Savić, Jasmina

Link to this page

Authority KeyName Variants
orcid::0000-0003-1094-7292
  • Savić, Jasmina (40)
Projects
Studies of enzyme interactions with toxic and pharmacologically active molecules Istraživanje mehanizma interakcija biološki aktivnih jedinjenja sa biomolekulima
[1991] An integral study to identify the regional genetic and environmental risk factors for the common noncommunicable diseases in the human population of Serbia - INGEMA_S
Fluidized bed combustion facility improvements as a step forward in developing energy efficient and environmentally sound waste combustion technology in fluidized bed combustors [2700PL309/2003]
AIRC [IG-12085], Beneficentia Stiftung Vaduz Australian Research Council [DP120100126]
CNCSIS [69/2006] CNCSIS [ET 3264/2005], Ministry of Science and Environmental Protection of Serbia [142051b]
Development of sensor-based Citizens' Observatory Community for improving quality of life in cities Size-, shape- and structure- dependent properties of nanoparticles and nanocomposites
Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200017 (University of Belgrade, Institute of Nuclear Sciences 'Vinča', Belgrade-Vinča) Cellular and molecular basis of neuroinflamation: potential targets for translational medicine and therapy
Evaluation of energy performances and indoor environment quality of educational buildings in Serbia with impact to health Magnetic and radionuclide labeled nanostructured materials for medical applications
Ministry of Education, Science and Technological Development of the Republic of Serbia Ministry of Science and Technological Development of the Republic of Serbia
Ministry of Science and Technological Development of the Republic of Serbia [14051b], The German Research Council (Deutsche Forschungsgerneinschaft) [DFG Schi 476/5-1, Schi 476/7-1], The Federal Ministry of Education and Research [BMBF 0313836] Ministry of Science and Technological Development of the Republic of Serbia [142051], Ministry of Higher Education, Science and Technology of the Republic of Slovenia
Serbian Ministry of Science and technology [E143005]

Author's Bibliography

Yellow gentian root extract provokes concentration- and time-dependent response in peripheral blood mononuclear cells

Valenta-Šobot, Ana; Drakulić, Dunja R.; Joksić, Gordana; Miletić Vukajlović, Jadranka; Savić, Jasmina; Potočnik, Jelena; Filipović Tričković, Jelena G.

(2020)

TY  - JOUR
AU  - Valenta-Šobot, Ana
AU  - Drakulić, Dunja R.
AU  - Joksić, Gordana
AU  - Miletić Vukajlović, Jadranka
AU  - Savić, Jasmina
AU  - Potočnik, Jelena
AU  - Filipović Tričković, Jelena G.
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9523
AB  - Yellow gentian (Gentiana lutea L.), a medicinal plant widely used in traditional medicine, displays multiple biological effects, ranging from beneficial to toxic. Since many promising applications have been reported so far, our aim was to evaluate its potential concentration- and time- dependent cytotoxic and genotoxic effects in vitro . To that end we exposed human peripheral blood mononuclear cells to 0.5, 1, and 2 mg/mL of yellow gentian root extract (YGRE) to determine its effects on oxidative stress parameters [pro/antioxidant balance (PAB) and lipid peroxidation], DNA damage (alkaline comet assay and chromosome aberrations), and cell viability (trypan blue exclusion test). Cell viability decreased with increasing concentrations and treatment duration. Only the lowest YGRE concentration (0.5 mg/mL) increased oxidative stress but produced minor DNA damage and cytotoxicity. At higher concentrations, redox parameters returned to near control values. The percentage of chromosome aberrations and percentage of DNA in the comet tail increased with increased YGRE concentration after 48 h and declined after 72 h of treatment. This points to the activation of DNA repair mechanism (homologous recombination), evidenced by the formation of chromosomal radial figures after 72 h of treatment with the highest YGRE concentration of 2 mg/mL. Our results suggest that YGRE, despite induction of cytotoxic and genotoxic effects, activates cell repair mechanisms that counter oxidative and DNA lesions and induce cell death in highly damaged cells. Therefore, observed protective effects of yellow gentian after longer exposure could be a result of activated repair and removal of cells with irreparable damage.
T2  - Archives of Industrial Hygiene and Toxicology
T1  - Yellow gentian root extract provokes concentration- and time-dependent response in peripheral blood mononuclear cells
VL  - 71
IS  - 4
SP  - 320
EP  - 328
DO  - 10.2478/aiht-2020-71-3476
ER  - 
@article{
author = "Valenta-Šobot, Ana and Drakulić, Dunja R. and Joksić, Gordana and Miletić Vukajlović, Jadranka and Savić, Jasmina and Potočnik, Jelena and Filipović Tričković, Jelena G.",
year = "2020",
abstract = "Yellow gentian (Gentiana lutea L.), a medicinal plant widely used in traditional medicine, displays multiple biological effects, ranging from beneficial to toxic. Since many promising applications have been reported so far, our aim was to evaluate its potential concentration- and time- dependent cytotoxic and genotoxic effects in vitro . To that end we exposed human peripheral blood mononuclear cells to 0.5, 1, and 2 mg/mL of yellow gentian root extract (YGRE) to determine its effects on oxidative stress parameters [pro/antioxidant balance (PAB) and lipid peroxidation], DNA damage (alkaline comet assay and chromosome aberrations), and cell viability (trypan blue exclusion test). Cell viability decreased with increasing concentrations and treatment duration. Only the lowest YGRE concentration (0.5 mg/mL) increased oxidative stress but produced minor DNA damage and cytotoxicity. At higher concentrations, redox parameters returned to near control values. The percentage of chromosome aberrations and percentage of DNA in the comet tail increased with increased YGRE concentration after 48 h and declined after 72 h of treatment. This points to the activation of DNA repair mechanism (homologous recombination), evidenced by the formation of chromosomal radial figures after 72 h of treatment with the highest YGRE concentration of 2 mg/mL. Our results suggest that YGRE, despite induction of cytotoxic and genotoxic effects, activates cell repair mechanisms that counter oxidative and DNA lesions and induce cell death in highly damaged cells. Therefore, observed protective effects of yellow gentian after longer exposure could be a result of activated repair and removal of cells with irreparable damage.",
journal = "Archives of Industrial Hygiene and Toxicology",
title = "Yellow gentian root extract provokes concentration- and time-dependent response in peripheral blood mononuclear cells",
volume = "71",
number = "4",
pages = "320-328",
doi = "10.2478/aiht-2020-71-3476"
}
Valenta-Šobot, A., Drakulić, D. R., Joksić, G., Miletić Vukajlović, J., Savić, J., Potočnik, J.,& Filipović Tričković, J. G.. (2020). Yellow gentian root extract provokes concentration- and time-dependent response in peripheral blood mononuclear cells. in Archives of Industrial Hygiene and Toxicology, 71(4), 320-328.
https://doi.org/10.2478/aiht-2020-71-3476
Valenta-Šobot A, Drakulić DR, Joksić G, Miletić Vukajlović J, Savić J, Potočnik J, Filipović Tričković JG. Yellow gentian root extract provokes concentration- and time-dependent response in peripheral blood mononuclear cells. in Archives of Industrial Hygiene and Toxicology. 2020;71(4):320-328.
doi:10.2478/aiht-2020-71-3476 .
Valenta-Šobot, Ana, Drakulić, Dunja R., Joksić, Gordana, Miletić Vukajlović, Jadranka, Savić, Jasmina, Potočnik, Jelena, Filipović Tričković, Jelena G., "Yellow gentian root extract provokes concentration- and time-dependent response in peripheral blood mononuclear cells" in Archives of Industrial Hygiene and Toxicology, 71, no. 4 (2020):320-328,
https://doi.org/10.2478/aiht-2020-71-3476 . .

Distribution of PAHs in coal ashes from the thermal power plant and fluidized bed combustion system; estimation of environmental risk of ash disposal

Buha Marković, Jovana; Marinković, Ana D.; Nemoda, Stevan; Savić, Jasmina

(2020)

TY  - JOUR
AU  - Buha Marković, Jovana
AU  - Marinković, Ana D.
AU  - Nemoda, Stevan
AU  - Savić, Jasmina
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9124
AB  - The comparison of fly ash generated from lignite combustion in a thermal power plant Kolubara A (Veliki Crljeni) and bottom and fly ash from coal waste combustion in a semi-industrial fluidized bed boiler (Vinča) was performed as the function of particle size. The average total concentrations of the 16 EPA priority PAHs in ash fractions are 0.49 mg kg−1 of ash (thermal power plant) and 17.48 mg kg−1 of ash (fluidized bed boiler). The sum of 3- and 4-ring PAHs accounts for more than 93% of overall PAHs concentration, and the most abundant among them is fluoranthene. The portions of PAHs groups defined based on their physico-chemical properties, as obtained from quantitative structure-activity relationship (QSAR) models included in the Vega platform, were determined. These portions, emission factors, and benzo[a]pyrene equivalence concentrations were further on used to estimate the potential environmental impact of ash disposal. The PAHs emission factors are higher compared to values in the air pollutant emission inventory guidebook of the cooperative program for monitoring and evaluation of the long-range transmission of air pollutants in Europe (EMEP/EEA). The overall emission factors of 16 PAHs for combustion of lignite and coal waste are determined to be 0.15 and 249.97 mg kg−1 of fuel, respectively. Based on the ratios of benzo[a]pyrene equivalence concentrations of each ash and correspondent fuel, the disposal of fly ash from the cyclone of fluidized bed boiler represents the highest risk to the environment among tested ashes.
T2  - Environmental Pollution
T1  - Distribution of PAHs in coal ashes from the thermal power plant and fluidized bed combustion system; estimation of environmental risk of ash disposal
VL  - 266
SP  - 115282
DO  - 10.1016/j.envpol.2020.115282
ER  - 
@article{
author = "Buha Marković, Jovana and Marinković, Ana D. and Nemoda, Stevan and Savić, Jasmina",
year = "2020",
abstract = "The comparison of fly ash generated from lignite combustion in a thermal power plant Kolubara A (Veliki Crljeni) and bottom and fly ash from coal waste combustion in a semi-industrial fluidized bed boiler (Vinča) was performed as the function of particle size. The average total concentrations of the 16 EPA priority PAHs in ash fractions are 0.49 mg kg−1 of ash (thermal power plant) and 17.48 mg kg−1 of ash (fluidized bed boiler). The sum of 3- and 4-ring PAHs accounts for more than 93% of overall PAHs concentration, and the most abundant among them is fluoranthene. The portions of PAHs groups defined based on their physico-chemical properties, as obtained from quantitative structure-activity relationship (QSAR) models included in the Vega platform, were determined. These portions, emission factors, and benzo[a]pyrene equivalence concentrations were further on used to estimate the potential environmental impact of ash disposal. The PAHs emission factors are higher compared to values in the air pollutant emission inventory guidebook of the cooperative program for monitoring and evaluation of the long-range transmission of air pollutants in Europe (EMEP/EEA). The overall emission factors of 16 PAHs for combustion of lignite and coal waste are determined to be 0.15 and 249.97 mg kg−1 of fuel, respectively. Based on the ratios of benzo[a]pyrene equivalence concentrations of each ash and correspondent fuel, the disposal of fly ash from the cyclone of fluidized bed boiler represents the highest risk to the environment among tested ashes.",
journal = "Environmental Pollution",
title = "Distribution of PAHs in coal ashes from the thermal power plant and fluidized bed combustion system; estimation of environmental risk of ash disposal",
volume = "266",
pages = "115282",
doi = "10.1016/j.envpol.2020.115282"
}
Buha Marković, J., Marinković, A. D., Nemoda, S.,& Savić, J.. (2020). Distribution of PAHs in coal ashes from the thermal power plant and fluidized bed combustion system; estimation of environmental risk of ash disposal. in Environmental Pollution, 266, 115282.
https://doi.org/10.1016/j.envpol.2020.115282
Buha Marković J, Marinković AD, Nemoda S, Savić J. Distribution of PAHs in coal ashes from the thermal power plant and fluidized bed combustion system; estimation of environmental risk of ash disposal. in Environmental Pollution. 2020;266:115282.
doi:10.1016/j.envpol.2020.115282 .
Buha Marković, Jovana, Marinković, Ana D., Nemoda, Stevan, Savić, Jasmina, "Distribution of PAHs in coal ashes from the thermal power plant and fluidized bed combustion system; estimation of environmental risk of ash disposal" in Environmental Pollution, 266 (2020):115282,
https://doi.org/10.1016/j.envpol.2020.115282 . .
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3

Comparison of fine particulate matter level, chemical content and oxidative potential derived from two dissimilar urban environments

Jovanović, Maja; Savić, Jasmina; Kovačević, Renata; Tasić, Viša; Todorović, Žaklina; Stevanović, Svetlana; Manojlović, Dragan D.; Jovašević-Stojanović, Milena

(2020)

