TY  - JOUR
AU  - Smit, Biljana
AU  - Pavlović, Radoslav Z.
AU  - Radosavljević-Mihajlović, Ana S.
AU  - Došen, Anja M.
AU  - Curcic, Milena G.
AU  - Seklic, Dragana S.
AU  - Živanović, Marko N.
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4370
AB  - The polydentate ligand 3-[(2-hydroxybenzylidene)amino]-2-thioxoimidazolidin-4-one was synthesized in the intermolecular cyclocondensation reaction of 2-hydroxybenzaldehyde thiosemicarbazone and ethyl chloroacetate. A novel palladium(II) complex was obtained from cis-[Pd(DMSO)(2)Cl-2] by nucleophilic substitution of both DMSO ligands with the iminic nitrogen and the thiolactamic sulfur from the ligand. The structures of the compounds were characterized based on their spectral data. The cytotoxic activities of the ligand and the palladium(II) complex were studied on the tumor cell lines: human colon carcinoma HCT-116 and SW-480 cells using the MTT viability test. The results showed that the investigated palladium(II) complex had a significantly greater cytotoxic effect compared to that of the ligand.
T2  - Journal of the Serbian Chemical Society
T1  - Synthesis, characterization and cytotoxicity of a palladium(II) complex of 3-[(2-hydroxybenzylidene)amino]-2-thioxoimidazolidin-4-one
VL  - 78
IS  - 2
SP  - 217
EP  - 227
DO  - 10.2298/JSC120725154S
ER  - 

@article{
author = "Smit, Biljana and Pavlović, Radoslav Z. and Radosavljević-Mihajlović, Ana S. and Došen, Anja M. and Curcic, Milena G. and Seklic, Dragana S. and Živanović, Marko N.",
year = "2013",
abstract = "The polydentate ligand 3-[(2-hydroxybenzylidene)amino]-2-thioxoimidazolidin-4-one was synthesized in the intermolecular cyclocondensation reaction of 2-hydroxybenzaldehyde thiosemicarbazone and ethyl chloroacetate. A novel palladium(II) complex was obtained from cis-[Pd(DMSO)(2)Cl-2] by nucleophilic substitution of both DMSO ligands with the iminic nitrogen and the thiolactamic sulfur from the ligand. The structures of the compounds were characterized based on their spectral data. The cytotoxic activities of the ligand and the palladium(II) complex were studied on the tumor cell lines: human colon carcinoma HCT-116 and SW-480 cells using the MTT viability test. The results showed that the investigated palladium(II) complex had a significantly greater cytotoxic effect compared to that of the ligand.",
journal = "Journal of the Serbian Chemical Society",
title = "Synthesis, characterization and cytotoxicity of a palladium(II) complex of 3-[(2-hydroxybenzylidene)amino]-2-thioxoimidazolidin-4-one",
volume = "78",
number = "2",
pages = "217-227",
doi = "10.2298/JSC120725154S"
}

Smit, B., Pavlović, R. Z., Radosavljević-Mihajlović, A. S., Došen, A. M., Curcic, M. G., Seklic, D. S.,& Živanović, M. N.. (2013). Synthesis, characterization and cytotoxicity of a palladium(II) complex of 3-[(2-hydroxybenzylidene)amino]-2-thioxoimidazolidin-4-one. in Journal of the Serbian Chemical Society, 78(2), 217-227.
https://doi.org/10.2298/JSC120725154S

Smit B, Pavlović RZ, Radosavljević-Mihajlović AS, Došen AM, Curcic MG, Seklic DS, Živanović MN. Synthesis, characterization and cytotoxicity of a palladium(II) complex of 3-[(2-hydroxybenzylidene)amino]-2-thioxoimidazolidin-4-one. in Journal of the Serbian Chemical Society. 2013;78(2):217-227.
doi:10.2298/JSC120725154S .

Smit, Biljana, Pavlović, Radoslav Z., Radosavljević-Mihajlović, Ana S., Došen, Anja M., Curcic, Milena G., Seklic, Dragana S., Živanović, Marko N., "Synthesis, characterization and cytotoxicity of a palladium(II) complex of 3-[(2-hydroxybenzylidene)amino]-2-thioxoimidazolidin-4-one" in Journal of the Serbian Chemical Society, 78, no. 2 (2013):217-227,
https://doi.org/10.2298/JSC120725154S . .