TY  - JOUR
AU  - Trpković, Andreja
AU  - Putniković, Biljana
AU  - Sudar, Emina
AU  - Velebit, Jelena
AU  - Gluvić, Zoran
AU  - Ilić, Želmira
AU  - Đurić, Jovanka
AU  - Isenović, Esma R.
PY  - 2007
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10333
AB  - The effects of estradiol involve the activation of multiple signaling cascades, including and p42/44 mitogen-activated protein kinase. In addition, some of the effects of estradiol have been linked to activity of cytosolic phospholipase. The mechanisms of estradiol action on the cardiovascular system can be divided into two broad categories: effects on systemic cardiovascular risk factors, and direct effects on vascular cells. A number of direct vascular effects of estradiol have been reported, including its impact on the regulation of sodium pump activity and vasomotor tone. The sodium pump is a ubiquitous plasma membrane- bound enzyme that plays an essential role in regulatory vasomotion. The association between reduced sodium pump expression and the development and/or pathogenesis of several disease states including hypertension, congestive heart failure, chronic renal failure and diabetes underscores the importance of the sodium pump. We hypothesize that estradiol stimulates the vascular smooth muscle cell sodium pump via a mechanism involving phosphatydil inositol-3 kinase-dependent activation of cytosolic phospholipase and release of arachidonic acid , which activates the p42/44 mitogen-activated protein kinase cascade and further increases cytosolic phospholipase activity. Furthermore, we postulate that in a disease state such as hypertension (as in spontaneously hypertensive rat ), the resulting overproduction of Angiotensin II will interfere with estradiol regulation of the sodium pump.
AB  - Estradiol aktivira multipne kaskadne signalne reakcije u kojima su ukljuceni i enzimi, kinaze, kao sto su fosfatidil inozitol-3 kinaza i p42/44 mitogenom aktivirana kinaza. Takođe, se smatra da su pojedini efekti estradiola posledica aktivnosti citosolne fosfolipaze 2. Uticaj estradiola na kardiovaskularni sistem je dvojak: pored direktnog efekta na vaskularne ćelije, estradiol utiče i na sistemske faktore rizika koji dovode do pojave kardiovaskularne bolesti. Poznati su brojni direktni uticaji estradiola na vaskularni sistem, uključujući i ulogu estradiola u regulaciji aktivnosti natrijumove pumpe i vazomotornog tonusa. Natrijumova pumpa je ubikvitaran enzim lokalizovan u ćelijskoj membrani i ima značajnu ulogu u regulaciji vazomotornog tonusa. Poremecaj u regulaciji aktivnosti (npr. smanjena aktivnost), natrijumove pumpe je posebno izražena u nastanku i/ili patogenezi pojedinih oboljenja kao što su: hipertenzija, kongestivna srčana slabost, hronična bubrežna slabost i šećerna bolest. U nasem radu polazimo od hipoteze da estradiol stimuliše aktivnost/sintezu natrijumove pumpe u vaskularnim glatkim mišićnim ćelijama putem fosfatidil inozitol-3 kinazne-zavisne aktivacije citosolne fosfolipaze 2, nakon cega oslobođena arahidonska kiselina, indukuje aktivaciju p42/44 mitogenom aktiviriranu kinaznu kaskadnu reakciju sto dodatno doprinosi aktivnosti citosolne fosfolipaze 2.Takođe, smatramo da se u oboljenjima kao što je hipertenzija, povećana sinteza angiotenzina II ometa estradiolom regulisanu aktivnost/sintezu natrujumove pumpe.
T2  - Materia medica
T1  - Regulation of sodium pump by estradiol in vascular smooth muscle cells
T1  - Uloga estradiola u regulaciji netrijumove pumpe u vaskularnim glatkim mišićnim ćelijama
VL  - 23
IS  - 3
SP  - 32
EP  - 36
UR  - https://hdl.handle.net/21.15107/rcub_vinar_10333
ER  - 