TY  - JOUR
AU  - Jovanović, Maja
AU  - Savić, Jasmina
AU  - Kovačević, Renata
AU  - Tasić, Viša
AU  - Todorović, Žaklina
AU  - Stevanović, Svetlana
AU  - Manojlović, Dragan D.
AU  - Jovašević-Stojanović, Milena
PY  - 2020
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3820
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/8750
AB  - Urban airborne particles contain a wide spectrum of components, known to have harmful effects on human health. This study reports a detailed investigation of fine particulate matter (PM2.5), chemical content and oxidative potential derived from two different urban environments. During summer and winter, 20-day campaigns were conducted at Belgrade city center (urban-background site – UB) and Bor (urban-industrial site – UI). Using various analytical techniques, carbonaceous compounds, water-soluble inorganic ions, major and trace elements were determined, while the oxidative potential of PM2.5 was estimated by dichloro-dihydro-fluorescein diacetate (DCFH-DA) assay (OPDCFH values). The mean PM2.5 concentrations in both urban environments were above the recommended daily value, and the dominant PM2.5 mass contributor was organic matter (29–55%). The OC/EC ratio was significantly higher at UB site during winter, which was an indication of a considerable contribution of secondary organic carbon to the overall organic carbon (OC). Water-soluble organic carbon (WSOC) was also higher at UB than at UI site, and it probably came from the same sources as OC. In general, the different partition of secondary organic aerosol (SOA) in warm and cold periods affected the number of organic components. Sulfates and nitrates were the most abundant ions at both sites and they counted approximately 40% (summer) and 50% (winter) of total ions. Further, the concentrations of the most elements, particularly some potentially carcinogenic elements such as As, Cd and Pb were significantly higher at UI, due to the emissions from the copper smelter complex in the vicinity. The mean OPDCFH values were similar during the summer at both sampling sites, whereas a statistically significant difference between sites was noticed in favor of UB environment in winter.
T2  - Science of the Total Environment
T1  - Comparison of fine particulate matter level, chemical content and oxidative potential derived from two dissimilar urban environments
VL  - 708
SP  - 135209
DO  - 10.1016/j.scitotenv.2019.135209
ER  - 
@article{
author = "Jovanović, Maja and Savić, Jasmina and Kovačević, Renata and Tasić, Viša and Todorović, Žaklina and Stevanović, Svetlana and Manojlović, Dragan D. and Jovašević-Stojanović, Milena",
year = "2020",
abstract = "Urban airborne particles contain a wide spectrum of components, known to have harmful effects on human health. This study reports a detailed investigation of fine particulate matter (PM2.5), chemical content and oxidative potential derived from two different urban environments. During summer and winter, 20-day campaigns were conducted at Belgrade city center (urban-background site – UB) and Bor (urban-industrial site – UI). Using various analytical techniques, carbonaceous compounds, water-soluble inorganic ions, major and trace elements were determined, while the oxidative potential of PM2.5 was estimated by dichloro-dihydro-fluorescein diacetate (DCFH-DA) assay (OPDCFH values). The mean PM2.5 concentrations in both urban environments were above the recommended daily value, and the dominant PM2.5 mass contributor was organic matter (29–55%). The OC/EC ratio was significantly higher at UB site during winter, which was an indication of a considerable contribution of secondary organic carbon to the overall organic carbon (OC). Water-soluble organic carbon (WSOC) was also higher at UB than at UI site, and it probably came from the same sources as OC. In general, the different partition of secondary organic aerosol (SOA) in warm and cold periods affected the number of organic components. Sulfates and nitrates were the most abundant ions at both sites and they counted approximately 40% (summer) and 50% (winter) of total ions. Further, the concentrations of the most elements, particularly some potentially carcinogenic elements such as As, Cd and Pb were significantly higher at UI, due to the emissions from the copper smelter complex in the vicinity. The mean OPDCFH values were similar during the summer at both sampling sites, whereas a statistically significant difference between sites was noticed in favor of UB environment in winter.",
journal = "Science of the Total Environment",
title = "Comparison of fine particulate matter level, chemical content and oxidative potential derived from two dissimilar urban environments",
volume = "708",
pages = "135209",
doi = "10.1016/j.scitotenv.2019.135209"
}
Jovanović, M., Savić, J., Kovačević, R., Tasić, V., Todorović, Ž., Stevanović, S., Manojlović, D. D.,& Jovašević-Stojanović, M.. (2020). Comparison of fine particulate matter level, chemical content and oxidative potential derived from two dissimilar urban environments. in Science of the Total Environment, 708, 135209.
https://doi.org/10.1016/j.scitotenv.2019.135209
Jovanović M, Savić J, Kovačević R, Tasić V, Todorović Ž, Stevanović S, Manojlović DD, Jovašević-Stojanović M. Comparison of fine particulate matter level, chemical content and oxidative potential derived from two dissimilar urban environments. in Science of the Total Environment. 2020;708:135209.
doi:10.1016/j.scitotenv.2019.135209 .
Jovanović, Maja, Savić, Jasmina, Kovačević, Renata, Tasić, Viša, Todorović, Žaklina, Stevanović, Svetlana, Manojlović, Dragan D., Jovašević-Stojanović, Milena, "Comparison of fine particulate matter level, chemical content and oxidative potential derived from two dissimilar urban environments" in Science of the Total Environment, 708 (2020):135209,
https://doi.org/10.1016/j.scitotenv.2019.135209 . .
1
1
1

UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations

Savić, Jasmina; Petrović, Sandra; Leskovac, Andreja; Lazarević-Pašti, Tamara; Nastasijević, Branislav J.; Tanović, Brankica B.; Gašić, Slavica M.; Vasić, Vesna M.

(2019)

TY  - JOUR
AU  - Savić, Jasmina
AU  - Petrović, Sandra
AU  - Leskovac, Andreja
AU  - Lazarević-Pašti, Tamara
AU  - Nastasijević, Branislav J.
AU  - Tanović, Brankica B.
AU  - Gašić, Slavica M.
AU  - Vasić, Vesna M.
PY  - 2019
UR  - https://linkinghub.elsevier.com/retrieve/pii/S0308814618313670
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/7821
AB  - UV-C irradiation is widely used in the food industry. However, the health effects from dietary exposure to the irradiated pesticide residues retained in foodstuffs are underestimated. In this study, technical chlorpyrifos (TCPF) and its oil in water (EW) and emulsifiable concentrate (EC) formulations were irradiated by UV-C, and their photodegradation products were subjected to toxicity assessment, including determination of acetylcholinesterase (AChE) activity, genotoxicity and oxidative stress using human blood cells as a model system. Toxicity studies were performed using the chlorpyrifos concentrations in the range of those proposed as the maximum residue levels in plant commodities. TCPF, EW and EC photodegradation products induced DNA damage and oxidative stress, and their genotoxicity did not decrease as a function of irradiation time. Irradiated TCPF and EC are more potent AChE inhibitors than irradiated EW. Accordingly, the application of UV-C irradiation must be considered when processing the plants previously treated with chlorpyrifos formulations. © 2018 Elsevier Ltd
T2  - Food Chemistry
T1  - UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations
VL  - 271
SP  - 469
EP  - 478
DO  - 10.1016/j.foodchem.2018.07.207
ER  - 
@article{
author = "Savić, Jasmina and Petrović, Sandra and Leskovac, Andreja and Lazarević-Pašti, Tamara and Nastasijević, Branislav J. and Tanović, Brankica B. and Gašić, Slavica M. and Vasić, Vesna M.",
year = "2019",
abstract = "UV-C irradiation is widely used in the food industry. However, the health effects from dietary exposure to the irradiated pesticide residues retained in foodstuffs are underestimated. In this study, technical chlorpyrifos (TCPF) and its oil in water (EW) and emulsifiable concentrate (EC) formulations were irradiated by UV-C, and their photodegradation products were subjected to toxicity assessment, including determination of acetylcholinesterase (AChE) activity, genotoxicity and oxidative stress using human blood cells as a model system. Toxicity studies were performed using the chlorpyrifos concentrations in the range of those proposed as the maximum residue levels in plant commodities. TCPF, EW and EC photodegradation products induced DNA damage and oxidative stress, and their genotoxicity did not decrease as a function of irradiation time. Irradiated TCPF and EC are more potent AChE inhibitors than irradiated EW. Accordingly, the application of UV-C irradiation must be considered when processing the plants previously treated with chlorpyrifos formulations. © 2018 Elsevier Ltd",
journal = "Food Chemistry",
title = "UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations",
volume = "271",
pages = "469-478",
doi = "10.1016/j.foodchem.2018.07.207"
}
Savić, J., Petrović, S., Leskovac, A., Lazarević-Pašti, T., Nastasijević, B. J., Tanović, B. B., Gašić, S. M.,& Vasić, V. M.. (2019). UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations. in Food Chemistry, 271, 469-478.
https://doi.org/10.1016/j.foodchem.2018.07.207
Savić J, Petrović S, Leskovac A, Lazarević-Pašti T, Nastasijević BJ, Tanović BB, Gašić SM, Vasić VM. UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations. in Food Chemistry. 2019;271:469-478.
doi:10.1016/j.foodchem.2018.07.207 .
Savić, Jasmina, Petrović, Sandra, Leskovac, Andreja, Lazarević-Pašti, Tamara, Nastasijević, Branislav J., Tanović, Brankica B., Gašić, Slavica M., Vasić, Vesna M., "UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations" in Food Chemistry, 271 (2019):469-478,
https://doi.org/10.1016/j.foodchem.2018.07.207 . .
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Supplementary data: UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations

Savić, Jasmina; Petrović, Sandra; Leskovac, Andreja; Lazarević-Pašti, Tamara; Nastasijević, Branislav J.; Tanović, Brankica B.; Gašić, Slavica M.; Vasić, Vesna M.

(2019)

TY  - GEN
AU  - Savić, Jasmina
AU  - Petrović, Sandra
AU  - Leskovac, Andreja
AU  - Lazarević-Pašti, Tamara
AU  - Nastasijević, Branislav J.
AU  - Tanović, Brankica B.
AU  - Gašić, Slavica M.
AU  - Vasić, Vesna M.
PY  - 2019
UR  - https://linkinghub.elsevier.com/retrieve/pii/S0308814618313670
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/7831
AB  - Supplementary data 1: Table 1S. The chromatographic gradient profile; Table 2S. CPF concentration decrease (corresponding initial CPF concentration decrease was set as 0%) for all three forms of CPF depending on irradiation time; Table 3S. CPF and CPO concentrations determined chromatographically for TCPF, EW and EC formulations, as the function of irradiation time; % of CPO comparing to initial CPF concentration in all three forms of CPF; 
Supplementary data 2: Material safety data sheet according to 1907/2006/EC, Article 31/version 1; 
Supplementary data 3: Material safety data sheet according to 1907/2006/EC, Article 31/version 4
T2  - Food Chemistry
T1  - Supplementary data: UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations
VL  - 271
SP  - 469
EP  - 478
DO  - 10.1016/j.foodchem.2018.07.207
ER  - 
@misc{
author = "Savić, Jasmina and Petrović, Sandra and Leskovac, Andreja and Lazarević-Pašti, Tamara and Nastasijević, Branislav J. and Tanović, Brankica B. and Gašić, Slavica M. and Vasić, Vesna M.",
year = "2019",
abstract = "Supplementary data 1: Table 1S. The chromatographic gradient profile; Table 2S. CPF concentration decrease (corresponding initial CPF concentration decrease was set as 0%) for all three forms of CPF depending on irradiation time; Table 3S. CPF and CPO concentrations determined chromatographically for TCPF, EW and EC formulations, as the function of irradiation time; % of CPO comparing to initial CPF concentration in all three forms of CPF; 
Supplementary data 2: Material safety data sheet according to 1907/2006/EC, Article 31/version 1; 
Supplementary data 3: Material safety data sheet according to 1907/2006/EC, Article 31/version 4",
journal = "Food Chemistry",
title = "Supplementary data: UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations",
volume = "271",
pages = "469-478",
doi = "10.1016/j.foodchem.2018.07.207"
}
Savić, J., Petrović, S., Leskovac, A., Lazarević-Pašti, T., Nastasijević, B. J., Tanović, B. B., Gašić, S. M.,& Vasić, V. M.. (2019). Supplementary data: UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations. in Food Chemistry, 271, 469-478.
https://doi.org/10.1016/j.foodchem.2018.07.207
Savić J, Petrović S, Leskovac A, Lazarević-Pašti T, Nastasijević BJ, Tanović BB, Gašić SM, Vasić VM. Supplementary data: UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations. in Food Chemistry. 2019;271:469-478.
doi:10.1016/j.foodchem.2018.07.207 .
Savić, Jasmina, Petrović, Sandra, Leskovac, Andreja, Lazarević-Pašti, Tamara, Nastasijević, Branislav J., Tanović, Brankica B., Gašić, Slavica M., Vasić, Vesna M., "Supplementary data: UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations" in Food Chemistry, 271 (2019):469-478,
https://doi.org/10.1016/j.foodchem.2018.07.207 . .
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8

Measurements of Oxidative Potential of Particulate Matter at Belgrade Tunnel; Comparison of BPEAnit, DTT and DCFH Assays

Jovanović, Maja; Savić, Jasmina; Salimi, Farhad; Stevanović, Svetlana; Brown, Reece A.; Jovašević-Stojanović, Milena; Manojlovic, Dragan; Bartonova, Alena; Bottle, Steven; Ristovski, Zoran

(2019)

