, 103129.
https://doi.org/10.1016/j.pdpdt.2022.103129

Rakašević D, Marinković J, Marković J, Nikolić B, Marković D. Antibacterial efficiency of adjuvant photodynamic therapy and high-power diode laser in the treatment of young permanent teeth with chronic periapical periodontitis. A prospective clinical study. in Photodiagnosis and Photodynamic Therapy. 2023;41:103129.
doi:10.1016/j.pdpdt.2022.103129 .

Rakašević, Dragana, Marinković, Jelena, Marković, Jovan, Nikolić, Biljana, Marković, Dejan, "Antibacterial efficiency of adjuvant photodynamic therapy and high-power diode laser in the treatment of young permanent teeth with chronic periapical periodontitis. A prospective clinical study" in Photodiagnosis and Photodynamic Therapy, 41 (2023):103129,
https://doi.org/10.1016/j.pdpdt.2022.103129 . .