@article{
author = "Trpković, Andreja and Putniković, Biljana and Sudar, Emina and Velebit, Jelena and Gluvić, Zoran and Ilić, Želmira and Đurić, Jovanka and Isenović, Esma R.",
year = "2007",
abstract = "The effects of estradiol involve the activation of multiple signaling cascades, including and p42/44 mitogen-activated protein kinase. In addition, some of the effects of estradiol have been linked to activity of cytosolic phospholipase. The mechanisms of estradiol action on the cardiovascular system can be divided into two broad categories: effects on systemic cardiovascular risk factors, and direct effects on vascular cells. A number of direct vascular effects of estradiol have been reported, including its impact on the regulation of sodium pump activity and vasomotor tone. The sodium pump is a ubiquitous plasma membrane- bound enzyme that plays an essential role in regulatory vasomotion. The association between reduced sodium pump expression and the development and/or pathogenesis of several disease states including hypertension, congestive heart failure, chronic renal failure and diabetes underscores the importance of the sodium pump. We hypothesize that estradiol stimulates the vascular smooth muscle cell sodium pump via a mechanism involving phosphatydil inositol-3 kinase-dependent activation of cytosolic phospholipase and release of arachidonic acid , which activates the p42/44 mitogen-activated protein kinase cascade and further increases cytosolic phospholipase activity. Furthermore, we postulate that in a disease state such as hypertension (as in spontaneously hypertensive rat ), the resulting overproduction of Angiotensin II will interfere with estradiol regulation of the sodium pump., Estradiol aktivira multipne kaskadne signalne reakcije u kojima su ukljuceni i enzimi, kinaze, kao sto su fosfatidil inozitol-3 kinaza i p42/44 mitogenom aktivirana kinaza. Takođe, se smatra da su pojedini efekti estradiola posledica aktivnosti citosolne fosfolipaze 2. Uticaj estradiola na kardiovaskularni sistem je dvojak: pored direktnog efekta na vaskularne ćelije, estradiol utiče i na sistemske faktore rizika koji dovode do pojave kardiovaskularne bolesti. Poznati su brojni direktni uticaji estradiola na vaskularni sistem, uključujući i ulogu estradiola u regulaciji aktivnosti natrijumove pumpe i vazomotornog tonusa. Natrijumova pumpa je ubikvitaran enzim lokalizovan u ćelijskoj membrani i ima značajnu ulogu u regulaciji vazomotornog tonusa. Poremecaj u regulaciji aktivnosti (npr. smanjena aktivnost), natrijumove pumpe je posebno izražena u nastanku i/ili patogenezi pojedinih oboljenja kao što su: hipertenzija, kongestivna srčana slabost, hronična bubrežna slabost i šećerna bolest. U nasem radu polazimo od hipoteze da estradiol stimuliše aktivnost/sintezu natrijumove pumpe u vaskularnim glatkim mišićnim ćelijama putem fosfatidil inozitol-3 kinazne-zavisne aktivacije citosolne fosfolipaze 2, nakon cega oslobođena arahidonska kiselina, indukuje aktivaciju p42/44 mitogenom aktiviriranu kinaznu kaskadnu reakciju sto dodatno doprinosi aktivnosti citosolne fosfolipaze 2.Takođe, smatramo da se u oboljenjima kao što je hipertenzija, povećana sinteza angiotenzina II ometa estradiolom regulisanu aktivnost/sintezu natrujumove pumpe.",
journal = "Materia medica",
title = "Regulation of sodium pump by estradiol in vascular smooth muscle cells, Uloga estradiola u regulaciji netrijumove pumpe u vaskularnim glatkim mišićnim ćelijama",
volume = "23",
number = "3",
pages = "32-36",
url = "https://hdl.handle.net/21.15107/rcub_vinar_10333"
}

Trpković, A., Putniković, B., Sudar, E., Velebit, J., Gluvić, Z., Ilić, Ž., Đurić, J.,& Isenović, E. R.. (2007). Regulation of sodium pump by estradiol in vascular smooth muscle cells. in Materia medica, 23(3), 32-36.
https://hdl.handle.net/21.15107/rcub_vinar_10333

Trpković A, Putniković B, Sudar E, Velebit J, Gluvić Z, Ilić Ž, Đurić J, Isenović ER. Regulation of sodium pump by estradiol in vascular smooth muscle cells. in Materia medica. 2007;23(3):32-36.
https://hdl.handle.net/21.15107/rcub_vinar_10333 .

Trpković, Andreja, Putniković, Biljana, Sudar, Emina, Velebit, Jelena, Gluvić, Zoran, Ilić, Želmira, Đurić, Jovanka, Isenović, Esma R., "Regulation of sodium pump by estradiol in vascular smooth muscle cells" in Materia medica, 23, no. 3 (2007):32-36,
https://hdl.handle.net/21.15107/rcub_vinar_10333 .