TY  - JOUR
AU  - Jovanović, Maja
AU  - Savić, Jasmina
AU  - Salimi, Farhad
AU  - Stevanović, Svetlana
AU  - Brown, Reece A.
AU  - Jovašević-Stojanović, Milena
AU  - Manojlovic, Dragan
AU  - Bartonova, Alena
AU  - Bottle, Steven
AU  - Ristovski, Zoran
PY  - 2019
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/8677
AB  - To estimate the oxidative potential (OP) of particulate matter (PM), two commonly used cell-free, molecular probes were applied: dithiothreitol (DTT) and dichloro-dihydro-fluorescein diacetate (DCFH-DA), and their performance was compared with 9,10-bis (phenylethynyl) anthracene-nitroxide (BPEAnit). To the best of our knowledge, this is the first study in which the performance of the DTT and DCFH has been compared with the BPEAnit probe. The average concentrations of PM, organic carbon (OC) and elemental carbon (EC) for fine (PM2.5) and coarse (PM10) particles were determined. The results were 44.8 ± 13.7, 9.8 ± 5.1 and 9.3 ± 4.8 µg·m−3 for PM2.5 and 75.5 ± 25.1, 16.3 ± 8.7 and 11.8 ± 5.3 µg·m−3 for PM10, respectively, for PM, OC and EC. The water-soluble organic carbon (WSOC) fraction accounted for 42 ± 14% and 28 ± 9% of organic carbon in PM2.5 and PM10, respectively. The average volume normalized OP values for the three assays depended on both the sampling periods and the PM fractions. The OPBPEAnit had its peak at 2 p.m.; in the afternoon, it was three times higher compared to the morning and late afternoon values. The DCFH and BPEAnit results were correlated (r = 0.64), while there was no good agreement between the BPEAnit and the DTT (r = 0.14). The total organic content of PM does not necessarily represent oxidative capacity and it shows varying correlation with the OP. With respect to the two PM fractions studied, the OP was mostly associated with smaller particles.
T2  - International Journal of Environmental Research and Public Health
T1  - Measurements of Oxidative Potential of Particulate Matter at Belgrade Tunnel; Comparison of BPEAnit, DTT and DCFH Assays
VL  - 16
IS  - 24
SP  - 4906
DO  - 10.3390/ijerph16244906
ER  - 
@article{
author = "Jovanović, Maja and Savić, Jasmina and Salimi, Farhad and Stevanović, Svetlana and Brown, Reece A. and Jovašević-Stojanović, Milena and Manojlovic, Dragan and Bartonova, Alena and Bottle, Steven and Ristovski, Zoran",
year = "2019",
abstract = "To estimate the oxidative potential (OP) of particulate matter (PM), two commonly used cell-free, molecular probes were applied: dithiothreitol (DTT) and dichloro-dihydro-fluorescein diacetate (DCFH-DA), and their performance was compared with 9,10-bis (phenylethynyl) anthracene-nitroxide (BPEAnit). To the best of our knowledge, this is the first study in which the performance of the DTT and DCFH has been compared with the BPEAnit probe. The average concentrations of PM, organic carbon (OC) and elemental carbon (EC) for fine (PM2.5) and coarse (PM10) particles were determined. The results were 44.8 ± 13.7, 9.8 ± 5.1 and 9.3 ± 4.8 µg·m−3 for PM2.5 and 75.5 ± 25.1, 16.3 ± 8.7 and 11.8 ± 5.3 µg·m−3 for PM10, respectively, for PM, OC and EC. The water-soluble organic carbon (WSOC) fraction accounted for 42 ± 14% and 28 ± 9% of organic carbon in PM2.5 and PM10, respectively. The average volume normalized OP values for the three assays depended on both the sampling periods and the PM fractions. The OPBPEAnit had its peak at 2 p.m.; in the afternoon, it was three times higher compared to the morning and late afternoon values. The DCFH and BPEAnit results were correlated (r = 0.64), while there was no good agreement between the BPEAnit and the DTT (r = 0.14). The total organic content of PM does not necessarily represent oxidative capacity and it shows varying correlation with the OP. With respect to the two PM fractions studied, the OP was mostly associated with smaller particles.",
journal = "International Journal of Environmental Research and Public Health",
title = "Measurements of Oxidative Potential of Particulate Matter at Belgrade Tunnel; Comparison of BPEAnit, DTT and DCFH Assays",
volume = "16",
number = "24",
pages = "4906",
doi = "10.3390/ijerph16244906"
}
Jovanović, M., Savić, J., Salimi, F., Stevanović, S., Brown, R. A., Jovašević-Stojanović, M., Manojlovic, D., Bartonova, A., Bottle, S.,& Ristovski, Z.. (2019). Measurements of Oxidative Potential of Particulate Matter at Belgrade Tunnel; Comparison of BPEAnit, DTT and DCFH Assays. in International Journal of Environmental Research and Public Health, 16(24), 4906.
https://doi.org/10.3390/ijerph16244906
Jovanović M, Savić J, Salimi F, Stevanović S, Brown RA, Jovašević-Stojanović M, Manojlovic D, Bartonova A, Bottle S, Ristovski Z. Measurements of Oxidative Potential of Particulate Matter at Belgrade Tunnel; Comparison of BPEAnit, DTT and DCFH Assays. in International Journal of Environmental Research and Public Health. 2019;16(24):4906.
doi:10.3390/ijerph16244906 .
Jovanović, Maja, Savić, Jasmina, Salimi, Farhad, Stevanović, Svetlana, Brown, Reece A., Jovašević-Stojanović, Milena, Manojlovic, Dragan, Bartonova, Alena, Bottle, Steven, Ristovski, Zoran, "Measurements of Oxidative Potential of Particulate Matter at Belgrade Tunnel; Comparison of BPEAnit, DTT and DCFH Assays" in International Journal of Environmental Research and Public Health, 16, no. 24 (2019):4906,
https://doi.org/10.3390/ijerph16244906 . .
11
10
9

Structural, Optical, and Electrical Properties of Applied Amorphized and Polycrystalline Sb2S3 Thin Films

Janošević, Valentina; Mitrić, Miodrag; Savić, Jasmina; Validžić, Ivana Lj.

(Springer, 2016)

TY  - JOUR
AU  - Janošević, Valentina
AU  - Mitrić, Miodrag
AU  - Savić, Jasmina
AU  - Validžić, Ivana Lj.
PY  - 2016
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/957
AB  - One of the intermediate steps in the organo-colloidal synthesis of crystalline Sb2S3 is a synthesis of spherical amorphous Sb2S3. In order to prove that the synthesized semiconductor can be considered an absorbing material for a solar device, the electronic and photovoltage properties of the amorphized and polycrystalline Sb2S3 thin films deposited by synthesized amorphous nanoparticles were studied. Optical studies revealed that the direct band gap energy was 1.65 eV and, two direct allowed transition of 1.57 and 1.91 eV for polycrystalline and amorphized thin films, respectively. The PL spectra of Sb2S3 showed an emission peak at 1.65 eV for both films. In order to obtain current-voltage (I-V) characteristics, two cells based on the Sb2S3 thin films as both an absorbing material and an electrolyte were designed and made. The observed Sb2S3 thin films, with a thickness of around 10 mu m, are of p-type. The exponential growth of the I-V curves reveals that the cells can work as a generator of electricity. (C) The Minerals, Metals and Materials Society and ASM International 2015
PB  - Springer
T2  - Metallurgical and Materials Transactions. A: Physical Metallurgy and Materials Science
T1  - Structural, Optical, and Electrical Properties of Applied Amorphized and Polycrystalline Sb2S3 Thin Films
VL  - 47A
IS  - 3
SP  - 1460
EP  - 1468
DO  - 10.1007/s11661-015-3282-9
ER  - 
@article{
author = "Janošević, Valentina and Mitrić, Miodrag and Savić, Jasmina and Validžić, Ivana Lj.",
year = "2016",
abstract = "One of the intermediate steps in the organo-colloidal synthesis of crystalline Sb2S3 is a synthesis of spherical amorphous Sb2S3. In order to prove that the synthesized semiconductor can be considered an absorbing material for a solar device, the electronic and photovoltage properties of the amorphized and polycrystalline Sb2S3 thin films deposited by synthesized amorphous nanoparticles were studied. Optical studies revealed that the direct band gap energy was 1.65 eV and, two direct allowed transition of 1.57 and 1.91 eV for polycrystalline and amorphized thin films, respectively. The PL spectra of Sb2S3 showed an emission peak at 1.65 eV for both films. In order to obtain current-voltage (I-V) characteristics, two cells based on the Sb2S3 thin films as both an absorbing material and an electrolyte were designed and made. The observed Sb2S3 thin films, with a thickness of around 10 mu m, are of p-type. The exponential growth of the I-V curves reveals that the cells can work as a generator of electricity. (C) The Minerals, Metals and Materials Society and ASM International 2015",
publisher = "Springer",
journal = "Metallurgical and Materials Transactions. A: Physical Metallurgy and Materials Science",
title = "Structural, Optical, and Electrical Properties of Applied Amorphized and Polycrystalline Sb2S3 Thin Films",
volume = "47A",
number = "3",
pages = "1460-1468",
doi = "10.1007/s11661-015-3282-9"
}
Janošević, V., Mitrić, M., Savić, J.,& Validžić, I. Lj.. (2016). Structural, Optical, and Electrical Properties of Applied Amorphized and Polycrystalline Sb2S3 Thin Films. in Metallurgical and Materials Transactions. A: Physical Metallurgy and Materials Science
Springer., 47A(3), 1460-1468.
https://doi.org/10.1007/s11661-015-3282-9
Janošević V, Mitrić M, Savić J, Validžić IL. Structural, Optical, and Electrical Properties of Applied Amorphized and Polycrystalline Sb2S3 Thin Films. in Metallurgical and Materials Transactions. A: Physical Metallurgy and Materials Science. 2016;47A(3):1460-1468.
doi:10.1007/s11661-015-3282-9 .
Janošević, Valentina, Mitrić, Miodrag, Savić, Jasmina, Validžić, Ivana Lj., "Structural, Optical, and Electrical Properties of Applied Amorphized and Polycrystalline Sb2S3 Thin Films" in Metallurgical and Materials Transactions. A: Physical Metallurgy and Materials Science, 47A, no. 3 (2016):1460-1468,
https://doi.org/10.1007/s11661-015-3282-9 . .
7
8
8

Influence of substrate temperature and annealing on structural and optical properties of TiO2 films deposited by reactive e-beam evaporation

Pjević, Dejan J.; Marinković, Tijana; Savić, Jasmina; Bundaleski, Nenad; Obradović, Marko O.; Milosavljević, Momir; Kulik, M.

(2015)

TY  - JOUR
AU  - Pjević, Dejan J.
AU  - Marinković, Tijana
AU  - Savić, Jasmina
AU  - Bundaleski, Nenad
AU  - Obradović, Marko O.
AU  - Milosavljević, Momir
AU  - Kulik, M.
PY  - 2015
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/7079
AB  - The influence of deposition and post-deposition annealing parameters on the structure and optical properties of TiO2 thin films synthesized by reactive e-beam evaporation is reported. Pure Ti (99.9%) was evaporated in oxygen atmosphere to form thin films on Si (100) and glass substrates. Depositions were conducted on substrates held at room temperature and at 200-400 degrees C heated substrates. Post-deposition annealing was done for 3 h at 500 degrees C in air. Compositional and structural studies were performed by Rutherford backscattering spectrometry, X-ray diffraction, and X-ray photoelectron spectroscopy, and optical properties were studied by ultraviolet-visible spectroscopy and analytically by pointwise unconstrained minimization approach method. It was found that both the structure and optical properties of the films are strongly influenced by the deposition and processing parameters. All deposited samples showed good stoichiometry of Ti:O similar to 1:2. Depending on the substrate temperature and oxygen pressure in the chamber during the deposition, anatase-rutile mixed films were obtained, and in some cases TiO and Ti2O3 phases were observed. Substrate deposition temperature appears to play the major role on the final structure of the films, while post-deposition annealing adds up for the lack of oxygen in some cases and invokes crystal grain growth of already initiated phases. The results can be interesting towards the development of TiO2 thin films with defined structure and optical properties. (C) 2015 Elsevier B.V. All rights reserved.
T2  - Thin Solid Films
T1  - Influence of substrate temperature and annealing on structural and optical properties of TiO2 films deposited by reactive e-beam evaporation
VL  - 591
SP  - 224
EP  - 229
DO  - 10.1016/j.tsf.2015.03.012
ER  - 
@article{
author = "Pjević, Dejan J. and Marinković, Tijana and Savić, Jasmina and Bundaleski, Nenad and Obradović, Marko O. and Milosavljević, Momir and Kulik, M.",
year = "2015",
abstract = "The influence of deposition and post-deposition annealing parameters on the structure and optical properties of TiO2 thin films synthesized by reactive e-beam evaporation is reported. Pure Ti (99.9%) was evaporated in oxygen atmosphere to form thin films on Si (100) and glass substrates. Depositions were conducted on substrates held at room temperature and at 200-400 degrees C heated substrates. Post-deposition annealing was done for 3 h at 500 degrees C in air. Compositional and structural studies were performed by Rutherford backscattering spectrometry, X-ray diffraction, and X-ray photoelectron spectroscopy, and optical properties were studied by ultraviolet-visible spectroscopy and analytically by pointwise unconstrained minimization approach method. It was found that both the structure and optical properties of the films are strongly influenced by the deposition and processing parameters. All deposited samples showed good stoichiometry of Ti:O similar to 1:2. Depending on the substrate temperature and oxygen pressure in the chamber during the deposition, anatase-rutile mixed films were obtained, and in some cases TiO and Ti2O3 phases were observed. Substrate deposition temperature appears to play the major role on the final structure of the films, while post-deposition annealing adds up for the lack of oxygen in some cases and invokes crystal grain growth of already initiated phases. The results can be interesting towards the development of TiO2 thin films with defined structure and optical properties. (C) 2015 Elsevier B.V. All rights reserved.",
journal = "Thin Solid Films",
title = "Influence of substrate temperature and annealing on structural and optical properties of TiO2 films deposited by reactive e-beam evaporation",
volume = "591",
pages = "224-229",
doi = "10.1016/j.tsf.2015.03.012"
}
Pjević, D. J., Marinković, T., Savić, J., Bundaleski, N., Obradović, M. O., Milosavljević, M.,& Kulik, M.. (2015). Influence of substrate temperature and annealing on structural and optical properties of TiO2 films deposited by reactive e-beam evaporation. in Thin Solid Films, 591, 224-229.
https://doi.org/10.1016/j.tsf.2015.03.012
Pjević DJ, Marinković T, Savić J, Bundaleski N, Obradović MO, Milosavljević M, Kulik M. Influence of substrate temperature and annealing on structural and optical properties of TiO2 films deposited by reactive e-beam evaporation. in Thin Solid Films. 2015;591:224-229.
doi:10.1016/j.tsf.2015.03.012 .
Pjević, Dejan J., Marinković, Tijana, Savić, Jasmina, Bundaleski, Nenad, Obradović, Marko O., Milosavljević, Momir, Kulik, M., "Influence of substrate temperature and annealing on structural and optical properties of TiO2 films deposited by reactive e-beam evaporation" in Thin Solid Films, 591 (2015):224-229,
https://doi.org/10.1016/j.tsf.2015.03.012 . .
12
15
15

Brain Injury Alters Ectonucleotidase Activities and Adenine Nucleotide Levels in Rat Serum

Laketa, Danijela; Savić, Jasmina; Bjelobaba, Ivana; Lavrnja, Irene; Vasić, Vesna M.; Stojiljković, Mirjana; Nedeljkovic, Nadezda

(2015)

TY  - JOUR
AU  - Laketa, Danijela
AU  - Savić, Jasmina
AU  - Bjelobaba, Ivana
AU  - Lavrnja, Irene
AU  - Vasić, Vesna M.
AU  - Stojiljković, Mirjana
AU  - Nedeljkovic, Nadezda
PY  - 2015
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/385
AB  - Background: Cortical stab injury (CSI) induces changes in the activity, expression and cellular distribution of specific ectonucleotidases at the injury site. Also, several experimentally induced neuropathologies are associated with changes in soluble ectonucleotidase activities in the plasma and serum, whilst various insults to the brain alter purine compounds levels in cerebrospinal fluid, but also in serum, indicating that insults to the brain may induce alterations in nucleotides release and rate of their hydrolysis in the vascular system. Since adenine nucleotides and adenosine regulate diverse cellular functions in the vascular system, including vascular tone, platelet aggregation and inflammatory responses of lymphocytes and macrophages, alterations of ectonucleotidase activities in the vascular system may be relevant for the clinical outcome of the primary insult. Methods: We explored ectonucleotidase activities using specific enzyme assays and determined adenine nucleotides concentrations by the UPLC method in the rat serum after cortical stab injury. Results: At 4-h post-injury, ATP and AMP hydrolysis increased by about 60% and 40%, respectively, while phosphodiesterase activity remained unchanged. Also, at 4-h postinjury a marked decrease in ATP concentration and more than 2-fold increase in AMP concentration were recorded. Conclusions: CSI induces rapid up-regulation of nucleotide catabolizing soluble ectonucleotidases in rat serum, which leads to the observed shift in serum nucleotide levels. The results obtained imply that ectonucleotidases and adenine nucleotides participate in the communication between the brain and the vascular system in physiological and pathological conditions and thereby may be involved in the development of various human neuropathologies.
T2  - Journal of Medical Biochemistry
T1  - Brain Injury Alters Ectonucleotidase Activities and Adenine Nucleotide Levels in Rat Serum
VL  - 34
IS  - 2
SP  - 215
EP  - 222
DO  - 10.2478/jomb-2014-0025
ER  - 
@article{
author = "Laketa, Danijela and Savić, Jasmina and Bjelobaba, Ivana and Lavrnja, Irene and Vasić, Vesna M. and Stojiljković, Mirjana and Nedeljkovic, Nadezda",
year = "2015",
abstract = "Background: Cortical stab injury (CSI) induces changes in the activity, expression and cellular distribution of specific ectonucleotidases at the injury site. Also, several experimentally induced neuropathologies are associated with changes in soluble ectonucleotidase activities in the plasma and serum, whilst various insults to the brain alter purine compounds levels in cerebrospinal fluid, but also in serum, indicating that insults to the brain may induce alterations in nucleotides release and rate of their hydrolysis in the vascular system. Since adenine nucleotides and adenosine regulate diverse cellular functions in the vascular system, including vascular tone, platelet aggregation and inflammatory responses of lymphocytes and macrophages, alterations of ectonucleotidase activities in the vascular system may be relevant for the clinical outcome of the primary insult. Methods: We explored ectonucleotidase activities using specific enzyme assays and determined adenine nucleotides concentrations by the UPLC method in the rat serum after cortical stab injury. Results: At 4-h post-injury, ATP and AMP hydrolysis increased by about 60% and 40%, respectively, while phosphodiesterase activity remained unchanged. Also, at 4-h postinjury a marked decrease in ATP concentration and more than 2-fold increase in AMP concentration were recorded. Conclusions: CSI induces rapid up-regulation of nucleotide catabolizing soluble ectonucleotidases in rat serum, which leads to the observed shift in serum nucleotide levels. The results obtained imply that ectonucleotidases and adenine nucleotides participate in the communication between the brain and the vascular system in physiological and pathological conditions and thereby may be involved in the development of various human neuropathologies.",
journal = "Journal of Medical Biochemistry",
title = "Brain Injury Alters Ectonucleotidase Activities and Adenine Nucleotide Levels in Rat Serum",
volume = "34",
number = "2",
pages = "215-222",
doi = "10.2478/jomb-2014-0025"
}
Laketa, D., Savić, J., Bjelobaba, I., Lavrnja, I., Vasić, V. M., Stojiljković, M.,& Nedeljkovic, N.. (2015). Brain Injury Alters Ectonucleotidase Activities and Adenine Nucleotide Levels in Rat Serum. in Journal of Medical Biochemistry, 34(2), 215-222.
https://doi.org/10.2478/jomb-2014-0025
Laketa D, Savić J, Bjelobaba I, Lavrnja I, Vasić VM, Stojiljković M, Nedeljkovic N. Brain Injury Alters Ectonucleotidase Activities and Adenine Nucleotide Levels in Rat Serum. in Journal of Medical Biochemistry. 2015;34(2):215-222.
doi:10.2478/jomb-2014-0025 .
Laketa, Danijela, Savić, Jasmina, Bjelobaba, Ivana, Lavrnja, Irene, Vasić, Vesna M., Stojiljković, Mirjana, Nedeljkovic, Nadezda, "Brain Injury Alters Ectonucleotidase Activities and Adenine Nucleotide Levels in Rat Serum" in Journal of Medical Biochemistry, 34, no. 2 (2015):215-222,
https://doi.org/10.2478/jomb-2014-0025 . .
7
8
8

Inhibition of Na+/K+-ATPase and cytotoxicity of a few selected gold(III) complexes

Petrović, Voin; Petrović, Sandra; Joksić, Gordana; Savić, Jasmina; Čolović, Mirjana B.; Cinellu, Maria Agostina; Massai, Lara; Messori, Luigi; Vasić, Vesna M.

(2014)

TY  - JOUR
AU  - Petrović, Voin
AU  - Petrović, Sandra
AU  - Joksić, Gordana
AU  - Savić, Jasmina
AU  - Čolović, Mirjana B.
AU  - Cinellu, Maria Agostina
AU  - Massai, Lara
AU  - Messori, Luigi
AU  - Vasić, Vesna M.
PY  - 2014
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/140
AB  - Na+/K+-ATPase is in charge of maintaining the ionic and osmotic intracellular balance by using ATP as an energy source to drive excess Na+ ions out of the cell in exchange for K+ ions. We explored whether three representative cytotoxic gold(III) compounds might interfere with Na+/K+-ATPase and cause its inhibition at pharmacologically relevant concentrations. The tested complexes were [Au(bipy)(OH)(2)][PF6] (bipy = 2,2-bipyridine), [Au (py(dmb)-H)(CH3COO)(2)] (py(dmb)-H = deprotonated 6-(1,1-dimethylbenzyl)-pyridine), and [Au(bipy(dmb)-H)(OH)][PF6] (bipy(dmb)-H = deprotonated 6-(1,1-dimethylbenzyl)-2,2-bipyridine). We found that all of them caused a pronounced and similar inhibition of Na+/K+-ATPase activity. Inhibition was found to be non-competitive and reversible. Remarkably, treatment with cysteine resulted in reversal or prevention of Na+/K+-ATPase inhibition. It is very likely that the described effects may contribute to the overall cytotoxic profile of these gold complexes. (C) 2014 Elsevier Inc. All rights reserved.
T2  - Journal of Inorganic Biochemistry
T1  - Inhibition of Na+/K+-ATPase and cytotoxicity of a few selected gold(III) complexes
VL  - 140
SP  - 228
EP  - 235
DO  - 10.1016/j.jinorgbio.2014.07.015
ER  - 
@article{
author = "Petrović, Voin and Petrović, Sandra and Joksić, Gordana and Savić, Jasmina and Čolović, Mirjana B. and Cinellu, Maria Agostina and Massai, Lara and Messori, Luigi and Vasić, Vesna M.",
year = "2014",
abstract = "Na+/K+-ATPase is in charge of maintaining the ionic and osmotic intracellular balance by using ATP as an energy source to drive excess Na+ ions out of the cell in exchange for K+ ions. We explored whether three representative cytotoxic gold(III) compounds might interfere with Na+/K+-ATPase and cause its inhibition at pharmacologically relevant concentrations. The tested complexes were [Au(bipy)(OH)(2)][PF6] (bipy = 2,2-bipyridine), [Au (py(dmb)-H)(CH3COO)(2)] (py(dmb)-H = deprotonated 6-(1,1-dimethylbenzyl)-pyridine), and [Au(bipy(dmb)-H)(OH)][PF6] (bipy(dmb)-H = deprotonated 6-(1,1-dimethylbenzyl)-2,2-bipyridine). We found that all of them caused a pronounced and similar inhibition of Na+/K+-ATPase activity. Inhibition was found to be non-competitive and reversible. Remarkably, treatment with cysteine resulted in reversal or prevention of Na+/K+-ATPase inhibition. It is very likely that the described effects may contribute to the overall cytotoxic profile of these gold complexes. (C) 2014 Elsevier Inc. All rights reserved.",
journal = "Journal of Inorganic Biochemistry",
title = "Inhibition of Na+/K+-ATPase and cytotoxicity of a few selected gold(III) complexes",
volume = "140",
pages = "228-235",
doi = "10.1016/j.jinorgbio.2014.07.015"
}
Petrović, V., Petrović, S., Joksić, G., Savić, J., Čolović, M. B., Cinellu, M. A., Massai, L., Messori, L.,& Vasić, V. M.. (2014). Inhibition of Na+/K+-ATPase and cytotoxicity of a few selected gold(III) complexes. in Journal of Inorganic Biochemistry, 140, 228-235.
https://doi.org/10.1016/j.jinorgbio.2014.07.015
Petrović V, Petrović S, Joksić G, Savić J, Čolović MB, Cinellu MA, Massai L, Messori L, Vasić VM. Inhibition of Na+/K+-ATPase and cytotoxicity of a few selected gold(III) complexes. in Journal of Inorganic Biochemistry. 2014;140:228-235.
doi:10.1016/j.jinorgbio.2014.07.015 .
Petrović, Voin, Petrović, Sandra, Joksić, Gordana, Savić, Jasmina, Čolović, Mirjana B., Cinellu, Maria Agostina, Massai, Lara, Messori, Luigi, Vasić, Vesna M., "Inhibition of Na+/K+-ATPase and cytotoxicity of a few selected gold(III) complexes" in Journal of Inorganic Biochemistry, 140 (2014):228-235,
https://doi.org/10.1016/j.jinorgbio.2014.07.015 . .
8
8
7

Oxidation of diazinon and malathion by myeloperoxidase

Lazarević-Pašti, Tamara; Čolović, Mirjana B.; Savić, Jasmina; Momić, Tatjana; Vasić, Vesna M.

(2011)

TY  - JOUR
AU  - Lazarević-Pašti, Tamara
AU  - Čolović, Mirjana B.
AU  - Savić, Jasmina
AU  - Momić, Tatjana
AU  - Vasić, Vesna M.
PY  - 2011
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/4332
AB  - The aim of the work was to investigate the in vitro oxidation of diazinon and malathion, organophosphorous pesticides (OPs) containing phosphorthioate group, catalyzed by enzyme myeloperoxidase (MPO). The oxidation was performed in the presence of hydrogen peroxide. The products were identified as oxon derivatives (phosphates), where the sulfur atom from thioate group was substituted by an oxygen atom. No hydrolysis products were detected after enzyme - induced oxidation. The oxidation efficiency was controlled using acethylcholinesterase (AChE) bioassay for determination of oxon derivatives concentration. The influence of OPs concentration, incubation time of OPs with MPO, as well as MPO concentration on the yield of oxo forms was investigated. Kinetic constants of MPO in oxidation of malathion and diazinon were estimated. The maximum concentration of oxo forms was achieved after 10 min incubation of OPs in 50 mM phosphate buffer (pH 6.0) with 100 nM MPO. (C) 2011 Elsevier Inc. All rights reserved.
T2  - Pesticide Biochemistry and Physiology
T1  - Oxidation of diazinon and malathion by myeloperoxidase
VL  - 100
IS  - 2
SP  - 140
EP  - 144
DO  - 10.1016/j.pestbp.2011.03.001
ER  - 
@article{
author = "Lazarević-Pašti, Tamara and Čolović, Mirjana B. and Savić, Jasmina and Momić, Tatjana and Vasić, Vesna M.",
year = "2011",
abstract = "The aim of the work was to investigate the in vitro oxidation of diazinon and malathion, organophosphorous pesticides (OPs) containing phosphorthioate group, catalyzed by enzyme myeloperoxidase (MPO). The oxidation was performed in the presence of hydrogen peroxide. The products were identified as oxon derivatives (phosphates), where the sulfur atom from thioate group was substituted by an oxygen atom. No hydrolysis products were detected after enzyme - induced oxidation. The oxidation efficiency was controlled using acethylcholinesterase (AChE) bioassay for determination of oxon derivatives concentration. The influence of OPs concentration, incubation time of OPs with MPO, as well as MPO concentration on the yield of oxo forms was investigated. Kinetic constants of MPO in oxidation of malathion and diazinon were estimated. The maximum concentration of oxo forms was achieved after 10 min incubation of OPs in 50 mM phosphate buffer (pH 6.0) with 100 nM MPO. (C) 2011 Elsevier Inc. All rights reserved.",
journal = "Pesticide Biochemistry and Physiology",
title = "Oxidation of diazinon and malathion by myeloperoxidase",
volume = "100",
number = "2",
pages = "140-144",
doi = "10.1016/j.pestbp.2011.03.001"
}
Lazarević-Pašti, T., Čolović, M. B., Savić, J., Momić, T.,& Vasić, V. M.. (2011). Oxidation of diazinon and malathion by myeloperoxidase. in Pesticide Biochemistry and Physiology, 100(2), 140-144.
https://doi.org/10.1016/j.pestbp.2011.03.001
Lazarević-Pašti T, Čolović MB, Savić J, Momić T, Vasić VM. Oxidation of diazinon and malathion by myeloperoxidase. in Pesticide Biochemistry and Physiology. 2011;100(2):140-144.
doi:10.1016/j.pestbp.2011.03.001 .
Lazarević-Pašti, Tamara, Čolović, Mirjana B., Savić, Jasmina, Momić, Tatjana, Vasić, Vesna M., "Oxidation of diazinon and malathion by myeloperoxidase" in Pesticide Biochemistry and Physiology, 100, no. 2 (2011):140-144,
https://doi.org/10.1016/j.pestbp.2011.03.001 . .
17
13
15

Biochemical characterization of soluble nucleotide pyrophosphatase/phosphodiesterase activity in rat serum

Laketa, Danijela; Bjelobaba, Ivana; Savić, Jasmina; Lavrnja, Irena; Stojiljković, Mirjana; Rakić, Ljubisav; Nedeljkovic, Nadezda

(2010)

TY  - JOUR
AU  - Laketa, Danijela
AU  - Bjelobaba, Ivana
AU  - Savić, Jasmina
AU  - Lavrnja, Irena
AU  - Stojiljković, Mirjana
AU  - Rakić, Ljubisav
AU  - Nedeljkovic, Nadezda
PY  - 2010
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/3996
AB  - Biochemical properties of nucleotide pyrophosphatase/phosphodiesterase (NPP) in rat serum have been described by assessing its nucleotide phosphodiesterase activity, using p-nitrophenyl-5-thymidine monophosphate (p-Nph-5-TMP) as a substrate. It was demonstrated that NPP activity shares some typical characteristics described for other soluble NPP, such as divalent cation dependence, strong alkaline pH optimum (pH 10.5), inhibition by glycosaminoglycans, and K (m) for p-Nph-5-TMP hydrolysis of 61.8 +/- A 5.2 mu M. In order to characterize the relation between phosphodiesterase and pyrophosphatase activities of NPP, we have analyzed the effects of different natural nucleotides and nucleotide analogs. ATP, ADP, and AMP competitively inhibited p-Nph-5-TMP hydrolysis with K (i) values ranging 13-43 mu M. Nucleotide analogs, alpha,beta-metATP, BzATP, 2-MeSATP, and dialATP behaved as competitive inhibitors, whereas alpha,beta-metADP induced mixed inhibition, with K (i) ranging from 2 to 20 mu M. Chromatographic analysis revealed that alpha,beta-metATP, BzATP, and 2-MeSATP were catalytically degraded in the serum, whereas dialATP and alpha,beta-metADP resisted hydrolysis, implying that the former act as substrates and the latter as true competitive inhibitors of serum NPP activity. Since NPP activity is involved in generation, breakdown, and recycling of extracellular adenine nucleotides in the vascular compartment, the results suggest that both hydrolyzable and non-hydrolyzable nucleotide analogs could alter the amplitude and direction of ATP actions and could have potential therapeutic application.
T2  - Molecular and Cellular Biochemistry
T1  - Biochemical characterization of soluble nucleotide pyrophosphatase/phosphodiesterase activity in rat serum
VL  - 339
IS  - 1-2
SP  - 99
EP  - 106
DO  - 10.1007/s11010-009-0373-1
ER  - 
@article{
author = "Laketa, Danijela and Bjelobaba, Ivana and Savić, Jasmina and Lavrnja, Irena and Stojiljković, Mirjana and Rakić, Ljubisav and Nedeljkovic, Nadezda",
year = "2010",
abstract = "Biochemical properties of nucleotide pyrophosphatase/phosphodiesterase (NPP) in rat serum have been described by assessing its nucleotide phosphodiesterase activity, using p-nitrophenyl-5-thymidine monophosphate (p-Nph-5-TMP) as a substrate. It was demonstrated that NPP activity shares some typical characteristics described for other soluble NPP, such as divalent cation dependence, strong alkaline pH optimum (pH 10.5), inhibition by glycosaminoglycans, and K (m) for p-Nph-5-TMP hydrolysis of 61.8 +/- A 5.2 mu M. In order to characterize the relation between phosphodiesterase and pyrophosphatase activities of NPP, we have analyzed the effects of different natural nucleotides and nucleotide analogs. ATP, ADP, and AMP competitively inhibited p-Nph-5-TMP hydrolysis with K (i) values ranging 13-43 mu M. Nucleotide analogs, alpha,beta-metATP, BzATP, 2-MeSATP, and dialATP behaved as competitive inhibitors, whereas alpha,beta-metADP induced mixed inhibition, with K (i) ranging from 2 to 20 mu M. Chromatographic analysis revealed that alpha,beta-metATP, BzATP, and 2-MeSATP were catalytically degraded in the serum, whereas dialATP and alpha,beta-metADP resisted hydrolysis, implying that the former act as substrates and the latter as true competitive inhibitors of serum NPP activity. Since NPP activity is involved in generation, breakdown, and recycling of extracellular adenine nucleotides in the vascular compartment, the results suggest that both hydrolyzable and non-hydrolyzable nucleotide analogs could alter the amplitude and direction of ATP actions and could have potential therapeutic application.",
journal = "Molecular and Cellular Biochemistry",
title = "Biochemical characterization of soluble nucleotide pyrophosphatase/phosphodiesterase activity in rat serum",
volume = "339",
number = "1-2",
pages = "99-106",
doi = "10.1007/s11010-009-0373-1"
}
Laketa, D., Bjelobaba, I., Savić, J., Lavrnja, I., Stojiljković, M., Rakić, L.,& Nedeljkovic, N.. (2010). Biochemical characterization of soluble nucleotide pyrophosphatase/phosphodiesterase activity in rat serum. in Molecular and Cellular Biochemistry, 339(1-2), 99-106.
https://doi.org/10.1007/s11010-009-0373-1
Laketa D, Bjelobaba I, Savić J, Lavrnja I, Stojiljković M, Rakić L, Nedeljkovic N. Biochemical characterization of soluble nucleotide pyrophosphatase/phosphodiesterase activity in rat serum. in Molecular and Cellular Biochemistry. 2010;339(1-2):99-106.
doi:10.1007/s11010-009-0373-1 .
Laketa, Danijela, Bjelobaba, Ivana, Savić, Jasmina, Lavrnja, Irena, Stojiljković, Mirjana, Rakić, Ljubisav, Nedeljkovic, Nadezda, "Biochemical characterization of soluble nucleotide pyrophosphatase/phosphodiesterase activity in rat serum" in Molecular and Cellular Biochemistry, 339, no. 1-2 (2010):99-106,
https://doi.org/10.1007/s11010-009-0373-1 . .
9
10
10

Flavonoids as matrices for MALDI-TOF mass spectrometric analysis of transition metal complexes

Petković, Marijana; Petrović, Biljana; Savić, Jasmina; Bugarčić, Živadin D.; Dimitrić-Marković, Jasmina; Momić, Tatjana; Vasić, Vesna M.

(2010)

TY  - JOUR
AU  - Petković, Marijana
AU  - Petrović, Biljana
AU  - Savić, Jasmina
AU  - Bugarčić, Živadin D.
AU  - Dimitrić-Marković, Jasmina
AU  - Momić, Tatjana
AU  - Vasić, Vesna M.
PY  - 2010
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/3909
AB  - Matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a suitable method for the analysis of inorganic and organic compounds and biomolecules This makes. MALDI-TOF MS convenient for monitoring the interaction of metallo-drugs with biomolecules. Results presented in this manuscript demonstrate that flavonoids such as apigenin, kaempferol and luteolin are suitable for MALDI-TOF MS analysis of Pt(II), Pd(II), Pt(IV) and Ru(III) complexes, giving different signal-to-noise ratios of the analyte peak. The MALDI-TOF mass spectra of inorganic complexes acquired with these flavonoid matrices are easy to interpret and have some advantages over the application of other commonly used matrices: a low number of matrix peaks are detectable and the coordinative metal-ligand bond is, in most cases, preserved. On the other hand, flavonoids do not act as typical matrices, as their excess is not required for the acquisition of MALDI-TOF mass spectra of inorganic complexes. (C) 2009 Elsevier B.V. All rights reserved.
T2  - International Journal of Mass Spectrometry
T1  - Flavonoids as matrices for MALDI-TOF mass spectrometric analysis of transition metal complexes
VL  - 290
IS  - 1
SP  - 39
EP  - 46
DO  - 10.1016/j.ijms.2009.12.001
ER  - 
@article{
author = "Petković, Marijana and Petrović, Biljana and Savić, Jasmina and Bugarčić, Živadin D. and Dimitrić-Marković, Jasmina and Momić, Tatjana and Vasić, Vesna M.",
year = "2010",
abstract = "Matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a suitable method for the analysis of inorganic and organic compounds and biomolecules This makes. MALDI-TOF MS convenient for monitoring the interaction of metallo-drugs with biomolecules. Results presented in this manuscript demonstrate that flavonoids such as apigenin, kaempferol and luteolin are suitable for MALDI-TOF MS analysis of Pt(II), Pd(II), Pt(IV) and Ru(III) complexes, giving different signal-to-noise ratios of the analyte peak. The MALDI-TOF mass spectra of inorganic complexes acquired with these flavonoid matrices are easy to interpret and have some advantages over the application of other commonly used matrices: a low number of matrix peaks are detectable and the coordinative metal-ligand bond is, in most cases, preserved. On the other hand, flavonoids do not act as typical matrices, as their excess is not required for the acquisition of MALDI-TOF mass spectra of inorganic complexes. (C) 2009 Elsevier B.V. All rights reserved.",
journal = "International Journal of Mass Spectrometry",
title = "Flavonoids as matrices for MALDI-TOF mass spectrometric analysis of transition metal complexes",
volume = "290",
number = "1",
pages = "39-46",
doi = "10.1016/j.ijms.2009.12.001"
}
Petković, M., Petrović, B., Savić, J., Bugarčić, Ž. D., Dimitrić-Marković, J., Momić, T.,& Vasić, V. M.. (2010). Flavonoids as matrices for MALDI-TOF mass spectrometric analysis of transition metal complexes. in International Journal of Mass Spectrometry, 290(1), 39-46.
https://doi.org/10.1016/j.ijms.2009.12.001
Petković M, Petrović B, Savić J, Bugarčić ŽD, Dimitrić-Marković J, Momić T, Vasić VM. Flavonoids as matrices for MALDI-TOF mass spectrometric analysis of transition metal complexes. in International Journal of Mass Spectrometry. 2010;290(1):39-46.
doi:10.1016/j.ijms.2009.12.001 .
Petković, Marijana, Petrović, Biljana, Savić, Jasmina, Bugarčić, Živadin D., Dimitrić-Marković, Jasmina, Momić, Tatjana, Vasić, Vesna M., "Flavonoids as matrices for MALDI-TOF mass spectrometric analysis of transition metal complexes" in International Journal of Mass Spectrometry, 290, no. 1 (2010):39-46,
https://doi.org/10.1016/j.ijms.2009.12.001 . .
18
22
21

Preparation, characterization and applicability of cellulose acetate-polyurethane blend membrane in separation techniques

Zavastin, Daniela; Cretescu, Igor; Bezdadea, Mariana; Bourceanu, Militina; Dragan, Maria; Lisa, Gabriela; Mangalagiu, Ionel; Vasić, Vesna M.; Savić, Jasmina

(2010)

TY  - JOUR
AU  - Zavastin, Daniela
AU  - Cretescu, Igor
AU  - Bezdadea, Mariana
AU  - Bourceanu, Militina
AU  - Dragan, Maria
AU  - Lisa, Gabriela
AU  - Mangalagiu, Ionel
AU  - Vasić, Vesna M.
AU  - Savić, Jasmina
PY  - 2010
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/4140
AB  - The characteristics of blend membrane, prepared from cellulose acetate and polyurethane, were investigated in order to compare its properties with membrane material from pure cellulose acetate and polyurethane. Attenuation of total reflection Fourier transform infrared spectroscopy was utilised to investigate structural properties of membranes. Membranes morphology and its thermal properties were characterized by scanning electron microscopy and thermal analysis methods (thermogravimetric analysis, differential thermal analysis and derivated thermogravimetric analysis). Besides, swelling degree, membrane permeability, diameter of membrane pores, its thickness and stability as the function of pH of prepared blend membrane were determined. The applicability of prepared blend membrane was tested by using of aqueous solutions of new textile dye and its complex with iron(III) ions in order to test its suitability for wastewater treatment. (C) 2010 Elsevier B.V. All rights reserved.
T2  - Colloids and Surfaces. A: Physicochemical and Engineering Aspects
T1  - Preparation, characterization and applicability of cellulose acetate-polyurethane blend membrane in separation techniques
VL  - 370
IS  - 1-3
SP  - 120
EP  - 128
DO  - 10.1016/j.colsurfa.2010.08.058
ER  - 
@article{
author = "Zavastin, Daniela and Cretescu, Igor and Bezdadea, Mariana and Bourceanu, Militina and Dragan, Maria and Lisa, Gabriela and Mangalagiu, Ionel and Vasić, Vesna M. and Savić, Jasmina",
year = "2010",
abstract = "The characteristics of blend membrane, prepared from cellulose acetate and polyurethane, were investigated in order to compare its properties with membrane material from pure cellulose acetate and polyurethane. Attenuation of total reflection Fourier transform infrared spectroscopy was utilised to investigate structural properties of membranes. Membranes morphology and its thermal properties were characterized by scanning electron microscopy and thermal analysis methods (thermogravimetric analysis, differential thermal analysis and derivated thermogravimetric analysis). Besides, swelling degree, membrane permeability, diameter of membrane pores, its thickness and stability as the function of pH of prepared blend membrane were determined. The applicability of prepared blend membrane was tested by using of aqueous solutions of new textile dye and its complex with iron(III) ions in order to test its suitability for wastewater treatment. (C) 2010 Elsevier B.V. All rights reserved.",
journal = "Colloids and Surfaces. A: Physicochemical and Engineering Aspects",
title = "Preparation, characterization and applicability of cellulose acetate-polyurethane blend membrane in separation techniques",
volume = "370",
number = "1-3",
pages = "120-128",
doi = "10.1016/j.colsurfa.2010.08.058"
}
Zavastin, D., Cretescu, I., Bezdadea, M., Bourceanu, M., Dragan, M., Lisa, G., Mangalagiu, I., Vasić, V. M.,& Savić, J.. (2010). Preparation, characterization and applicability of cellulose acetate-polyurethane blend membrane in separation techniques. in Colloids and Surfaces. A: Physicochemical and Engineering Aspects, 370(1-3), 120-128.
https://doi.org/10.1016/j.colsurfa.2010.08.058
Zavastin D, Cretescu I, Bezdadea M, Bourceanu M, Dragan M, Lisa G, Mangalagiu I, Vasić VM, Savić J. Preparation, characterization and applicability of cellulose acetate-polyurethane blend membrane in separation techniques. in Colloids and Surfaces. A: Physicochemical and Engineering Aspects. 2010;370(1-3):120-128.
doi:10.1016/j.colsurfa.2010.08.058 .
Zavastin, Daniela, Cretescu, Igor, Bezdadea, Mariana, Bourceanu, Militina, Dragan, Maria, Lisa, Gabriela, Mangalagiu, Ionel, Vasić, Vesna M., Savić, Jasmina, "Preparation, characterization and applicability of cellulose acetate-polyurethane blend membrane in separation techniques" in Colloids and Surfaces. A: Physicochemical and Engineering Aspects, 370, no. 1-3 (2010):120-128,
https://doi.org/10.1016/j.colsurfa.2010.08.058 . .
69
76
80

Toxic effects of diazinon and its photodegradation products

Čolović, Mirjana B.; Krstić, Danijela Z.; Petrović, Sandra; Leskovac, Andreja; Joksić, Gordana; Savić, Jasmina; Franko, Mladen; Trebše, Polonca; Vasić, Vesna M.

(2010)

TY  - JOUR
AU  - Čolović, Mirjana B.
AU  - Krstić, Danijela Z.
AU  - Petrović, Sandra
AU  - Leskovac, Andreja
AU  - Joksić, Gordana
AU  - Savić, Jasmina
AU  - Franko, Mladen
AU  - Trebše, Polonca
AU  - Vasić, Vesna M.
PY  - 2010
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/3931
AB  - The toxic effects of diazinon and its irradiated Solutions were investigated using cultivated human blood cells (lymphocytes and erythrocytes) and skin fibroblasts. Ultra Performance Liquid Chromatography (UPLC)-UV/VIS system was used to monitor the disappearance of starting diazinon during 115-min photodegradation and formation of its by-products (diazoxon and 2-isopropyl-6-methyl-4-pyrimidinol (IMP)) as a function of time Dose-dependent AChE and Na+/K+-ATPase inhibition by diazinon was obtained for all investigated cells Calculated IC50 (72 h) values, in M, were 7 5 x 10(-6)/3 4 x 10(-5), 8.7 x 10(-5)/6.6 x 10(-5), and 3 0 x 10(-5)/4 6 x 10(-5) for fibroblast, erythrocyte and lymphocyte AChE/Na+/K+-ATPase, respectively. Results obtained for reference commercially purified target enzymes indicate similar sensitivity of AChE towards diazinon (IC50 (20 min)-7.8 x 10(-5) M). while diazinon concentrations below 10 mM did not noticeably affect Na+/K+-ATPase activity Besides, diazinon and IMP induced increasing incidence of micronuclei (via clastogenic mode of action) in a dose-dependent manner up to 2 x 10(-6) M and significant inhibition of cell proliferation and increased level of malondialdehyde at all investigated concentrations Although after 15-min diazinon irradiation formed products do not affect purified commercial enzymes activities, inhibitory effect of irradiated solutions on cell enzymes increased as a function of time exposure to UV light and resulted in significant reduction of AChE (LIP to 28-45%) and Na+/K+-ATPase (up to 35-40%) at the end of irradiation period Moreover, photodegradation treatment strengthened prooxidative properties of diazinon as well as its potency to induce cytogenetic damage (C) 2009 Elsevier Ireland Ltd All rights reserved.
T2  - Toxicology Letters
T1  - Toxic effects of diazinon and its photodegradation products
VL  - 193
IS  - 1
SP  - 9
EP  - 18
DO  - 10.1016/j.toxlet.2009.11.022
ER  - 
@article{
author = "Čolović, Mirjana B. and Krstić, Danijela Z. and Petrović, Sandra and Leskovac, Andreja and Joksić, Gordana and Savić, Jasmina and Franko, Mladen and Trebše, Polonca and Vasić, Vesna M.",
year = "2010",
abstract = "The toxic effects of diazinon and its irradiated Solutions were investigated using cultivated human blood cells (lymphocytes and erythrocytes) and skin fibroblasts. Ultra Performance Liquid Chromatography (UPLC)-UV/VIS system was used to monitor the disappearance of starting diazinon during 115-min photodegradation and formation of its by-products (diazoxon and 2-isopropyl-6-methyl-4-pyrimidinol (IMP)) as a function of time Dose-dependent AChE and Na+/K+-ATPase inhibition by diazinon was obtained for all investigated cells Calculated IC50 (72 h) values, in M, were 7 5 x 10(-6)/3 4 x 10(-5), 8.7 x 10(-5)/6.6 x 10(-5), and 3 0 x 10(-5)/4 6 x 10(-5) for fibroblast, erythrocyte and lymphocyte AChE/Na+/K+-ATPase, respectively. Results obtained for reference commercially purified target enzymes indicate similar sensitivity of AChE towards diazinon (IC50 (20 min)-7.8 x 10(-5) M). while diazinon concentrations below 10 mM did not noticeably affect Na+/K+-ATPase activity Besides, diazinon and IMP induced increasing incidence of micronuclei (via clastogenic mode of action) in a dose-dependent manner up to 2 x 10(-6) M and significant inhibition of cell proliferation and increased level of malondialdehyde at all investigated concentrations Although after 15-min diazinon irradiation formed products do not affect purified commercial enzymes activities, inhibitory effect of irradiated solutions on cell enzymes increased as a function of time exposure to UV light and resulted in significant reduction of AChE (LIP to 28-45%) and Na+/K+-ATPase (up to 35-40%) at the end of irradiation period Moreover, photodegradation treatment strengthened prooxidative properties of diazinon as well as its potency to induce cytogenetic damage (C) 2009 Elsevier Ireland Ltd All rights reserved.",
journal = "Toxicology Letters",
title = "Toxic effects of diazinon and its photodegradation products",
volume = "193",
number = "1",
pages = "9-18",
doi = "10.1016/j.toxlet.2009.11.022"
}
Čolović, M. B., Krstić, D. Z., Petrović, S., Leskovac, A., Joksić, G., Savić, J., Franko, M., Trebše, P.,& Vasić, V. M.. (2010). Toxic effects of diazinon and its photodegradation products. in Toxicology Letters, 193(1), 9-18.
https://doi.org/10.1016/j.toxlet.2009.11.022
Čolović MB, Krstić DZ, Petrović S, Leskovac A, Joksić G, Savić J, Franko M, Trebše P, Vasić VM. Toxic effects of diazinon and its photodegradation products. in Toxicology Letters. 2010;193(1):9-18.
doi:10.1016/j.toxlet.2009.11.022 .
Čolović, Mirjana B., Krstić, Danijela Z., Petrović, Sandra, Leskovac, Andreja, Joksić, Gordana, Savić, Jasmina, Franko, Mladen, Trebše, Polonca, Vasić, Vesna M., "Toxic effects of diazinon and its photodegradation products" in Toxicology Letters, 193, no. 1 (2010):9-18,
https://doi.org/10.1016/j.toxlet.2009.11.022 . .
13
68
64
73

Na+/K+-ATPase: Activity and inhibition

Čolović, Mirjana B.; Krstić, Danijela Z.; Krinulović, Katarina; Momić, Tatjana; Savić, Jasmina; Vujačić, Ana V.; Vasić, Vesna M.

(2009)

TY  - JOUR
AU  - Čolović, Mirjana B.
AU  - Krstić, Danijela Z.
AU  - Krinulović, Katarina
AU  - Momić, Tatjana
AU  - Savić, Jasmina
AU  - Vujačić, Ana V.
AU  - Vasić, Vesna M.
PY  - 2009
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/6815
AB  - The aim of the study was to give an overview of the mechanism of inhibition of Na+/K+-ATPase activity induced by some specific and non specific inhibitors. For this purpose, the effects of some ouabain like compounds (digoxin, gitoxin), noble metals complexes ([PtCl2DMSO2], [AuCl4](-), [PdCl4](2-), [PdCl(dien)](+), [PdCl(Me(4)dien)](+)), transition metal ions (Cu2+, Zn2+, Fe2+, Co2+), and heavy metal ions (Hg2+, Pb2+, Cd2+) on the activity of Na+/K+-ATPase from rat synaptic plasma membranes (SPM), porcine cerebral cortex and human erythrocytes were discussed.
T2  - Russian Journal of Physical Chemistry A
T1  - Na+/K+-ATPase: Activity and inhibition
VL  - 83
IS  - 9
SP  - 1602
EP  - 1608
DO  - 10.1134/S0036024409090337
ER  - 
@article{
author = "Čolović, Mirjana B. and Krstić, Danijela Z. and Krinulović, Katarina and Momić, Tatjana and Savić, Jasmina and Vujačić, Ana V. and Vasić, Vesna M.",
year = "2009",
abstract = "The aim of the study was to give an overview of the mechanism of inhibition of Na+/K+-ATPase activity induced by some specific and non specific inhibitors. For this purpose, the effects of some ouabain like compounds (digoxin, gitoxin), noble metals complexes ([PtCl2DMSO2], [AuCl4](-), [PdCl4](2-), [PdCl(dien)](+), [PdCl(Me(4)dien)](+)), transition metal ions (Cu2+, Zn2+, Fe2+, Co2+), and heavy metal ions (Hg2+, Pb2+, Cd2+) on the activity of Na+/K+-ATPase from rat synaptic plasma membranes (SPM), porcine cerebral cortex and human erythrocytes were discussed.",
journal = "Russian Journal of Physical Chemistry A",
title = "Na+/K+-ATPase: Activity and inhibition",
volume = "83",
number = "9",
pages = "1602-1608",
doi = "10.1134/S0036024409090337"
}
Čolović, M. B., Krstić, D. Z., Krinulović, K., Momić, T., Savić, J., Vujačić, A. V.,& Vasić, V. M.. (2009). Na+/K+-ATPase: Activity and inhibition. in Russian Journal of Physical Chemistry A, 83(9), 1602-1608.
https://doi.org/10.1134/S0036024409090337
Čolović MB, Krstić DZ, Krinulović K, Momić T, Savić J, Vujačić AV, Vasić VM. Na+/K+-ATPase: Activity and inhibition. in Russian Journal of Physical Chemistry A. 2009;83(9):1602-1608.
doi:10.1134/S0036024409090337 .
Čolović, Mirjana B., Krstić, Danijela Z., Krinulović, Katarina, Momić, Tatjana, Savić, Jasmina, Vujačić, Ana V., Vasić, Vesna M., "Na+/K+-ATPase: Activity and inhibition" in Russian Journal of Physical Chemistry A, 83, no. 9 (2009):1602-1608,
https://doi.org/10.1134/S0036024409090337 . .
3
6
5

Electrochemical Behaviour of Bis-Pyrazole-Azo-Chromotropic Acid and Its Use as Modifier for Elaboration of Potentiometric Sensor for the Copper Detection

Savić, Jasmina; Vasić, Vesna M.; Cristea, C.; Sandulescu, R.

(2009)

TY  - JOUR
AU  - Savić, Jasmina
AU  - Vasić, Vesna M.
AU  - Cristea, C.
AU  - Sandulescu, R.
PY  - 2009
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/3881
AB  - The electrochemical behaviour of 2,7-bis-(pyrazole-3(5)-ylazo)-1,8-dihydroxynaphtalene-3,6-disulphonic acid (bis-PACA) and its complexes with Cu(II), Cd(II), Ni(II), Pb(II) and Hg(II) was investigated using cyclic voltammetry. Experiments were performed in the concentration range from 5 x 10(-5) to 7 x 10(-4) M of bis-pyrazole-azo-chromotropic acid (bis-PACA). Linear dependence of current intensity versus bis-PACA concentration was obtained in the investigated concentration range. According to the obtained results, the process is controlled by diffusion. The elaboration of a Cu(II) selective electrode by using bis-PACA as modifier was also investigated.
T2  - Journal of Environmental Protection and Ecology
T1  - Electrochemical Behaviour of Bis-Pyrazole-Azo-Chromotropic Acid and Its Use as Modifier for Elaboration of Potentiometric Sensor for the Copper Detection
VL  - 10
IS  - 4
SP  - 1162
EP  - 1169
ER  - 
@article{
author = "Savić, Jasmina and Vasić, Vesna M. and Cristea, C. and Sandulescu, R.",
year = "2009",
abstract = "The electrochemical behaviour of 2,7-bis-(pyrazole-3(5)-ylazo)-1,8-dihydroxynaphtalene-3,6-disulphonic acid (bis-PACA) and its complexes with Cu(II), Cd(II), Ni(II), Pb(II) and Hg(II) was investigated using cyclic voltammetry. Experiments were performed in the concentration range from 5 x 10(-5) to 7 x 10(-4) M of bis-pyrazole-azo-chromotropic acid (bis-PACA). Linear dependence of current intensity versus bis-PACA concentration was obtained in the investigated concentration range. According to the obtained results, the process is controlled by diffusion. The elaboration of a Cu(II) selective electrode by using bis-PACA as modifier was also investigated.",
journal = "Journal of Environmental Protection and Ecology",
title = "Electrochemical Behaviour of Bis-Pyrazole-Azo-Chromotropic Acid and Its Use as Modifier for Elaboration of Potentiometric Sensor for the Copper Detection",
volume = "10",
number = "4",
pages = "1162-1169"
}
Savić, J., Vasić, V. M., Cristea, C.,& Sandulescu, R.. (2009). Electrochemical Behaviour of Bis-Pyrazole-Azo-Chromotropic Acid and Its Use as Modifier for Elaboration of Potentiometric Sensor for the Copper Detection. in Journal of Environmental Protection and Ecology, 10(4), 1162-1169.
Savić J, Vasić VM, Cristea C, Sandulescu R. Electrochemical Behaviour of Bis-Pyrazole-Azo-Chromotropic Acid and Its Use as Modifier for Elaboration of Potentiometric Sensor for the Copper Detection. in Journal of Environmental Protection and Ecology. 2009;10(4):1162-1169..
Savić, Jasmina, Vasić, Vesna M., Cristea, C., Sandulescu, R., "Electrochemical Behaviour of Bis-Pyrazole-Azo-Chromotropic Acid and Its Use as Modifier for Elaboration of Potentiometric Sensor for the Copper Detection" in Journal of Environmental Protection and Ecology, 10, no. 4 (2009):1162-1169.
2

Application of flavonoids - quercetin and rutin - as new matrices for matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis of Pt(II) and Pd(II) complexes

Petković, Marijana; Vujačić, Ana V.; Schiller, Jürgen; Bugarčić, Živadin D.; Savić, Jasmina; Vasić, Vesna M.

(2009)

TY  - JOUR
AU  - Petković, Marijana
AU  - Vujačić, Ana V.
AU  - Schiller, Jürgen
AU  - Bugarčić, Živadin D.
AU  - Savić, Jasmina
AU  - Vasić, Vesna M.
PY  - 2009
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/3697
AB  - Attempts are being made to overcome the resistance of tumour cells to platinum (Pt) drugs by the synthesis of new generations of Pt complexes, and it is important to find appropriate and simple methods for the characterization of those novel complexes. The additional applicability of such a method for the analysis of the interactions of metal complexes with biomolecules would be advantageous. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) seems to possess the capability to become this method of choice, since it could be applied to low-mass complexes as well as for the analysis of large biomolecules. In this work the applicability of flavonoids - quercetin and rutin - as matrices for MALDI-TOFMS analysis of dichlorido(ethylendiamine)platinum(II) ([PtCl(2)(en)]), dichlorido(diaminocyclohexane)platinum(II) ([PtCl(2)(dach)]) and chloride (diethylenetriamine) palladium(II) chloride ([PdCl(dien)]Cl) complexes is demonstrated. Spectra of Pt(II) and Pd(II) complexes recorded in the presence of quercetin and rutin are rather simple: Pt(II) complexes generate [M+Na](+) or [M+K](+)ions, whereas the investigated Pd(II) complex gives ions generated by the loss of one Cl(-) or HCl. Flavonoids give a relatively small number of well-defined ions in the low-mass region (at m/z 303.3 for quercetin and m/z 633.5 for rutin). Quercetin and rutin can be applied in much lower concentrations than other common MALDI matrices and require rather low laser intensity. We speculate that flavonoids stabilize the structures of the metal complexes and that they may be useful for the analysis of other biologically active metal complexes, thus implying their broader applicability. Copyright (C) 2009 John Wiley and Sons, Ltd.
T2  - Rapid Communications in Mass Spectrometry
T1  - Application of flavonoids - quercetin and rutin - as new matrices for matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis of Pt(II) and Pd(II) complexes
VL  - 23
IS  - 10
SP  - 1467
EP  - 1475
DO  - 10.1002/rcm.4024
ER  - 
@article{
author = "Petković, Marijana and Vujačić, Ana V. and Schiller, Jürgen and Bugarčić, Živadin D. and Savić, Jasmina and Vasić, Vesna M.",
year = "2009",
abstract = "Attempts are being made to overcome the resistance of tumour cells to platinum (Pt) drugs by the synthesis of new generations of Pt complexes, and it is important to find appropriate and simple methods for the characterization of those novel complexes. The additional applicability of such a method for the analysis of the interactions of metal complexes with biomolecules would be advantageous. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) seems to possess the capability to become this method of choice, since it could be applied to low-mass complexes as well as for the analysis of large biomolecules. In this work the applicability of flavonoids - quercetin and rutin - as matrices for MALDI-TOFMS analysis of dichlorido(ethylendiamine)platinum(II) ([PtCl(2)(en)]), dichlorido(diaminocyclohexane)platinum(II) ([PtCl(2)(dach)]) and chloride (diethylenetriamine) palladium(II) chloride ([PdCl(dien)]Cl) complexes is demonstrated. Spectra of Pt(II) and Pd(II) complexes recorded in the presence of quercetin and rutin are rather simple: Pt(II) complexes generate [M+Na](+) or [M+K](+)ions, whereas the investigated Pd(II) complex gives ions generated by the loss of one Cl(-) or HCl. Flavonoids give a relatively small number of well-defined ions in the low-mass region (at m/z 303.3 for quercetin and m/z 633.5 for rutin). Quercetin and rutin can be applied in much lower concentrations than other common MALDI matrices and require rather low laser intensity. We speculate that flavonoids stabilize the structures of the metal complexes and that they may be useful for the analysis of other biologically active metal complexes, thus implying their broader applicability. Copyright (C) 2009 John Wiley and Sons, Ltd.",
journal = "Rapid Communications in Mass Spectrometry",
title = "Application of flavonoids - quercetin and rutin - as new matrices for matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis of Pt(II) and Pd(II) complexes",
volume = "23",
number = "10",
pages = "1467-1475",
doi = "10.1002/rcm.4024"
}
Petković, M., Vujačić, A. V., Schiller, J., Bugarčić, Ž. D., Savić, J.,& Vasić, V. M.. (2009). Application of flavonoids - quercetin and rutin - as new matrices for matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis of Pt(II) and Pd(II) complexes. in Rapid Communications in Mass Spectrometry, 23(10), 1467-1475.
https://doi.org/10.1002/rcm.4024
Petković M, Vujačić AV, Schiller J, Bugarčić ŽD, Savić J, Vasić VM. Application of flavonoids - quercetin and rutin - as new matrices for matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis of Pt(II) and Pd(II) complexes. in Rapid Communications in Mass Spectrometry. 2009;23(10):1467-1475.
doi:10.1002/rcm.4024 .
Petković, Marijana, Vujačić, Ana V., Schiller, Jürgen, Bugarčić, Živadin D., Savić, Jasmina, Vasić, Vesna M., "Application of flavonoids - quercetin and rutin - as new matrices for matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis of Pt(II) and Pd(II) complexes" in Rapid Communications in Mass Spectrometry, 23, no. 10 (2009):1467-1475,
https://doi.org/10.1002/rcm.4024 . .
19
20
19

Interaction of the [PtCl2(DMSO)(2)] Complex with L-Cysteine

Vasić, Dragana D.; Savić, Jasmina; Bugaricic, Zivadin; Krstić, Danijela Z.; Tomic, Nenad; Čolović, Mirjana B.; Petković, Marijana; Vasić, Vesna M.

(2009)

TY  - JOUR
AU  - Vasić, Dragana D.
AU  - Savić, Jasmina
AU  - Bugaricic, Zivadin
AU  - Krstić, Danijela Z.
AU  - Tomic, Nenad
AU  - Čolović, Mirjana B.
AU  - Petković, Marijana
AU  - Vasić, Vesna M.
PY  - 2009
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/3657
AB  - The reaction between [PtCl,(DMSO)(2)] and L-cysteine (L-Cys) has been investigated in the presence of micelles of sodium dodecyl sulfate (SDS) - as a model for biological membranes. Additionally, the inhibitory effect of [PtCl2(DMSO)(2)] on the Na+,K+-ATPise activity and its partial prevention with 10 mM L-Cys were demonstrated. The interaction of L-Cys with [Ptcl(2)(DMSO)(2)] resulted in the formation of a [Pt(DMSO)(2)L-Cys)(2)](2+) (DMSO)(2)] Complex, which most probably occurs through stepwise replacement of Cl- with L-Cys. It has also been demonstrated that neither the pH value nor SDS affects the composition of the new complex. On the other hand, the pH value and SDS do affect the reaction rate, most probably due to electrostatic interactions with reactants. In Summary, this study can be used as a simple model approach for the investigation of reaction mechanisms between platinum complexes and various biomolecules, and for the determination of potential toxicity and/or side effects of antitumour platinum drugs.
T2  - Zeitschrift fur Naturforschung. Section C: Journal of Biosciences
T1  - Interaction of the [PtCl2(DMSO)(2)] Complex with L-Cysteine
VL  - 64
IS  - 1-2
SP  - 103
EP  - 108
ER  - 
@article{
author = "Vasić, Dragana D. and Savić, Jasmina and Bugaricic, Zivadin and Krstić, Danijela Z. and Tomic, Nenad and Čolović, Mirjana B. and Petković, Marijana and Vasić, Vesna M.",
year = "2009",
abstract = "The reaction between [PtCl,(DMSO)(2)] and L-cysteine (L-Cys) has been investigated in the presence of micelles of sodium dodecyl sulfate (SDS) - as a model for biological membranes. Additionally, the inhibitory effect of [PtCl2(DMSO)(2)] on the Na+,K+-ATPise activity and its partial prevention with 10 mM L-Cys were demonstrated. The interaction of L-Cys with [Ptcl(2)(DMSO)(2)] resulted in the formation of a [Pt(DMSO)(2)L-Cys)(2)](2+) (DMSO)(2)] Complex, which most probably occurs through stepwise replacement of Cl- with L-Cys. It has also been demonstrated that neither the pH value nor SDS affects the composition of the new complex. On the other hand, the pH value and SDS do affect the reaction rate, most probably due to electrostatic interactions with reactants. In Summary, this study can be used as a simple model approach for the investigation of reaction mechanisms between platinum complexes and various biomolecules, and for the determination of potential toxicity and/or side effects of antitumour platinum drugs.",
journal = "Zeitschrift fur Naturforschung. Section C: Journal of Biosciences",
title = "Interaction of the [PtCl2(DMSO)(2)] Complex with L-Cysteine",
volume = "64",
number = "1-2",
pages = "103-108"
}
Vasić, D. D., Savić, J., Bugaricic, Z., Krstić, D. Z., Tomic, N., Čolović, M. B., Petković, M.,& Vasić, V. M.. (2009). Interaction of the [PtCl2(DMSO)(2)] Complex with L-Cysteine. in Zeitschrift fur Naturforschung. Section C: Journal of Biosciences, 64(1-2), 103-108.
Vasić DD, Savić J, Bugaricic Z, Krstić DZ, Tomic N, Čolović MB, Petković M, Vasić VM. Interaction of the [PtCl2(DMSO)(2)] Complex with L-Cysteine. in Zeitschrift fur Naturforschung. Section C: Journal of Biosciences. 2009;64(1-2):103-108..
Vasić, Dragana D., Savić, Jasmina, Bugaricic, Zivadin, Krstić, Danijela Z., Tomic, Nenad, Čolović, Mirjana B., Petković, Marijana, Vasić, Vesna M., "Interaction of the [PtCl2(DMSO)(2)] Complex with L-Cysteine" in Zeitschrift fur Naturforschung. Section C: Journal of Biosciences, 64, no. 1-2 (2009):103-108.
12

Mechanism of complex formation between [AuCl4](-) and L-methionine

Vujačić, Ana V.; Savić, Jasmina; Sovilj, Sofija P.; Szecsenyi, K. Meszaros; Todorovic, N.; Petković, Marijana; Vasić, Vesna M.

(2009)

TY  - JOUR
AU  - Vujačić, Ana V.
AU  - Savić, Jasmina
AU  - Sovilj, Sofija P.
AU  - Szecsenyi, K. Meszaros
AU  - Todorovic, N.
AU  - Petković, Marijana
AU  - Vasić, Vesna M.
PY  - 2009
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/3653
AB  - The kinetics of the reaction between the tetrachloroaurate(III) ion and L-methionine (L-Met) (0.1 M HClO4, pH 1.0-2.5) have been studied spectrophotometrically using a stopped-flow technique at different temperatures. Initially, the fast substitution reaction was ascribed to the formation of the short-lived square-planar Au(III)-(L-Met) that was followed by the replacement of a Cl- ligand and a subsequent, slower reduction to Au(I)-(L-Met). This is an intermolecular process, involving attack on the [AuCl4](-) Complex by an outer-sphere L-methionine. The activation parameters (Delta H-not equal and Delta S-not equal) for substitution and reduction were determined. IR spectroscopy indicates that L-methionine acts as a bidentate ligand, most likely coordinating via the S and N atoms, while H-1 and C-13 NMR data indicate methionine sulfoxide as the final product. Finally, the components of the reaction were treated thermally in order to investigate the solid phase synthesis of the resulting complex. (C) 2008 Elsevier Ltd. All rights reserved.
T2  - Polyhedron
T1  - Mechanism of complex formation between [AuCl4](-) and L-methionine
VL  - 28
IS  - 3
SP  - 593
EP  - 599
DO  - 10.1016/j.poly.2008.11.045
ER  - 
@article{
author = "Vujačić, Ana V. and Savić, Jasmina and Sovilj, Sofija P. and Szecsenyi, K. Meszaros and Todorovic, N. and Petković, Marijana and Vasić, Vesna M.",
year = "2009",
abstract = "The kinetics of the reaction between the tetrachloroaurate(III) ion and L-methionine (L-Met) (0.1 M HClO4, pH 1.0-2.5) have been studied spectrophotometrically using a stopped-flow technique at different temperatures. Initially, the fast substitution reaction was ascribed to the formation of the short-lived square-planar Au(III)-(L-Met) that was followed by the replacement of a Cl- ligand and a subsequent, slower reduction to Au(I)-(L-Met). This is an intermolecular process, involving attack on the [AuCl4](-) Complex by an outer-sphere L-methionine. The activation parameters (Delta H-not equal and Delta S-not equal) for substitution and reduction were determined. IR spectroscopy indicates that L-methionine acts as a bidentate ligand, most likely coordinating via the S and N atoms, while H-1 and C-13 NMR data indicate methionine sulfoxide as the final product. Finally, the components of the reaction were treated thermally in order to investigate the solid phase synthesis of the resulting complex. (C) 2008 Elsevier Ltd. All rights reserved.",
journal = "Polyhedron",
title = "Mechanism of complex formation between [AuCl4](-) and L-methionine",
volume = "28",
number = "3",
pages = "593-599",
doi = "10.1016/j.poly.2008.11.045"
}
Vujačić, A. V., Savić, J., Sovilj, S. P., Szecsenyi, K. M., Todorovic, N., Petković, M.,& Vasić, V. M.. (2009). Mechanism of complex formation between [AuCl4](-) and L-methionine. in Polyhedron, 28(3), 593-599.
https://doi.org/10.1016/j.poly.2008.11.045
Vujačić AV, Savić J, Sovilj SP, Szecsenyi KM, Todorovic N, Petković M, Vasić VM. Mechanism of complex formation between [AuCl4](-) and L-methionine. in Polyhedron. 2009;28(3):593-599.
doi:10.1016/j.poly.2008.11.045 .
Vujačić, Ana V., Savić, Jasmina, Sovilj, Sofija P., Szecsenyi, K. Meszaros, Todorovic, N., Petković, Marijana, Vasić, Vesna M., "Mechanism of complex formation between [AuCl4](-) and L-methionine" in Polyhedron, 28, no. 3 (2009):593-599,
https://doi.org/10.1016/j.poly.2008.11.045 . .
36
39
39

Biosorption of copper(II) ions from aqua solutions using dried yeast biomass

Cojocaru, Corneliu; Diaconu, Mariana; Cretescu, Igor; Savić, Jasmina; Vasić, Vesna M.

(2009)

TY  - JOUR
AU  - Cojocaru, Corneliu
AU  - Diaconu, Mariana
AU  - Cretescu, Igor
AU  - Savić, Jasmina
AU  - Vasić, Vesna M.
PY  - 2009
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/3636
AB  - The ability of dried yeast Saccharomyces biomass to remove Cu(II) ions from aqueous solutions was investigated by using of batch techniques. The influence of different parameters on copper uptake by dried yeast, such as initial Cu(II) concentration, initial pH of solution and temperature, was studied. The Freundlich, Langmuir, Redlich-Peterson and Sips isotherms were applied to the obtained experimental data. According to Langmuir isotherm the maximum adsorption capacity of investigated non-living biomass was found to be 2.59 mg/g. The thermodynamic parameters (e.g. free energy and enthalpy) were calculated and discussed. The adsorption of Cu(II) onto the dried cells of Saccharomyces cerevisiae is an endothermic process and become more favorable with the increasing of temperature in pH range from 3 to 4. Optimization studies by means of response surface methodology were carried out, which resulted in improvement of the efficiency of sorption removal by using of biomass. The removal efficiency of real wastewater originating from electroplating industry which contains Sn(II) ions was determined and compared with synthetic wastewater obtained in laboratory. (C) 2008 Elsevier B.V. All rights reserved.
T2  - Colloids and Surfaces. A: Physicochemical and Engineering Aspects
T1  - Biosorption of copper(II) ions from aqua solutions using dried yeast biomass
VL  - 335
IS  - 1-3
SP  - 181
EP  - 188
DO  - 10.1016/j.colsurfa.2008.11.003
ER  - 
@article{
author = "Cojocaru, Corneliu and Diaconu, Mariana and Cretescu, Igor and Savić, Jasmina and Vasić, Vesna M.",
year = "2009",
abstract = "The ability of dried yeast Saccharomyces biomass to remove Cu(II) ions from aqueous solutions was investigated by using of batch techniques. The influence of different parameters on copper uptake by dried yeast, such as initial Cu(II) concentration, initial pH of solution and temperature, was studied. The Freundlich, Langmuir, Redlich-Peterson and Sips isotherms were applied to the obtained experimental data. According to Langmuir isotherm the maximum adsorption capacity of investigated non-living biomass was found to be 2.59 mg/g. The thermodynamic parameters (e.g. free energy and enthalpy) were calculated and discussed. The adsorption of Cu(II) onto the dried cells of Saccharomyces cerevisiae is an endothermic process and become more favorable with the increasing of temperature in pH range from 3 to 4. Optimization studies by means of response surface methodology were carried out, which resulted in improvement of the efficiency of sorption removal by using of biomass. The removal efficiency of real wastewater originating from electroplating industry which contains Sn(II) ions was determined and compared with synthetic wastewater obtained in laboratory. (C) 2008 Elsevier B.V. All rights reserved.",
journal = "Colloids and Surfaces. A: Physicochemical and Engineering Aspects",
title = "Biosorption of copper(II) ions from aqua solutions using dried yeast biomass",
volume = "335",
number = "1-3",
pages = "181-188",
doi = "10.1016/j.colsurfa.2008.11.003"
}
Cojocaru, C., Diaconu, M., Cretescu, I., Savić, J.,& Vasić, V. M.. (2009). Biosorption of copper(II) ions from aqua solutions using dried yeast biomass. in Colloids and Surfaces. A: Physicochemical and Engineering Aspects, 335(1-3), 181-188.
https://doi.org/10.1016/j.colsurfa.2008.11.003
Cojocaru C, Diaconu M, Cretescu I, Savić J, Vasić VM. Biosorption of copper(II) ions from aqua solutions using dried yeast biomass. in Colloids and Surfaces. A: Physicochemical and Engineering Aspects. 2009;335(1-3):181-188.
doi:10.1016/j.colsurfa.2008.11.003 .
Cojocaru, Corneliu, Diaconu, Mariana, Cretescu, Igor, Savić, Jasmina, Vasić, Vesna M., "Biosorption of copper(II) ions from aqua solutions using dried yeast biomass" in Colloids and Surfaces. A: Physicochemical and Engineering Aspects, 335, no. 1-3 (2009):181-188,
https://doi.org/10.1016/j.colsurfa.2008.11.003 . .
62
73
78

Spectrophotometric and uplc study of reaction between [AuCl4] - and quercetin

Savić, Jasmina; Momić, Tatjana; Milenković, Aleksandra S.; Vujačić, Ana V.; Vasić, Vesna M.

(Society of Physical Chemists of Serbia, 2008)

TY  - CONF
AU  - Savić, Jasmina
AU  - Momić, Tatjana
AU  - Milenković, Aleksandra S.
AU  - Vujačić, Ana V.
AU  - Vasić, Vesna M.
PY  - 2008
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9360
AB  - The equilibrium and kinetics of the reaction between tetrachloroaurate(III) ion (AuCl4 - ) and quercetin in 0.1 M HClO4 were studied spectrophotometrically. The fast and the slow reaction steps were distinguished in the reaction mechanism, depending on the ratio of AuCl4 -  and quercetin concentration. The stoichiometry of reaction, determined by molar ratio and Jobb’s methods, was 1:1. The kinetics of complex formation was followed under the pseudo-first order conditions by measuring the absorbance at 294 nm vs. time as the function of quercetin concentration in 5 – 15 fold excess.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry
T1  - Spectrophotometric and uplc study of reaction between [AuCl4] - and quercetin
VL  - 1
SP  - 172
EP  - 174
ER  - 
@conference{
author = "Savić, Jasmina and Momić, Tatjana and Milenković, Aleksandra S. and Vujačić, Ana V. and Vasić, Vesna M.",
year = "2008",
abstract = "The equilibrium and kinetics of the reaction between tetrachloroaurate(III) ion (AuCl4 - ) and quercetin in 0.1 M HClO4 were studied spectrophotometrically. The fast and the slow reaction steps were distinguished in the reaction mechanism, depending on the ratio of AuCl4 -  and quercetin concentration. The stoichiometry of reaction, determined by molar ratio and Jobb’s methods, was 1:1. The kinetics of complex formation was followed under the pseudo-first order conditions by measuring the absorbance at 294 nm vs. time as the function of quercetin concentration in 5 – 15 fold excess.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry",
title = "Spectrophotometric and uplc study of reaction between [AuCl4] - and quercetin",
volume = "1",
pages = "172-174"
}
Savić, J., Momić, T., Milenković, A. S., Vujačić, A. V.,& Vasić, V. M.. (2008). Spectrophotometric and uplc study of reaction between [AuCl4] - and quercetin. in Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry
Society of Physical Chemists of Serbia., 1, 172-174.
Savić J, Momić T, Milenković AS, Vujačić AV, Vasić VM. Spectrophotometric and uplc study of reaction between [AuCl4] - and quercetin. in Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry. 2008;1:172-174..
Savić, Jasmina, Momić, Tatjana, Milenković, Aleksandra S., Vujačić, Ana V., Vasić, Vesna M., "Spectrophotometric and uplc study of reaction between [AuCl4] - and quercetin" in Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry, 1 (2008):172-174.

Application of ultra performance liquid chromatography (uplc) for determination of Na+ /K+ atpase activity

Savić, Jasmina; Krinulović, Katarina; Momić, Tatjana; Čolović, Mirjana B.; Vujačić, Ana V.

(Society of Physical Chemists of Serbia, 2008)

TY  - CONF
AU  - Savić, Jasmina
AU  - Krinulović, Katarina
AU  - Momić, Tatjana
AU  - Čolović, Mirjana B.
AU  - Vujačić, Ana V.
PY  - 2008
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9354
AB  - An ion-pair ultra performance liquid chromatography (IP-UPLC) method was developed to obtain a sensitive and efficient means for quantification of ADP in order to follow the decrease of Na+ /K+  ATPase activity after its exposure to different inhibitors. The concentrations of ADP obtained after hydrolysis of ATP in the presence of enzyme depends on enzyme activity. Simultaneously with the chromatographic determination of ADP, the spectrophotometric determination of phosphates liberated after the hydrolysis of ATP was done.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry
T1  - Application of ultra performance liquid chromatography (uplc) for determination of Na+ /K+ atpase activity
VL  - 1
SP  - 36
EP  - 38
ER  - 
@conference{
author = "Savić, Jasmina and Krinulović, Katarina and Momić, Tatjana and Čolović, Mirjana B. and Vujačić, Ana V.",
year = "2008",
abstract = "An ion-pair ultra performance liquid chromatography (IP-UPLC) method was developed to obtain a sensitive and efficient means for quantification of ADP in order to follow the decrease of Na+ /K+  ATPase activity after its exposure to different inhibitors. The concentrations of ADP obtained after hydrolysis of ATP in the presence of enzyme depends on enzyme activity. Simultaneously with the chromatographic determination of ADP, the spectrophotometric determination of phosphates liberated after the hydrolysis of ATP was done.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry",
title = "Application of ultra performance liquid chromatography (uplc) for determination of Na+ /K+ atpase activity",
volume = "1",
pages = "36-38"
}
Savić, J., Krinulović, K., Momić, T., Čolović, M. B.,& Vujačić, A. V.. (2008). Application of ultra performance liquid chromatography (uplc) for determination of Na+ /K+ atpase activity. in Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry
Society of Physical Chemists of Serbia., 1, 36-38.
Savić J, Krinulović K, Momić T, Čolović MB, Vujačić AV. Application of ultra performance liquid chromatography (uplc) for determination of Na+ /K+ atpase activity. in Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry. 2008;1:36-38..
Savić, Jasmina, Krinulović, Katarina, Momić, Tatjana, Čolović, Mirjana B., Vujačić, Ana V., "Application of ultra performance liquid chromatography (uplc) for determination of Na+ /K+ atpase activity" in Physical chemistry 2008 : 9th international conference on fundamental and applied aspects of physical chemistry, 1 (2008):36-38.

Malathion-induced inhibition of human plasma cholinesterase studied by the fluorescence spectroscopy method

Pavelkić, Vesna M.; Krinulović, Katarina; Savić, Jasmina; Ilic, M. A.

(2008)

TY  - JOUR
AU  - Pavelkić, Vesna M.
AU  - Krinulović, Katarina
AU  - Savić, Jasmina
AU  - Ilic, M. A.
PY  - 2008
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/3444
AB  - The in vitro effect of technical grade malathion was assessed via the kinetic parameters of human plasma butyrylcholinesterase (BChE) using N-methylindoxyl acetate as a substrate for BChE. An inhibitor kinetics study demonstrated the existence of a biphasic inhibition curve, indicating high-and low-affinity binding sites of malathion. The IC (50) values as calculated from the experimental inhibition curves were 1.33 x 10(-9) and 1.48 x 10(-5) M for the high-and low-affinity binding sites, respectively; Hills analysis gave 1.29 x 10(-9) and 1.38 x 10(-6) M. The Cornish-Bowden plots and their secondary plots indicated that the nature of inhibition was of mixed type with the predominant competitive character of both affinity binding sites.
T2  - Russian Journal of Physical Chemistry A
T1  - Malathion-induced inhibition of human plasma cholinesterase studied by the fluorescence spectroscopy method
VL  - 82
IS  - 5
SP  - 870
EP  - 874
DO  - 10.1134/S0036024408050312
ER  - 
@article{
author = "Pavelkić, Vesna M. and Krinulović, Katarina and Savić, Jasmina and Ilic, M. A.",
year = "2008",
abstract = "The in vitro effect of technical grade malathion was assessed via the kinetic parameters of human plasma butyrylcholinesterase (BChE) using N-methylindoxyl acetate as a substrate for BChE. An inhibitor kinetics study demonstrated the existence of a biphasic inhibition curve, indicating high-and low-affinity binding sites of malathion. The IC (50) values as calculated from the experimental inhibition curves were 1.33 x 10(-9) and 1.48 x 10(-5) M for the high-and low-affinity binding sites, respectively; Hills analysis gave 1.29 x 10(-9) and 1.38 x 10(-6) M. The Cornish-Bowden plots and their secondary plots indicated that the nature of inhibition was of mixed type with the predominant competitive character of both affinity binding sites.",
journal = "Russian Journal of Physical Chemistry A",
title = "Malathion-induced inhibition of human plasma cholinesterase studied by the fluorescence spectroscopy method",
volume = "82",
number = "5",
pages = "870-874",
doi = "10.1134/S0036024408050312"
}
Pavelkić, V. M., Krinulović, K., Savić, J.,& Ilic, M. A.. (2008). Malathion-induced inhibition of human plasma cholinesterase studied by the fluorescence spectroscopy method. in Russian Journal of Physical Chemistry A, 82(5), 870-874.
https://doi.org/10.1134/S0036024408050312
Pavelkić VM, Krinulović K, Savić J, Ilic MA. Malathion-induced inhibition of human plasma cholinesterase studied by the fluorescence spectroscopy method. in Russian Journal of Physical Chemistry A. 2008;82(5):870-874.
doi:10.1134/S0036024408050312 .
Pavelkić, Vesna M., Krinulović, Katarina, Savić, Jasmina, Ilic, M. A., "Malathion-induced inhibition of human plasma cholinesterase studied by the fluorescence spectroscopy method" in Russian Journal of Physical Chemistry A, 82, no. 5 (2008):870-874,
https://doi.org/10.1134/S0036024408050312 . .
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Kinetic investigation of the immobilization of chromotropic acid derivatives onto anion exchange resin

Savić, Jasmina; Vasić, Vesna M.; Adnađević, Borivoj

(2007)

TY  - JOUR
AU  - Savić, Jasmina
AU  - Vasić, Vesna M.
AU  - Adnađević, Borivoj
PY  - 2007
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/3409
AB  - The adsorption kinetics of pyrazol- (PACA) and imidazol-azo-chromo-tropic acid (IACA) onto Dowex 1-X8 resin, as a function of the dye concentration and temperature were investigated at pH 4.5. The pseudo-first- and second-order kinetic models and intraparticle diffusion model were used to describe the obtained kinetic data. The adsorption rate constants were found to be in the order of magnitude 10(-2) min(-1) for all of the used kinetics models. The adsorption capacity increases with increasing initial dye concentration. The study of adsorption kinetics at different temperatures (in the range from 5 to 25 degrees C) reveals an increase in the rate of adsorption and adsorption capacity with increasing temperature. The activation energy (in the case of PACA 16.6 kJ/mol, and for IACA 11.3 kJ/mol) was determined using the Arrhenius dependence. Electrostatic interactions between the dye and resin beads were shown to be the adsorption mechanism.
T2  - Hemijska industrija
T1  - Kinetic investigation of the immobilization of chromotropic acid derivatives onto anion exchange resin
VL  - 61
IS  - 1
SP  - 13
EP  - 17
DO  - 10.2298/HEMIND0701013S
ER  - 
@article{
author = "Savić, Jasmina and Vasić, Vesna M. and Adnađević, Borivoj",
year = "2007",
abstract = "The adsorption kinetics of pyrazol- (PACA) and imidazol-azo-chromo-tropic acid (IACA) onto Dowex 1-X8 resin, as a function of the dye concentration and temperature were investigated at pH 4.5. The pseudo-first- and second-order kinetic models and intraparticle diffusion model were used to describe the obtained kinetic data. The adsorption rate constants were found to be in the order of magnitude 10(-2) min(-1) for all of the used kinetics models. The adsorption capacity increases with increasing initial dye concentration. The study of adsorption kinetics at different temperatures (in the range from 5 to 25 degrees C) reveals an increase in the rate of adsorption and adsorption capacity with increasing temperature. The activation energy (in the case of PACA 16.6 kJ/mol, and for IACA 11.3 kJ/mol) was determined using the Arrhenius dependence. Electrostatic interactions between the dye and resin beads were shown to be the adsorption mechanism.",
journal = "Hemijska industrija",
title = "Kinetic investigation of the immobilization of chromotropic acid derivatives onto anion exchange resin",
volume = "61",
number = "1",
pages = "13-17",
doi = "10.2298/HEMIND0701013S"
}
Savić, J., Vasić, V. M.,& Adnađević, B.. (2007). Kinetic investigation of the immobilization of chromotropic acid derivatives onto anion exchange resin. in Hemijska industrija, 61(1), 13-17.
https://doi.org/10.2298/HEMIND0701013S
Savić J, Vasić VM, Adnađević B. Kinetic investigation of the immobilization of chromotropic acid derivatives onto anion exchange resin. in Hemijska industrija. 2007;61(1):13-17.
doi:10.2298/HEMIND0701013S .
Savić, Jasmina, Vasić, Vesna M., Adnađević, Borivoj, "Kinetic investigation of the immobilization of chromotropic acid derivatives onto anion exchange resin" in Hemijska industrija, 61, no. 1 (2007):13-17,
https://doi.org/10.2298/HEMIND0701013S . .
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